Protein Description Gene ednrb_1 ednrb_2 ednrb_3 WT1 WT2 WT3 ednrb.vs.WT FC ednrb.vs.WT Pvalue ednrb.vs.WT log2FC ednrb.vs.WT Sig ednrb.vs.WT UP.DOWN GO_NUM GO_Description KEGG_Description KEGG_EC KEGG_ko KOGs_Function_Description KOGs_Function_Class KOGs_Class_Description IPR_Term Subcellular_localization TF_family A0A338P6K2 Myosin-11 Myh11 433.6 445.7 689.6 589.6 503.4 546.1 0.957171618571167 0.801311558356579 -0.0631504752295806 Nonsignificant None 3 Molecular Function:motor activity (GO:0003774),Molecular Function:ATP binding (GO:0005524),Cellular Component:myosin complex (GO:0016459) myosin heavy chain -- ko04530 Tight junction Myosin class II heavy chain Z Cytoskeleton ; IPR001609 [Myosin head, motor domain] ; IPR002928[Myosin tail] ; IPR004009[Myosin, N-terminal, SH3-like] -- -- A0A2R8VHF9 Myosin-11 Myh11 269 294.7 312.1 430.5 349.6 392.8 0.746696223036917 0.0202046840099391 -0.421406661315706 Nonsignificant None 3 Molecular Function:motor activity (GO:0003774),Molecular Function:ATP binding (GO:0005524),Cellular Component:myosin complex (GO:0016459) myosin heavy chain -- ko04530 Tight junction Myosin class II heavy chain Z Cytoskeleton ; IPR001609 [Myosin head, motor domain] ; IPR002928[Myosin tail] ; IPR004009[Myosin, N-terminal, SH3-like] -- -- O08638 Myosin-11 Myh11 139.5 126.2 99.5 151.2 141.1 124.4 0.876409887209023 0.290926157835986 -0.190322334718327 Nonsignificant None 3 Molecular Function:motor activity (GO:0003774),Molecular Function:ATP binding (GO:0005524),Cellular Component:myosin complex (GO:0016459) myosin heavy chain -- ko04530 Tight junction Myosin class II heavy chain Z Cytoskeleton ; IPR001609 [Myosin head, motor domain] ; IPR002928[Myosin tail] ; IPR004009[Myosin, N-terminal, SH3-like] -- -- B7FAU9 Filamin, alpha Flna 90175.7 96829.5 99127 110053.8 103499.4 103733.6 0.901809340949576 0.0391069228886419 -0.149105641385828 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) filamin -- ko04010 MAPK signaling pathway ko04510 Focal adhesion ko05132 Salmonella infection ko05205 Proteoglycans in cancer Actin-binding cytoskeleton protein, filamin Z Cytoskeleton ; IPR001715 [Calponin homology domain] ; IPR017868[Filamin/ABP280 repeat-like] -- -- Q9QXS1 Plectin Plec 643 576.6 387.4 433.1 453.4 449.7 1.2026642718156 0.359605673379592 0.26623396505351 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:cytoskeleton (GO:0005856) plectin -- -- Dystonin, GAS (Growth-arrest-specific protein), and related proteins Z Cytoskeleton ; IPR001101 [Plectin repeat] ; IPR001715[Calponin homology domain] ; IPR005326[Plectin/S10, N-terminal] -- -- E9Q616 AHNAK nucleoprotein (desmoyokin) Ahnak 145536.6 140717.4 111137.1 105874.3 110472.5 106698.8 1.23013933636614 0.145461105535434 0.29882173710872 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q8VDD5 Myosin-9 Myh9 70648.6 73184.7 69554.2 66452.3 68093.4 65004 1.06934513056146 0.0299046600126342 0.0967275572580519 Nonsignificant None 3 Molecular Function:motor activity (GO:0003774),Molecular Function:ATP binding (GO:0005524),Cellular Component:myosin complex (GO:0016459) myosin heavy chain -- ko04530 Tight junction Myosin class II heavy chain Z Cytoskeleton ; IPR001609 [Myosin head, motor domain] ; IPR002928[Myosin tail] ; IPR004009[Myosin, N-terminal, SH3-like] -- -- P26039 Talin-1 Tln1 46094.8 48254.6 45792.9 48063.4 46676.7 47515.8 0.985142268264445 0.465271390400724 -0.0215960100153864 Nonsignificant None 5 Cellular Component:ruffle (GO:0001726),Molecular Function:actin binding (GO:0003779),Molecular Function:structural constituent of cytoskeleton (GO:0005200),Cellular Component:focal adhesion (GO:0005925),Biological Process:cytoskeletal anchoring at plasma membrane (GO:0007016) talin -- ko04015 Rap1 signaling pathway ko04510 Focal adhesion ko04611 Platelet activation ko05166 HTLV-I infection Talin Z Cytoskeleton ; IPR002558 [I/LWEQ domain] ; IPR015009[Vinculin-binding site-containing domain] ; IPR015224[Talin, central] ; IPR018979[FERM, N-terminal] ; IPR019748[FERM central domain] ; IPR032425[Talin, N-terminal F0 domain] -- -- Q9JHU4 Cytoplasmic dynein 1 heavy chain 1 Dync1h1 51669.7 51207.7 55560.2 54962.8 54963.7 56111.6 0.954224361757934 0.15166446995832 -0.0675995754707187 Nonsignificant None 5 Molecular Function:microtubule motor activity (GO:0003777),Molecular Function:ATP binding (GO:0005524),Biological Process:microtubule-based movement (GO:0007018),Molecular Function:ATPase activity (GO:0016887),Cellular Component:dynein complex (GO:0030286) dynein heavy chain 1, cytosolic -- ko04145 Phagosome ko04962 Vasopressin-regulated water reabsorption ko05132 Salmonella infection Dyneins, heavy chain Z Cytoskeleton ; IPR004273 [Dynein heavy chain domain] ; IPR011704[ATPase, dynein-related, AAA domain] ; IPR013594[Dynein heavy chain, domain-1] ; IPR013602[Dynein heavy chain, domain-2] ; IPR024317[Dynein heavy chain, P-loop containing D4 domain] ; IPR024743[Dynein heavy chain, coiled coil stalk] -- -- E9PWQ3 Collagen, type VI, alpha 3 Col6a3 1277.1 1305.2 1267.4 1413.3 1498.3 1451.3 0.88237181691077 0.00320800445624132 -0.180541383119897 Nonsignificant None 1 Molecular Function:serine-type endopeptidase inhibitor activity (GO:0004867) collagen, type VI, alpha -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04974 Protein digestion and absorption ko05165 Human papillomavirus infection Collagens (type IV and type XIII), and related proteins W Extracellular structures ; IPR002035 [von Willebrand factor, type A] ; IPR002223[Pancreatic trypsin inhibitor Kunitz domain] ; IPR008160[Collagen triple helix repeat] -- -- P16546 Spectrin alpha chain, non-erythrocytic 1 Sptan1 1363.6 1333.2 1442.5 1521.8 1414.4 1524.9 0.927865324695703 0.092809475090919 -0.108012674764569 Nonsignificant None 2 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:protein binding (GO:0005515) spectrin alpha -- ko04210 Apoptosis Ca2+-binding actin-bundling protein (spectrin), alpha chain (EF-Hand protein superfamily) Z Cytoskeleton ; IPR001452 [SH3 domain] ; IPR002017[Spectrin repeat] ; IPR002048[EF-hand domain] ; IPR014837[EF-hand, Ca insensitive] -- -- A0A087WS16 Collagen, type VI, alpha 3 Col6a3 201.3 174.4 185.5 306.7 267.7 272.7 0.662495573131862 0.00279255706808195 -0.594017280538575 Significant down 1 Molecular Function:serine-type endopeptidase inhibitor activity (GO:0004867) collagen, type VI, alpha -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04974 Protein digestion and absorption ko05165 Human papillomavirus infection Collagens (type IV and type XIII), and related proteins W Extracellular structures ; IPR002035 [von Willebrand factor, type A] ; IPR002223[Pancreatic trypsin inhibitor Kunitz domain] ; IPR008160[Collagen triple helix repeat] -- -- A3KGU5 Spectrin alpha chain, non-erythrocytic 1 Sptan1 192.8 190.8 226.9 211.7 227.4 189.9 0.970588235294118 0.719260906239825 -0.043068721891886 Nonsignificant None 2 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:protein binding (GO:0005515) spectrin alpha -- ko04210 Apoptosis Ca2+-binding actin-bundling protein (spectrin), alpha chain (EF-Hand protein superfamily) Z Cytoskeleton ; IPR001452 [SH3 domain] ; IPR002017[Spectrin repeat] ; IPR002048[EF-hand domain] ; IPR014837[EF-hand, Ca insensitive] -- -- Q80X90 Filamin-B Flnb 46143.8 44731.7 43475.7 42314.6 42554.5 42169.5 1.05756203232718 0.0841375516120453 0.0807422885046375 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) filamin -- ko04010 MAPK signaling pathway ko04510 Focal adhesion ko05132 Salmonella infection ko05205 Proteoglycans in cancer Actin-binding cytoskeleton protein, filamin Z Cytoskeleton ; IPR001715 [Calponin homology domain] ; IPR017868[Filamin/ABP280 repeat-like] -- -- P11679 Keratin, type II cytoskeletal 8 Krt8 79178.9 70420.2 72955.1 86613.7 85369.2 87727.5 0.856932182923749 0.00999590748514703 -0.222747060013958 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) type II keratin, basic -- -- -- -- -- IPR001664 [Intermediate filament protein] ; IPR032444[Keratin type II head] -- -- Q68FD5 Clathrin heavy chain 1 Cltc 36830 37414.7 38330.1 36451.1 37292.6 39244.3 0.996342974475166 0.890061391866337 -0.00528564335699228 Nonsignificant None 5 Molecular Function:structural molecule activity (GO:0005198),Biological Process:intracellular protein transport (GO:0006886),Biological Process:vesicle-mediated transport (GO:0016192),Cellular Component:clathrin coat of trans-Golgi network vesicle (GO:0030130),Cellular Component:clathrin coat of coated pit (GO:0030132) clathrin heavy chain -- ko04142 Lysosome ko04144 Endocytosis ko04721 Synaptic vesicle cycle ko04961 Endocrine and other factor-regulated calcium reabsorption ko05016 Huntington's disease ko05100 Bacterial invasion of epithelial cells Vesicle coat protein clathrin, heavy chain U Intracellular trafficking, secretion, and vesicular transport ; IPR000547 [Clathrin, heavy chain/VPS, 7-fold repeat] ; IPR015348[Clathrin, heavy chain, linker, core motif] ; IPR022365[Clathrin, heavy chain, propeller repeat] -- -- Q62261 Spectrin beta chain, non-erythrocytic 1 Sptbn1 28950.8 27688.2 28431.8 30687.9 30582 31161.7 0.920364896853457 0.00383100028144767 -0.119722135337964 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) spectrin beta -- -- Beta-spectrin Z Cytoskeleton ; IPR001715 [Calponin homology domain] ; IPR002017[Spectrin repeat] -- -- E9PZ16 Basement membrane-specific heparan sulfate proteoglycan core protein Hspg2 28013.1 28724.3 28370.8 31319.2 30637.6 30725 0.918283848608896 0.00104577988217032 -0.122987924164385 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) heparan sulfate proteoglycan 2 (perlecan) -- ko04512 ECM-receptor interaction ko05161 Hepatitis B ko05205 Proteoglycans in cancer Basement membrane-specific heparan sulfate proteoglycan (HSPG) core protein O Posttranslational modification, protein turnover, chaperones ; IPR000034 [Laminin IV] ; IPR000742[EGF-like domain] ; IPR001791[Laminin G domain] ; IPR002049[Laminin EGF domain] ; IPR002172[Low-density lipoprotein (LDL) receptor class A repeat] ; IPR013098[Immunoglobulin I-set] -- -- Q8VHX6 Filamin-C Flnc 32397.2 34513.6 31856.3 32894.7 30698.3 29857.4 1.05689328242576 0.218546680137944 0.0798297109799968 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) filamin -- ko04010 MAPK signaling pathway ko04510 Focal adhesion ko05132 Salmonella infection ko05205 Proteoglycans in cancer Actin-binding cytoskeleton protein, filamin Z Cytoskeleton ; IPR001715 [Calponin homology domain] ; IPR017868[Filamin/ABP280 repeat-like] -- -- Q6URW6 Myosin-14 Myh14 28599.4 25192.1 27966.9 32467.5 31959.3 31796.8 0.849670974688122 0.0106227793281964 -0.235023812556686 Nonsignificant None 3 Molecular Function:motor activity (GO:0003774),Molecular Function:ATP binding (GO:0005524),Cellular Component:myosin complex (GO:0016459) myosin heavy chain -- ko04530 Tight junction Myosin class II heavy chain Z Cytoskeleton ; IPR001609 [Myosin head, motor domain] ; IPR002928[Myosin tail] ; IPR004009[Myosin, N-terminal, SH3-like] -- -- Q3UHL6 Fibronectin Fn1 1149.6 1258.1 1109.5 852.8 872.9 761.3 1.41423401688782 0.00361273865831721 0.500020866306429 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:extracellular region (GO:0005576) fibronectin 1 -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04810 Regulation of actin cytoskeleton ko04933 AGE-RAGE signaling pathway in diabetic complications ko05100 Bacterial invasion of epithelial cells ko05146 Amoebiasis ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05222 Small cell lung cancer -- -- -- IPR000083 [Fibronectin, type I] ; IPR000562[Fibronectin, type II, collagen-binding] ; IPR003961[Fibronectin type III] -- -- Q546G4 Serum albumin Alb 122156.4 122453.6 96772.1 70528.1 75883.1 73606.2 1.55161409961212 0.00947613458159158 0.633769790899507 Significant up 1 Cellular Component:extracellular space (GO:0005615) serum albumin -- ko04918 Thyroid hormone synthesis -- -- -- IPR014760 [Serum albumin, N-terminal] -- -- B9EHT6 Fibronectin Fn1 166.7 193.4 222.8 176.5 162.7 180.7 1.12117714945182 0.286472160729405 0.165014246425175 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:extracellular region (GO:0005576) fibronectin 1 -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04810 Regulation of actin cytoskeleton ko04933 AGE-RAGE signaling pathway in diabetic complications ko05100 Bacterial invasion of epithelial cells ko05146 Amoebiasis ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05222 Small cell lung cancer -- -- -- IPR000083 [Fibronectin, type I] ; IPR000562[Fibronectin, type II, collagen-binding] ; IPR003961[Fibronectin type III] -- -- Q64727 Vinculin Vcl 38108.4 40870.2 40400.9 45484.3 43196.5 43754.9 0.901414799785858 0.0165497341200043 -0.149736957900006 Nonsignificant None 2 Biological Process:cell adhesion (GO:0007155),Molecular Function:actin filament binding (GO:0051015) vinculin -- ko04510 Focal adhesion ko04520 Adherens junction ko04670 Leukocyte transendothelial migration ko04810 Regulation of actin cytoskeleton ko05100 Bacterial invasion of epithelial cells ko05146 Amoebiasis Alpha-catenin W Extracellular structures ; IPR006077 [Vinculin/alpha-catenin] -- -- Q9JKF1 Ras GTPase-activating-like protein IQGAP1 Iqgap1 24008.1 23459.4 24180.8 27835.8 27764 28530 0.851639965862275 0.000219921629588725 -0.231684440542924 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Biological Process:regulation of GTPase activity (GO:0043087) Ras GTPase-activating-like protein IQGAP1 -- ko04520 Adherens junction ko04810 Regulation of actin cytoskeleton ko05205 Proteoglycans in cancer Ras GTPase-activating protein family - IQGAP T Signal transduction mechanisms ; IPR000048 [IQ motif, EF-hand binding site] ; IPR000593[RasGAP protein, C-terminal] ; IPR001715[Calponin homology domain] ; IPR001936[Ras GTPase-activating protein] -- -- E9Q557 Desmoplakin Dsp 31476.8 28618.4 31085.4 32164 32987.8 32121.8 0.937362244226594 0.0963430415962397 -0.0933214088436661 Nonsignificant None 1 Cellular Component:cytoskeleton (GO:0005856) desmoplakin -- ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) Dystonin, GAS (Growth-arrest-specific protein), and related proteins Z Cytoskeleton ; IPR001101 [Plectin repeat] -- -- Q3TH56 Uncharacterized protein Hspa8 42584.1 43473.2 38750.7 36046.1 35803.8 36406.2 1.1528957721551 0.0605955234653735 0.205262091661128 Nonsignificant None -- -- heat shock 70kDa protein 1/2/6/8 -- ko03040 Spliceosome ko04010 MAPK signaling pathway ko04141 Protein processing in endoplasmic reticulum ko04144 Endocytosis ko04213 Longevity regulating pathway - multiple species ko04612 Antigen processing and presentation ko04915 Estrogen signaling pathway ko05134 Legionellosis ko05145 Toxoplasmosis ko05162 Measles ko05164 Influenza A ko05169 Epstein-Barr virus infection Molecular chaperones HSP70/HSC70, HSP70 superfamily O Posttranslational modification, protein turnover, chaperones ; IPR013126 [Heat shock protein 70 family] -- -- P19001 Keratin, type I cytoskeletal 19 Krt19 56678.9 49924.8 56016.3 69021.4 67840.4 70944.5 0.782555678052109 0.00295905482740624 -0.353734692884249 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) type I keratin, acidic -- -- -- -- -- IPR001664 [Intermediate filament protein] -- -- Q71LX8 Heat shock protein 84b Hsp90ab1 25935.5 26070.5 22383.4 20381 20705.5 20361.7 1.21060340254068 0.0689713403441504 0.275726311027477 Nonsignificant None 4 Molecular Function:ATP binding (GO:0005524),Biological Process:protein folding (GO:0006457),Biological Process:response to stress (GO:0006950),Molecular Function:unfolded protein binding (GO:0051082) molecular chaperone HtpG -- ko04141 Protein processing in endoplasmic reticulum ko04151 PI3K-Akt signaling pathway ko04217 Necroptosis ko04612 Antigen processing and presentation ko04621 NOD-like receptor signaling pathway ko04657 IL-17 signaling pathway ko04659 Th17 cell differentiation ko04914 Progesterone-mediated oocyte maturation ko04915 Estrogen signaling pathway ko05200 Pathways in cancer ko05215 Prostate cancer ko05418 Fluid shear stress and atherosclerosis Molecular chaperone (HSP90 family) O Posttranslational modification, protein turnover, chaperones ; IPR001404 [Heat shock protein Hsp90 family] ; IPR003594[Histidine kinase-like ATPase, C-terminal domain] -- -- A1BN54 Alpha actinin 1a Actn1 22362.6 23593.5 23930.8 25111 24373.4 23680.3 0.955199706962511 0.158231520849186 -0.0661257008765599 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) actinin alpha 1/4 -- ko04510 Focal adhesion ko04520 Adherens junction ko04530 Tight junction ko04670 Leukocyte transendothelial migration ko04810 Regulation of actin cytoskeleton ko05146 Amoebiasis ko05203 Viral carcinogenesis ko05322 Systemic lupus erythematosus Ca2+-binding actin-bundling protein (actinin), alpha chain (EF-Hand protein superfamily) Z Cytoskeleton ; IPR001715 [Calponin homology domain] ; IPR002017[Spectrin repeat] ; IPR014837[EF-hand, Ca insensitive] -- -- P58252 Elongation factor 2 Eef2 53998.1 53969.7 48148.1 41759.1 43369.5 42944.5 1.21895932869588 0.00955883110650423 0.28564999038172 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) elongation factor 2 -- ko04152 AMPK signaling pathway ko04921 Oxytocin signaling pathway Elongation factor 2 J Translation, ribosomal structure and biogenesis ; IPR000640 [Translation elongation factor EFG, V domain] ; IPR004161[Translation elongation factor EFTu-like, domain 2] ; IPR005517[Translation elongation factor EFG/EF2, domain IV] ; IPR009022[Elongation factor G, III-V domain] -- -- Q3ULT2 Non-muscle alpha-actinin 4 Actn4 23869.6 23945 24824.6 24948.2 25405.3 24023.7 0.976632623976165 0.31860872247642 -0.0341121235242106 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) actinin alpha 1/4 -- ko04510 Focal adhesion ko04520 Adherens junction ko04530 Tight junction ko04670 Leukocyte transendothelial migration ko04810 Regulation of actin cytoskeleton ko05146 Amoebiasis ko05203 Viral carcinogenesis ko05322 Systemic lupus erythematosus Ca2+-binding actin-bundling protein (actinin), alpha chain (EF-Hand protein superfamily) Z Cytoskeleton ; IPR001715 [Calponin homology domain] ; IPR002017[Spectrin repeat] ; IPR014837[EF-hand, Ca insensitive] -- -- P63268 Actin, gamma-enteric smooth muscle Actg2 46.9 63.2 53.6 79.2 81.9 67.4 0.716411378555799 0.0292357118478281 -0.481139843471279 Nonsignificant None -- -- actin, gamma-enteric smooth muscle -- ko04270 Vascular smooth muscle contraction Actin and related proteins Z Cytoskeleton ; IPR004000 [Actin family] -- -- P19096 Fatty acid synthase Fasn 20251.6 19447.2 19691.9 21539.3 23828.2 22362 0.876880827409032 0.0173595857340133 -0.189547308532672 Nonsignificant None 2 Biological Process:biosynthetic process (GO:0009058),Biological Process:oxidation-reduction process (GO:0055114) fatty acid synthase, animal type 2.3.1.85 ko00061 Fatty acid biosynthesis ko01100 Metabolic pathways ko01212 Fatty acid metabolism ko04152 AMPK signaling pathway ko04910 Insulin signaling pathway Animal-type fatty acid synthase and related proteins I Lipid transport and metabolism ; IPR001031 [Thioesterase] ; IPR009081[Phosphopantetheine binding ACP domain] ; IPR013149[Alcohol dehydrogenase, C-terminal] ; IPR013217[Methyltransferase type 12] ; IPR013968[Polyketide synthase, ketoreductase domain] ; IPR014030[Beta-ketoacyl synthase, N-terminal] ; IPR014031[Beta-ketoacyl synthase, C-terminal] ; IPR014043[Acyl transferase] ; IPR020807[Polyketide synthase, dehydratase domain] ; IPR032821[Ketoacyl-synthetase, C-terminal extension] -- -- Q3UH59 Myosin-10 Myh10 9146.1 9318.3 10217.5 8855.3 9056.4 8959 1.06740427305578 0.14788572881025 0.0941066918782959 Nonsignificant None 4 Molecular Function:motor activity (GO:0003774),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Cellular Component:myosin complex (GO:0016459) myosin heavy chain -- ko04530 Tight junction Myosin class II heavy chain Z Cytoskeleton ; IPR000048 [IQ motif, EF-hand binding site] ; IPR001609[Myosin head, motor domain] ; IPR002928[Myosin tail] ; IPR004009[Myosin, N-terminal, SH3-like] -- -- Q3UBP6 Uncharacterized protein Actb 150.2 159.9 142.6 177.7 167.8 170.3 0.877665761923226 0.0225041229783809 -0.188256466541375 Nonsignificant None -- -- actin beta/gamma 1 -- ko04015 Rap1 signaling pathway ko04145 Phagosome ko04210 Apoptosis ko04390 Hippo signaling pathway ko04510 Focal adhesion ko04520 Adherens junction ko04530 Tight junction ko04611 Platelet activation ko04670 Leukocyte transendothelial migration ko04810 Regulation of actin cytoskeleton ko04919 Thyroid hormone signaling pathway ko04921 Oxytocin signaling pathway ko05100 Bacterial invasion of epithelial cells ko05132 Salmonella infection ko05164 Influenza A ko05205 Proteoglycans in cancer ko05225 Hepatocellular carcinoma ko05410 Hypertrophic cardiomyopathy (HCM) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05414 Dilated cardiomyopathy (DCM) ko05416 Viral myocarditis ko05418 Fluid shear stress and atherosclerosis Actin and related proteins Z Cytoskeleton ; IPR004000 [Actin family] -- -- P56480 ATP synthase subunit beta, mitochondrial Atp5f1b 27383.8 26081.1 26574.7 27064.7 26579.4 27524 0.986096754759567 0.466135622894479 -0.0201988856437173 Nonsignificant None 3 Molecular Function:ATP binding (GO:0005524),Biological Process:proton transport (GO:0015992),Biological Process:ATP metabolic process (GO:0046034) F-type H+-transporting ATPase subunit beta 3.6.3.14 ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease F0F1-type ATP synthase, beta subunit C Energy production and conversion ; IPR000194 [ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain] ; IPR004100[ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain] -- -- Q61554 Fibrillin-1 Fbn1 21093.6 21416.1 20367.5 22537.8 23886.5 22841.6 0.907765581620971 0.0142304421201108 -0.139608306067472 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) fibrillin 1 -- -- Fibrillins and related proteins containing Ca2+-binding EGF-like domains T Signal transduction mechanisms ; IPR001881 [EGF-like calcium-binding domain] ; IPR017878[TB domain] ; IPR026823[Complement Clr-like EGF domain] -- -- Q01853 Transitional endoplasmic reticulum ATPase Vcp 23786.5 23426.2 24492.1 22474.9 22641.7 22569.8 1.05936790847201 0.0475665515945196 0.0832037107183583 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) transitional endoplasmic reticulum ATPase -- ko04141 Protein processing in endoplasmic reticulum ko05134 Legionellosis AAA+-type ATPase O Posttranslational modification, protein turnover, chaperones ; IPR003338 [CDC48, N-terminal subdomain] ; IPR003959[ATPase, AAA-type, core] ; IPR004201[CDC48, domain 2] ; IPR015415[Vps4 oligomerisation, C-terminal] -- -- P01027 Complement C3 C3 31701.1 34602.7 28388.4 17971.7 19589.7 18324.6 1.6943814193179 0.00225178967971388 0.760758673854534 Significant up 3 Molecular Function:endopeptidase inhibitor activity (GO:0004866),Cellular Component:extracellular region (GO:0005576),Cellular Component:extracellular space (GO:0005615) complement component 3 -- ko04145 Phagosome ko04610 Complement and coagulation cascades ko05133 Pertussis ko05134 Legionellosis ko05140 Leishmaniasis ko05142 Chagas disease (American trypanosomiasis) ko05150 Staphylococcus aureus infection ko05152 Tuberculosis ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection ko05203 Viral carcinogenesis ko05322 Systemic lupus erythematosus Alpha-macroglobulin O Posttranslational modification, protein turnover, chaperones ; IPR000020 [Anaphylatoxin/fibulin] ; IPR001599[Alpha-2-macroglobulin] ; IPR002890[Alpha-2-macroglobulin, N-terminal] ; IPR009048[Alpha-macroglobulin, receptor-binding] ; IPR011625[Alpha-2-macroglobulin, N-terminal 2] ; IPR011626[Alpha-macroglobulin complement component] ; IPR018933[Netrin module, non-TIMP type] ; IPR019565[Alpha-2-macroglobulin, thiol-ester bond-forming] -- -- Q3V2C6 IF rod domain-containing protein Des 40149 43735.1 36153.5 39180.4 36211.2 33696.8 1.1003699751761 0.248278713010123 0.137988679758113 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) desmin -- ko05410 Hypertrophic cardiomyopathy (HCM) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05414 Dilated cardiomyopathy (DCM) -- -- -- IPR001664 [Intermediate filament protein] ; IPR006821[Intermediate filament head, DNA-binding domain] -- -- P10126 Elongation factor 1-alpha 1 Eef1a1 23593.5 23651.9 19446.5 17115.8 17311.5 17330.4 1.28854064226192 0.0697412712934819 0.365738042409032 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) elongation factor 1-alpha -- ko03013 RNA transport ko05134 Legionellosis Translation elongation factor EF-1 alpha/Tu J Translation, ribosomal structure and biogenesis ; IPR004160 [Translation elongation factor EFTu/EF1A, C-terminal] ; IPR004161[Translation elongation factor EFTu-like, domain 2] -- -- A0A087WSG8 Mucin-2 Muc2 33030.1 28637.6 42772.8 39381.1 38821.8 36600.3 0.90973509449214 0.463154484306554 -0.136481586389465 Nonsignificant None -- -- mucin-2 -- ko05146 Amoebiasis ko05226 Gastric cancer von Willebrand factor and related coagulation proteins WV Extracellular structures ; Defense mechanisms ; IPR001846 [von Willebrand factor, type D domain] ; IPR002919[Trypsin Inhibitor-like, cysteine rich domain] ; IPR014853[Uncharacterised domain, cysteine-rich] ; IPR025155[WxxW domain] -- -- P63038 60 kDa heat shock protein, mitochondrial Hspd1 32089.5 30772.1 30634.8 27839.3 28624.2 27752.5 1.11019758715683 0.00460552225509869 0.15081646274046 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) chaperonin GroEL -- ko03018 RNA degradation ko04940 Type I diabetes mellitus ko05134 Legionellosis ko05152 Tuberculosis Mitochondrial chaperonin, Cpn60/Hsp60p O Posttranslational modification, protein turnover, chaperones ; IPR002423 [Chaperonin Cpn60/TCP-1 family] -- -- Q8R0W0 Epiplakin Eppk1 13295.5 12586.7 13276.4 16371.1 16693.1 16892.3 0.783853952939057 0.000205976821232394 -0.351343217330294 Nonsignificant None 1 Cellular Component:cytoskeleton (GO:0005856) -- -- -- Dystonin, GAS (Growth-arrest-specific protein), and related proteins Z Cytoskeleton ; IPR001101 [Plectin repeat] -- -- E9Q9C6 Fc fragment of IgG-binding protein Fcgbp 14136.4 11882.9 15214.5 22067.3 21409.5 23369 0.61684952532545 0.00168859135195713 -0.697009494561329 Significant down -- -- -- -- -- von Willebrand factor and related coagulation proteins WV Extracellular structures ; Defense mechanisms ; IPR001846 [von Willebrand factor, type D domain] ; IPR002919[Trypsin Inhibitor-like, cysteine rich domain] ; IPR014853[Uncharacterised domain, cysteine-rich] ; IPR025615[TILa domain] -- -- Q921I1 Serotransferrin Tf 50458.8 54420.2 43520.2 24667.1 25624.2 26679.9 1.92798345355146 0.00182202442212103 0.947092670042101 Significant up -- -- transferrin -- ko04066 HIF-1 signaling pathway ko04216 Ferroptosis ko04978 Mineral absorption -- -- -- IPR001156 [Transferrin-like domain] -- -- P07901 Heat shock protein HSP 90-alpha Hsp90aa1 13781.2 14016.6 13361.3 12755.5 13264.8 12285.3 1.07449302451861 0.0496131658454706 0.103656116990846 Nonsignificant None 4 Molecular Function:ATP binding (GO:0005524),Biological Process:protein folding (GO:0006457),Biological Process:response to stress (GO:0006950),Molecular Function:unfolded protein binding (GO:0051082) molecular chaperone HtpG -- ko04141 Protein processing in endoplasmic reticulum ko04151 PI3K-Akt signaling pathway ko04217 Necroptosis ko04612 Antigen processing and presentation ko04621 NOD-like receptor signaling pathway ko04657 IL-17 signaling pathway ko04659 Th17 cell differentiation ko04914 Progesterone-mediated oocyte maturation ko04915 Estrogen signaling pathway ko05200 Pathways in cancer ko05215 Prostate cancer ko05418 Fluid shear stress and atherosclerosis Molecular chaperone (HSP90 family) O Posttranslational modification, protein turnover, chaperones ; IPR001404 [Heat shock protein Hsp90 family] ; IPR003594[Histidine kinase-like ATPase, C-terminal domain] -- -- P40142 Transketolase Tkt 28258.6 28471.8 27472.1 27179.9 26391 26890.3 1.04649818794649 0.030805624999378 0.0655698135115598 Nonsignificant None -- -- transketolase 2.2.1.1 ko00030 Pentose phosphate pathway ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids Transketolase G Carbohydrate transport and metabolism ; IPR005474 [Transketolase, N-terminal] ; IPR005475[Transketolase-like, pyrimidine-binding domain] ; IPR033248[Transketolase, C-terminal domain] -- -- P17182 Alpha-enolase Eno1 33457.3 32574.4 30476.2 28106.5 29127.5 28482.3 1.12589904137253 0.0182167693011791 0.171077467701201 Nonsignificant None -- -- enolase 4.2.1.11 ko00010 Glycolysis / Gluconeogenesis ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids ko03018 RNA degradation ko04066 HIF-1 signaling pathway Enolase G Carbohydrate transport and metabolism ; IPR020810 [Enolase, C-terminal TIM barrel domain] ; IPR020811[Enolase, N-terminal] -- -- Q3TIJ9 Uncharacterized protein Actb 79.1 79.5 82.7 91.6 105.8 115.7 0.770680293835835 0.0278491349275678 -0.375795592922918 Nonsignificant None -- -- actin beta/gamma 1 -- ko04015 Rap1 signaling pathway ko04145 Phagosome ko04210 Apoptosis ko04390 Hippo signaling pathway ko04510 Focal adhesion ko04520 Adherens junction ko04530 Tight junction ko04611 Platelet activation ko04670 Leukocyte transendothelial migration ko04810 Regulation of actin cytoskeleton ko04919 Thyroid hormone signaling pathway ko04921 Oxytocin signaling pathway ko05100 Bacterial invasion of epithelial cells ko05132 Salmonella infection ko05164 Influenza A ko05205 Proteoglycans in cancer ko05225 Hepatocellular carcinoma ko05410 Hypertrophic cardiomyopathy (HCM) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05414 Dilated cardiomyopathy (DCM) ko05416 Viral myocarditis ko05418 Fluid shear stress and atherosclerosis Actin and related proteins Z Cytoskeleton ; IPR004000 [Actin family] -- -- Q03265 ATP synthase subunit alpha, mitochondrial Atp5f1a 35584.7 33770.2 37026.4 39575.1 38529.3 39050.1 0.908042798185302 0.0221565491467066 -0.139167798170087 Nonsignificant None 4 Molecular Function:ATP binding (GO:0005524),Biological Process:ATP synthesis coupled proton transport (GO:0015986),Biological Process:proton transport (GO:0015992),Biological Process:ATP metabolic process (GO:0046034) F-type H+-transporting ATPase subunit alpha -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease F0F1-type ATP synthase, alpha subunit C Energy production and conversion ; IPR000194 [ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain] ; IPR000793[ATP synthase, alpha subunit, C-terminal] ; IPR004100[ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain] -- -- P20029 Endoplasmic reticulum chaperone BiP Hspa5 35044.7 34291.7 32997.9 29230.4 29578.3 27804.4 1.18151064908195 0.00290461962358096 0.240632632535193 Nonsignificant None -- -- heat shock 70kDa protein 5 -- ko03060 Protein export ko04141 Protein processing in endoplasmic reticulum ko04918 Thyroid hormone synthesis ko05020 Prion diseases Molecular chaperones GRP78/BiP/KAR2, HSP70 superfamily O Posttranslational modification, protein turnover, chaperones ; IPR013126 [Heat shock protein 70 family] -- -- P52480 Pyruvate kinase PKM Pkm 27404.2 27502.3 25254.8 24406.8 25987.3 24877.4 1.06496217027693 0.134373109424875 0.0908021837626632 Nonsignificant None 4 Molecular Function:magnesium ion binding (GO:0000287),Molecular Function:pyruvate kinase activity (GO:0004743),Biological Process:glycolytic process (GO:0006096),Molecular Function:potassium ion binding (GO:0030955) pyruvate kinase 2.7.1.40 ko00010 Glycolysis / Gluconeogenesis ko00230 Purine metabolism ko00620 Pyruvate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids ko04922 Glucagon signaling pathway ko04930 Type II diabetes mellitus ko05165 Human papillomavirus infection ko05203 Viral carcinogenesis ko05230 Central carbon metabolism in cancer Pyruvate kinase G Carbohydrate transport and metabolism ; IPR015793 [Pyruvate kinase, barrel] ; IPR015795[Pyruvate kinase, C-terminal] -- -- P68369 Tubulin alpha-1A chain Tuba1a 546 530.2 399.5 391.4 402.4 374.4 1.26322547508988 0.0953109068419092 0.337112171003034 Nonsignificant None 1 Molecular Function:GTPase activity (GO:0003924) tubulin alpha -- ko04145 Phagosome ko04210 Apoptosis ko04530 Tight junction ko04540 Gap junction Alpha tubulin Z Cytoskeleton ; IPR003008 [Tubulin/FtsZ, GTPase domain] ; IPR018316[Tubulin/FtsZ, 2-layer sandwich domain] -- -- Q8VDN2 Sodium/potassium-transporting ATPase subunit alpha-1 Atp1a1 15651.1 15407.1 17293 19937.3 19434.2 20084 0.813233426680459 0.00404864654033949 -0.29825857877626 Nonsignificant None 2 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:metal ion binding (GO:0046872) sodium/potassium-transporting ATPase subunit alpha 3.6.3.9 ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04260 Cardiac muscle contraction ko04261 Adrenergic signaling in cardiomyocytes ko04911 Insulin secretion ko04918 Thyroid hormone synthesis ko04919 Thyroid hormone signaling pathway ko04925 Aldosterone synthesis and secretion ko04960 Aldosterone-regulated sodium reabsorption ko04961 Endocrine and other factor-regulated calcium reabsorption ko04964 Proximal tubule bicarbonate reclamation ko04970 Salivary secretion ko04971 Gastric acid secretion ko04972 Pancreatic secretion ko04973 Carbohydrate digestion and absorption ko04974 Protein digestion and absorption ko04976 Bile secretion ko04978 Mineral absorption Na+/K+ ATPase, alpha subunit P Inorganic ion transport and metabolism ; IPR004014 [Cation-transporting P-type ATPase, N-terminal] ; IPR006068[Cation-transporting P-type ATPase, C-terminal] ; IPR008250[P-type ATPase, A domain] -- -- E9Q3X0 Major vault protein Mvp 391.6 371.8 323.1 341.3 366.9 349.7 1.02703469136969 0.683147145242002 0.0384849141018018 Nonsignificant None -- -- major vault protein -- -- -- -- -- IPR002499 [Major vault protein, N-terminal] ; IPR021870[Major vault protein, shoulder domain] -- -- Q3TFD9 Vimentin Vim 428.7 469.4 450 484.2 487.6 451.5 0.947165038993887 0.202222339501112 -0.0783122645549977 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) vimentin -- ko05169 Epstein-Barr virus infection ko05206 MicroRNAs in cancer -- -- -- IPR001664 [Intermediate filament protein] ; IPR006821[Intermediate filament head, DNA-binding domain] -- -- Q99JX6 Annexin Anxa6 2927.5 3075.7 3139.3 2996.3 2932.8 3075.8 1.01528056946773 0.574638960639546 0.0218784665683676 Nonsignificant None 2 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:calcium-dependent phospholipid binding (GO:0005544) annexin A6 -- -- Annexin U Intracellular trafficking, secretion, and vesicular transport ; IPR018502 [Annexin repeat] -- -- P48678 Prelamin-A/C Lmna 28522.4 26963.6 25698 34667.2 32744.8 34164.7 0.799238408020737 0.0024396376086465 -0.323302180263518 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) lamin A/C -- ko04210 Apoptosis ko05410 Hypertrophic cardiomyopathy (HCM) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05414 Dilated cardiomyopathy (DCM) Nuclear envelope protein lamin, intermediate filament superfamily DY Cell cycle control, cell division, chromosome partitioning ; Nuclear structure ; IPR001322 [Lamin Tail Domain] ; IPR001664[Intermediate filament protein] -- -- Q60847 Collagen alpha-1(XII) chain Col12a1 18682 19835.8 21617.9 22125.9 21296.7 20669 0.938277402967003 0.238462033758448 -0.0919135743663324 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) collagen, type XII, alpha -- ko04974 Protein digestion and absorption Collagens (type IV and type XIII), and related proteins W Extracellular structures ; IPR002035 [von Willebrand factor, type A] ; IPR003961[Fibronectin type III] ; IPR008160[Collagen triple helix repeat] -- -- A0A1S6GWH5 E1 ubiquitin-activating enzyme Uba1 20088.7 19872 20387.3 20333 20194.7 19646.6 1.00288661438521 0.833031988933025 0.00415850514153824 Nonsignificant None 1 Molecular Function:small protein activating enzyme activity (GO:0008641) ubiquitin-activating enzyme E1 6.2.1.45 ko04120 Ubiquitin mediated proteolysis ko05012 Parkinson's disease Ubiquitin activating enzyme UBA1 O Posttranslational modification, protein turnover, chaperones ; IPR000594 [THIF-type NAD/FAD binding fold] ; IPR018965[Ubiquitin-activating enzyme E1, C-terminal] ; IPR019572[Ubiquitin-activating enzyme, catalytic cysteine domain] ; IPR032418[Ubiquitin-activating enzyme E1, FCCH domain] ; IPR032420[Ubiquitin-activating enzyme E1, four-helix bundle] -- -- Q52L87 Tubulin alpha chain Tuba1c 479.2 999.5 999.6 774.6 684.7 601.7 1.20247452692868 0.483897118585748 0.266006332446107 Nonsignificant None 1 Molecular Function:GTPase activity (GO:0003924) tubulin alpha -- ko04145 Phagosome ko04210 Apoptosis ko04530 Tight junction ko04540 Gap junction Alpha tubulin Z Cytoskeleton ; IPR003008 [Tubulin/FtsZ, GTPase domain] ; IPR018316[Tubulin/FtsZ, 2-layer sandwich domain] -- -- Q3TWV0 Vimentin Vim 853.4 891.7 888.6 929.9 989.6 852.4 0.950142501533244 0.329963297510895 -0.0737841910882639 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) vimentin -- ko05169 Epstein-Barr virus infection ko05206 MicroRNAs in cancer -- -- -- IPR001664 [Intermediate filament protein] ; IPR006821[Intermediate filament head, DNA-binding domain] -- -- A0A0A0MQF6 Glyceraldehyde-3-phosphate dehydrogenase Gapdh 2264.2 2326.7 172 160.4 163.6 183.9 9.37763339240008 0.183060700804402 3.22922387968737 Nonsignificant None 1 Biological Process:oxidation-reduction process (GO:0055114) glyceraldehyde 3-phosphate dehydrogenase 1.2.1.12 ko00010 Glycolysis / Gluconeogenesis ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids ko04066 HIF-1 signaling pathway ko05010 Alzheimer's disease Glyceraldehyde 3-phosphate dehydrogenase G Carbohydrate transport and metabolism ; IPR020828 [Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain] ; IPR020829[Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain] -- -- Q99KI0 Aconitate hydratase, mitochondrial Aco2 17607.6 16929.6 20121.6 25460.5 24182 25368.7 0.72867518450578 0.00300357563054183 -0.45665223524781 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) aconitate hydratase 4.2.1.3 ko00020 Citrate cycle (TCA cycle) ko00630 Glyoxylate and dicarboxylate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01210 2-Oxocarboxylic acid metabolism ko01230 Biosynthesis of amino acids Aconitase/homoaconitase (aconitase superfamily) CE Energy production and conversion ; Amino acid transport and metabolism ; IPR000573 [Aconitase A/isopropylmalate dehydratase small subunit, swivel domain] ; IPR001030[Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain] -- -- B7ZNL3 Tpm1 protein Tpm1 9874.2 11167.8 10903.6 13265.9 12067.8 12357.4 0.847563483156501 0.0231404897634633 -0.238606663623612 Nonsignificant None -- -- tropomyosin 1 -- ko04260 Cardiac muscle contraction ko04261 Adrenergic signaling in cardiomyocytes ko05206 MicroRNAs in cancer ko05410 Hypertrophic cardiomyopathy (HCM) ko05414 Dilated cardiomyopathy (DCM) Actin filament-coating protein tropomyosin Z Cytoskeleton ; IPR000533 [Tropomyosin] -- -- Q6PDN3 Myosin light chain kinase, smooth muscle Mylk 17093.5 18713.5 19569.3 21621.5 19619.5 20181.9 0.901557888018964 0.0984614513374093 -0.149507966428155 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) myosin-light-chain kinase 2.7.11.18 ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04270 Vascular smooth muscle contraction ko04371 Apelin signaling pathway ko04510 Focal adhesion ko04611 Platelet activation ko04810 Regulation of actin cytoskeleton ko04921 Oxytocin signaling pathway ko04971 Gastric acid secretion Projectin/twitchin and related proteins Z Cytoskeleton ; IPR000719 [Protein kinase domain] ; IPR003961[Fibronectin type III] ; IPR013098[Immunoglobulin I-set] -- -- Q545R0 Catenin (Cadherin associated protein), alpha 1 Ctnna1 15240.7 14315.8 14501.8 14645.2 14886.2 14644.4 0.997340172673726 0.900348108400293 -0.00384243206448773 Nonsignificant None 2 Biological Process:cell adhesion (GO:0007155),Molecular Function:actin filament binding (GO:0051015) catenin alpha -- ko04390 Hippo signaling pathway ko04520 Adherens junction ko04670 Leukocyte transendothelial migration ko05100 Bacterial invasion of epithelial cells ko05200 Pathways in cancer ko05213 Endometrial cancer ko05226 Gastric cancer ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) Alpha-catenin W Extracellular structures ; IPR006077 [Vinculin/alpha-catenin] -- -- A0A0A0MQA5 Tubulin alpha chain (Fragment) Tuba4a 3237.6 3237.4 2964 2880.5 2906.1 2909 1.08549151294908 0.111486176904657 0.11834844610585 Nonsignificant None 1 Molecular Function:GTPase activity (GO:0003924) tubulin alpha -- ko04145 Phagosome ko04210 Apoptosis ko04530 Tight junction ko04540 Gap junction Alpha tubulin Z Cytoskeleton ; IPR003008 [Tubulin/FtsZ, GTPase domain] ; IPR018316[Tubulin/FtsZ, 2-layer sandwich domain] -- -- P27773 Protein disulfide-isomerase A3 Pdia3 36173.1 36360.1 37135.2 34836.6 34631.9 33739.1 1.06260004108225 0.00857073834548235 0.0875986737011019 Nonsignificant None 1 Biological Process:cell redox homeostasis (GO:0045454) protein disulfide isomerase family A, member 3 5.3.4.1 ko04141 Protein processing in endoplasmic reticulum ko04612 Antigen processing and presentation Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) O Posttranslational modification, protein turnover, chaperones ; IPR013766 [Thioredoxin domain] -- -- Q62468 Villin-1 Vil1 24869 23128.5 27448.5 26817.6 26503.8 26766.7 0.942037581113799 0.342671422147646 -0.0861434798422752 Nonsignificant None 2 Molecular Function:actin binding (GO:0003779),Biological Process:cytoskeleton organization (GO:0007010) villin 1 -- -- Actin regulatory proteins (gelsolin/villin family) Z Cytoskeleton ; IPR003128 [Villin headpiece] ; IPR007123[Gelsolin-like domain] -- -- S4R1W1 Glyceraldehyde-3-phosphate dehydrogenase Gm3839 536.9 723.4 857 750.6 842.7 646.1 0.94547646691078 0.727374661397417 -0.0808865452196084 Nonsignificant None 1 Biological Process:oxidation-reduction process (GO:0055114) glyceraldehyde 3-phosphate dehydrogenase 1.2.1.12 ko00010 Glycolysis / Gluconeogenesis ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids ko04066 HIF-1 signaling pathway ko05010 Alzheimer's disease Glyceraldehyde 3-phosphate dehydrogenase G Carbohydrate transport and metabolism ; IPR020828 [Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain] ; IPR020829[Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain] -- -- Q9D7Z6 Calcium-activated chloride channel regulator 1 Clca1 17202.4 13439.9 14243.5 31001.5 27191.9 29600.6 0.511262728660273 0.000857258722754934 -0.9678632383069 Significant down -- -- calcium-activated chloride channel regulator 1 -- ko04924 Renin secretion ko04972 Pancreatic secretion -- -- -- IPR002035 [von Willebrand factor, type A] ; IPR013642[Calcium-activated chloride channel protein] -- -- P09411 Phosphoglycerate kinase 1 Pgk1 23895.6 22239.7 21415.7 19377.2 20450.1 19615.1 1.1364110466603 0.0276553227742855 0.184484760649744 Nonsignificant None 2 Molecular Function:phosphoglycerate kinase activity (GO:0004618),Biological Process:glycolytic process (GO:0006096) phosphoglycerate kinase 2.7.2.3 ko00010 Glycolysis / Gluconeogenesis ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids 3-phosphoglycerate kinase G Carbohydrate transport and metabolism ; IPR001576 [Phosphoglycerate kinase] -- -- Q3UBU0 HATPase_c domain-containing protein Hsp90b1 36767.8 36251.2 36121.3 32157.7 32801.1 30995.2 1.13742314025471 0.00146356221837316 0.185769060546719 Nonsignificant None 4 Molecular Function:ATP binding (GO:0005524),Biological Process:protein folding (GO:0006457),Biological Process:response to stress (GO:0006950),Molecular Function:unfolded protein binding (GO:0051082) heat shock protein 90kDa beta -- ko04141 Protein processing in endoplasmic reticulum ko04151 PI3K-Akt signaling pathway ko04657 IL-17 signaling pathway ko04915 Estrogen signaling pathway ko04918 Thyroid hormone synthesis ko05200 Pathways in cancer ko05215 Prostate cancer ko05418 Fluid shear stress and atherosclerosis Endoplasmic reticulum glucose-regulated protein (GRP94/endoplasmin), HSP90 family O Posttranslational modification, protein turnover, chaperones ; IPR001404 [Heat shock protein Hsp90 family] ; IPR003594[Histidine kinase-like ATPase, C-terminal domain] -- -- P99024 Tubulin beta-5 chain Tubb5 3939.5 3616.4 3533.6 2834.3 2924.9 3178.6 1.24074156951375 0.0112268939438546 0.31120265196566 Nonsignificant None 1 Molecular Function:GTPase activity (GO:0003924) tubulin beta -- ko04145 Phagosome ko04540 Gap junction Beta tubulin Z Cytoskeleton ; IPR003008 [Tubulin/FtsZ, GTPase domain] ; IPR018316[Tubulin/FtsZ, 2-layer sandwich domain] -- -- P17563 Methanethiol oxidase Selenbp1 12068.2 11376 14840 25065.8 23407.9 26693.3 0.509321909880666 0.00098205838871641 -0.973350314827857 Significant down 1 Molecular Function:selenium binding (GO:0008430) selenium-binding protein 1 -- -- Selenium-binding protein P Inorganic ion transport and metabolism ; IPR008826 [Selenium-binding protein] -- -- A2AIM4 Tropomyosin beta chain Tpm2 110.8 110 129.7 161 147.4 144.6 0.773730684326711 0.0140177686230231 -0.370096606035612 Nonsignificant None -- -- tropomyosin 2 -- ko04260 Cardiac muscle contraction ko04261 Adrenergic signaling in cardiomyocytes ko05410 Hypertrophic cardiomyopathy (HCM) ko05414 Dilated cardiomyopathy (DCM) Actin filament-coating protein tropomyosin Z Cytoskeleton ; IPR000533 [Tropomyosin] -- -- P47856 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 Gfpt1 21084.1 20497.9 21842.7 27470.1 26626.1 26730.5 0.784699857844004 0.000250305702626886 -0.349787156044604 Nonsignificant None 2 Biological Process:carbohydrate metabolic process (GO:0005975),Molecular Function:carbohydrate binding (GO:0030246) glucosamine---fructose-6-phosphate aminotransferase (isomerizing) 2.6.1.16 ko00250 Alanine, aspartate and glutamate metabolism ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways ko04931 Insulin resistance Glucosamine 6-phosphate synthetases, contain amidotransferase and phosphosugar isomerase domains M Cell wall/membrane/envelope biogenesis ; IPR001347 [Sugar isomerase (SIS)] -- -- P68372 Tubulin beta-4B chain Tubb4b 1131.8 1124.8 1185.6 1075 1072 1171.6 1.03724462122582 0.338500642138508 0.0527561759360434 Nonsignificant None 1 Molecular Function:GTPase activity (GO:0003924) tubulin beta -- ko04145 Phagosome ko04540 Gap junction Beta tubulin Z Cytoskeleton ; IPR003008 [Tubulin/FtsZ, GTPase domain] ; IPR018316[Tubulin/FtsZ, 2-layer sandwich domain] -- -- Q3UDK4 Annexin Anxa6 454.9 440.3 443.2 377.5 377 399.6 1.15969153452907 0.00210837419481232 0.213741115020582 Nonsignificant None 2 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:calcium-dependent phospholipid binding (GO:0005544) annexin A6 -- -- Annexin U Intracellular trafficking, secretion, and vesicular transport ; IPR018502 [Annexin repeat] -- -- P09103 Protein disulfide-isomerase P4hb 32603.6 32433 28906.8 25112.6 25756.5 24242.8 1.2507126034623 0.00806901103750685 0.322750316127489 Nonsignificant None 1 Biological Process:cell redox homeostasis (GO:0045454) protein disulfide-isomerase A1 5.3.4.1 ko04141 Protein processing in endoplasmic reticulum Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) O Posttranslational modification, protein turnover, chaperones ; IPR013766 [Thioredoxin domain] -- -- Q3V3U0 Alpha-1,4 glucan phosphorylase Pygb 12202.3 11770.8 11687.2 12827.7 12542.7 12872.3 0.932473387077795 0.0105888221986889 -0.100865543652219 Nonsignificant None 2 Biological Process:carbohydrate metabolic process (GO:0005975),Molecular Function:glycogen phosphorylase activity (GO:0008184) glycogen phosphorylase 2.4.1.1 ko00500 Starch and sucrose metabolism ko01100 Metabolic pathways ko04217 Necroptosis ko04910 Insulin signaling pathway ko04922 Glucagon signaling pathway ko04931 Insulin resistance Glycogen phosphorylase G Carbohydrate transport and metabolism ; IPR000811 [Glycosyl transferase, family 35] -- -- Q8R0Y6 Cytosolic 10-formyltetrahydrofolate dehydrogenase Aldh1l1 11608 10774.7 11288.5 15783.7 17257.6 16581 0.678549764924238 0.000410149797232758 -0.559473467929166 Nonsignificant None 4 Biological Process:metabolic process (GO:0008152),Biological Process:biosynthetic process (GO:0009058),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) formyltetrahydrofolate dehydrogenase 1.5.1.6 ko00670 One carbon pool by folate Formyltetrahydrofolate dehydrogenase F Nucleotide transport and metabolism ; IPR002376 [Formyl transferase, N-terminal] ; IPR005793[Formyl transferase, C-terminal] ; IPR015590[Aldehyde dehydrogenase domain] -- -- Q62009 Periostin Postn 768.9 758.3 912.7 1012.8 982.6 941.1 0.830887110505704 0.0373712513208462 -0.267275618104766 Nonsignificant None -- -- -- -- -- Fasciclin and related adhesion glycoproteins MW Cell wall/membrane/envelope biogenesis ; Extracellular structures ; IPR000782 [FAS1 domain] -- -- E9QA15 Caldesmon 1 Cald1 1077.5 1289.6 687.2 858.7 810.9 670.4 1.30525641025641 0.268052283227802 0.384333243935735 Nonsignificant None -- -- caldesmon -- ko04270 Vascular smooth muscle contraction -- -- -- IPR006018 [Caldesmon/lymphocyte specific protein] -- -- Q3U4U1 Uncharacterized protein Postn 857.4 695.8 619 798.6 798.9 878.1 0.877443851995476 0.249180045991657 -0.18862128518456 Nonsignificant None -- -- -- -- -- Fasciclin and related adhesion glycoproteins MW Cell wall/membrane/envelope biogenesis ; Extracellular structures ; IPR000782 [FAS1 domain] -- -- P37804 Transgelin Tagln 37806.6 39097.7 36785.7 45589.3 41896.7 41265 0.883022267788211 0.0289694151024836 -0.179478275108125 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) transgelin -- -- Calponin Z Cytoskeleton ; IPR000557 [Calponin repeat] ; IPR001715[Calponin homology domain] -- -- Q5FWB7 Fructose-bisphosphate aldolase Aldoa 4968.6 4888.8 5029.9 5101.6 5187.2 4987 0.974567616753296 0.141954276015182 -0.0371658098962458 Nonsignificant None 2 Molecular Function:fructose-bisphosphate aldolase activity (GO:0004332),Biological Process:glycolytic process (GO:0006096) fructose-bisphosphate aldolase, class I 4.1.2.13 ko00010 Glycolysis / Gluconeogenesis ko00030 Pentose phosphate pathway ko00051 Fructose and mannose metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids Fructose-biphosphate aldolase G Carbohydrate transport and metabolism ; IPR000741 [Fructose-bisphosphate aldolase, class-I] -- -- P14733 Lamin-B1 Lmnb1 16292.7 16611.6 18246.9 17535.7 17255.8 17228.2 0.983304401986171 0.661453958519066 -0.0242899934247531 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) lamin B -- ko04210 Apoptosis Nuclear envelope protein lamin, intermediate filament superfamily DY Cell cycle control, cell division, chromosome partitioning ; Nuclear structure ; IPR001322 [Lamin Tail Domain] ; IPR001664[Intermediate filament protein] -- -- P38647 Stress-70 protein, mitochondrial Hspa9 26396.7 25491.9 23180.4 22157.8 22191.8 21751.5 1.1356694517943 0.0860752377915999 0.183542984797835 Nonsignificant None -- -- molecular chaperone DnaK -- ko03018 RNA degradation ko05152 Tuberculosis Molecular chaperones mortalin/PBP74/GRP75, HSP70 superfamily O Posttranslational modification, protein turnover, chaperones ; IPR013126 [Heat shock protein 70 family] -- -- Q80YX1 Tenascin Tnc 18613.5 21246 19204.5 16440.1 14790.3 14696.3 1.28604929158855 0.0110121254282464 0.362945939219161 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) tenascin -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko05165 Human papillomavirus infection ko05206 MicroRNAs in cancer Teneurin-1 and related extracellular matrix proteins, contain EGF-like repeats TW Signal transduction mechanisms ; Extracellular structures ; IPR002181 [Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain] ; IPR003961[Fibronectin type III] ; IPR013111[EGF-like domain, extracellular] -- -- Q70IV5 Synemin Synm 7075.2 7150.5 7564.2 9768.7 9273.4 8628.8 0.787466255163367 0.00570937558989733 -0.344709993040214 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) desmuslin -- -- -- -- -- IPR001664 [Intermediate filament protein] -- -- Q564G1 Tropomyosin 1, alpha Tpm1 971.6 986.6 624.8 610.6 658.7 554.6 1.41619606338067 0.106632049568236 0.502021011244371 Nonsignificant None -- -- tropomyosin 1 -- ko04260 Cardiac muscle contraction ko04261 Adrenergic signaling in cardiomyocytes ko05206 MicroRNAs in cancer ko05410 Hypertrophic cardiomyopathy (HCM) ko05414 Dilated cardiomyopathy (DCM) Actin filament-coating protein tropomyosin Z Cytoskeleton ; IPR000533 [Tropomyosin] -- -- Q3V117 ATP-citrate synthase Acly 695.8 694.4 483.6 880.3 1014 892.8 0.672311721861433 0.0209271090215712 -0.572797791481912 Nonsignificant None 3 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152),Molecular Function:cofactor binding (GO:0048037) ATP citrate (pro-S)-lyase 2.3.3.8 ko00020 Citrate cycle (TCA cycle) ko01100 Metabolic pathways ATP-citrate lyase C Energy production and conversion ; IPR002020 [Citrate synthase] ; IPR003781[CoA-binding] ; IPR005811[ATP-citrate lyase/succinyl-CoA ligase] ; IPR032263[ATP-citrate synthase, citrate-binding domain] -- -- A0A1L1SQ51 Talin-2 Tln2 6178.1 6068 6337.7 6643.9 6479.1 6794.6 0.933034100494035 0.0208147983410898 -0.0999982852844892 Nonsignificant None 5 Cellular Component:ruffle (GO:0001726),Molecular Function:actin binding (GO:0003779),Molecular Function:structural constituent of cytoskeleton (GO:0005200),Cellular Component:focal adhesion (GO:0005925),Biological Process:cytoskeletal anchoring at plasma membrane (GO:0007016) talin -- ko04015 Rap1 signaling pathway ko04510 Focal adhesion ko04611 Platelet activation ko05166 HTLV-I infection Talin Z Cytoskeleton ; IPR002558 [I/LWEQ domain] ; IPR015009[Vinculin-binding site-containing domain] ; IPR015224[Talin, central] ; IPR018979[FERM, N-terminal] ; IPR019748[FERM central domain] ; IPR032425[Talin, N-terminal F0 domain] -- -- E9QA16 Caldesmon 1 Cald1 987.6 1071 870.7 589.8 678.8 742.3 1.45671092545626 0.0137734282733385 0.542714612619999 Nonsignificant None -- -- caldesmon -- ko04270 Vascular smooth muscle contraction -- -- -- IPR006018 [Caldesmon/lymphocyte specific protein] -- -- O55143 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Atp2a2 13176.7 12955.4 14591.1 14346 13618.2 13586.1 0.980094006541469 0.653491353188301 -0.029007961713808 Nonsignificant None 2 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:metal ion binding (GO:0046872) Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum 3.6.3.8 ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04972 Pancreatic secretion ko05010 Alzheimer's disease Ca2+ transporting ATPase P Inorganic ion transport and metabolism ; IPR004014 [Cation-transporting P-type ATPase, N-terminal] ; IPR006068[Cation-transporting P-type ATPase, C-terminal] ; IPR008250[P-type ATPase, A domain] ; IPR023214[HAD-like domain] -- -- F8VQJ3 Laminin subunit gamma-1 Lamc1 18103.1 18024.5 20336.5 20802.9 21025.3 21616 0.889980486789967 0.0430815295136494 -0.168154390179072 Nonsignificant None -- -- laminin, gamma 1 -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko05020 Prion diseases ko05145 Toxoplasmosis ko05146 Amoebiasis ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05222 Small cell lung cancer Extracellular matrix glycoprotein Laminin subunits alpha and gamma W Extracellular structures ; IPR000034 [Laminin IV] ; IPR002049[Laminin EGF domain] ; IPR008211[Laminin, N-terminal] -- -- Q3TED3 ATP-citrate synthase Acly 400.9 383.6 322.8 454.7 495.7 507.3 0.759621321259519 0.0149723066396356 -0.396647694871677 Nonsignificant None 3 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152),Molecular Function:cofactor binding (GO:0048037) ATP citrate (pro-S)-lyase 2.3.3.8 ko00020 Citrate cycle (TCA cycle) ko01100 Metabolic pathways ATP-citrate lyase C Energy production and conversion ; IPR002020 [Citrate synthase] ; IPR003781[CoA-binding] ; IPR005811[ATP-citrate lyase/succinyl-CoA ligase] ; IPR032263[ATP-citrate synthase, citrate-binding domain] -- -- Q78PY7 Staphylococcal nuclease domain-containing protein 1 Snd1 14811.4 15067.9 13638 12157.3 12967.2 12091 1.16933267052707 0.015867219104052 0.225685429306997 Nonsignificant None -- -- staphylococcal nuclease domain-containing protein 1 -- ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis Transcriptional coactivator p100 K Transcription ; IPR002999 [Tudor domain] ; IPR016071[Staphylococcal nuclease (SNase-like), OB-fold] -- -- Q8CIE6 Coatomer subunit alpha Copa 17047.3 16959.5 17885.9 17888.6 17913 17711.1 0.969726812513665 0.148316614612408 -0.0443497205178795 Nonsignificant None 6 Molecular Function:structural molecule activity (GO:0005198),Molecular Function:protein binding (GO:0005515),Biological Process:intracellular protein transport (GO:0006886),Biological Process:vesicle-mediated transport (GO:0016192),Cellular Component:membrane coat (GO:0030117),Cellular Component:COPI vesicle coat (GO:0030126) coatomer subunit alpha -- -- Vesicle coat complex COPI, alpha subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR001680 [WD40 repeat] ; IPR006692[Coatomer, WD associated region] ; IPR010714[Coatomer, alpha subunit, C-terminal] ; IPR024977[Anaphase-promoting complex subunit 4, WD40 domain] -- -- Q571M2 Heat shock 70 kDa protein 4 (Fragment) Hspa4 15254.7 15460.9 14450.7 13905 14187.2 13486.6 1.08628195137907 0.0317325306321123 0.119398612407409 Nonsignificant None -- -- heat shock 70kDa protein 4 -- ko04530 Tight junction ko04612 Antigen processing and presentation Molecular chaperones HSP105/HSP110/SSE1, HSP70 superfamily O Posttranslational modification, protein turnover, chaperones ; IPR013126 [Heat shock protein 70 family] -- -- Q04447 Creatine kinase B-type Ckb 13898.2 14501 15834.3 15832 14965.3 15297.8 0.959613928595447 0.377144507858832 -0.0594739966872963 Nonsignificant None 1 Molecular Function:kinase activity (GO:0016301) creatine kinase 2.7.3.2 ko00330 Arginine and proline metabolism ko01100 Metabolic pathways Creatine kinases C Energy production and conversion ; IPR022413 [ATP:guanido phosphotransferase, N-terminal] ; IPR022414[ATP:guanido phosphotransferase, catalytic domain] -- -- Q8K419 Galectin-4 Lgals4 17066.5 15609.9 15074.6 16122.6 16181 17812.1 0.952815185660382 0.38712121912017 -0.0697316882949691 Nonsignificant None 1 Molecular Function:carbohydrate binding (GO:0030246) galectin-4 -- -- Galectin, galactose-binding lectin W Extracellular structures ; IPR001079 [Galectin, carbohydrate recognition domain] -- -- A0A0R4J034 Pyridoxal-dependent decarboxylase domain-containing protein 1 Pdxdc1 10745.2 10303.4 12006.5 14349.7 14423.6 14113.9 0.770745117424313 0.00321053921172302 -0.375674249821914 Nonsignificant None 3 Molecular Function:carboxy-lyase activity (GO:0016831),Biological Process:carboxylic acid metabolic process (GO:0019752),Molecular Function:pyridoxal phosphate binding (GO:0030170) -- -- -- Predicted pyridoxal-dependent decarboxylase E Amino acid transport and metabolism ; IPR002129 [Pyridoxal phosphate-dependent decarboxylase] -- -- B7ZNH7 Collagen alpha-1(XIV) chain Col14a1 13750.9 14539.5 13441.5 14780.6 15274.4 16268.5 0.900879683098212 0.0486934371501479 -0.150593654984286 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) collagen, type XIV, alpha -- ko04974 Protein digestion and absorption Collagens (type IV and type XIII), and related proteins W Extracellular structures ; IPR002035 [von Willebrand factor, type A] ; IPR003961[Fibronectin type III] ; IPR008160[Collagen triple helix repeat] -- -- B2RSH3 Calponin Cnn1 20871.7 22790 20313.9 27214.7 22984.5 21745.7 0.88923050834736 0.217666479244341 -0.169370648674508 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Calponin Z Cytoskeleton ; IPR000557 [Calponin repeat] ; IPR001715[Calponin homology domain] -- -- P05784 Keratin, type I cytoskeletal 18 Krt18 18002.7 16955.2 16743.2 18737.9 17920.2 18811.8 0.932056845243997 0.0599555114249709 -0.101510148751695 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) type I keratin, acidic -- -- -- -- -- IPR001664 [Intermediate filament protein] -- -- Q7TMM9 Tubulin beta-2A chain Tubb2a 284.7 266.1 336 323.4 277.3 296.1 0.988849241748439 0.899647066116831 -0.0161775079381196 Nonsignificant None 1 Molecular Function:GTPase activity (GO:0003924) tubulin beta -- ko04145 Phagosome ko04540 Gap junction Beta tubulin Z Cytoskeleton ; IPR003008 [Tubulin/FtsZ, GTPase domain] ; IPR018316[Tubulin/FtsZ, 2-layer sandwich domain] -- -- P47738 Aldehyde dehydrogenase, mitochondrial Aldh2 14050.5 13296.9 11384.7 17327.5 16613.6 18295.9 0.741468690774738 0.00843542760163589 -0.431542320100473 Nonsignificant None 3 Biological Process:metabolic process (GO:0008152),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) aldehyde dehydrogenase (NAD+) 1.2.1.3 ko00010 Glycolysis / Gluconeogenesis ko00053 Ascorbate and aldarate metabolism ko00071 Fatty acid degradation ko00280 Valine, leucine and isoleucine degradation ko00310 Lysine degradation ko00330 Arginine and proline metabolism ko00340 Histidine metabolism ko00380 Tryptophan metabolism ko00410 beta-Alanine metabolism ko00561 Glycerolipid metabolism ko00620 Pyruvate metabolism ko01100 Metabolic pathways Aldehyde dehydrogenase C Energy production and conversion ; IPR015590 [Aldehyde dehydrogenase domain] -- -- Q9CWF2 Tubulin beta-2B chain Tubb2b 113.5 110.7 155.5 124.6 113.2 119.1 1.0638834407397 0.635946334215065 0.0893400975700663 Nonsignificant None 1 Molecular Function:GTPase activity (GO:0003924) tubulin beta -- ko04145 Phagosome ko04540 Gap junction Beta tubulin Z Cytoskeleton ; IPR003008 [Tubulin/FtsZ, GTPase domain] ; IPR018316[Tubulin/FtsZ, 2-layer sandwich domain] -- -- Q9QZE5 Coatomer subunit gamma-1 Copg1 9034.9 8989.8 9088 9044.5 9264.5 8911.2 0.9960507270336 0.75419331471385 -0.00570887691506243 Nonsignificant None 5 Molecular Function:structural molecule activity (GO:0005198),Biological Process:intracellular protein transport (GO:0006886),Biological Process:vesicle-mediated transport (GO:0016192),Cellular Component:membrane coat (GO:0030117),Cellular Component:COPI vesicle coat (GO:0030126) coatomer subunit gamma -- -- Vesicle coat complex COPI, gamma subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR002553 [Clathrin/coatomer adaptor, adaptin-like, N-terminal] ; IPR013040[Coatomer, gamma subunit, appendage, Ig-like subdomain] ; IPR032154[Coatomer subunit gamma, C-terminal] -- -- Q542X7 T-complex protein 1 subunit beta Cct2 13433 14129.6 13239 11828.8 12178.6 12049.5 1.13158923812086 0.00542784974434104 0.178350361288747 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) T-complex protein 1 subunit beta -- -- Chaperonin complex component, TCP-1 beta subunit (CCT2) O Posttranslational modification, protein turnover, chaperones ; IPR002423 [Chaperonin Cpn60/TCP-1 family] -- -- Q8CGC7 Bifunctional glutamate/proline--tRNA ligase Eprs1 12587.6 12666.3 12579.3 12581.2 12583.6 12167.5 1.0134173356584 0.302062908187753 0.0192284131269179 Nonsignificant None 8 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:proline-tRNA ligase activity (GO:0004827),Molecular Function:ATP binding (GO:0005524),Cellular Component:cytoplasm (GO:0005737),Biological Process:tRNA aminoacylation for protein translation (GO:0006418),Biological Process:prolyl-tRNA aminoacylation (GO:0006433),Biological Process:tRNA aminoacylation (GO:0043039) -- -- ko00860 Porphyrin and chlorophyll metabolism ko00970 Aminoacyl-tRNA biosynthesis ko01100 Metabolic pathways Glutamyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR000738 [WHEP-TRS domain] ; IPR002314[Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)] ; IPR004046[Glutathione S-transferase, C-terminal] ; IPR004154[Anticodon-binding] ; IPR016061[Proline-tRNA ligase, class II, C-terminal] ; IPR020058[Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain] ; IPR020059[Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain] -- -- P17879 Heat shock 70 kDa protein 1B Hspa1b 10125.4 10635 8356.9 10393.5 10464.4 10041.4 0.942328790619852 0.44546037402131 -0.0856975723798093 Nonsignificant None -- -- heat shock 70kDa protein 1/2/6/8 -- ko03040 Spliceosome ko04010 MAPK signaling pathway ko04141 Protein processing in endoplasmic reticulum ko04144 Endocytosis ko04213 Longevity regulating pathway - multiple species ko04612 Antigen processing and presentation ko04915 Estrogen signaling pathway ko05134 Legionellosis ko05145 Toxoplasmosis ko05162 Measles ko05164 Influenza A ko05169 Epstein-Barr virus infection Molecular chaperones HSP70/HSC70, HSP70 superfamily O Posttranslational modification, protein turnover, chaperones ; IPR013126 [Heat shock protein 70 family] -- -- Q8BMS1 Trifunctional enzyme subunit alpha, mitochondrial Hadha 13293.5 12706.9 15300.5 15432.3 14733.3 15561.9 0.903196107375212 0.148703996022482 -0.146888826538384 Nonsignificant None 6 Molecular Function:catalytic activity (GO:0003824),Molecular Function:3-hydroxyacyl-CoA dehydrogenase activity (GO:0003857),Biological Process:fatty acid metabolic process (GO:0006631),Biological Process:metabolic process (GO:0008152),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00062 Fatty acid elongation ko00071 Fatty acid degradation ko00280 Valine, leucine and isoleucine degradation ko00310 Lysine degradation ko00380 Tryptophan metabolism ko00410 beta-Alanine metabolism ko00640 Propanoate metabolism ko00650 Butanoate metabolism ko01040 Biosynthesis of unsaturated fatty acids ko01100 Metabolic pathways ko01200 Carbon metabolism ko01212 Fatty acid metabolism Hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase I Lipid transport and metabolism ; IPR001753 [Crotonase superfamily] ; IPR006108[3-hydroxyacyl-CoA dehydrogenase, C-terminal] ; IPR006176[3-hydroxyacyl-CoA dehydrogenase, NAD binding] -- -- Q3UXR4 FERM domain-containing protein Ezr 16868.5 15682.9 14054.5 16297 16215.4 15708.5 0.966508298269008 0.554765355466887 -0.0491459756736644 Nonsignificant None 3 Cellular Component:cytoplasm (GO:0005737),Molecular Function:cytoskeletal protein binding (GO:0008092),Cellular Component:extrinsic component of membrane (GO:0019898) villin 2 (ezrin) -- ko04530 Tight junction ko04670 Leukocyte transendothelial migration ko04810 Regulation of actin cytoskeleton ko04971 Gastric acid secretion ko05205 Proteoglycans in cancer ko05206 MicroRNAs in cancer Radixin, moesin and related proteins of the ERM family R General function prediction only ; IPR011259 [Ezrin/radixin/moesin, C-terminal] ; IPR018979[FERM, N-terminal] ; IPR018980[FERM, C-terminal PH-like domain] ; IPR019748[FERM central domain] -- -- Q61001 Laminin subunit alpha-5 Lama5 7735.4 7786.5 8259.6 8978.8 8634.5 8948.1 0.895340607046315 0.00976156307471886 -0.159491475508642 Nonsignificant None 5 Molecular Function:receptor binding (GO:0005102),Biological Process:cell adhesion (GO:0007155),Biological Process:regulation of cell adhesion (GO:0030155),Biological Process:regulation of cell migration (GO:0030334),Biological Process:regulation of embryonic development (GO:0045995) laminin, alpha 3/5 -- ko01100 Metabolic pathways ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko05145 Toxoplasmosis ko05146 Amoebiasis ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05222 Small cell lung cancer Extracellular matrix glycoprotein Laminin subunits alpha and gamma W Extracellular structures ; IPR000034 [Laminin IV] ; IPR001791[Laminin G domain] ; IPR002049[Laminin EGF domain] ; IPR008211[Laminin, N-terminal] ; IPR009254[Laminin alpha, domain I] ; IPR010307[Laminin domain II] -- -- Q8VDJ3 Vigilin Hdlbp 17550.8 17086.1 17649.4 16249.2 16486.8 15450.8 1.08507516581304 0.0188690156542348 0.117794985148683 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) -- -- -- Vigilin I Lipid transport and metabolism ; IPR004088 [K Homology domain, type 1] -- -- Q6ZPS0 MKIAA1398 protein (Fragment) Rrbp1 2378 2420.5 2809.4 2292.9 1726.1 2222.1 1.21899985579465 0.112895523425898 0.285697955290075 Nonsignificant None -- -- ribosome-binding protein 1 -- ko04141 Protein processing in endoplasmic reticulum -- -- -- -- -- -- Q3TWG9 Serpin H1 Serpinh1 22504.2 23516.8 21041.2 20093.2 20433.5 17858 1.14862626681305 0.05549200030137 0.199909458798651 Nonsignificant None -- -- serpin peptidase inhibitor, clade H, member 1 -- -- Serpin V Defense mechanisms ; IPR023796 [Serpin domain] -- -- Q8BWT1 3-ketoacyl-CoA thiolase, mitochondrial Acaa2 10201.1 9988.5 14157.5 12592.4 11265.9 12994.3 0.932012938028796 0.596149784479717 -0.101578112646835 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) acetyl-CoA acyltransferase 2 2.3.1.16 ko00062 Fatty acid elongation ko00071 Fatty acid degradation ko00280 Valine, leucine and isoleucine degradation ko01100 Metabolic pathways ko01212 Fatty acid metabolism Acetyl-CoA acetyltransferase I Lipid transport and metabolism ; IPR020616 [Thiolase, N-terminal] ; IPR020617[Thiolase, C-terminal] -- -- P11983 T-complex protein 1 subunit alpha Tcp1 11401.1 11333.8 11155.8 10160.1 9963.9 10282 1.11460566993357 0.000598669457600224 0.156533397452244 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) T-complex protein 1 subunit alpha -- -- Chaperonin complex component, TCP-1 alpha subunit (CCT1) O Posttranslational modification, protein turnover, chaperones ; IPR002423 [Chaperonin Cpn60/TCP-1 family] -- -- Q6P4T2 U5 small nuclear ribonucleoprotein 200 kDa helicase Snrnp200 9576.2 9691 9760.6 9080.4 9227.4 9196.1 1.05540668777882 0.0019067265576065 0.0777990305754232 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) pre-mRNA-splicing helicase BRR2 3.6.4.13 ko03040 Spliceosome RNA helicase BRR2, DEAD-box superfamily A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR004179[Sec63 domain] ; IPR011545[DEAD/DEAH box helicase domain] -- -- A2AVJ7 Ribosome-binding protein 1 Rrbp1 1141.7 1092.8 1115 929.5 1054.5 842.6 1.18499257057949 0.0507369207005532 0.244878014041915 Nonsignificant None 2 Biological Process:protein transport (GO:0015031),Cellular Component:integral component of endoplasmic reticulum membrane (GO:0030176) ribosome-binding protein 1 -- ko04141 Protein processing in endoplasmic reticulum -- -- -- IPR007794 [Ribosome receptor lysine/proline rich] -- -- E9Q175 Unconventional myosin-VI Myo6 16605.6 15816.9 16683.6 16262.7 17200.4 17046.9 0.972205503860622 0.308232312556512 -0.0406667933365227 Nonsignificant None 3 Molecular Function:motor activity (GO:0003774),Molecular Function:ATP binding (GO:0005524),Cellular Component:myosin complex (GO:0016459) myosin VI -- -- Myosin class VI heavy chain Z Cytoskeleton ; IPR001609 [Myosin head, motor domain] ; IPR032412[Myosin VI, cargo binding domain] -- -- Q3ULH5 Uncharacterized protein Hnrnpu 22550.9 22907.9 21176.9 19569.2 19168.5 19780.3 1.13872141905055 0.00830863292777199 0.18741484405016 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) heterogeneous nuclear ribonucleoprotein U -- ko03040 Spliceosome Scaffold/matrix specific factor hnRNP-U/SAF-A, contains SPRY domain A RNA processing and modification ; IPR003034 [SAP domain] ; IPR003877[SPRY domain] -- -- E9QNN1 RNA helicase Dhx9 11341.1 11334.7 11656.4 11431.7 11245.7 11344.9 1.00910873162602 0.43435093938663 0.0130816334394602 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:helicase activity (GO:0004386),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase A 3.6.4.13 -- Dosage compensation complex, subunit MLE K Transcription ; IPR001650 [Helicase, C-terminal] ; IPR007502[Helicase-associated domain] ; IPR011545[DEAD/DEAH box helicase domain] ; IPR011709[Domain of unknown function DUF1605] ; IPR014720[Double-stranded RNA-binding domain] -- -- Q8CAQ8 MICOS complex subunit Mic60 Immt 3184.3 3252.9 4197.1 4485.7 4399.3 4546.8 0.79172560639676 0.10157645145134 -0.336927582362436 Nonsignificant None -- -- mitofilin -- -- Mitochondrial inner membrane protein (mitofilin) M Cell wall/membrane/envelope biogenesis ; IPR019133 [Mitochondrial inner membrane protein Mitofilin] -- -- Q9R100 Cadherin-17 Cdh17 12675.9 11514.7 13093.1 15409.3 15900.2 15063.6 0.803994125904889 0.0046624909983756 -0.314743133979234 Nonsignificant None 3 Molecular Function:calcium ion binding (GO:0005509),Biological Process:homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156),Cellular Component:membrane (GO:0016020) cadherin 17, LI cadherin -- ko05226 Gastric cancer FOG: Cadherin repeats S Function unknown ; IPR002126 [Cadherin] -- -- Q3UPA3 Rab GDP dissociation inhibitor (Fragment) Gdi2 11467.6 11268.4 12247.7 11891.3 11182.4 12166.9 0.99271011276766 0.847917147653007 -0.0105556056632914 Nonsignificant None 2 Molecular Function:GDP-dissociation inhibitor activity (GO:0005092),Biological Process:small GTPase mediated signal transduction (GO:0007264) Rab GDP dissociation inhibitor -- -- RAB proteins geranylgeranyltransferase component A (RAB escort protein) O Posttranslational modification, protein turnover, chaperones ; IPR018203 [GDP dissociation inhibitor] -- -- Q02257 Junction plakoglobin Jup 8506.7 7867.8 8825.4 9178.1 8926 8790.1 0.937001286522745 0.136382692950234 -0.0938770661504887 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) junction plakoglobin -- ko05200 Pathways in cancer ko05202 Transcriptional misregulation in cancer ko05221 Acute myeloid leukemia ko05226 Gastric cancer ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) Armadillo/beta-Catenin/plakoglobin TZ Signal transduction mechanisms ; Cytoskeleton ; IPR000225 [Armadillo] -- -- O88329 Unconventional myosin-Ia Myo1a 9094.6 8500.7 9535.3 11949.9 12253.3 12107.8 0.747173032965217 0.000607955332899415 -0.420485708776384 Nonsignificant None 4 Molecular Function:motor activity (GO:0003774),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Cellular Component:myosin complex (GO:0016459) myosin I -- -- Myosin class I heavy chain Z Cytoskeleton ; IPR000048 [IQ motif, EF-hand binding site] ; IPR001609[Myosin head, motor domain] ; IPR010926[Class I myosin tail homology domain] -- -- Q61292 Laminin subunit beta-2 Lamb2 8920.9 9017 9907.3 11384.5 10800.4 11044.4 0.837971308453684 0.0073319548361006 -0.25502724697731 Nonsignificant None -- -- laminin, beta 2 -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko05145 Toxoplasmosis ko05146 Amoebiasis ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05222 Small cell lung cancer Extracellular matrix glycoprotein Laminin subunit beta W Extracellular structures ; IPR002049 [Laminin EGF domain] ; IPR008211[Laminin, N-terminal] -- -- E9QN70 Laminin subunit beta-1 Lamb1 11288.9 11999.8 11180.6 10642.7 10842 10939.8 1.06306342426252 0.0659509896622093 0.0882276731995628 Nonsignificant None -- -- laminin, beta 1 -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko05145 Toxoplasmosis ko05146 Amoebiasis ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05222 Small cell lung cancer Extracellular matrix glycoprotein Laminin subunit beta W Extracellular structures ; IPR002049 [Laminin EGF domain] ; IPR008211[Laminin, N-terminal] -- -- Q9CWJ9 Bifunctional purine biosynthesis protein ATIC Atic 9019.2 8934.1 9316.9 9147.3 9347.9 9118.9 0.987546217331001 0.448600636202585 -0.0180798267568872 Nonsignificant None 3 Molecular Function:IMP cyclohydrolase activity (GO:0003937),Molecular Function:phosphoribosylaminoimidazolecarboxamide formyltransferase activity (GO:0004643),Biological Process:purine nucleotide biosynthetic process (GO:0006164) -- -- ko00230 Purine metabolism ko00670 One carbon pool by folate ko01100 Metabolic pathways ko01523 Antifolate resistance AICAR transformylase/IMP cyclohydrolase/methylglyoxal synthase F Nucleotide transport and metabolism ; IPR002695 [AICARFT/IMPCHase bienzyme] ; IPR011607[Methylglyoxal synthase-like domain] -- -- Q61838 Pregnancy zone protein Pzp 15383 15952.2 13454.7 8895.8 10123.1 9241 1.5849277598293 0.00278670396919349 0.66441708458478 Significant up 3 Molecular Function:endopeptidase inhibitor activity (GO:0004866),Cellular Component:extracellular region (GO:0005576),Cellular Component:extracellular space (GO:0005615) -- -- -- Alpha-macroglobulin O Posttranslational modification, protein turnover, chaperones ; IPR001599 [Alpha-2-macroglobulin] ; IPR002890[Alpha-2-macroglobulin, N-terminal] ; IPR009048[Alpha-macroglobulin, receptor-binding] ; IPR011625[Alpha-2-macroglobulin, N-terminal 2] ; IPR011626[Alpha-macroglobulin complement component] ; IPR019565[Alpha-2-macroglobulin, thiol-ester bond-forming] -- -- O08528 Hexokinase-2 Hk2 11241 12193.2 10480.8 9073 9484.8 9034.8 1.22913389821909 0.0150346355560181 0.297642087211275 Nonsignificant None 2 Molecular Function:ATP binding (GO:0005524),Biological Process:carbohydrate metabolic process (GO:0005975) hexokinase 2.7.1.1 ko00010 Glycolysis / Gluconeogenesis ko00051 Fructose and mannose metabolism ko00052 Galactose metabolism ko00500 Starch and sucrose metabolism ko00520 Amino sugar and nucleotide sugar metabolism ko00524 Neomycin, kanamycin and gentamicin biosynthesis ko01100 Metabolic pathways ko01200 Carbon metabolism ko04066 HIF-1 signaling pathway ko04910 Insulin signaling pathway ko04930 Type II diabetes mellitus ko04973 Carbohydrate digestion and absorption ko05230 Central carbon metabolism in cancer Hexokinase G Carbohydrate transport and metabolism ; IPR022672 [Hexokinase, N-terminal] ; IPR022673[Hexokinase, C-terminal] -- -- Q9D6F9 Tubulin beta-4A chain Tubb4a 197 205.6 244.3 307.1 293.5 267.3 0.745362368936513 0.0168345496549672 -0.42398611123665 Nonsignificant None 1 Molecular Function:GTPase activity (GO:0003924) tubulin beta -- ko04145 Phagosome ko04540 Gap junction Beta tubulin Z Cytoskeleton ; IPR003008 [Tubulin/FtsZ, GTPase domain] ; IPR018316[Tubulin/FtsZ, 2-layer sandwich domain] -- -- Q9JIF7 Coatomer subunit beta Copb1 10648.1 10625.3 10400.5 10739.5 10385.1 10661.9 0.996457615654445 0.792477628129819 -0.00511965358176936 Nonsignificant None 5 Molecular Function:structural molecule activity (GO:0005198),Biological Process:intracellular protein transport (GO:0006886),Biological Process:vesicle-mediated transport (GO:0016192),Cellular Component:membrane coat (GO:0030117),Cellular Component:COPI vesicle coat (GO:0030126) coatomer subunit beta -- -- Vesicle coat complex COPI, beta subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR002553 [Clathrin/coatomer adaptor, adaptin-like, N-terminal] ; IPR011710[Coatomer beta subunit, C-terminal] ; IPR029446[Coatomer beta subunit, appendage platform domain] -- -- Q8BKC5 Importin-5 Ipo5 8419.8 8517.5 8184.4 6888 6605.5 7399.6 1.2023921773217 0.00505312871445083 0.265907528325745 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) importin-5 -- -- Karyopherin (importin) beta 3 YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; IPR000357 [HEAT repeat] -- -- Q3TWL6 26S proteasome non-ATPase regulatory subunit 2 Psmd2 11550.2 11178.2 11676.5 10389.7 10715 10498.4 1.08865585970997 0.00624923709951758 0.122547968788165 Nonsignificant None -- -- 26S proteasome regulatory subunit N1 -- ko03050 Proteasome ko05169 Epstein-Barr virus infection 26S proteasome regulatory complex, subunit RPN1/PSMD2 O Posttranslational modification, protein turnover, chaperones ; IPR002015 [Proteasome/cyclosome repeat] -- -- P21981 Protein-glutamine gamma-glutamyltransferase 2 Tgm2 11510.3 13359.3 11909.5 10247.8 9506.5 10554.3 1.21348726104142 0.0283313362985502 0.279158963430262 Nonsignificant None 2 Molecular Function:protein-glutamine gamma-glutamyltransferase activity (GO:0003810),Biological Process:peptide cross-linking (GO:0018149) transglutaminase 2 2.3.2.13 ko05016 Huntington's disease -- -- -- IPR001102 [Transglutaminase, N-terminal] ; IPR002931[Transglutaminase-like] ; IPR008958[Transglutaminase, C-terminal] -- -- O88569 Heterogeneous nuclear ribonucleoproteins A2/B1 Hnrnpa2b1 16281 16478.2 17251 17790.5 17837.4 17484.6 0.941590021181454 0.0307135128038094 -0.0868290638783744 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) heterogeneous nuclear ribonucleoprotein A2/B1 -- -- FOG: RRM domain R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- P23116 Eukaryotic translation initiation factor 3 subunit A Eif3a 15982.5 16241.7 16031.3 14655.4 14864.7 14566.2 1.09456906113691 0.000306914218299504 0.13036298331419 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) translation initiation factor 3 subunit A -- ko03013 RNA transport Translation initiation factor 3, subunit a (eIF-3a) J Translation, ribosomal structure and biogenesis ; IPR000717 [Proteasome component (PCI) domain] -- -- A0A0U1RQ96 Actin, gamma-enteric smooth muscle (Fragment) Actg2 96.1 84.9 134.6 62.5 77.1 70.8 1.5 0.0883282362067554 0.584962500721156 Nonsignificant None -- -- actin, aortic smooth muscle -- ko04270 Vascular smooth muscle contraction ko04371 Apelin signaling pathway ko04926 Relaxin signaling pathway Actin and related proteins Z Cytoskeleton ; IPR004000 [Actin family] -- -- Q9CZS1 Aldehyde dehydrogenase X, mitochondrial Aldh1b1 9635.5 8565.6 13360.7 13669.3 12901.9 15171.4 0.75610527374912 0.10104599632749 -0.40334097771324 Nonsignificant None 3 Biological Process:metabolic process (GO:0008152),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) aldehyde dehydrogenase (NAD+) 1.2.1.3 ko00010 Glycolysis / Gluconeogenesis ko00053 Ascorbate and aldarate metabolism ko00071 Fatty acid degradation ko00280 Valine, leucine and isoleucine degradation ko00310 Lysine degradation ko00330 Arginine and proline metabolism ko00340 Histidine metabolism ko00380 Tryptophan metabolism ko00410 beta-Alanine metabolism ko00561 Glycerolipid metabolism ko00620 Pyruvate metabolism ko01100 Metabolic pathways Aldehyde dehydrogenase C Energy production and conversion ; IPR015590 [Aldehyde dehydrogenase domain] -- -- Q04857 Collagen alpha-1(VI) chain Col6a1 14073 14242.2 14871.6 17922 17496.1 18035 0.807938173838374 0.000307978337806871 -0.307683197590353 Nonsignificant None -- -- collagen, type VI, alpha -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04974 Protein digestion and absorption ko05165 Human papillomavirus infection Collagens (type IV and type XIII), and related proteins W Extracellular structures ; IPR002035 [von Willebrand factor, type A] ; IPR008160[Collagen triple helix repeat] -- -- A0A0R4J0Z1 Protein disulfide-isomerase A4 Pdia4 15261.1 14821.3 16162.4 15043.3 15057.5 14811.4 1.02967122519048 0.331891328182318 0.0421837573066917 Nonsignificant None 1 Biological Process:cell redox homeostasis (GO:0045454) protein disulfide-isomerase A4 5.3.4.1 ko04141 Protein processing in endoplasmic reticulum ko04918 Thyroid hormone synthesis Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) O Posttranslational modification, protein turnover, chaperones ; IPR013766 [Thioredoxin domain] -- -- Q6P5E4 UDP-glucose:glycoprotein glucosyltransferase 1 Uggt1 8795.9 8841.3 8886.1 8753.5 8884.6 9054.6 0.99365369557969 0.568395529964036 -0.00918495811095709 Nonsignificant None 2 Molecular Function:UDP-glucose:glycoprotein glucosyltransferase activity (GO:0003980),Biological Process:protein glycosylation (GO:0006486) UDP-glucose:glycoprotein glucosyltransferase 2.4.1.- ko04141 Protein processing in endoplasmic reticulum UDP-glucose:glycoprotein glucosyltransferase G Carbohydrate transport and metabolism ; IPR009448 [UDP-glucose:Glycoprotein Glucosyltransferase] -- -- Q545N7 Creatine kinase Ckmt1 12886.5 12632.6 12224.1 19088.2 19476.9 19575.1 0.649175613430982 0.00000979922270870073 -0.62331928946081 Significant down 1 Molecular Function:kinase activity (GO:0016301) creatine kinase 2.7.3.2 ko00330 Arginine and proline metabolism ko01100 Metabolic pathways Creatine kinases C Energy production and conversion ; IPR022413 [ATP:guanido phosphotransferase, N-terminal] ; IPR022414[ATP:guanido phosphotransferase, catalytic domain] -- -- Q9WTI7 Unconventional myosin-Ic Myo1c 9763.4 10105.3 9720.8 10472.3 10285 10706 0.940444899295369 0.0221978077340867 -0.0885846762234625 Nonsignificant None 4 Molecular Function:motor activity (GO:0003774),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Cellular Component:myosin complex (GO:0016459) myosin I -- -- Myosin class I heavy chain Z Cytoskeleton ; IPR000048 [IQ motif, EF-hand binding site] ; IPR001609[Myosin head, motor domain] ; IPR010926[Class I myosin tail homology domain] -- -- Q3U9M7 Uncharacterized protein Lcp1 10029.9 12382.1 9783.7 8780 9627.6 8774.1 1.18446234047171 0.128842953331733 0.244232329368848 Nonsignificant None 2 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:protein binding (GO:0005515) plastin-2 -- -- Ca2+-binding actin-bundling protein (fimbrin/plastin), EF-Hand protein superfamily Z Cytoskeleton ; IPR001715 [Calponin homology domain] ; IPR002048[EF-hand domain] -- -- E9Q559 Calcium-transporting ATPase Atp2a3 6421.2 6060.5 7353.2 8927.1 8592.6 8683.3 0.756970575888257 0.00594439818322224 -0.40169087241099 Nonsignificant None 2 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:metal ion binding (GO:0046872) Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum 3.6.3.8 ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04972 Pancreatic secretion ko05010 Alzheimer's disease Ca2+ transporting ATPase P Inorganic ion transport and metabolism ; IPR004014 [Cation-transporting P-type ATPase, N-terminal] ; IPR006068[Cation-transporting P-type ATPase, C-terminal] ; IPR008250[P-type ATPase, A domain] ; IPR023214[HAD-like domain] -- -- Q07417 Short-chain specific acyl-CoA dehydrogenase, mitochondrial Acads 6967.6 6677.2 8898.7 9479.3 8852.4 9738.4 0.803114345869805 0.0687728679826212 -0.316322684386404 Nonsignificant None 4 Molecular Function:acyl-CoA dehydrogenase activity (GO:0003995),Biological Process:metabolic process (GO:0008152),Molecular Function:flavin adenine dinucleotide binding (GO:0050660),Biological Process:oxidation-reduction process (GO:0055114) butyryl-CoA dehydrogenase 1.3.8.1 ko00071 Fatty acid degradation ko00280 Valine, leucine and isoleucine degradation ko00650 Butanoate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01212 Fatty acid metabolism Short-chain acyl-CoA dehydrogenase I Lipid transport and metabolism ; IPR006091 [Acyl-CoA oxidase/dehydrogenase, central domain] ; IPR009075[Acyl-CoA dehydrogenase/oxidase C-terminal] ; IPR013786[Acyl-CoA dehydrogenase/oxidase, N-terminal] -- -- B2MWM9 Calreticulin Calr 19799.2 18596.8 19316.8 17716 18425.1 18513.6 1.05595310192902 0.0772304878848351 0.0785457616690064 Nonsignificant None 4 Molecular Function:calcium ion binding (GO:0005509),Cellular Component:endoplasmic reticulum (GO:0005783),Biological Process:protein folding (GO:0006457),Molecular Function:unfolded protein binding (GO:0051082) calreticulin -- ko04141 Protein processing in endoplasmic reticulum ko04145 Phagosome ko04612 Antigen processing and presentation ko05142 Chagas disease (American trypanosomiasis) ko05166 HTLV-I infection Calreticulin O Posttranslational modification, protein turnover, chaperones ; IPR001580 [Calreticulin/calnexin] -- -- Q7TPT7 Valine--tRNA ligase Vars 12139.3 12551.5 12574.1 11055.6 11477.7 11149.2 1.10635790098716 0.00331543257588339 0.145818165367678 Nonsignificant None 4 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation for protein translation (GO:0006418) valyl-tRNA synthetase 6.1.1.9 ko00970 Aminoacyl-tRNA biosynthesis Valyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR002300 [Aminoacyl-tRNA synthetase, class Ia] ; IPR004046[Glutathione S-transferase, C-terminal] ; IPR013155[Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding] -- -- G3UVV4 Hexokinase Hk1 11058.8 10760 10769.2 12983.4 12978.8 12549.4 0.846186603516862 0.00034508834213215 -0.240952249175108 Nonsignificant None 2 Molecular Function:ATP binding (GO:0005524),Biological Process:carbohydrate metabolic process (GO:0005975) hexokinase 2.7.1.1 ko00010 Glycolysis / Gluconeogenesis ko00051 Fructose and mannose metabolism ko00052 Galactose metabolism ko00500 Starch and sucrose metabolism ko00520 Amino sugar and nucleotide sugar metabolism ko00524 Neomycin, kanamycin and gentamicin biosynthesis ko01100 Metabolic pathways ko01200 Carbon metabolism ko04066 HIF-1 signaling pathway ko04910 Insulin signaling pathway ko04930 Type II diabetes mellitus ko04973 Carbohydrate digestion and absorption ko05230 Central carbon metabolism in cancer Hexokinase G Carbohydrate transport and metabolism ; IPR022672 [Hexokinase, N-terminal] ; IPR022673[Hexokinase, C-terminal] -- -- G5E8R0 Tropomyosin alpha-1 chain Tpm1 102.2 89.6 86.5 93 94.4 101.5 0.963309103496019 0.553819996503673 -0.0539292952330081 Nonsignificant None -- -- tropomyosin 1 -- ko04260 Cardiac muscle contraction ko04261 Adrenergic signaling in cardiomyocytes ko05206 MicroRNAs in cancer ko05410 Hypertrophic cardiomyopathy (HCM) ko05414 Dilated cardiomyopathy (DCM) Actin filament-coating protein tropomyosin Z Cytoskeleton ; IPR000533 [Tropomyosin] -- -- E9Q7G0 Nuclear mitotic apparatus protein 1 Numa1 4714.2 4659.1 5502.2 5380.4 5239.1 5276.3 0.935813233684369 0.337563228847202 -0.0957074643556089 Nonsignificant None -- -- nuclear mitotic apparatus protein 1 -- -- -- -- -- -- -- -- Q9DCV7 Keratin, type II cytoskeletal 7 Krt7 14283 13762.9 13237.4 11775.1 11010.2 12655.7 1.16484580006207 0.0258598573440194 0.220138986459183 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) type II keratin, basic -- -- -- -- -- IPR001664 [Intermediate filament protein] ; IPR032444[Keratin type II head] -- -- Q7TPV4 Myb-binding protein 1A Mybbp1a 9410 9704.8 9409.8 7623.7 7772.8 7437.5 1.2492160812823 0.000162746858245026 0.321023046546766 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Molecular Function:DNA-directed DNA polymerase activity (GO:0003887) DNA polymerase phi 2.7.7.7 -- Predicted regulator of rRNA gene transcription (MYB-binding protein) K Transcription ; IPR007015 [DNA polymerase V] -- -- O08553 Dihydropyrimidinase-related protein 2 Dpysl2 6157.3 5901.4 6861.7 7174.3 7144.8 7276.7 0.876114800100019 0.087175284686976 -0.190808171769178 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) dihydropyrimidinase-like 2 -- ko04360 Axon guidance Dihydroorotase and related enzymes F Nucleotide transport and metabolism ; IPR006680 [Amidohydrolase-related] -- -- Q3TCI7 L-lactate dehydrogenase Ldha 1846.9 1632.8 992.4 891.9 947.4 1037.6 1.55448573116897 0.110484877587484 0.636437374050319 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) L-lactate dehydrogenase 1.1.1.27 ko00010 Glycolysis / Gluconeogenesis ko00270 Cysteine and methionine metabolism ko00620 Pyruvate metabolism ko00640 Propanoate metabolism ko01100 Metabolic pathways ko04922 Glucagon signaling pathway Lactate dehydrogenase C Energy production and conversion ; IPR001236 [Lactate/malate dehydrogenase, N-terminal] ; IPR022383[Lactate/malate dehydrogenase, C-terminal] -- -- Q91YQ5 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 Rpn1 13260.7 14650.7 16445.1 14700.8 14565.1 13669.2 1.03310578058512 0.65303439656052 0.0469879805460629 Nonsignificant None 4 Molecular Function:dolichyl-diphosphooligosaccharide-protein glycotransferase activity (GO:0004579),Cellular Component:endoplasmic reticulum (GO:0005783),Biological Process:protein glycosylation (GO:0006486),Cellular Component:integral component of membrane (GO:0016021) oligosaccharyltransferase complex subunit alpha (ribophorin I) -- ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways ko04141 Protein processing in endoplasmic reticulum Oligosaccharyltransferase, alpha subunit (ribophorin I) O Posttranslational modification, protein turnover, chaperones ; IPR007676 [Ribophorin I] -- -- Q3UQ44 Ras GTPase-activating-like protein IQGAP2 Iqgap2 11007.6 10658 11386.9 11077.2 11232.8 10644.6 1.00297075370358 0.9110476855219 0.00427953805181106 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Biological Process:regulation of GTPase activity (GO:0043087) Ras GTPase-activating-like protein IQGAP2/3 -- ko04810 Regulation of actin cytoskeleton Ras GTPase-activating protein family - IQGAP T Signal transduction mechanisms ; IPR000048 [IQ motif, EF-hand binding site] ; IPR000593[RasGAP protein, C-terminal] ; IPR001715[Calponin homology domain] ; IPR001936[Ras GTPase-activating protein] -- -- Q60597 2-oxoglutarate dehydrogenase complex component E1 Ogdh 15792.8 15731.5 13249.5 15324.8 15012.6 16540.1 0.955123460082129 0.505007108428189 -0.0662408656802598 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) 2-oxoglutarate dehydrogenase E1 component 1.2.4.2 ko00020 Citrate cycle (TCA cycle) ko00310 Lysine degradation ko00380 Tryptophan metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism 2-oxoglutarate dehydrogenase, E1 subunit G Carbohydrate transport and metabolism ; IPR001017 [Dehydrogenase, E1 component] ; IPR005475[Transketolase-like, pyrimidine-binding domain] ; IPR031717[Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal] ; IPR032106[2-oxoglutarate dehydrogenase E1 component, N-terminal domain] -- -- P21550 Beta-enolase Eno3 3106.1 2834.8 3174.8 6788.7 7199.5 9491.1 0.388244112899448 0.0279363595512196 -1.36496404627006 Significant down -- -- enolase 4.2.1.11 ko00010 Glycolysis / Gluconeogenesis ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids ko03018 RNA degradation ko04066 HIF-1 signaling pathway Enolase G Carbohydrate transport and metabolism ; IPR020810 [Enolase, C-terminal TIM barrel domain] ; IPR020811[Enolase, N-terminal] -- -- P68040 Receptor of activated protein C kinase 1 Rack1 13424.4 13378.4 12815.1 12133.1 12131.7 12783 1.06937254033978 0.0427482800550069 0.0967645363804407 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) guanine nucleotide-binding protein subunit beta-2-like 1 protein -- ko05162 Measles G protein beta subunit-like protein T Signal transduction mechanisms ; IPR001680 [WD40 repeat] -- -- Q9ERD7 Tubulin beta-3 chain Tubb3 1606.7 1668.3 2017 2036.1 1988.7 1887.2 0.895128552097429 0.200776163680807 -0.159833207867474 Nonsignificant None 1 Molecular Function:GTPase activity (GO:0003924) tubulin beta -- ko04145 Phagosome ko04540 Gap junction Beta tubulin Z Cytoskeleton ; IPR003008 [Tubulin/FtsZ, GTPase domain] ; IPR018316[Tubulin/FtsZ, 2-layer sandwich domain] -- -- E9PVA8 eIF-2-alpha kinase activator GCN1 Gcn1 2796.1 2739.4 2626.4 2320 2373.6 2455.7 1.14163624410781 0.00605801755238346 0.191103042628286 Nonsignificant None -- -- -- -- -- Protein containing adaptin N-terminal region J Translation, ribosomal structure and biogenesis ; -- -- -- Q8VDC3 Cytoplasmic aconitate hydratase aco1 9474.4 9193.5 9122.9 9719.5 9743.1 10048.3 0.94171306195338 0.0190622582800461 -0.086640554324786 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) aconitate hydratase 4.2.1.3 ko00020 Citrate cycle (TCA cycle) ko00630 Glyoxylate and dicarboxylate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01210 2-Oxocarboxylic acid metabolism ko01230 Biosynthesis of amino acids RNA-binding translational regulator IRP (aconitase superfamily) AJ RNA processing and modification ; Translation, ribosomal structure and biogenesis ; IPR000573 [Aconitase A/isopropylmalate dehydratase small subunit, swivel domain] ; IPR001030[Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain] -- -- Q5SVG5 AP complex subunit beta Ap1b1 5934.4 5721.9 6466.1 6980.6 6941.1 7169 0.859260242666199 0.013046124675761 -0.218832950785389 Nonsignificant None 4 Biological Process:intracellular protein transport (GO:0006886),Biological Process:vesicle-mediated transport (GO:0016192),Cellular Component:membrane coat (GO:0030117),Cellular Component:clathrin adaptor complex (GO:0030131) AP-1 complex subunit beta-1 -- ko04142 Lysosome Vesicle coat complex AP-1/AP-2/AP-4, beta subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR002553 [Clathrin/coatomer adaptor, adaptin-like, N-terminal] ; IPR008152[Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain] ; IPR015151[Beta-adaptin appendage, C-terminal subdomain] ; IPR032682[Condensin complex subunit 1, C-terminal] -- -- Q6A0F1 T-complex protein 1 subunit theta (Fragment) Cct8 15674.6 15412.7 15997.3 14309.4 14352.2 14789 1.08363520871979 0.00605087535723487 0.115879174455647 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) T-complex protein 1 subunit theta -- -- Chaperonin complex component, TCP-1 theta subunit (CCT8) O Posttranslational modification, protein turnover, chaperones ; IPR002423 [Chaperonin Cpn60/TCP-1 family] -- -- Q8BFR5 Elongation factor Tu, mitochondrial Tufm 9098.9 9222.1 10112.3 10441.8 10293.5 10130.9 0.921179153896495 0.0707998102764349 -0.1184463312929 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) elongation factor Tu -- -- Mitochondrial translation elongation factor Tu J Translation, ribosomal structure and biogenesis ; IPR004160 [Translation elongation factor EFTu/EF1A, C-terminal] ; IPR004161[Translation elongation factor EFTu-like, domain 2] -- -- Q02248 Catenin beta-1 Ctnnb1 9323.2 9084.5 9580.1 9638.8 9674.7 9377 0.975507572192886 0.242877146161794 -0.0357750233624137 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) catenin beta 1 -- ko04015 Rap1 signaling pathway ko04310 Wnt signaling pathway ko04390 Hippo signaling pathway ko04510 Focal adhesion ko04520 Adherens junction ko04550 Signaling pathways regulating pluripotency of stem cells ko04670 Leukocyte transendothelial migration ko04916 Melanogenesis ko04919 Thyroid hormone signaling pathway ko05100 Bacterial invasion of epithelial cells ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05210 Colorectal cancer ko05213 Endometrial cancer ko05215 Prostate cancer ko05216 Thyroid cancer ko05217 Basal cell carcinoma ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05418 Fluid shear stress and atherosclerosis Armadillo/beta-Catenin/plakoglobin TZ Signal transduction mechanisms ; Cytoskeleton ; IPR000225 [Armadillo] -- -- P26041 Moesin Msn 10953 11574.1 9654.8 9077.9 9123.2 9006.6 1.18282324489023 0.0987495409450014 0.24223450075074 Nonsignificant None 3 Cellular Component:cytoplasm (GO:0005737),Molecular Function:cytoskeletal protein binding (GO:0008092),Cellular Component:extrinsic component of membrane (GO:0019898) moesin -- ko04530 Tight junction ko04670 Leukocyte transendothelial migration ko04810 Regulation of actin cytoskeleton ko05162 Measles ko05205 Proteoglycans in cancer Radixin, moesin and related proteins of the ERM family R General function prediction only ; IPR011259 [Ezrin/radixin/moesin, C-terminal] ; IPR018979[FERM, N-terminal] ; IPR018980[FERM, C-terminal PH-like domain] ; IPR019748[FERM central domain] -- -- P60843 Eukaryotic initiation factor 4A-I Eif4a1 6808.8 7189.2 5492.6 4781.5 4943.8 4972.1 1.32612570930913 0.0878731885604842 0.4072175413635 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) translation initiation factor 4A -- ko03013 RNA transport Translation initiation factor 4F, helicase subunit (eIF-4A) and related helicases J Translation, ribosomal structure and biogenesis ; IPR001650 [Helicase, C-terminal] ; IPR011545[DEAD/DEAH box helicase domain] -- -- Q8CD23 Nucleolin Ncl 2653.6 2829 674.5 667.6 735.5 669.2 2.97114317425083 0.187375685310199 1.57101812782724 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) nucleolin -- Polyadenylate-binding protein (RRM superfamily) AJ RNA processing and modification ; Translation, ribosomal structure and biogenesis ; IPR000504 [RNA recognition motif domain] -- -- Q9DCD0 6-phosphogluconate dehydrogenase, decarboxylating Pgd 14429.1 14512.8 14873.2 14140.1 15218.9 13772.1 1.01585862637401 0.642627655437927 0.0226996410661637 Nonsignificant None 3 Molecular Function:phosphogluconate dehydrogenase (decarboxylating) activity (GO:0004616),Biological Process:pentose-phosphate shunt (GO:0006098),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00030 Pentose phosphate pathway ko00480 Glutathione metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism 6-phosphogluconate dehydrogenase G Carbohydrate transport and metabolism ; IPR006114 [6-phosphogluconate dehydrogenase, C-terminal] ; IPR006115[6-phosphogluconate dehydrogenase, NADP-binding] -- -- B1ARU4 Microtubule-actin cross-linking factor 1 Macf1 939.1 815 788.3 794.2 849.7 781.5 1.04823946565515 0.486760793000713 0.0679683318075413 Nonsignificant None 4 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:protein binding (GO:0005515),Cellular Component:cytoskeleton (GO:0005856),Molecular Function:microtubule binding (GO:0008017) microtuble-actin crosslinking factor 1 -- -- Dystonin, GAS (Growth-arrest-specific protein), and related proteins Z Cytoskeleton ; IPR001101 [Plectin repeat] ; IPR001715[Calponin homology domain] ; IPR002017[Spectrin repeat] ; IPR002048[EF-hand domain] ; IPR003108[Gas2-related domain] -- -- Q3TW74 C-1-tetrahydrofolate synthase, cytoplasmic Mthfd1 11815.9 11630 12549.9 12780.1 12587.3 12898.7 0.940670724218042 0.0623564881735177 -0.0882382897562609 Nonsignificant None 6 Molecular Function:catalytic activity (GO:0003824),Molecular Function:formate-tetrahydrofolate ligase activity (GO:0004329),Molecular Function:methylenetetrahydrofolate dehydrogenase (NADP+) activity (GO:0004488),Molecular Function:ATP binding (GO:0005524),Biological Process:folic acid-containing compound biosynthetic process (GO:0009396),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00670 One carbon pool by folate ko01100 Metabolic pathways C1-tetrahydrofolate synthase H Coenzyme transport and metabolism ; IPR000559 [Formate-tetrahydrofolate ligase, FTHFS] ; IPR020630[Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain] ; IPR020631[Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain] -- -- Q542G9 Annexin Anxa2 30064.9 29757.7 24802 22977.2 23678.2 25314.3 1.17583649785952 0.0836923563848898 0.233687464828601 Nonsignificant None 2 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:calcium-dependent phospholipid binding (GO:0005544) annexin A2 -- -- Annexin U Intracellular trafficking, secretion, and vesicular transport ; IPR018502 [Annexin repeat] -- -- E9Q586 Dynactin subunit 1 Dctn1 75.3 73.8 64.3 66.4 71.4 63.4 1.06063618290258 0.383641078134416 0.0849298710188979 Nonsignificant None -- -- dynactin 1 -- ko04962 Vasopressin-regulated water reabsorption ko05016 Huntington's disease Microtubule-associated protein dynactin DCTN1/Glued DZ Cell cycle control, cell division, chromosome partitioning ; Cytoskeleton ; IPR000938 [CAP Gly-rich domain] ; IPR022157[Dynein associated protein] -- -- Q8BFZ3 Beta-actin-like protein 2 Actbl2 40.9 48.5 45.6 61.7 81 42.9 0.727370689655172 0.207182909964515 -0.459237303189379 Nonsignificant None -- -- -- -- -- Actin and related proteins Z Cytoskeleton ; IPR004000 [Actin family] -- -- Q99PV0 Pre-mRNA-processing-splicing factor 8 Prpf8 8295.2 8152.7 8784.7 7419 7691.7 7295.6 1.12613863065299 0.0136999702691829 0.171384437937414 Nonsignificant None 4 Molecular Function:RNA binding (GO:0003723),Molecular Function:protein binding (GO:0005515),Molecular Function:U6 snRNA binding (GO:0017070),Molecular Function:U5 snRNA binding (GO:0030623) pre-mRNA-processing factor 8 -- ko03040 Spliceosome U5 snRNP spliceosome subunit A RNA processing and modification ; IPR000555 [JAB1/MPN/MOV34 metalloenzyme domain] ; IPR012591[PRO8NT domain] ; IPR012592[PROCN domain] ; IPR012984[PROCT domain] ; IPR019580[Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding] ; IPR019581[Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding] ; IPR019582[RNA recognition motif, spliceosomal PrP8] ; IPR021983[PRP8 domain IV core] -- -- Q76MZ3 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Ppp2r1a 6244.9 6259.5 5859.1 6118.6 5955.4 5904.5 1.02141446728036 0.429452481272747 0.0305683985920045 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) serine/threonine-protein phosphatase 2A regulatory subunit A -- ko03015 mRNA surveillance pathway ko04071 Sphingolipid signaling pathway ko04114 Oocyte meiosis ko04151 PI3K-Akt signaling pathway ko04152 AMPK signaling pathway ko04261 Adrenergic signaling in cardiomyocytes ko04350 TGF-beta signaling pathway ko04390 Hippo signaling pathway ko04530 Tight junction ko04728 Dopaminergic synapse ko04730 Long-term depression ko05142 Chagas disease (American trypanosomiasis) ko05160 Hepatitis C ko05165 Human papillomavirus infection Protein phosphatase 2A regulatory subunit A and related proteins T Signal transduction mechanisms ; IPR000357 [HEAT repeat] -- -- Q9CQ19 Myosin regulatory light polypeptide 9 Myl9 9149.6 10100.9 10176.6 10900.3 10616.2 10701.7 0.913368841213972 0.0525266624708774 -0.130730520621975 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) myosin regulatory light chain 9 -- ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04270 Vascular smooth muscle contraction ko04510 Focal adhesion ko04530 Tight junction ko04670 Leukocyte transendothelial migration ko04810 Regulation of actin cytoskeleton ko04921 Oxytocin signaling pathway Myosin regulatory light chain, EF-Hand protein superfamily Z Cytoskeleton ; IPR002048 [EF-hand domain] -- -- P97807 Fumarate hydratase, mitochondrial Fh 8650.8 8465.1 10438.2 10611.5 10535.8 10826 0.86178467658953 0.14151328263134 -0.214600648800214 Nonsignificant None 2 Biological Process:tricarboxylic acid cycle (GO:0006099),Molecular Function:lyase activity (GO:0016829) fumarate hydratase, class II 4.2.1.2 ko00020 Citrate cycle (TCA cycle) ko00620 Pyruvate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko05200 Pathways in cancer ko05211 Renal cell carcinoma Fumarase C Energy production and conversion ; IPR018951 [Fumarase C, C-terminal] ; IPR022761[Fumarate lyase, N-terminal] -- -- P08071 Lactotransferrin Ltf 8857.9 14235.8 9492.7 3880.7 4061.1 3755.5 2.78580527130192 0.0541996809263433 1.47809441660912 Nonsignificant None -- -- lactotransferrin 3.4.21.- -- -- -- -- IPR001156 [Transferrin-like domain] -- -- E9Q456 Tropomyosin alpha-1 chain Tpm1 1048.5 975 1061.4 1120.6 1061 1111.1 0.93689069760379 0.101157222857294 -0.0940473492687151 Nonsignificant None -- -- tropomyosin 1 -- ko04260 Cardiac muscle contraction ko04261 Adrenergic signaling in cardiomyocytes ko05206 MicroRNAs in cancer ko05410 Hypertrophic cardiomyopathy (HCM) ko05414 Dilated cardiomyopathy (DCM) Actin filament-coating protein tropomyosin Z Cytoskeleton ; IPR000533 [Tropomyosin] -- -- Q9JKR6 Hypoxia up-regulated protein 1 Hyou1 11584.2 11580.4 10193.6 8865.2 9257.9 8705.2 1.24339596619987 0.0114077137917148 0.314285803633418 Nonsignificant None -- -- hypoxia up-regulated 1 -- ko04141 Protein processing in endoplasmic reticulum Molecular chaperones GRP170/SIL1, HSP70 superfamily O Posttranslational modification, protein turnover, chaperones ; IPR013126 [Heat shock protein 70 family] -- -- Q8K2B3 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Sdha 10858 10880.2 11980.4 13939.6 13609.8 14645 0.799125002369983 0.00416771366564511 -0.323506901879595 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) succinate dehydrogenase (ubiquinone) flavoprotein subunit 1.3.5.1 ko00020 Citrate cycle (TCA cycle) ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko01200 Carbon metabolism ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Succinate dehydrogenase, flavoprotein subunit C Energy production and conversion ; IPR003953 [FAD-dependent oxidoreductase 2, FAD binding domain] ; IPR015939[Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal] -- -- Q9D312 Keratin, type I cytoskeletal 20 Krt20 13655.5 12107.9 14776 13619.8 13769.1 12079.6 1.02713303013796 0.724356395461098 0.0386230458151216 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) type I keratin, acidic -- -- -- -- -- IPR001664 [Intermediate filament protein] -- -- Q3THB4 L-lactate dehydrogenase Ldha 763.4 670.5 692.7 697.9 757.2 709.5 0.982444793495334 0.723573838794883 -0.025551754577942 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) L-lactate dehydrogenase 1.1.1.27 ko00010 Glycolysis / Gluconeogenesis ko00270 Cysteine and methionine metabolism ko00620 Pyruvate metabolism ko00640 Propanoate metabolism ko01100 Metabolic pathways ko04922 Glucagon signaling pathway Lactate dehydrogenase C Energy production and conversion ; IPR001236 [Lactate/malate dehydrogenase, N-terminal] ; IPR022383[Lactate/malate dehydrogenase, C-terminal] -- -- Q60932 Voltage-dependent anion-selective channel protein 1 Vdac1 11550.8 11341.2 11631.2 13110.6 12482 13143.1 0.891250190392842 0.00375281851279893 -0.166097615135853 Nonsignificant None 2 Cellular Component:mitochondrial outer membrane (GO:0005741),Biological Process:transmembrane transport (GO:0055085) voltage-dependent anion channel protein 1 -- ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04217 Necroptosis ko04218 Cellular senescence ko04621 NOD-like receptor signaling pathway ko04979 Cholesterol metabolism ko05012 Parkinson's disease ko05016 Huntington's disease ko05164 Influenza A ko05166 HTLV-I infection Porin/voltage-dependent anion-selective channel protein P Inorganic ion transport and metabolism ; IPR027246 [Eukaryotic porin/Tom40] -- -- A2A863 Integrin beta-4 Itgb4 9952.3 9895 10110.1 10167.2 10401.3 10334.1 0.969413576851139 0.0292436158292161 -0.0448158069790407 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Biological Process:cell communication (GO:0007154),Cellular Component:integral component of membrane (GO:0016021) integrin beta 4 -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04810 Regulation of actin cytoskeleton ko05165 Human papillomavirus infection ko05410 Hypertrophic cardiomyopathy (HCM) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05414 Dilated cardiomyopathy (DCM) Integrin beta subunit (N-terminal portion of extracellular region) TW Signal transduction mechanisms ; Extracellular structures ; IPR002369 [Integrin beta subunit, VWA domain] ; IPR003644[Na-Ca exchanger/integrin-beta4] ; IPR003961[Fibronectin type III] ; IPR012896[Integrin beta subunit, tail] ; IPR033760[Integrin beta N-terminal] -- -- Q8BHN3 Neutral alpha-glucosidase AB Ganab 9189.5 9246.3 9617.5 9729.6 9714.6 9610.6 0.965530652422319 0.0746722672332804 -0.0506060341622802 Nonsignificant None 1 Biological Process:carbohydrate metabolic process (GO:0005975) alpha 1,3-glucosidase 3.2.1.84 ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways ko04141 Protein processing in endoplasmic reticulum Glucosidase II catalytic (alpha) subunit and related enzymes, glycosyl hydrolase family 31 GMO Carbohydrate transport and metabolism ; Cell wall/membrane/envelope biogenesis ; Posttranslational modification, protein turnover, chaperones ; IPR000322 [Glycoside hydrolase family 31] ; IPR025887[Glycoside hydrolase family 31, N-terminal domain] -- -- Q91ZJ5 UTP--glucose-1-phosphate uridylyltransferase Ugp2 8024.5 7709 9555.4 10089.7 10005.5 9463.4 0.855551345462911 0.0776511484648879 -0.225073654992244 Nonsignificant None 2 Biological Process:metabolic process (GO:0008152),Molecular Function:uridylyltransferase activity (GO:0070569) UTP--glucose-1-phosphate uridylyltransferase 2.7.7.9 ko00040 Pentose and glucuronate interconversions ko00052 Galactose metabolism ko00500 Starch and sucrose metabolism ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways UDP-glucose pyrophosphorylase G Carbohydrate transport and metabolism ; IPR002618 [UDPGP family] -- -- Q9D0K2 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial Oxct1 7474.8 7132.9 7267.8 9074.7 9159.1 9107.2 0.800098752788852 0.0000586885062052139 -0.32175001817968 Nonsignificant None 2 Biological Process:metabolic process (GO:0008152),Molecular Function:CoA-transferase activity (GO:0008410) 3-oxoacid CoA-transferase 2.8.3.5 ko00072 Synthesis and degradation of ketone bodies ko00280 Valine, leucine and isoleucine degradation ko00650 Butanoate metabolism Succinyl-CoA:alpha-ketoacid-CoA transferase C Energy production and conversion ; IPR004165 [Coenzyme A transferase family I] -- -- Q91VI7 Ribonuclease inhibitor Rnh1 8886.6 9454.7 9558.7 8894.8 9263.6 9158.4 1.02134949920928 0.456229066500588 0.0304766316374865 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) ribonuclease inhibitor -- -- LRR-containing protein S Function unknown ; IPR001611 [Leucine-rich repeat] -- -- O88844 Isocitrate dehydrogenase [NADP] cytoplasmic Idh1 13988.1 14116.5 16712.2 15557.8 15273.3 16057.4 0.955816458193374 0.493092058251529 -0.0651944853386228 Nonsignificant None 1 Biological Process:oxidation-reduction process (GO:0055114) isocitrate dehydrogenase 1.1.1.42 ko00020 Citrate cycle (TCA cycle) ko00480 Glutathione metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01210 2-Oxocarboxylic acid metabolism ko01230 Biosynthesis of amino acids ko04146 Peroxisome NADP-dependent isocitrate dehydrogenase C Energy production and conversion ; IPR024084 [Isopropylmalate dehydrogenase-like domain] -- -- B9EKE9 RNA helicase Ddx3x 14781.9 15353.8 14739.4 13004 12586 12594.5 1.17521769304299 0.000762917104121526 0.232928021116796 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase DDX3X 3.6.4.13 ko04622 RIG-I-like receptor signaling pathway ko05161 Hepatitis B ko05203 Viral carcinogenesis ATP-dependent RNA helicase A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR011545[DEAD/DEAH box helicase domain] -- -- P80315 T-complex protein 1 subunit delta Cct4 10117.5 9282.4 9043.2 8870.1 8764.8 8865.1 1.07332452830189 0.183748343738606 0.102086352500127 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) T-complex protein 1 subunit delta -- -- Chaperonin complex component, TCP-1 delta subunit (CCT4) O Posttranslational modification, protein turnover, chaperones ; IPR002423 [Chaperonin Cpn60/TCP-1 family] -- -- E9Q3M3 Dynactin subunit 1 Dctn1 86.7 91.3 95.9 95 97 92.7 0.962065331928346 0.286822967545178 -0.0557932270368875 Nonsignificant None -- -- dynactin 1 -- ko04962 Vasopressin-regulated water reabsorption ko05016 Huntington's disease Microtubule-associated protein dynactin DCTN1/Glued DZ Cell cycle control, cell division, chromosome partitioning ; Cytoskeleton ; IPR000938 [CAP Gly-rich domain] ; IPR022157[Dynein associated protein] -- -- Q3THB3 Uncharacterized protein Hnrnpm 19116.3 18506.7 17208.4 16157.4 16513 16542.1 1.11417627635255 0.0313308590666838 0.155977502786449 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) heterogeneous nuclear ribonucleoprotein M -- ko03040 Spliceosome RNA-binding protein hnRNP-M A RNA processing and modification ; IPR000504 [RNA recognition motif domain] ; IPR024666[Heterogeneous nuclear ribonucleoprotein M, PY nuclear localisation signal] -- -- Q6XMP4 Alanine--tRNA ligase Aars 11894.8 11287.8 11612.7 9827.7 9809.4 9882 1.17873851167549 0.00898154260198045 0.237243710048143 Nonsignificant None 6 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:alanine-tRNA ligase activity (GO:0004813),Molecular Function:ATP binding (GO:0005524),Biological Process:alanyl-tRNA aminoacylation (GO:0006419),Biological Process:tRNA aminoacylation (GO:0043039) alanyl-tRNA synthetase 6.1.1.7 ko00970 Aminoacyl-tRNA biosynthesis Alanyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR003156 [DHHA1 domain] ; IPR012947[Threonyl/alanyl tRNA synthetase, SAD] ; IPR018164[Alanyl-tRNA synthetase, class IIc, N-terminal] -- -- Q60997 Deleted in malignant brain tumors 1 protein Dmbt1 6687.3 6148.6 8326.7 4118.4 4377.6 4135.3 1.67540949862643 0.0471249936515458 0.744513757918569 Significant up 2 Molecular Function:scavenger receptor activity (GO:0005044),Cellular Component:membrane (GO:0016020) deleted in malignant brain tumors 1 protein -- ko04970 Salivary secretion -- -- -- IPR000859 [CUB domain] ; IPR001190[SRCR domain] ; IPR001507[Zona pellucida domain] -- -- Q7M739 Nucleoprotein TPR Tpr 8803.1 8798.5 9219.9 8826.6 9001.4 8846.9 1.00549580317077 0.761249400020819 0.00790706000492373 Nonsignificant None 1 Biological Process:protein import into nucleus (GO:0006606) nucleoprotein TPR -- ko03013 RNA transport ko05200 Pathways in cancer ko05216 Thyroid cancer Uncharacterized conserved coiled-coil protein S Function unknown ; IPR012929 [Nucleoprotein TPR/MLP1] -- -- A0A5F8MPH8 Tenascin XB Tnxb 7504.5 7698.8 9145.2 9669.2 9362.8 9768 0.845434027777778 0.0492870138267871 -0.242235914481874 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) tenascin -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko05165 Human papillomavirus infection ko05206 MicroRNAs in cancer Teneurin-1 and related extracellular matrix proteins, contain EGF-like repeats TW Signal transduction mechanisms ; Extracellular structures ; IPR002181 [Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain] ; IPR003961[Fibronectin type III] -- -- Q3UMM1 Tubulin beta chain Tubb6 2135.6 2309.7 2219.2 1819.7 1762 1583.8 1.29019456006195 0.00455357634768743 0.367588639037301 Nonsignificant None 1 Molecular Function:GTPase activity (GO:0003924) tubulin beta -- ko04145 Phagosome ko04540 Gap junction Beta tubulin Z Cytoskeleton ; IPR003008 [Tubulin/FtsZ, GTPase domain] ; IPR018316[Tubulin/FtsZ, 2-layer sandwich domain] -- -- Q8CE30 Nucleolin Ncl 103.8 100.2 97.8 80.2 85.2 76.9 1.2455633512175 0.00263623307387087 0.316798401075337 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) nucleolin -- Polyadenylate-binding protein (RRM superfamily) AJ RNA processing and modification ; Translation, ribosomal structure and biogenesis ; IPR000504 [RNA recognition motif domain] -- -- E9Q1U2 Synaptopodin-2 Synpo2 6845.2 7172.5 7095 7329.6 6704.9 6493.1 1.02850308852472 0.509777776176144 0.0405461261842898 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR001478 [PDZ domain] -- -- Q9R112 Sulfide:quinone oxidoreductase, mitochondrial Sqor 9423.4 8709 9946.1 11190.1 10872.7 10245.2 0.869088151541414 0.0359056007263531 -0.202425577983807 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) Sulfide:quinone oxidoreductase/flavo-binding protein C Energy production and conversion ; IPR023753 [FAD/NAD(P)-binding domain] -- -- P62631 Elongation factor 1-alpha 2 Eef1a2 41.7 30.9 39.3 44 35.9 53.2 0.840721262208865 0.302386046018521 -0.250300534935498 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) elongation factor 1-alpha -- ko03013 RNA transport ko05134 Legionellosis Translation elongation factor EF-1 alpha/Tu J Translation, ribosomal structure and biogenesis ; IPR004160 [Translation elongation factor EFTu/EF1A, C-terminal] ; IPR004161[Translation elongation factor EFTu-like, domain 2] -- -- Q6ZQ38 Cullin-associated NEDD8-dissociated protein 1 Cand1 10823.6 11127.4 11170.4 10120.6 9768 11069.8 1.06986795183214 0.148691294097587 0.0974327433619539 Nonsignificant None -- -- cullin-associated NEDD8-dissociated protein 1 -- -- TATA-binding protein-interacting protein R General function prediction only ; IPR013932 [TATA-binding protein interacting (TIP20)] -- -- Q4FJV4 Annexin Anxa1 13451.8 16251.1 12739.2 10021.3 9926.8 10021.4 1.41617644605349 0.0603712232096593 0.502001026711585 Nonsignificant None 2 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:calcium-dependent phospholipid binding (GO:0005544) annexin A1 -- -- Annexin U Intracellular trafficking, secretion, and vesicular transport ; IPR018502 [Annexin repeat] -- -- P80313 T-complex protein 1 subunit eta Cct7 15022.5 14831.5 13687.1 12827.1 12980.3 13122 1.11846316665554 0.0225126538897747 0.161517746197315 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) T-complex protein 1 subunit eta -- -- Chaperonin complex component, TCP-1 eta subunit (CCT7) O Posttranslational modification, protein turnover, chaperones ; IPR002423 [Chaperonin Cpn60/TCP-1 family] -- -- E9QAI5 CAD protein Cad 6084 6046.6 5170.6 4909.7 4908.8 5036.3 1.16468750841479 0.109102688946833 0.219942924377499 Nonsignificant None 5 Molecular Function:ATP binding (GO:0005524),Biological Process:cellular amino acid metabolic process (GO:0006520),Molecular Function:amino acid binding (GO:0016597),Molecular Function:carboxyl- or carbamoyltransferase activity (GO:0016743),Molecular Function:hydrolase activity (GO:0016787) -- -- ko00240 Pyrimidine metabolism ko00250 Alanine, aspartate and glutamate metabolism ko01100 Metabolic pathways Multifunctional pyrimidine synthesis protein CAD (includes carbamoyl-phophate synthetase, aspartate transcarbamylase, and glutamine amidotransferase) R General function prediction only ; IPR002474 [Carbamoyl-phosphate synthase, small subunit N-terminal domain] ; IPR005479[Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain] ; IPR005480[Carbamoyl-phosphate synthetase, large subunit oligomerisation domain] ; IPR006131[Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain] ; IPR006132[Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding] ; IPR006680[Amidohydrolase-related] ; IPR011607[Methylglyoxal synthase-like domain] ; IPR017926[Glutamine amidotransferase] -- -- P62259 14-3-3 protein epsilon Ywhae 18364.4 17740.4 16853.1 15531.6 15477.6 16865.5 1.10617716664543 0.0549518982876914 0.14558246782514 Nonsignificant None -- -- 14-3-3 protein epsilon -- ko04110 Cell cycle ko04114 Oocyte meiosis ko04151 PI3K-Akt signaling pathway ko04390 Hippo signaling pathway ko04722 Neurotrophin signaling pathway ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis Multifunctional chaperone (14-3-3 family) O Posttranslational modification, protein turnover, chaperones ; IPR023410 [14-3-3 domain] -- -- P30999 Catenin delta-1 Ctnnd1 777.8 629 613.8 547.3 558.3 606.7 1.18005022484378 0.137234849314637 0.238848264325283 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) catenin (cadherin-associated protein), delta 1 -- ko04015 Rap1 signaling pathway ko04520 Adherens junction ko04670 Leukocyte transendothelial migration Neural adherens junction protein Plakophilin and related Armadillo repeat proteins TW Signal transduction mechanisms ; Extracellular structures ; IPR000225 [Armadillo] -- -- F7ACR9 Microtubule-actin cross-linking factor 1 (Fragment) Macf1 75.1 66 81.6 84.5 95.5 88.9 0.828188917813313 0.0498155964045693 -0.271968197085083 Nonsignificant None 3 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:protein binding (GO:0005515),Molecular Function:microtubule binding (GO:0008017) microtuble-actin crosslinking factor 1 -- -- Dystonin, GAS (Growth-arrest-specific protein), and related proteins Z Cytoskeleton ; IPR001715 [Calponin homology domain] ; IPR002017[Spectrin repeat] ; IPR002048[EF-hand domain] ; IPR003108[Gas2-related domain] -- -- D3Z6I8 Tropomyosin alpha-3 chain Tpm3 1702.7 1789 1716.1 1640.4 1665.2 1574.8 1.06708466519138 0.0454818816329941 0.0936746477705109 Nonsignificant None -- -- tropomyosin 4 -- ko04260 Cardiac muscle contraction ko04261 Adrenergic signaling in cardiomyocytes ko05410 Hypertrophic cardiomyopathy (HCM) ko05414 Dilated cardiomyopathy (DCM) Actin filament-coating protein tropomyosin Z Cytoskeleton ; IPR000533 [Tropomyosin] -- -- O88428 Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 2 Papss2 6966.3 6737.5 8936.6 8828.4 8722.8 8419.3 0.871773743285651 0.192350706086012 -0.197974342677478 Nonsignificant None 1 Molecular Function:sulfate adenylyltransferase (ATP) activity (GO:0004781) -- -- ko00230 Purine metabolism ko00450 Selenocompound metabolism ko00920 Sulfur metabolism ko01100 Metabolic pathways Bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase F Nucleotide transport and metabolism ; IPR024951 [Sulphate adenylyltransferase catalytic domain] ; IPR025980[ATP-sulfurylase PUA-like domain] -- -- Q8QZT1 Acetyl-CoA acetyltransferase, mitochondrial Acat1 12888.7 12646.2 15217.8 15705.8 14345.6 15914.7 0.886581632986048 0.143260852087688 -0.173674619903266 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) acetyl-CoA C-acetyltransferase 2.3.1.9 ko00071 Fatty acid degradation ko00072 Synthesis and degradation of ketone bodies ko00280 Valine, leucine and isoleucine degradation ko00310 Lysine degradation ko00380 Tryptophan metabolism ko00620 Pyruvate metabolism ko00630 Glyoxylate and dicarboxylate metabolism ko00640 Propanoate metabolism ko00650 Butanoate metabolism ko00900 Terpenoid backbone biosynthesis ko01100 Metabolic pathways ko01200 Carbon metabolism ko01212 Fatty acid metabolism Acetyl-CoA acetyltransferase I Lipid transport and metabolism ; IPR020616 [Thiolase, N-terminal] ; IPR020617[Thiolase, C-terminal] -- -- P80316 T-complex protein 1 subunit epsilon Cct5 13170.9 13157.2 13515.1 12596.7 12947.7 12665.8 1.04273727957456 0.0266154853136049 0.0603757127961811 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) T-complex protein 1 subunit epsilon -- -- Chaperonin complex component, TCP-1 epsilon subunit (CCT5) O Posttranslational modification, protein turnover, chaperones ; IPR002423 [Chaperonin Cpn60/TCP-1 family] -- -- E9Q8Z5 Catenin delta-1 Ctnnd1 97 101.9 111.3 145.3 133.4 118.6 0.780770198842185 0.0298377720775154 -0.357030107052008 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) catenin (cadherin-associated protein), delta 1 -- ko04015 Rap1 signaling pathway ko04520 Adherens junction ko04670 Leukocyte transendothelial migration Neural adherens junction protein Plakophilin and related Armadillo repeat proteins TW Signal transduction mechanisms ; Extracellular structures ; IPR000225 [Armadillo] -- -- P97429 Annexin A4 Anxa4 9525.7 9048.7 10671.7 11740.3 11882 11768.4 0.826378116284787 0.0500421563125539 -0.275126044877808 Nonsignificant None 2 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:calcium-dependent phospholipid binding (GO:0005544) annexin A4 -- -- Annexin U Intracellular trafficking, secretion, and vesicular transport ; IPR018502 [Annexin repeat] -- -- Q5SWR1 AP complex subunit beta Ap2b1 5178.3 5260 5007.4 4887.9 4951.3 4851.4 1.05140021510354 0.0345569557023015 0.0723119351800946 Nonsignificant None 4 Biological Process:intracellular protein transport (GO:0006886),Biological Process:vesicle-mediated transport (GO:0016192),Cellular Component:membrane coat (GO:0030117),Cellular Component:clathrin adaptor complex (GO:0030131) AP-2 complex subunit beta-1 -- ko04144 Endocytosis ko04721 Synaptic vesicle cycle ko04961 Endocrine and other factor-regulated calcium reabsorption ko05016 Huntington's disease Vesicle coat complex AP-1/AP-2/AP-4, beta subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR002553 [Clathrin/coatomer adaptor, adaptin-like, N-terminal] ; IPR008152[Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain] ; IPR015151[Beta-adaptin appendage, C-terminal subdomain] -- -- Q8BH64 EH domain-containing protein 2 Ehd2 8329.7 8329 8256.6 9584.1 9446.3 9838 0.863064804422829 0.000357105802208294 -0.212459204649611 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) EH domain-containing protein 2 -- ko04144 Endocytosis Endocytosis/signaling protein EHD1 TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR000261 [EH domain] ; IPR022812[Dynamin superfamily] ; IPR031692[EH domain-containing protein, N-terminal] -- -- P26443 Glutamate dehydrogenase 1, mitochondrial Glud1 10216.9 10132.5 11607 12187.2 11556.1 12021.6 0.893512913498989 0.0689683577019114 -0.162439514914021 Nonsignificant None 3 Biological Process:cellular amino acid metabolic process (GO:0006520),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) glutamate dehydrogenase (NAD(P)+) 1.4.1.3 ko00220 Arginine biosynthesis ko00250 Alanine, aspartate and glutamate metabolism ko00471 D-Glutamine and D-glutamate metabolism ko00910 Nitrogen metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko04217 Necroptosis ko04964 Proximal tubule bicarbonate reclamation Glutamate/leucine/phenylalanine/valine dehydrogenases E Amino acid transport and metabolism ; IPR006096 [Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal] ; IPR006097[Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain] -- -- P17751 Triosephosphate isomerase Tpi1 15548.4 14543.4 16083 16045.9 16063.6 16639.4 0.947196757260164 0.155861504665926 -0.0782639529963955 Nonsignificant None 2 Molecular Function:triose-phosphate isomerase activity (GO:0004807),Biological Process:metabolic process (GO:0008152) triosephosphate isomerase (TIM) 5.3.1.1 ko00010 Glycolysis / Gluconeogenesis ko00051 Fructose and mannose metabolism ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids Triosephosphate isomerase G Carbohydrate transport and metabolism ; IPR000652 [Triosephosphate isomerase] -- -- O88342 WD repeat-containing protein 1 Wdr1 15211.1 15819.1 13833.9 14626.1 14722.4 14197.9 1.03025967703415 0.510644965424735 0.0430080146435179 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- WD40 repeat stress protein/actin interacting protein Z Cytoskeleton ; IPR001680 [WD40 repeat] -- -- Q6PAC1 Gelsolin Gsn 13005.7 13307.2 12516.1 15779.5 15690.5 15555.5 0.825700949484854 0.000337018202293368 -0.276308730693604 Nonsignificant None -- -- gelsolin -- ko04666 Fc gamma R-mediated phagocytosis ko04810 Regulation of actin cytoskeleton ko05203 Viral carcinogenesis Actin regulatory proteins (gelsolin/villin family) Z Cytoskeleton ; IPR007123 [Gelsolin-like domain] -- -- Q61768 Kinesin-1 heavy chain Kif5b 8872.9 8791.4 9989.8 10531.5 10372.2 9969.2 0.895740277071477 0.063508601555617 -0.158847616286007 Nonsignificant None 4 Molecular Function:microtubule motor activity (GO:0003777),Molecular Function:ATP binding (GO:0005524),Biological Process:microtubule-based movement (GO:0007018),Molecular Function:microtubule binding (GO:0008017) kinesin family member 5 -- ko04144 Endocytosis ko04728 Dopaminergic synapse Kinesin (SMY1 subfamily) Z Cytoskeleton ; IPR001752 [Kinesin motor domain] -- -- Q8BPR2 Uncharacterized protein (Fragment) Synm 190.2 203.7 213.2 206.4 210.7 181.1 1.01487796723504 0.807408428394228 0.0213062627314018 Nonsignificant None -- -- desmuslin -- -- -- -- -- -- -- -- E9Q5J9 Tropomyosin alpha-3 chain Tpm3 6260.6 7193.1 6491.1 5324.5 5582.8 5514.8 1.21450971556622 0.0156457203124782 0.280374030972658 Nonsignificant None -- -- tropomyosin 3 -- ko04260 Cardiac muscle contraction ko04261 Adrenergic signaling in cardiomyocytes ko05200 Pathways in cancer ko05216 Thyroid cancer ko05410 Hypertrophic cardiomyopathy (HCM) ko05414 Dilated cardiomyopathy (DCM) Actin filament-coating protein tropomyosin Z Cytoskeleton ; IPR000533 [Tropomyosin] -- -- Q6PB66 Leucine-rich PPR motif-containing protein, mitochondrial Lrpprc 11475.1 11349.9 10934.9 9526.1 9613.8 10105.2 1.15437799836554 0.00346396681098196 0.207115708448839 Nonsignificant None -- -- leucine-rich PPR motif-containing protein, mitochondrial -- -- Bicoid mRNA stability factor A RNA processing and modification ; IPR002885 [Pentatricopeptide repeat] -- -- Q3TF14 Adenosylhomocysteinase Ahcy 357.1 365.2 548.4 516.3 472 544.6 0.82895166025181 0.255637604009023 -0.27064012048643 Nonsignificant None 3 Molecular Function:adenosylhomocysteinase activity (GO:0004013),Biological Process:S-adenosylhomocysteine catabolic process (GO:0019510),Molecular Function:NAD binding (GO:0051287) adenosylhomocysteinase 3.3.1.1 ko00270 Cysteine and methionine metabolism ko01100 Metabolic pathways S-adenosylhomocysteine hydrolase H Coenzyme transport and metabolism ; IPR000043 [Adenosylhomocysteinase] ; IPR015878[S-adenosyl-L-homocysteine hydrolase, NAD binding domain] -- -- Q3TFE8 Importin N-terminal domain-containing protein Kpnb1 11006 11024.5 10772 10082.9 10115.7 9923.1 1.08899896088202 0.000891133356170114 0.123002577442268 Nonsignificant None 2 Biological Process:intracellular protein transport (GO:0006886),Molecular Function:Ran GTPase binding (GO:0008536) importin subunit beta-1 -- ko03013 RNA transport Karyopherin (importin) beta 1 YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; IPR001494 [Importin-beta, N-terminal domain] -- -- Q5U222 Probable ATP-dependent RNA helicase DDX5 (Fragment) Ddx5 8963.4 9104.5 8180.8 6984.4 7061.3 7024.7 1.245761827018 0.026011287322617 0.317028270749695 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase DDX5/DBP2 3.6.4.13 ko03040 Spliceosome ko05202 Transcriptional misregulation in cancer ko05205 Proteoglycans in cancer ATP-dependent RNA helicase A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR011545[DEAD/DEAH box helicase domain] ; IPR012587[RNA helicase p68 repeat] -- -- B2RWW2 Golgb1 protein Golgb1 7405.7 7142.7 7438.4 7878.5 8126.3 7785.4 0.924195677211625 0.012170225557984 -0.113729753359475 Nonsignificant None -- -- golgin subfamily B member 1 -- -- -- -- -- -- -- -- P63101 14-3-3 protein zeta/delta Ywhaz 9930.8 9989.2 10423.3 10768 10801.9 10724.7 0.939578133805652 0.0499721572875028 -0.0899149560553714 Nonsignificant None -- -- 14-3-3 protein beta/theta/zeta -- ko04110 Cell cycle ko04114 Oocyte meiosis ko04151 PI3K-Akt signaling pathway ko04390 Hippo signaling pathway ko05161 Hepatitis B ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis Multifunctional chaperone (14-3-3 family) O Posttranslational modification, protein turnover, chaperones ; IPR023410 [14-3-3 domain] -- -- P24527 Leukotriene A-4 hydrolase Lta4h 12615.6 13785.9 13579.7 14635.7 14403 12213.3 0.96919422088626 0.645052343652368 -0.0451422925780767 Nonsignificant None 2 Molecular Function:metallopeptidase activity (GO:0008237),Molecular Function:zinc ion binding (GO:0008270) leukotriene-A4 hydrolase 3.3.2.6 ko00590 Arachidonic acid metabolism ko01100 Metabolic pathways Bifunctional leukotriene A4 hydrolase/aminopeptidase LTA4H IOVE Lipid transport and metabolism ; Posttranslational modification, protein turnover, chaperones ; Defense mechanisms ; Amino acid transport and metabolism ; IPR014782 [Peptidase M1, membrane alanine aminopeptidase, N-terminal] ; IPR015211[Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal] -- -- Q9WU78 Programmed cell death 6-interacting protein Pdcd6ip 12804.4 12562.5 11954.3 11293.3 11482.9 11266.4 1.09630874257548 0.0139987932251634 0.13265414743791 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) programmed cell death 6-interacting protein -- ko04144 Endocytosis Predicted signal transduction protein R General function prediction only ; IPR004328 [BRO1 domain] ; IPR025304[ALIX V-shaped domain] -- -- B2M1R6 Heterogeneous nuclear ribonucleoprotein K Hnrnpk 12990 13059.5 13463.8 13232.3 13470.3 12872.4 0.99844093493367 0.932486799391662 -0.00225101063195082 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) heterogeneous nuclear ribonucleoprotein K -- ko03040 Spliceosome ko05168 Herpes simplex infection ko05203 Viral carcinogenesis ko05206 MicroRNAs in cancer PolyC-binding hnRNP-K protein HRB57A/hnRNP, contains KH domain AR RNA processing and modification ; General function prediction only ; IPR004088 [K Homology domain, type 1] ; IPR012987[ROK, N-terminal] -- -- Q9D154 Leukocyte elastase inhibitor A Serpinb1a 16185.8 13299.9 11658.6 16313.3 17276.6 16800.3 0.81651392532675 0.084852030519281 -0.292450604288965 Nonsignificant None -- -- serpin B -- ko05146 Amoebiasis Serpin V Defense mechanisms ; IPR023796 [Serpin domain] -- -- Q8C605 ATP-dependent 6-phosphofructokinase Pfkp 8840.9 8463.9 8446.2 8135.8 8190.3 8439.7 1.03978066527227 0.107983035414547 0.0562792336583274 Nonsignificant None 2 Molecular Function:6-phosphofructokinase activity (GO:0003872),Biological Process:glycolytic process (GO:0006096) 6-phosphofructokinase 1 2.7.1.11 ko00010 Glycolysis / Gluconeogenesis ko00030 Pentose phosphate pathway ko00051 Fructose and mannose metabolism ko00052 Galactose metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids ko03018 RNA degradation ko04152 AMPK signaling pathway ko05230 Central carbon metabolism in cancer Pyrophosphate-dependent phosphofructo-1-kinase G Carbohydrate transport and metabolism ; IPR000023 [Phosphofructokinase domain] -- -- Q02788 Collagen alpha-2(VI) chain Col6a2 12854.2 12963.3 13578.1 16666.2 16210.5 16311.5 0.800915666765606 0.000247073523361751 -0.320277754306248 Nonsignificant None -- -- collagen, type VI, alpha -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04974 Protein digestion and absorption ko05165 Human papillomavirus infection Collagens (type IV and type XIII), and related proteins W Extracellular structures ; IPR002035 [von Willebrand factor, type A] ; IPR008160[Collagen triple helix repeat] -- -- Q3UB67 Uncharacterized protein Rpl3 16746.5 15833.8 14125.4 12092.2 11923.9 12291 1.28640679095824 0.0434608253695997 0.363346927655536 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L3e -- ko03010 Ribosome 60S ribosomal protein L3 and related proteins J Translation, ribosomal structure and biogenesis ; IPR000597 [Ribosomal protein L3] -- -- P51881 ADP/ATP translocase 2 Slc25a5 8234.7 8151.7 8694.9 10144.4 10120 9833.7 0.833318382223463 0.0010394649639607 -0.263060289936472 Nonsignificant None -- -- solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31 -- ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04217 Necroptosis ko04218 Cellular senescence ko05012 Parkinson's disease ko05016 Huntington's disease ko05166 HTLV-I infection Mitochondrial ADP/ATP carrier proteins C Energy production and conversion ; IPR018108 [Mitochondrial substrate/solute carrier] -- -- P10493 Nidogen-1 Nid1 7353.5 7741.5 7781.9 8547.9 8545.1 8356.5 0.898913534647046 0.00469240953393198 -0.153745743480415 Nonsignificant None 2 Molecular Function:calcium ion binding (GO:0005509),Biological Process:cell-matrix adhesion (GO:0007160) nidogen (entactin) -- -- Nidogen and related basement membrane protein proteins MW Cell wall/membrane/envelope biogenesis ; Extracellular structures ; IPR000033 [LDLR class B repeat] ; IPR000716[Thyroglobulin type-1] ; IPR001881[EGF-like calcium-binding domain] ; IPR003886[NIDO domain] ; IPR006605[G2 nidogen/fibulin G2F] ; IPR024731[EGF domain] ; IPR026823[Complement Clr-like EGF domain] -- -- Q5SYD0 Unconventional myosin-Id Myo1d 8299.6 7706.5 9166.6 9482.1 9276.5 9750.4 0.882973797748079 0.067074517776549 -0.179557468361056 Nonsignificant None 4 Molecular Function:motor activity (GO:0003774),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Cellular Component:myosin complex (GO:0016459) myosin I -- -- Myosin class I heavy chain Z Cytoskeleton ; IPR000048 [IQ motif, EF-hand binding site] ; IPR001609[Myosin head, motor domain] ; IPR010926[Class I myosin tail homology domain] -- -- O88312 Anterior gradient protein 2 homolog Agr2 15161.7 14687 17095.7 18166.2 15292.5 16048.8 0.948228046255618 0.492541090493277 -0.0766940298176719 Nonsignificant None -- -- anterior gradient protein 2 -- -- -- -- -- -- -- -- Q9D0I9 Arginine--tRNA ligase, cytoplasmic Rars1 8677.3 8632.7 9072.9 8525.8 8695.4 8359.2 1.03137167518882 0.191255672226866 0.0445643301089948 Nonsignificant None 5 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:arginine-tRNA ligase activity (GO:0004814),Molecular Function:ATP binding (GO:0005524),Cellular Component:cytoplasm (GO:0005737),Biological Process:arginyl-tRNA aminoacylation (GO:0006420) arginyl-tRNA synthetase 6.1.1.19 ko00970 Aminoacyl-tRNA biosynthesis Arginyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR001278 [Arginine-tRNA ligase] ; IPR005148[Arginyl tRNA synthetase N-terminal domain] ; IPR008909[DALR anticodon binding] -- -- Q3U1J4 DNA damage-binding protein 1 Ddb1 10614.7 10182.7 9893.1 9878.2 9713.3 10221.3 1.0294403746042 0.319451237715458 0.0418602711999169 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Cellular Component:nucleus (GO:0005634) DNA damage-binding protein 1 -- ko03420 Nucleotide excision repair ko04120 Ubiquitin mediated proteolysis ko05161 Hepatitis B ko05203 Viral carcinogenesis Damage-specific DNA binding complex, subunit DDB1 L Replication, recombination and repair ; IPR004871 [Cleavage/polyadenylation specificity factor, A subunit, C-terminal] -- -- O08749 Dihydrolipoyl dehydrogenase, mitochondrial Dld 9668 9700.4 9842 10067.1 9720.1 10214.7 0.973618337505291 0.166108638390519 -0.0385717543020229 Nonsignificant None 3 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:cell redox homeostasis (GO:0045454),Biological Process:oxidation-reduction process (GO:0055114) dihydrolipoamide dehydrogenase 1.8.1.4 ko00010 Glycolysis / Gluconeogenesis ko00020 Citrate cycle (TCA cycle) ko00260 Glycine, serine and threonine metabolism ko00280 Valine, leucine and isoleucine degradation ko00620 Pyruvate metabolism ko00630 Glyoxylate and dicarboxylate metabolism ko00640 Propanoate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism Dihydrolipoamide dehydrogenase C Energy production and conversion ; IPR004099 [Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain] ; IPR023753[FAD/NAD(P)-binding domain] -- -- Q3TXS7 26S proteasome non-ATPase regulatory subunit 1 Psmd1 9000.5 8374.6 8852.3 7911.7 8292.8 7918.1 1.08725427607306 0.0365517342206844 0.120689382802687 Nonsignificant None -- -- 26S proteasome regulatory subunit N2 -- ko03050 Proteasome ko05169 Epstein-Barr virus infection 26S proteasome regulatory complex, subunit RPN2/PSMD1 O Posttranslational modification, protein turnover, chaperones ; IPR002015 [Proteasome/cyclosome repeat] -- -- Q3UW64 Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase Gne 8005 7554.7 6826.3 7749.3 7557.4 8330.4 0.947070495111499 0.371431974007322 -0.0784562783145607 Nonsignificant None -- -- -- -- ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways -- -- -- IPR000600 [ROK family] ; IPR003331[UDP-N-acetylglucosamine 2-epimerase domain] -- -- E9Q0S6 Tensin 1 Tns1 10039.7 10406.3 10210.4 12868.8 12269.1 12287.3 0.819137907078653 0.000542797018043645 -0.287821735683319 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) tensin -- -- Clathrin coat dissociation kinase GAK/PTEN/Auxilin and related tyrosine phosphatases TR Signal transduction mechanisms ; General function prediction only ; IPR000980 [SH2 domain] ; IPR013625[Tensin/EPS8 phosphotyrosine-binding domain] ; IPR014020[Tensin phosphatase, C2 domain] -- -- Q9WVA4 Transgelin-2 Tagln2 11389.4 11081.8 10170.8 10605.8 10543.9 10534.2 1.03023933291041 0.474888102449074 0.0429795260431356 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) transgelin -- -- Calponin Z Cytoskeleton ; IPR000557 [Calponin repeat] ; IPR001715[Calponin homology domain] -- -- Q91VD9 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial Ndufs1 7504.9 7565 8788.3 10667.9 10297 10608.5 0.755642407849646 0.00405274097889496 -0.404224424556603 Nonsignificant None 3 Molecular Function:oxidoreductase activity (GO:0016491),Molecular Function:iron-sulfur cluster binding (GO:0051536),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease NADH-ubiquinone oxidoreductase, NDUFS1/75 kDa subunit C Energy production and conversion ; IPR006656 [Molybdopterin oxidoreductase] ; IPR015405[NADH-quinone oxidoreductase, chain G, C-terminal] ; IPR019574[NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding] -- -- P08249 Malate dehydrogenase, mitochondrial Mdh2 14166.3 13445.8 15415.9 16621.9 16034.7 16630.1 0.873014423769496 0.0265498651687476 -0.195922604917161 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) malate dehydrogenase 1.1.1.37 ko00020 Citrate cycle (TCA cycle) ko00270 Cysteine and methionine metabolism ko00620 Pyruvate metabolism ko00630 Glyoxylate and dicarboxylate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism NAD-dependent malate dehydrogenase C Energy production and conversion ; IPR001236 [Lactate/malate dehydrogenase, N-terminal] ; IPR022383[Lactate/malate dehydrogenase, C-terminal] -- -- Q922B2 Aspartate--tRNA ligase, cytoplasmic Dars1 11003.7 10999.1 11735.3 10959.9 10797.8 11190.9 1.02396156437603 0.384776188078937 0.0341615630676078 Nonsignificant None 5 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation for protein translation (GO:0006418) Aspartyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR004364 [Aminoacyl-tRNA synthetase, class II (D/K/N)] ; IPR004365[OB-fold nucleic acid binding domain, AA-tRNA synthetase-type] -- -- Q9D8E6 60S ribosomal protein L4 Rpl4 17552.3 17036.4 15693.7 14195.4 13925.3 13634.4 1.20422175973713 0.00790100713285399 0.268101091610247 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L4e -- ko03010 Ribosome Ribosomal protein RPL1/RPL2/RL4L4 A RNA processing and modification ; IPR002136 [Ribosomal protein L4/L1e] ; IPR025755[60S ribosomal protein L4, C-terminal domain] -- -- A2AN08 E3 ubiquitin-protein ligase UBR4 Ubr4 5633.6 5402.8 5580.8 6187 6098.8 6061.5 0.905702746453157 0.00188253060020761 -0.142890462479357 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) E3 ubiquitin-protein ligase UBR4 2.3.2.27 ko05165 Human papillomavirus infection ko05203 Viral carcinogenesis Zn-binding protein Push T Signal transduction mechanisms ; IPR003126 [Zinc finger, UBR-type] ; IPR025704[E3 ubiquitin ligase, UBR4] -- -- Q00PI9 Heterogeneous nuclear ribonucleoprotein U-like protein 2 Hnrnpul2 8567.1 8471.9 9479.6 9184.6 9152.5 9576.8 0.950014150656125 0.253455701436937 -0.0739790920444376 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Scaffold/matrix specific factor hnRNP-U/SAF-A, contains SPRY domain A RNA processing and modification ; IPR003034 [SAP domain] ; IPR003877[SPRY domain] -- -- Q3U4U6 T-complex protein 1 subunit gamma Cct3 14200 14249.1 14341.3 13244.5 13071.2 12939.2 1.09006518931395 0.000270035041699355 0.124414415266147 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) T-complex protein 1 subunit gamma -- -- Chaperonin complex component, TCP-1 gamma subunit (CCT3) O Posttranslational modification, protein turnover, chaperones ; IPR002423 [Chaperonin Cpn60/TCP-1 family] -- -- Q60675 Laminin subunit alpha-2 Lama2 7875.9 7808.1 7875.5 8579.7 8717.9 9179.9 0.88979322065905 0.0314443704234802 -0.168457988235685 Nonsignificant None 5 Molecular Function:receptor binding (GO:0005102),Biological Process:cell adhesion (GO:0007155),Biological Process:regulation of cell adhesion (GO:0030155),Biological Process:regulation of cell migration (GO:0030334),Biological Process:regulation of embryonic development (GO:0045995) laminin, alpha 1/2 -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko05145 Toxoplasmosis ko05146 Amoebiasis ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05222 Small cell lung cancer Extracellular matrix glycoprotein Laminin subunits alpha and gamma W Extracellular structures ; IPR000034 [Laminin IV] ; IPR001791[Laminin G domain] ; IPR002049[Laminin EGF domain] ; IPR008211[Laminin, N-terminal] ; IPR009254[Laminin alpha, domain I] ; IPR010307[Laminin domain II] -- -- P09055 Integrin beta-1 Itgb1 10341.2 10655.2 10493.7 11008.4 10616.4 10646 0.975807851060401 0.168988159331818 -0.0353310040805433 Nonsignificant None -- -- integrin beta 1 -- ko04015 Rap1 signaling pathway ko04145 Phagosome ko04151 PI3K-Akt signaling pathway ko04360 Axon guidance ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04514 Cell adhesion molecules (CAMs) ko04530 Tight junction ko04611 Platelet activation ko04670 Leukocyte transendothelial migration ko04810 Regulation of actin cytoskeleton ko05100 Bacterial invasion of epithelial cells ko05133 Pertussis ko05140 Leishmaniasis ko05145 Toxoplasmosis ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05222 Small cell lung cancer ko05410 Hypertrophic cardiomyopathy (HCM) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05414 Dilated cardiomyopathy (DCM) Integrin beta subunit (N-terminal portion of extracellular region) TW Signal transduction mechanisms ; Extracellular structures ; IPR002369 [Integrin beta subunit, VWA domain] ; IPR012896[Integrin beta subunit, tail] ; IPR013111[EGF-like domain, extracellular] ; IPR014836[Integrin beta subunit, cytoplasmic domain] ; IPR033760[Integrin beta N-terminal] -- -- Q64737 Trifunctional purine biosynthetic protein adenosine-3 Gart 8038.2 7827.2 7311.2 7094.2 7013.8 6965.8 1.0997826685268 0.0329551024685253 0.137218456462037 Nonsignificant None 3 Molecular Function:phosphoribosylamine-glycine ligase activity (GO:0004637),Biological Process:biosynthetic process (GO:0009058),Biological Process:purine nucleobase biosynthetic process (GO:0009113) -- -- ko00230 Purine metabolism ko00670 One carbon pool by folate ko01100 Metabolic pathways ko01523 Antifolate resistance Glycinamide ribonucleotide synthetase (GARS)/Aminoimidazole ribonucleotide synthetase (AIRS) F Nucleotide transport and metabolism ; IPR002376 [Formyl transferase, N-terminal] ; IPR010918[AIR synthase-related protein, C-terminal domain] ; IPR016188[PurM-like, N-terminal domain] ; IPR020560[Phosphoribosylglycinamide synthetase, C-domain] ; IPR020561[Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain] ; IPR020562[Phosphoribosylglycinamide synthetase, N-terminal] -- -- G3X8Q5 Ceruloplasmin Cp 10534.3 10399.3 8909.4 5687.6 6164.1 5758.8 1.694614008688 0.0016635899498604 0.760956700401612 Significant up 3 Molecular Function:copper ion binding (GO:0005507),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) ceruloplasmin 1.16.3.1 ko00860 Porphyrin and chlorophyll metabolism ko04216 Ferroptosis Multicopper oxidases Q Secondary metabolites biosynthesis, transport and catabolism ; IPR001117 [Multicopper oxidase, type 1] ; IPR011706[Multicopper oxidase, type 2] ; IPR011707[Multicopper oxidase, type 3] -- -- Q9EPU0 Regulator of nonsense transcripts 1 Upf1 9153.9 9215.2 8838.8 8381.5 8371.2 8226.3 1.08923095400136 0.00424789962763936 0.123309886897316 Nonsignificant None 6 Molecular Function:DNA binding (GO:0003677),Molecular Function:helicase activity (GO:0004386),Molecular Function:ATP binding (GO:0005524),Cellular Component:cytoplasm (GO:0005737),Molecular Function:zinc ion binding (GO:0008270),Molecular Function:hydrolase activity (GO:0016787) regulator of nonsense transcripts 1 3.6.4.- ko03013 RNA transport ko03015 mRNA surveillance pathway RNA helicase nonsense mRNA reducing factor (pNORF1) A RNA processing and modification ; IPR006935 [Helicase/UvrB, N-terminal] ; IPR018999[RNA helicase UPF1, UPF2-interacting domain] -- -- Q9Z2I8 Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial Suclg2 8464.3 7805.5 10018.3 12076.9 10943.9 12097.6 0.748556312360472 0.0178457217956708 -0.417817243523779 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) -- -- ko00020 Citrate cycle (TCA cycle) ko00640 Propanoate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism GTP-specific succinyl-CoA synthetase, beta subunit C Energy production and conversion ; IPR005811 [ATP-citrate lyase/succinyl-CoA ligase] ; IPR013650[ATP-grasp fold, succinyl-CoA synthetase-type] -- -- P12382 ATP-dependent 6-phosphofructokinase, liver type Pfkl 5944.6 5622.6 6263 5818.6 5686.2 6123.5 1.01145317472473 0.780407214946953 0.0164295318031516 Nonsignificant None 2 Molecular Function:6-phosphofructokinase activity (GO:0003872),Biological Process:glycolytic process (GO:0006096) 6-phosphofructokinase 1 2.7.1.11 ko00010 Glycolysis / Gluconeogenesis ko00030 Pentose phosphate pathway ko00051 Fructose and mannose metabolism ko00052 Galactose metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids ko03018 RNA degradation ko04152 AMPK signaling pathway ko05230 Central carbon metabolism in cancer Pyrophosphate-dependent phosphofructo-1-kinase G Carbohydrate transport and metabolism ; IPR000023 [Phosphofructokinase domain] -- -- P40124 Adenylyl cyclase-associated protein 1 Cap1 11427.1 11916.8 9923.8 10003.6 9860.9 9986 1.11447714443644 0.197262164821937 0.156367030284243 Nonsignificant None 2 Molecular Function:actin binding (GO:0003779),Biological Process:cytoskeleton organization (GO:0007010) adenylyl cyclase-associated protein -- -- Adenylate cyclase-associated protein (CAP/Srv2p) ZT Cytoskeleton ; Signal transduction mechanisms ; IPR013912 [Adenylate cyclase-associated CAP, C-terminal] ; IPR013992[Adenylate cyclase-associated CAP, N-terminal] -- -- Q8BMK4 Cytoskeleton-associated protein 4 Ckap4 9434.4 9810.9 9261.7 8714.2 8912.9 8140.3 1.10632038932915 0.0319808406603525 0.145769249189285 Nonsignificant None -- -- cytoskeleton-associated protein 4 -- ko04141 Protein processing in endoplasmic reticulum -- -- -- -- -- -- P06745 Glucose-6-phosphate isomerase Gpi 17063.8 16543.4 14675.4 13291.8 13231.6 13112 1.21816860685145 0.0571328973473872 0.284713830644624 Nonsignificant None 3 Molecular Function:glucose-6-phosphate isomerase activity (GO:0004347),Biological Process:gluconeogenesis (GO:0006094),Biological Process:glycolytic process (GO:0006096) glucose-6-phosphate isomerase 5.3.1.9 ko00010 Glycolysis / Gluconeogenesis ko00030 Pentose phosphate pathway ko00500 Starch and sucrose metabolism ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism Glucose-6-phosphate isomerase G Carbohydrate transport and metabolism ; IPR001672 [Phosphoglucose isomerase (PGI)] -- -- A0A0R4J259 Heterogeneous nuclear ribonucleoprotein Q Syncrip 9271.8 9264.4 8217.3 8173 8199.5 7974.8 1.09882820682375 0.0881984370805981 0.135965849856987 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) heterogeneous nuclear ribonucleoprotein Q -- -- Heterogeneous nuclear ribonucleoprotein R (RRM superfamily) A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- Q8JZQ9 Eukaryotic translation initiation factor 3 subunit B Eif3b 8090.2 8001.7 7295.8 6563.8 6679.1 6657.8 1.17521996713683 0.0413608857880419 0.232930812787444 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) translation initiation factor 3 subunit B -- ko03013 RNA transport Translation initiation factor 3, subunit b (eIF-3b) J Translation, ribosomal structure and biogenesis ; IPR000504 [RNA recognition motif domain] ; IPR013979[Translation initiation factor, beta propellor-like domain] -- -- B7U582 Heat shock protein 70-2 2199.7 2074.1 1947.2 2183.6 2153.6 2304.8 0.936615477265884 0.179288750276287 -0.0944712165874692 Nonsignificant None -- -- heat shock 70kDa protein 1/2/6/8 -- ko03040 Spliceosome ko04010 MAPK signaling pathway ko04141 Protein processing in endoplasmic reticulum ko04144 Endocytosis ko04213 Longevity regulating pathway - multiple species ko04612 Antigen processing and presentation ko04915 Estrogen signaling pathway ko05134 Legionellosis ko05145 Toxoplasmosis ko05162 Measles ko05164 Influenza A ko05169 Epstein-Barr virus infection Molecular chaperones HSP70/HSC70, HSP70 superfamily O Posttranslational modification, protein turnover, chaperones ; IPR013126 [Heat shock protein 70 family] -- -- Q6ZQ49 Sodium/potassium-transporting ATPase subunit alpha (Fragment) Atp1a2 277.5 271.5 301.7 315.7 364.5 322.5 0.84840929490376 0.046824556661749 -0.237167668221979 Nonsignificant None 2 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:metal ion binding (GO:0046872) sodium/potassium-transporting ATPase subunit alpha 3.6.3.9 ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04260 Cardiac muscle contraction ko04261 Adrenergic signaling in cardiomyocytes ko04911 Insulin secretion ko04918 Thyroid hormone synthesis ko04919 Thyroid hormone signaling pathway ko04925 Aldosterone synthesis and secretion ko04960 Aldosterone-regulated sodium reabsorption ko04961 Endocrine and other factor-regulated calcium reabsorption ko04964 Proximal tubule bicarbonate reclamation ko04970 Salivary secretion ko04971 Gastric acid secretion ko04972 Pancreatic secretion ko04973 Carbohydrate digestion and absorption ko04974 Protein digestion and absorption ko04976 Bile secretion ko04978 Mineral absorption Na+/K+ ATPase, alpha subunit P Inorganic ion transport and metabolism ; IPR004014 [Cation-transporting P-type ATPase, N-terminal] ; IPR006068[Cation-transporting P-type ATPase, C-terminal] ; IPR008250[P-type ATPase, A domain] -- -- A1E281 Beta-actin (Fragment) Actb 233.1 201.2 158.8 189.7 163.4 181.1 1.1102583302134 0.439031538427234 0.150895395815254 Nonsignificant None -- -- -- -- -- Actin and related proteins Z Cytoskeleton ; IPR004000 [Actin family] -- -- E9PZF0 Nucleoside diphosphate kinase Gm20390 5199.8 4666.7 4501.3 4664.8 4902.6 4698 1.00717820741094 0.886000924455805 0.0103189725219266 Nonsignificant None 5 Molecular Function:nucleoside diphosphate kinase activity (GO:0004550),Biological Process:nucleoside diphosphate phosphorylation (GO:0006165),Biological Process:GTP biosynthetic process (GO:0006183),Biological Process:UTP biosynthetic process (GO:0006228),Biological Process:CTP biosynthetic process (GO:0006241) nucleoside-diphosphate kinase 2.7.4.6 ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways Nucleoside diphosphate kinase F Nucleotide transport and metabolism ; IPR001564 [Nucleoside diphosphate kinase] -- -- P39054 Dynamin-2 Dnm2 4844.7 4717.3 4688.4 4674 4731.3 4841.9 1.00022460553653 0.988372661633152 0.000324000908865908 Nonsignificant None 2 Molecular Function:GTPase activity (GO:0003924),Molecular Function:GTP binding (GO:0005525) dynamin GTPase 3.6.5.5 ko04072 Phospholipase D signaling pathway ko04144 Endocytosis ko04721 Synaptic vesicle cycle ko04961 Endocrine and other factor-regulated calcium reabsorption ko05100 Bacterial invasion of epithelial cells Vacuolar sorting protein VPS1, dynamin, and related proteins UR Intracellular trafficking, secretion, and vesicular transport ; General function prediction only ; IPR000375 [Dynamin central domain] ; IPR001849[Pleckstrin homology domain] ; IPR003130[Dynamin GTPase effector] ; IPR022812[Dynamin superfamily] -- -- Q9QUR6 Prolyl endopeptidase Prep 8691.7 8547.5 8582.5 8027.1 8010.2 8159.6 1.06714909761168 0.00107897369524349 0.0937617575659673 Nonsignificant None 4 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508),Molecular Function:serine-type peptidase activity (GO:0008236),Molecular Function:serine-type exopeptidase activity (GO:0070008) prolyl oligopeptidase 3.4.21.26 ko04614 Renin-angiotensin system Predicted serine protease O Posttranslational modification, protein turnover, chaperones ; IPR001375 [Peptidase S9, prolyl oligopeptidase, catalytic domain] ; IPR023302[Peptidase S9A, N-terminal domain] -- -- Q3U3A8 Calpain-2 catalytic subunit Capn2 6703.4 6812.6 6216.3 6943.7 6822.8 7140.9 0.943795019945091 0.129199991983971 -0.0834545359570818 Nonsignificant None 4 Molecular Function:calcium-dependent cysteine-type endopeptidase activity (GO:0004198),Molecular Function:calcium ion binding (GO:0005509),Cellular Component:intracellular (GO:0005622),Biological Process:proteolysis (GO:0006508) calpain-2 3.4.22.53 ko04141 Protein processing in endoplasmic reticulum ko04210 Apoptosis ko04217 Necroptosis ko04218 Cellular senescence ko04510 Focal adhesion ko05010 Alzheimer's disease Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) OT Posttranslational modification, protein turnover, chaperones ; Signal transduction mechanisms ; IPR001300 [Peptidase C2, calpain, catalytic domain] ; IPR002048[EF-hand domain] ; IPR022682[Peptidase C2, calpain, large subunit, domain III] -- -- P60335 Poly(rC)-binding protein 1 Pcbp1 6686.8 7024.1 7177.4 6820 7019.5 6554.1 1.02425761023066 0.451597253532401 0.0345786120774243 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) poly(rC)-binding protein 1 -- ko03040 Spliceosome ko04216 Ferroptosis PolyC-binding proteins alphaCP-1 and related KH domain proteins AR RNA processing and modification ; General function prediction only ; IPR004088 [K Homology domain, type 1] -- -- Q8K0E8 Fibrinogen beta chain Fgb 15985.8 17235.3 12188.4 8198.1 8562.2 7530 1.86944994503979 0.0104211549646624 0.902613843215535 Significant up 5 Molecular Function:receptor binding (GO:0005102),Cellular Component:fibrinogen complex (GO:0005577),Biological Process:signal transduction (GO:0007165),Biological Process:platelet activation (GO:0030168),Biological Process:protein polymerization (GO:0051258) fibrinogen beta chain -- ko04610 Complement and coagulation cascades ko04611 Platelet activation Ficolin and related extracellular proteins R General function prediction only ; IPR002181 [Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain] ; IPR012290[Fibrinogen, alpha/beta/gamma chain, coiled coil domain] -- -- Q9CPQ9 Fructose-bisphosphate aldolase Aldoart1 33.1 38.8 53.3 41.9 44.2 43.9 0.963076923076923 0.815744438843351 -0.0542770609831986 Nonsignificant None 2 Molecular Function:fructose-bisphosphate aldolase activity (GO:0004332),Biological Process:glycolytic process (GO:0006096) fructose-bisphosphate aldolase, class I 4.1.2.13 ko00010 Glycolysis / Gluconeogenesis ko00030 Pentose phosphate pathway ko00051 Fructose and mannose metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids Fructose-biphosphate aldolase G Carbohydrate transport and metabolism ; IPR000741 [Fructose-bisphosphate aldolase, class-I] -- -- E9PVC5 Eukaryotic translation initiation factor 4 gamma 1 Eif4g1 318.4 318.9 332.2 322.8 310.4 333.7 1.00268900610198 0.920013303199812 0.00387420921345337 Nonsignificant None 2 Molecular Function:RNA binding (GO:0003723),Molecular Function:protein binding (GO:0005515) translation initiation factor 4G -- ko03013 RNA transport ko05416 Viral myocarditis Translation initiation factor 4F, ribosome/mRNA-bridging subunit (eIF-4G) J Translation, ribosomal structure and biogenesis ; IPR003307 [W2 domain] ; IPR003890[MIF4G-like, type 3] ; IPR003891[Initiation factor eIF-4 gamma, MA3] -- -- P22599 Alpha-1-antitrypsin 1-2 Serpina1b 622.6 589.7 469.8 331.8 362.1 386.6 1.55677926885701 0.0150078592227266 0.638564403440601 Significant up -- -- alpha-1-antitrypsin -- ko04610 Complement and coagulation cascades Serpin V Defense mechanisms ; IPR023796 [Serpin domain] -- -- E9Q9E1 Eukaryotic translation initiation factor 4 gamma 1 Eif4g1 302 275.6 241.8 220.8 247.7 237.5 1.16062322946176 0.118999508402362 0.214899709321758 Nonsignificant None 2 Molecular Function:RNA binding (GO:0003723),Molecular Function:protein binding (GO:0005515) translation initiation factor 4G -- ko03013 RNA transport ko05416 Viral myocarditis Translation initiation factor 4F, ribosome/mRNA-bridging subunit (eIF-4G) J Translation, ribosomal structure and biogenesis ; IPR003307 [W2 domain] ; IPR003890[MIF4G-like, type 3] ; IPR003891[Initiation factor eIF-4 gamma, MA3] -- -- P27546 Microtubule-associated protein 4 Map4 8281.9 8491.1 8682.5 8179.6 8406.2 7768.2 1.04522870986286 0.169939306909139 0.0638186576005704 Nonsignificant None 1 Molecular Function:tubulin binding (GO:0015631) microtubule-associated protein 4 -- -- -- -- -- IPR001084 [Microtubule associated protein, tubulin-binding repeat] -- -- Q3U0V1 Far upstream element-binding protein 2 Khsrp 5906.2 6027.6 6449 6819.8 6828.5 6590 0.908317398200442 0.0273533526986994 -0.138731580635838 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) far upstream element-binding protein -- -- K-homology type RNA binding proteins A RNA processing and modification ; IPR004088 [K Homology domain, type 1] ; IPR015096[Domain of unknown function DUF1897] -- -- A0A0U1RP81 MICOS complex subunit MIC60 Immt 222.7 234.7 364.9 323.2 320.5 295.9 0.875159642401022 0.446423349408142 -0.192381884465266 Nonsignificant None -- -- mitofilin -- -- Mitochondrial inner membrane protein (mitofilin) M Cell wall/membrane/envelope biogenesis ; IPR019133 [Mitochondrial inner membrane protein Mitofilin] -- -- P50544 Very long-chain specific acyl-CoA dehydrogenase, mitochondrial Acadvl 7830.8 7784.4 10400.8 10111.4 9001.8 9976.4 0.894340245311039 0.333587656729145 -0.161104296099512 Nonsignificant None 4 Molecular Function:acyl-CoA dehydrogenase activity (GO:0003995),Biological Process:metabolic process (GO:0008152),Molecular Function:flavin adenine dinucleotide binding (GO:0050660),Biological Process:oxidation-reduction process (GO:0055114) very long chain acyl-CoA dehydrogenase 1.3.8.9 ko00071 Fatty acid degradation ko01100 Metabolic pathways ko01212 Fatty acid metabolism Very-long-chain acyl-CoA dehydrogenase I Lipid transport and metabolism ; IPR006091 [Acyl-CoA oxidase/dehydrogenase, central domain] ; IPR009075[Acyl-CoA dehydrogenase/oxidase C-terminal] ; IPR013786[Acyl-CoA dehydrogenase/oxidase, N-terminal] -- -- Q5DTP7 DNA helicase (Fragment) Chd4 6744 6575.1 6544.4 5936.1 5962.8 6191 1.09804365972172 0.00439693627968271 0.134935419016847 Nonsignificant None 5 Molecular Function:DNA binding (GO:0003677),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Cellular Component:nucleus (GO:0005634),Molecular Function:zinc ion binding (GO:0008270) chromodomain-helicase-DNA-binding protein 4 3.6.4.12 ko05165 Human papillomavirus infection ko05203 Viral carcinogenesis Predicted helicase R General function prediction only ; IPR000330 [SNF2-related, N-terminal domain] ; IPR001650[Helicase, C-terminal] ; IPR009462[Domain of unknown function DUF1086] ; IPR009463[Domain of unknown function DUF1087] ; IPR012957[CHD, C-terminal 2] ; IPR012958[CHD, N-terminal] ; IPR019787[Zinc finger, PHD-finger] ; IPR023780[Chromo domain] -- -- P29341 Polyadenylate-binding protein 1 Pabpc1 13640.5 13259.2 13258.2 11616.3 11790.5 11754 1.14212133967373 0.000269249469534825 0.19171593165188 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:RNA binding (GO:0003723) polyadenylate-binding protein -- ko03013 RNA transport ko03015 mRNA surveillance pathway ko03018 RNA degradation Polyadenylate-binding protein (RRM superfamily) AJ RNA processing and modification ; Translation, ribosomal structure and biogenesis ; IPR000504 [RNA recognition motif domain] ; IPR002004[Polyadenylate-binding protein/Hyperplastic disc protein] -- -- P62702 40S ribosomal protein S4, X isoform Rps4x 6197.3 6470 7188.1 6115.8 6154.9 5989.5 1.08735939365396 0.150676525801921 0.120828858255178 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) small subunit ribosomal protein S4e -- ko03010 Ribosome 40S ribosomal protein S4 J Translation, ribosomal structure and biogenesis ; IPR002942 [RNA-binding S4 domain] ; IPR005824[KOW] ; IPR013843[Ribosomal protein S4e, N-terminal] ; IPR013845[Ribosomal protein S4e, central region] ; IPR032277[40S ribosomal protein S4, C-terminal domain] -- -- Q3U4D1 Adenosylhomocysteinase 21.3 48.3 103 83.6 76.9 56.1 0.796860572483841 0.594851957295298 -0.327600778429372 Nonsignificant None 3 Molecular Function:adenosylhomocysteinase activity (GO:0004013),Biological Process:S-adenosylhomocysteine catabolic process (GO:0019510),Molecular Function:NAD binding (GO:0051287) adenosylhomocysteinase 3.3.1.1 ko00270 Cysteine and methionine metabolism ko01100 Metabolic pathways S-adenosylhomocysteine hydrolase H Coenzyme transport and metabolism ; IPR000043 [Adenosylhomocysteinase] ; IPR015878[S-adenosyl-L-homocysteine hydrolase, NAD binding domain] -- -- Q9DBR7 Protein phosphatase 1 regulatory subunit 12A Ppp1r12a 9113 9670.8 10109.8 10621.1 10382.7 10006.8 0.931733020322083 0.1060943170402 -0.102011472020261 Nonsignificant None 1 Molecular Function:protein kinase binding (GO:0019901) protein phosphatase 1 regulatory subunit 12A -- ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04270 Vascular smooth muscle contraction ko04510 Focal adhesion ko04611 Platelet activation ko04810 Regulation of actin cytoskeleton ko04921 Oxytocin signaling pathway ko05205 Proteoglycans in cancer Myosin phosphatase, regulatory subunit OT Posttranslational modification, protein turnover, chaperones ; Signal transduction mechanisms ; IPR020683 [Ankyrin repeat-containing domain] ; IPR031775[cGMP-dependent protein kinase, interacting domain] -- -- Q505N6 Ribosomal protein S6 kinase Rps6ka1 6761.5 6650 6703.2 6786.8 6784.4 6844.6 0.985251618844229 0.0564073931746202 -0.021435880063333 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) ribosomal protein S6 kinase alpha-1/2/3/6 2.7.11.1 ko04010 MAPK signaling pathway ko04114 Oocyte meiosis ko04150 mTOR signaling pathway ko04720 Long-term potentiation ko04722 Neurotrophin signaling pathway ko04914 Progesterone-mediated oocyte maturation ko04931 Insulin resistance Ribosomal protein S6 kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR017892[Protein kinase, C-terminal] -- -- Q8BML9 Glutamine--tRNA ligase Qars1 8971.6 8680.7 8449 7970.1 8037.6 8326 1.07264000131505 0.0341866256296746 0.101165961031273 Nonsignificant None 8 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:glutamine-tRNA ligase activity (GO:0004819),Molecular Function:ATP binding (GO:0005524),Cellular Component:cytoplasm (GO:0005737),Biological Process:tRNA aminoacylation for protein translation (GO:0006418),Biological Process:glutaminyl-tRNA aminoacylation (GO:0006425),Biological Process:tRNA aminoacylation (GO:0043039) glutaminyl-tRNA synthetase 6.1.1.18 ko00970 Aminoacyl-tRNA biosynthesis ko01100 Metabolic pathways Glutaminyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR007638 [Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2] ; IPR007639[Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal] ; IPR020058[Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain] ; IPR020059[Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain] -- -- Q3U5Q3 116 kDa U5 small nuclear ribonucleoprotein component Eftud2 6892.3 6616.4 6724.6 6248.3 6392.1 6380 1.06376837500789 0.0119749059552632 0.0891840525258526 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) 116 kDa U5 small nuclear ribonucleoprotein component -- ko03040 Spliceosome U5 snRNP-specific protein J Translation, ribosomal structure and biogenesis ; IPR000640 [Translation elongation factor EFG, V domain] ; IPR004161[Translation elongation factor EFTu-like, domain 2] ; IPR005517[Translation elongation factor EFG/EF2, domain IV] ; IPR009022[Elongation factor G, III-V domain] ; IPR031950[116 kDa U5 small nuclear ribonucleoprotein component, N-terminal] -- -- P18760 Cofilin-1 Cfl1 14970.4 16348.5 13264.6 11682.5 12020.7 12011.9 1.24830953854252 0.0780422015756696 0.319975718133326 Nonsignificant None 2 Molecular Function:actin binding (GO:0003779),Cellular Component:intracellular (GO:0005622) cofilin -- ko04360 Axon guidance ko04666 Fc gamma R-mediated phagocytosis ko04810 Regulation of actin cytoskeleton ko05133 Pertussis Actin depolymerizing factor Z Cytoskeleton ; IPR002108 [Actin-depolymerising factor homology domain] -- -- Q3TS38 UDP-glucose 6-dehydrogenase Ugdh 9145.2 9193.7 10365.9 12768.7 11887.1 11887.3 0.785505334796446 0.00620264433305896 -0.348307021203357 Nonsignificant None 2 Molecular Function:NAD binding (GO:0051287),Biological Process:oxidation-reduction process (GO:0055114) UDPglucose 6-dehydrogenase 1.1.1.22 ko00040 Pentose and glucuronate interconversions ko00053 Ascorbate and aldarate metabolism ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways UDP-glucose/GDP-mannose dehydrogenase GT Carbohydrate transport and metabolism ; Signal transduction mechanisms ; IPR001732 [UDP-glucose/GDP-mannose dehydrogenase, N-terminal] ; IPR014026[UDP-glucose/GDP-mannose dehydrogenase, dimerisation] ; IPR014027[UDP-glucose/GDP-mannose dehydrogenase, C-terminal] -- -- Q3TGU7 Peptidase_M24 domain-containing protein Pa2g4 11772 11809.2 11331.4 11170.4 11200.1 10973.3 1.04704922654287 0.0365158464536212 0.0663292715139798 Nonsignificant None -- -- -- -- -- Metallopeptidase R General function prediction only ; IPR000994 [Peptidase M24] -- -- Q3TLE2 PH domain-containing protein Fermt2 8271.3 8915.1 8540.2 9093.8 8638.4 9116.2 0.958217249445032 0.198787036877557 -0.0615753103621522 Nonsignificant None -- -- kindlin 2 -- -- Mitogen inducible gene product (contains ERM and PH domains) D Cell cycle control, cell division, chromosome partitioning ; IPR001849 [Pleckstrin homology domain] ; IPR019748[FERM central domain] -- -- Q3UAJ1 Peptidyl-prolyl cis-trans isomerase Ppia 26692.9 28582.7 21463.8 21566.8 22067.6 22185.3 1.16590321742579 0.228755779021818 0.22144803422022 Nonsignificant None 3 Biological Process:protein peptidyl-prolyl isomerization (GO:0000413),Molecular Function:peptidyl-prolyl cis-trans isomerase activity (GO:0003755),Biological Process:protein folding (GO:0006457) peptidyl-prolyl cis-trans isomerase A (cyclophilin A) 5.2.1.8 ko04217 Necroptosis Cyclophilin type peptidyl-prolyl cis-trans isomerase O Posttranslational modification, protein turnover, chaperones ; IPR002130 [Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain] -- -- Q52KG9 Chaperonin containing Tcp1, subunit 6a (Zeta) Cct6a 12430.4 12236.8 12547.5 11620.4 11647.6 11517 1.06984907287624 0.00121324232651253 0.0974072852516196 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) T-complex protein 1 subunit zeta -- -- Chaperonin complex component, TCP-1 zeta subunit (CCT6) O Posttranslational modification, protein turnover, chaperones ; IPR002423 [Chaperonin Cpn60/TCP-1 family] -- -- Q4FK49 Inorganic diphosphatase Ppa1 12564.7 11830.7 9021.8 12770.7 12889.8 12964.1 0.865179186321671 0.248924663249939 -0.208929136189061 Nonsignificant None 4 Molecular Function:magnesium ion binding (GO:0000287),Molecular Function:inorganic diphosphatase activity (GO:0004427),Cellular Component:cytoplasm (GO:0005737),Biological Process:phosphate-containing compound metabolic process (GO:0006796) inorganic pyrophosphatase 3.6.1.1 ko00190 Oxidative phosphorylation Inorganic pyrophosphatase/Nucleosome remodeling factor, subunit NURF38 C Energy production and conversion ; IPR008162 [Inorganic pyrophosphatase] -- -- Q9D8N0 Elongation factor 1-gamma Eef1g 11918.9 11869.9 11442.7 9805.7 10629.5 9816.1 1.16462763583714 0.00600170074091709 0.219868758482778 Nonsignificant None 3 Molecular Function:translation elongation factor activity (GO:0003746),Molecular Function:protein binding (GO:0005515),Biological Process:translational elongation (GO:0006414) elongation factor 1-gamma -- ko05134 Legionellosis Glutathione S-transferase O Posttranslational modification, protein turnover, chaperones ; IPR001662 [Translation elongation factor EF1B, gamma chain, conserved] ; IPR004045[Glutathione S-transferase, N-terminal] ; IPR004046[Glutathione S-transferase, C-terminal] -- -- Q5SX50 Profilin Pfn1 18452.9 17687.5 15134.3 15689.5 15812.8 16859.6 1.06022923003439 0.41540426335802 0.0843762207132736 Nonsignificant None -- -- profilin -- ko04015 Rap1 signaling pathway ko04810 Regulation of actin cytoskeleton ko05132 Salmonella infection Profilin Z Cytoskeleton ; IPR005455 [Profilin] -- -- E9PXX7 Protein disulfide-isomerase Txndc5 9486 9807.9 10795.9 10034.7 10041.2 9933.2 1.00268918428077 0.951893842833133 0.00387446558171519 Nonsignificant None 1 Biological Process:cell redox homeostasis (GO:0045454) thioredoxin domain-containing protein 5 -- ko04141 Protein processing in endoplasmic reticulum Thioredoxin/protein disulfide isomerase O Posttranslational modification, protein turnover, chaperones ; IPR013766 [Thioredoxin domain] -- -- Q60864 Stress-induced-phosphoprotein 1 Stip1 15195.8 14777.6 14483.4 13909.1 14501.3 14148.5 1.04459466762534 0.0782796384781504 0.0629432442716724 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) stress-induced-phosphoprotein 1 -- ko05020 Prion diseases Molecular co-chaperone STI1 O Posttranslational modification, protein turnover, chaperones ; IPR001440 [Tetratricopeptide repeat 1] ; IPR011990[Tetratricopeptide-like helical domain] ; IPR019734[Tetratricopeptide repeat] -- -- P05202 Aspartate aminotransferase, mitochondrial Got2 11067.2 11051.7 13485.2 14191.3 13833 14603.8 0.835226059805621 0.0492306665318779 -0.259761368892149 Nonsignificant None 2 Biological Process:biosynthetic process (GO:0009058),Molecular Function:pyridoxal phosphate binding (GO:0030170) aspartate aminotransferase, mitochondrial 2.6.1.1 ko00220 Arginine biosynthesis ko00250 Alanine, aspartate and glutamate metabolism ko00270 Cysteine and methionine metabolism ko00330 Arginine and proline metabolism ko00350 Tyrosine metabolism ko00360 Phenylalanine metabolism ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis ko01100 Metabolic pathways ko01200 Carbon metabolism ko01210 2-Oxocarboxylic acid metabolism ko01230 Biosynthesis of amino acids ko04975 Fat digestion and absorption Aspartate aminotransferase/Glutamic oxaloacetic transaminase AAT1/GOT2 E Amino acid transport and metabolism ; IPR004839 [Aminotransferase, class I/classII] -- -- Q9CZP6 40S ribosomal protein S3 Rps3 15149.6 16050.1 13018.4 10916.2 11541.6 11748.4 1.29269255281206 0.0232349626485223 0.370379192955368 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) small subunit ribosomal protein S3e -- ko03010 Ribosome 40S ribosomal protein S3 J Translation, ribosomal structure and biogenesis ; IPR004044 [K Homology domain, type 2] -- -- Q6GT24 Peroxiredoxin-6 Prdx6 572.7 540.4 1037.5 1074 736.6 1343.1 0.681929162570948 0.232500297299186 -0.552306212112134 Nonsignificant None 4 Molecular Function:antioxidant activity (GO:0016209),Molecular Function:oxidoreductase activity (GO:0016491),Molecular Function:peroxiredoxin activity (GO:0051920),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko01100 Metabolic pathways Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes O Posttranslational modification, protein turnover, chaperones ; IPR000866 [Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant] ; IPR019479[Peroxiredoxin, C-terminal] -- -- Q9JIK5 Nucleolar RNA helicase 2 Ddx21 9867.3 10105.9 8799.5 7107.2 6992.1 6891 1.37076173280039 0.0210398627337848 0.454977822188785 Nonsignificant None 5 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:RNA binding (GO:0003723),Molecular Function:helicase activity (GO:0004386),Molecular Function:ATP binding (GO:0005524),Cellular Component:nucleus (GO:0005634) ATP-dependent RNA helicase DDX21 3.6.4.13 ATP-dependent RNA helicase A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR011545[DEAD/DEAH box helicase domain] ; IPR012562[GUCT] -- -- Q8K0C9 GDP-mannose 4,6 dehydratase Gmds 12054.5 11083.7 13240.7 14094.7 14211.6 14398.7 0.85186512118019 0.0746693523375041 -0.231303073366567 Nonsignificant None -- -- GDPmannose 4,6-dehydratase 4.2.1.47 ko00051 Fructose and mannose metabolism ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways GDP-mannose 4,6 dehydratase G Carbohydrate transport and metabolism ; IPR016040 [NAD(P)-binding domain] -- -- O08709 Peroxiredoxin-6 Prdx6 475.3 477.6 477 1329 1339.5 555.9 0.443462349584419 0.147603860369013 -1.17311647147401 Nonsignificant None 4 Molecular Function:antioxidant activity (GO:0016209),Molecular Function:oxidoreductase activity (GO:0016491),Molecular Function:peroxiredoxin activity (GO:0051920),Biological Process:oxidation-reduction process (GO:0055114) -- -- -- Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes O Posttranslational modification, protein turnover, chaperones ; IPR000866 [Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant] ; IPR019479[Peroxiredoxin, C-terminal] -- -- Q8BVI9 ADP/ATP translocase Slc25a4 2767 2881 3355.6 3243.4 3083.9 3073.1 0.957789030254032 0.521455247118258 -0.0622201826886175 Nonsignificant None -- -- solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31 -- ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04217 Necroptosis ko04218 Cellular senescence ko05012 Parkinson's disease ko05016 Huntington's disease ko05166 HTLV-I infection Mitochondrial ADP/ATP carrier proteins C Energy production and conversion ; IPR018108 [Mitochondrial substrate/solute carrier] -- -- A0A0R4J0X5 Alpha-1-antitrypsin 1-3 Serpina1c 3026.2 2876.5 2393.4 1556.4 1885.5 1650 1.62927394489287 0.00761027102368951 0.704229197915395 Significant up -- -- alpha-1-antitrypsin -- ko04610 Complement and coagulation cascades Serpin V Defense mechanisms ; IPR023796 [Serpin domain] -- -- Q3UPL0 Protein transport protein Sec31A Sec31a 9074.1 8909.5 10176.3 9245.6 9307.6 8871.7 1.02680046235355 0.591266348945175 0.0381558506510472 Nonsignificant None -- -- protein transport protein SEC31 -- ko04141 Protein processing in endoplasmic reticulum Vesicle coat complex COPII, subunit SEC31 U Intracellular trafficking, secretion, and vesicular transport ; IPR024298 [Ancestral coatomer element 1, Sec16/Sec31] -- -- E9PUD2 Dynamin-1-like protein Dnm1l 7421.1 7420.6 8087.4 8145.2 8113.4 7971.4 0.946310359059018 0.130600212368163 -0.0796146766049181 Nonsignificant None 2 Molecular Function:GTPase activity (GO:0003924),Molecular Function:GTP binding (GO:0005525) dynamin 1-like protein 3.6.5.5 ko04217 Necroptosis ko04621 NOD-like receptor signaling pathway ko04668 TNF signaling pathway Vacuolar sorting protein VPS1, dynamin, and related proteins UR Intracellular trafficking, secretion, and vesicular transport ; General function prediction only ; IPR000375 [Dynamin central domain] ; IPR003130[Dynamin GTPase effector] ; IPR022812[Dynamin superfamily] -- -- Q99LF4 RNA-splicing ligase RtcB homolog Rtcb 6896.8 6724.2 7943.4 7694.1 7773.2 7770.3 0.927996006472269 0.280438852590837 -0.107809497999008 Nonsignificant None 2 Biological Process:RNA processing (GO:0006396),Molecular Function:RNA ligase activity (GO:0008452) tRNA-splicing ligase RtcB 6.5.1.3 -- Uncharacterized conserved protein, contains RtcB domain S Function unknown ; IPR001233 [tRNA-splicing ligase, RtcB] -- -- E9Q1S3 Protein transport protein SEC23 Sec23a 4918 4784.1 4628.8 4816.3 4823.3 4736 0.99689056456774 0.873947353630687 -0.00449295598203378 Nonsignificant None 4 Biological Process:intracellular protein transport (GO:0006886),Biological Process:ER to Golgi vesicle-mediated transport (GO:0006888),Molecular Function:zinc ion binding (GO:0008270),Cellular Component:COPII vesicle coat (GO:0030127) protein transport protein SEC23 -- ko04141 Protein processing in endoplasmic reticulum Vesicle coat complex COPII, subunit SEC23 U Intracellular trafficking, secretion, and vesicular transport ; IPR006895 [Zinc finger, Sec23/Sec24-type] ; IPR006896[Sec23/Sec24, trunk domain] ; IPR006900[Sec23/Sec24, helical domain] ; IPR007123[Gelsolin-like domain] ; IPR012990[Sec23/Sec24 beta-sandwich] -- -- O55029 Coatomer subunit beta Copb2 7681.4 7905.5 8188.8 8253.2 8376.9 8117.3 0.960735269159589 0.120868003232741 -0.0577891441023673 Nonsignificant None 5 Molecular Function:structural molecule activity (GO:0005198),Molecular Function:protein binding (GO:0005515),Biological Process:intracellular protein transport (GO:0006886),Biological Process:vesicle-mediated transport (GO:0016192),Cellular Component:membrane coat (GO:0030117) coatomer subunit beta' -- -- Vesicle coat complex COPI, beta' subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR001680 [WD40 repeat] ; IPR006692[Coatomer, WD associated region] -- -- Q9Z2X1 Heterogeneous nuclear ribonucleoprotein F Hnrnpf 7531.9 7522.5 7414.8 6845 7314.7 6976.8 1.06305206633075 0.037392584488345 0.0882122591433637 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) heterogeneous nuclear ribonucleoprotein F/H -- -- Splicing factor hnRNP-F and related RNA-binding proteins A RNA processing and modification ; IPR000504 [RNA recognition motif domain] ; IPR012996[Zinc finger, CHHC-type] -- -- P54071 Isocitrate dehydrogenase [NADP], mitochondrial Idh2 14930.2 15015.9 15648.9 16472.5 15709.4 16465.8 0.937248831907778 0.0401756363182728 -0.0934959724021709 Nonsignificant None 1 Biological Process:oxidation-reduction process (GO:0055114) isocitrate dehydrogenase 1.1.1.42 ko00020 Citrate cycle (TCA cycle) ko00480 Glutathione metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01210 2-Oxocarboxylic acid metabolism ko01230 Biosynthesis of amino acids ko04146 Peroxisome NADP-dependent isocitrate dehydrogenase C Energy production and conversion ; IPR024084 [Isopropylmalate dehydrogenase-like domain] -- -- Q4FK36 Destrin Dstn 13403 13656.6 12879.1 16222.6 15613.4 15907.3 0.83652994242124 0.000839753230363827 -0.257510914444985 Nonsignificant None 2 Molecular Function:actin binding (GO:0003779),Cellular Component:intracellular (GO:0005622) destrin (actin-depolymerizing factor) -- -- Actin depolymerizing factor Z Cytoskeleton ; IPR002108 [Actin-depolymerising factor homology domain] -- -- P24549 Aldehyde dehydrogenase 1A1 Aldh1a1 3854.8 3848.5 4504.6 4415.9 4054.5 4346 0.95252176898349 0.452861545130659 -0.07017603047495 Nonsignificant None 3 Biological Process:metabolic process (GO:0008152),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) retinal dehydrogenase 1.2.1.36 ko00830 Retinol metabolism ko01100 Metabolic pathways Aldehyde dehydrogenase C Energy production and conversion ; IPR015590 [Aldehyde dehydrogenase domain] -- -- F8WHM5 Golgi apparatus protein 1 (Fragment) Glg1 6954.1 7442.7 7743.4 7471.3 7411.3 7345.6 0.996041064953527 0.910782634669883 -0.00572287168685112 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) golgi apparatus protein 1 -- ko04514 Cell adhesion molecules (CAMs) Golgi apparatus protein (cysteine-rich fibroblast growth factor receptor) U Intracellular trafficking, secretion, and vesicular transport ; IPR001893 [Cysteine-rich Golgi apparatus protein 1 repeat] -- -- P50396 Rab GDP dissociation inhibitor alpha Gdi1 3383.1 3461.3 3678.4 3856.2 3805 4017.5 0.901024942844666 0.0241941965924244 -0.150361050535319 Nonsignificant None 2 Molecular Function:GDP-dissociation inhibitor activity (GO:0005092),Biological Process:small GTPase mediated signal transduction (GO:0007264) Rab GDP dissociation inhibitor -- -- RAB proteins geranylgeranyltransferase component A (RAB escort protein) O Posttranslational modification, protein turnover, chaperones ; IPR018203 [GDP dissociation inhibitor] -- -- P0DP27 Calmodulin-2 Calm2 10694.1 11700.6 6823.2 6836.1 6779 6907.1 1.42372162828547 0.190461077714879 0.509667092405944 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) calmodulin -- ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04070 Phosphatidylinositol signaling system ko04114 Oocyte meiosis ko04218 Cellular senescence ko04261 Adrenergic signaling in cardiomyocytes ko04270 Vascular smooth muscle contraction ko04371 Apelin signaling pathway ko04713 Circadian entrainment ko04720 Long-term potentiation ko04722 Neurotrophin signaling pathway ko04728 Dopaminergic synapse ko04740 Olfactory transduction ko04744 Phototransduction ko04750 Inflammatory mediator regulation of TRP channels ko04910 Insulin signaling pathway ko04912 GnRH signaling pathway ko04915 Estrogen signaling pathway ko04916 Melanogenesis ko04921 Oxytocin signaling pathway ko04922 Glucagon signaling pathway ko04924 Renin secretion ko04925 Aldosterone synthesis and secretion ko04970 Salivary secretion ko04971 Gastric acid secretion ko05010 Alzheimer's disease ko05031 Amphetamine addiction ko05034 Alcoholism ko05133 Pertussis ko05152 Tuberculosis ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05200 Pathways in cancer ko05214 Glioma ko05418 Fluid shear stress and atherosclerosis Calmodulin and related proteins (EF-Hand superfamily) T Signal transduction mechanisms ; IPR002048 [EF-hand domain] -- -- Q3UKT3 Ornithine aminotransferase Oat 6908.9 6903.7 12229 7880.4 7294.8 7322.9 1.15750218907374 0.574741294105953 0.211014921919938 Nonsignificant None 2 Molecular Function:transaminase activity (GO:0008483),Molecular Function:pyridoxal phosphate binding (GO:0030170) ornithine--oxo-acid transaminase 2.6.1.13 ko00330 Arginine and proline metabolism ko01100 Metabolic pathways Ornithine aminotransferase E Amino acid transport and metabolism ; IPR005814 [Aminotransferase class-III] -- -- P97927 Laminin subunit alpha-4 Lama4 6277.9 6446.6 6919.9 6967.8 7024.9 6961.6 0.937487771006428 0.149574642742737 -0.0931282234031614 Nonsignificant None 5 Molecular Function:receptor binding (GO:0005102),Biological Process:cell adhesion (GO:0007155),Biological Process:regulation of cell adhesion (GO:0030155),Biological Process:regulation of cell migration (GO:0030334),Biological Process:regulation of embryonic development (GO:0045995) laminin, alpha 4 -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko05143 African trypanosomiasis ko05145 Toxoplasmosis ko05146 Amoebiasis ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05222 Small cell lung cancer Extracellular matrix glycoprotein Laminin subunits alpha and gamma W Extracellular structures ; IPR001791 [Laminin G domain] ; IPR002049[Laminin EGF domain] ; IPR009254[Laminin alpha, domain I] ; IPR010307[Laminin domain II] -- -- G5E866 Splicing factor 3B subunit 1 Sf3b1 8480.5 8461 7052.7 6375.5 6166.7 6632.2 1.25136640520694 0.0308269000420588 0.323504278374819 Nonsignificant None -- -- splicing factor 3B subunit 1 -- ko03040 Spliceosome Splicing factor 3b, subunit 1 A RNA processing and modification ; IPR015016 [Splicing factor 3B subunit 1] -- -- Q8BZF8 Phosphoglucomutase-like protein 5 Pgm5 8183.4 8750 9127.6 10429.1 9853.9 10377 0.85 0.0097126942072538 -0.234465253637023 Nonsignificant None 1 Biological Process:carbohydrate metabolic process (GO:0005975) phosphoglucomutase-like protein 5 -- -- Phosphoglucomutase G Carbohydrate transport and metabolism ; IPR005844 [Alpha-D-phosphohexomutase, alpha/beta/alpha domain I] ; IPR005845[Alpha-D-phosphohexomutase, alpha/beta/alpha domain II] ; IPR005846[Alpha-D-phosphohexomutase, alpha/beta/alpha domain III] -- -- Q8R059 UDP-glucose 4-epimerase Gale 4823.7 4511.8 4736.2 5587.8 5631 5430.2 0.845197909784371 0.00150805705264749 -0.242638895465255 Nonsignificant None -- -- UDP-glucose 4-epimerase 5.1.3.2 ko00052 Galactose metabolism ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways UDP-glucose 4-epimerase/UDP-sulfoquinovose synthase M Cell wall/membrane/envelope biogenesis ; IPR016040 [NAD(P)-binding domain] -- -- Q1MWP9 EH-domain containing 4 (Fragment) Ehd4 6964.9 6854.5 7120 7626.8 7439.2 7641.3 0.922143980129738 0.00427314464150537 -0.116936069610139 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) EH domain-containing protein 4 -- ko04144 Endocytosis Endocytosis/signaling protein EHD1 TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR000261 [EH domain] ; IPR022812[Dynamin superfamily] ; IPR031692[EH domain-containing protein, N-terminal] -- -- P46460 Vesicle-fusing ATPase Nsf 6888.9 6755.4 6701.2 6470.3 6684.3 6406.2 1.04011594617807 0.0605261657632761 0.0567443607243837 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) vesicle-fusing ATPase 3.6.4.6 ko04721 Synaptic vesicle cycle ko04727 GABAergic synapse ko04962 Vasopressin-regulated water reabsorption AAA+-type ATPase O Posttranslational modification, protein turnover, chaperones ; IPR003338 [CDC48, N-terminal subdomain] ; IPR003959[ATPase, AAA-type, core] ; IPR004201[CDC48, domain 2] -- -- Q8K144 Polypyrimidine tract-binding protein 1 Ptbp1 113.5 101.8 110.2 96.1 94.4 88.5 1.16666666666667 0.020612825524454 0.222392421336448 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) polypyrimidine tract-binding protein 1 -- -- Polypyrimidine tract-binding protein A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- Q3TGW0 Actin-related protein 3 Actr3 8079.4 8223.2 7817.8 7683.2 7816.6 7794.5 1.03546361126971 0.0935118060267711 0.0502768546079906 Nonsignificant None -- -- actin-related protein 3 -- ko04530 Tight junction Actin-related protein Arp2/3 complex, subunit Arp3 Z Cytoskeleton ; IPR004000 [Actin family] -- -- Q05CR3 Plec1 protein (Fragment) Plec 450.1 427.2 403.9 357.4 345.2 343.5 1.22473950865118 0.00504785296006039 0.292474933276823 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) plectin -- -- Dystonin, GAS (Growth-arrest-specific protein), and related proteins Z Cytoskeleton ; IPR001715 [Calponin homology domain] -- -- Q99KK7 Dipeptidyl peptidase 3 Dpp3 7540.5 7305.2 7870.3 7715.1 7982 7562.4 0.976633203637224 0.426091581314838 -0.0341112672412376 Nonsignificant None -- -- dipeptidyl-peptidase III 3.4.14.4 -- Dipeptidyl peptidase III R General function prediction only ; -- -- -- Q9CZD3 Glycine--tRNA ligase Gars1 11232.9 10832 10354.6 9661.9 9898.1 9803.5 1.10407478672502 0.0179387698463494 0.142837899274595 Nonsignificant None 4 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation for protein translation (GO:0006418) glycyl-tRNA synthetase 6.1.1.14 ko00970 Aminoacyl-tRNA biosynthesis Glycyl-tRNA synthetase and related class II tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR000738 [WHEP-TRS domain] ; IPR002314[Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)] ; IPR004154[Anticodon-binding] -- -- O88685 26S proteasome regulatory subunit 6A Psmc3 7513.2 7590.4 7444.2 6396.7 6726.4 6347.1 1.15806720013148 0.00124948103218166 0.211718972224822 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) 26S proteasome regulatory subunit T5 -- ko03050 Proteasome ko05169 Epstein-Barr virus infection 26S proteasome regulatory complex, ATPase RPT5 O Posttranslational modification, protein turnover, chaperones ; IPR003959 [ATPase, AAA-type, core] -- -- Q3THE2 Myosin regulatory light chain 12B Myl12b 431.7 426.9 450.3 496.2 498.5 446.6 0.908138486088948 0.0741798029543295 -0.139015777592202 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) myosin regulatory light chain 12 -- ko04510 Focal adhesion ko04530 Tight junction ko04611 Platelet activation ko04670 Leukocyte transendothelial migration ko04810 Regulation of actin cytoskeleton Myosin regulatory light chain, EF-Hand protein superfamily Z Cytoskeleton ; IPR002048 [EF-hand domain] ; IPR015070[DJBP, EF-hand domain] -- -- Q9CPY7 Cytosol aminopeptidase Lap3 6671.6 6764.3 7882.1 7383.6 7896.3 7207.7 0.947989114000605 0.426040436668461 -0.0770576025017135 Nonsignificant None 3 Molecular Function:aminopeptidase activity (GO:0004177),Cellular Component:intracellular (GO:0005622),Biological Process:proteolysis (GO:0006508) -- -- ko00330 Arginine and proline metabolism ko00480 Glutathione metabolism ko01100 Metabolic pathways Predicted aminopeptidase of the M17 family R General function prediction only ; IPR000819 [Peptidase M17, leucyl aminopeptidase, C-terminal] ; IPR008283[Peptidase M17, leucyl aminopeptidase, N-terminal] -- -- Q3TXE5 Uncharacterized protein Canx 14896.3 14750.4 17807.9 15652.3 15507.6 15059.4 1.02672693009197 0.704817712649946 0.0380525312314352 Nonsignificant None 4 Molecular Function:calcium ion binding (GO:0005509),Cellular Component:endoplasmic reticulum (GO:0005783),Biological Process:protein folding (GO:0006457),Molecular Function:unfolded protein binding (GO:0051082) calnexin -- ko04141 Protein processing in endoplasmic reticulum ko04145 Phagosome ko04612 Antigen processing and presentation ko04918 Thyroid hormone synthesis ko05166 HTLV-I infection Calnexin O Posttranslational modification, protein turnover, chaperones ; IPR001580 [Calreticulin/calnexin] -- -- E9PWE8 Dihydropyrimidinase-related protein 3 Dpysl3 5855.3 6123.4 6721 6433.9 6190.2 6245.5 0.99099609954636 0.841978594786651 -0.0130487157563226 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) -- -- -- Dihydroorotase and related enzymes F Nucleotide transport and metabolism ; IPR006680 [Amidohydrolase-related] -- -- Q3TPD9 Amine oxidase (Fragment) Maoa 6603.8 6374.2 7634 11325.7 10716.7 11400.4 0.616335952731231 0.00064829001936542 -0.698211144582087 Significant down 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) monoamine oxidase 1.4.3.4 ko00260 Glycine, serine and threonine metabolism ko00330 Arginine and proline metabolism ko00340 Histidine metabolism ko00350 Tyrosine metabolism ko00360 Phenylalanine metabolism ko00380 Tryptophan metabolism ko00982 Drug metabolism - cytochrome P450 ko01100 Metabolic pathways ko04726 Serotonergic synapse ko04728 Dopaminergic synapse ko05030 Cocaine addiction ko05031 Amphetamine addiction ko05034 Alcoholism Amine oxidase Q Secondary metabolites biosynthesis, transport and catabolism ; IPR002937 [Amine oxidase] -- -- P68254 14-3-3 protein theta Ywhaq 6320.2 6358.4 6503.1 7055.5 6908 7173.9 0.907476794686196 0.00235827402052403 -0.140067342819396 Nonsignificant None -- -- 14-3-3 protein beta/theta/zeta -- ko04110 Cell cycle ko04114 Oocyte meiosis ko04151 PI3K-Akt signaling pathway ko04390 Hippo signaling pathway ko05161 Hepatitis B ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis Multifunctional chaperone (14-3-3 family) O Posttranslational modification, protein turnover, chaperones ; IPR023410 [14-3-3 domain] -- -- Q08189 Protein-glutamine gamma-glutamyltransferase E Tgm3 5076.6 4301.6 4387 18807.6 16669.4 18980.9 0.252767734341574 0.0000650836940616594 -1.98411577882601 Significant down 2 Molecular Function:protein-glutamine gamma-glutamyltransferase activity (GO:0003810),Biological Process:peptide cross-linking (GO:0018149) transglutaminase 3 2.3.2.13 -- -- -- -- IPR001102 [Transglutaminase, N-terminal] ; IPR002931[Transglutaminase-like] ; IPR008958[Transglutaminase, C-terminal] -- -- Q4FJZ4 Tryptophan--tRNA ligase, cytoplasmic Wars 10031.5 9527.7 9286.1 8829.4 8895.1 8830.7 1.08623922998132 0.0723279014159743 0.11934187284675 Nonsignificant None 4 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation for protein translation (GO:0006418) tryptophanyl-tRNA synthetase 6.1.1.2 ko00970 Aminoacyl-tRNA biosynthesis Cytoplasmic tryptophanyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR000738 [WHEP-TRS domain] ; IPR002305[Aminoacyl-tRNA synthetase, class Ic] -- -- Q3U7Z6 Phosphoglycerate mutase Pgam1 8046.5 7242.4 5498.4 4920.5 4968.1 5705.7 1.33300629076009 0.094692509102655 0.414683588849214 Nonsignificant None -- -- 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 5.4.2.11 ko00010 Glycolysis / Gluconeogenesis ko00260 Glycine, serine and threonine metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids ko04922 Glucagon signaling pathway ko05230 Central carbon metabolism in cancer Phosphoglycerate mutase G Carbohydrate transport and metabolism ; IPR013078 [Histidine phosphatase superfamily, clade-1] -- -- P97351 40S ribosomal protein S3a Rps3a 15948 15597.5 13728.6 12018.3 12082.9 12698.9 1.23027111339371 0.0173759766600095 0.298976275604027 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S3Ae -- ko03010 Ribosome 40S ribosomal protein S3A J Translation, ribosomal structure and biogenesis ; IPR001593 [Ribosomal protein S3Ae] -- -- P10649 Glutathione S-transferase Mu 1 Gstm1 5107.5 4793.7 4463.7 6704.6 6592.8 7370.3 0.695041054398893 0.00234788749397179 -0.52482989801755 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) glutathione S-transferase 2.5.1.18 ko00480 Glutathione metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko01524 Platinum drug resistance ko05200 Pathways in cancer ko05204 Chemical carcinogenesis ko05225 Hepatocellular carcinoma ko05418 Fluid shear stress and atherosclerosis Glutathione S-transferase O Posttranslational modification, protein turnover, chaperones ; IPR004045 [Glutathione S-transferase, N-terminal] ; IPR004046[Glutathione S-transferase, C-terminal] -- -- Q91X72 Hemopexin Hpx 16985.2 17926.2 12175.7 6495.6 7085 7365.5 2.24801275655134 0.0369679408596836 1.16865022228532 Significant up -- -- hemopexin -- -- Gelatinase A and related matrix metalloproteases OW Posttranslational modification, protein turnover, chaperones ; Extracellular structures ; IPR018487 [Hemopexin-like repeats] -- -- A8DUL0 Beta-globin Hbbt1 5546.1 5611 5548.4 5141.3 9045 5876.8 0.832647995573964 0.448697197821107 -0.264221374049335 Nonsignificant None 2 Molecular Function:oxygen binding (GO:0019825),Molecular Function:heme binding (GO:0020037) hemoglobin subunit beta -- ko05143 African trypanosomiasis ko05144 Malaria Globins and related hemoproteins C Energy production and conversion ; IPR000971 [Globin] -- -- Q3TML0 Protein disulfide-isomerase A6 Pdia6 8352.1 8246.7 9769.1 9188 8892.3 8340.1 0.998012899123405 0.976147957535318 -0.00286963265037223 Nonsignificant None 1 Biological Process:cell redox homeostasis (GO:0045454) protein disulfide-isomerase A6 5.3.4.1 ko04141 Protein processing in endoplasmic reticulum Thioredoxin/protein disulfide isomerase O Posttranslational modification, protein turnover, chaperones ; IPR013766 [Thioredoxin domain] -- -- E9Q6R7 Utrophin Utrn 4379.7 4462.9 4615.9 4540.1 4622.9 4575.4 0.97962644849473 0.27153012093604 -0.0296963697838706 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:zinc ion binding (GO:0008270) -- -- -- Dystrophin-like protein NTZ Cell motility ; Signal transduction mechanisms ; Cytoskeleton ; IPR000433 [Zinc finger, ZZ-type] ; IPR001715[Calponin homology domain] ; IPR002017[Spectrin repeat] ; IPR015153[EF-hand domain, type 1] ; IPR015154[EF-hand domain, type 2] -- -- Q8BFW7 Lipoma-preferred partner homolog Lpp 7388.9 7781 6192.7 7640.6 7498.5 7742 0.933635183623165 0.400576916097414 -0.099069165502096 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) lipoma-prefererred partner -- Focal adhesion adaptor protein Paxillin and related LIM proteins T Signal transduction mechanisms ; IPR001781 [Zinc finger, LIM-type] -- -- Q9CVB6 Actin-related protein 2/3 complex subunit 2 Arpc2 11741.5 12546.4 11269.6 11015.9 11385.5 11620.4 1.04513870518315 0.282098779514108 0.0636944217325423 Nonsignificant None 4 Cellular Component:Arp2/3 protein complex (GO:0005885),Cellular Component:actin cytoskeleton (GO:0015629),Biological Process:regulation of actin filament polymerization (GO:0030833),Biological Process:Arp2/3 complex-mediated actin nucleation (GO:0034314) actin related protein 2/3 complex, subunit 2 -- ko04144 Endocytosis ko04666 Fc gamma R-mediated phagocytosis ko04810 Regulation of actin cytoskeleton ko05100 Bacterial invasion of epithelial cells ko05132 Salmonella infection Actin-related protein Arp2/3 complex, subunit ARPC2 Z Cytoskeleton ; IPR007188 [Actin-related protein 2/3 complex subunit 2] -- -- Q4FJQ6 Serpinb6a protein Serpinb6a 8555 9284.7 6771 12866.4 12102.6 13379.2 0.641769365967633 0.00535325801762396 -0.63987316880982 Significant down -- -- serpin B -- ko05146 Amoebiasis Serpin V Defense mechanisms ; IPR023796 [Serpin domain] -- -- Q00897 Alpha-1-antitrypsin 1-4 Serpina1d 372 366.8 358.6 364.5 436.1 332.7 0.968322597723463 0.734238208468585 -0.0464403318902973 Nonsignificant None -- -- alpha-1-antitrypsin -- ko04610 Complement and coagulation cascades Serpin V Defense mechanisms ; IPR023796 [Serpin domain] -- -- Q3TZN6 Uncharacterized protein (Fragment) Sptbn1 33.3 32.8 42 38.1 33.3 33.4 1.03148854961832 0.761202233097597 0.0447278061971999 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) spectrin beta -- -- Beta-spectrin Z Cytoskeleton ; IPR001715 [Calponin homology domain] ; IPR002017[Spectrin repeat] -- -- Q99J77 Sialic acid synthase Nans 10645.5 9614.4 8605.6 13388 13074.5 14359 0.70711512315814 0.00481168088744675 -0.499982980151827 Nonsignificant None 1 Biological Process:carbohydrate biosynthetic process (GO:0016051) -- -- ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways -- -- -- IPR013132 [N-acetylneuraminic acid synthase, N-terminal] ; IPR013974[SAF domain] -- -- P26043 Radixin Rdx 3596.5 3740.2 3411.6 3699.1 3623.2 3818.4 0.964777796727315 0.303138937626373 -0.0517313892662672 Nonsignificant None 3 Cellular Component:cytoplasm (GO:0005737),Molecular Function:cytoskeletal protein binding (GO:0008092),Cellular Component:extrinsic component of membrane (GO:0019898) radixin -- ko04530 Tight junction ko04810 Regulation of actin cytoskeleton ko05205 Proteoglycans in cancer ko05206 MicroRNAs in cancer Radixin, moesin and related proteins of the ERM family R General function prediction only ; IPR011259 [Ezrin/radixin/moesin, C-terminal] ; IPR018979[FERM, N-terminal] ; IPR018980[FERM, C-terminal PH-like domain] ; IPR019748[FERM central domain] -- -- P62141 Serine/threonine-protein phosphatase PP1-beta catalytic subunit Ppp1cb 2627.6 2606.1 2441.2 2949.1 2901.9 2934 0.873636881047239 0.00361853705747117 -0.194894333202817 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) serine/threonine-protein phosphatase PP1 catalytic subunit 3.1.3.16 ko03015 mRNA surveillance pathway ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04114 Oocyte meiosis ko04218 Cellular senescence ko04261 Adrenergic signaling in cardiomyocytes ko04270 Vascular smooth muscle contraction ko04390 Hippo signaling pathway ko04510 Focal adhesion ko04611 Platelet activation ko04720 Long-term potentiation ko04728 Dopaminergic synapse ko04750 Inflammatory mediator regulation of TRP channels ko04810 Regulation of actin cytoskeleton ko04910 Insulin signaling pathway ko04921 Oxytocin signaling pathway ko04931 Insulin resistance ko05031 Amphetamine addiction ko05034 Alcoholism ko05168 Herpes simplex infection ko05205 Proteoglycans in cancer Serine/threonine specific protein phosphatase PP1, catalytic subunit TR Signal transduction mechanisms ; General function prediction only ; IPR004843 [Calcineurin-like phosphoesterase domain, ApaH type] ; IPR031675[Serine-threonine protein phosphatase, N-terminal] -- -- P30416 Peptidyl-prolyl cis-trans isomerase FKBP4 Fkbp4 14718.8 14043.6 11700.1 11235.5 11173 10911 1.21437896727142 0.119658712691885 0.28021870897867 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) FK506-binding protein 4/5 5.2.1.8 ko04915 Estrogen signaling pathway FKBP-type peptidyl-prolyl cis-trans isomerase O Posttranslational modification, protein turnover, chaperones ; IPR001179 [FKBP-type peptidyl-prolyl cis-trans isomerase domain] ; IPR001440[Tetratricopeptide repeat 1] ; IPR013105[Tetratricopeptide repeat 2] -- -- P35700 Peroxiredoxin-1 Prdx1 14815.4 14514.7 15631 15055.3 14838.7 15536.4 0.989669912657604 0.710280296057954 -0.0149806755333196 Nonsignificant None 4 Molecular Function:antioxidant activity (GO:0016209),Molecular Function:oxidoreductase activity (GO:0016491),Molecular Function:peroxiredoxin activity (GO:0051920),Biological Process:oxidation-reduction process (GO:0055114) peroxiredoxin 1 1.11.1.15 ko04146 Peroxisome Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes O Posttranslational modification, protein turnover, chaperones ; IPR000866 [Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant] ; IPR019479[Peroxiredoxin, C-terminal] -- -- Q9WUB3 Glycogen phosphorylase, muscle form Pygm 2170.3 2212.3 2378 2321.8 2312.4 2413.2 0.959304140534098 0.249876912822543 -0.0599398109509777 Nonsignificant None 2 Biological Process:carbohydrate metabolic process (GO:0005975),Molecular Function:glycogen phosphorylase activity (GO:0008184) glycogen phosphorylase 2.4.1.1 ko00500 Starch and sucrose metabolism ko01100 Metabolic pathways ko04217 Necroptosis ko04910 Insulin signaling pathway ko04922 Glucagon signaling pathway ko04931 Insulin resistance Glycogen phosphorylase G Carbohydrate transport and metabolism ; IPR000811 [Glycosyl transferase, family 35] -- -- Q6A0A9 Constitutive coactivator of PPAR-gamma-like protein 1 FAM120A 6547.8 6394.6 6461.4 6306.7 6509.5 6265.5 1.01688004737523 0.287005306540311 0.0241495068616851 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q11011 Puromycin-sensitive aminopeptidase Npepps 9559.8 9315.1 9952.4 9249.5 9606.4 9575.9 1.01391048051829 0.577889672201749 0.0199302805330339 Nonsignificant None 2 Molecular Function:metallopeptidase activity (GO:0008237),Molecular Function:zinc ion binding (GO:0008270) puromycin-sensitive aminopeptidase 3.4.11.- -- Puromycin-sensitive aminopeptidase and related aminopeptidases EO Amino acid transport and metabolism ; Posttranslational modification, protein turnover, chaperones ; IPR014782 [Peptidase M1, membrane alanine aminopeptidase, N-terminal] ; IPR024571[ERAP1-like C-terminal domain] -- -- E9Q0U7 Heat shock protein 105 kDa Hsph1 7248 7269.2 6601.5 6504.3 6578.1 6271.3 1.09119703209205 0.068665897763293 0.125911625545198 Nonsignificant None -- -- heat shock protein 110kDa -- ko04141 Protein processing in endoplasmic reticulum Molecular chaperones HSP105/HSP110/SSE1, HSP70 superfamily O Posttranslational modification, protein turnover, chaperones ; IPR013126 [Heat shock protein 70 family] -- -- Q8CHH7 MKIAA0219 protein (Fragment) Gcn1 557.4 514.8 456.9 626.7 476.4 626.9 0.883872832369942 0.312383547447834 -0.178089278784916 Nonsignificant None -- -- -- -- -- Protein containing adaptin N-terminal region J Translation, ribosomal structure and biogenesis ; -- -- -- Q9CZU6 Citrate synthase, mitochondrial Cs 10617 10038.2 9990.3 11525.8 11262.3 10933.7 0.908774146101335 0.0178598043944344 -0.138006302982657 Nonsignificant None -- -- citrate synthase 2.3.3.1 ko00020 Citrate cycle (TCA cycle) ko00630 Glyoxylate and dicarboxylate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01210 2-Oxocarboxylic acid metabolism ko01230 Biosynthesis of amino acids Citrate synthase C Energy production and conversion ; IPR002020 [Citrate synthase] -- -- Q8BMJ2 Leucine--tRNA ligase, cytoplasmic Lars1 5630.7 5489.4 5901.2 5377.4 5616.5 5483.6 1.03300257927477 0.262794048593084 0.0468438564316967 Nonsignificant None 4 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation for protein translation (GO:0006418) leucyl-tRNA synthetase 6.1.1.4 ko00970 Aminoacyl-tRNA biosynthesis Leucyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR002300 [Aminoacyl-tRNA synthetase, class Ia] ; IPR013155[Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding] -- -- G3X925 Pyruvate kinase Pklr 4365.6 3967.7 4657.1 4706.6 4754.6 4442.6 0.934305729368949 0.242306611077554 -0.098033379994152 Nonsignificant None 4 Molecular Function:magnesium ion binding (GO:0000287),Molecular Function:pyruvate kinase activity (GO:0004743),Biological Process:glycolytic process (GO:0006096),Molecular Function:potassium ion binding (GO:0030955) pyruvate kinase isozymes R/L 2.7.1.40 ko00010 Glycolysis / Gluconeogenesis ko00230 Purine metabolism ko00620 Pyruvate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids ko04910 Insulin signaling pathway ko04930 Type II diabetes mellitus ko04932 Non-alcoholic fatty liver disease (NAFLD) ko04950 Maturity onset diabetes of the young Pyruvate kinase G Carbohydrate transport and metabolism ; IPR015793 [Pyruvate kinase, barrel] ; IPR015795[Pyruvate kinase, C-terminal] -- -- Q9D646 Keratin, type I cuticular Ha4 Krt34 794.6 612.8 575.6 325.8 282.6 402.3 1.96200653012763 0.0131080918717442 0.972329843273297 Significant up 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) type I keratin, acidic -- -- -- -- -- IPR001664 [Intermediate filament protein] -- -- O70209 PDZ and LIM domain protein 3 Pdlim3 7047.8 7251 7159 7398.2 6817.3 7108.9 1.00625574459305 0.81471669582816 0.00899701942327565 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:zinc ion binding (GO:0008270) -- -- -- Adaptor protein Enigma and related PDZ-LIM proteins TZ Signal transduction mechanisms ; Cytoskeleton ; IPR001478 [PDZ domain] ; IPR001781[Zinc finger, LIM-type] ; IPR031847[Domain of unknown function DUF4749] -- -- Q8K0Y2 Keratin, type I cuticular Ha3-I Krt33a 585.6 494.6 469.6 320.8 285.9 394 1.54871589887079 0.0182590264499624 0.631072516056508 Significant up 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) type I keratin, acidic -- -- -- -- -- IPR001664 [Intermediate filament protein] -- -- A0A0R4J0Q5 Lamin-B2 Lmnb2 5419 5083.5 5157.4 5612.7 5481.3 5906.4 0.921148914143197 0.0506825843250345 -0.118493691741761 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) lamin B -- ko04210 Apoptosis Nuclear envelope protein lamin, intermediate filament superfamily DY Cell cycle control, cell division, chromosome partitioning ; Nuclear structure ; IPR001322 [Lamin Tail Domain] ; IPR001664[Intermediate filament protein] -- -- Q9CQV8 14-3-3 protein beta/alpha Ywhab 3980.2 3809.1 3960.9 3607.5 3640.7 4244.8 1.02237883929348 0.709265026087926 0.0319298814970332 Nonsignificant None -- -- 14-3-3 protein beta/theta/zeta -- ko04110 Cell cycle ko04114 Oocyte meiosis ko04151 PI3K-Akt signaling pathway ko04390 Hippo signaling pathway ko05161 Hepatitis B ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis Multifunctional chaperone (14-3-3 family) O Posttranslational modification, protein turnover, chaperones ; IPR023410 [14-3-3 domain] -- -- A1L353 Transforming growth factor-beta-induced protein ig-h3 Tgfbi 9705.1 10426.4 10008.2 9422.9 9160.4 9233.2 1.08351877482789 0.0256169394706255 0.11572415215463 Nonsignificant None -- -- transforming growth factor-beta-induced protein -- -- Fasciclin and related adhesion glycoproteins MW Cell wall/membrane/envelope biogenesis ; Extracellular structures ; IPR000782 [FAS1 domain] -- -- Q8BVQ9 26S proteasome regulatory subunit 7 Psmc2 7206.4 7290.8 7587.3 7185.9 7450.6 6777.6 1.03130647563988 0.381167760265773 0.0444731253169049 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) 26S proteasome regulatory subunit T1 -- ko03050 Proteasome ko05169 Epstein-Barr virus infection 26S proteasome regulatory complex, ATPase RPT1 O Posttranslational modification, protein turnover, chaperones ; IPR003959 [ATPase, AAA-type, core] -- -- Q3V3R4 Integrin alpha-1 Itga1 7562.3 7853.8 8684.4 9215.9 8694.5 9110.8 0.891910795967611 0.0589540864955814 -0.16502866798235 Nonsignificant None -- -- integrin alpha 1 -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04640 Hematopoietic cell lineage ko04810 Regulation of actin cytoskeleton ko05165 Human papillomavirus infection ko05410 Hypertrophic cardiomyopathy (HCM) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05414 Dilated cardiomyopathy (DCM) Vitronectin receptor, alpha subunit W Extracellular structures ; IPR002035 [von Willebrand factor, type A] ; IPR013517[FG-GAP repeat] ; IPR013649[Integrin alpha-2] -- -- B1AXN9 Non-specific serine/threonine protein kinase Rps6ka3 4118.5 4231.6 4287 4490.2 4420.3 4409.8 0.948709863891954 0.0149336343872947 -0.075961147707208 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) ribosomal protein S6 kinase alpha-1/2/3/6 2.7.11.1 ko04010 MAPK signaling pathway ko04114 Oocyte meiosis ko04150 mTOR signaling pathway ko04720 Long-term potentiation ko04722 Neurotrophin signaling pathway ko04914 Progesterone-mediated oocyte maturation ko04931 Insulin resistance Ribosomal protein S6 kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR017892[Protein kinase, C-terminal] -- -- A0A286YDF5 Myoferlin Myof 5582.2 5511.4 5017.3 6274.9 6306.9 6392.8 0.84907718739789 0.00621220000197676 -0.236032383494945 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:integral component of membrane (GO:0016021) myoferlin -- -- Membrane-associated protein FER-1 and related ferlins, contain multiple C2 domains M Cell wall/membrane/envelope biogenesis ; IPR000008 [C2 domain] ; IPR012560[Ferlin A-domain] ; IPR012561[Ferlin B-domain] ; IPR012968[FerIin domain] ; IPR032362[Ferlin, C-terminal domain] -- -- Q99JY0 Trifunctional enzyme subunit beta, mitochondrial Hadhb 11201.8 10399.9 12756.5 12834 11856.2 13049 0.910411455462755 0.223517533259515 -0.135409384084551 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) acetyl-CoA acyltransferase 2.3.1.16 ko00062 Fatty acid elongation ko00071 Fatty acid degradation ko00280 Valine, leucine and isoleucine degradation ko01100 Metabolic pathways ko01212 Fatty acid metabolism Acetyl-CoA acetyltransferase I Lipid transport and metabolism ; IPR020616 [Thiolase, N-terminal] ; IPR020617[Thiolase, C-terminal] -- -- Q8K4Z5 Splicing factor 3A subunit 1 Sf3a1 6918.1 7070.2 5854.7 5173.7 5264.5 5211.6 1.26793952638372 0.0666892603361633 0.342485938642287 Nonsignificant None 3 Molecular Function:RNA binding (GO:0003723),Molecular Function:protein binding (GO:0005515),Biological Process:RNA processing (GO:0006396) splicing factor 3A subunit 1 -- ko03040 Spliceosome Splicing factor 3a, subunit 1 A RNA processing and modification ; IPR000061 [SWAP/Surp] ; IPR000626[Ubiquitin domain] ; IPR022030[Splicing factor 3A subunit 1] -- -- Q61765 Keratin, type I cuticular Ha1 Krt31 347.2 285.9 109.4 79.4 79.7 91.4 2.96407185628743 0.147660351415763 1.56758042249292 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) type I keratin, acidic -- -- -- -- -- IPR001664 [Intermediate filament protein] -- -- Q62351 Transferrin receptor protein 1 Tfrc 11445.4 11300.2 9327.6 5566.7 6279.3 6157.3 1.78151783284176 0.00283178979836347 0.833106924797961 Significant up -- -- transferrin receptor -- ko04066 HIF-1 signaling pathway ko04144 Endocytosis ko04145 Phagosome ko04216 Ferroptosis ko04640 Hematopoietic cell lineage Transferrin receptor and related proteins containing the protease-associated (PA) domain OPR Posttranslational modification, protein turnover, chaperones ; Inorganic ion transport and metabolism ; General function prediction only ; IPR003137 [PA domain] ; IPR007365[Transferrin receptor-like, dimerisation domain] ; IPR007484[Peptidase M28] -- -- Q3UDG8 Calpain-1 catalytic subunit Capn1 5183.3 5144.5 6218.2 5388.6 5157.6 5399.9 1.03762048400549 0.608529961087632 0.0532788656982422 Nonsignificant None 4 Molecular Function:calcium-dependent cysteine-type endopeptidase activity (GO:0004198),Molecular Function:calcium ion binding (GO:0005509),Cellular Component:intracellular (GO:0005622),Biological Process:proteolysis (GO:0006508) calpain-1 3.4.22.52 ko04141 Protein processing in endoplasmic reticulum ko04210 Apoptosis ko04217 Necroptosis ko04218 Cellular senescence ko05010 Alzheimer's disease Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) OT Posttranslational modification, protein turnover, chaperones ; Signal transduction mechanisms ; IPR001300 [Peptidase C2, calpain, catalytic domain] ; IPR002048[EF-hand domain] ; IPR022682[Peptidase C2, calpain, large subunit, domain III] -- -- P37040 NADPH--cytochrome P450 reductase Por 6912.8 7090.3 8042.9 7925.6 7641.1 7446.2 0.957984434816994 0.441320179075834 -0.0619258794214827 Nonsignificant None 3 Molecular Function:FMN binding (GO:0010181),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) NADPH-ferrihemoprotein reductase 1.6.2.4 -- NADP/FAD dependent oxidoreductase C Energy production and conversion ; IPR001433 [Oxidoreductase FAD/NAD(P)-binding] ; IPR003097[FAD-binding, type 1] ; IPR008254[Flavodoxin/nitric oxide synthase] -- -- Q571M4 MKIAA4014 protein (Fragment) Akr1c13 1145.9 1103.7 1421.3 1753 1661.7 1750.4 0.710712280497958 0.00871868277564715 -0.492662466841144 Nonsignificant None -- -- aldo-keto reductase family 1 member C13 1.1.1.218 -- Aldo/keto reductase family proteins R General function prediction only ; IPR023210 [NADP-dependent oxidoreductase domain] -- -- Q3UMT7 Uncharacterized protein Hnrnpl 11419.5 11900.1 12759.6 12224.7 11985.4 11807.3 1.00171583734528 0.962355463148353 0.00247330873754828 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) heterogeneous nuclear ribonucleoprotein L -- -- Heterogeneous nuclear ribonucleoprotein L (contains RRM repeats) A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- Q8VIJ6 Splicing factor, proline- and glutamine-rich Sfpq 10739.8 11156.2 11217.9 10381.3 10384.4 9979.8 1.07703241124717 0.0172716072434567 0.107061665705696 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) splicing factor, proline- and glutamine-rich -- -- RNA-binding protein p54nrb (RRM superfamily) A RNA processing and modification ; IPR000504 [RNA recognition motif domain] ; IPR012975[NOPS] -- -- Q5FB19 Heterogeneous nuclear ribonucleoprotein A3 Hnrnpa3 720.8 710 549.2 592.7 601.9 593.8 1.10713486915679 0.368729054050981 0.146830979311693 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) heterogeneous nuclear ribonucleoprotein A1/A3 -- ko03040 Spliceosome FOG: RRM domain R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- Q9DB77 Cytochrome b-c1 complex subunit 2, mitochondrial Uqcrc2 9724.2 9223.2 10912.9 11554.7 11271.1 12053.7 0.856098854628077 0.0384970322488511 -0.224150699140255 Nonsignificant None -- -- ubiquinol-cytochrome c reductase core subunit 2 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04260 Cardiac muscle contraction ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Ubiquinol cytochrome c reductase, subunit QCR2 C Energy production and conversion ; IPR007863 [Peptidase M16, C-terminal] ; IPR011765[Peptidase M16, N-terminal] -- -- Q3V0K9 Plastin-1 Pls1 8394 7524.3 8770.4 8214 8215.5 7781 1.01975176059974 0.708094748435043 0.0282179979432047 Nonsignificant None 2 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:protein binding (GO:0005515) plastin-1 -- -- Ca2+-binding actin-bundling protein (fimbrin/plastin), EF-Hand protein superfamily Z Cytoskeleton ; IPR001715 [Calponin homology domain] ; IPR002048[EF-hand domain] -- -- Q3U505 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (Fragment) Rpn2 4194.8 4021.3 4868.9 4675 4835.2 4547.4 0.93081322558616 0.298547753106936 -0.103436385270002 Nonsignificant None 3 Biological Process:protein N-linked glycosylation (GO:0006487),Cellular Component:oligosaccharyltransferase complex (GO:0008250),Cellular Component:integral component of membrane (GO:0016021) oligosaccharyltransferase complex subunit delta (ribophorin II) -- ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways ko04141 Protein processing in endoplasmic reticulum Oligosaccharyltransferase, delta subunit (ribophorin II) O Posttranslational modification, protein turnover, chaperones ; IPR008814 [Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit Swp1] -- -- A0A3B2WBH9 Tight junction protein ZO-2 Tjp2 7922 7715.7 7920.3 7526 7746.3 7624.5 1.02887739771496 0.0779834682720626 0.0410710791738781 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) tight junction protein 2 -- ko04530 Tight junction Tight junction proteins T Signal transduction mechanisms ; IPR001478 [PDZ domain] ; IPR008145[Guanylate kinase/L-type calcium channel beta subunit] ; IPR011511[Variant SH3 domain] -- -- Q9ET54 Palladin Palld 2868.6 3096.7 3132.5 3318.5 3058.7 2966.1 0.973724487065598 0.574399214738661 -0.038414471832325 Nonsignificant None -- -- palladin -- -- -- -- -- IPR013098 [Immunoglobulin I-set] -- -- P62814 V-type proton ATPase subunit B, brain isoform Atp6v1b2 3804.2 3687.5 4072.4 4060 4088.4 4124.9 0.942216029918604 0.11005524231904 -0.0858702181061613 Nonsignificant None 3 Molecular Function:ATP binding (GO:0005524),Biological Process:proton transport (GO:0015992),Biological Process:ATP metabolic process (GO:0046034) V-type H+-transporting ATPase subunit B -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04145 Phagosome ko04150 mTOR signaling pathway ko04721 Synaptic vesicle cycle ko04966 Collecting duct acid secretion ko05323 Rheumatoid arthritis Vacuolar H+-ATPase V1 sector, subunit B C Energy production and conversion ; IPR000194 [ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain] ; IPR004100[ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain] -- -- Q3UK83 Heterogeneous nuclear ribonucleoprotein A1 Hnrnpa1 8174.7 8755.3 8097.8 7309.5 7486 7056 1.14535844221221 0.0119493410566308 0.195799163279638 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) heterogeneous nuclear ribonucleoprotein A1/A3 -- ko03040 Spliceosome FOG: RRM domain R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- Q9Z1W8 Potassium-transporting ATPase alpha chain 2 Atp12a 1915.9 1611.8 1635.6 3895.3 3964.5 3815.8 0.442229949638562 0.0000344341405614223 -1.17713136115819 Significant down 2 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:metal ion binding (GO:0046872) non-gastric H+/K+-exchanging ATPase 3.6.3.10 ko00190 Oxidative phosphorylation Na+/K+ ATPase, alpha subunit P Inorganic ion transport and metabolism ; IPR004014 [Cation-transporting P-type ATPase, N-terminal] ; IPR006068[Cation-transporting P-type ATPase, C-terminal] ; IPR008250[P-type ATPase, A domain] -- -- P62192 26S proteasome regulatory subunit 4 Psmc1 4827.3 4626.5 4783.5 4528.3 4663.4 4539.9 1.03682746366046 0.0871010983549369 0.0521758381904951 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) 26S proteasome regulatory subunit T2 -- ko03050 Proteasome ko05165 Human papillomavirus infection ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis 26S proteasome regulatory complex, ATPase RPT2 O Posttranslational modification, protein turnover, chaperones ; IPR003959 [ATPase, AAA-type, core] -- -- P48036 Annexin A5 Anxa5 12451.7 12781.9 12228.7 12307.9 12189.1 12056 1.02487620715126 0.160869431703342 0.0354496598627839 Nonsignificant None 2 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:calcium-dependent phospholipid binding (GO:0005544) annexin A5 -- -- Annexin U Intracellular trafficking, secretion, and vesicular transport ; IPR018502 [Annexin repeat] -- -- Q3TS44 Proteasome subunit alpha type Psma1 9647.9 9520.8 9370.8 9380 9552.9 9488.1 1.00416945216565 0.697832762318433 0.00600274256667032 Nonsignificant None 5 Molecular Function:endopeptidase activity (GO:0004175),Molecular Function:threonine-type endopeptidase activity (GO:0004298),Cellular Component:proteasome core complex (GO:0005839),Biological Process:ubiquitin-dependent protein catabolic process (GO:0006511),Biological Process:proteolysis involved in cellular protein catabolic process (GO:0051603) 20S proteasome subunit alpha 6 3.4.25.1 ko03050 Proteasome 20S proteasome, regulatory subunit alpha type PSMA1/PRE5 O Posttranslational modification, protein turnover, chaperones ; IPR000426 [Proteasome alpha-subunit, N-terminal domain] ; IPR001353[Proteasome, subunit alpha/beta] -- -- B2RSV4 Splicing factor 3b, subunit 3 Sf3b3 7710 7855 7919.5 7090.7 7339.7 7202 1.08561694495294 0.00289151388347265 0.118515144484722 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Cellular Component:nucleus (GO:0005634) splicing factor 3B subunit 3 -- ko03040 Spliceosome Splicing factor 3b, subunit 3 A RNA processing and modification ; IPR004871 [Cleavage/polyadenylation specificity factor, A subunit, C-terminal] -- -- Q3U7R1 Extended synaptotagmin-1 Esyt1 7313.8 8115.3 8115.1 8287.4 8294.5 7996.1 0.957937993327366 0.292679839255986 -0.0619958205692104 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:lipid binding (GO:0008289) -- -- -- Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain R General function prediction only ; IPR000008 [C2 domain] ; IPR031468[Synaptotagmin-like mitochondrial-lipid-binding domain] -- -- A0A0R4J0I9 Prolow-density lipoprotein receptor-related protein 1 Lrp1 7532.2 7589.1 6899.9 6679.6 6909.5 6855 1.07714206054559 0.08564418784984 0.107208534495817 Nonsignificant None 2 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:protein binding (GO:0005515) low-density lipoprotein receptor-related protein 1 (alpha-2-macroglobulin receptor) -- ko04979 Cholesterol metabolism ko05010 Alzheimer's disease ko05144 Malaria Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains T Signal transduction mechanisms ; IPR000033 [LDLR class B repeat] ; IPR000742[EGF-like domain] ; IPR001881[EGF-like calcium-binding domain] ; IPR002172[Low-density lipoprotein (LDL) receptor class A repeat] ; IPR026823[Complement Clr-like EGF domain] ; IPR032485[Domain of unknown function DUF5050] -- -- Q642K0 Myl6 protein Myl6 16775 19488.3 13588.5 15616.9 14486.7 14285.7 1.12305893537407 0.357991506332459 0.167433638816774 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) myosin light chain 6 -- ko04270 Vascular smooth muscle contraction ko04530 Tight junction ko04921 Oxytocin signaling pathway Myosin essential light chain, EF-Hand protein superfamily Z Cytoskeleton ; IPR002048 [EF-hand domain] -- -- Q8CCV1 Tr-type G domain-containing protein Gspt1 3904.7 3872.3 3849 3218.6 3287.8 3272.7 1.18886196071213 0.0000203409294246705 0.249581212848729 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) peptide chain release factor subunit 3 -- ko03015 mRNA surveillance pathway Polypeptide release factor 3 J Translation, ribosomal structure and biogenesis ; IPR004160 [Translation elongation factor EFTu/EF1A, C-terminal] ; IPR004161[Translation elongation factor EFTu-like, domain 2] -- -- Q3UW98 Chloride channel accessory 4B Clca4b 3587.8 3131.4 2870.1 1889.3 2069.5 1895 1.63813249513137 0.00463882404706518 0.712052049493253 Significant up -- -- calcium-activated chloride channel regulator 3/4 -- ko04924 Renin secretion ko04972 Pancreatic secretion -- -- -- IPR002035 [von Willebrand factor, type A] ; IPR013642[Calcium-activated chloride channel protein] -- -- Q02819 Nucleobindin-1 Nucb1 8330.8 8141.7 8566 8831.3 8966.8 8552.9 0.950191643580889 0.064670149244935 -0.0737095758016482 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) nucleobindin -- -- DNA-binding protein of the nucleobindin family R General function prediction only ; IPR002048 [EF-hand domain] -- -- Q6ZWQ9 Myosin, light chain 12A, regulatory, non-sarcomeric Myl12a 2527.8 2672.9 2714.8 2815.4 2912.8 2668.3 0.942714226165664 0.152482090557868 -0.0851075954367653 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) myosin regulatory light chain 12 -- ko04510 Focal adhesion ko04530 Tight junction ko04611 Platelet activation ko04670 Leukocyte transendothelial migration ko04810 Regulation of actin cytoskeleton Myosin regulatory light chain, EF-Hand protein superfamily Z Cytoskeleton ; IPR002048 [EF-hand domain] -- -- E9Q4K7 Kinesin family member 13B Kif13b 6356.2 5982.6 5542.9 6432.7 6618 6649.8 0.907677470114972 0.0683069036614121 -0.139748346850055 Nonsignificant None 5 Molecular Function:microtubule motor activity (GO:0003777),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Biological Process:microtubule-based movement (GO:0007018),Molecular Function:microtubule binding (GO:0008017) kinesin family member 13 -- -- Kinesin-like protein Z Cytoskeleton ; IPR000253 [Forkhead-associated (FHA) domain] ; IPR000938[CAP Gly-rich domain] ; IPR001752[Kinesin motor domain] ; IPR022140[Kinesin-like KIF1-type] ; IPR022164[Kinesin-like] ; IPR032405[Kinesin-associated] -- -- A8IP69 14-3-3 protein gamma subtype Ywhag 3565 3509.5 3353.1 3617.5 3541.9 3552.1 0.973495775568314 0.234795342371427 -0.0387533764244496 Nonsignificant None -- -- 14-3-3 protein gamma/eta -- ko04110 Cell cycle ko04114 Oocyte meiosis ko04151 PI3K-Akt signaling pathway ko04390 Hippo signaling pathway ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis Multifunctional chaperone (14-3-3 family) O Posttranslational modification, protein turnover, chaperones ; IPR023410 [14-3-3 domain] -- -- Q3TUW9 Uncharacterized protein Ehd1 7193.2 6951.9 7128.2 6632.1 6702.7 7026.2 1.04480624723737 0.0974495696621027 0.0632354283670243 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) EH domain-containing protein 1 -- ko04144 Endocytosis Endocytosis/signaling protein EHD1 TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR000261 [EH domain] ; IPR022812[Dynamin superfamily] ; IPR031692[EH domain-containing protein, N-terminal] -- -- Q6PDI5 Proteasome adapter and scaffold protein ECM29 Ecpas 5427.7 5148.8 5067.3 5209.3 5388.3 5458.4 0.97432735426009 0.356482492427289 -0.0375215248161074 Nonsignificant None 2 Molecular Function:protein complex scaffold (GO:0032947),Biological Process:proteasome assembly (GO:0043248) proteasome component ECM29 -- -- Uncharacterized conserved protein S Function unknown ; IPR024372 [Proteasome component Ecm29] -- -- A0A1S6GWH1 AAA domain-containing protein Psmc5 7229 7013.5 7174.9 6558.7 6833.9 6588.6 1.07187756491102 0.0116097683113142 0.100140123534991 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) 26S proteasome regulatory subunit T6 -- ko03050 Proteasome ko05169 Epstein-Barr virus infection 26S proteasome regulatory complex, ATPase RPT6 O Posttranslational modification, protein turnover, chaperones ; IPR003959 [ATPase, AAA-type, core] -- -- Q545V3 Phosphopyruvate hydratase Eno2 436.1 439.1 572.9 666.4 648.6 667.6 0.730404519318067 0.0560966707540115 -0.453232402980352 Nonsignificant None -- -- enolase 4.2.1.11 ko00010 Glycolysis / Gluconeogenesis ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids ko03018 RNA degradation ko04066 HIF-1 signaling pathway Enolase G Carbohydrate transport and metabolism ; IPR020810 [Enolase, C-terminal TIM barrel domain] ; IPR020811[Enolase, N-terminal] -- -- P62806 Histone H4 H4c1 10583.3 11077.1 9272.7 7947.9 7715.4 8711.6 1.26905546279164 0.0239178589440466 0.343755122091488 Nonsignificant None -- -- histone H4 -- ko05034 Alcoholism ko05203 Viral carcinogenesis ko05322 Systemic lupus erythematosus Histone H4 B Chromatin structure and dynamics ; -- -- -- Q5FWB6 60S acidic ribosomal protein P0 Rplp0 371 339.9 311.6 404.4 325.9 402 0.903029232535547 0.302639871665789 -0.147155404023483 Nonsignificant None 2 Cellular Component:intracellular (GO:0005622),Biological Process:ribosome biogenesis (GO:0042254) large subunit ribosomal protein LP0 -- ko03010 Ribosome 60S acidic ribosomal protein P0 J Translation, ribosomal structure and biogenesis ; IPR001790 [Ribosomal protein L10P] -- -- A0A1L7NR63 C-Cbl associated protein Sorbs1 708.8 777.2 644.6 844.8 798.6 765 0.884653712007972 0.107207690351681 -0.176815256341645 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) sorbin and SH3 domain containing 1 -- ko03320 PPAR signaling pathway ko04520 Adherens junction ko04910 Insulin signaling pathway Sorbin and SH3 domain-containing protein T Signal transduction mechanisms ; IPR001452 [SH3 domain] ; IPR003127[SoHo domain] ; IPR011511[Variant SH3 domain] -- -- A0A2P9DUN6 Serpina1 DOM-7 DOM-7 38.6 36.7 40.7 37.9 37.7 27 1.13060428849903 0.302931424956128 0.17709407440788 Nonsignificant None -- -- alpha-1-antitrypsin -- ko04610 Complement and coagulation cascades Serpin V Defense mechanisms ; IPR023796 [Serpin domain] -- -- Q66JR7 Pgm2 protein (Fragment) Pgm1 8110.5 7779.5 9208.6 8578.5 8456.4 8973.5 0.965018993863521 0.54509986380427 -0.0513707565656746 Nonsignificant None 2 Biological Process:carbohydrate metabolic process (GO:0005975),Biological Process:organic substance metabolic process (GO:0071704) phosphoglucomutase 5.4.2.2 ko00010 Glycolysis / Gluconeogenesis ko00030 Pentose phosphate pathway ko00052 Galactose metabolism ko00230 Purine metabolism ko00500 Starch and sucrose metabolism ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways Phosphoglucomutase G Carbohydrate transport and metabolism ; IPR005843 [Alpha-D-phosphohexomutase, C-terminal] ; IPR005844[Alpha-D-phosphohexomutase, alpha/beta/alpha domain I] ; IPR005845[Alpha-D-phosphohexomutase, alpha/beta/alpha domain II] ; IPR005846[Alpha-D-phosphohexomutase, alpha/beta/alpha domain III] -- -- Q3TYS4 Protein transport protein SEC23 Sec23b 5301 5240.8 5049.4 4818.7 4819 4693.1 1.08795042844782 0.0083519422750778 0.121612822891769 Nonsignificant None 4 Biological Process:intracellular protein transport (GO:0006886),Biological Process:ER to Golgi vesicle-mediated transport (GO:0006888),Molecular Function:zinc ion binding (GO:0008270),Cellular Component:COPII vesicle coat (GO:0030127) protein transport protein SEC23 -- ko04141 Protein processing in endoplasmic reticulum Vesicle coat complex COPII, subunit SEC23 U Intracellular trafficking, secretion, and vesicular transport ; IPR006895 [Zinc finger, Sec23/Sec24-type] ; IPR006896[Sec23/Sec24, trunk domain] ; IPR006900[Sec23/Sec24, helical domain] ; IPR007123[Gelsolin-like domain] ; IPR012990[Sec23/Sec24 beta-sandwich] -- -- P97315 Cysteine and glycine-rich protein 1 Csrp1 10959.4 11706.5 12613.1 15951.3 14536.6 14962.9 0.776201959041425 0.00595179629322727 -0.365496020568714 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) cysteine and glycine-rich protein -- -- Regulatory protein MLP and related LIM proteins TZ Signal transduction mechanisms ; Cytoskeleton ; IPR001781 [Zinc finger, LIM-type] -- -- O35639 Annexin A3 Anxa3 9005.9 8665.5 7768.1 11702.4 11394 11944.2 0.726000696335108 0.00134933862549974 -0.461957162921535 Nonsignificant None 2 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:calcium-dependent phospholipid binding (GO:0005544) annexin A3 -- -- Annexin U Intracellular trafficking, secretion, and vesicular transport ; IPR018502 [Annexin repeat] -- -- Q501J6 Probable ATP-dependent RNA helicase DDX17 Ddx17 4350.2 4370.2 4960.4 4635.1 4803.4 4705.3 0.967264808608719 0.495425049692201 -0.0480171837101408 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase DDX17 3.6.4.13 -- ATP-dependent RNA helicase A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR011545[DEAD/DEAH box helicase domain] -- -- Q5EBP9 Tripartite motif-containing 28 Trim28 7369.5 7148.2 6967.5 6818.2 6882.6 7019.4 1.03692049304543 0.122403686750829 0.0523052782528826 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Cellular Component:intracellular (GO:0005622),Molecular Function:zinc ion binding (GO:0008270) tripartite motif-containing protein 28 2.3.2.27 -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR000315 [B-box-type zinc finger] ; IPR001841[Zinc finger, RING-type] ; IPR019787[Zinc finger, PHD-finger] -- -- Q0VG47 Heterogeneous nuclear ribonucleoprotein A3 Hnrnpa3 1830.5 1704.2 1299.9 1193.9 1163.6 1449.2 1.27002390521974 0.135871289043657 0.34485565260169 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) heterogeneous nuclear ribonucleoprotein A1/A3 -- ko03040 Spliceosome FOG: RRM domain R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- Q99MZ6 Unconventional myosin-VIIb Myo7b 5196.3 4981.7 6187.5 5996.1 6032.9 6045.8 0.905431871998584 0.264606111381439 -0.1433220032729 Nonsignificant None 5 Molecular Function:motor activity (GO:0003774),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Cellular Component:cytoskeleton (GO:0005856),Cellular Component:myosin complex (GO:0016459) myosin VIIb -- -- Myosin VII, myosin IXB and related myosins N Cell motility ; IPR000048 [IQ motif, EF-hand binding site] ; IPR000857[MyTH4 domain] ; IPR001609[Myosin head, motor domain] ; IPR019748[FERM central domain] -- -- Q3UKJ6 RNA helicase Dhx15 8318.3 8460 8386.6 7554.5 7796 7953.2 1.07986714556058 0.00725291371069932 0.110853830693583 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:helicase activity (GO:0004386),Molecular Function:ATP binding (GO:0005524) pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15/PRP43 3.6.4.13 ko03040 Spliceosome mRNA splicing factor ATP-dependent RNA helicase A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR007502[Helicase-associated domain] ; IPR011545[DEAD/DEAH box helicase domain] ; IPR011709[Domain of unknown function DUF1605] -- -- Q4JG03 HECT-type E3 ubiquitin transferase Huwe1 4372.4 4301.5 4018.3 3879 4008.5 4080.9 1.06047591992246 0.121878857777193 0.0847118621670393 Nonsignificant None 1 Molecular Function:ubiquitin-protein transferase activity (GO:0004842) E3 ubiquitin-protein ligase HUWE1 2.3.2.26 ko04120 Ubiquitin mediated proteolysis E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein OK Posttranslational modification, protein turnover, chaperones ; Transcription ; IPR000569 [HECT domain] ; IPR004170[WWE domain] ; IPR010309[E3 ubiquitin ligase, domain of unknown function DUF908] ; IPR010314[E3 ubiquitin ligase, domain of unknown function DUF913] ; IPR015940[Ubiquitin-associated domain] ; IPR025527[Domain of unknown function DUF4414] -- -- O70456 14-3-3 protein sigma Sfn 11699.3 10966.6 6873.2 6429.2 6752 6633.2 1.49078952680879 0.163006236729154 0.576076588900287 Nonsignificant None -- -- stratifin -- ko04110 Cell cycle ko04115 p53 signaling pathway ko04960 Aldosterone-regulated sodium reabsorption Multifunctional chaperone (14-3-3 family) O Posttranslational modification, protein turnover, chaperones ; IPR023410 [14-3-3 domain] -- -- Q6XLQ8 Calumenin Calu 1873.2 1848.4 2326.9 2105.5 2034.3 2062.7 0.975171301894397 0.773666578395604 -0.0362724250652545 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) -- -- -- Reticulocalbin, calumenin, DNA supercoiling factor, and related Ca2+-binding proteins of the CREC family (EF-Hand protein superfamily) TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR002048 [EF-hand domain] -- -- Q9WTP6 Adenylate kinase 2, mitochondrial Ak2 8911.7 8750.8 9602.9 10019 10442 9903.1 0.89794856425845 0.0286026555418501 -0.155295287130887 Nonsignificant None 1 Molecular Function:adenylate kinase activity (GO:0004017) adenylate kinase 2.7.4.3 ko00230 Purine metabolism ko00730 Thiamine metabolism ko01100 Metabolic pathways Adenylate kinase F Nucleotide transport and metabolism ; IPR007862 [Adenylate kinase, active site lid domain] -- -- Q5M8R8 60S acidic ribosomal protein P0 Rplp0 258.1 264.1 225.8 120.7 222.5 120 1.61485319516408 0.0580603053595773 0.691403016785763 Nonsignificant None 2 Cellular Component:intracellular (GO:0005622),Biological Process:ribosome biogenesis (GO:0042254) large subunit ribosomal protein LP0 -- ko03010 Ribosome 60S acidic ribosomal protein P0 J Translation, ribosomal structure and biogenesis ; IPR001790 [Ribosomal protein L10P] -- -- G3UX26 Voltage-dependent anion-selective channel protein 2 Vdac2 11274.4 10883.2 11807.5 12439.6 11890.1 12388 0.925033430743211 0.0456243857603168 -0.112422589262834 Nonsignificant None 2 Cellular Component:mitochondrial outer membrane (GO:0005741),Biological Process:transmembrane transport (GO:0055085) voltage-dependent anion channel protein 2 -- ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04216 Ferroptosis ko04217 Necroptosis ko04218 Cellular senescence ko04621 NOD-like receptor signaling pathway ko04979 Cholesterol metabolism ko05012 Parkinson's disease ko05016 Huntington's disease ko05166 HTLV-I infection Porin/voltage-dependent anion-selective channel protein P Inorganic ion transport and metabolism ; IPR027246 [Eukaryotic porin/Tom40] -- -- Q9QZQ8 Core histone macro-H2A.1 Macroh2a1 5924 5980.7 6514.4 6693.2 6349.6 6886.1 0.924240675601764 0.109089553245621 -0.113659511336572 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) histone H2A -- ko04217 Necroptosis ko05034 Alcoholism ko05322 Systemic lupus erythematosus Histone 2A B Chromatin structure and dynamics ; IPR002589 [Macro domain] ; IPR007125[Histone H2A/H2B/H3] ; IPR032454[Histone H2A, C-terminal domain] -- -- Q921H8 3-ketoacyl-CoA thiolase A, peroxisomal Acaa1a 3818.5 3651.5 4037.5 4151.8 4392.3 4157.9 0.905959691387183 0.0438060533967521 -0.142481232617497 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) acetyl-CoA acyltransferase 1 2.3.1.16 ko00071 Fatty acid degradation ko00280 Valine, leucine and isoleucine degradation ko00592 alpha-Linolenic acid metabolism ko01040 Biosynthesis of unsaturated fatty acids ko01100 Metabolic pathways ko01212 Fatty acid metabolism ko03320 PPAR signaling pathway ko04146 Peroxisome 3-oxoacyl CoA thiolase I Lipid transport and metabolism ; IPR020616 [Thiolase, N-terminal] ; IPR020617[Thiolase, C-terminal] -- -- B9EHJ3 Tight junction protein ZO-1 Tjp1 404.5 410.2 243.4 268.9 314.1 229.6 1.30211666256461 0.243504791195163 0.38085871191632 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) tight junction protein 1 -- ko04520 Adherens junction ko04530 Tight junction ko04540 Gap junction ko05132 Salmonella infection Tight junction proteins T Signal transduction mechanisms ; IPR000906 [ZU5 domain] ; IPR001478[PDZ domain] ; IPR008145[Guanylate kinase/L-type calcium channel beta subunit] ; IPR011511[Variant SH3 domain] -- -- P00920 Carbonic anhydrase 2 Ca2 8528.5 8008.9 9842.2 16477.4 13654.7 16825 0.561780859550526 0.00387405988435876 -0.831920623683904 Significant down -- -- carbonic anhydrase 2 4.2.1.1 ko00910 Nitrogen metabolism ko04964 Proximal tubule bicarbonate reclamation ko04966 Collecting duct acid secretion ko04971 Gastric acid secretion ko04972 Pancreatic secretion ko04976 Bile secretion Carbonic anhydrase R General function prediction only ; IPR001148 [Alpha carbonic anhydrase] -- -- Q99K41 EMILIN-1 Emilin1 4538.5 4642.5 5048.6 5415.7 5321.2 4952 0.906985193353262 0.0817743517997242 -0.140849096118332 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR001073 [C1q domain] ; IPR008160[Collagen triple helix repeat] ; IPR011489[EMI domain] -- -- Q80UG5 Septin-9 Septin9 5514 5446.1 6026.2 5318.2 5627.7 5430.8 1.03722361647951 0.376053305101022 0.0527269603107732 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) septin 3/9/12 -- ko05100 Bacterial invasion of epithelial cells Septin CDC10 and related P-loop GTPases DTZ Cell cycle control, cell division, chromosome partitioning ; Signal transduction mechanisms ; Cytoskeleton ; IPR030379 [Septin-type guanine nucleotide-binding (G) domain] -- -- P47962 60S ribosomal protein L5 Rpl5 16370.3 15900.6 12576.9 11714.4 11760.2 11603.5 1.27851280428529 0.1120075460589 0.354466609219683 Nonsignificant None 5 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412),Molecular Function:5S rRNA binding (GO:0008097) large subunit ribosomal protein L5e -- ko03010 Ribosome 60S ribosomal protein L5 J Translation, ribosomal structure and biogenesis ; IPR005485 [Ribosomal protein L5 eukaryotic/L18 archaeal] ; IPR025607[Ribosomal protein L5 eukaryotic/L18 archaeal, C-terminal] -- -- Q9JJ28 Protein flightless-1 homolog Flii 4123.3 4101.1 4163.1 4128.3 4148.5 4058.6 1.00422361658317 0.623666766978082 0.00608055874496393 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Cytoskeletal regulator Flightless-I (contains leucine-rich and gelsolin repeats) Z Cytoskeleton ; IPR001611 [Leucine-rich repeat] ; IPR007123[Gelsolin-like domain] ; IPR025875[Leucine rich repeat 4] -- -- Q9ERE2 Keratin, type II cuticular Hb1 Krt81 4274 3148 2756.9 1332.9 1156.6 1472.2 2.56932629931595 0.0110917386096291 1.36139012126696 Significant up 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) type II keratin, basic -- -- -- -- -- IPR001664 [Intermediate filament protein] ; IPR032444[Keratin type II head] -- -- Q64511 DNA topoisomerase 2-beta Top2b 3587.4 3565.6 4029.5 3774.6 3854.9 3770.1 0.980955472121829 0.662131346867057 -0.0277404442807715 Nonsignificant None 5 Molecular Function:DNA binding (GO:0003677),Molecular Function:DNA topoisomerase type II (ATP-hydrolyzing) activity (GO:0003918),Molecular Function:ATP binding (GO:0005524),Cellular Component:nucleus (GO:0005634),Biological Process:DNA topological change (GO:0006265) DNA topoisomerase II 5.99.1.3 ko01524 Platinum drug resistance DNA topoisomerase type II B Chromatin structure and dynamics ; IPR002205 [DNA topoisomerase, type IIA, subunit A/C-terminal] ; IPR003594[Histidine kinase-like ATPase, C-terminal domain] ; IPR006171[TOPRIM domain] ; IPR012542[DTHCT] ; IPR013506[DNA topoisomerase, type IIA, subunit B, domain 2] ; IPR031660[C-terminal associated domain of TOPRIM] -- -- E9QAX2 Unconventional myosin-XVIIIa Myo18a 5668 5682.4 6039.4 5679.4 5829.6 5795.9 1.00490612485481 0.837973211557965 0.00706073570061956 Nonsignificant None 4 Molecular Function:motor activity (GO:0003774),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Cellular Component:myosin complex (GO:0016459) myosin XVIII -- -- Myosin class II heavy chain Z Cytoskeleton ; IPR001478 [PDZ domain] ; IPR001609[Myosin head, motor domain] ; IPR002928[Myosin tail] -- -- Q8VHM5 Heterogeneous nuclear ribonucleoprotein R Hnrnpr 4064.8 3917.3 4167.2 3928.3 3935.6 3991.5 1.02479039087673 0.262744829570931 0.0353288531775588 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) heterogeneous nuclear ribonucleoprotein R -- -- Heterogeneous nuclear ribonucleoprotein R (RRM superfamily) A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- P39447 Tight junction protein ZO-1 Tjp1 241 215.5 164 163.2 170.9 138.3 1.31350550381033 0.116198181388884 0.393422245620562 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) tight junction protein 1 -- ko04520 Adherens junction ko04530 Tight junction ko04540 Gap junction ko05132 Salmonella infection Tight junction proteins T Signal transduction mechanisms ; IPR000906 [ZU5 domain] ; IPR001478[PDZ domain] ; IPR008145[Guanylate kinase/L-type calcium channel beta subunit] ; IPR011511[Variant SH3 domain] -- -- P14206 40S ribosomal protein SA Rpsa 6110.8 6213.5 6343.8 5882.5 6010.8 5623.2 1.06574372734279 0.0441918308439712 0.091860564043975 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein SAe -- ko03010 Ribosome 40S ribosomal protein SA (P40)/Laminin receptor 1 J Translation, ribosomal structure and biogenesis ; IPR001865 [Ribosomal protein S2] ; IPR032281[40S ribosomal protein SA, C-terminal domain] -- -- A2AX52 Collagen alpha-4(VI) chain Col6a4 4748.9 4969.7 6944.4 5966.6 6027.4 6342.9 0.90871412288882 0.474506003422027 -0.138101594041799 Nonsignificant None -- -- collagen, type VI, alpha -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04974 Protein digestion and absorption ko05165 Human papillomavirus infection Collagens (type IV and type XIII), and related proteins W Extracellular structures ; IPR002035 [von Willebrand factor, type A] ; IPR008160[Collagen triple helix repeat] -- -- Q9ERU9 E3 SUMO-protein ligase RanBP2 Ranbp2 5828.8 5874 5689.1 5347.3 5531.1 5408.2 1.06786560730908 0.00897801314908294 0.0947300928412337 Nonsignificant None 5 Biological Process:protein peptidyl-prolyl isomerization (GO:0000413),Molecular Function:peptidyl-prolyl cis-trans isomerase activity (GO:0003755),Biological Process:protein folding (GO:0006457),Molecular Function:zinc ion binding (GO:0008270),Biological Process:intracellular transport (GO:0046907) E3 SUMO-protein ligase RanBP2 -- ko03013 RNA transport Ran-binding protein RANBP1 and related RanBD domain proteins U Intracellular trafficking, secretion, and vesicular transport ; IPR000156 [Ran binding domain] ; IPR001876[Zinc finger, RanBP2-type] ; IPR002130[Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain] ; IPR022011[Nup358/RanBP2 E3 ligase domain] -- -- Q9JMH6 Thioredoxin reductase 1, cytoplasmic Txnrd1 6960.6 7278 6593 6669.4 6792.3 7025.4 1.01681545948426 0.634863560185194 0.0240578701051251 Nonsignificant None 3 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:cell redox homeostasis (GO:0045454),Biological Process:oxidation-reduction process (GO:0055114) thioredoxin reductase (NADPH) 1.8.1.9 ko00450 Selenocompound metabolism ko05200 Pathways in cancer ko05225 Hepatocellular carcinoma Thioredoxin reductase O Posttranslational modification, protein turnover, chaperones ; IPR004099 [Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain] ; IPR023753[FAD/NAD(P)-binding domain] -- -- P16460 Argininosuccinate synthase Ass1 5798.1 5287.7 6072.9 6762.6 6666.6 6826 0.847125676369525 0.0117048934974169 -0.239352076658138 Nonsignificant None 3 Molecular Function:argininosuccinate synthase activity (GO:0004055),Molecular Function:ATP binding (GO:0005524),Biological Process:arginine biosynthetic process (GO:0006526) argininosuccinate synthase 6.3.4.5 ko00220 Arginine biosynthesis ko00250 Alanine, aspartate and glutamate metabolism ko01100 Metabolic pathways ko01230 Biosynthesis of amino acids ko05418 Fluid shear stress and atherosclerosis Argininosuccinate synthase E Amino acid transport and metabolism ; IPR001518 [Argininosuccinate synthase] -- -- Q9CZ13 Cytochrome b-c1 complex subunit 1, mitochondrial Uqcrc1 6778.1 6966.5 8147.3 9474.4 9120.8 9029.3 0.792481311878948 0.0131411216714542 -0.335551180553248 Nonsignificant None -- -- ubiquinol-cytochrome c reductase core subunit 1 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04260 Cardiac muscle contraction ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Mitochondrial processing peptidase, beta subunit, and related enzymes (insulinase superfamily) O Posttranslational modification, protein turnover, chaperones ; IPR007863 [Peptidase M16, C-terminal] ; IPR011765[Peptidase M16, N-terminal] -- -- P70124 Serpin B5 Serpinb5 6427.6 6038.9 4947.8 7238 6709.3 6676.1 0.844395201567152 0.0892351140161749 -0.244009714562009 Nonsignificant None -- -- serpin B5 -- ko04115 p53 signaling pathway ko05206 MicroRNAs in cancer Serpin V Defense mechanisms ; IPR023796 [Serpin domain] -- -- P51855 Glutathione synthetase Gss 5926.2 5642.6 6343.8 6952.7 6956 7034.4 0.855298403770216 0.0363710813958089 -0.225500247366598 Nonsignificant None 3 Molecular Function:glutathione synthase activity (GO:0004363),Molecular Function:ATP binding (GO:0005524),Biological Process:glutathione biosynthetic process (GO:0006750) glutathione synthase 6.3.2.3 ko00270 Cysteine and methionine metabolism ko00480 Glutathione metabolism ko01100 Metabolic pathways ko04216 Ferroptosis Glutathione synthetase Q Secondary metabolites biosynthesis, transport and catabolism ; IPR004887 [Glutathione synthase, substrate-binding, eukaryotic] ; IPR005615[Glutathione synthase] -- -- Q8BH59 Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial Slc25a12 3612 3708.9 3857.8 4373.6 4301.8 4338.7 0.858968349713004 0.00119397364770145 -0.219323121327264 Nonsignificant None -- -- solute carrier family 25 (mitochondrial aspartate/glutamate transporter), member 12/13 -- -- Mitochondrial aspartate/glutamate carrier protein Aralar/Citrin (contains EF-hand Ca2+-binding domains) C Energy production and conversion ; IPR018108 [Mitochondrial substrate/solute carrier] -- -- Q91YN5 UDP-N-acetylhexosamine pyrophosphorylase Uap1 4258.2 4171.7 4798.3 4885.9 4764.4 4999.3 0.902973460026212 0.0844175408762163 -0.147244509895797 Nonsignificant None 2 Biological Process:metabolic process (GO:0008152),Molecular Function:uridylyltransferase activity (GO:0070569) -- -- ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways UDP-N-acetylglucosamine pyrophosphorylase M Cell wall/membrane/envelope biogenesis ; IPR002618 [UDPGP family] -- -- Q91WQ3 Tyrosine--tRNA ligase, cytoplasmic Yars1 9312.2 9415.4 8458 9199 9297.1 9053.9 0.986773139745917 0.716465890072844 -0.0192096492967193 Nonsignificant None 5 Molecular Function:tRNA binding (GO:0000049),Molecular Function:nucleotide binding (GO:0000166),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation for protein translation (GO:0006418) tyrosyl-tRNA synthetase 6.1.1.1 ko00970 Aminoacyl-tRNA biosynthesis Tyrosyl-tRNA synthetase, cytoplasmic J Translation, ribosomal structure and biogenesis ; IPR002305 [Aminoacyl-tRNA synthetase, class Ic] ; IPR002547[tRNA-binding domain] -- -- Q5XJY5 Coatomer subunit delta Arcn1 9102.7 9037.8 8986.6 9560.3 9508.5 9198.6 0.959660244663464 0.0320924370939746 -0.059404366237843 Nonsignificant None -- -- coatomer subunit delta -- -- Medium subunit of clathrin adaptor complex U Intracellular trafficking, secretion, and vesicular transport ; IPR022775 [AP complex, mu/sigma subunit] ; IPR028565[Mu homology domain] -- -- Q61739 Integrin alpha-6 Itga6 6660.5 6689.1 5310.4 5588.9 5636.2 5654.1 1.10550263045642 0.321779666615712 0.14470245793742 Nonsignificant None -- -- integrin alpha 6 -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04514 Cell adhesion molecules (CAMs) ko04640 Hematopoietic cell lineage ko04810 Regulation of actin cytoskeleton ko05145 Toxoplasmosis ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05222 Small cell lung cancer ko05410 Hypertrophic cardiomyopathy (HCM) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05414 Dilated cardiomyopathy (DCM) Vitronectin receptor, alpha subunit W Extracellular structures ; IPR013649 [Integrin alpha-2] -- -- P54869 Hydroxymethylglutaryl-CoA synthase, mitochondrial Hmgcs2 8237.9 9055.8 24256.4 8112.4 6173.3 7273.8 1.92722929567012 0.328796101034568 0.946528229156421 Nonsignificant None 2 Molecular Function:hydroxymethylglutaryl-CoA synthase activity (GO:0004421),Biological Process:isoprenoid biosynthetic process (GO:0008299) hydroxymethylglutaryl-CoA synthase 2.3.3.10 ko00072 Synthesis and degradation of ketone bodies ko00280 Valine, leucine and isoleucine degradation ko00650 Butanoate metabolism ko00900 Terpenoid backbone biosynthesis ko01100 Metabolic pathways Hydroxymethylglutaryl-CoA synthase I Lipid transport and metabolism ; IPR013528 [Hydroxymethylglutaryl-coenzyme A synthase, N-terminal] ; IPR013746[Hydroxymethylglutaryl-coenzyme A synthase C-terminal domain] -- -- D3Z3Q3 Smoothelin Smtn 3307.8 3394.3 3561.1 4740 4277.7 4133.9 0.780376532132972 0.00817220788594281 -0.357757701723172 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- FOG: Calponin homology domain R General function prediction only ; IPR001715 [Calponin homology domain] ; IPR022189[Smoothelin] -- -- Q3TUF3 Calumenin Calu 1083.5 1187.6 984.2 726.6 789 780.6 1.41769009668147 0.0066725425884093 0.503542197708435 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) -- -- -- Reticulocalbin, calumenin, DNA supercoiling factor, and related Ca2+-binding proteins of the CREC family (EF-Hand protein superfamily) TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR002048 [EF-hand domain] -- -- A0A1S6GWH4 tRNA (cytosine(34)-C(5))-methyltransferase Nsun2 5675 5506.6 5412.6 4917.4 5180.8 4974.8 1.10092217873018 0.0102254346659804 0.138712492219204 Nonsignificant None 1 Molecular Function:methyltransferase activity (GO:0008168) tRNA (cytosine34-C5)-methyltransferase 2.1.1.203 -- tRNA cytosine-5-methylases and related enzymes of the NOL1/NOP2/sun superfamily J Translation, ribosomal structure and biogenesis ; IPR001678 [SAM-dependent methyltransferase RsmB/NOP2-type] -- -- G5E846 Peripherin Prph 52.7 61 81.6 70.8 85.2 64 0.887727272727273 0.481602426163063 -0.17181157452523 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) peripherin -- ko05014 Amyotrophic lateral sclerosis (ALS) -- -- -- IPR001664 [Intermediate filament protein] ; IPR006821[Intermediate filament head, DNA-binding domain] -- -- Q9JLI0 Aldo-keto reductase a Akr1c12 2208.1 2301 2190.3 2369.5 2231.8 2682.8 0.919729273348801 0.230113404703018 -0.120718835321436 Nonsignificant None -- -- aldo-keto reductase family 1 member C13 1.1.1.218 -- Aldo/keto reductase family proteins R General function prediction only ; IPR023210 [NADP-dependent oxidoreductase domain] -- -- Q6PEE6 AP-2 complex subunit alpha Ap2a2 5309.1 5259.5 4791.4 4829.1 4742.7 5148.4 1.04346408336843 0.358952942739031 0.0613809429625121 Nonsignificant None 4 Biological Process:intracellular protein transport (GO:0006886),Biological Process:vesicle-mediated transport (GO:0016192),Cellular Component:membrane coat (GO:0030117),Cellular Component:clathrin adaptor complex (GO:0030131) AP-2 complex subunit alpha -- ko04144 Endocytosis ko04721 Synaptic vesicle cycle ko04961 Endocrine and other factor-regulated calcium reabsorption ko05016 Huntington's disease Vesicle coat complex AP-2, alpha subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR002553 [Clathrin/coatomer adaptor, adaptin-like, N-terminal] ; IPR003164[Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain] ; IPR008152[Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain] -- -- Q9ERG0 LIM domain and actin-binding protein 1 Lima1 10576.1 10278.3 8184.6 8508.9 8727.4 8357.6 1.13460629290573 0.265237130822103 0.182191770812562 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) -- -- -- Regulatory protein MLP and related LIM proteins TZ Signal transduction mechanisms ; Cytoskeleton ; IPR001781 [Zinc finger, LIM-type] -- -- P62880 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 Gnb2 1405.6 1357.7 1443.6 1733.8 1632.1 1725.9 0.826210770258062 0.00198575382987364 -0.275418227992023 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 -- ko04014 Ras signaling pathway ko04062 Chemokine signaling pathway ko04151 PI3K-Akt signaling pathway ko04371 Apelin signaling pathway ko04713 Circadian entrainment ko04723 Retrograde endocannabinoid signaling ko04724 Glutamatergic synapse ko04725 Cholinergic synapse ko04726 Serotonergic synapse ko04727 GABAergic synapse ko04728 Dopaminergic synapse ko04926 Relaxin signaling pathway ko05032 Morphine addiction ko05034 Alcoholism ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05200 Pathways in cancer G-protein beta subunit R General function prediction only ; IPR001680 [WD40 repeat] -- -- E9QM38 Solute carrier family 12 member 2 Slc12a2 5318 5012.9 5242.6 5683.3 5642.6 5745.8 0.912240725879672 0.00663737388675837 -0.132513515885406 Nonsignificant None 5 Molecular Function:transporter activity (GO:0005215),Biological Process:transport (GO:0006810),Biological Process:ion transport (GO:0006811),Cellular Component:membrane (GO:0016020),Biological Process:transmembrane transport (GO:0055085) solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -- ko04970 Salivary secretion ko04972 Pancreatic secretion Na+/K+ symporter P Inorganic ion transport and metabolism ; IPR004841 [Amino acid permease/ SLC12A domain] ; IPR013612[Amino acid permease, N-terminal] ; IPR018491[SLC12A transporter, C-terminal] -- -- Q00623 Apolipoprotein A-I Apoa1 11697.8 13000 8876.5 6357.4 6756.6 6560.8 1.70646207331205 0.0613601432706009 0.771008350415295 Nonsignificant None 4 Cellular Component:extracellular region (GO:0005576),Biological Process:lipid transport (GO:0006869),Molecular Function:lipid binding (GO:0008289),Biological Process:lipoprotein metabolic process (GO:0042157) apolipoprotein A-I -- ko03320 PPAR signaling pathway ko04975 Fat digestion and absorption ko04977 Vitamin digestion and absorption ko04979 Cholesterol metabolism ko05143 African trypanosomiasis -- -- -- IPR000074 [Apolipoprotein A/E] -- -- Q3V3R1 Monofunctional C1-tetrahydrofolate synthase, mitochondrial Mthfd1l 7700.8 7459.6 7188.9 6427.4 6898.6 6611 1.12099613783418 0.0162982245310189 0.164781307637472 Nonsignificant None 6 Molecular Function:catalytic activity (GO:0003824),Molecular Function:formate-tetrahydrofolate ligase activity (GO:0004329),Molecular Function:methylenetetrahydrofolate dehydrogenase (NADP+) activity (GO:0004488),Molecular Function:ATP binding (GO:0005524),Biological Process:folic acid-containing compound biosynthetic process (GO:0009396),Biological Process:oxidation-reduction process (GO:0055114) monofunctional C1-tetrahydrofolate synthase, mitochondrial 6.3.4.3 ko00670 One carbon pool by folate ko01100 Metabolic pathways C1-tetrahydrofolate synthase H Coenzyme transport and metabolism ; IPR000559 [Formate-tetrahydrofolate ligase, FTHFS] ; IPR020630[Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain] ; IPR020631[Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain] -- -- Q9WUM5 Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial Suclg1 6738.9 7032.4 7613.2 10336.3 9595.6 9360.3 0.730040761704481 0.00251069329091285 -0.453951076008199 Nonsignificant None 3 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152),Molecular Function:cofactor binding (GO:0048037) -- -- ko00020 Citrate cycle (TCA cycle) ko00640 Propanoate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism Succinyl-CoA synthetase, alpha subunit C Energy production and conversion ; IPR003781 [CoA-binding] ; IPR005811[ATP-citrate lyase/succinyl-CoA ligase] -- -- O54891 Galectin-6 Lgals6 1442.9 1414.5 1474.1 1530.1 1489.3 1486.6 0.96127385707945 0.0590217088044431 -0.0569805962856096 Nonsignificant None 1 Molecular Function:carbohydrate binding (GO:0030246) galectin-4 -- -- Galectin, galactose-binding lectin W Extracellular structures ; IPR001079 [Galectin, carbohydrate recognition domain] -- -- H7BX64 Sarcolemmal membrane-associated protein Slmap 6293.3 6769.6 7469.2 8451.3 8149.1 7643.9 0.846883597381653 0.0406214167757848 -0.2397644075268 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR000253 [Forkhead-associated (FHA) domain] -- -- P15331 Peripherin Prph 157.1 159.5 161.8 147.8 161.7 159.1 1.02091335894153 0.506041620969066 0.0298604353349696 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) peripherin -- ko05014 Amyotrophic lateral sclerosis (ALS) -- -- -- IPR001664 [Intermediate filament protein] ; IPR006821[Intermediate filament head, DNA-binding domain] -- -- Q3V471 Galectin (Fragment) Lgals3 13042.8 11938.3 11123.7 13815.2 13850.6 14078.6 0.864901639501346 0.0744430621478801 -0.20939202256842 Nonsignificant None 1 Molecular Function:carbohydrate binding (GO:0030246) galectin-3 -- -- Galectin, galactose-binding lectin W Extracellular structures ; IPR001079 [Galectin, carbohydrate recognition domain] -- -- Q3UW53 Protein Niban 1 Niban1 8098.9 8234.5 8112.4 9172.2 8895.8 9214.7 0.896018355954506 0.000967335396706227 -0.15839980705395 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- O70400 PDZ and LIM domain protein 1 Pdlim1 5641.4 5748.3 5968.8 6900.4 6759.9 6736.7 0.851032014511938 0.000749341510087816 -0.232714689992748 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:zinc ion binding (GO:0008270) -- -- -- Adaptor protein Enigma and related PDZ-LIM proteins TZ Signal transduction mechanisms ; Cytoskeleton ; IPR001478 [PDZ domain] ; IPR001781[Zinc finger, LIM-type] ; IPR031847[Domain of unknown function DUF4749] -- -- P56399 Ubiquitin carboxyl-terminal hydrolase 5 Usp5 5323.4 5055.3 5037.3 5227.2 5215.6 5242.3 0.982843590413832 0.434664586012998 -0.0249662503341408 Nonsignificant None 3 Molecular Function:zinc ion binding (GO:0008270),Biological Process:protein deubiquitination (GO:0016579),Molecular Function:thiol-dependent ubiquitinyl hydrolase activity (GO:0036459) ubiquitin carboxyl-terminal hydrolase 5/13 3.4.19.12 -- Ubiquitin-specific protease UBP14 O Posttranslational modification, protein turnover, chaperones ; IPR001394 [Peptidase C19, ubiquitin carboxyl-terminal hydrolase] ; IPR001607[Zinc finger, UBP-type] ; IPR015940[Ubiquitin-associated domain] -- -- Q8VCW8 Medium-chain acyl-CoA ligase ACSF2, mitochondrial Acsf2 4591.2 4424 6685 6895.9 6201.1 6846.8 0.787222094084377 0.136620859334359 -0.345157383129596 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) fatty-acyl-CoA synthase 6.2.1.- -- Long chain fatty acid acyl-CoA ligase I Lipid transport and metabolism ; IPR000873 [AMP-dependent synthetase/ligase] ; IPR025110[AMP-binding enzyme C-terminal domain] -- -- Q91VR5 ATP-dependent RNA helicase DDX1 Ddx1 8346.7 8283.2 9182 9185.8 9211.2 9007.7 0.941878582870821 0.147928562138179 -0.0863870002086088 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase DDX1 3.6.4.13 -- Putative DEAD-box RNA helicase DDX1 A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR003877[SPRY domain] ; IPR011545[DEAD/DEAH box helicase domain] -- -- Q60967 Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 1 Papss1 2895.8 2716.5 3442.1 4587.9 4097.9 4411.4 0.691323336285618 0.00668747306265346 -0.532567468858508 Nonsignificant None 1 Molecular Function:sulfate adenylyltransferase (ATP) activity (GO:0004781) -- -- ko00230 Purine metabolism ko00450 Selenocompound metabolism ko00920 Sulfur metabolism ko01100 Metabolic pathways Bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase F Nucleotide transport and metabolism ; IPR024951 [Sulphate adenylyltransferase catalytic domain] ; IPR025980[ATP-sulfurylase PUA-like domain] -- -- A0A087WS29 Kinectin Ktn1 94.2 72.3 69.5 76.7 85.6 83.8 0.958959772450224 0.704706664322259 -0.0604577982089561 Nonsignificant None 2 Biological Process:protein transport (GO:0015031),Cellular Component:integral component of endoplasmic reticulum membrane (GO:0030176) kinectin -- -- -- -- -- IPR007794 [Ribosome receptor lysine/proline rich] -- -- Q61425 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial Hadh 6840.2 6452.3 9492.7 11176.3 10120.5 11400.6 0.696850514108155 0.0330163011224004 -0.521078887408836 Nonsignificant None 4 Molecular Function:3-hydroxyacyl-CoA dehydrogenase activity (GO:0003857),Biological Process:fatty acid metabolic process (GO:0006631),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) 3-hydroxyacyl-CoA dehydrogenase 1.1.1.35 ko00062 Fatty acid elongation ko00071 Fatty acid degradation ko00280 Valine, leucine and isoleucine degradation ko00310 Lysine degradation ko00380 Tryptophan metabolism ko00650 Butanoate metabolism ko01100 Metabolic pathways ko01212 Fatty acid metabolism 3-hydroxyacyl-CoA dehydrogenase I Lipid transport and metabolism ; IPR006108 [3-hydroxyacyl-CoA dehydrogenase, C-terminal] ; IPR006176[3-hydroxyacyl-CoA dehydrogenase, NAD binding] -- -- Q9CU62 Structural maintenance of chromosomes protein 1A Smc1a 6207.2 6141.5 6088.3 5960.3 6031.6 6275.6 1.00927877377857 0.607324010582347 0.0133247175550173 Nonsignificant None 4 Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Cellular Component:chromosome (GO:0005694),Biological Process:chromosome organization (GO:0051276) structural maintenance of chromosome 1 -- ko04110 Cell cycle ko04114 Oocyte meiosis Structural maintenance of chromosome protein 1 (sister chromatid cohesion complex Cohesin, subunit SMC1) D Cell cycle control, cell division, chromosome partitioning ; IPR003395 [RecF/RecN/SMC, N-terminal] ; IPR010935[SMCs flexible hinge] -- -- Q9Z1N5 Spliceosome RNA helicase Ddx39b Ddx39b 3593.8 3483.7 3766.1 3712.7 3692.4 3825.7 0.96552338212772 0.233499156404373 -0.0506168974708941 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase UAP56/SUB2 3.6.4.13 ko03013 RNA transport ko03015 mRNA surveillance pathway ko03040 Spliceosome ko05164 Influenza A ATP-dependent RNA helicase A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR011545[DEAD/DEAH box helicase domain] -- -- Q9Z0S1 3(2),5-bisphosphate nucleotidase 1 Bpnt1 5643.3 5104 5996.2 6730.9 6571.3 7008.6 0.824364377572523 0.0147080115143538 -0.278645930390871 Nonsignificant None 1 Biological Process:phosphatidylinositol phosphorylation (GO:0046854) 3'(2'), 5'-bisphosphate nucleotidase 3.1.3.7 ko00920 Sulfur metabolism ko01100 Metabolic pathways Bisphosphate 3'-nucleotidase BPNT1/Inositol polyphosphate 1-phosphatase F Nucleotide transport and metabolism ; IPR000760 [Inositol monophosphatase-like] -- -- Q6GQT9 Nodal modulator 1 Nomo1 3311.5 3338 3891.3 3734.7 3893.3 3559.9 0.942160727214222 0.366707574496983 -0.0859548985577532 Nonsignificant None -- -- -- -- -- Metalloproteinase-related collagenase pM5 O Posttranslational modification, protein turnover, chaperones ; -- -- -- D3YUM1 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial Ndufv1 6933 6832.1 8056.9 9747.7 9492.5 9873.1 0.749554327403626 0.00399320049857392 -0.415895046953949 Nonsignificant None -- -- -- -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease NADH:ubiquinone oxidoreductase, NDUFV1/51kDa subunit C Energy production and conversion ; IPR011538 [NADH-ubiquinone oxidoreductase 51 kDa subunit, FMN-binding domain] ; IPR019554[Soluble ligand binding domain] ; IPR019575[NADH-ubiquinone oxidoreductase 51 kDa subunit, iron-sulphur binding domain] -- -- Q8C3V4 Signal transducer and activator of transcription Stat1 5405.4 6211.2 5445.1 4389.5 4861.5 4506.8 1.24014740728896 0.020950788955058 0.310511613455192 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Biological Process:signal transduction (GO:0007165) signal transducer and activator of transcription 1 -- ko04062 Chemokine signaling pathway ko04217 Necroptosis ko04380 Osteoclast differentiation ko04620 Toll-like receptor signaling pathway ko04621 NOD-like receptor signaling pathway ko04630 Jak-STAT signaling pathway ko04658 Th1 and Th2 cell differentiation ko04659 Th17 cell differentiation ko04917 Prolactin signaling pathway ko04919 Thyroid hormone signaling pathway ko04933 AGE-RAGE signaling pathway in diabetic complications ko05140 Leishmaniasis ko05145 Toxoplasmosis ko05152 Tuberculosis ko05160 Hepatitis C ko05161 Hepatitis B ko05162 Measles ko05164 Influenza A ko05165 Human papillomavirus infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection ko05200 Pathways in cancer ko05212 Pancreatic cancer ko05321 Inflammatory bowel disease (IBD) STAT protein KT Transcription ; Signal transduction mechanisms ; IPR000980 [SH2 domain] ; IPR013799[STAT transcription factor, protein interaction] ; IPR013800[STAT transcription factor, all-alpha domain] ; IPR013801[STAT transcription factor, DNA-binding] ; IPR022752[Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal] -- STAT A0A087WPX0 Kinectin Ktn1 21.5 20.8 21.7 32.8 34.2 25.2 0.6941431670282 0.076878939886779 -0.526694845541976 Nonsignificant None 2 Biological Process:protein transport (GO:0015031),Cellular Component:integral component of endoplasmic reticulum membrane (GO:0030176) kinectin -- -- -- -- -- IPR007794 [Ribosome receptor lysine/proline rich] -- -- P70227 Inositol 1,4,5-trisphosphate receptor type 3 Itpr3 3965.1 3952.9 4209.2 4216.1 4489.3 4254.7 0.935733520574687 0.0806617054592276 -0.0958303591834734 Nonsignificant None 6 Molecular Function:ion channel activity (GO:0005216),Molecular Function:calcium channel activity (GO:0005262),Biological Process:ion transport (GO:0006811),Cellular Component:membrane (GO:0016020),Biological Process:transmembrane transport (GO:0055085),Biological Process:calcium ion transmembrane transport (GO:0070588) inositol 1,4,5-triphosphate receptor type 3 -- ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04070 Phosphatidylinositol signaling system ko04114 Oocyte meiosis ko04210 Apoptosis ko04218 Cellular senescence ko04270 Vascular smooth muscle contraction ko04371 Apelin signaling pathway ko04540 Gap junction ko04611 Platelet activation ko04621 NOD-like receptor signaling pathway ko04713 Circadian entrainment ko04720 Long-term potentiation ko04723 Retrograde endocannabinoid signaling ko04724 Glutamatergic synapse ko04725 Cholinergic synapse ko04726 Serotonergic synapse ko04728 Dopaminergic synapse ko04730 Long-term depression ko04742 Taste transduction ko04750 Inflammatory mediator regulation of TRP channels ko04911 Insulin secretion ko04912 GnRH signaling pathway ko04915 Estrogen signaling pathway ko04918 Thyroid hormone synthesis ko04921 Oxytocin signaling pathway ko04922 Glucagon signaling pathway ko04924 Renin secretion ko04925 Aldosterone synthesis and secretion ko04970 Salivary secretion ko04971 Gastric acid secretion ko04972 Pancreatic secretion ko05010 Alzheimer's disease ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05205 Proteoglycans in cancer Inositol 1,4,5-trisphosphate receptor T Signal transduction mechanisms ; IPR000699 [RIH (RyR and IP3R Homology) domain] ; IPR005821[Ion transport domain] ; IPR013662[RyR/IP3R Homology associated domain] ; IPR014821[Inositol 1,4,5-trisphosphate/ryanodine receptor] ; IPR016093[MIR motif] -- -- Q3TRJ1 Vacuolar protein sorting-associated protein 35 Vps35 4227.2 4237.9 4518.1 4758.9 4423.6 4927.4 0.920148264693584 0.0998366580604017 -0.120061751647936 Nonsignificant None 3 Molecular Function:protein transporter activity (GO:0008565),Biological Process:protein transport (GO:0015031),Cellular Component:retromer complex (GO:0030904) vacuolar protein sorting-associated protein 35 -- ko04144 Endocytosis Membrane coat complex Retromer, subunit VPS35 U Intracellular trafficking, secretion, and vesicular transport ; IPR005378 [Vacuolar protein sorting-associated protein 35] -- -- P68510 14-3-3 protein eta Ywhah 7732 7580.4 8262.9 7994.3 8038.5 8245.8 0.971032102345275 0.348514278491723 -0.0424091029208023 Nonsignificant None -- -- 14-3-3 protein gamma/eta -- ko04110 Cell cycle ko04114 Oocyte meiosis ko04151 PI3K-Akt signaling pathway ko04390 Hippo signaling pathway ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis Multifunctional chaperone (14-3-3 family) O Posttranslational modification, protein turnover, chaperones ; IPR023410 [14-3-3 domain] -- -- Q99LC5 Electron transfer flavoprotein subunit alpha, mitochondrial Etfa 8221.9 7964.3 9326.2 9981.8 9134.3 10444.4 0.863057120143435 0.0760440612821809 -0.212472049711849 Nonsignificant None -- -- electron transfer flavoprotein alpha subunit -- -- Electron transfer flavoprotein, alpha subunit C Energy production and conversion ; IPR014730 [Electron transfer flavoprotein, alpha/beta-subunit, N-terminal] ; IPR014731[Electron transfer flavoprotein, alpha subunit, C-terminal] -- -- O70569 Ribosomal protein S14 rps14 8486.1 8751.3 6837 5967.8 6080.4 5884.6 1.34247858672377 0.0746661861010637 0.424899076610088 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S14e -- ko03010 Ribosome 40S ribosomal protein S14 J Translation, ribosomal structure and biogenesis ; IPR001971 [Ribosomal protein S11] -- -- E9PXY8 Ubiquitin carboxyl-terminal hydrolase 7 Usp7 4019.3 3995.6 4071 3956.2 4124.2 4040.9 0.997079521173471 0.835822395293553 -0.00421952484001454 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Biological Process:protein deubiquitination (GO:0016579),Molecular Function:thiol-dependent ubiquitinyl hydrolase activity (GO:0036459) ubiquitin carboxyl-terminal hydrolase 7 3.4.19.12 ko04068 FoxO signaling pathway ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis Ubiquitin carboxyl-terminal hydrolase O Posttranslational modification, protein turnover, chaperones ; IPR001394 [Peptidase C19, ubiquitin carboxyl-terminal hydrolase] ; IPR002083[MATH/TRAF domain] ; IPR024729[Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain] ; IPR029346[Ubiquitin carboxyl-terminal hydrolase, C-terminal] -- -- Q9Z2I9 Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial Sucla2 6342.4 6183 7655.5 8513.1 8023.8 8341.2 0.811191369115809 0.0326481719610818 -0.301885792398258 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) -- -- ko00020 Citrate cycle (TCA cycle) ko00640 Propanoate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism Succinyl-CoA synthetase, beta subunit C Energy production and conversion ; IPR005811 [ATP-citrate lyase/succinyl-CoA ligase] ; IPR013650[ATP-grasp fold, succinyl-CoA synthetase-type] -- -- P28653 Biglycan Bgn 4450.9 4523.3 4667.2 5852.8 6158.9 5613.2 0.773984533245579 0.0014574866640594 -0.369623358017486 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) biglycan -- -- FOG: Leucine rich repeat R General function prediction only ; IPR000372 [Leucine-rich repeat N-terminal domain] ; IPR001611[Leucine-rich repeat] -- -- Q9Z1Z0 General vesicular transport factor p115 Uso1 4990.5 5043.7 5545.1 5672.7 5770.3 5487.7 0.920180500510906 0.0821731204693182 -0.120011210185265 Nonsignificant None 6 Cellular Component:Golgi membrane (GO:0000139),Cellular Component:cytoplasm (GO:0005737),Biological Process:intracellular protein transport (GO:0006886),Molecular Function:protein transporter activity (GO:0008565),Cellular Component:membrane (GO:0016020),Biological Process:vesicle fusion with Golgi apparatus (GO:0048280) -- -- -- ER-Golgi vesicle-tethering protein p115 U Intracellular trafficking, secretion, and vesicular transport ; IPR006953 [Vesicle tethering protein Uso1/P115-like , head domain] ; IPR006955[Uso1/p115-like vesicle tethering protein, C-terminal] -- -- P13634 Carbonic anhydrase 1 Ca1 4878.1 4344.5 11886.9 10598.1 7239.4 8624.1 0.797740877346797 0.533029316602973 -0.326007889385644 Nonsignificant None -- -- carbonic anhydrase 4.2.1.1 ko00910 Nitrogen metabolism Carbonic anhydrase R General function prediction only ; IPR001148 [Alpha carbonic anhydrase] -- -- Q4VA29 RNA transcription, translation and transport factor protein Rtraf 4045.7 4234.8 5016.2 4931.7 4843.3 4653.9 0.921532479953427 0.287852699604947 -0.117893079501317 Nonsignificant None -- -- RLL motif containing protein 1 -- -- Carnitine deficiency associated protein R General function prediction only ; IPR019265 [Protein of unknown function UPF0568] -- -- Q3UPJ8 HATPase_c domain-containing protein Trap1 7654.2 7114.8 7200.5 7189 7050.8 7077 1.03061904225775 0.276088847450921 0.043511153839778 Nonsignificant None 4 Molecular Function:ATP binding (GO:0005524),Biological Process:protein folding (GO:0006457),Biological Process:response to stress (GO:0006950),Molecular Function:unfolded protein binding (GO:0051082) TNF receptor-associated protein 1 -- -- Molecular chaperone (HSP90 family) O Posttranslational modification, protein turnover, chaperones ; IPR001404 [Heat shock protein Hsp90 family] -- -- Q6IWE3 Glyceraldehyde-3-phosphate-dehydrogenase (Fragment) Gapd 18.3 29.1 26.7 24.8 26.5 24.1 0.982758620689655 0.903344346596323 -0.0250909809628305 Nonsignificant None 1 Biological Process:oxidation-reduction process (GO:0055114) glyceraldehyde 3-phosphate dehydrogenase 1.2.1.12 ko00010 Glycolysis / Gluconeogenesis ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids ko04066 HIF-1 signaling pathway ko05010 Alzheimer's disease Glyceraldehyde 3-phosphate dehydrogenase G Carbohydrate transport and metabolism ; IPR020829 [Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain] -- -- Q8CGK3 Lon protease homolog, mitochondrial Lonp1 7527 7348 7582.9 7594 7453.6 7683 0.988002956367188 0.403315008523414 -0.0174127361443125 Nonsignificant None 4 Molecular Function:ATP-dependent peptidase activity (GO:0004176),Molecular Function:serine-type endopeptidase activity (GO:0004252),Molecular Function:ATP binding (GO:0005524),Biological Process:proteolysis (GO:0006508) ATP-dependent Lon protease 3.4.21.53 -- Mitochondrial ATP-dependent protease PIM1/LON O Posttranslational modification, protein turnover, chaperones ; IPR003111 [ATP-dependent protease La (LON), substrate-binding domain] ; IPR003959[ATPase, AAA-type, core] ; IPR008269[Peptidase S16, Lon C-terminal] -- -- Q91WD5 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial Ndufs2 6875.4 7153.6 7253 7443.6 7249.5 7577 0.95563109281054 0.0895880509533031 -0.0654743002038174 Nonsignificant None 3 Molecular Function:quinone binding (GO:0048038),Molecular Function:NAD binding (GO:0051287),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease NADH:ubiquinone oxidoreductase, NDUFS2/49 kDa subunit C Energy production and conversion ; IPR001135 [NADH-quinone oxidoreductase, subunit D] -- -- Q921K2 Poly [ADP-ribose] polymerase Parp1 5745.1 5457.9 6026.2 6002 6049.1 6227.1 0.942609228479828 0.120636214313264 -0.0852682889670384 Nonsignificant None 4 Molecular Function:DNA binding (GO:0003677),Molecular Function:NAD+ ADP-ribosyltransferase activity (GO:0003950),Biological Process:protein ADP-ribosylation (GO:0006471),Molecular Function:zinc ion binding (GO:0008270) poly [ADP-ribose] polymerase 2.4.2.30 ko03410 Base excision repair ko04210 Apoptosis ko04217 Necroptosis NAD+ ADP-ribosyltransferase Parp, required for poly-ADP ribosylation of nuclear proteins KLO Transcription ; Replication, recombination and repair ; Posttranslational modification, protein turnover, chaperones ; IPR001357 [BRCT domain] ; IPR001510[Zinc finger, PARP-type] ; IPR004102[Poly(ADP-ribose) polymerase, regulatory domain] ; IPR008893[WGR domain] ; IPR012317[Poly(ADP-ribose) polymerase, catalytic domain] ; IPR012982[PADR1 domain] -- -- P46935 E3 ubiquitin-protein ligase NEDD4 Nedd4 6782.6 6660.9 7024.6 6122.9 6162.1 6246.3 1.10451506370303 0.00463002545475154 0.143413094728919 Nonsignificant None 2 Molecular Function:ubiquitin-protein transferase activity (GO:0004842),Molecular Function:protein binding (GO:0005515) E3 ubiquitin-protein ligase NEDD4 2.3.2.26 ko04120 Ubiquitin mediated proteolysis ko04144 Endocytosis ko04530 Tight junction ko05169 Epstein-Barr virus infection Ubiquitin protein ligase RSP5/NEDD4 O Posttranslational modification, protein turnover, chaperones ; IPR000008 [C2 domain] ; IPR000569[HECT domain] ; IPR001202[WW domain] -- -- Q9DBP5 UMP-CMP kinase Cmpk1 6792.7 6195.6 7126 8215.8 7816.8 8213.4 0.82959251010476 0.0104240759639507 -0.269525225909197 Nonsignificant None -- -- -- -- ko00240 Pyrimidine metabolism ko01100 Metabolic pathways Uridylate kinase/adenylate kinase F Nucleotide transport and metabolism ; -- -- -- Q80YP5 Integrin alpha 5 (Fibronectin receptor alpha) Itga5 7874 8104.7 7450.5 7578.3 7466.5 7087.6 1.05859283222787 0.149078937833225 0.0821477905757693 Nonsignificant None -- -- integrin alpha 5 -- ko04145 Phagosome ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04640 Hematopoietic cell lineage ko04810 Regulation of actin cytoskeleton ko05100 Bacterial invasion of epithelial cells ko05133 Pertussis ko05165 Human papillomavirus infection ko05205 Proteoglycans in cancer ko05206 MicroRNAs in cancer ko05410 Hypertrophic cardiomyopathy (HCM) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05414 Dilated cardiomyopathy (DCM) Vitronectin receptor, alpha subunit W Extracellular structures ; IPR013517 [FG-GAP repeat] ; IPR013649[Integrin alpha-2] -- -- Q8BU30 Isoleucine--tRNA ligase, cytoplasmic Iars1 8594.3 8764.5 7609 7089.1 7253.4 7121.5 1.16324077525158 0.0806586105259959 0.218149746259946 Nonsignificant None 4 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation for protein translation (GO:0006418) isoleucyl-tRNA synthetase 6.1.1.5 ko00970 Aminoacyl-tRNA biosynthesis Isoleucyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR002300 [Aminoacyl-tRNA synthetase, class Ia] ; IPR013155[Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding] -- -- P14148 60S ribosomal protein L7 Rpl7 9921.1 10316.9 11150.6 10072 9912.4 9666.1 1.05861958482994 0.203084107060241 0.0821842496915659 Nonsignificant None -- -- large subunit ribosomal protein L7e -- ko03010 Ribosome 60S ribosomal protein L7 J Translation, ribosomal structure and biogenesis ; IPR012988 [Ribosomal protein L30, N-terminal] ; IPR016082[Ribosomal protein L30, ferredoxin-like fold domain] -- -- Q3U5I2 Polypyrimidine tract-binding protein 1 Ptbp1 2.3 1.8 0 0 3.1 2.1 0.788461538461538 0.428908455183718 -0.342887713523009 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) polypyrimidine tract-binding protein 1 -- -- Polypyrimidine tract-binding protein A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- P50516 V-type proton ATPase catalytic subunit A Atp6v1a 4309.8 4352.7 4458.2 4331.1 4486.5 4501.1 0.98513368421843 0.399274538172566 -0.0216085810063696 Nonsignificant None 3 Molecular Function:ATP binding (GO:0005524),Biological Process:proton transport (GO:0015992),Biological Process:ATP metabolic process (GO:0046034) V-type H+-transporting ATPase subunit A 3.6.3.14 ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04145 Phagosome ko04150 mTOR signaling pathway ko04721 Synaptic vesicle cycle ko04966 Collecting duct acid secretion ko05323 Rheumatoid arthritis Vacuolar H+-ATPase V1 sector, subunit A C Energy production and conversion ; IPR000194 [ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain] ; IPR004100[ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain] ; IPR031686[ATPsynthase alpha/beta subunit, N-terminal extension] -- -- Q5SW83 Uncharacterized protein Actr2 9798.8 9591.2 9401 9205.7 9264 9496.1 1.02950746983816 0.130941821450781 0.041954297827741 Nonsignificant None -- -- actin-related protein 2 -- ko04530 Tight junction Actin-related protein Arp2/3 complex, subunit Arp2 Z Cytoskeleton ; IPR004000 [Actin family] -- -- O54724 Caveolae-associated protein 1 Cavin1 6808.2 6631.9 6853.2 8344.2 8170.3 8494 0.811456104924326 0.000168043034746163 -0.301415039449644 Nonsignificant None -- -- polymerase I and transcript release factor -- -- -- -- -- IPR026752 [Cavin family] -- -- Q91ZW3 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 Smarca5 7911.6 7843.2 7529.6 6847.5 6795.8 6835.8 1.1369835588478 0.0142083703395494 0.185211392541296 Nonsignificant None 7 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:DNA binding (GO:0003677),Molecular Function:ATP binding (GO:0005524),Cellular Component:nucleus (GO:0005634),Biological Process:chromatin remodeling (GO:0006338),Molecular Function:nucleosome binding (GO:0031491),Biological Process:ATP-dependent chromatin remodeling (GO:0043044) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 3.6.4.- -- Chromatin remodeling complex WSTF-ISWI, small subunit K Transcription ; IPR000330 [SNF2-related, N-terminal domain] ; IPR001650[Helicase, C-terminal] ; IPR015194[ISWI, HAND domain] ; IPR015195[SLIDE domain] ; IPR020838[DBINO domain] -- -- Q9Z110 Delta-1-pyrroline-5-carboxylate synthase Aldh18a1 5175 5082.7 5904.2 4906.4 4906.4 4553.5 1.12498694862282 0.103819474834613 0.169908264316661 Nonsignificant None 3 Biological Process:metabolic process (GO:0008152),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00330 Arginine and proline metabolism ko01100 Metabolic pathways ko01230 Biosynthesis of amino acids Gamma-glutamyl phosphate reductase E Amino acid transport and metabolism ; IPR001048 [Aspartate/glutamate/uridylate kinase] ; IPR015590[Aldehyde dehydrogenase domain] -- -- Q8C140 Uncharacterized protein Slc25a13 3027.9 2813.1 3447.9 3358 3314.3 3571.4 0.906791491355663 0.1913488942538 -0.141157240902379 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) solute carrier family 25 (mitochondrial aspartate/glutamate transporter), member 12/13 -- -- Mitochondrial aspartate/glutamate carrier protein Aralar/Citrin (contains EF-hand Ca2+-binding domains) C Energy production and conversion ; IPR002048 [EF-hand domain] ; IPR018108[Mitochondrial substrate/solute carrier] -- -- P08752 Guanine nucleotide-binding protein G(i) subunit alpha-2 Gnai2 3989.9 4253.1 4440 4290.8 4315.6 4304.2 0.982371074930677 0.620106303448257 -0.0256600124655243 Nonsignificant None 5 Molecular Function:GTPase activity (GO:0003924),Molecular Function:signal transducer activity (GO:0004871),Biological Process:G-protein coupled receptor signaling pathway (GO:0007186),Molecular Function:guanyl nucleotide binding (GO:0019001),Molecular Function:G-protein beta/gamma-subunit complex binding (GO:0031683) guanine nucleotide-binding protein G(i) subunit alpha -- ko04015 Rap1 signaling pathway ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04062 Chemokine signaling pathway ko04071 Sphingolipid signaling pathway ko04261 Adrenergic signaling in cardiomyocytes ko04360 Axon guidance ko04371 Apelin signaling pathway ko04540 Gap junction ko04611 Platelet activation ko04670 Leukocyte transendothelial migration ko04713 Circadian entrainment ko04723 Retrograde endocannabinoid signaling ko04724 Glutamatergic synapse ko04725 Cholinergic synapse ko04726 Serotonergic synapse ko04727 GABAergic synapse ko04728 Dopaminergic synapse ko04730 Long-term depression ko04914 Progesterone-mediated oocyte maturation ko04915 Estrogen signaling pathway ko04916 Melanogenesis ko04921 Oxytocin signaling pathway ko04923 Regulation of lipolysis in adipocytes ko04924 Renin secretion ko04926 Relaxin signaling pathway ko04971 Gastric acid secretion ko05012 Parkinson's disease ko05030 Cocaine addiction ko05032 Morphine addiction ko05034 Alcoholism ko05133 Pertussis ko05142 Chagas disease (American trypanosomiasis) ko05145 Toxoplasmosis ko05200 Pathways in cancer G-protein alpha subunit (small G protein superfamily) DT Cell cycle control, cell division, chromosome partitioning ; Signal transduction mechanisms ; IPR001019 [Guanine nucleotide binding protein (G-protein), alpha subunit] -- -- B2RXY7 Carbonyl reductase (NADPH) Cbr1 6638.8 6297.9 7543.1 9825.7 10068.1 10285.2 0.678610954637331 0.00120784220087431 -0.559343375605656 Nonsignificant None -- -- -- -- ko00590 Arachidonic acid metabolism ko00790 Folate biosynthesis ko00980 Metabolism of xenobiotics by cytochrome P450 ko01100 Metabolic pathways ko05204 Chemical carcinogenesis Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Q Secondary metabolites biosynthesis, transport and catabolism ; IPR002347 [Short-chain dehydrogenase/reductase SDR] -- -- Q9Z2I0 Mitochondrial proton/calcium exchanger protein Letm1 4652.8 4394.7 5172.8 5510.5 5653.3 5386.1 0.859237820168098 0.0324162525438104 -0.218870598575068 Nonsignificant None -- -- LETM1 and EF-hand domain-containing protein 1, mitochondrial -- Ca2+-binding transmembrane protein LETM1/MRS7 S Function unknown ; IPR011685 [LETM1-like] -- -- P17426 AP-2 complex subunit alpha-1 Ap2a1 4405.2 4402.8 4893.4 4810.8 4806.5 4915 0.942823916379375 0.172452012747881 -0.0849397393494627 Nonsignificant None 4 Biological Process:intracellular protein transport (GO:0006886),Biological Process:vesicle-mediated transport (GO:0016192),Cellular Component:membrane coat (GO:0030117),Cellular Component:clathrin adaptor complex (GO:0030131) AP-2 complex subunit alpha -- ko04144 Endocytosis ko04721 Synaptic vesicle cycle ko04961 Endocrine and other factor-regulated calcium reabsorption ko05016 Huntington's disease Vesicle coat complex AP-2, alpha subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR002553 [Clathrin/coatomer adaptor, adaptin-like, N-terminal] ; IPR003164[Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain] ; IPR008152[Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain] -- -- O08663 Methionine aminopeptidase 2 Metap2 4110.1 4000.4 4251.5 4188.4 4440.5 3921.3 0.98500422304027 0.725615933520648 -0.0217981849922619 Nonsignificant None -- -- methionyl aminopeptidase 3.4.11.18 -- Metallopeptidase R General function prediction only ; IPR000994 [Peptidase M24] -- -- F8WJ05 Inter-alpha-trypsin inhibitor heavy chain H1 Itih1 7406.6 7965.5 4900.8 3267.4 3342.8 3408.6 2.02348584660838 0.0680447467392756 1.0168427580267 Nonsignificant None 2 Molecular Function:serine-type endopeptidase inhibitor activity (GO:0004867),Biological Process:hyaluronan metabolic process (GO:0030212) inter-alpha-trypsin inhibitor heavy chain H1 -- -- -- -- -- IPR002035 [von Willebrand factor, type A] ; IPR010600[Inter-alpha-trypsin inhibitor heavy chain, C-terminal] ; IPR013694[VIT domain] -- -- Q99KE1 NAD-dependent malic enzyme, mitochondrial Me2 5135.6 4869.4 5089.3 6190.3 6609.4 6183.4 0.795144101859022 0.00135573354097496 -0.330711754995876 Nonsignificant None 3 Molecular Function:malate dehydrogenase (decarboxylating) (NAD+) activity (GO:0004471),Molecular Function:NAD binding (GO:0051287),Biological Process:oxidation-reduction process (GO:0055114) malate dehydrogenase (oxaloacetate-decarboxylating) 1.1.1.38 ko00620 Pyruvate metabolism ko01200 Carbon metabolism NADP+-dependent malic enzyme C Energy production and conversion ; IPR012301 [Malic enzyme, N-terminal domain] ; IPR012302[Malic enzyme, NAD-binding] -- -- Q9ET01 Glycogen phosphorylase, liver form Pygl 4729.1 5765.7 4389.2 3550.1 3554.4 3565.1 1.39499137737122 0.0769347014412692 0.480256204590504 Nonsignificant None 2 Biological Process:carbohydrate metabolic process (GO:0005975),Molecular Function:glycogen phosphorylase activity (GO:0008184) glycogen phosphorylase 2.4.1.1 ko00500 Starch and sucrose metabolism ko01100 Metabolic pathways ko04217 Necroptosis ko04910 Insulin signaling pathway ko04922 Glucagon signaling pathway ko04931 Insulin resistance Glycogen phosphorylase G Carbohydrate transport and metabolism ; IPR000811 [Glycosyl transferase, family 35] -- -- P52825 Carnitine O-palmitoyltransferase 2, mitochondrial Cpt2 26.3 26.7 25.6 27.3 27.6 24.8 0.986198243412798 0.71749046657572 -0.0200504117318654 Nonsignificant None -- -- carnitine O-palmitoyltransferase 2 2.3.1.21 ko00071 Fatty acid degradation ko01212 Fatty acid metabolism ko03320 PPAR signaling pathway Carnitine O-acyltransferase CPT2/YAT1 I Lipid transport and metabolism ; IPR000542 [Acyltransferase ChoActase/COT/CPT] -- -- Q8BIJ6 Isoleucine--tRNA ligase, mitochondrial Iars2 5061.3 5094 5779.2 6339.9 6222.8 6387.4 0.840866275112005 0.0136501159775582 -0.250051711258943 Nonsignificant None 4 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation for protein translation (GO:0006418) isoleucyl-tRNA synthetase 6.1.1.5 ko00970 Aminoacyl-tRNA biosynthesis Isoleucyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR002300 [Aminoacyl-tRNA synthetase, class Ia] ; IPR013155[Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding] -- -- Q6IRU2 Tropomyosin alpha-4 chain Tpm4 8358.6 8324 5423.4 5118.7 5263.4 5677 1.37654040388316 0.110659591018658 0.461046956193111 Nonsignificant None -- -- tropomyosin 4 -- ko04260 Cardiac muscle contraction ko04261 Adrenergic signaling in cardiomyocytes ko05410 Hypertrophic cardiomyopathy (HCM) ko05414 Dilated cardiomyopathy (DCM) Actin filament-coating protein tropomyosin Z Cytoskeleton ; IPR000533 [Tropomyosin] -- -- Q8K4L3 Supervillin Svil 4933.8 5069.2 5690.7 5621.8 5533 5414.4 0.947160997513459 0.291977600078646 -0.0783184204369949 Nonsignificant None 2 Molecular Function:actin binding (GO:0003779),Biological Process:cytoskeleton organization (GO:0007010) supervillin -- -- Actin regulatory protein supervillin (gelsolin/villin family) Z Cytoskeleton ; IPR003128 [Villin headpiece] ; IPR007123[Gelsolin-like domain] -- -- D3Z5J3 Sorbin and SH3 domain-containing protein 1 Sorbs1 68.4 62.3 87.4 122.5 135.6 109.7 0.592985318107667 0.00935240965141398 -0.753931709771187 Significant down 1 Molecular Function:protein binding (GO:0005515) sorbin and SH3 domain containing 1 -- ko03320 PPAR signaling pathway ko04520 Adherens junction ko04910 Insulin signaling pathway Sorbin and SH3 domain-containing protein T Signal transduction mechanisms ; IPR001452 [SH3 domain] ; IPR003127[SoHo domain] ; IPR011511[Variant SH3 domain] -- -- P43406 Integrin alpha-V Itgav 5577 5662.7 5571.7 5832.1 5800.5 5726.4 0.968454404055533 0.013233595284917 -0.0462439681976729 Nonsignificant None -- -- integrin alpha V -- ko04145 Phagosome ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04514 Cell adhesion molecules (CAMs) ko04810 Regulation of actin cytoskeleton ko04919 Thyroid hormone signaling pathway ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05222 Small cell lung cancer ko05410 Hypertrophic cardiomyopathy (HCM) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05414 Dilated cardiomyopathy (DCM) ko05418 Fluid shear stress and atherosclerosis Vitronectin receptor, alpha subunit W Extracellular structures ; IPR013517 [FG-GAP repeat] ; IPR013649[Integrin alpha-2] ; IPR018184[Integrin alpha chain, C-terminal cytoplasmic region, conserved site] -- -- Q3U1C2 RuvB-like helicase Ruvbl1 4950.7 4924.4 5176.9 5129.7 5207.8 5128.4 0.973237897568198 0.177189416703056 -0.039135595440057 Nonsignificant None 2 Molecular Function:DNA helicase activity (GO:0003678),Molecular Function:ATP binding (GO:0005524) RuvB-like protein 1 (pontin 52) -- ko04310 Wnt signaling pathway DNA helicase, TBP-interacting protein L Replication, recombination and repair ; IPR010339 [TIP49, C-terminal] -- -- Q3TZZ7 Extended synaptotagmin-2 Esyt2 3374.6 3626.1 3874.9 3928.9 3928.1 3916 0.92377473880914 0.174046509976529 -0.114386999548076 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:lipid binding (GO:0008289) -- -- -- Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain R General function prediction only ; IPR000008 [C2 domain] ; IPR031468[Synaptotagmin-like mitochondrial-lipid-binding domain] -- -- P10630 Eukaryotic initiation factor 4A-II Eif4a2 1086.6 1124.3 630.8 757.3 693.5 675.2 1.33664158043274 0.269991013873774 0.418612659556365 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) translation initiation factor 4A -- ko03013 RNA transport Translation initiation factor 4F, helicase subunit (eIF-4A) and related helicases J Translation, ribosomal structure and biogenesis ; IPR001650 [Helicase, C-terminal] ; IPR011545[DEAD/DEAH box helicase domain] -- -- Q9EQH2 Endoplasmic reticulum aminopeptidase 1 Erap1 4246.3 4245.9 4895 4810.4 4931.3 4707.4 0.926507533341177 0.191995773755237 -0.110125388176351 Nonsignificant None 2 Molecular Function:metallopeptidase activity (GO:0008237),Molecular Function:zinc ion binding (GO:0008270) adipocyte-derived leucine aminopeptidase 3.4.11.- -- Puromycin-sensitive aminopeptidase and related aminopeptidases EO Amino acid transport and metabolism ; Posttranslational modification, protein turnover, chaperones ; IPR014782 [Peptidase M1, membrane alanine aminopeptidase, N-terminal] ; IPR024571[ERAP1-like C-terminal domain] -- -- P51432 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 Plcb3 5963.8 5692.5 7917.9 6682 6806.6 6975.9 0.956495394463583 0.714096917526565 -0.0641700728926034 Nonsignificant None 7 Molecular Function:phosphatidylinositol phospholipase C activity (GO:0004435),Molecular Function:calcium ion binding (GO:0005509),Molecular Function:protein binding (GO:0005515),Biological Process:lipid metabolic process (GO:0006629),Biological Process:signal transduction (GO:0007165),Biological Process:lipid catabolic process (GO:0016042),Biological Process:intracellular signal transduction (GO:0035556) phosphatidylinositol phospholipase C, beta 3.1.4.11 ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04015 Rap1 signaling pathway ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04062 Chemokine signaling pathway ko04070 Phosphatidylinositol signaling system ko04071 Sphingolipid signaling pathway ko04072 Phospholipase D signaling pathway ko04261 Adrenergic signaling in cardiomyocytes ko04270 Vascular smooth muscle contraction ko04310 Wnt signaling pathway ko04371 Apelin signaling pathway ko04540 Gap junction ko04611 Platelet activation ko04621 NOD-like receptor signaling pathway ko04713 Circadian entrainment ko04720 Long-term potentiation ko04723 Retrograde endocannabinoid signaling ko04724 Glutamatergic synapse ko04725 Cholinergic synapse ko04726 Serotonergic synapse ko04728 Dopaminergic synapse ko04730 Long-term depression ko04750 Inflammatory mediator regulation of TRP channels ko04911 Insulin secretion ko04912 GnRH signaling pathway ko04915 Estrogen signaling pathway ko04916 Melanogenesis ko04918 Thyroid hormone synthesis ko04919 Thyroid hormone signaling pathway ko04921 Oxytocin signaling pathway ko04922 Glucagon signaling pathway ko04924 Renin secretion ko04925 Aldosterone synthesis and secretion ko04926 Relaxin signaling pathway ko04933 AGE-RAGE signaling pathway in diabetic complications ko04961 Endocrine and other factor-regulated calcium reabsorption ko04970 Salivary secretion ko04971 Gastric acid secretion ko04972 Pancreatic secretion ko05010 Alzheimer's disease ko05016 Huntington's disease ko05142 Chagas disease (American trypanosomiasis) ko05143 African trypanosomiasis ko05146 Amoebiasis ko05200 Pathways in cancer Phospholipase C I Lipid transport and metabolism ; IPR000008 [C2 domain] ; IPR000909[Phosphatidylinositol-specific phospholipase C, X domain] ; IPR001711[Phospholipase C, phosphatidylinositol-specific, Y domain] ; IPR014815[Phospholipase C-beta, C-terminal domain] ; IPR015359[Phosphoinositide-specific phospholipase C, EF-hand-like domain] -- -- A0A668KLV9 A-kinase anchor protein 12 Akap12 3458.8 3599.6 4302.6 4051.2 4248.4 3878.3 0.932919468873944 0.388977012657665 -0.100175544218214 Nonsignificant None 2 Biological Process:protein targeting (GO:0006605),Biological Process:signal transduction (GO:0007165) A-kinase anchor protein 12 -- -- -- -- -- IPR001573 [Protein kinase A anchoring, WSK motif] ; IPR018459[RII binding domain] -- -- E9QB02 Methionine--tRNA ligase, cytoplasmic Mars1 5853.7 5591.1 5560.7 5284 5498.4 5339.3 1.05482052140903 0.0596837311720608 0.0769975440502737 Nonsignificant None 4 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation for protein translation (GO:0006418) methionyl-tRNA synthetase 6.1.1.10 ko00450 Selenocompound metabolism ko00970 Aminoacyl-tRNA biosynthesis Methionyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR000738 [WHEP-TRS domain] ; IPR004046[Glutathione S-transferase, C-terminal] ; IPR015413[Methionyl/Leucyl tRNA synthetase] -- -- Q5SQB7 Nucleophosmin Npm1 10639.9 11218.6 9549.9 7066.9 7265 7164.1 1.46112765165612 0.0200558581642717 0.54708222493561 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) nucleophosmin 1 -- -- -- -- -- IPR024057 [Nucleoplasmin core domain] ; IPR032569[Nucleophosmin, C-terminal] -- -- Q9CZN7 Serine hydroxymethyltransferase, mitochondrial Shmt2 5694.1 5728.7 5139.3 4034.3 4413.9 4090.5 1.32087855997831 0.00395333465415504 0.401497832996021 Nonsignificant None 1 Molecular Function:transferase activity (GO:0016740) glycine hydroxymethyltransferase 2.1.2.1 ko00260 Glycine, serine and threonine metabolism ko00630 Glyoxylate and dicarboxylate metabolism ko00670 One carbon pool by folate ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids ko01523 Antifolate resistance Glycine/serine hydroxymethyltransferase E Amino acid transport and metabolism ; IPR001085 [Serine hydroxymethyltransferase] -- -- Q8CFK5 Lysine--tRNA ligase Kars 8694.7 8314.3 8615.2 8898.4 9156.2 8849.2 0.952437945569027 0.0466487488211027 -0.0703029954952703 Nonsignificant None 5 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation for protein translation (GO:0006418) lysyl-tRNA synthetase, class II 6.1.1.6 ko00970 Aminoacyl-tRNA biosynthesis Lysyl-tRNA synthetase (class II) J Translation, ribosomal structure and biogenesis ; IPR004364 [Aminoacyl-tRNA synthetase, class II (D/K/N)] ; IPR004365[OB-fold nucleic acid binding domain, AA-tRNA synthetase-type] -- -- Q9D0R2 Threonine--tRNA ligase 1, cytoplasmic Tars1 8056.7 7778.7 8131.6 7745.2 7790.1 7691.9 1.03185058896466 0.0905268657620381 0.0452340849423338 Nonsignificant None 5 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation for protein translation (GO:0006418),Biological Process:tRNA aminoacylation (GO:0043039) threonyl-tRNA synthetase 6.1.1.3 ko00970 Aminoacyl-tRNA biosynthesis Threonyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR002314 [Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)] ; IPR004095[TGS] ; IPR004154[Anticodon-binding] ; IPR012947[Threonyl/alanyl tRNA synthetase, SAD] -- -- Q9CPV4 Glyoxalase domain-containing protein 4 Glod4 5786.3 5829.1 6499 6635.2 6637.7 7171.2 0.886045362720785 0.0562027023074746 -0.174547532792157 Nonsignificant None -- -- -- -- -- Predicted glyoxalase G Carbohydrate transport and metabolism ; -- -- -- Q8BMF4 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Dlat 3272.4 3287.1 3765.5 4441.2 4222.7 4465.2 0.786421003724551 0.00647170311314115 -0.346626241209131 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) 2.3.1.12 ko00010 Glycolysis / Gluconeogenesis ko00020 Citrate cycle (TCA cycle) ko00620 Pyruvate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism Dihydrolipoamide acetyltransferase C Energy production and conversion ; IPR000089 [Biotin/lipoyl attachment] ; IPR001078[2-oxoacid dehydrogenase acyltransferase, catalytic domain] ; IPR004167[E3-binding domain] -- -- Q64514 Tripeptidyl-peptidase 2 Tpp2 7105.2 7206.6 7378.5 6821.6 7144.5 6835.1 1.04274272638117 0.0884853604634992 0.0603832487887174 Nonsignificant None 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) tripeptidyl-peptidase II 3.4.14.10 -- Tripeptidyl peptidase II O Posttranslational modification, protein turnover, chaperones ; IPR000209 [Peptidase S8/S53 domain] ; IPR022229[Peptidase S8A, tripeptidyl peptidase II] -- -- Q52L50 RAS related protein 1b Rap1b 2144.6 2229.6 2638.7 2325.3 2520.1 2455.5 0.960552808557849 0.587375600554859 -0.0580631634013276 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rap-1B -- ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04024 cAMP signaling pathway ko04062 Chemokine signaling pathway ko04510 Focal adhesion ko04611 Platelet activation ko04670 Leukocyte transendothelial migration ko04720 Long-term potentiation ko04722 Neurotrophin signaling pathway ko04972 Pancreatic secretion ko05211 Renal cell carcinoma Ras-related GTPase R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- B2RXS4 Plexin-B2 Plxnb2 4737.4 4558.6 4793.6 5092.7 5170.7 5237.8 0.908936082367817 0.00463559704507796 -0.137749249195368 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:membrane (GO:0016020) plexin B -- ko04360 Axon guidance Plexins (functional semaphorin receptors) T Signal transduction mechanisms ; IPR001627 [Sema domain] ; IPR002165[Plexin repeat] ; IPR002909[IPT domain] ; IPR013548[Plexin, cytoplasmic RasGAP domain] -- -- A0A0R4J140 Clustered mitochondria protein homolog Cluh 4382.7 4247.2 4517 4104.1 4017.9 4072.3 1.07811846518455 0.0178495953489309 0.108515712175818 Nonsignificant None -- -- protein TIF31 -- -- Uncharacterized protein CLU1/cluA/TIF31 involved in mitochondrial morphology/distribution, also found associated with eIF-3 R General function prediction only ; IPR025697 [CLU domain] ; IPR028275[Clustered mitochondria protein, N-terminal] ; IPR033646[CLU central domain] -- -- P97384 Annexin A11 Anxa11 7726.6 7510.9 6043.5 7250 7089.3 7030.6 0.995839943097534 0.960569263408946 -0.00601421188646014 Nonsignificant None 2 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:calcium-dependent phospholipid binding (GO:0005544) annexin A7/11 -- -- Annexin U Intracellular trafficking, secretion, and vesicular transport ; IPR018502 [Annexin repeat] -- -- P24369 Peptidyl-prolyl cis-trans isomerase B Ppib 11107 10977.5 11428.1 10732.8 10725.9 10768.8 1.03987588239857 0.0840096777270561 0.0564113413144438 Nonsignificant None 3 Biological Process:protein peptidyl-prolyl isomerization (GO:0000413),Molecular Function:peptidyl-prolyl cis-trans isomerase activity (GO:0003755),Biological Process:protein folding (GO:0006457) peptidyl-prolyl cis-trans isomerase B (cyclophilin B) 5.2.1.8 -- Peptidyl-prolyl cis-trans isomerase O Posttranslational modification, protein turnover, chaperones ; IPR002130 [Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain] -- -- Q80VA0 N-acetylgalactosaminyltransferase 7 Galnt7 7118.9 6539.2 8553.9 9247.9 8797.9 9170.4 0.816131568698055 0.0533384812840782 -0.29312634684811 Nonsignificant None -- -- polypeptide N-acetylgalactosaminyltransferase 2.4.1.41 ko00512 Mucin type O-glycan biosynthesis ko01100 Metabolic pathways Predicted polypeptide N-acetylgalactosaminyltransferase O Posttranslational modification, protein turnover, chaperones ; IPR000772 [Ricin B, lectin domain] ; IPR001173[Glycosyltransferase 2-like] -- -- Q61033 Lamina-associated polypeptide 2, isoforms alpha/zeta Tmpo 1592.1 1590 1495.5 1493.5 1476.6 1510.5 1.04396732580458 0.120101991129359 0.0620765589984401 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) -- -- -- -- -- -- IPR003887 [LEM domain] ; IPR013146[LEM-like domain] ; IPR021623[Lamina-associated polypeptide 2 alpha] -- -- A0A0R4J0B4 N-acylneuraminate cytidylyltransferase Cmas 7333.4 7099.2 6830.9 8697.1 8366.8 9147.7 0.811224801233042 0.00357937181158514 -0.301826334966031 Nonsignificant None -- -- -- -- ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways -- -- -- IPR003329 [Acylneuraminate cytidylyltransferase] -- -- P32067 Lupus La protein homolog Ssb 11786.4 11300 9890.9 8910.2 8866.7 9086.7 1.22758304918179 0.0678128764714463 0.295820629908396 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:RNA binding (GO:0003723) lupus La protein -- ko05322 Systemic lupus erythematosus RNA-binding protein La A RNA processing and modification ; IPR000504 [RNA recognition motif domain] ; IPR006630[RNA-binding protein Lupus La] ; IPR014886[La protein, RNA-binding domain] -- -- G5E8R3 Pyruvate carboxylase Pcx 4876.8 4535.8 4549.9 6734.7 7090.2 6909.5 0.673397831622811 0.000118053924178046 -0.57046901926985 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Molecular Function:ATP binding (GO:0005524) pyruvate carboxylase 6.4.1.1 ko00020 Citrate cycle (TCA cycle) ko00620 Pyruvate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids Pyruvate carboxylase C Energy production and conversion ; IPR000089 [Biotin/lipoyl attachment] ; IPR000891[Pyruvate carboxyltransferase] ; IPR003379[Carboxylase, conserved domain] ; IPR005479[Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain] ; IPR005481[Biotin carboxylase-like, N-terminal domain] ; IPR005482[Biotin carboxylase, C-terminal] -- -- P06728 Apolipoprotein A-IV Apoa4 7233.4 7445.9 6237.2 4822.2 4911 4524 1.46708329826333 0.0047293817059651 0.552950786880242 Nonsignificant None 4 Cellular Component:extracellular region (GO:0005576),Biological Process:lipid transport (GO:0006869),Molecular Function:lipid binding (GO:0008289),Biological Process:lipoprotein metabolic process (GO:0042157) apolipoprotein A-IV -- ko04975 Fat digestion and absorption ko04977 Vitamin digestion and absorption ko04979 Cholesterol metabolism -- -- -- IPR000074 [Apolipoprotein A/E] -- -- A0A0R4IZW5 Cadherin-1 Cdh1 7305.8 6939.3 8550.6 8427 8854 8667.2 0.878507950455138 0.104957955579221 -0.186872752273179 Nonsignificant None 3 Molecular Function:calcium ion binding (GO:0005509),Biological Process:homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156),Cellular Component:membrane (GO:0016020) cadherin 1, type 1, E-cadherin -- ko04015 Rap1 signaling pathway ko04371 Apelin signaling pathway ko04390 Hippo signaling pathway ko04514 Cell adhesion molecules (CAMs) ko04520 Adherens junction ko05100 Bacterial invasion of epithelial cells ko05200 Pathways in cancer ko05213 Endometrial cancer ko05216 Thyroid cancer ko05218 Melanoma ko05219 Bladder cancer ko05226 Gastric cancer FOG: Cadherin repeats S Function unknown ; IPR000233 [Cadherin, cytoplasmic domain] ; IPR002126[Cadherin] ; IPR014868[Cadherin prodomain] -- -- P84084 ADP-ribosylation factor 5 Arf5 1969.5 2007.7 2319.5 2571.8 2500.8 2426.6 0.839649562620013 0.0277279670765746 -0.252140766709282 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) ADP-ribosylation factor 5 -- ko04144 Endocytosis GTP-binding ADP-ribosylation factor Arf1 U Intracellular trafficking, secretion, and vesicular transport ; IPR006689 [Small GTPase superfamily, ARF/SAR type] -- -- Q9D1A2 Cytosolic non-specific dipeptidase Cndp2 3699.3 3738 4125.7 4451.3 4527.9 4431 0.86225410508419 0.0115099541775937 -0.213815002693834 Nonsignificant None 2 Biological Process:metabolic process (GO:0008152),Molecular Function:hydrolase activity (GO:0016787) cytosolic nonspecific dipeptidase 3.4.13.18 ko00330 Arginine and proline metabolism ko00340 Histidine metabolism ko00410 beta-Alanine metabolism ko01100 Metabolic pathways Metalloexopeptidases E Amino acid transport and metabolism ; IPR002933 [Peptidase M20] ; IPR011650[Peptidase M20, dimerisation domain] -- -- Q5BKQ9 Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 11 Psmd11 6049.7 6208.2 6253.7 5675.8 5837.7 5547.1 1.08504976378322 0.00977294818657278 0.117761210703758 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) 26S proteasome regulatory subunit N6 -- ko03050 Proteasome ko05169 Epstein-Barr virus infection 26S proteasome regulatory complex, subunit RPN6/PSMD11 O Posttranslational modification, protein turnover, chaperones ; IPR000717 [Proteasome component (PCI) domain] -- -- Q6ZWQ0 Nesprin-2 Syne2 1914.2 1856 2152.1 2148 2094.9 2169.9 0.923512350299401 0.154474283326086 -0.114796840126255 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:integral component of membrane (GO:0016021) nesprin-2 -- -- Dystonin, GAS (Growth-arrest-specific protein), and related proteins Z Cytoskeleton ; IPR001715 [Calponin homology domain] ; IPR002017[Spectrin repeat] ; IPR012315[KASH domain] -- -- A0A0R4J111 Glutathione peroxidase Gpx2 7003.6 6861.7 5871.5 5639.9 6381.4 6039.3 1.09280976268784 0.249975583139611 0.12804227720918 Nonsignificant None 3 Molecular Function:glutathione peroxidase activity (GO:0004602),Biological Process:response to oxidative stress (GO:0006979),Biological Process:oxidation-reduction process (GO:0055114) glutathione peroxidase 1.11.1.9 ko00480 Glutathione metabolism ko00590 Arachidonic acid metabolism ko04918 Thyroid hormone synthesis Glutathione peroxidase O Posttranslational modification, protein turnover, chaperones ; IPR000889 [Glutathione peroxidase] -- -- P61205 ADP-ribosylation factor 3 Arf3 816.3 701.7 714.4 860.3 841.3 932.7 0.847435751433018 0.0428222597675853 -0.238824100800717 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) ADP-ribosylation factor 3 -- ko04144 Endocytosis GTP-binding ADP-ribosylation factor Arf1 U Intracellular trafficking, secretion, and vesicular transport ; IPR006689 [Small GTPase superfamily, ARF/SAR type] -- -- Q9CQA3 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Sdhb 6756.6 6798.7 9005.3 10834.2 10729.4 10828.2 0.696491087250477 0.0474423652674078 -0.521823203599685 Nonsignificant None 2 Molecular Function:electron carrier activity (GO:0009055),Molecular Function:iron-sulfur cluster binding (GO:0051536) succinate dehydrogenase (ubiquinone) iron-sulfur subunit 1.3.5.1 ko00020 Citrate cycle (TCA cycle) ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko01200 Carbon metabolism ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Succinate dehydrogenase, Fe-S protein subunit C Energy production and conversion ; IPR025192 [Succinate dehydogenase/fumarate reductase N-terminal] -- -- Q8VCT3 Aminopeptidase B Rnpep 4880.7 4792.6 5057.7 4920.5 5130 4914.7 0.984350359500708 0.499693569387551 -0.0227561899437016 Nonsignificant None 2 Molecular Function:metallopeptidase activity (GO:0008237),Molecular Function:zinc ion binding (GO:0008270) aminopeptidase B 3.4.11.6 -- Bifunctional leukotriene A4 hydrolase/aminopeptidase LTA4H IOVE Lipid transport and metabolism ; Posttranslational modification, protein turnover, chaperones ; Defense mechanisms ; Amino acid transport and metabolism ; IPR014782 [Peptidase M1, membrane alanine aminopeptidase, N-terminal] ; IPR015211[Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal] -- -- A1ILG8 Chorein Vps13c 2761.1 2683.3 2700.8 3311.2 3334.5 3125.5 0.833592598657279 0.00151501905604751 -0.262585626685341 Nonsignificant None -- -- vacuolar protein sorting-associated protein 13A/C -- -- Vacuolar protein sorting-associated protein U Intracellular trafficking, secretion, and vesicular transport ; IPR009543 [Vacuolar protein sorting-associated protein 13, SHR-binding domain] ; IPR015412[Autophagy-related, C-terminal] ; IPR026854[Vacuolar protein sorting-associated protein 13, N-terminal domain] ; IPR031642[VPS13, repeated coiled region] ; IPR031645[Vacuolar protein sorting-associated protein 13, C-terminal] ; IPR031646[Vacuolar protein sorting-associated protein 13, second N-terminal domain] -- -- A0A0R4J0G0 Phosphoenolpyruvate carboxykinase (GTP) Pck2 3135.5 2960.4 3293.2 3622.6 3642.3 3766.7 0.85110953986729 0.00671367973145824 -0.232583272666734 Nonsignificant None 3 Molecular Function:phosphoenolpyruvate carboxykinase activity (GO:0004611),Molecular Function:GTP binding (GO:0005525),Biological Process:gluconeogenesis (GO:0006094) phosphoenolpyruvate carboxykinase (GTP) 4.1.1.32 ko00010 Glycolysis / Gluconeogenesis ko00020 Citrate cycle (TCA cycle) ko00620 Pyruvate metabolism ko01100 Metabolic pathways ko03320 PPAR signaling pathway ko04068 FoxO signaling pathway ko04151 PI3K-Akt signaling pathway ko04152 AMPK signaling pathway ko04910 Insulin signaling pathway ko04920 Adipocytokine signaling pathway ko04922 Glucagon signaling pathway ko04931 Insulin resistance ko04964 Proximal tubule bicarbonate reclamation Phosphoenolpyruvate carboxykinase C Energy production and conversion ; IPR008209 [Phosphoenolpyruvate carboxykinase, GTP-utilising] -- -- Q64521 Glycerol-3-phosphate dehydrogenase, mitochondrial Gpd2 5323.3 5084.3 5224.2 5798.5 6026.8 5723.1 0.890782065601422 0.00508054731750596 -0.166855582707271 Nonsignificant None 3 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) glycerol-3-phosphate dehydrogenase 1.1.5.3 ko00564 Glycerophospholipid metabolism Glycerol-3-phosphate dehydrogenase C Energy production and conversion ; IPR002048 [EF-hand domain] ; IPR006076[FAD dependent oxidoreductase] ; IPR031656[Alpha-glycerophosphate oxidase, C-terminal] -- -- Q8BUM1 TAR DNA-binding protein 43 Tardbp 5754.5 5697.5 5793.5 5314.7 5242.2 5516.2 1.0729417473916 0.0107080994064844 0.101571750809628 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- -- -- -- IPR000504 [RNA recognition motif domain] -- -- B1AU25 Apoptosis-inducing factor 1, mitochondrial Aifm1 3456.7 3165.2 3628.1 4682.3 4256.2 4465.5 0.764697105341689 0.00452506023466691 -0.3870396819243 Nonsignificant None 3 Molecular Function:oxidoreductase activity (GO:0016491),Molecular Function:protein dimerization activity (GO:0046983),Biological Process:oxidation-reduction process (GO:0055114) programmed cell death 8 (apoptosis-inducing factor) 1.-.-.- ko04210 Apoptosis ko04217 Necroptosis Programmed cell death 8 (apoptosis-inducing factor) T Signal transduction mechanisms ; IPR023753 [FAD/NAD(P)-binding domain] ; IPR029324[Mitochondrial apoptosis-inducing factor, C-terminal domain] ; IPR032773[Protein MGARP, N-terminal] -- -- Q3TPZ5 Uncharacterized protein Dctn2 3553.4 3385.5 3840.8 3709.1 3735.8 3726.3 0.964954525923804 0.429818883278644 -0.051467138796837 Nonsignificant None -- -- dynactin 2 -- ko04962 Vasopressin-regulated water reabsorption ko05016 Huntington's disease Putative dynamitin Z Cytoskeleton ; -- -- -- E9PYI8 Ubiquitin carboxyl-terminal hydrolase Usp14 5354.7 5107.4 4570.8 4087.8 4281.9 4291.5 1.18732031718952 0.0303734708381997 0.247709200084697 Nonsignificant None 2 Biological Process:protein deubiquitination (GO:0016579),Molecular Function:thiol-dependent ubiquitinyl hydrolase activity (GO:0036459) ubiquitin carboxyl-terminal hydrolase 14 3.4.19.12 -- Ubiquitin-specific protease O Posttranslational modification, protein turnover, chaperones ; IPR001394 [Peptidase C19, ubiquitin carboxyl-terminal hydrolase] -- -- Q3THE7 Aldedh domain-containing protein Aldh9a1 4990.2 4851.2 5602 5396.1 5168.3 5134.3 0.983737506927325 0.745664279222268 -0.0236546858005953 Nonsignificant None 3 Biological Process:metabolic process (GO:0008152),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00010 Glycolysis / Gluconeogenesis ko00053 Ascorbate and aldarate metabolism ko00071 Fatty acid degradation ko00280 Valine, leucine and isoleucine degradation ko00310 Lysine degradation ko00330 Arginine and proline metabolism ko00340 Histidine metabolism ko00380 Tryptophan metabolism ko00410 beta-Alanine metabolism ko00561 Glycerolipid metabolism ko00620 Pyruvate metabolism ko01100 Metabolic pathways Aldehyde dehydrogenase C Energy production and conversion ; IPR015590 [Aldehyde dehydrogenase domain] -- -- Q60710 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Samhd1 6470.6 6872.1 6924.6 6646.6 6856.7 6648.4 1.00573648873296 0.820918413653992 0.00825235663728165 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) Metal-dependent phosphohydrolase S Function unknown ; IPR001660 [Sterile alpha motif domain] ; IPR006674[HD domain] -- -- Q91YH5 Atlastin-3 Atl3 4831.9 4896.4 5586.8 5872.8 5739.4 5789.8 0.880077002643374 0.0467415102161055 -0.184298336510607 Nonsignificant None 2 Molecular Function:GTPase activity (GO:0003924),Molecular Function:GTP binding (GO:0005525) atlastin 3.6.5.- -- Guanylate-binding protein R General function prediction only ; IPR003191 [Guanylate-binding protein, C-terminal] ; IPR015894[Guanylate-binding protein, N-terminal] -- -- P10639 Thioredoxin Txn 10439.2 10517.1 8329.7 10283 10440.1 10475 0.93871101124748 0.467773820744295 -0.0912470124181366 Nonsignificant None 1 Biological Process:cell redox homeostasis (GO:0045454) thioredoxin 1 -- ko04621 NOD-like receptor signaling pathway ko05418 Fluid shear stress and atherosclerosis Thioredoxin O Posttranslational modification, protein turnover, chaperones ; IPR013766 [Thioredoxin domain] -- -- B2RRH9 GMP synthase (glutamine-hydrolyzing) Gmps 5329.1 5374.6 5118.1 4625.4 4675.7 4732.1 1.12745489268307 0.00215778012519639 0.173069715162061 Nonsignificant None 4 Molecular Function:GMP synthase (glutamine-hydrolyzing) activity (GO:0003922),Molecular Function:ATP binding (GO:0005524),Biological Process:purine nucleotide biosynthetic process (GO:0006164),Biological Process:GMP biosynthetic process (GO:0006177) GMP synthase (glutamine-hydrolysing) 6.3.5.2 ko00230 Purine metabolism ko00983 Drug metabolism - other enzymes ko01100 Metabolic pathways GMP synthase F Nucleotide transport and metabolism ; IPR001674 [GMP synthase, C-terminal] ; IPR017926[Glutamine amidotransferase] ; IPR022310[NAD/GMP synthase] -- -- Z4YL78 Cytoskeleton-associated protein 5 Ckap5 7348 7144.7 6367.4 5924.9 6151.8 6189.5 1.14200545269405 0.0493643436885887 0.191569539103453 Nonsignificant None -- -- cytoskeleton-associated protein 5 -- -- Microtubule-associated protein Z Cytoskeleton ; IPR024395 [CLASP N-terminal domain] -- -- Q3UDA8 Carn_acyltransf domain-containing protein Cpt2 135.2 121.7 141.8 162.6 152.5 155 0.848117421825144 0.0231817936824605 -0.237664075196406 Nonsignificant None -- -- carnitine O-palmitoyltransferase 2 2.3.1.21 ko00071 Fatty acid degradation ko01212 Fatty acid metabolism ko03320 PPAR signaling pathway Carnitine O-acyltransferase CPT2/YAT1 I Lipid transport and metabolism ; IPR000542 [Acyltransferase ChoActase/COT/CPT] -- -- Q54AA2 Apoptosis-associated speck-like protein containing CARD Pycard 4085.4 3690.7 5334.6 4937.4 5119.1 4954.6 0.873400350407365 0.328981763431948 -0.195284984961241 Nonsignificant None 1 Biological Process:regulation of apoptotic process (GO:0042981) apoptosis-associated speck-like protein containing a CARD -- ko04217 Necroptosis ko04621 NOD-like receptor signaling pathway ko04623 Cytosolic DNA-sensing pathway ko05132 Salmonella infection ko05133 Pertussis ko05134 Legionellosis ko05164 Influenza A -- -- -- IPR001315 [CARD domain] ; IPR004020[DAPIN domain] -- -- P16045 Galectin-1 Lgals1 12898.3 14260.5 14659.5 14549.2 14534 14375.8 0.962247175498746 0.412978258169555 -0.0555205636134546 Nonsignificant None 1 Molecular Function:carbohydrate binding (GO:0030246) galectin-1 -- -- Galectin, galactose-binding lectin W Extracellular structures ; IPR001079 [Galectin, carbohydrate recognition domain] -- -- Q8BT90 40S ribosomal protein S17 (Fragment) Rps17 8212 8414.6 7951.6 6935.6 7186.8 7149.7 1.15541954014883 0.00207750826297313 0.208416798472902 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S17e -- ko03010 Ribosome 40S ribosomal protein S17 J Translation, ribosomal structure and biogenesis ; IPR001210 [Ribosomal protein S17e] -- -- Q3V1Z5 40S ribosomal protein S4 Rps4l 58.8 47.9 49.5 52.3 63.5 61.5 0.880992667794698 0.219962969384039 -0.182798082756709 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) small subunit ribosomal protein S4e -- ko03010 Ribosome 40S ribosomal protein S4 J Translation, ribosomal structure and biogenesis ; IPR002942 [RNA-binding S4 domain] ; IPR005824[KOW] ; IPR013843[Ribosomal protein S4e, N-terminal] ; IPR013845[Ribosomal protein S4e, central region] ; IPR032277[40S ribosomal protein S4, C-terminal domain] -- -- Q9DB20 ATP synthase subunit O, mitochondrial Atp5po 7149.5 6603.5 7175.7 7711 7562.3 7686.7 0.911528745644599 0.0243547184756866 -0.133639941590596 Nonsignificant None 1 Biological Process:ATP synthesis coupled proton transport (GO:0015986) F-type H+-transporting ATPase subunit O -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Mitochondrial F1F0-ATP synthase, subunit OSCP/ATP5 C Energy production and conversion ; IPR000711 [ATPase, OSCP/delta subunit] -- -- Q3UIJ2 Protein-synthesizing GTPase Eif2s3x 8360.2 8655.7 6875.7 6178.3 6278.4 6760.3 1.2432533694125 0.0546674850777056 0.314120341076823 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) translation initiation factor 2 subunit 3 -- ko03013 RNA transport Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase) J Translation, ribosomal structure and biogenesis ; IPR004161 [Translation elongation factor EFTu-like, domain 2] ; IPR015256[Translation initiation factor 2, gamma subunit, C-terminal] -- -- Q3UDI8 DNA replication licensing factor MCM7 Mcm7 4748.5 4732.7 4401 3766.7 3869.2 3667.4 1.22815460971575 0.00251434521326573 0.296492189885338 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Molecular Function:ATP binding (GO:0005524),Biological Process:DNA replication (GO:0006260) DNA replication licensing factor MCM7 3.6.4.12 ko03030 DNA replication ko04110 Cell cycle DNA replication licensing factor, MCM7 component L Replication, recombination and repair ; IPR001208 [MCM domain] ; IPR027925[MCM N-terminal domain] ; IPR033762[MCM OB domain] -- -- Q8BL66 Early endosome antigen 1 Eea1 4967 4959.5 5134 5404.5 5574.4 5489 0.914536765464935 0.00335833842252354 -0.1288869256922 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) early endosome antigen 1 -- ko04144 Endocytosis ko04145 Phagosome ko05152 Tuberculosis -- -- -- IPR000306 [FYVE zinc finger] -- -- Q8VHY0 Chondroitin sulfate proteoglycan 4 Cspg4 2587.6 2576.1 2514.8 2565.7 2602.9 2404.8 1.01387751868381 0.617732783383913 0.0198833783172562 Nonsignificant None -- -- chondroitin sulfate proteoglycan 4 -- -- Proteoglycan R General function prediction only ; IPR001791 [Laminin G domain] -- -- Q91ZA3 Propionyl-CoA carboxylase alpha chain, mitochondrial Pcca 4788.1 4774.1 5515.1 6801.3 6291.2 6813 0.757443922533973 0.0057663256716012 -0.400789012475885 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) propionyl-CoA carboxylase alpha chain 6.4.1.3 ko00280 Valine, leucine and isoleucine degradation ko00630 Glyoxylate and dicarboxylate metabolism ko00640 Propanoate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism 3-Methylcrotonyl-CoA carboxylase, biotin-containing subunit/Propionyl-CoA carboxylase, alpha chain/Acetyl-CoA carboxylase, biotin carboxylase subunit IE Lipid transport and metabolism ; Amino acid transport and metabolism ; IPR000089 [Biotin/lipoyl attachment] ; IPR005479[Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain] ; IPR005481[Biotin carboxylase-like, N-terminal domain] ; IPR005482[Biotin carboxylase, C-terminal] -- -- Q3U8W0 Serine/threonine-protein phosphatase PP1-alpha catalytic subunit Ppp1ca 1361.6 1274.6 1175.7 1063.4 1050.5 1089.4 1.18999157119221 0.0209308892500656 0.250951354842237 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) serine/threonine-protein phosphatase PP1 catalytic subunit 3.1.3.16 ko03015 mRNA surveillance pathway ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04114 Oocyte meiosis ko04218 Cellular senescence ko04261 Adrenergic signaling in cardiomyocytes ko04270 Vascular smooth muscle contraction ko04390 Hippo signaling pathway ko04510 Focal adhesion ko04611 Platelet activation ko04720 Long-term potentiation ko04728 Dopaminergic synapse ko04750 Inflammatory mediator regulation of TRP channels ko04810 Regulation of actin cytoskeleton ko04910 Insulin signaling pathway ko04921 Oxytocin signaling pathway ko04931 Insulin resistance ko05031 Amphetamine addiction ko05034 Alcoholism ko05168 Herpes simplex infection ko05205 Proteoglycans in cancer Serine/threonine specific protein phosphatase PP1, catalytic subunit TR Signal transduction mechanisms ; General function prediction only ; IPR004843 [Calcineurin-like phosphoesterase domain, ApaH type] ; IPR031675[Serine-threonine protein phosphatase, N-terminal] -- -- A0A498WGK2 Asparagine--tRNA ligase Nars 7382.1 7332.3 7811.5 6551.3 7094.8 6754.6 1.10417289602808 0.0321533946673446 0.142966093051218 Nonsignificant None 5 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation for protein translation (GO:0006418) asparaginyl-tRNA synthetase 6.1.1.22 ko00970 Aminoacyl-tRNA biosynthesis Asparaginyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR004364 [Aminoacyl-tRNA synthetase, class II (D/K/N)] ; IPR004365[OB-fold nucleic acid binding domain, AA-tRNA synthetase-type] -- -- A7VMV2 L-gulonate 3-dehydrogenase Cryl1 2108.4 2017.5 2612.4 3391.8 3104.1 3500.3 0.67408615273804 0.00778254716912629 -0.568995105579773 Nonsignificant None 4 Molecular Function:3-hydroxyacyl-CoA dehydrogenase activity (GO:0003857),Biological Process:fatty acid metabolic process (GO:0006631),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) L-gulonate 3-dehydrogenase 1.1.1.45 ko00040 Pentose and glucuronate interconversions ko01100 Metabolic pathways 3-hydroxyacyl-CoA dehydrogenase I Lipid transport and metabolism ; IPR006108 [3-hydroxyacyl-CoA dehydrogenase, C-terminal] ; IPR006176[3-hydroxyacyl-CoA dehydrogenase, NAD binding] -- -- Q8C306 Uncharacterized protein (Fragment) 87.2 102.7 98.1 119.5 122 104.8 0.831648859370488 0.0513356686449749 -0.265953575867554 Nonsignificant None -- -- palladin -- -- -- -- -- IPR013098 [Immunoglobulin I-set] -- -- B2RUC7 Serine/threonine kinase receptor associated protein Strap 6271.5 6589.1 5846.2 5096.7 5241.3 5676.3 1.168130982934 0.0316225100650714 0.224202053185724 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) serine-threonine kinase receptor-associated protein -- ko03013 RNA transport Serine/threonine kinase receptor-associated protein I Lipid transport and metabolism ; IPR001680 [WD40 repeat] -- -- Q99PT1 Rho GDP-dissociation inhibitor 1 Arhgdia 9274.7 10131.8 9342.7 8941.2 9180.6 9137 1.05467592117041 0.155979796679651 0.0767997584145298 Nonsignificant None 2 Molecular Function:Rho GDP-dissociation inhibitor activity (GO:0005094),Cellular Component:cytoplasm (GO:0005737) Rho GDP-dissociation inhibitor -- ko04722 Neurotrophin signaling pathway ko04962 Vasopressin-regulated water reabsorption Rho GDP-dissociation inhibitor T Signal transduction mechanisms ; IPR000406 [Rho protein GDP-dissociation inhibitor] -- -- Q790Y8 Glucose-6-phosphate 1-dehydrogenase G6pdx 8697.3 9553.7 7822.8 7345.3 7924.3 7406.2 1.14985138341315 0.100480621941055 0.201447407023369 Nonsignificant None 4 Molecular Function:glucose-6-phosphate dehydrogenase activity (GO:0004345),Biological Process:glucose metabolic process (GO:0006006),Molecular Function:NADP binding (GO:0050661),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00030 Pentose phosphate pathway ko00480 Glutathione metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko05230 Central carbon metabolism in cancer Glucose-6-phosphate 1-dehydrogenase G Carbohydrate transport and metabolism ; IPR022674 [Glucose-6-phosphate dehydrogenase, NAD-binding] ; IPR022675[Glucose-6-phosphate dehydrogenase, C-terminal] -- -- Q9D6Z1 Nucleolar protein 56 Nop56 4894.7 4873.5 5024.4 4938.2 5042.8 4943.7 0.991148900815427 0.490961117443742 -0.0128262843665702 Nonsignificant None -- -- nucleolar protein 56 -- ko03008 Ribosome biogenesis in eukaryotes Ribosome biogenesis protein - Nop56p/Sik1p AJ RNA processing and modification ; Translation, ribosomal structure and biogenesis ; IPR002687 [Nop domain] ; IPR012974[NOP5, N-terminal] -- -- Q8BRF7 Sec1 family domain-containing protein 1 Scfd1 4056 3983 4060.9 4177.8 4260.2 4183.9 0.958643310436622 0.00891669087183919 -0.0609339741036152 Nonsignificant None 2 Biological Process:vesicle docking involved in exocytosis (GO:0006904),Biological Process:vesicle-mediated transport (GO:0016192) sec1 family domain-containing protein 1 -- -- Vesicle trafficking protein Sly1 (Sec1 family) U Intracellular trafficking, secretion, and vesicular transport ; IPR001619 [Sec1-like protein] -- -- Q61897 Keratin, type I cuticular Ha3-II Krt33b 1194.3 968.5 810 476.3 451.7 515.8 2.05901094334395 0.0107556491301426 1.04195149770504 Significant up 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) type I keratin, acidic -- -- -- -- -- IPR001664 [Intermediate filament protein] -- -- Q6P5F9 Exportin-1 Xpo1 5753.3 5590.1 5211.8 4330 4149.1 4968.2 1.23111702720992 0.0248193738475705 0.299967907679912 Nonsignificant None 2 Biological Process:intracellular protein transport (GO:0006886),Molecular Function:Ran GTPase binding (GO:0008536) exportin-1 -- ko03008 Ribosome biogenesis in eukaryotes ko03013 RNA transport ko05164 Influenza A ko05166 HTLV-I infection ko05169 Epstein-Barr virus infection Nuclear transport receptor CRM1/MSN5 (importin beta superfamily) YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; IPR001494 [Importin-beta, N-terminal domain] ; IPR013598[Exportin-1/Importin-beta-like] ; IPR014877[CRM1 C-terminal domain] -- -- Q3UKR1 Decorin Dcn 6853.8 7325.3 7611.2 9895.9 9618.2 10205.5 0.733196274512443 0.000687389371615356 -0.447728639555224 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) decorin -- ko04350 TGF-beta signaling pathway ko05205 Proteoglycans in cancer FOG: Leucine rich repeat R General function prediction only ; IPR000372 [Leucine-rich repeat N-terminal domain] ; IPR001611[Leucine-rich repeat] -- -- Q3UR33 Uncharacterized protein Tmpo 3930.6 3945.1 2836.8 2891.7 2968.7 2879 1.22577064787056 0.214447120492519 0.29368906374848 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) -- -- -- -- -- -- IPR003887 [LEM domain] ; IPR013146[LEM-like domain] -- -- Q9DCW4 Electron transfer flavoprotein subunit beta Etfb 6487.9 6348.3 6812.8 7414.9 7030.2 7423.5 0.898502876270086 0.0173518276985407 -0.154404972817201 Nonsignificant None -- -- electron transfer flavoprotein beta subunit -- -- Electron transfer flavoprotein, beta subunit C Energy production and conversion ; IPR014730 [Electron transfer flavoprotein, alpha/beta-subunit, N-terminal] -- -- O70570 Polymeric immunoglobulin receptor Pigr 4660.9 4659.5 5395.6 6228.8 6430.9 5956.2 0.790507039681133 0.00984502186709681 -0.339149784653067 Nonsignificant None -- -- polymeric immunoglobulin receptor -- ko04672 Intestinal immune network for IgA production -- -- -- IPR013106 [Immunoglobulin V-set domain] -- -- Q3UEM7 Fibrinogen C-terminal domain-containing protein Fgg 12434.6 13640.5 9431.2 5596.6 6061.8 5230.3 2.1023702238775 0.00822237073896241 1.07201674785409 Significant up 5 Molecular Function:receptor binding (GO:0005102),Cellular Component:fibrinogen complex (GO:0005577),Biological Process:signal transduction (GO:0007165),Biological Process:platelet activation (GO:0030168),Biological Process:protein polymerization (GO:0051258) fibrinogen gamma chain -- ko04610 Complement and coagulation cascades ko04611 Platelet activation ko05150 Staphylococcus aureus infection Ficolin and related extracellular proteins R General function prediction only ; IPR002181 [Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain] ; IPR012290[Fibrinogen, alpha/beta/gamma chain, coiled coil domain] -- -- Q5RKN9 F-actin-capping protein subunit alpha Capza1 2846.2 2843.2 3206.1 3354.3 3190.6 3068 0.925371115896347 0.177379518943261 -0.111896026893428 Nonsignificant None 2 Cellular Component:F-actin capping protein complex (GO:0008290),Biological Process:barbed-end actin filament capping (GO:0051016) capping protein (actin filament) muscle Z-line, alpha -- ko04144 Endocytosis F-actin capping protein, alpha subunit Z Cytoskeleton ; IPR002189 [F-actin-capping protein subunit alpha] -- -- Q5XJF6 Ribosomal protein Rpl10a 13644.3 13942.1 13546.5 11096.1 11426.2 11401.2 1.21251934499683 0.000112850199740835 0.278007764791195 Nonsignificant None -- -- large subunit ribosomal protein L10Ae -- ko03010 Ribosome 60S ribosomal protein L10A J Translation, ribosomal structure and biogenesis ; IPR028364 [Ribosomal protein L1/ribosomal biogenesis protein] -- -- E9QPI5 Sister chromatid cohesion protein PDS5 homolog A Pds5a 3089.8 3209.5 3330.6 3129.2 3096 3127.2 1.02967152816389 0.313937189583946 0.042184181809351 Nonsignificant None -- -- sister chromatid cohesion protein PDS5 -- -- Sister chromatid cohesion complex Cohesin, subunit PDS5 D Cell cycle control, cell division, chromosome partitioning ; -- -- -- A0A1L1STE6 Isocitrate dehydrogenase [NAD] subunit, mitochondrial Idh3a 5119.6 5359.5 5508 7297.3 7040.1 7017.9 0.748624463247999 0.00024356363098767 -0.41768590207305 Nonsignificant None 1 Biological Process:oxidation-reduction process (GO:0055114) isocitrate dehydrogenase (NAD+) 1.1.1.41 ko00020 Citrate cycle (TCA cycle) ko01100 Metabolic pathways ko01200 Carbon metabolism ko01210 2-Oxocarboxylic acid metabolism ko01230 Biosynthesis of amino acids Isocitrate dehydrogenase, alpha subunit E Amino acid transport and metabolism ; IPR024084 [Isopropylmalate dehydrogenase-like domain] -- -- Q99LC3 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial Ndufa10 4586.3 4565 5683.3 6753.4 6402 6690.1 0.74750447204656 0.0122436434187758 -0.41984588443268 Nonsignificant None -- -- NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 10 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease NADH:ubiquinone oxidoreductase, NDUFA10/42kDa subunit C Energy production and conversion ; IPR031314 [Deoxynucleoside kinase domain] -- -- Q5SW88 RAB1A, member RAS oncogene family Rab1a 4970.2 4805.8 5445.1 5388.2 5276.8 5278 0.954719939785486 0.28515583677891 -0.0668505038731799 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-1A -- ko05134 Legionellosis GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- Q9EPL8 Importin-7 Ipo7 3062.4 3161.8 2980.5 2358.5 2348.1 2640.7 1.25280034842731 0.00478019122172795 0.325156518982242 Nonsignificant None 2 Biological Process:intracellular protein transport (GO:0006886),Molecular Function:Ran GTPase binding (GO:0008536) importin-7 -- Nuclear transport receptor RANBP7/RANBP8 (importin beta superfamily) YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; IPR001494 [Importin-beta, N-terminal domain] ; IPR013713[Exportin/Importin, Cse1-like] -- -- Q5RKP0 Vat1 protein (Fragment) Vat1 4799.3 5168.8 5115.6 5498.9 5592.2 5567.5 0.905460242757495 0.0114728551040398 -0.143276798643803 Nonsignificant None 1 Biological Process:oxidation-reduction process (GO:0055114) -- -- -- Predicted quinone oxidoreductase CR Energy production and conversion ; General function prediction only ; IPR013154 [Alcohol dehydrogenase, N-terminal] -- -- Q60668 Heterogeneous nuclear ribonucleoprotein D0 Hnrnpd 889 839.4 895.4 942.9 966.6 901.7 0.933338076266363 0.0736756978896139 -0.0995283422060123 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) heterogeneous nuclear ribonucleoprotein A/B/D -- -- FOG: RRM domain R General function prediction only ; IPR000504 [RNA recognition motif domain] ; IPR012956[CARG-binding factor, N-terminal] -- -- Q5NC81 Nucleoside diphosphate kinase Nme1 1048 1038.2 1097.6 1053.9 1031 1050.2 1.01553379477529 0.456391456653904 0.0222382502135485 Nonsignificant None 5 Molecular Function:nucleoside diphosphate kinase activity (GO:0004550),Biological Process:nucleoside diphosphate phosphorylation (GO:0006165),Biological Process:GTP biosynthetic process (GO:0006183),Biological Process:UTP biosynthetic process (GO:0006228),Biological Process:CTP biosynthetic process (GO:0006241) nucleoside-diphosphate kinase 2.7.4.6 ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways Nucleoside diphosphate kinase F Nucleotide transport and metabolism ; IPR001564 [Nucleoside diphosphate kinase] -- -- Q9ERK4 Exportin-2 Cse1l 5772.5 5752 5952.5 5135.8 5124.1 5238.9 1.12763568792423 0.000849579551282516 0.173301042808622 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Biological Process:intracellular protein transport (GO:0006886),Molecular Function:Ran GTPase binding (GO:0008536) exportin-2 (importin alpha re-exporter) -- -- Nuclear export receptor CSE1/CAS (importin beta superfamily) YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; IPR001494 [Importin-beta, N-terminal domain] ; IPR005043[CAS/CSE, C-terminal] ; IPR013713[Exportin/Importin, Cse1-like] -- -- P11087 Collagen alpha-1(I) chain Col1a1 5263.7 5071.8 7147.2 7059.1 7443.8 7212.3 0.805090443560271 0.103539116893943 -0.312777230732862 Nonsignificant None 2 Molecular Function:extracellular matrix structural constituent (GO:0005201),Molecular Function:protein binding (GO:0005515) collagen, type I, alpha -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04611 Platelet activation ko04926 Relaxin signaling pathway ko04933 AGE-RAGE signaling pathway in diabetic complications ko04974 Protein digestion and absorption ko05146 Amoebiasis ko05165 Human papillomavirus infection Collagens (type IV and type XIII), and related proteins W Extracellular structures ; IPR000885 [Fibrillar collagen, C-terminal] ; IPR001007[VWFC domain] ; IPR008160[Collagen triple helix repeat] -- -- Q9CQ62 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial Decr1 4292 3954.7 4592.8 5362.3 4981.5 5552 0.807729085670429 0.0149995923921468 -0.308056604259223 Nonsignificant None -- -- 2,4-dienoyl-CoA reductase, mitochondrial 1.3.1.34 -- Reductases with broad range of substrate specificities R General function prediction only ; -- -- -- P00688 Pancreatic alpha-amylase Amy2 4000.3 3672.8 3271.5 3553.2 11339.5 3649.8 0.590244033976001 0.429818709133544 -0.760616540723552 Nonsignificant None 3 Molecular Function:catalytic activity (GO:0003824),Biological Process:carbohydrate metabolic process (GO:0005975),Molecular Function:cation binding (GO:0043169) alpha-amylase 3.2.1.1 ko00500 Starch and sucrose metabolism ko01100 Metabolic pathways ko04973 Carbohydrate digestion and absorption Alpha-amylase G Carbohydrate transport and metabolism ; IPR006047 [Glycosyl hydrolase, family 13, catalytic domain] ; IPR006048[Alpha-amylase/branching enzyme, C-terminal all beta] -- -- Q3TDF8 Eukaryotic peptide chain release factor subunit 1 Etf1 5020.3 5242.7 5232.7 4917.8 5072.2 4898.5 1.04078315478389 0.0901933892377838 0.0576695171429733 Nonsignificant None -- -- peptide chain release factor subunit 1 -- ko03015 mRNA surveillance pathway Peptide chain release factor 1 (eRF1) J Translation, ribosomal structure and biogenesis ; IPR005140 [eRF1 domain 1/Pelota-like] ; IPR005141[eRF1 domain 2] ; IPR005142[eRF1 domain 3] -- -- B9EIE9 Adenylosuccinate synthetase isozyme 2 Adss 4313.3 4330 3993.5 3665.5 3729.9 3568.8 1.15255102971489 0.00943322498123806 0.204830628040123 Nonsignificant None 3 Molecular Function:adenylosuccinate synthase activity (GO:0004019),Molecular Function:GTP binding (GO:0005525),Biological Process:purine nucleotide biosynthetic process (GO:0006164) adenylosuccinate synthase 6.3.4.4 ko00230 Purine metabolism ko00250 Alanine, aspartate and glutamate metabolism ko01100 Metabolic pathways Adenylosuccinate synthase F Nucleotide transport and metabolism ; IPR001114 [Adenylosuccinate synthetase] -- -- Q6RI64 Proteasome subunit beta Psmb1 3697.4 3855.3 3897.9 3972.7 3964.9 3846.1 0.971732138462452 0.205225470525899 -0.0413694104484062 Nonsignificant None 3 Molecular Function:threonine-type endopeptidase activity (GO:0004298),Cellular Component:proteasome core complex (GO:0005839),Biological Process:proteolysis involved in cellular protein catabolic process (GO:0051603) 20S proteasome subunit beta 6 3.4.25.1 ko03050 Proteasome 20S proteasome, regulatory subunit beta type PSMB1/PRE7 O Posttranslational modification, protein turnover, chaperones ; IPR001353 [Proteasome, subunit alpha/beta] -- -- Q9NYQ2 2-Hydroxyacid oxidase 2 Hao2 3269.2 3044 4470.8 6216.1 5570.7 6281.2 0.596856320566748 0.00816079923170801 -0.744544417255658 Significant down 1 Molecular Function:oxidoreductase activity (GO:0016491) (S)-2-hydroxy-acid oxidase 1.1.3.15 ko00630 Glyoxylate and dicarboxylate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko04146 Peroxisome Glycolate oxidase C Energy production and conversion ; IPR000262 [FMN-dependent dehydrogenase] -- -- E9Q5L2 Inter alpha-trypsin inhibitor, heavy chain 4 Itih4 7526.2 8377.5 7401.3 4488.6 4651 4429.6 1.71749255667246 0.00049318935582421 0.780303846656189 Significant up 2 Molecular Function:serine-type endopeptidase inhibitor activity (GO:0004867),Biological Process:hyaluronan metabolic process (GO:0030212) -- -- -- -- -- -- IPR002035 [von Willebrand factor, type A] ; IPR010600[Inter-alpha-trypsin inhibitor heavy chain, C-terminal] ; IPR013694[VIT domain] -- -- Q3TV47 Sodium/potassium-transporting ATPase subunit beta Atp1b1 8525.3 7864.2 10176.6 12180.3 11769.4 12737.2 0.724130411672831 0.0104743727023886 -0.465678553199315 Nonsignificant None 3 Cellular Component:sodium:potassium-exchanging ATPase complex (GO:0005890),Biological Process:potassium ion transport (GO:0006813),Biological Process:sodium ion transport (GO:0006814) sodium/potassium-transporting ATPase subunit beta -- ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04260 Cardiac muscle contraction ko04261 Adrenergic signaling in cardiomyocytes ko04911 Insulin secretion ko04918 Thyroid hormone synthesis ko04919 Thyroid hormone signaling pathway ko04925 Aldosterone synthesis and secretion ko04960 Aldosterone-regulated sodium reabsorption ko04961 Endocrine and other factor-regulated calcium reabsorption ko04964 Proximal tubule bicarbonate reclamation ko04970 Salivary secretion ko04971 Gastric acid secretion ko04972 Pancreatic secretion ko04973 Carbohydrate digestion and absorption ko04974 Protein digestion and absorption ko04976 Bile secretion ko04978 Mineral absorption Na+/K+ ATPase, beta subunit P Inorganic ion transport and metabolism ; IPR000402 [Sodium/potassium-transporting ATPase subunit beta] -- -- P19157 Glutathione S-transferase P 1 Gstp1 5456.7 5146 5880.3 6694.2 6800.2 7362.5 0.790290023924936 0.008005140085696 -0.339545898188997 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) glutathione S-transferase 2.5.1.18 ko00480 Glutathione metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko01524 Platinum drug resistance ko05200 Pathways in cancer ko05204 Chemical carcinogenesis ko05225 Hepatocellular carcinoma ko05418 Fluid shear stress and atherosclerosis Glutathione S-transferase O Posttranslational modification, protein turnover, chaperones ; IPR004045 [Glutathione S-transferase, N-terminal] ; IPR004046[Glutathione S-transferase, C-terminal] -- -- Q80W39 Splicing factor 3b, subunit 2 Sf3b2 5663.5 5690.9 5696.7 5092.9 5284.9 5064.2 1.10420282346846 0.0147163574751195 0.143005195246965 Nonsignificant None 1 Cellular Component:nucleus (GO:0005634) splicing factor 3B subunit 2 -- ko03040 Spliceosome Splicing factor 3b, subunit 2 A RNA processing and modification ; IPR006568 [PSP, proline-rich] ; IPR007180[Domain of unknown function DUF382] -- -- O55111 Desmoglein-2 Dsg2 5525.7 5327.5 4958.8 5234.1 5470.4 5179.3 0.995479671111447 0.905137040646819 -0.00653624020342347 Nonsignificant None 3 Molecular Function:calcium ion binding (GO:0005509),Biological Process:homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156),Cellular Component:membrane (GO:0016020) desmoglein 2 -- ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) FOG: Cadherin repeats S Function unknown ; IPR002126 [Cadherin] -- -- Q4FZE6 40S ribosomal protein S7 Rps7 8360.5 8325.5 8333.8 6744.9 6816.2 7003.2 1.21666188491706 0.00229734425870423 0.282928293172874 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S7e -- ko03010 Ribosome 40S ribosomal protein S7 J Translation, ribosomal structure and biogenesis ; IPR000554 [Ribosomal protein S7e] -- -- Q3U9N8 Inosine-5-monophosphate dehydrogenase Impdh2 7184.9 7632.3 6293.2 4756.2 4886.2 5107.2 1.43125237294571 0.00645735619985083 0.51727808512865 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:oxidation-reduction process (GO:0055114) IMP dehydrogenase 1.1.1.205 ko00230 Purine metabolism ko00983 Drug metabolism - other enzymes ko01100 Metabolic pathways IMP dehydrogenase/GMP reductase F Nucleotide transport and metabolism ; IPR000644 [CBS domain] ; IPR001093[IMP dehydrogenase/GMP reductase] -- -- Q3UHY8 Uncharacterized protein Abce1 6052.6 5986.2 5688.8 5466.9 5489.2 5669 1.06631539058412 0.046302521890611 0.0926342158964478 Nonsignificant None 2 Molecular Function:ATP binding (GO:0005524),Molecular Function:ATPase activity (GO:0016887) ATP-binding cassette, sub-family E, member 1 -- -- RNAse L inhibitor, ABC superfamily A RNA processing and modification ; IPR003439 [ABC transporter-like] ; IPR007209[RNase L inhibitor RLI, possible metal-binding domain] ; IPR017896[4Fe-4S ferredoxin-type, iron-sulphur binding domain] -- -- P63242 Eukaryotic translation initiation factor 5A-1 Eif5a 3069.4 3340.9 2647.8 2378.6 2517.5 2436.6 1.23530213973025 0.0489590932758101 0.304863950456753 Nonsignificant None 6 Molecular Function:RNA binding (GO:0003723),Molecular Function:translation elongation factor activity (GO:0003746),Biological Process:translational frameshifting (GO:0006452),Molecular Function:ribosome binding (GO:0043022),Biological Process:positive regulation of translational elongation (GO:0045901),Biological Process:positive regulation of translational termination (GO:0045905) translation initiation factor 5A -- -- Translation initiation factor 5A (eIF-5A) J Translation, ribosomal structure and biogenesis ; IPR020189 [Translation elongation factor, IF5A C-terminal] -- -- Q01320 DNA topoisomerase 2-alpha Top2a 2494.2 2335.8 2026.3 1518.7 1558.7 1641.8 1.45285217833531 0.00742146864772683 0.538887922219581 Nonsignificant None 5 Molecular Function:DNA binding (GO:0003677),Molecular Function:DNA topoisomerase type II (ATP-hydrolyzing) activity (GO:0003918),Molecular Function:ATP binding (GO:0005524),Cellular Component:nucleus (GO:0005634),Biological Process:DNA topological change (GO:0006265) DNA topoisomerase II 5.99.1.3 ko01524 Platinum drug resistance DNA topoisomerase type II B Chromatin structure and dynamics ; IPR002205 [DNA topoisomerase, type IIA, subunit A/C-terminal] ; IPR003594[Histidine kinase-like ATPase, C-terminal domain] ; IPR006171[TOPRIM domain] ; IPR012542[DTHCT] ; IPR013506[DNA topoisomerase, type IIA, subunit B, domain 2] ; IPR031660[C-terminal associated domain of TOPRIM] -- -- Q4FE56 Ubiquitinyl hydrolase 1 Usp9x 4931 4937 5053.8 4752.4 4797.1 4928.3 1.03066764287392 0.0890877865465876 0.0435791850054065 Nonsignificant None 2 Biological Process:protein deubiquitination (GO:0016579),Molecular Function:thiol-dependent ubiquitinyl hydrolase activity (GO:0036459) ubiquitin carboxyl-terminal hydrolase 9/24 3.4.19.12 -- Ubiquitin carboxyl-terminal hydrolase O Posttranslational modification, protein turnover, chaperones ; IPR001394 [Peptidase C19, ubiquitin carboxyl-terminal hydrolase] -- -- P49290 Eosinophil peroxidase Epx 7066.5 9057 7311.2 3411.7 3409.6 3385.3 2.2960339388239 0.0195935879358617 1.19914396736685 Significant up -- -- eosinophil peroxidase 1.11.1.7 ko05310 Asthma Peroxidase/oxygenase R General function prediction only ; IPR019791 [Haem peroxidase, animal] -- -- Q68FL4 Putative adenosylhomocysteinase 3 Ahcyl2 1142.3 1019.9 1332.8 2018.4 1715.8 1895.7 0.620792554041812 0.00491429512950609 -0.687816841343273 Significant down 3 Molecular Function:adenosylhomocysteinase activity (GO:0004013),Biological Process:S-adenosylhomocysteine catabolic process (GO:0019510),Molecular Function:NAD binding (GO:0051287) adenosylhomocysteinase 3.3.1.1 ko00270 Cysteine and methionine metabolism ko01100 Metabolic pathways S-adenosylhomocysteine hydrolase H Coenzyme transport and metabolism ; IPR000043 [Adenosylhomocysteinase] ; IPR015878[S-adenosyl-L-homocysteine hydrolase, NAD binding domain] -- -- O70318 Band 4.1-like protein 2 Epb41l2 4341.5 4471.8 4564.5 4254.5 4529.2 4277.8 1.02421620793936 0.38882820753749 0.0345202946317105 Nonsignificant None 5 Molecular Function:actin binding (GO:0003779),Molecular Function:structural molecule activity (GO:0005198),Cellular Component:cytoskeleton (GO:0005856),Molecular Function:cytoskeletal protein binding (GO:0008092),Biological Process:cortical actin cytoskeleton organization (GO:0030866) erythrocyte membrane protein band 4.1 -- -- Erythrocyte membrane protein 4.1 and related proteins of the ERM family R General function prediction only ; IPR007477 [SAB domain] ; IPR008379[Band 4.1, C-terminal] ; IPR014847[FERM adjacent (FA)] ; IPR018979[FERM, N-terminal] ; IPR018980[FERM, C-terminal PH-like domain] ; IPR019748[FERM central domain] -- -- Q9CR68 Cytochrome b-c1 complex subunit Rieske, mitochondrial Uqcrfs1 4355.7 4268.9 5070.9 5792.2 5520.8 5998.7 0.791112369091424 0.0140765970789594 -0.3380454661601 Nonsignificant None 3 Molecular Function:ubiquinol-cytochrome-c reductase activity (GO:0008121),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) ubiquinol-cytochrome c reductase iron-sulfur subunit 1.10.2.2 ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04260 Cardiac muscle contraction ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Ubiquinol cytochrome c reductase, subunit RIP1 C Energy production and conversion ; IPR004192 [Ubiquinol cytochrome reductase, transmembrane domain] ; IPR015248[Ubiquinol-cytochrome c reductase 8kDa, N-terminal] ; IPR017941[Rieske [2Fe-2S] iron-sulphur domain] -- -- Q3TJD7 PDZ and LIM domain protein 7 Pdlim7 5429.7 5644.7 5590.1 6269.7 5996.3 5901 0.917295095502835 0.0173331012701246 -0.124542168775133 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:zinc ion binding (GO:0008270) -- -- -- Adaptor protein Enigma and related PDZ-LIM proteins TZ Signal transduction mechanisms ; Cytoskeleton ; IPR001478 [PDZ domain] ; IPR001781[Zinc finger, LIM-type] -- -- Q99KC8 von Willebrand factor A domain-containing protein 5A Vwa5a 6846 6801.3 8242.1 7945.9 8118 7965.1 0.910957592908569 0.269780226699628 -0.134544199942943 Nonsignificant None -- -- -- -- -- -- -- -- IPR002035 [von Willebrand factor, type A] ; IPR013694[VIT domain] -- -- D3Z1V4 Phosphatidylethanolamine-binding protein 1 Pebp1 4952.5 4837.8 5055.2 5484.5 5233.6 5755.7 0.901158202721898 0.0292809400287414 -0.15014769445677 Nonsignificant None -- -- -- -- -- Phosphatidylethanolamine binding protein R General function prediction only ; IPR008914 [Phosphatidylethanolamine-binding protein] -- -- P63087 Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Ppp1cc 589.1 593.8 768.5 726.2 739.1 716.7 0.894317140238313 0.322254340351528 -0.161141568272609 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) serine/threonine-protein phosphatase PP1 catalytic subunit 3.1.3.16 ko03015 mRNA surveillance pathway ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04114 Oocyte meiosis ko04218 Cellular senescence ko04261 Adrenergic signaling in cardiomyocytes ko04270 Vascular smooth muscle contraction ko04390 Hippo signaling pathway ko04510 Focal adhesion ko04611 Platelet activation ko04720 Long-term potentiation ko04728 Dopaminergic synapse ko04750 Inflammatory mediator regulation of TRP channels ko04810 Regulation of actin cytoskeleton ko04910 Insulin signaling pathway ko04921 Oxytocin signaling pathway ko04931 Insulin resistance ko05031 Amphetamine addiction ko05034 Alcoholism ko05168 Herpes simplex infection ko05205 Proteoglycans in cancer Serine/threonine specific protein phosphatase PP1, catalytic subunit TR Signal transduction mechanisms ; General function prediction only ; IPR004843 [Calcineurin-like phosphoesterase domain, ApaH type] ; IPR031675[Serine-threonine protein phosphatase, N-terminal] -- -- O35841 Apoptosis inhibitor 5 Api5 4959.4 4897 5123.1 4578.3 4682.1 4570.8 1.08302244201515 0.00743319697814071 0.115063138281897 Nonsignificant None -- -- -- -- -- Apoptosis inhibitor 5/fibroblast growth factor 2-interacting factor 2, and related proteins T Signal transduction mechanisms ; IPR008383 [Apoptosis inhibitory 5] -- -- E9Q1G8 Septin Septin7 4538.2 4716.9 4349.6 4571.6 4559 4523.1 0.996411229190622 0.892267736650324 -0.00518681457081901 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) septin 7 -- -- Septin family protein (P-loop GTPase) DZU Cell cycle control, cell division, chromosome partitioning ; Cytoskeleton ; Intracellular trafficking, secretion, and vesicular transport ; IPR030379 [Septin-type guanine nucleotide-binding (G) domain] -- -- A0A171EBL2 E3 ubiquitin-protein ligase RNF213 Rnf213 3287.9 3397.1 3247 2608.2 3116.6 3041.9 1.13292344896027 0.0777969564502435 0.180050382308924 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q64525 Histone H2B type 2-B Hist2h2bb 4650.9 4792 5555.5 5063.2 4903.9 5521.4 0.968357168221584 0.652691491008347 -0.0463888265386302 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) histone H2B -- ko05034 Alcoholism ko05203 Viral carcinogenesis ko05322 Systemic lupus erythematosus Histone H2B B Chromatin structure and dynamics ; IPR007125 [Histone H2A/H2B/H3] -- -- E9Q3Y4 Lipopolysaccharide-responsive and beige-like anchor protein Lrba 3812.2 3564.3 3683.9 4459.3 4684.5 4493.8 0.811022467296298 0.00101405501755078 -0.302186213727204 Nonsignificant None -- -- -- -- -- Kinase A-anchor protein Neurobeachin and related BEACH and WD40 repeat proteins U Intracellular trafficking, secretion, and vesicular transport ; IPR000409 [BEACH domain] ; IPR010508[Domain of unknown function DUF1088] ; IPR023362[PH-BEACH domain] ; IPR031570[Domain of unknown function DUF4704] -- -- Q8C2Q7 Heterogeneous nuclear ribonucleoprotein H Hnrnph1 1475.9 1532.6 1657.6 1602.6 1656 1585.3 0.963294039926506 0.362676753892234 -0.0539518552886276 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) heterogeneous nuclear ribonucleoprotein F/H -- -- Splicing factor hnRNP-F and related RNA-binding proteins A RNA processing and modification ; IPR000504 [RNA recognition motif domain] ; IPR012996[Zinc finger, CHHC-type] -- -- P97371 Proteasome activator complex subunit 1 Psme1 7672.2 7799 9024.3 9141 9800.2 9020.9 0.876025048190229 0.0796672870595763 -0.19095597348193 Nonsignificant None 1 Cellular Component:proteasome activator complex (GO:0008537) proteasome activator subunit 1 (PA28 alpha) -- ko03050 Proteasome ko04612 Antigen processing and presentation Proteasome activator subunit O Posttranslational modification, protein turnover, chaperones ; IPR003185 [Proteasome activator pa28, N-terminal domain] ; IPR003186[Proteasome activator pa28, C-terminal domain] -- -- Q540D7 Aldo-keto reductase family 1 member A1 Akr1a1 4334.2 4207.6 4924.1 5401.2 5615.6 5478.6 0.816342737975435 0.011690803867172 -0.292753106216121 Nonsignificant None -- -- alcohol dehydrogenase (NADP+) 1.1.1.2 ko00010 Glycolysis / Gluconeogenesis ko00040 Pentose and glucuronate interconversions ko00561 Glycerolipid metabolism ko01100 Metabolic pathways Aldo/keto reductase family proteins R General function prediction only ; IPR023210 [NADP-dependent oxidoreductase domain] -- -- P63330 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Ppp2ca 773.5 768.2 964.4 791.5 750.2 808.4 1.066380154036 0.479846761209212 0.0927218363832305 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) serine/threonine-protein phosphatase 2A catalytic subunit 3.1.3.16 ko03015 mRNA surveillance pathway ko04071 Sphingolipid signaling pathway ko04114 Oocyte meiosis ko04136 Autophagy - other ko04140 Autophagy - animal ko04151 PI3K-Akt signaling pathway ko04152 AMPK signaling pathway ko04261 Adrenergic signaling in cardiomyocytes ko04350 TGF-beta signaling pathway ko04390 Hippo signaling pathway ko04530 Tight junction ko04728 Dopaminergic synapse ko04730 Long-term depression ko05142 Chagas disease (American trypanosomiasis) ko05160 Hepatitis C ko05165 Human papillomavirus infection Serine/threonine protein phosphatase 2A, catalytic subunit T Signal transduction mechanisms ; IPR004843 [Calcineurin-like phosphoesterase domain, ApaH type] -- -- Q9QUI0 Transforming protein RhoA Rhoa 1734.3 1628.6 1890.6 1751.2 1798.3 1838.2 0.975091411919743 0.606514114392904 -0.036390621315943 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras homolog gene family, member A -- ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04062 Chemokine signaling pathway ko04071 Sphingolipid signaling pathway ko04072 Phospholipase D signaling pathway ko04144 Endocytosis ko04150 mTOR signaling pathway ko04270 Vascular smooth muscle contraction ko04310 Wnt signaling pathway ko04350 TGF-beta signaling pathway ko04360 Axon guidance ko04510 Focal adhesion ko04520 Adherens junction ko04530 Tight junction ko04611 Platelet activation ko04621 NOD-like receptor signaling pathway ko04660 T cell receptor signaling pathway ko04670 Leukocyte transendothelial migration ko04722 Neurotrophin signaling pathway ko04810 Regulation of actin cytoskeleton ko04921 Oxytocin signaling pathway ko04972 Pancreatic secretion ko05100 Bacterial invasion of epithelial cells ko05133 Pertussis ko05152 Tuberculosis ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05205 Proteoglycans in cancer ko05206 MicroRNAs in cancer ko05210 Colorectal cancer ko05418 Fluid shear stress and atherosclerosis Ras-related small GTPase, Rho type R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- P51885 Lumican Lum 5796.5 5770 5624.2 6744.1 6759.5 7254.2 0.828156162984517 0.00249698227838754 -0.272025256727575 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) lumican -- ko05205 Proteoglycans in cancer FOG: Leucine rich repeat R General function prediction only ; IPR000372 [Leucine-rich repeat N-terminal domain] ; IPR001611[Leucine-rich repeat] -- -- Q61667 Histone H4 (Fragment) 406.7 408.7 438.5 384.5 376.1 368.1 1.11092407194117 0.0210833226810032 0.151760216567474 Nonsignificant None -- -- histone H4 -- ko05034 Alcoholism ko05203 Viral carcinogenesis ko05322 Systemic lupus erythematosus Histone H4 B Chromatin structure and dynamics ; -- -- -- P55264 Adenosine kinase Adk 4776.3 4761.8 5936.1 6060 5639.9 5915.8 0.878432307543839 0.155162810595646 -0.186996979209843 Nonsignificant None -- -- adenosine kinase 2.7.1.20 ko00230 Purine metabolism ko01100 Metabolic pathways Possible pfkB family carbohydrate kinase G Carbohydrate transport and metabolism ; IPR011611 [Carbohydrate kinase PfkB] -- -- Q9Z1T1 AP-3 complex subunit beta-1 Ap3b1 3946.7 3884.5 3725.7 3669.2 4019.2 3910.1 0.996413329309825 0.915366927383359 -0.00518377382993137 Nonsignificant None 3 Biological Process:intracellular protein transport (GO:0006886),Biological Process:vesicle-mediated transport (GO:0016192),Cellular Component:membrane coat (GO:0030117) AP-3 complex subunit beta -- ko04142 Lysosome Vesicle coat complex AP-3, beta subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR002553 [Clathrin/coatomer adaptor, adaptin-like, N-terminal] ; IPR029390[AP-3 complex subunit beta, C-terminal domain] ; IPR029394[AP-3 complex subunit beta 1, serine-rich domain] -- -- Q9DCX2 ATP synthase subunit d, mitochondrial Atp5pd 8797.3 8722.8 7987.1 8467.5 8342.1 8717 0.999240008461761 0.982744885979895 -0.00109685287560053 Nonsignificant None -- -- F-type H+-transporting ATPase subunit d -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Mitochondrial F1F0-ATP synthase, subunit d/ATP7 C Energy production and conversion ; -- -- -- Q6ZQM8 UDP-glucuronosyltransferase 1A7 Ugt1a7 3393.5 3035.7 3385.8 4811.2 4459.7 5188.7 0.67878779495975 0.00303310565010561 -0.558967470356439 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) glucuronosyltransferase 2.4.1.17 ko00040 Pentose and glucuronate interconversions ko00053 Ascorbate and aldarate metabolism ko00140 Steroid hormone biosynthesis ko00830 Retinol metabolism ko00860 Porphyrin and chlorophyll metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko00983 Drug metabolism - other enzymes ko01100 Metabolic pathways ko05204 Chemical carcinogenesis UDP-glucuronosyl and UDP-glucosyl transferase GC Carbohydrate transport and metabolism ; Energy production and conversion ; IPR002213 [UDP-glucuronosyl/UDP-glucosyltransferase] -- -- P14602 Heat shock protein beta-1 Hspb1 7935.6 9062.8 4739 5047.9 4919.3 4367.5 1.51641820198539 0.133087670604525 0.600667678791108 Nonsignificant None -- -- heat shock protein beta-1 -- ko04010 MAPK signaling pathway ko04370 VEGF signaling pathway ko05146 Amoebiasis ko05169 Epstein-Barr virus infection Alpha crystallins O Posttranslational modification, protein turnover, chaperones ; IPR002068 [Alpha crystallin/Hsp20 domain] -- -- P63085 Mitogen-activated protein kinase 1 Mapk1 3693.8 3722.7 3792.4 3630.1 3591 3777.2 1.01914841384578 0.332918620346873 0.0273641597747678 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) mitogen-activated protein kinase 1/3 2.7.11.24 ko01521 EGFR tyrosine kinase inhibitor resistance ko01522 Endocrine resistance ko01524 Platinum drug resistance ko04010 MAPK signaling pathway ko04012 ErbB signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04062 Chemokine signaling pathway ko04066 HIF-1 signaling pathway ko04068 FoxO signaling pathway ko04071 Sphingolipid signaling pathway ko04072 Phospholipase D signaling pathway ko04114 Oocyte meiosis ko04140 Autophagy - animal ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04210 Apoptosis ko04218 Cellular senescence ko04261 Adrenergic signaling in cardiomyocytes ko04270 Vascular smooth muscle contraction ko04350 TGF-beta signaling pathway ko04360 Axon guidance ko04370 VEGF signaling pathway ko04371 Apelin signaling pathway ko04380 Osteoclast differentiation ko04510 Focal adhesion ko04520 Adherens junction ko04540 Gap junction ko04550 Signaling pathways regulating pluripotency of stem cells ko04611 Platelet activation ko04620 Toll-like receptor signaling pathway ko04621 NOD-like receptor signaling pathway ko04650 Natural killer cell mediated cytotoxicity ko04657 IL-17 signaling pathway ko04658 Th1 and Th2 cell differentiation ko04659 Th17 cell differentiation ko04660 T cell receptor signaling pathway ko04662 B cell receptor signaling pathway ko04664 Fc epsilon RI signaling pathway ko04666 Fc gamma R-mediated phagocytosis ko04668 TNF signaling pathway ko04713 Circadian entrainment ko04720 Long-term potentiation ko04722 Neurotrophin signaling pathway ko04723 Retrograde endocannabinoid signaling ko04724 Glutamatergic synapse ko04725 Cholinergic synapse ko04726 Serotonergic synapse ko04730 Long-term depression ko04810 Regulation of actin cytoskeleton ko04910 Insulin signaling pathway ko04912 GnRH signaling pathway ko04914 Progesterone-mediated oocyte maturation ko04915 Estrogen signaling pathway ko04916 Melanogenesis ko04917 Prolactin signaling pathway ko04919 Thyroid hormone signaling pathway ko04921 Oxytocin signaling pathway ko04926 Relaxin signaling pathway ko04930 Type II diabetes mellitus ko04933 AGE-RAGE signaling pathway in diabetic complications ko04960 Aldosterone-regulated sodium reabsorption ko05010 Alzheimer's disease ko05020 Prion diseases ko05034 Alcoholism ko05132 Salmonella infection ko05133 Pertussis ko05140 Leishmaniasis ko05142 Chagas disease (American trypanosomiasis) ko05145 Toxoplasmosis ko05152 Tuberculosis ko05160 Hepatitis C ko05161 Hepatitis B ko05164 Influenza A ko05165 Human papillomavirus infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05205 Proteoglycans in cancer ko05210 Colorectal cancer ko05211 Renal cell carcinoma ko05212 Pancreatic cancer ko05213 Endometrial cancer ko05214 Glioma ko05215 Prostate cancer ko05216 Thyroid cancer ko05218 Melanoma ko05219 Bladder cancer ko05220 Chronic myeloid leukemia ko05221 Acute myeloid leukemia ko05223 Non-small cell lung cancer ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer ko05230 Central carbon metabolism in cancer ko05231 Choline metabolism in cancer Mitogen-activated protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q8R1B4 Eukaryotic translation initiation factor 3 subunit C Eif3c 7105.5 7711.8 7641.2 7097.2 7067 7093 1.05651261690157 0.171251077783163 0.0793099960779988 Nonsignificant None 5 Molecular Function:translation initiation factor activity (GO:0003743),Molecular Function:protein binding (GO:0005515),Cellular Component:eukaryotic translation initiation factor 3 complex (GO:0005852),Biological Process:translational initiation (GO:0006413),Molecular Function:translation initiation factor binding (GO:0031369) translation initiation factor 3 subunit C -- ko03013 RNA transport Translation initiation factor 3, subunit c (eIF-3c) J Translation, ribosomal structure and biogenesis ; IPR000717 [Proteasome component (PCI) domain] ; IPR008905[Eukaryotic translation initiation factor 3 subunit C, N-terminal domain] -- -- Q9DCD8 Proteasome subunit alpha type Psma3 8348.4 8267 7179 6920.3 7211.8 7188.9 1.11600769194691 0.101037164077936 0.158346970800984 Nonsignificant None 5 Molecular Function:endopeptidase activity (GO:0004175),Molecular Function:threonine-type endopeptidase activity (GO:0004298),Cellular Component:proteasome core complex (GO:0005839),Biological Process:ubiquitin-dependent protein catabolic process (GO:0006511),Biological Process:proteolysis involved in cellular protein catabolic process (GO:0051603) 20S proteasome subunit alpha 7 3.4.25.1 ko03050 Proteasome 20S proteasome, regulatory subunit alpha type PSMA3/PRE10 O Posttranslational modification, protein turnover, chaperones ; IPR000426 [Proteasome alpha-subunit, N-terminal domain] ; IPR001353[Proteasome, subunit alpha/beta] -- -- P00493 Hypoxanthine-guanine phosphoribosyltransferase Hprt1 5846.8 5607.7 6203.4 5805.2 6142.9 6000 0.983831157615569 0.652056872976217 -0.0235173494158047 Nonsignificant None 1 Biological Process:nucleoside metabolic process (GO:0009116) hypoxanthine phosphoribosyltransferase 2.4.2.8 ko00230 Purine metabolism ko00983 Drug metabolism - other enzymes ko01100 Metabolic pathways Hypoxanthine-guanine phosphoribosyltransferase F Nucleotide transport and metabolism ; IPR000836 [Phosphoribosyltransferase domain] -- -- P62334 26S proteasome regulatory subunit 10B Psmc6 4838.3 4800.9 4742.5 4500.2 4728.1 4618.1 1.03865986826901 0.0669912695176992 0.0547232897579967 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) 26S proteasome regulatory subunit T4 -- ko03050 Proteasome ko05169 Epstein-Barr virus infection 26S proteasome regulatory complex, ATPase RPT4 O Posttranslational modification, protein turnover, chaperones ; IPR003959 [ATPase, AAA-type, core] -- -- Q99L61 Testin Tes 7160.6 6617 5886.6 6675.3 6924 6854.5 0.961395926429319 0.522969877497485 -0.0567974043017879 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) -- -- -- FOG: LIM domain TZR Signal transduction mechanisms ; Cytoskeleton ; General function prediction only ; IPR001781 [Zinc finger, LIM-type] ; IPR010442[PET domain] -- -- Q5DQJ3 F-actin-capping protein subunit alpha Capza2 2952.6 3087.4 3463.8 3372.6 3333.8 3280.2 0.951655217992109 0.358590923118861 -0.0714891110476018 Nonsignificant None 2 Cellular Component:F-actin capping protein complex (GO:0008290),Biological Process:barbed-end actin filament capping (GO:0051016) capping protein (actin filament) muscle Z-line, alpha -- ko04144 Endocytosis F-actin capping protein, alpha subunit Z Cytoskeleton ; IPR002189 [F-actin-capping protein subunit alpha] -- -- Q9R1P0 Proteasome subunit alpha type-4 Psma4 5797 5650.9 4292.5 3892.3 3975 4047.3 1.32110184143824 0.115625559331341 0.401741685717681 Nonsignificant None 5 Molecular Function:endopeptidase activity (GO:0004175),Molecular Function:threonine-type endopeptidase activity (GO:0004298),Cellular Component:proteasome core complex (GO:0005839),Biological Process:ubiquitin-dependent protein catabolic process (GO:0006511),Biological Process:proteolysis involved in cellular protein catabolic process (GO:0051603) 20S proteasome subunit alpha 3 3.4.25.1 ko03050 Proteasome 20S proteasome, regulatory subunit alpha type PSMA4/PRE9 O Posttranslational modification, protein turnover, chaperones ; IPR000426 [Proteasome alpha-subunit, N-terminal domain] ; IPR001353[Proteasome, subunit alpha/beta] -- -- Q61753 D-3-phosphoglycerate dehydrogenase Phgdh 4506.2 4391.3 4069.7 3338.1 3818.8 3422.6 1.22569119523607 0.0157440164289052 0.293595547365892 Nonsignificant None 3 Biological Process:metabolic process (GO:0008152),Molecular Function:NAD binding (GO:0051287),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00260 Glycine, serine and threonine metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids D-3-phosphoglycerate dehydrogenase, D-isomer-specific 2-hydroxy acid dehydrogenase superfamily E Amino acid transport and metabolism ; IPR006139 [D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain] ; IPR006140[D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain] -- -- Q7TMB8 Cytoplasmic FMR1-interacting protein 1 Cyfip1 682.8 613.8 642.6 594.7 586.4 619.7 1.07685473123056 0.108196433407811 0.106823642018795 Nonsignificant None -- -- cytoplasmic FMR1 interacting protein -- ko03013 RNA transport ko04810 Regulation of actin cytoskeleton p53 inducible protein PIR121 R General function prediction only ; IPR008081 [Cytoplasmic FMR1-interacting] ; IPR009828[Protein of unknown function DUF1394] -- -- Q8K411 Presequence protease, mitochondrial Pitrm1 5053.6 4854.4 5650 5203.4 5107.7 5396.2 0.99049486544473 0.854005932317233 -0.0137785984365337 Nonsignificant None 1 Biological Process:proteolysis (GO:0006508) presequence protease 3.4.24.- -- Metalloendoprotease HMP1 (insulinase superfamily) RO General function prediction only ; Posttranslational modification, protein turnover, chaperones ; IPR007863 [Peptidase M16, C-terminal] ; IPR011765[Peptidase M16, N-terminal] ; IPR013578[Peptidase M16C associated] -- -- P28665 Murinoglobulin-1 Mug1 3289.6 3359.3 2306 1924.1 2366.8 1992.9 1.42507718259652 0.0722047039432004 0.511040058178281 Nonsignificant None 3 Molecular Function:endopeptidase inhibitor activity (GO:0004866),Cellular Component:extracellular region (GO:0005576),Cellular Component:extracellular space (GO:0005615) -- -- -- Alpha-macroglobulin O Posttranslational modification, protein turnover, chaperones ; IPR001599 [Alpha-2-macroglobulin] ; IPR002890[Alpha-2-macroglobulin, N-terminal] ; IPR009048[Alpha-macroglobulin, receptor-binding] ; IPR011625[Alpha-2-macroglobulin, N-terminal 2] ; IPR011626[Alpha-macroglobulin complement component] ; IPR019565[Alpha-2-macroglobulin, thiol-ester bond-forming] -- -- Q3TXS9 40S ribosomal protein S2 Rps2 17387 17350.6 16209.6 13670.9 13855.6 13958.9 1.22807541930414 0.00134152348931537 0.296399163081823 Nonsignificant None 4 Molecular Function:RNA binding (GO:0003723),Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S2e -- ko03010 Ribosome 40S ribosomal protein S2/30S ribosomal protein S5 J Translation, ribosomal structure and biogenesis ; IPR005324 [Ribosomal protein S5, C-terminal] ; IPR013810[Ribosomal protein S5, N-terminal] -- -- A0A0R4IZY0 Thimet oligopeptidase Thop1 6845.7 6617.1 6582.6 6757.7 6688.1 6693.3 0.995347359117339 0.733482229718963 -0.00672800559050371 Nonsignificant None 2 Molecular Function:metalloendopeptidase activity (GO:0004222),Biological Process:proteolysis (GO:0006508) thimet oligopeptidase 3.4.24.15 ko04614 Renin-angiotensin system ko05143 African trypanosomiasis Metalloendopeptidase family - saccharolysin & thimet oligopeptidase O Posttranslational modification, protein turnover, chaperones ; IPR001567 [Peptidase M3A/M3B catalytic domain] -- -- Q8R1F1 Protein Niban 2 Niban2 4415.5 4373.7 4227.4 4768.9 4767 5000 0.895479468075592 0.00621264874288505 -0.159267741006785 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q9DBS5 Kinesin light chain 4 Klc4 4764.9 4389.6 4673.8 4437.1 4579.3 4346.8 1.03480453783525 0.304485407038912 0.0493582856699413 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) kinesin light chain -- ko05132 Salmonella infection Kinesin light chain Z Cytoskeleton ; IPR011990 [Tetratricopeptide-like helical domain] -- -- Q14AI7 COP9 signalosome complex subunit 4 Cops4 4293 4491.6 3933.4 3466.9 3576.1 3530.1 1.20286387152302 0.0126778599335092 0.266473381507244 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) COP9 signalosome complex subunit 4 -- -- COP9 signalosome, subunit CSN4 OT Posttranslational modification, protein turnover, chaperones ; Signal transduction mechanisms ; IPR000717 [Proteasome component (PCI) domain] -- -- Q9R0H0 Peroxisomal acyl-coenzyme A oxidase 1 Acox1 3137.8 2927.1 4018.3 2918.4 2900.8 3099.6 1.13055568013634 0.317561299058779 0.177032046913343 Nonsignificant None 5 Molecular Function:acyl-CoA dehydrogenase activity (GO:0003995),Molecular Function:acyl-CoA oxidase activity (GO:0003997),Cellular Component:peroxisome (GO:0005777),Biological Process:fatty acid beta-oxidation (GO:0006635),Biological Process:oxidation-reduction process (GO:0055114) acyl-CoA oxidase 1.3.3.6 ko00071 Fatty acid degradation ko00592 alpha-Linolenic acid metabolism ko01040 Biosynthesis of unsaturated fatty acids ko01100 Metabolic pathways ko01212 Fatty acid metabolism ko03320 PPAR signaling pathway ko04024 cAMP signaling pathway ko04146 Peroxisome Acyl-CoA oxidase I Lipid transport and metabolism ; IPR002655 [Acyl-CoA oxidase, C-terminal] ; IPR006091[Acyl-CoA oxidase/dehydrogenase, central domain] ; IPR029320[Acyl-coenzyme A oxidase, N-terminal] -- -- Q3UZG0 Uncharacterized protein Golm1 5440.9 5045.5 5668.4 5611.3 6066.6 6301.4 0.898522189406707 0.0892787341675699 -0.154373962713936 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- P62715 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Ppp2cb 384.7 432.7 454.7 424.8 407.6 426.7 1.01032483519975 0.850383524383037 0.0148192165280286 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) serine/threonine-protein phosphatase 2A catalytic subunit 3.1.3.16 ko03015 mRNA surveillance pathway ko04071 Sphingolipid signaling pathway ko04114 Oocyte meiosis ko04136 Autophagy - other ko04140 Autophagy - animal ko04151 PI3K-Akt signaling pathway ko04152 AMPK signaling pathway ko04261 Adrenergic signaling in cardiomyocytes ko04350 TGF-beta signaling pathway ko04390 Hippo signaling pathway ko04530 Tight junction ko04728 Dopaminergic synapse ko04730 Long-term depression ko05142 Chagas disease (American trypanosomiasis) ko05160 Hepatitis C ko05165 Human papillomavirus infection Serine/threonine protein phosphatase 2A, catalytic subunit T Signal transduction mechanisms ; IPR004843 [Calcineurin-like phosphoesterase domain, ApaH type] -- -- Q99LF8 Polyadenylate-binding protein Pabpc4 4838.2 4801.9 4053.4 3437 3767.1 3348.2 1.29767917894677 0.0215004784082462 0.375933754560569 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:RNA binding (GO:0003723) polyadenylate-binding protein -- ko03013 RNA transport ko03015 mRNA surveillance pathway ko03018 RNA degradation Polyadenylate-binding protein (RRM superfamily) AJ RNA processing and modification ; Translation, ribosomal structure and biogenesis ; IPR000504 [RNA recognition motif domain] ; IPR002004[Polyadenylate-binding protein/Hyperplastic disc protein] -- -- P38060 Hydroxymethylglutaryl-CoA lyase, mitochondrial Hmgcl 4023.7 3886.2 4913.7 4951.4 4752.8 5023.5 0.8707130101781 0.12853332149446 -0.199730814662083 Nonsignificant None 1 Molecular Function:catalytic activity (GO:0003824) hydroxymethylglutaryl-CoA lyase 4.1.3.4 ko00072 Synthesis and degradation of ketone bodies ko00280 Valine, leucine and isoleucine degradation ko00650 Butanoate metabolism ko01100 Metabolic pathways ko04146 Peroxisome Hydroxymethylglutaryl-CoA lyase CE Energy production and conversion ; Amino acid transport and metabolism ; IPR000891 [Pyruvate carboxyltransferase] -- -- Q6ZWX6 Eukaryotic translation initiation factor 2 subunit 1 Eif2s1 7740.4 7765.7 6737 6268.6 6369.8 6672.9 1.15181784758147 0.0532318206851797 0.203912582084832 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:RNA binding (GO:0003723),Molecular Function:translation initiation factor activity (GO:0003743) translation initiation factor 2 subunit 1 -- ko03013 RNA transport ko04140 Autophagy - animal ko04141 Protein processing in endoplasmic reticulum ko04210 Apoptosis ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05160 Hepatitis C ko05162 Measles ko05164 Influenza A ko05168 Herpes simplex infection Translation initiation factor 2, alpha subunit (eIF-2alpha) J Translation, ribosomal structure and biogenesis ; IPR003029 [S1 domain] ; IPR011488[Translation initiation factor 2, alpha subunit] -- -- Q3THJ6 Ribosomal_L16 domain-containing protein 12753.3 13103.4 12317.5 10857.8 11051.4 10517.7 1.17723865062649 0.00225309768588526 0.235406814152572 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L10e -- ko03010 Ribosome 60s ribosomal protein L10 J Translation, ribosomal structure and biogenesis ; IPR016180 [Ribosomal protein L10e/L16] -- -- Q99JW5 Epithelial cell adhesion molecule Epcam 5728.2 5276.9 5822 6695 6676.9 7099.1 0.821996971325289 0.00504208325442924 -0.282795016627649 Nonsignificant None -- -- epithelial cell adhesion molecule -- -- -- -- -- IPR000716 [Thyroglobulin type-1] -- -- O35129 Prohibitin-2 Phb2 5787.4 5870 6783.4 6673.7 6619.3 6657.2 0.92434161061042 0.255404128992021 -0.113501965267164 Nonsignificant None -- -- prohibitin 2 -- -- Prohibitin-like protein O Posttranslational modification, protein turnover, chaperones ; IPR001107 [Band 7 domain] -- -- A2AEX6 Four and a half LIM domains protein 1 Fhl1 7438 7754.4 8163.2 12314.2 11558.5 11762 0.65541733198259 0.000185975016255913 -0.609514270595776 Significant down 1 Molecular Function:zinc ion binding (GO:0008270) four and a half LIM domains protein 1 -- ko04630 Jak-STAT signaling pathway FOG: LIM domain TZR Signal transduction mechanisms ; Cytoskeleton ; General function prediction only ; IPR001781 [Zinc finger, LIM-type] -- -- A0A0R4J083 Long-chain specific acyl-CoA dehydrogenase, mitochondrial Acadl 4999.2 4990.6 5805 6122.1 6239 6120.4 0.854627600573546 0.0772176003817789 -0.226632184646263 Nonsignificant None 4 Molecular Function:acyl-CoA dehydrogenase activity (GO:0003995),Biological Process:metabolic process (GO:0008152),Molecular Function:flavin adenine dinucleotide binding (GO:0050660),Biological Process:oxidation-reduction process (GO:0055114) long-chain-acyl-CoA dehydrogenase 1.3.8.8 ko00071 Fatty acid degradation ko01100 Metabolic pathways ko01212 Fatty acid metabolism ko03320 PPAR signaling pathway Isovaleryl-CoA dehydrogenase EI Amino acid transport and metabolism ; Lipid transport and metabolism ; IPR006091 [Acyl-CoA oxidase/dehydrogenase, central domain] ; IPR009075[Acyl-CoA dehydrogenase/oxidase C-terminal] ; IPR013786[Acyl-CoA dehydrogenase/oxidase, N-terminal] -- -- Q91V41 Ras-related protein Rab-14 Rab14 4904.2 4765.8 4615.6 4798.6 4646.4 5092 0.982706197977574 0.617593502095907 -0.0251679398440564 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-14 -- ko04152 AMPK signaling pathway GTPase Rab14, small G protein superfamily U Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- G3X972 Sec24-related gene family, member C (S. cerevisiae) Sec24c 3969.1 3926.9 3738.8 3650.3 3681.9 3703 1.05433521821082 0.0508722145279468 0.0763336343004166 Nonsignificant None 4 Biological Process:intracellular protein transport (GO:0006886),Biological Process:ER to Golgi vesicle-mediated transport (GO:0006888),Molecular Function:zinc ion binding (GO:0008270),Cellular Component:COPII vesicle coat (GO:0030127) protein transport protein SEC24 -- ko04141 Protein processing in endoplasmic reticulum Vesicle coat complex COPII, subunit SFB3 U Intracellular trafficking, secretion, and vesicular transport ; IPR006895 [Zinc finger, Sec23/Sec24-type] ; IPR006896[Sec23/Sec24, trunk domain] ; IPR006900[Sec23/Sec24, helical domain] ; IPR007123[Gelsolin-like domain] ; IPR012990[Sec23/Sec24 beta-sandwich] -- -- O70423 Membrane primary amine oxidase Aoc3 4307.1 4703.8 4425.2 5306.4 4741.2 5187.5 0.881917414391766 0.0451239445386666 -0.181284531424153 Nonsignificant None 5 Molecular Function:copper ion binding (GO:0005507),Molecular Function:primary amine oxidase activity (GO:0008131),Biological Process:amine metabolic process (GO:0009308),Molecular Function:quinone binding (GO:0048038),Biological Process:oxidation-reduction process (GO:0055114) primary-amine oxidase 1.4.3.21 ko00260 Glycine, serine and threonine metabolism ko00350 Tyrosine metabolism ko00360 Phenylalanine metabolism ko00410 beta-Alanine metabolism ko01100 Metabolic pathways Copper amine oxidase Q Secondary metabolites biosynthesis, transport and catabolism ; IPR015798 [Copper amine oxidase, C-terminal] ; IPR015800[Copper amine oxidase, N2-terminal] ; IPR015802[Copper amine oxidase, N3-terminal] -- -- P14152 Malate dehydrogenase, cytoplasmic Mdh1 11629.6 11077.2 12494.7 13846.4 13129.7 14182.7 0.855260600406232 0.0183643138000259 -0.22556401450427 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) malate dehydrogenase 1.1.1.37 ko00020 Citrate cycle (TCA cycle) ko00270 Cysteine and methionine metabolism ko00620 Pyruvate metabolism ko00630 Glyoxylate and dicarboxylate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko04964 Proximal tubule bicarbonate reclamation Malate dehydrogenase C Energy production and conversion ; IPR001236 [Lactate/malate dehydrogenase, N-terminal] ; IPR022383[Lactate/malate dehydrogenase, C-terminal] -- -- Q91WA0 Lactoperoxidase Lpo 3045.4 2788.8 2945.6 5471.6 4926.9 5471.8 0.553222056293832 0.000273139134961514 -0.85406941874711 Significant down -- -- lactoperoxidase 1.11.1.7 ko04970 Salivary secretion Peroxidase/oxygenase R General function prediction only ; IPR019791 [Haem peroxidase, animal] -- -- Q80T06 Elongation factor 1-delta Eef1d 93 97.7 101.7 80.4 91.1 114.1 1.02380952380952 0.835892640908207 0.0339473319233375 Nonsignificant None 2 Molecular Function:translation elongation factor activity (GO:0003746),Biological Process:translational elongation (GO:0006414) elongation factor 1-delta -- ko05168 Herpes simplex infection Elongation factor 1 beta/delta chain K Transcription ; IPR014038 [Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain] ; IPR018940[Elongation factor 1 beta central acidic region, eukaryote] -- -- P14685 26S proteasome non-ATPase regulatory subunit 3 Psmd3 6314.5 6433.3 6095.1 5944 5866.2 5924.1 1.06251163000513 0.0221393925482776 0.0874786327410699 Nonsignificant None 4 Cellular Component:proteasome complex (GO:0000502),Molecular Function:protein binding (GO:0005515),Molecular Function:enzyme regulator activity (GO:0030234),Biological Process:regulation of protein catabolic process (GO:0042176) 26S proteasome regulatory subunit N3 -- ko03050 Proteasome ko05169 Epstein-Barr virus infection 26S proteasome regulatory complex, subunit RPN3/PSMD3 O Posttranslational modification, protein turnover, chaperones ; IPR000717 [Proteasome component (PCI) domain] ; IPR013586[26S proteasome regulatory subunit, C-terminal] -- -- Q9CQM9 Glutaredoxin-3 Glrx3 3827.9 3710.9 3938.9 3901.8 4013.5 3815.8 0.978399297593576 0.387700295021653 -0.0315047267524678 Nonsignificant None 3 Molecular Function:electron carrier activity (GO:0009055),Molecular Function:protein disulfide oxidoreductase activity (GO:0015035),Biological Process:cell redox homeostasis (GO:0045454) -- -- -- Glutaredoxin-related protein O Posttranslational modification, protein turnover, chaperones ; IPR002109 [Glutaredoxin] ; IPR013766[Thioredoxin domain] -- -- P14873 Microtubule-associated protein 1B Map1b 5154.5 5056.4 4895 4650 5058.2 4935.7 1.03154897260976 0.341078767057635 0.0448123145487782 Nonsignificant None -- -- microtubule-associated protein 1 -- -- Microtubule-associated proteins Z Cytoskeleton ; IPR000102 [Neuraxin/MAP1B repeat] -- -- Q3UID0 SWI/SNF complex subunit SMARCC2 Smarcc2 3175.7 2998.6 3580.6 3513.7 3445.1 3563.3 0.927086798262704 0.219060351343924 -0.109223677761505 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) SWI/SNF related-matrix-associated actin-dependent regulator of chromatin subfamily C -- ko05225 Hepatocellular carcinoma Chromatin remodeling factor subunit and related transcription factors B Chromatin structure and dynamics ; IPR001005 [SANT/Myb domain] ; IPR007526[SWIRM domain] ; IPR032448[SMARCC, SWIRM-associated domain] ; IPR032450[SMARCC, N-terminal] ; IPR032451[SMARCC, C-terminal] -- MYB Q8BJ64 Choline dehydrogenase, mitochondrial Chdh 3675.6 3408.5 4178.5 5231.5 5028.1 5287.9 0.724399421128799 0.00394678016426547 -0.465142701463645 Nonsignificant None 2 Molecular Function:flavin adenine dinucleotide binding (GO:0050660),Biological Process:oxidation-reduction process (GO:0055114) choline dehydrogenase 1.1.99.1 ko00260 Glycine, serine and threonine metabolism ko01100 Metabolic pathways Glucose dehydrogenase/choline dehydrogenase/mandelonitrile lyase (GMC oxidoreductase family) R General function prediction only ; IPR000172 [Glucose-methanol-choline oxidoreductase, N-terminal] ; IPR007867[Glucose-methanol-choline oxidoreductase, C-terminal] -- -- Q99MN9 Propionyl-CoA carboxylase beta chain, mitochondrial Pccb 2853 2783 2890.4 3841.8 3614 3811.9 0.756711662539826 0.000305134081791789 -0.40218441457983 Nonsignificant None -- -- propionyl-CoA carboxylase beta chain 6.4.1.3 ko00280 Valine, leucine and isoleucine degradation ko00630 Glyoxylate and dicarboxylate metabolism ko00640 Propanoate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism 3-Methylcrotonyl-CoA carboxylase, non-biotin containing subunit/Acetyl-CoA carboxylase carboxyl transferase, subunit beta EI Amino acid transport and metabolism ; Lipid transport and metabolism ; IPR000022 [Carboxyl transferase] -- -- Q8BFY9 Transportin-1 Tnpo1 3419.1 3594.5 3362.7 2998.8 2855.9 3168.2 1.14999612098106 0.0167623580599114 0.201628994864583 Nonsignificant None 2 Biological Process:intracellular protein transport (GO:0006886),Molecular Function:Ran GTPase binding (GO:0008536) transportin-1 -- -- Nuclear transport receptor Karyopherin-beta2/Transportin (importin beta superfamily) YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; IPR001494 [Importin-beta, N-terminal domain] -- -- Q9CW03 Structural maintenance of chromosomes protein 3 Smc3 4914.1 4759.7 5237.1 4797.8 4789.8 4883.9 1.03036312752652 0.366127911872204 0.0431528713461696 Nonsignificant None 4 Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Cellular Component:chromosome (GO:0005694),Biological Process:chromosome organization (GO:0051276) structural maintenance of chromosome 3 (chondroitin sulfate proteoglycan 6) -- ko04110 Cell cycle ko04114 Oocyte meiosis Structural maintenance of chromosome protein 3 (sister chromatid cohesion complex Cohesin, subunit SMC3) D Cell cycle control, cell division, chromosome partitioning ; IPR003395 [RecF/RecN/SMC, N-terminal] ; IPR010935[SMCs flexible hinge] -- -- P17918 Proliferating cell nuclear antigen Pcna 7607.3 7734.8 6729 5821.7 5812.3 5853.2 1.26212887140308 0.0400638665216883 0.335859226201524 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Biological Process:regulation of DNA replication (GO:0006275) proliferating cell nuclear antigen -- ko03030 DNA replication ko03410 Base excision repair ko03420 Nucleotide excision repair ko03430 Mismatch repair ko04110 Cell cycle ko04530 Tight junction ko05161 Hepatitis B ko05166 HTLV-I infection DNA polymerase delta processivity factor (proliferating cell nuclear antigen) L Replication, recombination and repair ; IPR022648 [Proliferating cell nuclear antigen, PCNA, N-terminal] ; IPR022649[Proliferating cell nuclear antigen, PCNA, C-terminal] -- -- O89054 Cytoskeletal beta-actin (Fragment) Actb 228.7 207.5 234.6 256.2 266.6 251.9 0.865883567832709 0.0205004637175766 -0.207755050770706 Nonsignificant None -- -- actin beta/gamma 1 -- ko04015 Rap1 signaling pathway ko04145 Phagosome ko04210 Apoptosis ko04390 Hippo signaling pathway ko04510 Focal adhesion ko04520 Adherens junction ko04530 Tight junction ko04611 Platelet activation ko04670 Leukocyte transendothelial migration ko04810 Regulation of actin cytoskeleton ko04919 Thyroid hormone signaling pathway ko04921 Oxytocin signaling pathway ko05100 Bacterial invasion of epithelial cells ko05132 Salmonella infection ko05164 Influenza A ko05205 Proteoglycans in cancer ko05225 Hepatocellular carcinoma ko05410 Hypertrophic cardiomyopathy (HCM) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05414 Dilated cardiomyopathy (DCM) ko05416 Viral myocarditis ko05418 Fluid shear stress and atherosclerosis Actin and related proteins Z Cytoskeleton ; IPR004000 [Actin family] -- -- Q6P542 ATP-binding cassette sub-family F member 1 Abcf1 3910.3 3730.1 3509.4 3199.7 3360.1 3331 1.12729000687508 0.0290787792994004 0.172858711302625 Nonsignificant None 2 Molecular Function:ATP binding (GO:0005524),Molecular Function:ATPase activity (GO:0016887) ATP-binding cassette, subfamily F, member 1 -- -- eIF2-interacting protein ABC50 (ABC superfamily) J Translation, ribosomal structure and biogenesis ; IPR003439 [ABC transporter-like] ; IPR032781[ABC-transporter extension domain] -- -- Q9WV27 Sodium/potassium-transporting ATPase subunit alpha-4 Atp1a4 195.8 205.5 227.5 193.4 198.2 213.1 1.03985447329254 0.509145896705322 0.0563816386070543 Nonsignificant None 2 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:metal ion binding (GO:0046872) sodium/potassium-transporting ATPase subunit alpha 3.6.3.9 ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04260 Cardiac muscle contraction ko04261 Adrenergic signaling in cardiomyocytes ko04911 Insulin secretion ko04918 Thyroid hormone synthesis ko04919 Thyroid hormone signaling pathway ko04925 Aldosterone synthesis and secretion ko04960 Aldosterone-regulated sodium reabsorption ko04961 Endocrine and other factor-regulated calcium reabsorption ko04964 Proximal tubule bicarbonate reclamation ko04970 Salivary secretion ko04971 Gastric acid secretion ko04972 Pancreatic secretion ko04973 Carbohydrate digestion and absorption ko04974 Protein digestion and absorption ko04976 Bile secretion ko04978 Mineral absorption Na+/K+ ATPase, alpha subunit P Inorganic ion transport and metabolism ; IPR004014 [Cation-transporting P-type ATPase, N-terminal] ; IPR006068[Cation-transporting P-type ATPase, C-terminal] ; IPR008250[P-type ATPase, A domain] -- -- Q3TT81 Poly(rC)-binding protein 2 Pcbp2 2729.3 2784.3 2987.7 2602.1 2648.5 2537.2 1.09161765838876 0.0488393666606341 0.126467637452654 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) poly(rC)-binding protein 2 -- ko04216 Ferroptosis PolyC-binding proteins alphaCP-1 and related KH domain proteins AR RNA processing and modification ; General function prediction only ; IPR004088 [K Homology domain, type 1] -- -- Q9WV55 Vesicle-associated membrane protein-associated protein A Vapa 8097.9 7950.6 7179 7456.8 7318 7765.8 1.03047390042856 0.506509738530126 0.0433079651400284 Nonsignificant None -- -- vesicle-associated membrane protein-associated protein A -- ko04979 Cholesterol metabolism VAMP-associated protein involved in inositol metabolism U Intracellular trafficking, secretion, and vesicular transport ; IPR000535 [Major sperm protein (MSP) domain] -- -- P99029 Peroxiredoxin-5, mitochondrial Prdx5 6380.4 6754.8 6731.7 6749.8 6238.8 7088.5 0.989530360460425 0.811497322731147 -0.0151841226183698 Nonsignificant None 1 Molecular Function:oxidoreductase activity (GO:0016491) peroxiredoxin 5, atypical 2-Cys peroxiredoxin 1.11.1.15 ko04146 Peroxisome Alkyl hydroperoxide reductase/peroxiredoxin O Posttranslational modification, protein turnover, chaperones ; IPR013740 [Redoxin] -- -- P97805 Protein FAM3D Fam3d 2978 2744.6 3547.3 5335.3 5640.8 5400.6 0.566041998693265 0.000756471113340402 -0.821018994023506 Significant down -- -- -- -- -- -- -- -- -- -- -- Q63844 Mitogen-activated protein kinase 3 Mapk3 2507.3 2397.5 2753 3036.8 3050.4 3095.2 0.833964976476738 0.00884689364486434 -0.261941297937222 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) mitogen-activated protein kinase 1/3 2.7.11.24 ko01521 EGFR tyrosine kinase inhibitor resistance ko01522 Endocrine resistance ko01524 Platinum drug resistance ko04010 MAPK signaling pathway ko04012 ErbB signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04062 Chemokine signaling pathway ko04066 HIF-1 signaling pathway ko04068 FoxO signaling pathway ko04071 Sphingolipid signaling pathway ko04072 Phospholipase D signaling pathway ko04114 Oocyte meiosis ko04140 Autophagy - animal ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04210 Apoptosis ko04218 Cellular senescence ko04261 Adrenergic signaling in cardiomyocytes ko04270 Vascular smooth muscle contraction ko04350 TGF-beta signaling pathway ko04360 Axon guidance ko04370 VEGF signaling pathway ko04371 Apelin signaling pathway ko04380 Osteoclast differentiation ko04510 Focal adhesion ko04520 Adherens junction ko04540 Gap junction ko04550 Signaling pathways regulating pluripotency of stem cells ko04611 Platelet activation ko04620 Toll-like receptor signaling pathway ko04621 NOD-like receptor signaling pathway ko04650 Natural killer cell mediated cytotoxicity ko04657 IL-17 signaling pathway ko04658 Th1 and Th2 cell differentiation ko04659 Th17 cell differentiation ko04660 T cell receptor signaling pathway ko04662 B cell receptor signaling pathway ko04664 Fc epsilon RI signaling pathway ko04666 Fc gamma R-mediated phagocytosis ko04668 TNF signaling pathway ko04713 Circadian entrainment ko04720 Long-term potentiation ko04722 Neurotrophin signaling pathway ko04723 Retrograde endocannabinoid signaling ko04724 Glutamatergic synapse ko04725 Cholinergic synapse ko04726 Serotonergic synapse ko04730 Long-term depression ko04810 Regulation of actin cytoskeleton ko04910 Insulin signaling pathway ko04912 GnRH signaling pathway ko04914 Progesterone-mediated oocyte maturation ko04915 Estrogen signaling pathway ko04916 Melanogenesis ko04917 Prolactin signaling pathway ko04919 Thyroid hormone signaling pathway ko04921 Oxytocin signaling pathway ko04926 Relaxin signaling pathway ko04930 Type II diabetes mellitus ko04933 AGE-RAGE signaling pathway in diabetic complications ko04960 Aldosterone-regulated sodium reabsorption ko05010 Alzheimer's disease ko05020 Prion diseases ko05034 Alcoholism ko05132 Salmonella infection ko05133 Pertussis ko05140 Leishmaniasis ko05142 Chagas disease (American trypanosomiasis) ko05145 Toxoplasmosis ko05152 Tuberculosis ko05160 Hepatitis C ko05161 Hepatitis B ko05164 Influenza A ko05165 Human papillomavirus infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05205 Proteoglycans in cancer ko05210 Colorectal cancer ko05211 Renal cell carcinoma ko05212 Pancreatic cancer ko05213 Endometrial cancer ko05214 Glioma ko05215 Prostate cancer ko05216 Thyroid cancer ko05218 Melanoma ko05219 Bladder cancer ko05220 Chronic myeloid leukemia ko05221 Acute myeloid leukemia ko05223 Non-small cell lung cancer ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer ko05230 Central carbon metabolism in cancer ko05231 Choline metabolism in cancer Mitogen-activated protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q8K1M3 Protein kinase, cAMP dependent regulatory, type II alpha Prkar2a 3875.3 3512.9 3910 4229.7 4129.6 4313.9 0.89150332986144 0.0291465066695775 -0.165687908404883 Nonsignificant None -- -- cAMP-dependent protein kinase regulator -- ko04910 Insulin signaling pathway cAMP-dependent protein kinase types I and II, regulatory subunit T Signal transduction mechanisms ; IPR000595 [Cyclic nucleotide-binding domain] ; IPR003117[cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain] -- -- A0A498WGD8 Thioredoxin-like protein 1 Txnl1 5318.6 5322 5372.3 5216 5372.9 5192.5 1.01466916750098 0.262547392613039 0.0210094139056034 Nonsignificant None 1 Biological Process:cell redox homeostasis (GO:0045454) -- -- -- Thioredoxin-like protein O Posttranslational modification, protein turnover, chaperones ; IPR010400 [PITH domain] ; IPR013766[Thioredoxin domain] -- -- P10605 Cathepsin B Ctsb 3390.9 3417.4 3744.1 3469.9 3511.3 3576.6 0.999488529807346 0.988535066192664 -0.000738084280653306 Nonsignificant None 4 Molecular Function:cysteine-type endopeptidase activity (GO:0004197),Biological Process:proteolysis (GO:0006508),Molecular Function:cysteine-type peptidase activity (GO:0008234),Biological Process:regulation of catalytic activity (GO:0050790) cathepsin B 3.4.22.1 ko04140 Autophagy - animal ko04142 Lysosome ko04210 Apoptosis ko04612 Antigen processing and presentation ko04621 NOD-like receptor signaling pathway ko04924 Renin secretion Cysteine proteinase Cathepsin L O Posttranslational modification, protein turnover, chaperones ; IPR000668 [Peptidase C1A, papain C-terminal] ; IPR012599[Peptidase C1A, propeptide] -- -- A0A0R3P9C8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial Ndufa9 5839 5798 5941.6 6312.8 6139.1 6823.6 0.911965967160385 0.0543317938229532 -0.132948108134483 Nonsignificant None -- -- NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 9 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease NADH:ubiquinone oxidoreductase, NDUFA9/39kDa subunit C Energy production and conversion ; IPR016040 [NAD(P)-binding domain] -- -- Q9R0P3 S-formylglutathione hydrolase Esd 4501 4704.8 4255.1 4435.1 4923.2 4744 0.954518057338165 0.329933893492137 -0.0671556044495531 Nonsignificant None -- -- S-formylglutathione hydrolase 3.1.2.12 ko01200 Carbon metabolism Esterase D R General function prediction only ; IPR000801 [Putative esterase] -- -- P46735 Unconventional myosin-Ib Myo1b 3310.7 3379.5 4099.6 3525.5 3741 3430 1.00872247931566 0.913379134596457 0.0125293134074677 Nonsignificant None 4 Molecular Function:motor activity (GO:0003774),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Cellular Component:myosin complex (GO:0016459) myosin I -- -- Myosin class I heavy chain Z Cytoskeleton ; IPR000048 [IQ motif, EF-hand binding site] ; IPR001609[Myosin head, motor domain] ; IPR010926[Class I myosin tail homology domain] -- -- G5E8G0 Heterogeneous nuclear ribonucleoprotein D0 Hnrnpd 218.9 202.8 203.6 230.4 185.1 223 0.979326546593579 0.783526239522688 -0.0301381026789521 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) heterogeneous nuclear ribonucleoprotein A/B/D -- -- FOG: RRM domain R General function prediction only ; IPR000504 [RNA recognition motif domain] ; IPR012956[CARG-binding factor, N-terminal] -- -- Q01149 Collagen alpha-2(I) chain Col1a2 6994 6872.5 9267.2 8995.9 9151.6 9247.5 0.844449717101661 0.208832960118691 -0.243916574818453 Nonsignificant None 1 Molecular Function:extracellular matrix structural constituent (GO:0005201) collagen, type I, alpha -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04611 Platelet activation ko04926 Relaxin signaling pathway ko04933 AGE-RAGE signaling pathway in diabetic complications ko04974 Protein digestion and absorption ko05146 Amoebiasis ko05165 Human papillomavirus infection Collagens (type IV and type XIII), and related proteins W Extracellular structures ; IPR000885 [Fibrillar collagen, C-terminal] ; IPR008160[Collagen triple helix repeat] -- -- Q9QYJ0 DnaJ homolog subfamily A member 2 Dnaja2 4858.3 5086.8 5833.3 5536.3 5955.6 5669.7 0.919401454409845 0.222267011563856 -0.121233146517928 Nonsignificant None 2 Molecular Function:heat shock protein binding (GO:0031072),Molecular Function:unfolded protein binding (GO:0051082) DnaJ homolog subfamily A member 2 -- ko04141 Protein processing in endoplasmic reticulum Molecular chaperone (DnaJ superfamily) O Posttranslational modification, protein turnover, chaperones ; IPR001305 [Heat shock protein DnaJ, cysteine-rich domain] ; IPR001623[DnaJ domain] ; IPR002939[Chaperone DnaJ, C-terminal] -- -- A8DUP7 Beta-globin Hbbt1 426.4 415.5 608 493.3 740.4 527.8 0.823105307976157 0.354743459230152 -0.280851074233445 Nonsignificant None 2 Molecular Function:oxygen binding (GO:0019825),Molecular Function:heme binding (GO:0020037) hemoglobin subunit beta -- ko05143 African trypanosomiasis ko05144 Malaria Globins and related hemoproteins C Energy production and conversion ; IPR000971 [Globin] -- -- Q9CWK8 Sorting nexin-2 Snx2 5172.2 5247.5 5530.5 5453.7 5738.3 5541.1 0.95321249499495 0.1311151268455 -0.0691302319564278 Nonsignificant None 2 Biological Process:intracellular protein transport (GO:0006886),Molecular Function:phosphatidylinositol binding (GO:0035091) sorting nexin-1/2 -- ko04144 Endocytosis Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins U Intracellular trafficking, secretion, and vesicular transport ; IPR001683 [Phox homologous domain] ; IPR005329[Sorting nexin, N-terminal] ; IPR015404[Sorting nexin Vps5-like, C-terminal] -- -- Q9CZU5 Phenylalanine--tRNA ligase beta subunit Farsb 6197.5 5895.3 6025.4 5877.3 5922.7 5926.2 1.02211415870294 0.215653819176084 0.031556338151169 Nonsignificant None 5 Molecular Function:magnesium ion binding (GO:0000287),Molecular Function:RNA binding (GO:0003723),Molecular Function:phenylalanine-tRNA ligase activity (GO:0004826),Molecular Function:ATP binding (GO:0005524),Biological Process:phenylalanyl-tRNA aminoacylation (GO:0006432) phenylalanyl-tRNA synthetase beta chain 6.1.1.20 ko00970 Aminoacyl-tRNA biosynthesis Phenylalanyl-tRNA synthetase beta subunit J Translation, ribosomal structure and biogenesis ; IPR005146 [B3/B4 tRNA-binding domain] ; IPR005147[tRNA synthetase, B5-domain] -- -- Q3U607 Uncharacterized protein Casp8 5467.9 5733.8 5388.2 4897.5 5183.4 4823.9 1.11305753851108 0.0206772558737419 0.154528173433679 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Biological Process:regulation of apoptotic process (GO:0042981) caspase 8 3.4.22.61 ko01524 Platinum drug resistance ko04115 p53 signaling pathway ko04210 Apoptosis ko04215 Apoptosis - multiple species ko04217 Necroptosis ko04620 Toll-like receptor signaling pathway ko04621 NOD-like receptor signaling pathway ko04622 RIG-I-like receptor signaling pathway ko04657 IL-17 signaling pathway ko04668 TNF signaling pathway ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05016 Huntington's disease ko05134 Legionellosis ko05142 Chagas disease (American trypanosomiasis) ko05145 Toxoplasmosis ko05152 Tuberculosis ko05161 Hepatitis B ko05165 Human papillomavirus infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05416 Viral myocarditis Caspase, apoptotic cysteine protease D Cell cycle control, cell division, chromosome partitioning ; IPR001875 [Death effector domain] -- -- P15626 Glutathione S-transferase Mu 2 Gstm2 2895.3 2779.8 2307.7 3119.9 2885 3337.3 0.854488236175633 0.111002094897534 -0.226867464575064 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) glutathione S-transferase 2.5.1.18 ko00480 Glutathione metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko01524 Platinum drug resistance ko05200 Pathways in cancer ko05204 Chemical carcinogenesis ko05225 Hepatocellular carcinoma ko05418 Fluid shear stress and atherosclerosis Glutathione S-transferase O Posttranslational modification, protein turnover, chaperones ; IPR004045 [Glutathione S-transferase, N-terminal] ; IPR004046[Glutathione S-transferase, C-terminal] -- -- Q3UXT6 Uncharacterized protein (Fragment) Rbm39 4736.9 4767.5 4860.9 4828.7 4846.3 4675 1.00106620209059 0.942082447555777 0.00153738503267764 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) RNA-binding protein 39 -- -- Transcriptional coactivator CAPER (RRM superfamily) K Transcription ; IPR000504 [RNA recognition motif domain] ; IPR029123[Splicing factor RBM39, linker] -- -- Q8BXY4 Uncharacterized protein Rab2a 6595 6639.4 5393.1 5841.4 5668.8 5985.4 1.06469626648986 0.418136347182947 0.0904419212244729 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-2A -- ko04152 AMPK signaling pathway GTPase Rab2, small G protein superfamily U Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- P61750 ADP-ribosylation factor 4 Arf4 2383.3 2383.7 2623.1 2833.5 2869.9 2629 0.886911334069416 0.0455895923281206 -0.173138211660024 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) ADP-ribosylation factor 4 -- -- GTP-binding ADP-ribosylation factor Arf1 U Intracellular trafficking, secretion, and vesicular transport ; IPR006689 [Small GTPase superfamily, ARF/SAR type] -- -- P48722 Heat shock 70 kDa protein 4L Hspa4l 2489.1 2492.5 2472 2925.5 3041.6 2812.6 0.848958392655786 0.0208370137909901 -0.236234245679236 Nonsignificant None -- -- heat shock protein 110kDa -- ko04141 Protein processing in endoplasmic reticulum Molecular chaperones HSP105/HSP110/SSE1, HSP70 superfamily O Posttranslational modification, protein turnover, chaperones ; IPR013126 [Heat shock protein 70 family] -- -- P49722 Proteasome subunit alpha type-2 Psma2 3359.1 2834.6 2881.6 2948.3 3037.5 3015.5 1.00822103473943 0.897169157155079 0.0118119590410392 Nonsignificant None 5 Molecular Function:endopeptidase activity (GO:0004175),Molecular Function:threonine-type endopeptidase activity (GO:0004298),Cellular Component:proteasome core complex (GO:0005839),Biological Process:ubiquitin-dependent protein catabolic process (GO:0006511),Biological Process:proteolysis involved in cellular protein catabolic process (GO:0051603) 20S proteasome subunit alpha 2 3.4.25.1 ko03050 Proteasome 20S proteasome, regulatory subunit alpha type PSMA2/PRE8 O Posttranslational modification, protein turnover, chaperones ; IPR000426 [Proteasome alpha-subunit, N-terminal domain] ; IPR001353[Proteasome, subunit alpha/beta] -- -- Q69ZF7 Metal transporter CNNM4 Cnnm4 5224.7 5210.8 5741.8 6698.9 6861.5 6345.4 0.812692783007968 0.0058413809850781 -0.299218012198625 Nonsignificant None -- -- metal transporter CNNM -- -- Predicted membrane protein, contains two CBS domains S Function unknown ; IPR000644 [CBS domain] ; IPR002550[Domain of unknown function DUF21] -- -- Q80XN0 D-beta-hydroxybutyrate dehydrogenase, mitochondrial Bdh1 7419.6 6906.1 9176 10049.6 9809.7 10337.4 0.778287031364354 0.0338516683765236 -0.361625777263328 Nonsignificant None -- -- 3-hydroxybutyrate dehydrogenase 1.1.1.30 ko00072 Synthesis and degradation of ketone bodies ko00650 Butanoate metabolism ko01100 Metabolic pathways Corticosteroid 11-beta-dehydrogenase and related short chain-type dehydrogenases QR Secondary metabolites biosynthesis, transport and catabolism ; General function prediction only ; IPR002347 [Short-chain dehydrogenase/reductase SDR] -- -- Q00898 Alpha-1-antitrypsin 1-5 Serpina1e 177.6 170.8 124.5 57.2 113.5 62.4 2.02874302874303 0.0310624326408237 1.02058613732894 Significant up -- -- alpha-1-antitrypsin -- ko04610 Complement and coagulation cascades Serpin V Defense mechanisms ; IPR023796 [Serpin domain] -- -- Q3TIU3 Alpha-2-HS-glycoprotein Ahsg 8596.1 10351.2 8153.3 4219.7 4484.9 4389.1 2.06974346441418 0.0189358717104065 1.04945196310971 Significant up 1 Molecular Function:cysteine-type endopeptidase inhibitor activity (GO:0004869) -- -- -- -- -- -- IPR000010 [Cystatin domain] -- -- P47791 Glutathione reductase, mitochondrial Gsr 5653.9 5458.1 5145.9 5420.9 5537 5579.2 0.98311674961148 0.581309151006479 -0.0245653415117888 Nonsignificant None 3 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:cell redox homeostasis (GO:0045454),Biological Process:oxidation-reduction process (GO:0055114) glutathione reductase (NADPH) 1.8.1.7 ko00480 Glutathione metabolism ko04918 Thyroid hormone synthesis Pyridine nucleotide-disulphide oxidoreductase Q Secondary metabolites biosynthesis, transport and catabolism ; IPR004099 [Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain] ; IPR023753[FAD/NAD(P)-binding domain] -- -- P47911 60S ribosomal protein L6 Rpl6 11378.2 11158.8 10223.3 8939.1 9102.1 9366.9 1.19527803824417 0.00895565928670014 0.257346248113031 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L6e -- ko03010 Ribosome 60s ribosomal protein L6 J Translation, ribosomal structure and biogenesis ; IPR000915 [60S ribosomal protein L6E] ; IPR005568[Ribosomal protein L6, N-terminal] -- -- Q3UJS2 Uncharacterized protein Fbl 6613.3 6748.5 6421.5 6037.2 6050.2 6094.4 1.08808258808259 0.00520487898840105 0.121788064763996 Nonsignificant None 4 Molecular Function:RNA binding (GO:0003723),Biological Process:rRNA processing (GO:0006364),Biological Process:tRNA processing (GO:0008033),Molecular Function:methyltransferase activity (GO:0008168) rRNA 2'-O-methyltransferase fibrillarin 2.1.1.- ko03008 Ribosome biogenesis in eukaryotes Fibrillarin and related nucleolar RNA-binding proteins A RNA processing and modification ; IPR000692 [Fibrillarin] -- -- A0A0R4J119 Cytoplasmic FMR1-interacting protein Cyfip1 7.5 13.5 7.7 12 11.8 14.2 0.755263157894737 0.216137768436342 -0.40494868165526 Nonsignificant None -- -- cytoplasmic FMR1 interacting protein -- ko03013 RNA transport ko04810 Regulation of actin cytoskeleton p53 inducible protein PIR121 R General function prediction only ; IPR008081 [Cytoplasmic FMR1-interacting] ; IPR009828[Protein of unknown function DUF1394] -- -- Q542F1 Chloride intracellular channel protein Clic1 6000.5 6442.7 5666.8 5504.2 5519 5728.9 1.08105849415894 0.127736522717517 0.112444586856012 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) chloride intracellular channel protein 1 -- -- Intracellular Cl- channel CLIC, contains GST domain P Inorganic ion transport and metabolism ; IPR004045 [Glutathione S-transferase, N-terminal] -- -- F6ZFU0 Elongation factor 1-delta (Fragment) Eef1d 149.2 140.3 153 145.7 134.7 129.8 1.07874207703559 0.148314668447547 0.10934996337787 Nonsignificant None 2 Molecular Function:translation elongation factor activity (GO:0003746),Biological Process:translational elongation (GO:0006414) elongation factor 1-delta -- ko05168 Herpes simplex infection Elongation factor 1 beta/delta chain K Transcription ; IPR014038 [Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain] ; IPR018940[Elongation factor 1 beta central acidic region, eukaryote] -- -- Q8R2Y2 Cell surface glycoprotein MUC18 Mcam 3724.2 3883 3614.4 3666.8 3600.6 3543.2 1.03801824135571 0.185382080664205 0.053831796761478 Nonsignificant None -- -- melanoma cell adhesion molecule -- -- -- -- -- IPR013098 [Immunoglobulin I-set] ; IPR013106[Immunoglobulin V-set domain] ; IPR013162[CD80-like, immunoglobulin C2-set] -- -- G5E829 Plasma membrane calcium-transporting ATPase 1 Atp2b1 2668.8 2672.2 3674.3 3463.6 3268.4 3428.4 0.8872977441833 0.324353041381826 -0.172509794219603 Nonsignificant None 3 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:calcium-transporting ATPase activity (GO:0005388),Molecular Function:metal ion binding (GO:0046872) Ca2+ transporting ATPase, plasma membrane 3.6.3.8 ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04261 Adrenergic signaling in cardiomyocytes ko04925 Aldosterone synthesis and secretion ko04970 Salivary secretion ko04972 Pancreatic secretion Calcium transporting ATPase P Inorganic ion transport and metabolism ; IPR004014 [Cation-transporting P-type ATPase, N-terminal] ; IPR006068[Cation-transporting P-type ATPase, C-terminal] ; IPR008250[P-type ATPase, A domain] ; IPR022141[Plasma membrane calcium transporting P-type ATPase, C-terminal] -- -- Q3TCL2 Aldo_ket_red domain-containing protein (Fragment) Akr1b3 6012 5823.6 6100.1 7218.3 6917.2 7835.3 0.816342600178419 0.00886992570925053 -0.292753349740171 Nonsignificant None -- -- aldehyde reductase 1.1.1.21 ko00040 Pentose and glucuronate interconversions ko00051 Fructose and mannose metabolism ko00052 Galactose metabolism ko00561 Glycerolipid metabolism ko00790 Folate biosynthesis ko01100 Metabolic pathways Aldo/keto reductase family proteins R General function prediction only ; IPR023210 [NADP-dependent oxidoreductase domain] -- -- Q9CWR5 Serine hydroxymethyltransferase Shmt1 3944.7 3863 4328.7 4507.1 4398.4 4611.9 0.89783538254398 0.0421219935929801 -0.155477142747417 Nonsignificant None 1 Molecular Function:transferase activity (GO:0016740) glycine hydroxymethyltransferase 2.1.2.1 ko00260 Glycine, serine and threonine metabolism ko00630 Glyoxylate and dicarboxylate metabolism ko00670 One carbon pool by folate ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids ko01523 Antifolate resistance Glycine/serine hydroxymethyltransferase E Amino acid transport and metabolism ; IPR001085 [Serine hydroxymethyltransferase] -- -- Q9D6G1 Uncharacterized protein Hnrnpab 6592.1 6255 5972.9 5194.8 5324.7 5500.2 1.17480352316211 0.00948246830569885 0.232419497333861 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) heterogeneous nuclear ribonucleoprotein A/B/D -- -- FOG: RRM domain R General function prediction only ; IPR000504 [RNA recognition motif domain] ; IPR012956[CARG-binding factor, N-terminal] -- -- Q9D279 Mitotic interactor and substrate of PLK1 Misp 5417.8 5009.8 4639.2 3478.1 3635.9 3351.9 1.43960863375343 0.00304945678962849 0.525676659664736 Nonsignificant None -- -- -- -- -- -- -- -- IPR029304 [A-kinase anchor protein 2, C-terminal domain] -- -- Q61024 Asparagine synthetase [glutamine-hydrolyzing] Asns 5398.3 5348.8 4977.7 4248.6 4439.1 4208.5 1.21933592841302 0.00331872893345942 0.286095644817588 Nonsignificant None 2 Molecular Function:asparagine synthase (glutamine-hydrolyzing) activity (GO:0004066),Biological Process:asparagine biosynthetic process (GO:0006529) asparagine synthase (glutamine-hydrolysing) 6.3.5.4 ko00250 Alanine, aspartate and glutamate metabolism ko01100 Metabolic pathways Asparagine synthase (glutamine-hydrolyzing) E Amino acid transport and metabolism ; IPR001962 [Asparagine synthase] ; IPR017932[Glutamine amidotransferase type 2 domain] -- -- P62835 Ras-related protein Rap-1A Rap1a 18.4 18.5 17.3 20.4 20.8 25.7 0.8101644245142 0.0724836704567879 -0.303713359287589 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rap-1A -- ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04024 cAMP signaling pathway ko04062 Chemokine signaling pathway ko04510 Focal adhesion ko04530 Tight junction ko04611 Platelet activation ko04670 Leukocyte transendothelial migration ko04720 Long-term potentiation ko04722 Neurotrophin signaling pathway ko04972 Pancreatic secretion ko05211 Renal cell carcinoma Ras-related GTPase R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- Q8BT60 Copine-3 Cpne3 3881.1 3785.2 3403.4 3399.1 3417.1 3589.2 1.06384185134642 0.233646495972551 0.0892836985493102 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Copine T Signal transduction mechanisms ; IPR000008 [C2 domain] ; IPR010734[Copine] -- -- Q3UFJ3 Pyruvate dehydrogenase E1 component subunit alpha Pdha1 7098.5 6812.2 7927.2 8472 8405.4 8381.3 0.864569435481636 0.0753214850669993 -0.209946260340449 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) pyruvate dehydrogenase E1 component alpha subunit 1.2.4.1 ko00010 Glycolysis / Gluconeogenesis ko00020 Citrate cycle (TCA cycle) ko00620 Pyruvate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko04066 HIF-1 signaling pathway ko04922 Glucagon signaling pathway ko05230 Central carbon metabolism in cancer Pyruvate dehydrogenase E1, alpha subunit C Energy production and conversion ; IPR001017 [Dehydrogenase, E1 component] -- -- E9PUA7 Tumor protein D52 Tpd52 7763.6 7758.2 5716.5 4907.9 5064.7 4881.6 1.42978416878728 0.0880432507509877 0.515797383282716 Nonsignificant None -- -- -- -- -- Coiled-coil protein TPD52 R General function prediction only ; IPR007327 [Tumour protein D52] -- -- Q9JK53 Prolargin Prelp 4313.8 4241.8 4617.2 7101.3 6787.3 7467.8 0.616808076267536 0.000278758331827002 -0.697106439370405 Significant down 1 Molecular Function:protein binding (GO:0005515) proline arginine-rich end leucine-rich repeat protein -- -- FOG: Leucine rich repeat R General function prediction only ; IPR001611 [Leucine-rich repeat] -- -- Q3U8C4 Uncharacterized protein Psap 5179 5250 5615.7 5694.3 6007.7 5926 0.910182663943726 0.0327416866095517 -0.135771987026217 Nonsignificant None 1 Biological Process:lipid metabolic process (GO:0006629) saposin -- ko04142 Lysosome Prosaposin IG Lipid transport and metabolism ; Carbohydrate transport and metabolism ; IPR003119 [Saposin A-type domain] ; IPR007856[Saposin-like type B, region 1] ; IPR008138[Saposin B type, region 2] -- -- P42208 Septin-2 Septin2 3508.9 3414.6 3489.6 3457.5 3582.7 3640.6 0.974936334356977 0.218640149584451 -0.0366200843393841 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) septin 2 -- ko05100 Bacterial invasion of epithelial cells Septin family protein (P-loop GTPase) DZU Cell cycle control, cell division, chromosome partitioning ; Cytoskeleton ; Intracellular trafficking, secretion, and vesicular transport ; IPR030379 [Septin-type guanine nucleotide-binding (G) domain] -- -- Q6NZD2 Sorting nexin-1 Snx1 4551.9 4345.9 4856.8 4803.5 5040.4 4640.7 0.949601645885976 0.266050412750236 -0.0746056593710253 Nonsignificant None 2 Biological Process:intracellular protein transport (GO:0006886),Molecular Function:phosphatidylinositol binding (GO:0035091) sorting nexin-1/2 -- ko04144 Endocytosis Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins U Intracellular trafficking, secretion, and vesicular transport ; IPR001683 [Phox homologous domain] ; IPR005329[Sorting nexin, N-terminal] ; IPR015404[Sorting nexin Vps5-like, C-terminal] -- -- D1FNM8 Calcium-transporting ATPase Atp2b4 2357.8 2332.9 2826.9 3392.2 3015.1 3065.8 0.793573381469635 0.0308412478670321 -0.33356446012251 Nonsignificant None 3 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:calcium-transporting ATPase activity (GO:0005388),Molecular Function:metal ion binding (GO:0046872) Ca2+ transporting ATPase, plasma membrane 3.6.3.8 ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04261 Adrenergic signaling in cardiomyocytes ko04925 Aldosterone synthesis and secretion ko04970 Salivary secretion ko04972 Pancreatic secretion Calcium transporting ATPase P Inorganic ion transport and metabolism ; IPR004014 [Cation-transporting P-type ATPase, N-terminal] ; IPR006068[Cation-transporting P-type ATPase, C-terminal] ; IPR008250[P-type ATPase, A domain] ; IPR022141[Plasma membrane calcium transporting P-type ATPase, C-terminal] -- -- Q3TPJ8 Cytoplasmic dynein 1 intermediate chain 2 Dync1i2 2448.9 2381.4 2463.7 2670.5 2727.3 2568.2 0.915641476274165 0.0134044103747101 -0.127145280028074 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Cellular Component:cytoplasmic dynein complex (GO:0005868),Biological Process:microtubule-based movement (GO:0007018) dynein intermediate chain, cytosolic -- ko04145 Phagosome ko04962 Vasopressin-regulated water reabsorption ko05132 Salmonella infection Cytoplasmic dynein intermediate chain Z Cytoskeleton ; IPR001680 [WD40 repeat] ; IPR025956[Cytoplasmic dynein 1 intermediate chain 1/2] -- -- P61922 4-aminobutyrate aminotransferase, mitochondrial Abat 2553.6 2180.7 2480.8 5060.7 4847.9 5719.9 0.461662987490802 0.000608131526619931 -1.11508802181115 Significant down 2 Molecular Function:transaminase activity (GO:0008483),Molecular Function:pyridoxal phosphate binding (GO:0030170) -- -- ko00250 Alanine, aspartate and glutamate metabolism ko00280 Valine, leucine and isoleucine degradation ko00410 beta-Alanine metabolism ko00640 Propanoate metabolism ko00650 Butanoate metabolism ko01100 Metabolic pathways ko04727 GABAergic synapse 4-aminobutyrate aminotransferase E Amino acid transport and metabolism ; IPR005814 [Aminotransferase class-III] -- -- J3QMG3 Voltage-dependent anion-selective channel protein 3 Vdac3 5769.4 5505.2 6221.5 6626 5785.8 6990.3 0.901763211198788 0.199174662454544 -0.149179440649002 Nonsignificant None 2 Cellular Component:mitochondrial outer membrane (GO:0005741),Biological Process:transmembrane transport (GO:0055085) voltage-dependent anion channel protein 3 -- ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04216 Ferroptosis ko04217 Necroptosis ko04218 Cellular senescence ko04621 NOD-like receptor signaling pathway ko04979 Cholesterol metabolism ko05012 Parkinson's disease ko05016 Huntington's disease ko05161 Hepatitis B ko05166 HTLV-I infection ko05203 Viral carcinogenesis Porin/voltage-dependent anion-selective channel protein P Inorganic ion transport and metabolism ; IPR027246 [Eukaryotic porin/Tom40] -- -- Q99N15 17beta-hydroxysteroid dehydrogenase type 10/short chain L-3-hydroxyacyl-CoA dehydrogenase Hsd17b10 3416.5 3297.1 3424.8 3881.9 3812 3991.5 0.86761257637736 0.00149567491518323 -0.204877129307158 Nonsignificant None -- -- -- -- ko00280 Valine, leucine and isoleucine degradation ko01100 Metabolic pathways ko05010 Alzheimer's disease Short-chain alcohol dehydrogenase/3-hydroxyacyl-CoA dehydrogenase Q Secondary metabolites biosynthesis, transport and catabolism ; IPR002347 [Short-chain dehydrogenase/reductase SDR] -- -- Q9D066 Inositol-1-monophosphatase Impa1 5566.4 5563.8 5280.2 4972.6 4738.8 5087.6 1.10888573552267 0.018434372158814 0.149110711497932 Nonsignificant None 1 Biological Process:phosphatidylinositol phosphorylation (GO:0046854) myo-inositol-1(or 4)-monophosphatase 3.1.3.25 ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system Inositol monophosphatase G Carbohydrate transport and metabolism ; IPR000760 [Inositol monophosphatase-like] -- -- Q01730 Ras suppressor protein 1 Rsu1 5529.3 5728 5845.9 6743.7 6328.2 6332.8 0.881394713651847 0.00983935682580668 -0.182139851109698 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Ras suppressor protein (contains leucine-rich repeats) T Signal transduction mechanisms ; IPR001611 [Leucine-rich repeat] -- -- Q3U6P5 RRM domain-containing protein Hnrnpc 4321.9 4440.6 5620.9 4655.3 4679 4296.8 1.05518996999508 0.593279719534463 0.0775027563708558 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) heterogeneous nuclear ribonucleoprotein C1/C2 -- ko03040 Spliceosome FOG: RRM domain R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- A0A0R4J107 Acylamino-acid-releasing enzyme (Fragment) Apeh 3482.5 3109.9 3353.6 3672.9 3667.2 3608.6 0.908418351037109 0.0396810429844664 -0.138571244541791 Nonsignificant None 2 Biological Process:proteolysis (GO:0006508),Molecular Function:serine-type peptidase activity (GO:0008236) acylaminoacyl-peptidase 3.4.19.1 -- Dipeptidyl aminopeptidase O Posttranslational modification, protein turnover, chaperones ; IPR001375 [Peptidase S9, prolyl oligopeptidase, catalytic domain] -- -- Q8BSL7 ADP-ribosylation factor 2 Arf2 44.6 55.7 48.1 49.3 58.5 56.6 0.902676399026764 0.28384287864409 -0.147719207060879 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) uncharacterized protein -- -- GTP-binding ADP-ribosylation factor Arf1 U Intracellular trafficking, secretion, and vesicular transport ; IPR006689 [Small GTPase superfamily, ARF/SAR type] -- -- Q8BTZ7 Mannose-1-phosphate guanyltransferase beta Gmppb 5562.2 5351.9 5331.9 4958.7 5082.7 5131.6 1.07071772226982 0.0163935613064067 0.098578186569928 Nonsignificant None 2 Biological Process:biosynthetic process (GO:0009058),Molecular Function:nucleotidyltransferase activity (GO:0016779) mannose-1-phosphate guanylyltransferase 2.7.7.13 ko00051 Fructose and mannose metabolism ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways GDP-mannose pyrophosphorylase/mannose-1-phosphate guanylyltransferase M Cell wall/membrane/envelope biogenesis ; IPR001451 [Hexapeptide repeat] ; IPR005835[Nucleotidyl transferase domain] -- -- P62830 60S ribosomal protein L23 Rpl23 7582.5 7380.8 7517.5 6631.9 6807.4 6708.8 1.11577766638045 0.000574067435203573 0.158049579527278 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L23e -- ko03010 Ribosome 60S ribosomal protein L14/L17/L23 J Translation, ribosomal structure and biogenesis ; IPR000218 [Ribosomal protein L14P] -- -- P28660 Nck-associated protein 1 Nckap1 3163.4 2824.9 3021.2 2989.8 3016.7 3028.2 0.997210754092554 0.939803141169052 -0.00402965370221326 Nonsignificant None -- -- NCK-associated protein 1 -- ko04810 Regulation of actin cytoskeleton Membrane-associated hematopoietic protein R General function prediction only ; IPR019137 [Nck-associated protein 1] -- -- Q9WTP7 GTP:AMP phosphotransferase AK3, mitochondrial Ak3 5982.7 5867.5 6315.8 8201.9 8392.7 8946.3 0.711251365456973 0.000703893643938266 -0.491568577786438 Nonsignificant None 1 Molecular Function:adenylate kinase activity (GO:0004017) nucleoside-triphosphate--adenylate kinase 2.7.4.10 ko00230 Purine metabolism Adenylate kinase F Nucleotide transport and metabolism ; IPR007862 [Adenylate kinase, active site lid domain] -- -- Q8CC88 von Willebrand factor A domain-containing protein 8 Vwa8 3552.1 3448.3 4138.6 4537.6 4406.9 4568.2 0.824335625004625 0.0230014437730845 -0.278696250263569 Nonsignificant None 2 Molecular Function:ATP binding (GO:0005524),Molecular Function:ATPase activity (GO:0016887) -- -- -- AAA ATPase containing von Willebrand factor type A (vWA) domain R General function prediction only ; IPR011704 [ATPase, dynein-related, AAA domain] -- -- Q69Z71 Scinderin (Fragment) Scin 5154.2 4447.1 5007.9 10179.4 8903.7 10541.4 0.493145875879762 0.000761184336882265 -1.0199136262186 Significant down -- -- gelsolin -- ko04666 Fc gamma R-mediated phagocytosis ko04810 Regulation of actin cytoskeleton ko05203 Viral carcinogenesis Actin regulatory proteins (gelsolin/villin family) Z Cytoskeleton ; IPR007123 [Gelsolin-like domain] -- -- O35640 Annexin A8 Anxa8 7123.9 7826.8 4745.8 4041.9 4238.3 4301.2 1.56552529925128 0.12497012642611 0.646646822950831 Nonsignificant None 2 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:calcium-dependent phospholipid binding (GO:0005544) annexin A8 -- -- Annexin U Intracellular trafficking, secretion, and vesicular transport ; IPR018502 [Annexin repeat] -- -- A0A1Y7VNG3 Myosin XVB Myo15b 2506.6 2352.4 2472 2282.4 2544.6 2180.6 1.04614989440037 0.412849733592828 0.0650895785588752 Nonsignificant None 1 Cellular Component:cytoskeleton (GO:0005856) myosin XV -- -- Myosin VII, myosin IXB and related myosins N Cell motility ; IPR000857 [MyTH4 domain] ; IPR011511[Variant SH3 domain] ; IPR019748[FERM central domain] -- -- Q3UHZ3 DNA (cytosine-5)-methyltransferase Dnmt1 3825 4009.2 3898.5 3195.8 3338 3281.4 1.1953602575597 0.000699212752910081 0.257445483032042 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Molecular Function:chromatin binding (GO:0003682),Molecular Function:zinc ion binding (GO:0008270) DNA (cytosine-5)-methyltransferase 1 2.1.1.37 ko00270 Cysteine and methionine metabolism ko01100 Metabolic pathways ko05206 MicroRNAs in cancer -- -- -- IPR001025 [Bromo adjacent homology (BAH) domain] ; IPR002857[Zinc finger, CXXC-type] ; IPR010506[DMAP1-binding domain] ; IPR022702[DNA (cytosine-5)-methyltransferase 1, replication foci domain] ; IPR029063[S-adenosyl-L-methionine-dependent methyltransferase] -- -- E9PVG8 RIKEN cDNA 9530053A07 gene 9530053A07Rik 207.5 198.7 239.9 272.9 281.3 290.1 0.765249318962454 0.00802772646812892 -0.385998239068356 Nonsignificant None -- -- -- -- -- von Willebrand factor and related coagulation proteins WV Extracellular structures ; Defense mechanisms ; IPR001846 [von Willebrand factor, type D domain] ; IPR002919[Trypsin Inhibitor-like, cysteine rich domain] ; IPR014853[Uncharacterised domain, cysteine-rich] ; IPR025615[TILa domain] -- -- Q5FWK3 Rho GTPase-activating protein 1 Arhgap1 4612.2 4452.3 4622.5 4656.5 4950.4 4818.6 0.948805933936432 0.0719528874312221 -0.0758150622021251 Nonsignificant None 1 Biological Process:signal transduction (GO:0007165) Rho GTPase-activating protein 1 -- -- CDC42 Rho GTPase-activating protein TZ Signal transduction mechanisms ; Cytoskeleton ; IPR000198 [Rho GTPase-activating protein domain] ; IPR001251[CRAL-TRIO lipid binding domain] -- -- Q9WTX5 S-phase kinase-associated protein 1 Skp1 3878.5 3940.5 4487.6 4540.7 4657.5 4385.9 0.905956228237425 0.11114373521121 -0.142486747519075 Nonsignificant None 1 Biological Process:ubiquitin-dependent protein catabolic process (GO:0006511) S-phase kinase-associated protein 1 -- ko04110 Cell cycle ko04114 Oocyte meiosis ko04120 Ubiquitin mediated proteolysis ko04141 Protein processing in endoplasmic reticulum ko04310 Wnt signaling pathway ko04350 TGF-beta signaling pathway ko04710 Circadian rhythm ko05168 Herpes simplex infection ko05200 Pathways in cancer SCF ubiquitin ligase, Skp1 component O Posttranslational modification, protein turnover, chaperones ; IPR016072 [SKP1 component, dimerisation] ; IPR016073[SKP1 component, POZ domain] -- -- Q561N4 Ubiquitin-conjugating enzyme E2L 3 Ube2l3 2938.2 2862.6 2973.4 2920.4 2936.3 2811.3 1.01225196123673 0.526620723543098 0.0175684382366646 Nonsignificant None -- -- ubiquitin-conjugating enzyme E2 L3 2.3.2.23 ko04120 Ubiquitin mediated proteolysis ko05012 Parkinson's disease Ubiquitin-protein ligase O Posttranslational modification, protein turnover, chaperones ; IPR000608 [Ubiquitin-conjugating enzyme E2] -- -- Q3UC10 DNA replication licensing factor MCM6 Mcm6 5866 5796.8 5444.8 4538.7 4528.1 4701.2 1.2425624636839 0.00142716716572371 0.313318377970175 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Molecular Function:ATP binding (GO:0005524),Biological Process:DNA replication (GO:0006260) DNA replication licensing factor MCM6 3.6.4.12 ko03030 DNA replication ko04110 Cell cycle DNA replication licensing factor, MCM6 component L Replication, recombination and repair ; IPR001208 [MCM domain] ; IPR027925[MCM N-terminal domain] ; IPR033762[MCM OB domain] -- -- Q3UGT1 Carnitine O-palmitoyltransferase Cpt1a 7036.8 6411 7211.2 7210.2 6698.8 7647 0.958387455928744 0.460045703640662 -0.0613190696778471 Nonsignificant None -- -- carnitine O-palmitoyltransferase 1, liver isoform 2.3.1.21 ko00071 Fatty acid degradation ko01212 Fatty acid metabolism ko03320 PPAR signaling pathway ko04152 AMPK signaling pathway ko04920 Adipocytokine signaling pathway ko04922 Glucagon signaling pathway ko04931 Insulin resistance Carnitine O-acyltransferase CPTI I Lipid transport and metabolism ; IPR000542 [Acyltransferase ChoActase/COT/CPT] ; IPR032476[Carnitine O-palmitoyltransferase, N-terminal] -- -- Q8CAJ7 Aspartyl aminopeptidase Dnpep 3487.8 3358.5 3553.1 3464.4 3428.7 3390.5 1.01126064802209 0.561433807408408 0.0161548935257529 Nonsignificant None 3 Molecular Function:aminopeptidase activity (GO:0004177),Biological Process:proteolysis (GO:0006508),Molecular Function:zinc ion binding (GO:0008270) aspartyl aminopeptidase 3.4.11.21 -- Aminopeptidase I zinc metalloprotease (M18) E Amino acid transport and metabolism ; IPR001948 [Peptidase M18] -- -- A0A1C7CYV0 Plastin-3 (Fragment) Pls3 2279.3 2147.9 2240.3 2120.6 2103.3 2161 1.04426067753606 0.0912202934319381 0.0624818950923455 Nonsignificant None 2 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:protein binding (GO:0005515) plastin-3 -- -- Ca2+-binding actin-bundling protein (fimbrin/plastin), EF-Hand protein superfamily Z Cytoskeleton ; IPR001715 [Calponin homology domain] ; IPR002048[EF-hand domain] -- -- Q8R016 Bleomycin hydrolase Blmh 4919.7 4935.5 4198.5 4216.7 4089.8 4123.8 1.130600226865 0.152936015725526 0.177088891595598 Nonsignificant None 2 Molecular Function:cysteine-type endopeptidase activity (GO:0004197),Biological Process:proteolysis (GO:0006508) bleomycin hydrolase 3.4.22.40 -- Bleomycin hydrolases and aminopeptidases of cysteine protease family E Amino acid transport and metabolism ; IPR004134 [Peptidase C1B, bleomycin hydrolase] -- -- Q8C483 Serine--tRNA ligase Sars 6567.6 6413.5 5967.9 5699.6 5895.1 5826.3 1.08771023477412 0.0541425731513165 0.121294274848722 Nonsignificant None 4 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation for protein translation (GO:0006418) seryl-tRNA synthetase 6.1.1.11 ko00970 Aminoacyl-tRNA biosynthesis Seryl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR002314 [Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)] ; IPR015866[Serine-tRNA synthetase, type1, N-terminal] -- -- Q3THU8 Phosphate carrier protein, mitochondrial Slc25a3 9774.6 9391.2 7457.9 7583.2 7490.4 7825.7 1.16264252619076 0.22378145165405 0.217407584370938 Nonsignificant None -- -- solute carrier family 25 (mitochondrial phosphate transporter), member 3 -- -- Mitochondrial phosphate carrier protein C Energy production and conversion ; IPR018108 [Mitochondrial substrate/solute carrier] -- -- A0A0R4J2D3 Transport and Golgi organization protein 1 homolog Mia3 3560.4 3771.2 4378.8 4483.3 4352.2 4098.2 0.905417629912554 0.205664483399947 -0.14334469647503 Nonsignificant None -- -- -- -- -- -- -- -- IPR011511 [Variant SH3 domain] -- -- Q62418 Drebrin-like protein Dbnl 4555.3 4633 4378.2 4214.6 4438.7 4430 1.03693257817217 0.200337984503889 0.0523220925129265 Nonsignificant None 3 Molecular Function:actin binding (GO:0003779),Molecular Function:protein binding (GO:0005515),Cellular Component:intracellular (GO:0005622) drebrin-like protein -- -- Drebrins and related actin binding proteins Z Cytoskeleton ; IPR001452 [SH3 domain] ; IPR002108[Actin-depolymerising factor homology domain] -- -- P97310 DNA replication licensing factor MCM2 Mcm2 2643.3 2695.2 2785.2 2456 2531.5 2468.5 1.08955203862661 0.00946578848212392 0.123735103361252 Nonsignificant None 7 Molecular Function:DNA binding (GO:0003677),Molecular Function:DNA helicase activity (GO:0003678),Molecular Function:ATP binding (GO:0005524),Cellular Component:nucleus (GO:0005634),Biological Process:DNA replication (GO:0006260),Biological Process:DNA replication initiation (GO:0006270),Cellular Component:MCM complex (GO:0042555) DNA replication licensing factor MCM2 3.6.4.12 ko03030 DNA replication ko04110 Cell cycle DNA replication licensing factor, MCM2 component L Replication, recombination and repair ; IPR001208 [MCM domain] ; IPR008045[DNA replication licensing factor Mcm2] ; IPR027925[MCM N-terminal domain] ; IPR033762[MCM OB domain] -- -- Q93092 Transaldolase Taldo1 11862.1 12707.3 15482.7 13528.9 13293.3 12819.8 1.01034508854245 0.908194219904064 0.0148481370328033 Nonsignificant None 1 Biological Process:carbohydrate metabolic process (GO:0005975) transaldolase 2.2.1.2 ko00030 Pentose phosphate pathway ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids Transaldolase G Carbohydrate transport and metabolism ; IPR001585 [Transaldolase/Fructose-6-phosphate aldolase] -- -- Q7TSV4 Phosphopentomutase Pgm2 5779.2 5630.7 6810.9 7298.5 6674.7 7110 0.864233133490172 0.0827969468961584 -0.210507551988384 Nonsignificant None 2 Biological Process:carbohydrate metabolic process (GO:0005975),Biological Process:organic substance metabolic process (GO:0071704) -- -- ko00010 Glycolysis / Gluconeogenesis ko00030 Pentose phosphate pathway ko00052 Galactose metabolism ko00230 Purine metabolism ko00500 Starch and sucrose metabolism ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways Phosphoglucomutase/phosphomannomutase G Carbohydrate transport and metabolism ; IPR005843 [Alpha-D-phosphohexomutase, C-terminal] ; IPR005844[Alpha-D-phosphohexomutase, alpha/beta/alpha domain I] ; IPR005845[Alpha-D-phosphohexomutase, alpha/beta/alpha domain II] ; IPR005846[Alpha-D-phosphohexomutase, alpha/beta/alpha domain III] -- -- Q925I1 ATPase family AAA domain-containing protein 3 Atad3 3594.9 3525.1 3517.1 3526.5 3449.3 3533.8 1.01213176524321 0.310396440971226 0.0173971207520088 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) ATPase family AAA domain-containing protein 3A/B -- -- AAA+-type ATPase O Posttranslational modification, protein turnover, chaperones ; IPR003959 [ATPase, AAA-type, core] ; IPR021911[ATPase family AAA domain-containing protein 3, domain of unknown function DUF3523] -- -- Q99JX4 Eukaryotic translation initiation factor 3 subunit M Eif3m 2957.1 2796.2 3528.1 3107.3 3251 3370.8 0.953983410592963 0.559535796257974 -0.0679639163540165 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) translation initiation factor 3 subunit M -- -- Uncharacterized conserved protein, contains PCI domain R General function prediction only ; IPR000717 [Proteasome component (PCI) domain] -- -- Q91VC3 Eukaryotic initiation factor 4A-III Eif4a3 4311.4 4189.9 4554.9 4158.3 3993.8 4384.6 1.04143833704244 0.329324790287825 0.0585774207739686 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase 3.6.4.13 ko03013 RNA transport ko03015 mRNA surveillance pathway ko03040 Spliceosome Predicted ATP-dependent RNA helicase FAL1, involved in rRNA maturation, DEAD-box superfamily J Translation, ribosomal structure and biogenesis ; IPR001650 [Helicase, C-terminal] ; IPR011545[DEAD/DEAH box helicase domain] -- -- E9PV41 Protein diaphanous homolog 1 Diaph1 3270.7 3105.3 3025.9 3557.2 3541.5 3564.7 0.881698145056924 0.0272638724769316 -0.181643270358987 Nonsignificant None 4 Molecular Function:actin binding (GO:0003779),Biological Process:cellular component organization (GO:0016043),Molecular Function:Rho GTPase binding (GO:0017048),Biological Process:actin cytoskeleton organization (GO:0030036) diaphanous 1 -- ko04510 Focal adhesion ko04810 Regulation of actin cytoskeleton ko04933 AGE-RAGE signaling pathway in diabetic complications RhoA GTPase effector DIA/Diaphanous TZ Signal transduction mechanisms ; Cytoskeleton ; IPR009408 [Formin Homology 1] ; IPR010465[DRF autoregulatory] ; IPR010472[Formin, FH3 domain] ; IPR010473[Formin, GTPase-binding domain] ; IPR015425[Formin, FH2 domain] -- -- Q8CGP0 Histone H2B type 3-B H2bu1 402.2 392 453.3 480.9 498.1 525 0.829454787234043 0.0202253546197266 -0.269764751453015 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) histone H2B -- ko05034 Alcoholism ko05203 Viral carcinogenesis ko05322 Systemic lupus erythematosus Histone H2B B Chromatin structure and dynamics ; IPR007125 [Histone H2A/H2B/H3] -- -- Q9D2G2 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial Dlst 5095 4930.3 5254.7 5573.4 5374.2 5454.7 0.931576669125671 0.0273164680564446 -0.10225358646587 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) 2.3.1.61 ko00020 Citrate cycle (TCA cycle) ko00310 Lysine degradation ko01100 Metabolic pathways ko01200 Carbon metabolism Dihydrolipoamide succinyltransferase (2-oxoglutarate dehydrogenase, E2 subunit) C Energy production and conversion ; IPR000089 [Biotin/lipoyl attachment] ; IPR001078[2-oxoacid dehydrogenase acyltransferase, catalytic domain] -- -- Q04750 DNA topoisomerase 1 Top1 7376.7 7357.7 7261.2 6550.9 6484.8 6460.4 1.12820512820513 0.0000493174624332196 0.174029399775049 Nonsignificant None 4 Molecular Function:DNA binding (GO:0003677),Molecular Function:DNA topoisomerase type I activity (GO:0003917),Cellular Component:chromosome (GO:0005694),Biological Process:DNA topological change (GO:0006265) DNA topoisomerase I 5.99.1.2 -- DNA topoisomerase I L Replication, recombination and repair ; IPR008336 [DNA topoisomerase I, DNA binding, eukaryotic-type] ; IPR013500[DNA topoisomerase I, catalytic core, eukaryotic-type] ; IPR025834[Topoisomerase I C-terminal domain] -- -- Q0PD54 Rab6A Rab6a 146.4 139 145.1 154.3 147.6 161.1 0.929805615550756 0.0744319330393247 -0.104998955863392 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-6A -- -- GTPase Rab6/YPT6/Ryh1, small G protein superfamily U Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- Q3U1S6 Uncharacterized protein Csde1 8864.3 9201.2 9063 7526.6 7568.8 7298.1 1.2114452854623 0.000255915117888959 0.276729247401932 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) -- -- -- -- -- -- IPR002059 [Cold-shock protein, DNA-binding] ; IPR024642[SUZ-C domain] -- CSD P70336 Rho-associated protein kinase 2 Rock2 4961.7 4993.4 5397.3 5384.1 5485.9 5276.4 0.950824951692018 0.158092399651335 -0.072748331689047 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468),Molecular Function:Rho GTPase binding (GO:0017048) Rho-associated protein kinase 2 2.7.11.1 ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04062 Chemokine signaling pathway ko04071 Sphingolipid signaling pathway ko04270 Vascular smooth muscle contraction ko04310 Wnt signaling pathway ko04360 Axon guidance ko04510 Focal adhesion ko04530 Tight junction ko04611 Platelet activation ko04670 Leukocyte transendothelial migration ko04810 Regulation of actin cytoskeleton ko04921 Oxytocin signaling pathway ko05132 Salmonella infection ko05200 Pathways in cancer ko05205 Proteoglycans in cancer Rho-associated, coiled-coil containing protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR015008[Rho binding domain] -- -- Q6ZPH4 MKIAA1835 protein (Fragment) Rangap1 4571.5 4736.6 4756.8 4182.3 4550.6 4368.8 1.07351717716022 0.0573569747576807 0.102345275691886 Nonsignificant None 3 Molecular Function:GTPase activator activity (GO:0005096),Molecular Function:protein binding (GO:0005515),Biological Process:signal transduction (GO:0007165) Ran GTPase-activating protein 1 -- ko03013 RNA transport Ran GTPase-activating protein AYT RNA processing and modification ; Nuclear structure ; Signal transduction mechanisms ; IPR001611 [Leucine-rich repeat] ; IPR009109[Ran-GTPase activating protein 1, C-terminal] -- -- Q8R5G0 Nidogen 2 protein Nid2 3001.1 2854.6 2894.5 3085.5 3113.3 3230.8 0.927950284211419 0.0221849970118437 -0.10788058117564 Nonsignificant None 2 Molecular Function:calcium ion binding (GO:0005509),Biological Process:cell-matrix adhesion (GO:0007160) nidogen (entactin) -- -- Nidogen and related basement membrane protein proteins MW Cell wall/membrane/envelope biogenesis ; Extracellular structures ; IPR000033 [LDLR class B repeat] ; IPR000716[Thyroglobulin type-1] ; IPR001881[EGF-like calcium-binding domain] ; IPR003886[NIDO domain] ; IPR006605[G2 nidogen/fibulin G2F] -- -- Q543C5 Mimecan Ogn 5530.2 5729.9 6691.1 8583.6 8771.4 9161.8 0.676974597236469 0.00197588082482655 -0.56282639569353 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) osteoglycin (osteoinductive factor, mimecan) -- -- FOG: Leucine rich repeat R General function prediction only ; IPR001611 [Leucine-rich repeat] -- -- Q921G7 Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial Etfdh 4523.4 4500.1 5834.7 6555.8 6087 6682.7 0.768839098600295 0.0354180675107549 -0.379246389989987 Nonsignificant None -- -- electron-transferring-flavoprotein dehydrogenase 1.5.5.1 -- Electron transfer flavoprotein ubiquinone oxidoreductase C Energy production and conversion ; -- -- -- Q6IRT4 Eukaryotic translation initiation factor 3 subunit F Eif3f 5965.6 6134 5654.2 4627.6 4827.7 4673.8 1.25654146407061 0.00139098704981118 0.32945827887638 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) translation initiation factor 3 subunit F -- ko03013 RNA transport Translation initiation factor 3, subunit f (eIF-3f) J Translation, ribosomal structure and biogenesis ; IPR000555 [JAB1/MPN/MOV34 metalloenzyme domain] ; IPR024969[Rpn11/EIF3F, C-terminal] -- -- Q3UE92 Xaa-Pro aminopeptidase 1 Xpnpep1 5834.4 5820.9 6280.9 5788.7 5545.3 5829.3 1.04503213251531 0.215438558154588 0.0635473027920756 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) Xaa-Pro aminopeptidase 3.4.11.9 -- Xaa-Pro aminopeptidase E Amino acid transport and metabolism ; IPR000587 [Creatinase, N-terminal] ; IPR000994[Peptidase M24] ; IPR032416[Peptidase M24, C-terminal domain] -- -- P21614 Vitamin D-binding protein Gc 6321.6 6280.3 4729.6 3167.7 3715.2 3299.4 1.70212034609077 0.0122674266068477 0.76733304440949 Significant up 1 Cellular Component:extracellular space (GO:0005615) vitamin D-binding protein -- -- -- -- -- IPR014760 [Serum albumin, N-terminal] ; IPR015247[Vitamin D binding protein, domain III] -- -- Q9CQ60 6-phosphogluconolactonase Pgls 4798 4983.5 3782.5 3821 3869.6 4111.3 1.14930646760267 0.200777958920544 0.200763550234802 Nonsignificant None 1 Biological Process:carbohydrate metabolic process (GO:0005975) 6-phosphogluconolactonase 3.1.1.31 ko00030 Pentose phosphate pathway ko01100 Metabolic pathways ko01200 Carbon metabolism 6-phosphogluconolactonase - like protein G Carbohydrate transport and metabolism ; IPR006148 [Glucosamine/galactosamine-6-phosphate isomerase] -- -- E9PV24 Fibrinogen alpha chain Fga 13558.5 15448.4 11552.6 6344.4 6816.4 6250.6 2.08946804455114 0.022351668322254 1.06313569485552 Significant up 5 Molecular Function:receptor binding (GO:0005102),Cellular Component:fibrinogen complex (GO:0005577),Biological Process:signal transduction (GO:0007165),Biological Process:platelet activation (GO:0030168),Biological Process:protein polymerization (GO:0051258) fibrinogen alpha chain -- ko04610 Complement and coagulation cascades ko04611 Platelet activation -- -- -- IPR002181 [Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain] ; IPR012290[Fibrinogen, alpha/beta/gamma chain, coiled coil domain] ; IPR021996[Fibrinogen alpha C domain] -- -- P45952 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial Acadm 4399.6 4147.6 5506.3 6505.8 5946.4 6768.6 0.731161033879963 0.0233961797791429 -0.451738908690084 Nonsignificant None 4 Molecular Function:acyl-CoA dehydrogenase activity (GO:0003995),Biological Process:metabolic process (GO:0008152),Molecular Function:flavin adenine dinucleotide binding (GO:0050660),Biological Process:oxidation-reduction process (GO:0055114) acyl-CoA dehydrogenase 1.3.8.7 ko00071 Fatty acid degradation ko00280 Valine, leucine and isoleucine degradation ko00410 beta-Alanine metabolism ko00640 Propanoate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01212 Fatty acid metabolism ko03320 PPAR signaling pathway Medium-chain acyl-CoA dehydrogenase I Lipid transport and metabolism ; IPR006091 [Acyl-CoA oxidase/dehydrogenase, central domain] ; IPR009075[Acyl-CoA dehydrogenase/oxidase C-terminal] ; IPR013786[Acyl-CoA dehydrogenase/oxidase, N-terminal] -- -- Q3UKA1 J domain-containing protein Dnajc3 5213 5122.3 3946.8 4163.8 4258 3742.6 1.17408996744599 0.181931534415294 0.231542962634588 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) DnaJ homolog subfamily C member 3 -- ko04141 Protein processing in endoplasmic reticulum ko05164 Influenza A dsRNA-activated protein kinase inhibitor P58, contains TPR and DnaJ domains V Defense mechanisms ; IPR001440 [Tetratricopeptide repeat 1] ; IPR001623[DnaJ domain] ; IPR019734[Tetratricopeptide repeat] -- -- Q8BH95 Enoyl-CoA hydratase, mitochondrial Echs1 5900.9 5690.7 7512 8861.2 8553.4 9079.3 0.721056545091512 0.014386767277054 -0.471815695165523 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) enoyl-CoA hydratase 4.2.1.17 ko00062 Fatty acid elongation ko00071 Fatty acid degradation ko00280 Valine, leucine and isoleucine degradation ko00310 Lysine degradation ko00380 Tryptophan metabolism ko00410 beta-Alanine metabolism ko00640 Propanoate metabolism ko00650 Butanoate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01212 Fatty acid metabolism Enoyl-CoA hydratase I Lipid transport and metabolism ; IPR001753 [Crotonase superfamily] -- -- Q3UEB3 Poly(U)-binding-splicing factor PUF60 Puf60 3449.3 3498 3470.1 3057.4 3162.6 3125.3 1.11472076872867 0.000456541061676677 0.156682368422284 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) poly(U)-binding-splicing factor PUF60 -- ko03040 Spliceosome Polypyrimidine tract-binding protein PUF60 (RRM superfamily) A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- Q61166 Microtubule-associated protein RP/EB family member 1 Mapre1 3833.1 3850.4 3382.8 3049.7 3166.3 3206.2 1.17449215682112 0.0267069179410506 0.232037079162754 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:microtubule binding (GO:0008017) microtubule-associated protein, RP/EB family -- -- Microtubule-binding protein involved in cell cycle control DZ Cell cycle control, cell division, chromosome partitioning ; Cytoskeleton ; IPR001715 [Calponin homology domain] ; IPR004953[EB1, C-terminal] -- -- P99026 Proteasome subunit beta type-4 Psmb4 4322 4337.8 4595.5 4415.3 4509.9 4371.4 0.996893942812448 0.894664369674244 -0.00448806701146563 Nonsignificant None 3 Molecular Function:threonine-type endopeptidase activity (GO:0004298),Cellular Component:proteasome core complex (GO:0005839),Biological Process:proteolysis involved in cellular protein catabolic process (GO:0051603) 20S proteasome subunit beta 7 3.4.25.1 ko03050 Proteasome 20S proteasome, regulatory subunit beta type PSMB4/PRE4 O Posttranslational modification, protein turnover, chaperones ; IPR001353 [Proteasome, subunit alpha/beta] -- -- Q3V3W7 TGc domain-containing protein F13a1 3159.5 3677.3 3117.4 2853.5 3206.4 2894.3 1.11167943534877 0.190538382051583 0.152740831491009 Nonsignificant None 2 Molecular Function:protein-glutamine gamma-glutamyltransferase activity (GO:0003810),Biological Process:peptide cross-linking (GO:0018149) coagulation factor XIII A1 polypeptide 2.3.2.13 ko04610 Complement and coagulation cascades -- -- -- IPR001102 [Transglutaminase, N-terminal] ; IPR002931[Transglutaminase-like] ; IPR008958[Transglutaminase, C-terminal] -- -- A0A0N4SV32 Plasminogen activator inhibitor 1 RNA-binding protein Serbp1 6660.4 6620.8 6428.1 5262.4 5385.6 5098.7 1.25164637670115 0.000273625905261527 0.32382702022487 Nonsignificant None -- -- plasminogen activator inhibitor 1 RNA-binding protein -- -- Predicted RNA-binding protein R General function prediction only ; IPR006861 [Hyaluronan/mRNA-binding protein] ; IPR032381[Intracellular hyaluronan-binding protein 4, N-terminal domain] -- -- Q9DCN2 NADH-cytochrome b5 reductase 3 Cyb5r3 3326.8 3401.9 3426.2 3738.2 3849.9 3829.9 0.889376423191452 0.000763505733463535 -0.169133934627461 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) cytochrome-b5 reductase 1.6.2.2 ko00520 Amino sugar and nucleotide sugar metabolism NADH-cytochrome b-5 reductase HC Coenzyme transport and metabolism ; Energy production and conversion ; IPR001433 [Oxidoreductase FAD/NAD(P)-binding] ; IPR008333[Oxidoreductase, FAD-binding domain] -- -- Q5PPQ7 Coronin Coro1c 6856 6991.7 5939.1 6349 6027.2 6217.9 1.06414400266751 0.311548706720477 0.0896933932046119 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) coronin-1B/1C/6 -- -- Actin-binding protein Coronin, contains WD40 repeats Z Cytoskeleton ; IPR001680 [WD40 repeat] ; IPR015048[Domain of unknown function DUF1899] -- -- Q6IMF0 Keratin, type II cuticular 87 Krt87 1274.5 1137.2 1075.1 945.6 938.4 901.8 1.25163328307847 0.018064218243352 0.323811927940287 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) type II keratin, basic -- -- -- -- -- IPR001664 [Intermediate filament protein] ; IPR032444[Keratin type II head] -- -- Q99KQ4 Nicotinamide phosphoribosyltransferase Nampt 4455 4352.1 4399.4 4417 4652.7 4531 0.971016197695707 0.151561358106525 -0.0424327331869078 Nonsignificant None -- -- nicotinamide phosphoribosyltransferase 2.4.2.12 ko00760 Nicotinate and nicotinamide metabolism ko01100 Metabolic pathways ko04621 NOD-like receptor signaling pathway -- -- -- IPR007229 [Nicotinate phosphoribosyltransferase family] -- -- Q921D5 DNA replication licensing factor MCM4 Mcm4 2102.8 2079 2090.9 1882.6 1856 1819.2 1.12863003346648 0.000263829197587616 0.174572646114926 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Molecular Function:ATP binding (GO:0005524),Biological Process:DNA replication (GO:0006260) DNA replication licensing factor MCM4 3.6.4.12 ko03030 DNA replication ko04110 Cell cycle DNA replication licensing factor, MCM4 component L Replication, recombination and repair ; IPR001208 [MCM domain] ; IPR027925[MCM N-terminal domain] ; IPR033762[MCM OB domain] -- -- Q3KQQ1 NSFL1 cofactor p47 (Fragment) Nsfl1c 3621.9 3765.7 3394 3389.1 3407.9 3154.7 1.08339278716199 0.11062871692242 0.115556391010893 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) UBX domain-containing protein 1 -- ko04141 Protein processing in endoplasmic reticulum Protein tyrosine phosphatase SHP1/Cofactor for p97 ATPase-mediated vesicle membrane fusion Y Nuclear structure ; IPR001012 [UBX domain] ; IPR012989[SEP domain] -- -- Q8C6E3 Catalase Cat 3567.8 3546.7 5240.7 3913.6 4103.1 4032.6 1.02538736690098 0.872889043507671 0.036169028494835 Nonsignificant None 3 Molecular Function:catalase activity (GO:0004096),Molecular Function:heme binding (GO:0020037),Biological Process:oxidation-reduction process (GO:0055114) catalase 1.11.1.6 ko00380 Tryptophan metabolism ko00630 Glyoxylate and dicarboxylate metabolism ko01200 Carbon metabolism ko04068 FoxO signaling pathway ko04146 Peroxisome ko04211 Longevity regulating pathway ko04213 Longevity regulating pathway - multiple species ko05014 Amyotrophic lateral sclerosis (ALS) Catalase P Inorganic ion transport and metabolism ; IPR010582 [Catalase immune-responsive domain] ; IPR011614[Catalase core domain] -- -- Q9Z2U1 Proteasome subunit alpha type-5 Psma5 3527.2 3467.4 4111.7 4086 4045.3 4000.3 0.915485179201424 0.237050832557228 -0.127391564479913 Nonsignificant None 5 Molecular Function:endopeptidase activity (GO:0004175),Molecular Function:threonine-type endopeptidase activity (GO:0004298),Cellular Component:proteasome core complex (GO:0005839),Biological Process:ubiquitin-dependent protein catabolic process (GO:0006511),Biological Process:proteolysis involved in cellular protein catabolic process (GO:0051603) 20S proteasome subunit alpha 5 3.4.25.1 ko03050 Proteasome 20S proteasome, regulatory subunit alpha type PSMA5/PUP2 O Posttranslational modification, protein turnover, chaperones ; IPR000426 [Proteasome alpha-subunit, N-terminal domain] ; IPR001353[Proteasome, subunit alpha/beta] -- -- Q543K9 Purine nucleoside phosphorylase Pnp 4736.2 4734 4787.3 5272.6 5327.8 4817.1 0.924760823739257 0.137873404166997 -0.11284781360831 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:nucleoside metabolic process (GO:0009116) purine-nucleoside phosphorylase 2.4.2.1 ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko00760 Nicotinate and nicotinamide metabolism ko01100 Metabolic pathways Purine nucleoside phosphorylase F Nucleotide transport and metabolism ; IPR000845 [Nucleoside phosphorylase domain] -- -- Q2KHK6 Gasdermin-C2 Gsdmc2 1354.1 951 1117.4 1331.3 1284.7 1320.2 0.869493420049794 0.279931464251299 -0.201752985006391 Nonsignificant None -- -- gasdermin-C -- -- -- -- -- IPR007677 [Gasdermin] -- -- Q99MR6 Serrate RNA effector molecule homolog Srrt 5381.8 5393 5605.3 5486.5 5392.9 5569.6 0.995811295519485 0.808747188295838 -0.00605571485443719 Nonsignificant None -- -- -- -- -- C2H2 Zn-finger protein R General function prediction only ; IPR007042 [Arsenite-resistance protein 2] ; IPR021933[Protein of unknown function DUF3546] -- -- Q8BMD8 Calcium-binding mitochondrial carrier protein SCaMC-1 Slc25a24 4495 4097.8 5062.1 5842 5264.7 5924.9 0.801739120223584 0.0319634203535454 -0.318795223777011 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) solute carrier family 25 (mitochondrial phosphate transporter), member 23/24/25/41 -- -- Predicted mitochondrial carrier protein F Nucleotide transport and metabolism ; IPR002048 [EF-hand domain] ; IPR018108[Mitochondrial substrate/solute carrier] -- -- Q3UZ39 Leucine-rich repeat flightless-interacting protein 1 Lrrfip1 1455 1641.3 1296.6 1117.2 1114.1 1018.9 1.35157836440834 0.0220094235733611 0.434645161643787 Nonsignificant None -- -- -- -- -- Double stranded RNA binding protein R General function prediction only ; IPR019139 [Leucine-rich repeat flightless-interacting protein 1/2] -- -- Q8BMA6 Signal recognition particle subunit SRP68 Srp68 3807.8 3845.1 3392.9 3339.9 3313.3 3176 1.12377406096122 0.0575252562083807 0.168352005401846 Nonsignificant None 4 Molecular Function:signal recognition particle binding (GO:0005047),Biological Process:SRP-dependent cotranslational protein targeting to membrane (GO:0006614),Molecular Function:7S RNA binding (GO:0008312),Molecular Function:endoplasmic reticulum signal peptide binding (GO:0030942) signal recognition particle subunit SRP68 -- ko03060 Protein export Signal recognition particle, subunit Srp68 U Intracellular trafficking, secretion, and vesicular transport ; IPR026258 [Signal recognition particle subunit SRP68] -- -- P19639 Glutathione S-transferase Mu 3 Gstm3 1718.6 1521.5 1543.3 2869.7 2627.6 3014.9 0.561946382838749 0.000649759286358106 -0.83149561017566 Significant down 1 Molecular Function:protein binding (GO:0005515) glutathione S-transferase 2.5.1.18 ko00480 Glutathione metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko01524 Platinum drug resistance ko05200 Pathways in cancer ko05204 Chemical carcinogenesis ko05225 Hepatocellular carcinoma ko05418 Fluid shear stress and atherosclerosis Glutathione S-transferase O Posttranslational modification, protein turnover, chaperones ; IPR004045 [Glutathione S-transferase, N-terminal] ; IPR004046[Glutathione S-transferase, C-terminal] -- -- Q569Z5 Probable ATP-dependent RNA helicase DDX46 Ddx46 5285.6 5285.1 4594.2 4189.4 4264.8 4277 1.1911602991077 0.070079534775782 0.252367575390171 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase DDX46/PRP5 3.6.4.13 ko03040 Spliceosome RNA helicase A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR011545[DEAD/DEAH box helicase domain] -- -- Q3TEA8 Heterochromatin protein 1-binding protein 3 Hp1bp3 5130.5 5136 5498.9 5692.1 5450 5907 0.924705702940331 0.0758623381420704 -0.11293380868001 Nonsignificant None 4 Cellular Component:nucleosome (GO:0000786),Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634),Biological Process:nucleosome assembly (GO:0006334) -- -- -- Histone H1 B Chromatin structure and dynamics ; IPR005818 [Linker histone H1/H5, domain H15] -- -- Q3TQ70 Beta1 subnuit of GTP-binding protein Gnb1 1061.9 1087.6 1493.8 1503.7 1469.3 1431.1 0.827251878930996 0.209402035038937 -0.273601431563387 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 -- ko04014 Ras signaling pathway ko04062 Chemokine signaling pathway ko04151 PI3K-Akt signaling pathway ko04371 Apelin signaling pathway ko04713 Circadian entrainment ko04723 Retrograde endocannabinoid signaling ko04724 Glutamatergic synapse ko04725 Cholinergic synapse ko04726 Serotonergic synapse ko04727 GABAergic synapse ko04728 Dopaminergic synapse ko04740 Olfactory transduction ko04744 Phototransduction ko04926 Relaxin signaling pathway ko05032 Morphine addiction ko05034 Alcoholism ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05200 Pathways in cancer G-protein beta subunit R General function prediction only ; IPR001680 [WD40 repeat] -- -- O55222 Integrin-linked protein kinase Ilk 8855 9001.9 8739.1 9857.6 9352.7 9331 0.93184262805128 0.0261134657195537 -0.10184176543746 Nonsignificant None 2 Molecular Function:protein kinase activity (GO:0004672),Biological Process:protein phosphorylation (GO:0006468) integrin-linked kinase 2.7.11.1 ko03320 PPAR signaling pathway ko04360 Axon guidance ko04510 Focal adhesion ko05100 Bacterial invasion of epithelial cells ko05213 Endometrial cancer Integrin-linked kinase T Signal transduction mechanisms ; IPR001245 [Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR020683[Ankyrin repeat-containing domain] -- -- Q3THW7 Eukaryotic translation initiation factor 3 subunit H Eif3h 4595.1 4711.9 3534.4 3164 3258.7 3219.7 1.33176387621339 0.103629043494874 0.413338313029681 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) translation initiation factor 3 subunit H -- ko03013 RNA transport ko05162 Measles Translation initiation factor 3, subunit h (eIF-3h) J Translation, ribosomal structure and biogenesis ; IPR000555 [JAB1/MPN/MOV34 metalloenzyme domain] -- -- O09131 Glutathione S-transferase omega-1 Gsto1 5278.5 4684.5 5254.4 7120 8143.8 7906.1 0.656774522117057 0.0019131380866761 -0.606529932339714 Significant down 1 Molecular Function:protein binding (GO:0005515) glutathione S-transferase 2.5.1.18 ko00480 Glutathione metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko01524 Platinum drug resistance ko05200 Pathways in cancer ko05204 Chemical carcinogenesis ko05225 Hepatocellular carcinoma ko05418 Fluid shear stress and atherosclerosis Glutathione S-transferase O Posttranslational modification, protein turnover, chaperones ; IPR004045 [Glutathione S-transferase, N-terminal] ; IPR004046[Glutathione S-transferase, C-terminal] -- -- Q9DBG5 Perilipin-3 Plin3 3944 3953.6 4195.2 3700.1 3936 3618.2 1.07450485592174 0.0904549569512548 0.103672002633894 Nonsignificant None -- -- perilipin-3 -- -- -- -- -- IPR004279 [Perilipin] -- -- Q9D8W5 26S proteasome non-ATPase regulatory subunit 12 Psmd12 3486 3520.6 3537.7 3327.7 3595.6 3433 1.01815320143294 0.474080606986487 0.0259546599578899 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) 26S proteasome regulatory subunit N5 -- ko03050 Proteasome ko05169 Epstein-Barr virus infection 26S proteasome regulatory complex, subunit RPN5/PSMD12 O Posttranslational modification, protein turnover, chaperones ; IPR000717 [Proteasome component (PCI) domain] -- -- Q569X4 26S proteasome regulatory subunit 6B Psmc4 6042.2 5795.1 4615 4316.6 4469.8 4538.6 1.23469418386492 0.138662217931979 0.304153751076025 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) 26S proteasome regulatory subunit T3 -- ko03050 Proteasome ko05169 Epstein-Barr virus infection 26S proteasome regulatory complex, ATPase RPT3 O Posttranslational modification, protein turnover, chaperones ; IPR003959 [ATPase, AAA-type, core] -- -- A1L0V4 Histone H3 (Fragment) Hist1h3i 1149.5 1530.8 1016.6 1202.6 1035 1361.7 1.02711638374128 0.865856214494258 0.0385996643564048 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) histone H3 -- ko05034 Alcoholism ko05202 Transcriptional misregulation in cancer ko05322 Systemic lupus erythematosus Histones H3 and H4 B Chromatin structure and dynamics ; IPR007125 [Histone H2A/H2B/H3] -- -- A0A3B2W864 Predicted gene, 49804 Gm49804 9223.6 9041.7 8743.5 6788.9 7063.5 7277.1 1.27825078681464 0.00059478095047449 0.354170914061809 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) small subunit ribosomal protein S10e -- ko03010 Ribosome 40s ribosomal protein s10 J Translation, ribosomal structure and biogenesis ; IPR000086 [NUDIX hydrolase domain] ; IPR005326[Plectin/S10, N-terminal] -- -- Q91VA7 Isocitrate dehydrogenase [NAD] subunit, mitochondrial Idh3b 4062.5 3767.6 4537.8 5575 5314.4 5987.6 0.732825739171654 0.0072546103652686 -0.448457918522421 Nonsignificant None 1 Biological Process:oxidation-reduction process (GO:0055114) isocitrate dehydrogenase (NAD+) 1.1.1.41 ko00020 Citrate cycle (TCA cycle) ko01100 Metabolic pathways ko01200 Carbon metabolism ko01210 2-Oxocarboxylic acid metabolism ko01230 Biosynthesis of amino acids Isocitrate dehydrogenase, gamma subunit E Amino acid transport and metabolism ; IPR024084 [Isopropylmalate dehydrogenase-like domain] -- -- Q8QZY1 Eukaryotic translation initiation factor 3 subunit L Eif3l 6710.1 7273.3 7137 5887.8 6262 6115.6 1.15630645920703 0.0091633758727492 0.209523810108417 Nonsignificant None 3 Molecular Function:translation initiation factor activity (GO:0003743),Cellular Component:cytoplasm (GO:0005737),Cellular Component:eukaryotic translation initiation factor 3 complex (GO:0005852) translation initiation factor 3 subunit L -- -- RNA polymerase I-associated factor - PAF67 JK Translation, ribosomal structure and biogenesis ; Transcription ; IPR019382 [Translation initiation factor 3 complex subunit L] -- -- B2RQQ8 Collagen, type IV, alpha 2 Col4a2 3653.5 3777.4 3692.7 3562.7 3605.2 3554.2 1.03744602270078 0.0282798017008684 0.053036276403951 Nonsignificant None 2 Molecular Function:extracellular matrix structural constituent (GO:0005201),Cellular Component:collagen trimer (GO:0005581) collagen, type IV, alpha -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04926 Relaxin signaling pathway ko04933 AGE-RAGE signaling pathway in diabetic complications ko04974 Protein digestion and absorption ko05146 Amoebiasis ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05222 Small cell lung cancer Collagens (type IV and type XIII), and related proteins W Extracellular structures ; IPR001442 [Collagen IV, non-collagenous] ; IPR008160[Collagen triple helix repeat] -- -- Q05D44 Eukaryotic translation initiation factor 5B Eif5b 3872.3 3751.9 4099.1 4155.8 4008.5 3870.4 0.974124822388593 0.472361108687279 -0.0378214467040391 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) translation initiation factor 5B -- ko03013 RNA transport Translation initiation factor 5B (eIF-5B) J Translation, ribosomal structure and biogenesis ; IPR004161 [Translation elongation factor EFTu-like, domain 2] ; IPR023115[Translation initiation factor IF- 2, domain 3] -- -- A0A679AXP3 GasderminD-1 Gsdmd 3772.2 3776.9 3748.5 3844 4044.6 3901.6 0.958219538260589 0.10746016374306 -0.0615718643180402 Nonsignificant None -- -- gasdermin-D -- ko04621 NOD-like receptor signaling pathway -- -- -- IPR007677 [Gasdermin] -- -- Q5BLK1 40S ribosomal protein S6 Rps6 11849.1 11506.9 10828.6 9535.9 9532.6 9575.4 1.19343385502672 0.0251589978540947 0.25511860859032 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S6e -- ko01521 EGFR tyrosine kinase inhibitor resistance ko03010 Ribosome ko04066 HIF-1 signaling pathway ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04371 Apelin signaling pathway ko04910 Insulin signaling pathway ko05205 Proteoglycans in cancer 40S ribosomal protein S6 J Translation, ribosomal structure and biogenesis ; IPR001377 [Ribosomal protein S6e] -- -- Q810K5 Y box protein 1 Ybx1 1914 1966.7 1681.5 1257.2 1308.6 1165.6 1.49064694216648 0.00327128461794586 0.575938597593976 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) Y-box-binding protein 1 -- -- Predicted RNA-binding protein containing PIN domain and invovled in translation or RNA processing J Translation, ribosomal structure and biogenesis ; IPR002059 [Cold-shock protein, DNA-binding] -- CSD P97449 Aminopeptidase N Anpep 1946.9 1844.1 1847.2 1914.6 2020.7 2251.6 0.911312612132085 0.15665664153173 -0.133982061048007 Nonsignificant None 2 Molecular Function:metallopeptidase activity (GO:0008237),Molecular Function:zinc ion binding (GO:0008270) aminopeptidase N 3.4.11.2 ko00480 Glutathione metabolism ko01100 Metabolic pathways ko04614 Renin-angiotensin system ko04640 Hematopoietic cell lineage Puromycin-sensitive aminopeptidase and related aminopeptidases EO Amino acid transport and metabolism ; Posttranslational modification, protein turnover, chaperones ; IPR014782 [Peptidase M1, membrane alanine aminopeptidase, N-terminal] ; IPR024571[ERAP1-like C-terminal domain] -- -- Q923G3 F-actin-capping protein subunit beta Capzb 8139.8 8394.4 7820.3 7117.8 7208.7 6986 1.14273313782991 0.00471289092024261 0.192488530691107 Nonsignificant None 2 Cellular Component:F-actin capping protein complex (GO:0008290),Biological Process:barbed-end actin filament capping (GO:0051016) capping protein (actin filament) muscle Z-line, beta -- ko04144 Endocytosis F-actin capping protein, beta subunit Z Cytoskeleton ; IPR001698 [F-actin-capping protein subunit beta] -- -- E9QB01 Neural cell adhesion molecule 1 Ncam1 462 748.8 572.6 598.2 609.8 595.2 0.989019520851819 0.944246099212607 -0.0159290983133097 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) neural cell adhesion molecule -- ko04514 Cell adhesion molecules (CAMs) ko05020 Prion diseases FOG: Immunoglobulin C-2 Type/fibronectin type III domains T Signal transduction mechanisms ; IPR003961 [Fibronectin type III] ; IPR013098[Immunoglobulin I-set] -- -- P67778 Prohibitin 1 Phb1 5489 5299.4 5643.7 6426.4 6426.1 6318.3 0.857142111961942 0.000994227159547316 -0.222393675583939 Nonsignificant None -- -- prohibitin 1 -- -- Prohibitin O Posttranslational modification, protein turnover, chaperones ; IPR001107 [Band 7 domain] -- -- Q58E56 Igh protein Igh 3119.5 3011.7 2372.5 1201 1216.1 1284.3 2.29742800021613 0.0195366902058629 1.20001964917099 Significant up -- -- -- -- -- -- -- -- IPR003597 [Immunoglobulin C1-set] ; IPR013106[Immunoglobulin V-set domain] -- -- A0A087WQS2 eIF5-mimic protein 2 Bzw1 6437.4 6386.2 6744.7 5069.3 5281.4 5360.5 1.24550002545954 0.000818754471662487 0.316725051069202 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Predicted translation factor, contains W2 domain J Translation, ribosomal structure and biogenesis ; IPR003307 [W2 domain] -- -- Q99JI4 26S proteasome non-ATPase regulatory subunit 6 Psmd6 6092 6297 5271.2 4830.9 4911 4893.1 1.20670994192005 0.0836574006267664 0.271078935709384 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) 26S proteasome regulatory subunit N7 -- ko03050 Proteasome ko05169 Epstein-Barr virus infection 26S proteasome regulatory complex, subunit RPN7/PSMD6 O Posttranslational modification, protein turnover, chaperones ; IPR000717 [Proteasome component (PCI) domain] ; IPR019585[26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1] -- -- B9EI85 Histone H3 Hist2h3b 1527 1913.4 2420 1534 1388.7 2219.9 1.13957920118228 0.546946494577589 0.188501195934629 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) histone H3 -- ko05034 Alcoholism ko05202 Transcriptional misregulation in cancer ko05322 Systemic lupus erythematosus Histones H3 and H4 B Chromatin structure and dynamics ; IPR007125 [Histone H2A/H2B/H3] -- -- D3YUW7 Cingulin Cgn 4186.7 3944.7 4564.8 4687.4 4810 4583.8 0.901641905519416 0.0739098634864149 -0.14937352582787 Nonsignificant None 2 Molecular Function:motor activity (GO:0003774),Cellular Component:myosin complex (GO:0016459) cingulin -- ko04530 Tight junction -- -- -- IPR002928 [Myosin tail] -- -- D3Z598 Latent-transforming growth factor beta-binding protein 4 Ltbp4 3213.8 3227.3 3391.6 3526.5 3623.9 3591.2 0.915385045058464 0.00903607879840403 -0.127549372531737 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) latent transforming growth factor beta binding protein 2/3/4 -- -- Fibrillins and related proteins containing Ca2+-binding EGF-like domains T Signal transduction mechanisms ; IPR001881 [EGF-like calcium-binding domain] ; IPR017878[TB domain] -- -- Q3TN31 Proteasome subunit alpha type Psma7 7829 7843.3 5666.8 5139.1 5227.9 5568.4 1.33910036773473 0.070362381717083 0.421264097037522 Nonsignificant None 5 Molecular Function:endopeptidase activity (GO:0004175),Molecular Function:threonine-type endopeptidase activity (GO:0004298),Cellular Component:proteasome core complex (GO:0005839),Biological Process:ubiquitin-dependent protein catabolic process (GO:0006511),Biological Process:proteolysis involved in cellular protein catabolic process (GO:0051603) 20S proteasome subunit alpha 4 3.4.25.1 ko03050 Proteasome 20S proteasome, regulatory subunit alpha type PSMA7/PRE6 O Posttranslational modification, protein turnover, chaperones ; IPR000426 [Proteasome alpha-subunit, N-terminal domain] ; IPR001353[Proteasome, subunit alpha/beta] -- -- Q9D281 Protein Noxp20 Fam114a1 2857.1 2947.3 2625.3 2878.9 2765.6 2681.4 1.01246712067164 0.772162474426919 0.0178750580079525 Nonsignificant None -- -- -- -- -- -- -- -- IPR007998 [Protein of unknown function DUF719] -- -- P01901 H-2 class I histocompatibility antigen, K-B alpha chain H2-K1 2166.8 2154 2304.1 2752.5 3030 2802.2 0.771710135473575 0.00263262701630093 -0.373869040973135 Nonsignificant None 2 Biological Process:immune response (GO:0006955),Biological Process:antigen processing and presentation (GO:0019882) major histocompatibility complex, class I -- ko04144 Endocytosis ko04145 Phagosome ko04218 Cellular senescence ko04514 Cell adhesion molecules (CAMs) ko04612 Antigen processing and presentation ko04940 Type I diabetes mellitus ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis ko05320 Autoimmune thyroid disease ko05330 Allograft rejection ko05332 Graft-versus-host disease ko05416 Viral myocarditis -- -- -- IPR003597 [Immunoglobulin C1-set] ; IPR010579[MHC class I, alpha chain, C-terminal] ; IPR011161[MHC class I-like antigen recognition-like] -- -- Q62159 Rho-related GTP-binding protein RhoC Rhoc 521.8 483.8 564.3 663.7 634.8 645.9 0.80739559761366 0.00723903435999545 -0.30865237445271 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras homolog gene family, member C -- -- Ras-related small GTPase, Rho type R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- Q4FJQ0 Rab7 Rab7 5398.3 5544.5 5468.7 5199.3 5253.1 5116.6 1.05411394437665 0.00836150501852293 0.0760308234287365 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-7A -- ko04137 Mitophagy - animal ko04140 Autophagy - animal ko04144 Endocytosis ko04145 Phagosome ko05132 Salmonella infection ko05146 Amoebiasis ko05152 Tuberculosis Ras-related GTPase R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- P42227 Signal transducer and activator of transcription 3 Stat3 3499.2 3572.3 3507.8 3471.8 3543.7 3409.3 1.01482042820965 0.31781166819659 0.0212244660794578 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Biological Process:signal transduction (GO:0007165) signal transducer and activator of transcription 3 -- ko01521 EGFR tyrosine kinase inhibitor resistance ko04062 Chemokine signaling pathway ko04066 HIF-1 signaling pathway ko04068 FoxO signaling pathway ko04217 Necroptosis ko04550 Signaling pathways regulating pluripotency of stem cells ko04630 Jak-STAT signaling pathway ko04659 Th17 cell differentiation ko04917 Prolactin signaling pathway ko04920 Adipocytokine signaling pathway ko04931 Insulin resistance ko04933 AGE-RAGE signaling pathway in diabetic complications ko05145 Toxoplasmosis ko05160 Hepatitis C ko05161 Hepatitis B ko05162 Measles ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05205 Proteoglycans in cancer ko05206 MicroRNAs in cancer ko05212 Pancreatic cancer ko05221 Acute myeloid leukemia ko05223 Non-small cell lung cancer ko05321 Inflammatory bowel disease (IBD) STAT protein KT Transcription ; Signal transduction mechanisms ; IPR000980 [SH2 domain] ; IPR013799[STAT transcription factor, protein interaction] ; IPR013800[STAT transcription factor, all-alpha domain] ; IPR013801[STAT transcription factor, DNA-binding] -- STAT Q9D051 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial Pdhb 4085.6 4046.7 4628 5175.7 5097.8 5254.9 0.821739522423431 0.00877387363799798 -0.283246938524429 Nonsignificant None -- -- pyruvate dehydrogenase E1 component beta subunit 1.2.4.1 ko00010 Glycolysis / Gluconeogenesis ko00020 Citrate cycle (TCA cycle) ko00620 Pyruvate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko04066 HIF-1 signaling pathway ko04922 Glucagon signaling pathway ko05230 Central carbon metabolism in cancer Pyruvate dehydrogenase E1, beta subunit C Energy production and conversion ; IPR005475 [Transketolase-like, pyrimidine-binding domain] ; IPR033248[Transketolase, C-terminal domain] -- -- Q5BLK0 60S ribosomal protein L12 Rpl12 202.9 285.8 308.8 292.7 292.9 293.4 0.907281001137657 0.487194320227989 -0.140378646491172 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L12e -- ko03010 Ribosome 40S ribosomal protein S2 J Translation, ribosomal structure and biogenesis ; IPR020783 [Ribosomal protein L11, C-terminal] ; IPR020784[Ribosomal protein L11, N-terminal] -- -- O35459 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial Ech1 3691 3664.4 5522.3 3716.8 3429.8 3729.9 1.18399301245805 0.391519256945903 0.243660566674748 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase 5.3.3.- ko04146 Peroxisome Enoyl-CoA isomerase I Lipid transport and metabolism ; IPR001753 [Crotonase superfamily] -- -- P45377 Aldose reductase-related protein 2 Akr1b8 2998.6 2951.7 1932.3 2126 1939.6 1974.3 1.30508783258001 0.156430714534058 0.384146903625446 Nonsignificant None -- -- aldehyde reductase 1.1.1.21 ko00040 Pentose and glucuronate interconversions ko00051 Fructose and mannose metabolism ko00052 Galactose metabolism ko00561 Glycerolipid metabolism ko00790 Folate biosynthesis ko01100 Metabolic pathways Aldo/keto reductase family proteins R General function prediction only ; IPR023210 [NADP-dependent oxidoreductase domain] -- -- Q8BJD1 Inter-alpha-trypsin inhibitor heavy chain H5 Itih5 3694.1 3751.7 3766.9 3902 4294.8 3848.7 0.930862147690009 0.184498281911006 -0.103360561442022 Nonsignificant None 2 Molecular Function:serine-type endopeptidase inhibitor activity (GO:0004867),Biological Process:hyaluronan metabolic process (GO:0030212) -- -- -- -- -- -- IPR002035 [von Willebrand factor, type A] ; IPR010600[Inter-alpha-trypsin inhibitor heavy chain, C-terminal] ; IPR013694[VIT domain] -- -- Q00519 Xanthine dehydrogenase/oxidase Xdh 3930.5 4047.4 3569.1 3392.4 3773.5 3551.2 1.07743699321645 0.202137135852617 0.107603505294001 Nonsignificant None 5 Molecular Function:electron carrier activity (GO:0009055),Molecular Function:oxidoreductase activity (GO:0016491),Molecular Function:metal ion binding (GO:0046872),Molecular Function:iron-sulfur cluster binding (GO:0051536),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00230 Purine metabolism ko00232 Caffeine metabolism ko00983 Drug metabolism - other enzymes ko01100 Metabolic pathways ko04146 Peroxisome Xanthine dehydrogenase F Nucleotide transport and metabolism ; IPR000674 [Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead] ; IPR001041[2Fe-2S ferredoxin-type iron-sulfur binding domain] ; IPR002346[Molybdopterin dehydrogenase, FAD-binding] ; IPR002888[[2Fe-2S]-binding] ; IPR005107[CO dehydrogenase flavoprotein, C-terminal] ; IPR008274[Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding] -- -- Q3U292 H15 domain-containing protein H1f3 50.1 56.4 67 39.7 39.6 62.1 1.22701555869873 0.298464165251015 0.295153542656224 Nonsignificant None 4 Cellular Component:nucleosome (GO:0000786),Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634),Biological Process:nucleosome assembly (GO:0006334) histone H1/5 -- -- Histone H1 B Chromatin structure and dynamics ; IPR005818 [Linker histone H1/H5, domain H15] -- -- Q58ET1 60S ribosomal protein L7a Rpl7a 8690.5 8971.8 7610.4 6522.4 6580.1 6300.3 1.30252850104109 0.00988933777174634 0.381314940918963 Nonsignificant None -- -- large subunit ribosomal protein L7Ae -- ko03010 Ribosome 60S ribosomal protein L7A J Translation, ribosomal structure and biogenesis ; IPR004038 [Ribosomal protein L7Ae/L30e/S12e/Gadd45] -- -- Q3B7Z2 Oxysterol-binding protein 1 Osbp 3845.5 3699.4 4049 4056.1 4023.6 4185.9 0.945237085833551 0.118247216368573 -0.0812518611547957 Nonsignificant None -- -- oxysterol-binding protein 1 -- -- Oxysterol-binding protein I Lipid transport and metabolism ; IPR000648 [Oxysterol-binding protein] ; IPR001849[Pleckstrin homology domain] -- -- P53810 Phosphatidylinositol transfer protein alpha isoform Pitpna 4592.4 4540.1 5354.7 5024.5 4961.8 5129.7 0.958401693569727 0.477512081339655 -0.0612976374049789 Nonsignificant None 2 Cellular Component:intracellular (GO:0005622),Biological Process:transport (GO:0006810) -- -- -- Phosphatidylinositol transfer protein IT Lipid transport and metabolism ; Signal transduction mechanisms ; IPR001666 [Phosphatidylinositol transfer protein] -- -- Q3U7P0 Cathepsin D Ctsd 4650.6 4705.3 4234 4411.5 4716 4386 1.00565360565361 0.895887912288738 0.00813345875868517 Nonsignificant None 2 Molecular Function:aspartic-type endopeptidase activity (GO:0004190),Biological Process:proteolysis (GO:0006508) cathepsin D 3.4.23.5 ko04071 Sphingolipid signaling pathway ko04140 Autophagy - animal ko04142 Lysosome ko04210 Apoptosis ko05152 Tuberculosis Aspartyl protease O Posttranslational modification, protein turnover, chaperones ; IPR012848 [Aspartic peptidase, N-terminal] ; IPR033121[Peptidase family A1 domain] -- -- Q3T9L1 Coronin Coro1a 6948.2 8542.7 6307.2 4685.6 5036 4861 1.49480202433037 0.0654764959957323 0.579954422597286 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) coronin-1A -- ko04145 Phagosome ko05152 Tuberculosis Actin-binding protein Coronin, contains WD40 repeats Z Cytoskeleton ; IPR001680 [WD40 repeat] ; IPR015048[Domain of unknown function DUF1899] ; IPR015049[Trimerisation motif] -- -- Q6ZQ08 CCR4-NOT transcription complex subunit 1 Cnot1 2613.3 2611 2662.4 2448.4 2610.1 2618.5 1.02731535756155 0.29337693385337 0.0388791173446823 Nonsignificant None -- -- CCR4-NOT transcription complex subunit 1 -- ko03018 RNA degradation Negative regulator of transcription K Transcription ; IPR007196 [CCR4-Not complex component, Not1, C-terminal] ; IPR024557[CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819] ; IPR032191[CCR4-NOT transcription complex subunit 1, CAF1-binding domain] ; IPR032193[CCR4-NOT transcription complex subunit 1, TTP binding domain] ; IPR032194[CCR4-NOT transcription complex subunit 1, HEAT repeat] -- -- Q9D1G1 Ras-related protein Rab-1B Rab1b 1377.8 1363 1388.9 1494.7 1456.6 1424.8 0.943694156897694 0.0189290516596682 -0.0836087245163725 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-1B -- ko05134 Legionellosis GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- Q3UMR5 Calcium uniporter protein, mitochondrial Mcu 5383.5 4940.5 5450.6 5878.3 5660.3 5982.3 0.900330462476243 0.0352211441646973 -0.151473461145907 Nonsignificant None -- -- calcium uniporter protein, mitochondrial -- ko04020 Calcium signaling pathway ko04218 Cellular senescence ko04621 NOD-like receptor signaling pathway Uncharacterized conserved protein R General function prediction only ; IPR006769 [Coiled-coil domain containing protein 109, C-terminal] -- -- P11247 Myeloperoxidase Mpo 3402.2 5909.2 3618 1589.5 1656.8 1571.1 2.68389587744426 0.077705487025397 1.42432870283146 Nonsignificant None -- -- myeloperoxidase 1.11.2.2 ko04145 Phagosome ko05202 Transcriptional misregulation in cancer ko05221 Acute myeloid leukemia Peroxidase/oxygenase R General function prediction only ; IPR019791 [Haem peroxidase, animal] -- -- Q3TMJ8 Mitogen activated protein kinase kinase 1 Map2k1 2973 2967.2 3388 3764.6 3866.1 3777.8 0.817653503966341 0.00832535467631451 -0.290438491345006 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) mitogen-activated protein kinase kinase 1 2.7.12.2 ko01521 EGFR tyrosine kinase inhibitor resistance ko01522 Endocrine resistance ko04010 MAPK signaling pathway ko04012 ErbB signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04062 Chemokine signaling pathway ko04066 HIF-1 signaling pathway ko04068 FoxO signaling pathway ko04071 Sphingolipid signaling pathway ko04072 Phospholipase D signaling pathway ko04114 Oocyte meiosis ko04140 Autophagy - animal ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04210 Apoptosis ko04218 Cellular senescence ko04270 Vascular smooth muscle contraction ko04370 VEGF signaling pathway ko04371 Apelin signaling pathway ko04380 Osteoclast differentiation ko04510 Focal adhesion ko04540 Gap junction ko04550 Signaling pathways regulating pluripotency of stem cells ko04620 Toll-like receptor signaling pathway ko04650 Natural killer cell mediated cytotoxicity ko04660 T cell receptor signaling pathway ko04662 B cell receptor signaling pathway ko04664 Fc epsilon RI signaling pathway ko04666 Fc gamma R-mediated phagocytosis ko04668 TNF signaling pathway ko04720 Long-term potentiation ko04722 Neurotrophin signaling pathway ko04725 Cholinergic synapse ko04726 Serotonergic synapse ko04730 Long-term depression ko04810 Regulation of actin cytoskeleton ko04910 Insulin signaling pathway ko04912 GnRH signaling pathway ko04914 Progesterone-mediated oocyte maturation ko04915 Estrogen signaling pathway ko04916 Melanogenesis ko04917 Prolactin signaling pathway ko04919 Thyroid hormone signaling pathway ko04921 Oxytocin signaling pathway ko04926 Relaxin signaling pathway ko05020 Prion diseases ko05034 Alcoholism ko05161 Hepatitis B ko05164 Influenza A ko05165 Human papillomavirus infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05206 MicroRNAs in cancer ko05210 Colorectal cancer ko05211 Renal cell carcinoma ko05212 Pancreatic cancer ko05213 Endometrial cancer ko05214 Glioma ko05215 Prostate cancer ko05216 Thyroid cancer ko05218 Melanoma ko05219 Bladder cancer ko05220 Chronic myeloid leukemia ko05221 Acute myeloid leukemia ko05223 Non-small cell lung cancer ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer ko05230 Central carbon metabolism in cancer ko05231 Choline metabolism in cancer Mitogen-activated protein kinase kinase (MAP2K) T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q8CI51 PDZ and LIM domain protein 5 Pdlim5 3189.3 3164.6 3131.1 3130.3 3178.8 3058.3 1.01255417725303 0.370115944032268 0.0179991022325247 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:zinc ion binding (GO:0008270) -- -- -- Adaptor protein Enigma and related PDZ-LIM proteins TZ Signal transduction mechanisms ; Cytoskeleton ; IPR001478 [PDZ domain] ; IPR001781[Zinc finger, LIM-type] ; IPR031847[Domain of unknown function DUF4749] -- -- Q9WVJ2 26S proteasome non-ATPase regulatory subunit 13 Psmd13 5710.4 5688.9 5378.6 4531.5 4804.1 4777.9 1.18878378857123 0.00299452023232603 0.249486347110135 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) 26S proteasome regulatory subunit N9 -- ko03050 Proteasome ko05169 Epstein-Barr virus infection 26S proteasome regulatory complex, subunit RPN9/PSMD13 O Posttranslational modification, protein turnover, chaperones ; IPR000717 [Proteasome component (PCI) domain] -- -- P23953 Carboxylesterase 1C Ces1c 3364.1 3237.6 3398.2 3198.4 3488.9 3378.1 0.993492558666322 0.834164150219639 -0.00941893326586384 Nonsignificant None -- -- carboxylesterase 1 3.1.1.1 ko00983 Drug metabolism - other enzymes ko01100 Metabolic pathways Carboxylesterase and related proteins R General function prediction only ; IPR002018 [Carboxylesterase, type B] -- -- Q9DBX5 Phospholipase A2 Pla2g4a 3239.4 3187.8 3194.6 3123.3 3235.1 3103.9 1.01685636684527 0.293209431268544 0.0241159098007221 Nonsignificant None 3 Molecular Function:phospholipase activity (GO:0004620),Molecular Function:protein binding (GO:0005515),Biological Process:phospholipid catabolic process (GO:0009395) cytosolic phospholipase A2 3.1.1.4 ko00564 Glycerophospholipid metabolism ko00565 Ether lipid metabolism ko00590 Arachidonic acid metabolism ko00591 Linoleic acid metabolism ko00592 alpha-Linolenic acid metabolism ko01100 Metabolic pathways ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04072 Phospholipase D signaling pathway ko04217 Necroptosis ko04270 Vascular smooth muscle contraction ko04370 VEGF signaling pathway ko04611 Platelet activation ko04664 Fc epsilon RI signaling pathway ko04724 Glutamatergic synapse ko04726 Serotonergic synapse ko04730 Long-term depression ko04750 Inflammatory mediator regulation of TRP channels ko04912 GnRH signaling pathway ko04913 Ovarian steroidogenesis ko04921 Oxytocin signaling pathway ko05231 Choline metabolism in cancer Lysophospholipase I Lipid transport and metabolism ; IPR000008 [C2 domain] ; IPR002642[Lysophospholipase, catalytic domain] -- -- P13595 Neural cell adhesion molecule 1 Ncam1 289.1 278.9 358.6 384.9 405.7 401.2 0.77747944285954 0.0267062926148814 -0.363123565080364 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) neural cell adhesion molecule -- ko04514 Cell adhesion molecules (CAMs) ko05020 Prion diseases FOG: Immunoglobulin C-2 Type/fibronectin type III domains T Signal transduction mechanisms ; IPR003961 [Fibronectin type III] ; IPR013098[Immunoglobulin I-set] -- -- Q8CGB9 Insulin-degrading enzyme Ide 6133.6 6012.7 5460.2 4972.8 4875.3 5113.6 1.17677135619615 0.0156744193787205 0.234834035477735 Nonsignificant None -- -- insulysin 3.4.24.56 ko05010 Alzheimer's disease N-arginine dibasic convertase NRD1 and related Zn2+-dependent endopeptidases, insulinase superfamily O Posttranslational modification, protein turnover, chaperones ; IPR007863 [Peptidase M16, C-terminal] ; IPR011765[Peptidase M16, N-terminal] ; IPR032632[Peptidase M16, middle/third domain] -- -- P51660 Peroxisomal multifunctional enzyme type 2 Hsd17b4 4554.4 4722.1 5396.2 5059.9 5151.9 5074.4 0.959865761274875 0.510538711503116 -0.0590954381000431 Nonsignificant None -- -- -- -- ko00120 Primary bile acid biosynthesis ko01100 Metabolic pathways ko04146 Peroxisome -- -- -- IPR002347 [Short-chain dehydrogenase/reductase SDR] ; IPR002539[MaoC-like domain] ; IPR003033[SCP2 sterol-binding domain] -- -- Q60737 Casein kinase II subunit alpha Csnk2a1 4683.8 4521 4921.4 4858.2 5005.6 4962.7 0.952767005024787 0.133413026235275 -0.0698046423395593 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) casein kinase II subunit alpha 2.7.11.1 ko03008 Ribosome biogenesis in eukaryotes ko04064 NF-kappa B signaling pathway ko04137 Mitophagy - animal ko04310 Wnt signaling pathway ko04520 Adherens junction ko05162 Measles ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection Casein kinase II, alpha subunit TDK Signal transduction mechanisms ; Cell cycle control, cell division, chromosome partitioning ; Transcription ; IPR000719 [Protein kinase domain] -- -- P07310 Creatine kinase M-type Ckm 3212.8 3468.5 4514.8 4843.9 4109.5 3809.2 0.877258552332597 0.357912696317793 -0.188925987457775 Nonsignificant None 1 Molecular Function:kinase activity (GO:0016301) creatine kinase 2.7.3.2 ko00330 Arginine and proline metabolism ko01100 Metabolic pathways Creatine kinases C Energy production and conversion ; IPR022413 [ATP:guanido phosphotransferase, N-terminal] ; IPR022414[ATP:guanido phosphotransferase, catalytic domain] -- -- O54774 AP-3 complex subunit delta-1 Ap3d1 2588.2 2565.9 2949.8 3163.4 3107.8 3130.9 0.861924463683645 0.0713212533275905 -0.214366653234267 Nonsignificant None 5 Biological Process:intracellular protein transport (GO:0006886),Biological Process:protein transport (GO:0015031),Biological Process:vesicle-mediated transport (GO:0016192),Cellular Component:membrane coat (GO:0030117),Cellular Component:AP-3 adaptor complex (GO:0030123) AP-3 complex subunit delta -- ko04142 Lysosome Vesicle coat complex AP-3, delta subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR002553 [Clathrin/coatomer adaptor, adaptin-like, N-terminal] ; IPR010474[AP-3 complex subunit delta-1] -- -- O70194 Eukaryotic translation initiation factor 3 subunit D Eif3d 3407.3 3590.5 3475.9 3038.9 3033.5 2905.3 1.16663510698731 0.00194522621987804 0.222353394243243 Nonsignificant None 3 Molecular Function:translation initiation factor activity (GO:0003743),Cellular Component:cytoplasm (GO:0005737),Cellular Component:eukaryotic translation initiation factor 3 complex (GO:0005852) translation initiation factor 3 subunit D -- ko03013 RNA transport Translation initiation factor 3, subunit d (eIF-3d) J Translation, ribosomal structure and biogenesis ; IPR007783 [Eukaryotic translation initiation factor 3 subunit D] -- -- A0A1Y7VJW9 Fibulin-5 Fbln5 3913.7 3643.3 3723.5 3935.4 4199.7 4610 0.885085248448423 0.0826835970242603 -0.176111677442325 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) fibulin 5 -- -- Fibrillins and related proteins containing Ca2+-binding EGF-like domains T Signal transduction mechanisms ; IPR001881 [EGF-like calcium-binding domain] ; IPR013032[EGF-like, conserved site] ; IPR026823[Complement Clr-like EGF domain] -- -- Q8VD79 H-caldesmon (Fragment) Cald1 712.7 875.2 677 124.8 145 638.4 2.49383395727813 0.0645864325675892 1.31836541184522 Nonsignificant None -- -- caldesmon -- ko04270 Vascular smooth muscle contraction -- -- -- -- -- -- Q8CIN4 Serine/threonine-protein kinase PAK 2 Pak2 4101.8 4039.1 4407.1 3990.8 3983.3 3960.8 1.05137035081986 0.213386601820241 0.0722709558600935 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) p21-activated kinase 2 2.7.11.1 ko04010 MAPK signaling pathway ko04012 ErbB signaling pathway ko04014 Ras signaling pathway ko04360 Axon guidance ko04510 Focal adhesion ko04660 T cell receptor signaling pathway ko04810 Regulation of actin cytoskeleton ko05211 Renal cell carcinoma p21-activated serine/threonine protein kinase T Signal transduction mechanisms ; IPR000095 [CRIB domain] ; IPR000719[Protein kinase domain] -- -- B1AU76 Nuclear autoantigenic sperm protein Nasp 4800.2 4663.1 4082.8 3594.1 3610.9 3695 1.24276146788991 0.0542786227659338 0.313549416168523 Nonsignificant None -- -- nuclear autoantigenic sperm protein -- -- Cell cycle-regulated histone H1-binding protein BD Chromatin structure and dynamics ; Cell cycle control, cell division, chromosome partitioning ; IPR019544 [Tetratricopeptide, SHNi-TPR domain] -- -- P15864 Histone H1.2 H1-2 426.2 270.7 379.2 525.9 446.4 508.8 0.72655458780636 0.0602848456084601 -0.460856899783572 Nonsignificant None 4 Cellular Component:nucleosome (GO:0000786),Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634),Biological Process:nucleosome assembly (GO:0006334) histone H1/5 -- -- Histone H1 B Chromatin structure and dynamics ; IPR005818 [Linker histone H1/H5, domain H15] -- -- Q61635 GTP-binding protein Ifi47 2558.5 2997.7 2620.1 1951.8 2101.9 2005.8 1.34933575377506 0.00807080062653382 0.432249377223233 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Cellular Component:membrane (GO:0016020) interferon gamma inducible protein 47 -- ko04668 TNF signaling pathway -- -- -- IPR007743 [Immunity-related GTPases-like] -- -- A0A0R4J005 LIM and senescent cell antigen-like-containing domain protein Lims1 1938.8 2123.1 2320.6 2447 2369.8 2331 0.892932090993033 0.0915472859670296 -0.163377634784937 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) -- -- -- Focal adhesion protein PINCH-1, contains LIM domains TZ Signal transduction mechanisms ; Cytoskeleton ; IPR001781 [Zinc finger, LIM-type] -- -- Q8BJ71 Nuclear pore complex protein Nup93 Nup93 3793.4 3605.1 3746 3587.2 3582 3601.9 1.03466683996992 0.157279930955876 0.0491662984505234 Nonsignificant None 2 Cellular Component:nuclear pore (GO:0005643),Biological Process:transport (GO:0006810) nuclear pore complex protein Nup93 -- ko03013 RNA transport Cullins D Cell cycle control, cell division, chromosome partitioning ; IPR007231 [Nucleoporin interacting component Nup93/Nic96] -- -- Q8C7F9 Transmembrane 9 superfamily member Tm9sf2 5075.5 5009.6 5112.6 5183.6 5182.8 5337.6 0.967759806418747 0.0473388860923605 -0.0472790733049196 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) transmembrane 9 superfamily member 2/4 -- -- Endosomal membrane proteins, EMP70 U Intracellular trafficking, secretion, and vesicular transport ; IPR004240 [Nonaspanin (TM9SF)] -- -- Q8C1B7 Septin-11 Septin11 1975.4 2184.5 2307.9 2057 2112.2 2015.9 1.04570661751629 0.40351764629333 0.0644781471644884 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) septin 6/8/11 -- ko05100 Bacterial invasion of epithelial cells Septins (P-loop GTPases) D Cell cycle control, cell division, chromosome partitioning ; IPR030379 [Septin-type guanine nucleotide-binding (G) domain] -- -- P07759 Serine protease inhibitor A3K Serpina3k 1185.9 1213.8 1048.5 855.6 1286 966.8 1.10931669025865 0.460103281961356 0.149671288171231 Nonsignificant None -- -- serpin peptidase inhibitor, clade A -- -- Serpin V Defense mechanisms ; IPR023796 [Serpin domain] -- -- P97496 SWI/SNF complex subunit SMARCC1 Smarcc1 2539.7 2637.4 2601.1 2125 2221.3 2166.4 1.19431265066716 0.000452245658395599 0.256180558982985 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) SWI/SNF related-matrix-associated actin-dependent regulator of chromatin subfamily C -- ko05225 Hepatocellular carcinoma Chromatin remodeling factor subunit and related transcription factors B Chromatin structure and dynamics ; IPR001005 [SANT/Myb domain] ; IPR007526[SWIRM domain] ; IPR032448[SMARCC, SWIRM-associated domain] ; IPR032450[SMARCC, N-terminal] ; IPR032451[SMARCC, C-terminal] -- MYB Q5SVP3 PA28 beta subunit PSME2b 4142.1 4298.4 4634.3 4542.1 4779.1 4545.6 0.942885164565725 0.184910578774797 -0.0848460213357626 Nonsignificant None 1 Cellular Component:proteasome activator complex (GO:0008537) proteasome activator subunit 2 (PA28 beta) -- ko03050 Proteasome ko04612 Antigen processing and presentation Proteasome activator subunit O Posttranslational modification, protein turnover, chaperones ; IPR003185 [Proteasome activator pa28, N-terminal domain] ; IPR003186[Proteasome activator pa28, C-terminal domain] -- -- P47963 60S ribosomal protein L13 Rpl13 10310.1 10639.9 9308.4 8007.2 8031.7 7591.1 1.28050782903089 0.006527775865025 0.356716073606616 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L13e -- ko03010 Ribosome 60S Ribosomal protein L13 J Translation, ribosomal structure and biogenesis ; IPR001380 [Ribosomal protein L13e] -- -- P28352 DNA-(apurinic or apyrimidinic site) endonuclease Apex1 2568.6 2651.6 3145.7 3125.2 3040.5 3296.2 0.88416702776398 0.134586560695583 -0.177609160378632 Nonsignificant None -- -- AP endonuclease 1 4.2.99.18 ko03410 Base excision repair Apurinic/apyrimidinic endonuclease and related enzymes L Replication, recombination and repair ; IPR005135 [Endonuclease/exonuclease/phosphatase] -- -- Q3U094 Actin-related protein 2/3 complex subunit Arpc1b 7693.6 7672.9 6114.4 6315.7 6474.5 6045.2 1.14045361393971 0.176403003010481 0.189607768614033 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) actin related protein 2/3 complex, subunit 1A/1B -- ko04144 Endocytosis ko04666 Fc gamma R-mediated phagocytosis ko04810 Regulation of actin cytoskeleton ko05100 Bacterial invasion of epithelial cells ko05132 Salmonella infection Actin-related protein Arp2/3 complex, subunit ARPC1/p41-ARC Z Cytoskeleton ; IPR001680 [WD40 repeat] -- -- Q9QZD9 Eukaryotic translation initiation factor 3 subunit I Eif3i 6281.1 6246.8 5959.4 5163.3 5147.3 5316.7 1.1830130604775 0.00117182031883334 0.242466001135104 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) translation initiation factor 3 subunit I -- ko03013 RNA transport Translation initiation factor 3, subunit i (eIF-3i)/TGF-beta receptor-interacting protein (TRIP-1) JT Translation, ribosomal structure and biogenesis ; Signal transduction mechanisms ; IPR001680 [WD40 repeat] -- -- P27612 Phospholipase A-2-activating protein Plaa 3559.4 3469.9 3105.8 2845.1 2870.3 2825.2 1.18669648502447 0.060650709197539 0.246950991810228 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) phospholipase A-2-activating protein -- ko04141 Protein processing in endoplasmic reticulum Phospholipase A2-activating protein (contains WD40 repeats) I Lipid transport and metabolism ; IPR001680 [WD40 repeat] ; IPR013535[PUL domain] ; IPR015155[PLAA family ubiquitin binding, PFU] -- -- O70251 Elongation factor 1-beta Eef1b 8687.4 8944.3 7241.7 6369.8 6922.2 6461.8 1.25917038746975 0.0374790461723368 0.332473517787065 Nonsignificant None 2 Molecular Function:translation elongation factor activity (GO:0003746),Biological Process:translational elongation (GO:0006414) elongation factor 1-beta -- -- Elongation factor 1 beta/delta chain K Transcription ; IPR014038 [Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain] ; IPR018940[Elongation factor 1 beta central acidic region, eukaryote] -- -- Q91V76 Ester hydrolase C11orf54 homolog 2460.7 2606.1 4181.8 3885.9 3391.2 3721.2 0.84091177727467 0.364001634330028 -0.249973644186597 Nonsignificant None 1 Cellular Component:nucleus (GO:0005634) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR015021 [Domain of unknown function DUF1907] -- -- P05063 Fructose-bisphosphate aldolase C Aldoc 1593.3 1438.2 1534 1680.7 1787.8 1876.9 0.854098851348823 0.0230652036097156 -0.227525041320743 Nonsignificant None 2 Molecular Function:fructose-bisphosphate aldolase activity (GO:0004332),Biological Process:glycolytic process (GO:0006096) fructose-bisphosphate aldolase, class I 4.1.2.13 ko00010 Glycolysis / Gluconeogenesis ko00030 Pentose phosphate pathway ko00051 Fructose and mannose metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids Fructose-biphosphate aldolase G Carbohydrate transport and metabolism ; IPR000741 [Fructose-bisphosphate aldolase, class-I] -- -- Q6A0C9 AP-2 complex subunit mu (Fragment) Ap2m1 4590.1 4425.2 4374.6 4280 4226.7 4385.5 1.03860473774841 0.106972843559455 0.0546467116191667 Nonsignificant None -- -- AP-2 complex subunit mu-1 -- ko04144 Endocytosis ko04721 Synaptic vesicle cycle ko04961 Endocrine and other factor-regulated calcium reabsorption ko05016 Huntington's disease Adaptor complexes medium subunit family U Intracellular trafficking, secretion, and vesicular transport ; IPR022775 [AP complex, mu/sigma subunit] ; IPR028565[Mu homology domain] -- -- P28474 Alcohol dehydrogenase class-3 Adh5 6302.1 5934.7 6915.8 6618.3 6124.5 6651.2 0.987552851397339 0.820961987121818 -0.0180701351573537 Nonsignificant None 1 Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00010 Glycolysis / Gluconeogenesis ko00071 Fatty acid degradation ko00350 Tyrosine metabolism ko00830 Retinol metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko01100 Metabolic pathways ko01200 Carbon metabolism ko05204 Chemical carcinogenesis Alcohol dehydrogenase, class III Q Secondary metabolites biosynthesis, transport and catabolism ; IPR013149 [Alcohol dehydrogenase, C-terminal] ; IPR013154[Alcohol dehydrogenase, N-terminal] -- -- Q91YI0 Argininosuccinate lyase Asl 3546.4 3326.4 3700.4 3859.5 3881.5 4089.3 0.893738958437233 0.0328703211201683 -0.162074581556522 Nonsignificant None -- -- argininosuccinate lyase 4.3.2.1 ko00220 Arginine biosynthesis ko00250 Alanine, aspartate and glutamate metabolism ko01100 Metabolic pathways ko01230 Biosynthesis of amino acids Argininosuccinate lyase E Amino acid transport and metabolism ; IPR022761 [Fumarate lyase, N-terminal] ; IPR029419[Argininosuccinate lyase, C-terminal] -- -- O89079 Coatomer subunit epsilon Cope 2727.7 2757 2954.4 3013.6 3009.9 2946.3 0.940834801221878 0.0763483618606352 -0.0879866688312538 Nonsignificant None -- -- coatomer subunit epsilon -- -- Vesicle coat complex COPI, epsilon subunit U Intracellular trafficking, secretion, and vesicular transport ; -- -- -- Q3V0B5 WH2 domain-containing protein Lmod1 5317.9 5734.5 5836.6 6189.5 5772.9 5910.9 0.944929028215271 0.177010755734549 -0.0817221195081035 Nonsignificant None 3 Molecular Function:actin binding (GO:0003779),Molecular Function:tropomyosin binding (GO:0005523),Biological Process:pointed-end actin filament capping (GO:0051694) leiomodin -- -- Tropomodulin and leiomodulin Z Cytoskeleton ; IPR003124 [WH2 domain] ; IPR004934[Tropomodulin] -- -- Q3TFH8 Phosphoacetylglucosamine mutase Pgm3 2908.1 2892.3 3320.9 3621.6 3462.6 3655.5 0.849306777656732 0.0240110261174265 -0.235642331849734 Nonsignificant None 2 Biological Process:carbohydrate metabolic process (GO:0005975),Biological Process:organic substance metabolic process (GO:0071704) phosphoacetylglucosamine mutase 5.4.2.3 ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways Phosphoglucomutase/phosphomannomutase G Carbohydrate transport and metabolism ; IPR005843 [Alpha-D-phosphohexomutase, C-terminal] ; IPR005844[Alpha-D-phosphohexomutase, alpha/beta/alpha domain I] -- -- Q99LX0 Parkinson disease protein 7 homolog Park7 6179.1 6061.8 6549.9 7170.1 6892.4 7412.6 0.875004074486265 0.0131074427351292 -0.192638359968175 Nonsignificant None -- -- protein DJ-1 3.5.1.124 ko05012 Parkinson's disease Putative transcriptional regulator DJ-1 RV General function prediction only ; Defense mechanisms ; IPR002818 [DJ-1/PfpI] -- -- Q9CZ30 Obg-like ATPase 1 Ola1 6614.9 7031.6 6181.7 5891.7 5905.6 5788.6 1.12750555843033 0.0898265913493429 0.173134545764568 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) obg-like ATPase 1 -- -- Predicted GTP-binding protein (ODN superfamily) R General function prediction only ; IPR006073 [GTP binding domain] ; IPR013029[Domain of unknown function DUF933] -- -- Q3UJR8 Transcription factor BTF3 Btf3 3122.7 3034.9 3285.5 2521.1 2617.6 2627.3 1.21595415915529 0.00229677529315235 0.282088840947674 Nonsignificant None -- -- nascent polypeptide-associated complex subunit beta -- RNA polymerase II general transcription factor BTF3 and related proteins K Transcription ; IPR002715 [Nascent polypeptide-associated complex NAC domain] -- -- A1L2Z3 ER membrane protein complex subunit 1 Emc1 2559.6 2427.3 2396.4 2438.3 2576 2537.8 0.977648601051363 0.433740659427681 -0.0326120884204371 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR002372 [Pyrrolo-quinoline quinone repeat] ; IPR011678[Domain of unknown function DUF1620] -- -- O35945 Aldehyde dehydrogenase, cytosolic 1 Aldh1a7 492.6 444.8 638.3 657.6 550 614.1 0.864961299884723 0.282273726280441 -0.209292509783551 Nonsignificant None 3 Biological Process:metabolic process (GO:0008152),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) retinal dehydrogenase 1.2.1.36 ko00830 Retinol metabolism ko01100 Metabolic pathways Aldehyde dehydrogenase C Energy production and conversion ; IPR015590 [Aldehyde dehydrogenase domain] -- -- P62918 60S ribosomal protein L8 Rpl8 6802.7 6850.3 6297.6 5720.9 5569.4 5740.7 1.17142857142857 0.00624325288811501 0.228268987673117 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L8e -- ko03010 Ribosome 60s ribosomal protein L2/L8 J Translation, ribosomal structure and biogenesis ; IPR022666 [Ribosomal Proteins L2, RNA binding domain] ; IPR022669[Ribosomal protein L2, C-terminal] -- -- Q8C2Q8 ATP synthase subunit gamma Atp5c1 9670.5 9132.3 10037.6 10976.2 10630.6 10580.6 0.896015210921044 0.0185194591415975 -0.158404870936975 Nonsignificant None 1 Biological Process:ATP synthesis coupled proton transport (GO:0015986) F-type H+-transporting ATPase subunit gamma -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease F0F1-type ATP synthase, gamma subunit C Energy production and conversion ; IPR000131 [ATP synthase, F1 complex, gamma subunit] -- -- Q8BNM0 High mobility group protein B1 (Fragment) Hmgb1 8548.8 8035.2 7039.2 6647.2 6669.2 7260.3 1.14805581069851 0.105149634585171 0.199192777780865 Nonsignificant None -- -- high mobility group protein B1 -- ko03410 Base excision repair ko04140 Autophagy - animal ko04217 Necroptosis HMG box-containing protein R General function prediction only ; IPR009071 [High mobility group box domain] -- HMG Q3U4W5 Uncharacterized protein Rab6a 79.9 84.9 95.3 100.7 88.5 89.5 0.933261571582347 0.35903176050385 -0.099646603160818 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-6A -- -- GTPase Rab6/YPT6/Ryh1, small G protein superfamily U Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- Q6P069 Sorcin Sri 5862.7 5895.9 6240.5 8105.5 7548 7813.6 0.766992939050841 0.000823938294864446 -0.382714798571442 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) -- -- -- Ca2+-binding protein, EF-Hand protein superfamily T Signal transduction mechanisms ; IPR002048 [EF-hand domain] -- -- Q3U9G9 Delta(14)-sterol reductase LBR Lbr 5740 6407.8 4973.9 3822.4 3996.5 3870.4 1.46473270426801 0.0465965395060678 0.550637414537705 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) lamin-B receptor -- -- Sterol reductase/lamin B receptor IT Lipid transport and metabolism ; Signal transduction mechanisms ; IPR001171 [Ergosterol biosynthesis ERG4/ERG24] ; IPR019023[Lamin-B receptor of TUDOR domain] -- -- Q3TFC2 Uncharacterized protein Nono 6542 6625.9 6841.9 6059.8 6128.8 6092.7 1.09455016875168 0.00325363791559996 0.130338082020453 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) non-POU domain-containing octamer-binding protein -- -- RNA-binding protein p54nrb (RRM superfamily) A RNA processing and modification ; IPR000504 [RNA recognition motif domain] ; IPR012975[NOPS] -- -- Q61555 Fibrillin-2 Fbn2 3681.1 3873.7 4557.6 3792.9 3789.7 3831 1.06122520501857 0.473546484913436 0.0857308463440327 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) -- -- -- Fibrillins and related proteins containing Ca2+-binding EGF-like domains T Signal transduction mechanisms ; IPR001881 [EGF-like calcium-binding domain] ; IPR013032[EGF-like, conserved site] ; IPR017878[TB domain] ; IPR026823[Complement Clr-like EGF domain] -- -- Q9EP69 Phosphatidylinositol-3-phosphatase SAC1 Sacm1l 4187 3974.6 4205.7 4018 3890.7 4277.7 1.01484441672684 0.680131481400148 0.0212585683745977 Nonsignificant None 1 Molecular Function:phosphoric ester hydrolase activity (GO:0042578) phosphatidylinositol 4-phosphatase 3.1.3.- ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system Putative phosphoinositide phosphatase I Lipid transport and metabolism ; IPR002013 [SAC domain] -- -- Q3UIG0 Eukaryotic translation initiation factor 3 subunit E Eif3e 3041.8 3031.4 2375.2 2402.4 2373.6 2464.5 1.16682549547683 0.207915409562111 0.222588814999856 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) translation initiation factor 3 subunit E -- ko03013 RNA transport ko05160 Hepatitis C Translation initiation factor 3, subunit e (eIF-3e) J Translation, ribosomal structure and biogenesis ; IPR000717 [Proteasome component (PCI) domain] ; IPR019010[Eukaryotic translation initiation factor 3 subunit E, N-terminal] -- -- O88456 Calpain small subunit 1 Capns1 5081.9 5118.8 4977.7 5216.8 5353 4897.2 0.981340919376737 0.533999349241556 -0.0271736768416202 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) calpain, small subunit 1 -- -- Ca2+-binding protein, EF-Hand protein superfamily T Signal transduction mechanisms ; IPR002048 [EF-hand domain] -- -- Q5M9P3 40S ribosomal protein S19 (Fragment) Rps19 10134.2 10138.8 7335.9 6230.8 6333.9 6094 1.47967972045212 0.0847329224855282 0.56528493550333 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S19e -- ko03010 Ribosome 40S ribosomal protein S19 J Translation, ribosomal structure and biogenesis ; IPR001266 [Ribosomal protein S19e] -- -- B7ZWM4 NAD(P)H oxidase (H(2)O(2)-forming) Duox2 2737.7 2880.6 2689.6 1899.7 2344.9 2024.3 1.32525642457209 0.00927872987346254 0.406271534518125 Nonsignificant None 3 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) -- -- Ferric reductase, NADH/NADPH oxidase and related proteins PQ Inorganic ion transport and metabolism ; Secondary metabolites biosynthesis, transport and catabolism ; IPR002048 [EF-hand domain] ; IPR013112[FAD-binding 8] ; IPR013121[Ferric reductase, NAD binding domain] ; IPR013130[Ferric reductase transmembrane component-like domain] ; IPR019791[Haem peroxidase, animal] -- -- Q3V1T9 Plasminogen Plg 4528.1 4660 3578.4 2617.6 2657 2779.1 1.5851720327303 0.0415339986978878 0.664639419102084 Significant up 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) plasminogen 3.4.21.7 ko04080 Neuroactive ligand-receptor interaction ko04610 Complement and coagulation cascades ko05150 Staphylococcus aureus infection ko05164 Influenza A -- -- -- IPR000001 [Kringle] ; IPR001254[Serine proteases, trypsin domain] ; IPR003609[PAN/Apple domain] -- -- Q9CWS0 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 Ddah1 2761.4 2856.4 2828.9 2630.6 2512.9 2585.6 1.09284392749479 0.00574508530723934 0.12808737986912 Nonsignificant None -- -- dimethylargininase 3.5.3.18 -- -- -- -- -- -- -- Q3UXP2 RuvB-like helicase Ruvbl2 3701.8 3574.4 3907.8 3759.1 3923.7 3876.2 0.967557747209966 0.314438812751359 -0.0475803260052698 Nonsignificant None 2 Molecular Function:DNA helicase activity (GO:0003678),Molecular Function:ATP binding (GO:0005524) RuvB-like protein 2 3.6.4.12 -- DNA helicase TIP49, TBP-interacting protein K Transcription ; IPR010339 [TIP49, C-terminal] -- -- Q9CZW4 Fatty acid CoA ligase Acsl3 Acsl3 2729.5 2557.1 2987.9 3259.1 3129 3375.8 0.847458495068569 0.0261413727527626 -0.238785382007152 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) long-chain acyl-CoA synthetase 6.2.1.3 ko00061 Fatty acid biosynthesis ko00071 Fatty acid degradation ko01100 Metabolic pathways ko01212 Fatty acid metabolism ko03320 PPAR signaling pathway ko04146 Peroxisome ko04216 Ferroptosis ko04920 Adipocytokine signaling pathway Acyl-CoA synthetase I Lipid transport and metabolism ; IPR000873 [AMP-dependent synthetase/ligase] -- -- Q07797 Galectin-3-binding protein Lgals3bp 2247.3 2379.6 2645.1 2880.3 3085 3072.8 0.804593885883095 0.0118857863198335 -0.313667319936065 Nonsignificant None 2 Molecular Function:scavenger receptor activity (GO:0005044),Cellular Component:membrane (GO:0016020) galectin-3-binding protein -- -- -- -- -- IPR001190 [SRCR domain] ; IPR011705[BTB/Kelch-associated] -- -- H7BX01 Dynamin-like 120 kDa protein, mitochondrial Opa1 2843.3 2796.1 3132.5 3128.2 3169.6 3240.5 0.919650252141367 0.0811963344249868 -0.120842793974427 Nonsignificant None -- -- optic atrophy protein 1 3.6.5.5 -- Dynamin-like GTP binding protein R General function prediction only ; IPR022812 [Dynamin superfamily] -- -- P19536 Cytochrome c oxidase subunit 5B, mitochondrial Cox5b 7398.7 7319.5 8331.9 8728.3 8344.5 8984.1 0.884606380651574 0.0554245215608004 -0.176892446477176 Nonsignificant None 2 Molecular Function:cytochrome-c oxidase activity (GO:0004129),Cellular Component:mitochondrial envelope (GO:0005740) cytochrome c oxidase subunit 5b -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04260 Cardiac muscle contraction ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Cytochrome c oxidase, subunit Vb/COX4 C Energy production and conversion ; IPR002124 [Cytochrome c oxidase, subunit Vb] -- -- Q3U645 Uncharacterized protein Abcd3 3494.3 3000.3 3297.3 3004.1 2959.3 3022.9 1.0896475746414 0.200604474416942 0.123861598735069 Nonsignificant None 5 Molecular Function:ATP binding (GO:0005524),Biological Process:transport (GO:0006810),Cellular Component:integral component of membrane (GO:0016021),Molecular Function:ATPase activity (GO:0016887),Biological Process:transmembrane transport (GO:0055085) ATP-binding cassette, subfamily D (ALD), member 3 -- ko02010 ABC transporters ko04146 Peroxisome Long-chain acyl-CoA transporter, ABC superfamily (involved in peroxisome organization and biogenesis) IR Lipid transport and metabolism ; General function prediction only ; IPR003439 [ABC transporter-like] ; IPR011527[ABC transporter type 1, transmembrane domain] -- -- Q8JZQ2 AFG3-like protein 2 Afg3l2 4260.8 4041.8 4617.2 5371.3 5112.3 5284 0.819389127070702 0.00671888619468702 -0.287379345863697 Nonsignificant None 5 Molecular Function:metalloendopeptidase activity (GO:0004222),Molecular Function:ATP binding (GO:0005524),Biological Process:proteolysis (GO:0006508),Molecular Function:zinc ion binding (GO:0008270),Cellular Component:integral component of membrane (GO:0016021) AFG3 family protein 3.4.24.- -- AAA+-type ATPase containing the peptidase M41 domain O Posttranslational modification, protein turnover, chaperones ; IPR000642 [Peptidase M41] ; IPR003959[ATPase, AAA-type, core] ; IPR011546[Peptidase M41, FtsH extracellular] -- -- P58871 182 kDa tankyrase-1-binding protein Tnks1bp1 4530.9 4457.3 4160.9 4115.1 4159 4045.2 1.06735772324726 0.0787438105735045 0.0940437741591002 Nonsignificant None -- -- -- -- -- -- -- -- IPR032764 [Tankyrase 1-binding protein, C-terminal] -- -- P08228 Superoxide dismutase [Cu-Zn] Sod1 4796.2 4735.8 5287.6 5815.8 5445.4 6081.5 0.854515156232882 0.0296513882129349 -0.2268220141877 Nonsignificant None 3 Biological Process:superoxide metabolic process (GO:0006801),Molecular Function:metal ion binding (GO:0046872),Biological Process:oxidation-reduction process (GO:0055114) superoxide dismutase, Cu-Zn family 1.15.1.1 ko04146 Peroxisome ko04213 Longevity regulating pathway - multiple species ko05014 Amyotrophic lateral sclerosis (ALS) ko05016 Huntington's disease ko05020 Prion diseases Cu2+/Zn2+ superoxide dismutase SOD1 P Inorganic ion transport and metabolism ; IPR001424 [Superoxide dismutase, copper/zinc binding domain] -- -- Q91WT8 RNA-binding protein 47 Rbm47 3600.3 3532.4 3120.9 3083 3187.7 3145.1 1.08897810063935 0.141661225130379 0.122974941734633 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- Heterogeneous nuclear ribonucleoprotein R (RRM superfamily) A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- P54728 UV excision repair protein RAD23 homolog B Rad23b 6627.5 6686.3 5262.9 4895.4 5029 4961.3 1.24795609208838 0.117083482436399 0.319567175513695 Nonsignificant None 4 Molecular Function:damaged DNA binding (GO:0003684),Molecular Function:protein binding (GO:0005515),Biological Process:nucleotide-excision repair (GO:0006289),Biological Process:proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161) UV excision repair protein RAD23 -- ko03420 Nucleotide excision repair ko04141 Protein processing in endoplasmic reticulum Nucleotide excision repair factor NEF2, RAD23 component L Replication, recombination and repair ; IPR000626 [Ubiquitin domain] ; IPR015360[XPC-binding domain] ; IPR015940[Ubiquitin-associated domain] -- -- O55234 Proteasome subunit beta type-5 Psmb5 4895.3 4787.2 5264 4675.2 4667.8 5017.8 1.04078463595343 0.350401878040968 0.0576715702838342 Nonsignificant None 3 Molecular Function:threonine-type endopeptidase activity (GO:0004298),Cellular Component:proteasome core complex (GO:0005839),Biological Process:proteolysis involved in cellular protein catabolic process (GO:0051603) 20S proteasome subunit beta 5 3.4.25.1 ko03050 Proteasome 20S proteasome, regulatory subunit beta type PSMB5/PSMB8/PRE2 O Posttranslational modification, protein turnover, chaperones ; IPR001353 [Proteasome, subunit alpha/beta] -- -- A0JNY7 Eukaryotic translation initiation factor 4, gamma 2 Eif4g2 3895.9 3789.2 4055.6 3878.8 3938.6 3759.7 1.01413134550103 0.591328820031374 0.0202445154886205 Nonsignificant None 2 Molecular Function:RNA binding (GO:0003723),Molecular Function:protein binding (GO:0005515) translation initiation factor 4G -- ko03013 RNA transport ko05416 Viral myocarditis Translation initiation factor 4F, ribosome/mRNA-bridging subunit (eIF-4G) J Translation, ribosomal structure and biogenesis ; IPR003307 [W2 domain] ; IPR003890[MIF4G-like, type 3] ; IPR003891[Initiation factor eIF-4 gamma, MA3] -- -- P31809 Carcinoembryonic antigen-related cell adhesion molecule 1 Ceacam1 2426.9 2163.6 2769 2354.4 2129.5 2025.8 1.13054365024502 0.230204992196278 0.177016695562502 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) carcinoembryonic antigen-related cell adhesion molecule -- -- -- -- -- IPR007110 [Immunoglobulin-like domain] ; IPR013106[Immunoglobulin V-set domain] -- -- E0CXB9 Catenin alpha-2 Ctnna2 57.6 53.9 71.2 60.9 79.3 70.8 0.865876777251185 0.275727914592533 -0.207766364967059 Nonsignificant None 2 Biological Process:cell adhesion (GO:0007155),Molecular Function:actin filament binding (GO:0051015) catenin alpha -- ko04390 Hippo signaling pathway ko04520 Adherens junction ko04670 Leukocyte transendothelial migration ko05100 Bacterial invasion of epithelial cells ko05200 Pathways in cancer ko05213 Endometrial cancer ko05226 Gastric cancer ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) Alpha-catenin W Extracellular structures ; IPR006077 [Vinculin/alpha-catenin] -- -- A0A0R4J1Q0 Enhancer of mRNA-decapping protein 4 Edc4 1944.8 1891.6 1655.9 1714.7 1776.9 1802.6 1.03741830682634 0.514865183025392 0.0529977335902934 Nonsignificant None -- -- enhancer of mRNA-decapping protein 4 -- ko03018 RNA degradation Nuclear protein, contains WD40 repeats R General function prediction only ; IPR032401 [Enhancer of mRNA-decapping protein 4, WD40 repeat region] -- -- P60766 Cell division control protein 42 homolog Cdc42 4574.6 4503.3 4710.1 4766.2 4774.1 4622.8 0.973515685125432 0.184541495884458 -0.0387238712880906 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) cell division control protein 42 -- ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04062 Chemokine signaling pathway ko04144 Endocytosis ko04360 Axon guidance ko04370 VEGF signaling pathway ko04510 Focal adhesion ko04520 Adherens junction ko04530 Tight junction ko04660 T cell receptor signaling pathway ko04666 Fc gamma R-mediated phagocytosis ko04670 Leukocyte transendothelial migration ko04722 Neurotrophin signaling pathway ko04810 Regulation of actin cytoskeleton ko04912 GnRH signaling pathway ko04932 Non-alcoholic fatty liver disease (NAFLD) ko04933 AGE-RAGE signaling pathway in diabetic complications ko05100 Bacterial invasion of epithelial cells ko05132 Salmonella infection ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05205 Proteoglycans in cancer ko05211 Renal cell carcinoma ko05212 Pancreatic cancer Ras-related small GTPase, Rho type R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- Q9EPE9 Endoplasmic reticulum transmembrane helix translocase Atp13a1 2628.6 2662.5 2784.6 2866.7 2862.2 2824.7 0.944128787878788 0.0317539484010511 -0.0829444249602574 Nonsignificant None 2 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:metal ion binding (GO:0046872) manganese-transporting P-type ATPase 3.6.3.- -- P-type ATPase P Inorganic ion transport and metabolism ; IPR008250 [P-type ATPase, A domain] -- -- P70333 Heterogeneous nuclear ribonucleoprotein H2 Hnrnph2 1302.3 1309.5 1410.3 1299.1 1341.2 1282.3 1.02536582878703 0.443169629069937 0.0361387245750304 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) heterogeneous nuclear ribonucleoprotein F/H -- -- Splicing factor hnRNP-F and related RNA-binding proteins A RNA processing and modification ; IPR000504 [RNA recognition motif domain] ; IPR012996[Zinc finger, CHHC-type] -- -- Q3URM4 Thioredoxin domain-containing protein Erp44 5812.7 5938.1 6354.2 5974.8 6047.8 5822.8 1.0145471662165 0.649731023873506 0.0208359374305856 Nonsignificant None 1 Biological Process:cell redox homeostasis (GO:0045454) endoplasmic reticulum resident protein 44 -- -- Thiol-disulfide isomerase and thioredoxin OC Posttranslational modification, protein turnover, chaperones ; Energy production and conversion ; IPR013766 [Thioredoxin domain] -- -- Q91YR7 Pre-mRNA-processing factor 6 Prpf6 2810.6 2858.4 3034.9 2968.7 2962.8 2786.2 0.99841701366186 0.96200842435087 -0.0022855760353015 Nonsignificant None 1 Cellular Component:nucleus (GO:0005634) pre-mRNA-processing factor 6 -- ko03040 Spliceosome HAT repeat protein A RNA processing and modification ; IPR010491 [PRP1 splicing factor, N-terminal] -- -- Q78ZJ8 RAB11B protein Rab11b 5901.7 5651 5519.8 5484.5 5500 5534.2 1.03352564063758 0.239808719977227 0.0475741808889704 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-11B -- ko04144 Endocytosis ko04152 AMPK signaling pathway ko04962 Vasopressin-regulated water reabsorption GTPase Rab11/YPT3, small G protein superfamily U Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- M0QWP1 Agrin Agrn 1853.2 1913.2 2043.3 2090.8 2030.8 2082.6 0.936414042100513 0.0903607550846177 -0.0947815261819065 Nonsignificant None 4 Molecular Function:protein binding (GO:0005515),Biological Process:G-protein coupled acetylcholine receptor signaling pathway (GO:0007213),Biological Process:receptor clustering (GO:0043113),Molecular Function:laminin binding (GO:0043236) agrin -- ko04512 ECM-receptor interaction Basement membrane-specific heparan sulfate proteoglycan (HSPG) core protein O Posttranslational modification, protein turnover, chaperones ; IPR000082 [SEA domain] ; IPR000742[EGF-like domain] ; IPR001791[Laminin G domain] ; IPR002049[Laminin EGF domain] ; IPR002350[Kazal domain] ; IPR004850[NtA (N-terminal agrin) domain] -- -- H3BKU1 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Ppp2r1b 250.9 241.1 233.3 172.4 212.5 182.8 1.27761141447948 0.0157870516807543 0.353449107294607 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) serine/threonine-protein phosphatase 2A regulatory subunit A -- ko03015 mRNA surveillance pathway ko04071 Sphingolipid signaling pathway ko04114 Oocyte meiosis ko04151 PI3K-Akt signaling pathway ko04152 AMPK signaling pathway ko04261 Adrenergic signaling in cardiomyocytes ko04350 TGF-beta signaling pathway ko04390 Hippo signaling pathway ko04530 Tight junction ko04728 Dopaminergic synapse ko04730 Long-term depression ko05142 Chagas disease (American trypanosomiasis) ko05160 Hepatitis C ko05165 Human papillomavirus infection Protein phosphatase 2A regulatory subunit A and related proteins T Signal transduction mechanisms ; IPR000357 [HEAT repeat] -- -- Q9EQ06 Estradiol 17-beta-dehydrogenase 11 Hsd17b11 3406.9 3320.9 4033.7 3539.1 3459.6 3661.7 1.00948369667179 0.891627697439239 0.0136176110946634 Nonsignificant None -- -- -- -- -- Hydroxysteroid 17-beta dehydrogenase 11 Q Secondary metabolites biosynthesis, transport and catabolism ; IPR002347 [Short-chain dehydrogenase/reductase SDR] -- -- E9PUL3 Chloride channel accessory 3B Clca3b 3487.9 3447.1 3424.3 2512.5 2722.3 2710.5 1.30382741998414 0.000337065713176279 0.3827529210948 Nonsignificant None -- -- calcium-activated chloride channel regulator 3/4 -- ko04924 Renin secretion ko04972 Pancreatic secretion -- -- -- IPR002035 [von Willebrand factor, type A] ; IPR013642[Calcium-activated chloride channel protein] -- -- Q45VK6 Nuclear factor 90 Ilf3 4007.3 4106.2 4282.3 4168.6 4272.7 4340.7 0.969785636050696 0.245700577455597 -0.044262209426882 Nonsignificant None -- -- interleukin enhancer-binding factor 3 -- -- Transcription factor NFAT, subunit NF90 R General function prediction only ; IPR006561 [DZF domain] ; IPR014720[Double-stranded RNA-binding domain] -- -- Q91WT7 3-alpha-hydroxysteroid dehydrogenase type 1 Akr1c14 3332 2826.9 3081.9 6124.1 6710.4 6117.9 0.48757940946793 0.000188554461853106 -1.03629089281303 Significant down -- -- -- -- -- Aldo/keto reductase family proteins R General function prediction only ; IPR023210 [NADP-dependent oxidoreductase domain] -- -- Q9DCM0 Persulfide dioxygenase ETHE1, mitochondrial Ethe1 3991.1 3501.6 4239.2 6091 5652 5866.4 0.666229400206708 0.0014545011262431 -0.585909074413793 Significant down -- -- sulfur dioxygenase 1.13.11.18 ko00920 Sulfur metabolism Glyoxylase R General function prediction only ; IPR001279 [Metallo-beta-lactamase] -- -- Q9R1T2 SUMO-activating enzyme subunit 1 Sae1 4918.9 5110.5 4738.1 4179.6 4173.9 4387.1 1.1590898387831 0.00624119537854645 0.212992391144924 Nonsignificant None 1 Molecular Function:small protein activating enzyme activity (GO:0008641) ubiquitin-like 1-activating enzyme E1 A 6.2.1.45 ko04120 Ubiquitin mediated proteolysis SMT3/SUMO-activating complex, AOS1/RAD31 component O Posttranslational modification, protein turnover, chaperones ; IPR000594 [THIF-type NAD/FAD binding fold] -- -- Q3U7U8 Uncharacterized protein Rap1a 34.4 38.5 50.3 51.5 46.9 39.3 0.894698620188816 0.461978709293682 -0.160526303440063 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rap-1A -- ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04024 cAMP signaling pathway ko04062 Chemokine signaling pathway ko04510 Focal adhesion ko04530 Tight junction ko04611 Platelet activation ko04670 Leukocyte transendothelial migration ko04720 Long-term potentiation ko04722 Neurotrophin signaling pathway ko04972 Pancreatic secretion ko05211 Renal cell carcinoma Ras-related GTPase R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- Q9DBF1 Alpha-aminoadipic semialdehyde dehydrogenase Aldh7a1 3194.1 3095.4 3424 3540.4 3660.2 3661.3 0.89427264106648 0.0220481721145958 -0.161213355258324 Nonsignificant None 3 Biological Process:metabolic process (GO:0008152),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00010 Glycolysis / Gluconeogenesis ko00053 Ascorbate and aldarate metabolism ko00071 Fatty acid degradation ko00260 Glycine, serine and threonine metabolism ko00280 Valine, leucine and isoleucine degradation ko00310 Lysine degradation ko00330 Arginine and proline metabolism ko00340 Histidine metabolism ko00380 Tryptophan metabolism ko00410 beta-Alanine metabolism ko00561 Glycerolipid metabolism ko00620 Pyruvate metabolism ko01100 Metabolic pathways Aldehyde dehydrogenase C Energy production and conversion ; IPR015590 [Aldehyde dehydrogenase domain] -- -- Q99L13 3-hydroxyisobutyrate dehydrogenase, mitochondrial Hibadh 2663.4 2479.6 2762.6 3342.5 3253 3495.1 0.783461835767942 0.0026027101924504 -0.352065095479029 Nonsignificant None 3 Molecular Function:phosphogluconate dehydrogenase (decarboxylating) activity (GO:0004616),Molecular Function:NAD binding (GO:0051287),Biological Process:oxidation-reduction process (GO:0055114) 3-hydroxyisobutyrate dehydrogenase 1.1.1.31 ko00280 Valine, leucine and isoleucine degradation ko01100 Metabolic pathways Predicted dehydrogenase R General function prediction only ; IPR006115 [6-phosphogluconate dehydrogenase, NADP-binding] ; IPR029154[3-hydroxyisobutyrate dehydrogenase, NAD-binding domain] -- -- Q5EBQ6 60S ribosomal protein L9 Rpl9 5282 5264.5 5147.5 4602.8 4622.3 4884.6 1.11228445679214 0.00620759909157731 0.153525791589135 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412),Molecular Function:rRNA binding (GO:0019843) large subunit ribosomal protein L9e -- ko03010 Ribosome 60S ribosomal protein L9 J Translation, ribosomal structure and biogenesis ; IPR020040 [Ribosomal protein L6, alpha-beta domain] -- -- Q921F4 Heterogeneous nuclear ribonucleoprotein L-like Hnrnpll 3693.5 3808.5 3562.7 3860.3 3754.4 3727.7 0.975516645507124 0.320719802616229 -0.0357616047432739 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) heterogeneous nuclear ribonucleoprotein L -- -- Heterogeneous nuclear ribonucleoprotein L (contains RRM repeats) A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- Q9R1P3 Proteasome subunit beta type-2 Psmb2 4451.6 4771.3 4169.7 4345.5 4302 4321.1 1.03269435405518 0.501692121958625 0.0464133237703915 Nonsignificant None 3 Molecular Function:threonine-type endopeptidase activity (GO:0004298),Cellular Component:proteasome core complex (GO:0005839),Biological Process:proteolysis involved in cellular protein catabolic process (GO:0051603) 20S proteasome subunit beta 4 3.4.25.1 ko03050 Proteasome 20S proteasome, regulatory subunit beta type PSMB2/PRE1 O Posttranslational modification, protein turnover, chaperones ; IPR001353 [Proteasome, subunit alpha/beta] -- -- P26369 Splicing factor U2AF 65 kDa subunit U2af2 4909.6 4926.3 4066.4 3561.9 3529.7 3567.7 1.30424136669387 0.0623242344349268 0.383210883609736 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) splicing factor U2AF 65 kDa subunit -- ko03040 Spliceosome Splicing factor U2AF, large subunit (RRM superfamily) A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- Q3U2R0 Uncharacterized protein Hsd11b2 3638.1 3300.4 3951 4831.3 5340.5 5583.1 0.691181791061828 0.00504535428127238 -0.532862884172487 Nonsignificant None -- -- corticosteroid 11-beta-dehydrogenase isozyme 2 1.1.1.- ko00140 Steroid hormone biosynthesis ko04960 Aldosterone-regulated sodium reabsorption Corticosteroid 11-beta-dehydrogenase and related short chain-type dehydrogenases QR Secondary metabolites biosynthesis, transport and catabolism ; General function prediction only ; IPR002347 [Short-chain dehydrogenase/reductase SDR] -- -- A0A171KXD3 Protein arginine N-methyltransferase 1 Prmt1 5458.3 5891.3 5648.7 4788.6 4778 5579.5 1.12228890605502 0.103241372240336 0.166444110599387 Nonsignificant None -- -- type I protein arginine methyltransferase 2.1.1.319 ko04068 FoxO signaling pathway ko04922 Glucagon signaling pathway Protein arginine N-methyltransferase PRMT1 and related enzymes OKT Posttranslational modification, protein turnover, chaperones ; Transcription ; Signal transduction mechanisms ; -- -- -- P14576 Signal recognition particle 54 kDa protein Srp54 4258.9 4146.3 4348.5 3951.7 4054.1 4065.7 1.05651327506938 0.0297903898603058 0.0793108948227236 Nonsignificant None 4 Molecular Function:GTP binding (GO:0005525),Biological Process:SRP-dependent cotranslational protein targeting to membrane (GO:0006614),Molecular Function:7S RNA binding (GO:0008312),Cellular Component:signal recognition particle (GO:0048500) signal recognition particle subunit SRP54 3.6.5.4 ko03060 Protein export Signal recognition particle, subunit Srp54 U Intracellular trafficking, secretion, and vesicular transport ; IPR000897 [Signal recognition particle, SRP54 subunit, GTPase domain] ; IPR004125[Signal recognition particle, SRP54 subunit, M-domain] ; IPR013822[Signal recognition particle, SRP54 subunit, helical bundle] -- -- Q61941 NAD(P) transhydrogenase, mitochondrial Nnt 3424.9 3445.5 4275.2 4226.5 4145.6 5762.7 0.788521945835809 0.169864213201062 -0.342777186786103 Nonsignificant None -- -- NAD(P) transhydrogenase 1.6.1.2 ko00760 Nicotinate and nicotinamide metabolism ko01100 Metabolic pathways -- -- -- IPR007698 [Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain] ; IPR007886[Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal] ; IPR024605[NAD(P) transhydrogenase, alpha subunit, C-terminal] ; IPR034300[NADP transhydrogenase beta-like domain] -- -- Q8JZN5 Complex I assembly factor ACAD9, mitochondrial Acad9 3366.8 3230.2 3745.4 3927.3 3850.3 3996.2 0.878424977492398 0.0404718124127757 -0.187009017784578 Nonsignificant None 4 Molecular Function:acyl-CoA dehydrogenase activity (GO:0003995),Biological Process:metabolic process (GO:0008152),Molecular Function:flavin adenine dinucleotide binding (GO:0050660),Biological Process:oxidation-reduction process (GO:0055114) acyl-CoA dehydrogenase family member 9 1.3.99.- -- Very-long-chain acyl-CoA dehydrogenase I Lipid transport and metabolism ; IPR006091 [Acyl-CoA oxidase/dehydrogenase, central domain] ; IPR009075[Acyl-CoA dehydrogenase/oxidase C-terminal] ; IPR013786[Acyl-CoA dehydrogenase/oxidase, N-terminal] -- -- P62242 40S ribosomal protein S8 Rps8 8300.6 8111.3 8108.3 6987.7 6944.6 7044.5 1.16891994965867 0.0000718109118043809 0.225176134159717 Nonsignificant None -- -- small subunit ribosomal protein S8e -- ko03010 Ribosome 40S ribosomal protein S8 J Translation, ribosomal structure and biogenesis ; IPR022309 [Ribosomal protein S8e/ribosomal biogenesis NSA2] -- -- Q3TQP6 Malic enzyme Me1 2001.4 1912.7 2590.4 2019.8 1749.1 2092.7 1.10967995086666 0.4169458527678 0.150143640650442 Nonsignificant None 3 Molecular Function:malate dehydrogenase (decarboxylating) (NAD+) activity (GO:0004471),Molecular Function:NAD binding (GO:0051287),Biological Process:oxidation-reduction process (GO:0055114) malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) 1.1.1.40 ko00620 Pyruvate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism NADP+-dependent malic enzyme C Energy production and conversion ; IPR012301 [Malic enzyme, N-terminal domain] ; IPR012302[Malic enzyme, NAD-binding] -- -- Q8BK67 Protein RCC2 Rcc2 4366.6 4469.9 4037.2 3909.8 3818.6 4178.5 1.08119661708757 0.129855362229352 0.11262890300206 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein, contains RCC1 domain S Function unknown ; IPR000408 [Regulator of chromosome condensation, RCC1] -- -- P62983 Ubiquitin-40S ribosomal protein S27a Rps27a 3940.1 4000.6 4332 4345.3 4532.5 4452.2 0.920682670667667 0.0573829040428719 -0.119224102893257 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Molecular Function:protein binding (GO:0005515),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S27Ae -- ko03010 Ribosome Ubiquitin/40S ribosomal protein S27a fusion J Translation, ribosomal structure and biogenesis ; IPR000626 [Ubiquitin domain] ; IPR002906[Ribosomal protein S27a] -- -- Q3UKJ7 WD40 repeat-containing protein SMU1 Smu1 2492 2650 2214.2 2099.2 2169.6 2263.6 1.1261098524279 0.113592275561414 0.171347569711786 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) WD40 repeat-containing protein SMU1 -- -- Conserved WD40 repeat-containing protein R General function prediction only ; IPR001680 [WD40 repeat] -- -- Q9QYB1 Chloride intracellular channel protein 4 Clic4 3202.3 3465.1 3696.5 3783.2 3641.2 3622.8 0.938147222825693 0.207134042901856 -0.0921137531979359 Nonsignificant None -- -- chloride intracellular channel protein 4 -- -- Intracellular Cl- channel CLIC, contains GST domain P Inorganic ion transport and metabolism ; -- -- -- E9Q852 Afadin Afdn 3390.5 3267.2 3498.4 3374.5 3496.6 3479.6 0.981199339175128 0.446619626988978 -0.0273818326276874 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Biological Process:signal transduction (GO:0007165) afadin -- ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04024 cAMP signaling pathway ko04520 Adherens junction ko04530 Tight junction ko04670 Leukocyte transendothelial migration Actin filament-binding protein Afadin Z Cytoskeleton ; IPR000159 [Ras-associating (RA) domain] ; IPR000253[Forkhead-associated (FHA) domain] ; IPR001478[PDZ domain] ; IPR002710[Dilute domain] -- -- Q8BGH2 Sorting and assembly machinery component 50 homolog Samm50 4168.7 4023 4093.8 4469.1 4341.4 4630.7 0.914018093622593 0.014705480060288 -0.129705370171615 Nonsignificant None 1 Cellular Component:outer membrane (GO:0019867) outer membrane protein insertion porin family -- -- Predicted cell surface protein homologous to bacterial outer membrane proteins R General function prediction only ; IPR000184 [Bacterial surface antigen (D15)] -- -- Q8BK48 Pyrethroid hydrolase Ces2e Ces2e 3526.6 3445.2 6013.3 4687.6 4607.6 4107 0.968878243870409 0.879703608988596 -0.0456127171737838 Nonsignificant None -- -- -- -- ko00983 Drug metabolism - other enzymes Carboxylesterase and related proteins R General function prediction only ; IPR002018 [Carboxylesterase, type B] -- -- P26645 Myristoylated alanine-rich C-kinase substrate Marcks 1985.9 1909.5 3162.1 3061 3415.1 2987.1 0.745783667258433 0.133167508457479 -0.423170892604555 Nonsignificant None 1 Molecular Function:calmodulin binding (GO:0005516) myristoylated alanine-rich C-kinase substrate -- ko04666 Fc gamma R-mediated phagocytosis ko05206 MicroRNAs in cancer -- -- -- IPR002101 [Myristoylated alanine-rich C-kinase substrate MARCKS] -- -- P70460 Vasodilator-stimulated phosphoprotein Vasp 5322.7 5197.2 4565 5212.3 5376.4 5378.1 0.944766640779618 0.289250946573511 -0.0819700700670638 Nonsignificant None -- -- vasodilator-stimulated phosphoprotein -- ko04015 Rap1 signaling pathway ko04022 cGMP-PKG signaling pathway ko04510 Focal adhesion ko04530 Tight junction ko04611 Platelet activation ko04666 Fc gamma R-mediated phagocytosis ko04670 Leukocyte transendothelial migration Signal transduction protein Enabled, contains WH1 domain T Signal transduction mechanisms ; IPR000697 [WH1/EVH1 domain] ; IPR014885[VASP tetramerisation] -- -- O35593 26S proteasome non-ATPase regulatory subunit 14 Psmd14 5668.7 4905 4113.3 3971 4067.9 4337.6 1.18668444228982 0.171002850079549 0.246936351098022 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) 26S proteasome regulatory subunit N11 -- ko03050 Proteasome ko05169 Epstein-Barr virus infection 26S proteasome regulatory complex, subunit RPN11 O Posttranslational modification, protein turnover, chaperones ; IPR000555 [JAB1/MPN/MOV34 metalloenzyme domain] ; IPR024969[Rpn11/EIF3F, C-terminal] -- -- Q3TKT4 Transcription activator BRG1 Smarca4 2440.5 2461.6 2464.8 2270.1 2396.3 2418.3 1.03983231470634 0.1147869925041 0.0563508954368681 Nonsignificant None 4 Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Cellular Component:nucleus (GO:0005634),Molecular Function:histone binding (GO:0042393) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2/4 3.6.4.- ko05225 Hepatocellular carcinoma Chromatin remodeling complex SWI/SNF, component SWI2 and related ATPases (DNA/RNA helicase superfamily) BK Chromatin structure and dynamics ; Transcription ; IPR000330 [SNF2-related, N-terminal domain] ; IPR001487[Bromodomain] ; IPR001650[Helicase, C-terminal] ; IPR006576[BRK domain] ; IPR014012[Helicase/SANT-associated domain] ; IPR014978[Glutamine-Leucine-Glutamine, QLQ] ; IPR029295[Snf2, ATP coupling domain] -- -- Q9R190 Metastasis-associated protein MTA2 Mta2 4109.9 4152.9 3929.3 3500.7 3607.4 3518.1 1.1473621802714 0.0023606853651167 0.198320869299022 Nonsignificant None 3 Molecular Function:chromatin binding (GO:0003682),Molecular Function:zinc ion binding (GO:0008270),Molecular Function:sequence-specific DNA binding (GO:0043565) metastasis-associated protein MTA -- -- Histone deacetylase complex, MTA1 component B Chromatin structure and dynamics ; IPR000679 [Zinc finger, GATA-type] ; IPR000949[ELM2 domain] ; IPR001025[Bromo adjacent homology (BAH) domain] -- zf-GATA Q3UI57 DNA replication licensing factor MCM3 Mcm3 3190.7 3252 3242.9 2968 2973.3 2827.4 1.10456510087014 0.00402723504294614 0.143478450775311 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Molecular Function:ATP binding (GO:0005524),Biological Process:DNA replication (GO:0006260) DNA replication licensing factor MCM3 3.6.4.12 ko03030 DNA replication ko04110 Cell cycle DNA replication licensing factor, MCM3 component L Replication, recombination and repair ; IPR001208 [MCM domain] ; IPR027925[MCM N-terminal domain] ; IPR033762[MCM OB domain] -- -- Q5M9M4 40S ribosomal protein S15a Rps15a 5496.1 5681.1 5208 4832.6 4862.8 4829.2 1.12809991325062 0.045139560821663 0.173894849622997 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S15Ae -- ko03010 Ribosome 40S ribosomal protein S15/S22 J Translation, ribosomal structure and biogenesis ; IPR000630 [Ribosomal protein S8] -- -- P43274 Histone H1.4 H1-4 1953.4 1917 2095.5 1968.7 1942.3 2169.5 0.98115286571828 0.693287352390117 -0.0274501659529423 Nonsignificant None 4 Cellular Component:nucleosome (GO:0000786),Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634),Biological Process:nucleosome assembly (GO:0006334) histone H1/5 -- -- Histone H1 B Chromatin structure and dynamics ; IPR005818 [Linker histone H1/H5, domain H15] -- -- Q9CZ42 ATP-dependent (S)-NAD(P)H-hydrate dehydratase Naxd 2970.4 2922.8 3045.1 3279 3251.7 3395.1 0.90051179753773 0.00434164423339884 -0.151182917992139 Nonsignificant None 1 Molecular Function:ADP-dependent NAD(P)H-hydrate dehydratase activity (GO:0052855) ATP-dependent NAD(P)H-hydrate dehydratase 4.2.1.93 -- Predicted sugar kinase G Carbohydrate transport and metabolism ; IPR000631 [ATP-dependent (S)-NAD(P)H-hydrate dehydratase] -- -- Q91VB8 Alpha globin 1 Hba-a1 5524 5175.8 5261.8 4968.1 8029.9 5612.3 0.857675588249518 0.443760300463349 -0.221496036587967 Nonsignificant None 2 Molecular Function:oxygen binding (GO:0019825),Molecular Function:heme binding (GO:0020037) hemoglobin subunit alpha -- ko05143 African trypanosomiasis ko05144 Malaria Globins and related hemoproteins C Energy production and conversion ; IPR000971 [Globin] -- -- Q5SUH7 Clathrin interactor 1 Clint1 4505.3 4585.4 5760.2 5291.1 5160.2 5123.4 0.953527194745324 0.613254995513703 -0.068654009873467 Nonsignificant None -- -- -- -- -- Predicted equilibrative nucleoside transporter protein F Nucleotide transport and metabolism ; IPR013809 [ENTH domain] -- -- Q571F9 MKIAA4115 protein (Fragment) G3bp1 4434.6 4482.6 4045.7 3222.2 3397.4 3400.7 1.29366386235941 0.00285228722018648 0.371462805039755 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Cellular Component:intracellular (GO:0005622),Biological Process:transport (GO:0006810) -- -- -- RasGAP SH3 binding protein rasputin, contains NTF2 and RRM domains T Signal transduction mechanisms ; IPR000504 [RNA recognition motif domain] ; IPR002075[Nuclear transport factor 2] -- -- Q08943 FACT complex subunit SSRP1 Ssrp1 3785.2 4208.3 4346.6 3630.5 3722.4 3682.8 1.11819821125982 0.120179315124832 0.161175942255944 Nonsignificant None -- -- structure-specific recognition protein 1 -- -- Nucleosome-binding factor SPN, POB3 subunit KLB Transcription ; Replication, recombination and repair ; Chromatin structure and dynamics ; IPR009071 [High mobility group box domain] ; IPR013719[Domain of unknown function DUF1747] ; IPR024954[SSRP1 domain] -- HMG O08677 Kininogen-1 Kng1 4810.7 4904.2 4146 2945.9 2931 2889.8 1.58108524302189 0.0187804879700056 0.660915151611345 Significant up 1 Molecular Function:cysteine-type endopeptidase inhibitor activity (GO:0004869) kininogen -- ko04610 Complement and coagulation cascades -- -- -- IPR000010 [Cystatin domain] -- -- Q6NZB3 Ribonucleoside-diphosphate reductase Rrm1 2795.9 2710 2395.3 1860.4 2046.5 1977.2 1.3428051868595 0.00726692664735786 0.425250014863345 Nonsignificant None 3 Molecular Function:ATP binding (GO:0005524),Biological Process:DNA replication (GO:0006260),Biological Process:oxidation-reduction process (GO:0055114) ribonucleoside-diphosphate reductase subunit M1 1.17.4.1 ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko00480 Glutathione metabolism ko01100 Metabolic pathways Ribonucleotide reductase, alpha subunit F Nucleotide transport and metabolism ; IPR000788 [Ribonucleotide reductase large subunit, C-terminal] ; IPR005144[ATP-cone domain] ; IPR013509[Ribonucleotide reductase large subunit, N-terminal] -- -- P57016 Ladinin-1 Lad1 5849.6 5529.4 5682.7 4414.1 4525.7 4213.6 1.29713230039381 0.000556494996445614 0.375325634090715 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q5I0T6 Aldo-keto reductase family 1, member C19 Akr1c19 3063 3163.6 3771.8 2322.4 2260.7 2982.4 1.32157821690569 0.064347290277052 0.402261812646987 Nonsignificant None -- -- -- -- -- Aldo/keto reductase family proteins R General function prediction only ; IPR023210 [NADP-dependent oxidoreductase domain] -- -- Q8R5H1 Ubiquitin carboxyl-terminal hydrolase 15 Usp15 2275.1 2158.6 2165.9 2202.2 2241.7 2126.5 1.00444417387069 0.856871611153612 0.00639738256992501 Nonsignificant None 3 Molecular Function:thiol-dependent ubiquitin-specific protease activity (GO:0004843),Biological Process:protein deubiquitination (GO:0016579),Molecular Function:thiol-dependent ubiquitinyl hydrolase activity (GO:0036459) ubiquitin carboxyl-terminal hydrolase 15 3.4.19.12 ko04137 Mitophagy - animal Ubiquitin C-terminal hydrolase O Posttranslational modification, protein turnover, chaperones ; IPR001394 [Peptidase C19, ubiquitin carboxyl-terminal hydrolase] ; IPR006615[Peptidase C19, ubiquitin-specific peptidase, DUSP domain] ; IPR028135[Ubiquitin-like domain, USP-type] ; IPR029346[Ubiquitin carboxyl-terminal hydrolase, C-terminal] -- -- Q9D6J6 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial Ndufv2 3026.4 3103.3 3992.4 4609.1 4426.9 4421.5 0.752153074493777 0.0244989493616839 -0.410901792905437 Nonsignificant None -- -- -- -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease NADH:ubiquinone oxidoreductase, NDUFV2/24 kD subunit C Energy production and conversion ; -- -- -- O35295 Transcriptional activator protein Pur-beta Purb 2340.6 2372.3 2475.3 2728.7 2634 2552.2 0.90818582673186 0.0205819781097111 -0.138940572839069 Nonsignificant None -- -- transcriptional activator protein Pur-beta -- -- Transcriptional regulator of the PUR family, single-stranded-DNA-binding K Transcription ; IPR006628 [Purine-rich element binding protein family] -- -- Q80SW1 S-adenosylhomocysteine hydrolase-like protein 1 Ahcyl1 1118 1092.8 1070.2 1001.6 1060 1010.6 1.06796432523924 0.0379634231175061 0.0948634553962092 Nonsignificant None 3 Molecular Function:adenosylhomocysteinase activity (GO:0004013),Biological Process:S-adenosylhomocysteine catabolic process (GO:0019510),Molecular Function:NAD binding (GO:0051287) adenosylhomocysteinase 3.3.1.1 ko00270 Cysteine and methionine metabolism ko01100 Metabolic pathways S-adenosylhomocysteine hydrolase H Coenzyme transport and metabolism ; IPR000043 [Adenosylhomocysteinase] ; IPR015878[S-adenosyl-L-homocysteine hydrolase, NAD binding domain] -- -- Q99KP6 Pre-mRNA-processing factor 19 Prpf19 4612.1 4666.5 4757.6 4354.9 4375.6 4394.9 1.06939217090527 0.00231120917115679 0.0967910198167297 Nonsignificant None 3 Molecular Function:ubiquitin-protein transferase activity (GO:0004842),Molecular Function:protein binding (GO:0005515),Biological Process:protein ubiquitination (GO:0016567) pre-mRNA-processing factor 19 2.3.2.27 ko03040 Spliceosome ko04120 Ubiquitin mediated proteolysis mRNA splicing factor R General function prediction only ; IPR001680 [WD40 repeat] ; IPR003613[U box domain] ; IPR013915[Pre-mRNA-splicing factor 19] -- -- Q1WWK3 Hist1h1b protein (Fragment) H1f5 9114.1 9096.1 9473.8 8772.4 8665.6 9154.4 1.04104932236278 0.132064096356075 0.0580384216080663 Nonsignificant None 4 Cellular Component:nucleosome (GO:0000786),Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634),Biological Process:nucleosome assembly (GO:0006334) histone H1/5 -- -- Histone H1 B Chromatin structure and dynamics ; IPR005818 [Linker histone H1/H5, domain H15] -- -- Q922Q8 Leucine-rich repeat-containing protein 59 Lrrc59 5333.9 5049 4839.8 4250.1 4426.4 4354.1 1.16822709621967 0.00861423996880352 0.224320752593925 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Leucine-rich repeat protein S Function unknown ; IPR001611 [Leucine-rich repeat] -- -- A0A0G2JFY5 Far upstream element-binding protein 1 Fubp1 3634.1 3768.1 4121.3 3717.8 3864.1 3556.6 1.03456479777349 0.49302554995098 0.0490240081740876 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) far upstream element-binding protein -- -- K-homology type RNA binding proteins A RNA processing and modification ; IPR004088 [K Homology domain, type 1] ; IPR015096[Domain of unknown function DUF1897] -- -- Q3TH92 Fructose-bisphosphatase Fbp2 3807.9 3419.1 3730.6 3912.4 3998.6 4210.7 0.903965615383981 0.0589518025519314 -0.145660197754041 Nonsignificant None -- -- fructose-1,6-bisphosphatase I 3.1.3.11 ko00010 Glycolysis / Gluconeogenesis ko00030 Pentose phosphate pathway ko00051 Fructose and mannose metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko04152 AMPK signaling pathway ko04910 Insulin signaling pathway Fructose-1,6-bisphosphatase G Carbohydrate transport and metabolism ; IPR033391 [Fructose-1-6-bisphosphatase class I, N-terminal] -- -- Q5SW18 Platelet-activating factor acetylhydrolase IB subunit alpha Pafah1b1 4902.6 4812.5 4019.1 3949.2 3883.9 4319.3 1.13016358908528 0.165999530524449 0.176531615189413 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) platelet-activating factor acetylhydrolase IB subunit alpha -- ko00565 Ether lipid metabolism ko01100 Metabolic pathways WD40 repeat-containing protein S Function unknown ; IPR001680 [WD40 repeat] ; IPR006594[LIS1 homology motif] -- -- Q9DB05 Alpha-soluble NSF attachment protein Napa 4080.7 4088.9 3714.7 3787.4 3798 3906.3 1.03416378777727 0.368083712928433 0.0484646934875843 Nonsignificant None -- -- alpha-soluble NSF attachment protein -- ko04721 Synaptic vesicle cycle Protein required for fusion of vesicles in vesicular transport, alpha-SNAP U Intracellular trafficking, secretion, and vesicular transport ; -- -- -- Q8K354 Carbonyl reductase [NADPH] 3 Cbr3 2779.3 2570.2 2418.4 3498.2 3667.9 4016.8 0.694623040535103 0.00354391225796754 -0.525697829410036 Nonsignificant None -- -- carbonyl reductase 3 1.1.1.184 ko00590 Arachidonic acid metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko01100 Metabolic pathways Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Q Secondary metabolites biosynthesis, transport and catabolism ; IPR002347 [Short-chain dehydrogenase/reductase SDR] -- -- Q3ULW0 GTP-binding nuclear protein Ran Ran 9076.7 8983.5 7621.4 6751.6 6873.8 6568 1.27178186932364 0.0187472601963306 0.346851246855619 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) GTP-binding nuclear protein Ran -- ko03008 Ribosome biogenesis in eukaryotes ko03013 RNA transport ko05166 HTLV-I infection ko05169 Epstein-Barr virus infection GTPase Ran/TC4/GSP1 (nuclear protein transport pathway), small G protein superfamily U Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- G3X922 DnaJ heat shock protein family (Hsp40) member C13 Dnajc13 3195.8 3287.7 3436.1 3110.3 3274.5 3260.5 1.02843872144983 0.355215402844026 0.0404558348018851 Nonsignificant None -- -- DnaJ homolog subfamily C member 13 -- -- Endocytosis protein RME-8, contains DnaJ domain UO Intracellular trafficking, secretion, and vesicular transport ; Posttranslational modification, protein turnover, chaperones ; IPR001623 [DnaJ domain] ; IPR025640[Domain of unknown function DUF4339] -- -- P35278 Ras-related protein Rab-5C Rab5c 1231.7 1300.3 1324.9 1418.6 1482.7 1388.4 0.899107163671119 0.0215105683073545 -0.15343501554036 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-5C -- ko04014 Ras signaling pathway ko04144 Endocytosis ko04145 Phagosome ko04962 Vasopressin-regulated water reabsorption ko05146 Amoebiasis ko05152 Tuberculosis GTPase Rab5/YPT51 and related small G protein superfamily GTPases U Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- Q6ZQ61 MKIAA0723 protein (Fragment) Matr3 5137.6 5230.5 5832.5 5075.6 5091.2 5001.9 1.06802824236751 0.253912894258906 0.0949497973857843 Nonsignificant None -- -- matrin 3 -- -- -- -- -- -- -- -- Q3UNM2 Uncharacterized protein (Fragment) Numa1 113.8 111.2 116.5 139 141.3 122.4 0.848025825676682 0.0294184044980804 -0.237819893768301 Nonsignificant None -- -- nuclear mitotic apparatus protein 1 -- -- -- -- -- -- -- -- Q8BQK0 Uncharacterized protein Asph 3402.8 3336.9 4091.1 3826.3 3791.4 4024.1 0.930337233073923 0.343480172040598 -0.104174328888349 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Cellular Component:membrane (GO:0016020),Biological Process:peptidyl-amino acid modification (GO:0018193) aspartate beta-hydroxylase 1.14.11.16 -- Aspartyl beta-hydroxylase O Posttranslational modification, protein turnover, chaperones ; IPR007803 [Aspartyl/asparaginy/proline hydroxylase] ; IPR007943[Aspartyl beta-hydroxylase/Triadin domain] ; IPR019734[Tetratricopeptide repeat] -- -- Q8BX02 KN motif and ankyrin repeat domain-containing protein 2 Kank2 2725.1 2777.9 3075.9 3520.4 3401.3 3340.3 0.835987137010329 0.00985234252434632 -0.258447350564668 Nonsignificant None -- -- -- -- -- Ankyrin repeat protein R General function prediction only ; IPR020683 [Ankyrin repeat-containing domain] ; IPR021939[Kank N-terminal motif] -- -- Q8CBB7 AP-1 complex subunit gamma Ap1g1 3526.7 3505.6 3868.5 4061.4 4078.6 4079 0.892118831328259 0.0644171542117002 -0.164692203183889 Nonsignificant None 4 Biological Process:intracellular protein transport (GO:0006886),Biological Process:vesicle-mediated transport (GO:0016192),Cellular Component:membrane coat (GO:0030117),Cellular Component:clathrin adaptor complex (GO:0030131) AP-1 complex subunit gamma-1 -- ko04142 Lysosome Vesicle coat complex AP-1, gamma subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR002553 [Clathrin/coatomer adaptor, adaptin-like, N-terminal] ; IPR008152[Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain] -- -- Q922A2 Annexin Anxa7 6098.2 5867.9 5517.6 5923.1 6043 6436.6 0.950061675732365 0.252382744399315 -0.0739069220911419 Nonsignificant None 2 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:calcium-dependent phospholipid binding (GO:0005544) annexin A7/11 -- -- Annexin U Intracellular trafficking, secretion, and vesicular transport ; IPR018502 [Annexin repeat] -- -- G5E8G6 Unconventional myosin-Vb Myo5b 2532.4 2353.9 2842.6 2947.1 3123.3 3080 0.844651599930058 0.0358285450402712 -0.243571710536105 Nonsignificant None 4 Molecular Function:motor activity (GO:0003774),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Cellular Component:myosin complex (GO:0016459) myosin V -- -- Myosin class V heavy chain Z Cytoskeleton ; IPR000048 [IQ motif, EF-hand binding site] ; IPR001609[Myosin head, motor domain] ; IPR002710[Dilute domain] -- -- Q91VH2 Sorting nexin-9 Snx9 2851.5 2780.3 2803 3015.9 2906.1 3005.2 0.944842727842997 0.0157956809910352 -0.0818538868697378 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:phosphatidylinositol binding (GO:0035091) sorting nexin-9/18/33 -- -- Sorting nexin SNX9/SH3PX1 and related proteins U Intracellular trafficking, secretion, and vesicular transport ; IPR001452 [SH3 domain] ; IPR001683[Phox homologous domain] ; IPR019497[Sorting nexin protein, WASP-binding domain] -- -- D3YYE1 Acidic leucine-rich nuclear phosphoprotein 32 family member A (Fragment) Anp32a 3002.5 2858.1 2851.7 2765.3 2905 2910.8 1.01528941510995 0.557667831157545 0.0218910360087285 Nonsignificant None -- -- acidic leucine-rich nuclear phosphoprotein 32 family member A/C/D -- -- Leucine-rich acidic nuclear protein DR Cell cycle control, cell division, chromosome partitioning ; General function prediction only ; -- -- -- Q99JZ4 GTP-binding protein SAR1a Sar1a 2277 2188.9 2116.2 2224.8 2195.3 2170.2 0.998755747082834 0.958270786770123 -0.00179619520564777 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) GTP-binding protein SAR1 3.6.5.- ko04141 Protein processing in endoplasmic reticulum ko05134 Legionellosis Vesicle coat complex COPII, GTPase subunit SAR1 U Intracellular trafficking, secretion, and vesicular transport ; IPR006689 [Small GTPase superfamily, ARF/SAR type] -- -- P57759 Endoplasmic reticulum resident protein 29 Erp29 4395.9 4439.7 4982.1 4414.3 4793.3 4603.1 1.0005068533818 0.991971622750141 0.000731049608541226 Nonsignificant None 3 Cellular Component:endoplasmic reticulum (GO:0005783),Cellular Component:endoplasmic reticulum lumen (GO:0005788),Biological Process:protein secretion (GO:0009306) endoplasmic reticulum protein 29 -- ko04141 Protein processing in endoplasmic reticulum -- -- -- IPR011679 [Endoplasmic reticulum, protein ERp29, C-terminal] ; IPR012883[ERp29, N-terminal] -- -- Q3UVN0 RNA helicase Ddx39a 1506.6 1526.8 1428.4 1391.7 1465.4 1304 1.0722645454327 0.145039367737148 0.100660886485281 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase DDX39 3.6.4.13 -- ATP-dependent RNA helicase A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR011545[DEAD/DEAH box helicase domain] -- -- Q61081 Hsp90 co-chaperone Cdc37 Cdc37 6039 5892.2 5600.9 5667.4 5897.8 5491.4 1.02787777165437 0.414878155512042 0.0396687190919509 Nonsignificant None 1 Molecular Function:protein kinase binding (GO:0019901) cell division cycle protein 37 -- ko04151 PI3K-Akt signaling pathway Cell division cycle 37 protein, CDC37 D Cell cycle control, cell division, chromosome partitioning ; IPR013855 [Cdc37, N-terminal domain] ; IPR013873[Cdc37, C-terminal] ; IPR013874[Cdc37, Hsp90 binding] -- -- Q9QUM9 Proteasome subunit alpha type-6 Psma6 7524 7336.2 7585.4 6894.3 6957.3 7250.2 1.06368177122331 0.027982456645634 0.0890665946847617 Nonsignificant None 5 Molecular Function:endopeptidase activity (GO:0004175),Molecular Function:threonine-type endopeptidase activity (GO:0004298),Cellular Component:proteasome core complex (GO:0005839),Biological Process:ubiquitin-dependent protein catabolic process (GO:0006511),Biological Process:proteolysis involved in cellular protein catabolic process (GO:0051603) 20S proteasome subunit alpha 1 3.4.25.1 ko03050 Proteasome 20S proteasome, regulatory subunit alpha type PSMA6/SCL1 O Posttranslational modification, protein turnover, chaperones ; IPR000426 [Proteasome alpha-subunit, N-terminal domain] ; IPR001353[Proteasome, subunit alpha/beta] -- -- Q64442 Sorbitol dehydrogenase Sord 3955.4 3895.3 4831 5753.5 5673.9 5796.8 0.736272221641644 0.0360357000944369 -0.441688822897197 Nonsignificant None 1 Biological Process:oxidation-reduction process (GO:0055114) L-iditol 2-dehydrogenase 1.1.1.14 ko00040 Pentose and glucuronate interconversions ko00051 Fructose and mannose metabolism ko01100 Metabolic pathways Sorbitol dehydrogenase Q Secondary metabolites biosynthesis, transport and catabolism ; IPR013149 [Alcohol dehydrogenase, C-terminal] ; IPR013154[Alcohol dehydrogenase, N-terminal] -- -- G3X8Y3 N-alpha-acetyltransferase 15, NatA auxiliary subunit Naa15 3705.7 3794.2 3579.5 3206.6 3300.8 3210.2 1.14013748250597 0.00283906356850057 0.189207801030752 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) N-alpha-acetyltransferase 15/16, NatA auxiliary subunit -- -- N-terminal acetyltransferase B Chromatin structure and dynamics ; IPR019734 [Tetratricopeptide repeat] ; IPR021183[N-terminal acetyltransferase A, auxiliary subunit] -- -- Q3TJ91 LLGL scribble cell polarity complex component 2 Llgl2 2143.8 1946.6 1776 2200.5 2287.9 2326.9 0.860769151761478 0.0484202301449682 -0.216301719360628 Nonsignificant None -- -- lethal(2) giant larvae protein -- ko04390 Hippo signaling pathway ko04530 Tight junction ko05165 Human papillomavirus infection Tomosyn and related SNARE-interacting proteins U Intracellular trafficking, secretion, and vesicular transport ; IPR013577 [Lethal giant larvae homologue 2] -- -- Q3TB15 Uncharacterized protein Appl2 2558.1 2373.7 2428.8 2705.1 2720.3 2799.6 0.894905775075988 0.00968469575953069 -0.160192306350489 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) DCC-interacting protein 13-beta -- -- Putative GTPase activating proteins (GAPs) T Signal transduction mechanisms ; IPR001849 [Pleckstrin homology domain] ; IPR006020[PTB/PI domain] -- -- O35685 Nuclear migration protein nudC Nudc 5497.1 5428.7 4831 4078.7 4173.2 4073.8 1.27836958550022 0.0301293071265858 0.354304989716151 Nonsignificant None -- -- -- -- -- Nuclear distribution protein NUDC T Signal transduction mechanisms ; IPR007052 [CS domain] ; IPR025934[NudC N-terminal domain] ; IPR032572[Nuclear migration protein nudC] -- -- Q61576 Peptidyl-prolyl cis-trans isomerase FKBP10 Fkbp10 3670.4 3668.8 3744.6 3496.8 3591.4 3461.8 1.0505971563981 0.0181284022133913 0.0712095847357565 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) FK506-binding protein 9/10 5.2.1.8 -- FKBP-type peptidyl-prolyl cis-trans isomerase O Posttranslational modification, protein turnover, chaperones ; IPR001179 [FKBP-type peptidyl-prolyl cis-trans isomerase domain] ; IPR002048[EF-hand domain] -- -- Q8QZS1 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Hibch 3847.5 3791.8 3913.9 4502 4323 4487 0.867878605769231 0.00095756134809455 -0.204434834593894 Nonsignificant None 1 Molecular Function:3-hydroxyisobutyryl-CoA hydrolase activity (GO:0003860) 3-hydroxyisobutyryl-CoA hydrolase 3.1.2.4 ko00280 Valine, leucine and isoleucine degradation ko00410 beta-Alanine metabolism ko00640 Propanoate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism Enoyl-CoA hydratase I Lipid transport and metabolism ; IPR032259 [Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type] -- -- Q9JIX8 Apoptotic chromatin condensation inducer in the nucleus Acin1 131.6 113.5 113.7 125.6 125.5 133.1 0.933888599687663 0.263074864817818 -0.0986776287462659 Nonsignificant None -- -- apoptotic chromatin condensation inducer in the nucleus -- ko03013 RNA transport ko03015 mRNA surveillance pathway ko03040 Spliceosome Acinus (induces apoptotic chromatin condensation) B Chromatin structure and dynamics ; IPR003034 [SAP domain] ; IPR032552[Acin1, RNSP1-SAP18 binding (RSB) motif] -- -- P97363 Serine palmitoyltransferase 2 Sptlc2 2523.7 2522.6 2832.2 2275.6 2574.4 2413.9 1.08461019562494 0.202143117815568 0.117176637247434 Nonsignificant None 2 Biological Process:biosynthetic process (GO:0009058),Molecular Function:pyridoxal phosphate binding (GO:0030170) serine palmitoyltransferase 2.3.1.50 ko00600 Sphingolipid metabolism ko01100 Metabolic pathways ko04071 Sphingolipid signaling pathway Serine palmitoyltransferase O Posttranslational modification, protein turnover, chaperones ; IPR004839 [Aminotransferase, class I/classII] -- -- A0A6I8MX27 L-lactate dehydrogenase Ldhb 2399.6 2491.8 2968.7 3356.4 3012.1 3339.3 0.80966851397845 0.04205590829004 -0.304596719140327 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) L-lactate dehydrogenase 1.1.1.27 ko00010 Glycolysis / Gluconeogenesis ko00270 Cysteine and methionine metabolism ko00620 Pyruvate metabolism ko00640 Propanoate metabolism ko01100 Metabolic pathways ko04922 Glucagon signaling pathway Lactate dehydrogenase C Energy production and conversion ; IPR001236 [Lactate/malate dehydrogenase, N-terminal] ; IPR022383[Lactate/malate dehydrogenase, C-terminal] -- -- Q6NXL1 Sec24-related gene family, member D (S. cerevisiae) Sec24d 4960 4642.9 4779.3 4594 4767.5 4664.5 1.02539569371168 0.320321986312165 0.0361807440670273 Nonsignificant None 4 Biological Process:intracellular protein transport (GO:0006886),Biological Process:ER to Golgi vesicle-mediated transport (GO:0006888),Molecular Function:zinc ion binding (GO:0008270),Cellular Component:COPII vesicle coat (GO:0030127) protein transport protein SEC24 -- ko04141 Protein processing in endoplasmic reticulum Vesicle coat complex COPII, subunit SFB3 U Intracellular trafficking, secretion, and vesicular transport ; IPR006895 [Zinc finger, Sec23/Sec24-type] ; IPR006896[Sec23/Sec24, trunk domain] ; IPR006900[Sec23/Sec24, helical domain] ; IPR007123[Gelsolin-like domain] ; IPR012990[Sec23/Sec24 beta-sandwich] -- -- Q66JR8 Ptms protein Ptms 3679.9 3804.8 3874.6 4711.2 4742.1 4750.6 0.799731059779356 0.000083035179533544 -0.322413174831146 Nonsignificant None -- -- translation initiation factor 5A -- -- Translation initiation factor 5A (eIF-5A) J Translation, ribosomal structure and biogenesis ; IPR004931 [Prothymosin/parathymosin] -- -- A0A0R4J0I1 Serine protease inhibitor A3K Serpina3k 227.6 216.4 171.2 159.6 219.9 119.7 1.23237179487179 0.316989046801634 0.301437569099578 Nonsignificant None -- -- serpin peptidase inhibitor, clade A -- -- Serpin V Defense mechanisms ; IPR023796 [Serpin domain] -- -- Q8K232 Adducin 1 (Alpha) Add1 4021.3 3906.2 3399.3 3675.7 3732.3 3820.8 1.00872755770875 0.875511662433875 0.0125365766084242 Nonsignificant None -- -- adducin -- -- Cytoskeletal protein Adducin TZ Signal transduction mechanisms ; Cytoskeleton ; IPR001303 [Class II aldolase/adducin N-terminal] -- -- Q7TPW6 Solute carrier family 25 (Mitochondrial carnitine/acylcarnitine translocase), member 20 Slc25a20 3366.2 3154.1 4422.2 4048.2 3863.7 3958.8 0.921807475549041 0.513661495962983 -0.117462627393102 Nonsignificant None -- -- solute carrier family 25 (mitochondrial carnitine/acylcarnitine transporter), member 20/29 -- -- Mitochondrial carnitine-acylcarnitine carrier protein C Energy production and conversion ; IPR018108 [Mitochondrial substrate/solute carrier] -- -- P47857 ATP-dependent 6-phosphofructokinase, muscle type Pfkm 683.2 660.4 655 716.2 676.6 803.6 0.90994354398106 0.161953546631594 -0.136151056548757 Nonsignificant None 2 Molecular Function:6-phosphofructokinase activity (GO:0003872),Biological Process:glycolytic process (GO:0006096) 6-phosphofructokinase 1 2.7.1.11 ko00010 Glycolysis / Gluconeogenesis ko00030 Pentose phosphate pathway ko00051 Fructose and mannose metabolism ko00052 Galactose metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids ko03018 RNA degradation ko04152 AMPK signaling pathway ko05230 Central carbon metabolism in cancer Pyrophosphate-dependent phosphofructo-1-kinase G Carbohydrate transport and metabolism ; IPR000023 [Phosphofructokinase domain] -- -- P00329 Alcohol dehydrogenase 1 Adh1 4630.4 3713.3 2780 6389.5 6374.4 8944.2 0.512421630635569 0.0248447470418813 -0.964596718052443 Significant down 1 Biological Process:oxidation-reduction process (GO:0055114) alcohol dehydrogenase 1/7 1.1.1.1 ko00010 Glycolysis / Gluconeogenesis ko00071 Fatty acid degradation ko00350 Tyrosine metabolism ko00830 Retinol metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko01100 Metabolic pathways ko05204 Chemical carcinogenesis Alcohol dehydrogenase, class III Q Secondary metabolites biosynthesis, transport and catabolism ; IPR013149 [Alcohol dehydrogenase, C-terminal] ; IPR013154[Alcohol dehydrogenase, N-terminal] -- -- Q91Y97 Fructose-bisphosphate aldolase B Aldob 2592.3 2381.5 4155.1 4900.3 4164.5 4484.8 0.673739446182913 0.0695547359496089 -0.569737325996359 Nonsignificant None 2 Molecular Function:fructose-bisphosphate aldolase activity (GO:0004332),Biological Process:glycolytic process (GO:0006096) fructose-bisphosphate aldolase, class I 4.1.2.13 ko00010 Glycolysis / Gluconeogenesis ko00030 Pentose phosphate pathway ko00051 Fructose and mannose metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids Fructose-biphosphate aldolase G Carbohydrate transport and metabolism ; IPR000741 [Fructose-bisphosphate aldolase, class-I] -- -- P54823 Probable ATP-dependent RNA helicase DDX6 Ddx6 2512.4 2577.9 2336.2 2151.7 2131.1 2211.1 1.14361169713115 0.0150046846376017 0.193597281383507 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase DDX6/DHH1 3.6.4.13 ko03018 RNA degradation ATP-dependent RNA helicase A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR011545[DEAD/DEAH box helicase domain] -- -- Q9CQ65 S-methyl-5-thioadenosine phosphorylase Mtap 3700.8 3647 3077.8 2920.2 2929.7 2932.1 1.18715554543384 0.11073039850582 0.247508974511614 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:nucleoside metabolic process (GO:0009116) 5'-methylthioadenosine phosphorylase 2.4.2.28 ko00270 Cysteine and methionine metabolism ko01100 Metabolic pathways Methylthioadenosine phosphorylase MTAP F Nucleotide transport and metabolism ; IPR000845 [Nucleoside phosphorylase domain] -- -- Q99JR1 Sideroflexin-1 Sfxn1 1735.5 1629.5 1729.6 1973.4 1966.6 1890.1 0.87384435944495 0.00489511188121207 -0.194551750919312 Nonsignificant None 4 Biological Process:ion transport (GO:0006811),Molecular Function:ion transmembrane transporter activity (GO:0015075),Cellular Component:membrane (GO:0016020),Biological Process:transmembrane transport (GO:0055085) -- -- -- Sideroflexin R General function prediction only ; IPR004686 [Tricarboxylate/iron carrier] -- -- P49718 DNA replication licensing factor MCM5 Mcm5 3174.8 3071.9 3078.1 2676.2 2675.2 2744.3 1.15182133725311 0.000532749756652733 0.203916953022786 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Molecular Function:ATP binding (GO:0005524),Biological Process:DNA replication (GO:0006260) DNA replication licensing factor MCM5 3.6.4.12 ko03030 DNA replication ko04110 Cell cycle DNA replication licensing factor, MCM5 component L Replication, recombination and repair ; IPR001208 [MCM domain] ; IPR027925[MCM N-terminal domain] ; IPR033762[MCM OB domain] -- -- Q3UCF2 Uncharacterized protein Cdc5l 3161.8 3242.4 3095.1 2855.9 2835.1 2755.8 1.12460340010418 0.00258487757305889 0.169416313814248 Nonsignificant None -- -- pre-mRNA-splicing factor CDC5/CEF1 -- ko03040 Spliceosome mRNA splicing protein CDC5 (Myb superfamily) AD RNA processing and modification ; Cell cycle control, cell division, chromosome partitioning ; IPR021786 [Pre-mRNA splicing factor component Cdc5p/Cef1] -- MYB Q06138 Calcium-binding protein 39 Cab39 3648.7 3931.3 4504.9 4161.7 4129.6 3954.7 0.986844683978442 0.846434470278694 -0.0191050530488815 Nonsignificant None -- -- calcium binding protein 39 -- ko04150 mTOR signaling pathway ko04152 AMPK signaling pathway Conserved protein Mo25 S Function unknown ; IPR013878 [Mo25-like] -- -- A0A0R4J050 N-acyl-aliphatic-L-amino acid amidohydrolase Acy1 61.4 60 55.2 49 63.3 58.9 1.03154205607477 0.717059849268764 0.044802641247319 Nonsignificant None 2 Biological Process:metabolic process (GO:0008152),Molecular Function:hydrolase activity (GO:0016787) aminoacylase 3.5.1.14 ko00220 Arginine biosynthesis ko01100 Metabolic pathways ko01210 2-Oxocarboxylic acid metabolism ko01230 Biosynthesis of amino acids Aminoacylase ACY1 and related metalloexopeptidases E Amino acid transport and metabolism ; IPR002933 [Peptidase M20] ; IPR011650[Peptidase M20, dimerisation domain] -- -- Q8BFZ9 Erlin-2 Erlin2 1939.1 1896.1 2516.2 2778.8 2682 2682.7 0.7799349174188 0.0419636439607223 -0.358574353264523 Nonsignificant None -- -- -- -- -- Prohibitin-related membrane protease subunits R General function prediction only ; IPR001107 [Band 7 domain] -- -- O08599 Syntaxin-binding protein 1 Stxbp1 1734.3 1663.2 1864.5 2243.1 2153.2 2193.5 0.798506783210416 0.00235057351621298 -0.324623431693606 Nonsignificant None 2 Biological Process:vesicle docking involved in exocytosis (GO:0006904),Biological Process:vesicle-mediated transport (GO:0016192) syntaxin-binding protein 1 -- ko04721 Synaptic vesicle cycle Vesicle trafficking protein Sec1 U Intracellular trafficking, secretion, and vesicular transport ; IPR001619 [Sec1-like protein] -- -- Q543J5 Antithrombin-III Serpinc1 7726 5219.5 3197.9 3053.5 3105.8 3014.9 1.75965206775523 0.218052135270472 0.815290196052015 Nonsignificant None -- -- antithrombin III -- ko04610 Complement and coagulation cascades Serpin V Defense mechanisms ; IPR023796 [Serpin domain] -- -- P20108 Thioredoxin-dependent peroxide reductase, mitochondrial Prdx3 4275.3 4316.6 5078.5 5211.3 4766.6 4980.3 0.913906753486382 0.21418308138228 -0.129881121229232 Nonsignificant None 4 Molecular Function:antioxidant activity (GO:0016209),Molecular Function:oxidoreductase activity (GO:0016491),Molecular Function:peroxiredoxin activity (GO:0051920),Biological Process:oxidation-reduction process (GO:0055114) peroxiredoxin 3 1.11.1.15 -- Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes O Posttranslational modification, protein turnover, chaperones ; IPR000866 [Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant] ; IPR019479[Peroxiredoxin, C-terminal] -- -- Q923D2 Flavin reductase (NADPH) Blvrb 1598.4 1580.2 1469.9 2086.6 2059 2010.2 0.755141492576107 0.000397007153293884 -0.405181104075517 Nonsignificant None -- -- -- -- ko00740 Riboflavin metabolism ko00860 Porphyrin and chlorophyll metabolism ko01100 Metabolic pathways -- -- -- IPR016040 [NAD(P)-binding domain] -- -- F6TFN2 LIM domain only 7 (Fragment) Lmo7 4130.8 3910.7 3678.1 3773.6 3742.4 3561.6 1.05795479165162 0.217763848806788 0.0812779797643037 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:zinc ion binding (GO:0008270) F-box protein 20 -- ko04520 Adherens junction -- -- -- IPR001478 [PDZ domain] ; IPR001781[Zinc finger, LIM-type] ; IPR031865[Domain of unknown function DUF4757] -- -- Q99J57 S-adenosylmethionine synthase Mat2a 5159 4917.3 5440.4 5598.4 5588 5581.9 0.925359159843276 0.109870204667489 -0.111914667036404 Nonsignificant None 2 Molecular Function:methionine adenosyltransferase activity (GO:0004478),Biological Process:S-adenosylmethionine biosynthetic process (GO:0006556) S-adenosylmethionine synthetase 2.5.1.6 ko00270 Cysteine and methionine metabolism ko01100 Metabolic pathways ko01230 Biosynthesis of amino acids S-adenosylmethionine synthetase H Coenzyme transport and metabolism ; IPR022628 [S-adenosylmethionine synthetase, N-terminal] ; IPR022629[S-adenosylmethionine synthetase, central domain] ; IPR022630[S-adenosylmethionine synthetase, C-terminal] -- -- Q99MQ4 Asporin Aspn 3915.8 4089.3 4605.7 6043.5 5974.4 5760.2 0.709344643128343 0.00154015538650754 -0.495441347360769 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) asporin -- -- FOG: Leucine rich repeat R General function prediction only ; IPR000372 [Leucine-rich repeat N-terminal domain] ; IPR001611[Leucine-rich repeat] -- -- Q9D020 Cytosolic 5-nucleotidase 3A Nt5c3a 2898.6 2652.5 2732.7 3630.5 3874.4 3310 0.765961774958622 0.00917566667123269 -0.384655698107441 Nonsignificant None 3 Molecular Function:magnesium ion binding (GO:0000287),Cellular Component:cytoplasm (GO:0005737),Molecular Function:5'-nucleotidase activity (GO:0008253) 5'-nucleotidase 3.1.3.5 ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko00760 Nicotinate and nicotinamide metabolism ko01100 Metabolic pathways Uncharacterized conserved protein S Function unknown ; IPR006434 [Pyrimidine 5'-nucleotidase, eukaryotic] -- -- Q61703 Inter-alpha-trypsin inhibitor heavy chain H2 Itih2 5348 5480.8 4180.9 3460.6 3639.6 3297.4 1.44357351696545 0.0223440689283114 0.529644581672064 Nonsignificant None 2 Molecular Function:serine-type endopeptidase inhibitor activity (GO:0004867),Biological Process:hyaluronan metabolic process (GO:0030212) inter-alpha-trypsin inhibitor heavy chain H2 -- -- -- -- -- IPR002035 [von Willebrand factor, type A] ; IPR010600[Inter-alpha-trypsin inhibitor heavy chain, C-terminal] ; IPR013694[VIT domain] -- -- A0A0F7QZE4 MAb 110 heavy chain HC 3303.8 3522.2 2973.7 1637.8 1669.3 1772.1 1.92937864230587 0.000667418320955053 0.948136301381268 Significant up -- -- -- -- -- -- -- -- IPR003597 [Immunoglobulin C1-set] ; IPR013106[Immunoglobulin V-set domain] -- -- Q3TDD8 RRM domain-containing protein Eif4b 6700.6 6901.1 5839.6 5383.7 5703.5 5393 1.17967621752163 0.0447925737143664 0.238390941388398 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) translation initiation factor 4B -- ko03013 RNA transport ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko05205 Proteoglycans in cancer FOG: RRM domain R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- Q3UA13 Eukaryotic translation initiation factor 6 Eif6 2390.1 2336.2 1857.3 1954.1 2056.4 2100.2 1.07738884252213 0.418105921473465 0.107539029764923 Nonsignificant None 2 Biological Process:mature ribosome assembly (GO:0042256),Molecular Function:ribosome binding (GO:0043022) translation initiation factor 6 -- ko03008 Ribosome biogenesis in eukaryotes Translation initiation factor 6 (eIF-6) J Translation, ribosomal structure and biogenesis ; IPR002769 [Translation initiation factor IF6] -- -- Q9Z1F9 SUMO-activating enzyme subunit 2 Uba2 4138.8 4381.1 4833.5 4455.2 4520.4 4508.5 0.990307102439169 0.850749179692842 -0.0140521086230014 Nonsignificant None 1 Molecular Function:small protein activating enzyme activity (GO:0008641) ubiquitin-like 1-activating enzyme E1 B 6.2.1.45 ko04120 Ubiquitin mediated proteolysis SMT3/SUMO-activating complex, catalytic component UBA2 O Posttranslational modification, protein turnover, chaperones ; IPR000594 [THIF-type NAD/FAD binding fold] ; IPR028077[Ubiquitin/SUMO-activating enzyme ubiquitin-like domain] ; IPR032426[SUMO-activating enzyme subunit 2, C-terminal domain] -- -- Q9EPC1 Alpha-parvin Parva 3921.2 3980.7 3482.5 3678.6 3576.3 3735.1 1.03588717015469 0.46723565871722 0.0508668718246557 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) parvin -- ko04510 Focal adhesion Alpha-parvin and related focal adhesion proteins Z Cytoskeleton ; IPR001715 [Calponin homology domain] -- -- P35293 Ras-related protein Rab-18 Rab18 3501.3 3397.4 3363.5 3445.9 3469.7 3428.3 0.992101625112385 0.562269870780193 -0.0114401854281686 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-18 -- -- GTPase Rab18, small G protein superfamily R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- A2NHM3 If kappa light chain (Fragment) Igkc 62.4 62.1 45.3 51.5 57.4 59.3 1.00951248513674 0.934735079948632 0.0136587532978944 Nonsignificant None -- -- immunoglobulin lambda-like polypeptide 1 -- -- -- -- -- IPR003597 [Immunoglobulin C1-set] ; IPR013106[Immunoglobulin V-set domain] -- -- Q9DCL9 Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase Paics 4873.7 4867.7 4526.6 4220.8 4346.7 4328.4 1.10639815755395 0.0195688426710943 0.145870659133591 Nonsignificant None 1 Biological Process:'de novo' IMP biosynthetic process (GO:0006189) -- -- ko00230 Purine metabolism ko01100 Metabolic pathways Phosphoribosylamidoimidazole-succinocarboxamide synthase F Nucleotide transport and metabolism ; IPR000031 [PurE domain] ; IPR028923[SAICAR synthetase/ADE2, N-terminal] -- -- Q9DAR7 m7GpppX diphosphatase Dcps 3207.5 3112.8 2859.4 3220.4 3273.6 3105.4 0.956278517407338 0.291224968138557 -0.0644972286039259 Nonsignificant None 2 Biological Process:deadenylation-dependent decapping of nuclear-transcribed mRNA (GO:0000290),Molecular Function:hydrolase activity (GO:0016787) m7GpppX diphosphatase 3.6.1.59 ko03018 RNA degradation Uncharacterized conserved protein S Function unknown ; IPR008594 [Scavenger mRNA decapping enzyme DcpS/DCS2] -- -- Q8R3B1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Plcd1 1745.5 1769.6 1869.7 2094.1 2128.9 2092.5 0.852632412318898 0.00146631946197069 -0.230004195340933 Nonsignificant None 5 Molecular Function:phosphatidylinositol phospholipase C activity (GO:0004435),Molecular Function:protein binding (GO:0005515),Biological Process:lipid metabolic process (GO:0006629),Biological Process:signal transduction (GO:0007165),Biological Process:intracellular signal transduction (GO:0035556) phosphatidylinositol phospholipase C, delta 3.1.4.11 ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04020 Calcium signaling pathway ko04070 Phosphatidylinositol signaling system ko04919 Thyroid hormone signaling pathway ko04933 AGE-RAGE signaling pathway in diabetic complications Phosphoinositide-specific phospholipase C T Signal transduction mechanisms ; IPR000008 [C2 domain] ; IPR000909[Phosphatidylinositol-specific phospholipase C, X domain] ; IPR001711[Phospholipase C, phosphatidylinositol-specific, Y domain] ; IPR001849[Pleckstrin homology domain] ; IPR015359[Phosphoinositide-specific phospholipase C, EF-hand-like domain] -- -- Q543N3 LIM and SH3 domain protein 1 Lasp1 4300 4611.3 4210.1 4446.9 4531.8 3868.7 1.02132727244423 0.72417711367566 0.0304452351442621 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:zinc ion binding (GO:0008270) -- -- -- Nebulin repeat protein Z Cytoskeleton ; IPR000900 [Nebulin repeat] ; IPR001452[SH3 domain] ; IPR001781[Zinc finger, LIM-type] -- -- Q61646 Haptoglobin Hp 8806.4 9035.7 7144.1 3133.9 3127.9 3105.4 2.66741395507729 0.0128387703225347 1.4154417336231 Significant up 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) haptoglobin -- -- Trypsin E Amino acid transport and metabolism ; IPR001254 [Serine proteases, trypsin domain] -- -- Q9QYG0 Protein NDRG2 Ndrg2 3726.4 3368.9 3433 4966.9 4962.2 5311.1 0.690824267398066 0.00059725965765209 -0.533609331881685 Nonsignificant None -- -- -- -- -- Differentiation-related gene 1 protein (NDR1 protein), related proteins S Function unknown ; IPR004142 [NDRG] -- -- Q61191 Host cell factor 1 Hcfc1 3033.2 3141.8 3077.8 2755.8 2733.2 2654.8 1.13617721456814 0.00109179225600135 0.184187875897936 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) host cell factor -- ko05168 Herpes simplex infection Host cell transcription factor HCFC1 DK Cell cycle control, cell division, chromosome partitioning ; Transcription ; IPR006652 [Kelch repeat type 1] -- -- Q9QWG7 Sulfotransferase 1B1 Sult1b1 4549.9 4050.3 4544.7 6392.6 6354.5 6334 0.688896342454051 0.00648217404730611 -0.537641176512168 Nonsignificant None 1 Molecular Function:sulfotransferase activity (GO:0008146) sulfotransferase 2.8.2.- -- Sulfotransferase R General function prediction only ; IPR000863 [Sulfotransferase domain] -- -- Q3UDE2 Tubulin--tyrosine ligase-like protein 12 Ttll12 1847.1 1844.4 1911.2 1824.6 1924.1 1849.9 1.00073232593863 0.972295233747964 0.00105613632914112 Nonsignificant None 1 Biological Process:cellular protein modification process (GO:0006464) tubulin--tyrosine ligase-like protein 12 -- -- Tubulin-tyrosine ligase-related protein O Posttranslational modification, protein turnover, chaperones ; IPR004344 [Tubulin-tyrosine ligase/Tubulin polyglutamylase] -- -- Q545N8 Phosphomannomutase Pmm2 5377.6 4869.3 4957.1 5173.3 5301.5 5146.5 0.973286474237099 0.444093743787951 -0.0390635888211254 Nonsignificant None 3 Molecular Function:phosphomannomutase activity (GO:0004615),Cellular Component:cytoplasm (GO:0005737),Biological Process:GDP-mannose biosynthetic process (GO:0009298) phosphomannomutase 5.4.2.8 ko00051 Fructose and mannose metabolism ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways Phosphomannomutase I Lipid transport and metabolism ; IPR005002 [Phosphomannomutase] -- -- F8WHU5 Sister chromatid cohesion protein PDS5 homolog B Pds5b 1937.2 1890 2075.2 1885.1 1847 1978.1 1.03365906623236 0.398495523488098 0.047760417216608 Nonsignificant None -- -- sister chromatid cohesion protein PDS5 -- -- Sister chromatid cohesion complex Cohesin, subunit PDS5 D Cell cycle control, cell division, chromosome partitioning ; -- -- -- Q9CXT8 Mitochondrial-processing peptidase subunit beta Pmpcb 1985.7 1839.1 1915 1697.8 1740.3 1744.6 1.10749223377776 0.0144100790065689 0.147296582004135 Nonsignificant None -- -- mitochondrial-processing peptidase subunit beta 3.4.24.64 -- Mitochondrial processing peptidase, beta subunit, and related enzymes (insulinase superfamily) O Posttranslational modification, protein turnover, chaperones ; IPR007863 [Peptidase M16, C-terminal] ; IPR011765[Peptidase M16, N-terminal] -- -- E9PVX6 Proliferation marker protein Ki-67 Mki67 3457.2 3451.7 3036.6 2547.8 2642.8 2516.3 1.2904669841311 0.00666106743439854 0.367893231366296 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) antigen KI-67 -- -- -- -- -- IPR000253 [Forkhead-associated (FHA) domain] ; IPR012568[K167R] ; IPR029334[Protein phosphatase 1 binding domain] -- -- Q8BYA0 Tubulin-specific chaperone D Tbcd 2414.8 2387.5 2383.5 2192 2194.8 2212.9 1.08880706698789 0.0000783708311672262 0.122748335910552 Nonsignificant None -- -- tubulin-specific chaperone D -- -- Beta-tubulin folding cofactor D O Posttranslational modification, protein turnover, chaperones ; IPR022577 [Tubulin-specific chaperone D, C-terminal] -- -- P62911 60S ribosomal protein L32 Rpl32 6901.4 7090.7 5993.5 5092.3 5142 5312.5 1.2855121311138 0.0127749624645228 0.362343224652423 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L32e -- ko03010 Ribosome 60S ribosomal protein L32 J Translation, ribosomal structure and biogenesis ; IPR001515 [Ribosomal protein L32e] -- -- Q9DAW9 Calponin-3 Cnn3 2461.4 2481.7 2211.5 2241.6 2240.4 2089 1.08881448790138 0.125210884498353 0.122758168762426 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Calponin Z Cytoskeleton ; IPR000557 [Calponin repeat] ; IPR001715[Calponin homology domain] -- -- Q3TMB8 Adenylosuccinate lyase Adsl 3250.5 2967.6 2600 2615.1 2580.8 2688 1.11849465366126 0.178263516561443 0.161558360415965 Nonsignificant None -- -- adenylosuccinate lyase 4.3.2.2 ko00230 Purine metabolism ko00250 Alanine, aspartate and glutamate metabolism ko01100 Metabolic pathways Adenylosuccinate lyase F Nucleotide transport and metabolism ; IPR019468 [Adenylosuccinate lyase C-terminal] ; IPR022761[Fumarate lyase, N-terminal] -- -- O08532 Voltage-dependent calcium channel subunit alpha-2/delta-1 Cacna2d1 2848.3 2906.6 3232.5 3482.2 3202.9 3663.4 0.868473691839397 0.0648552185954839 -0.203445947998557 Nonsignificant None -- -- voltage-dependent calcium channel alpha-2/delta-1 -- ko04010 MAPK signaling pathway ko04260 Cardiac muscle contraction ko04261 Adrenergic signaling in cardiomyocytes ko04921 Oxytocin signaling pathway ko05410 Hypertrophic cardiomyopathy (HCM) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05414 Dilated cardiomyopathy (DCM) L-type voltage-dependent Ca2+ channel, alpha2/delta subunit PT Inorganic ion transport and metabolism ; Signal transduction mechanisms ; IPR002035 [von Willebrand factor, type A] ; IPR013608[VWA N-terminal] ; IPR013680[Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region] -- -- Q923T9 Calcium/calmodulin-dependent protein kinase type II subunit gamma Camk2g 1036.6 1075.8 1138.9 1187.2 1117.1 1143.6 0.942979784796543 0.143932409504089 -0.0847012515441301 Nonsignificant None 5 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:calmodulin-dependent protein kinase activity (GO:0004683),Molecular Function:calmodulin binding (GO:0005516),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) calcium/calmodulin-dependent protein kinase (CaM kinase) II 2.7.11.17 ko04012 ErbB signaling pathway ko04020 Calcium signaling pathway ko04024 cAMP signaling pathway ko04066 HIF-1 signaling pathway ko04114 Oocyte meiosis ko04217 Necroptosis ko04261 Adrenergic signaling in cardiomyocytes ko04310 Wnt signaling pathway ko04360 Axon guidance ko04713 Circadian entrainment ko04720 Long-term potentiation ko04722 Neurotrophin signaling pathway ko04725 Cholinergic synapse ko04728 Dopaminergic synapse ko04740 Olfactory transduction ko04750 Inflammatory mediator regulation of TRP channels ko04911 Insulin secretion ko04912 GnRH signaling pathway ko04916 Melanogenesis ko04921 Oxytocin signaling pathway ko04922 Glucagon signaling pathway ko04925 Aldosterone synthesis and secretion ko04971 Gastric acid secretion ko05031 Amphetamine addiction ko05152 Tuberculosis ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05214 Glioma Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR013543[Calcium/calmodulin-dependent protein kinase II, association-domain] -- -- Q80TU6 MKIAA0670 protein (Fragment) Acin1 122.3 124.5 115.9 51.9 48 57.7 2.30139593908629 0.0000573009660000167 1.2025092105139 Significant up -- -- apoptotic chromatin condensation inducer in the nucleus -- ko03013 RNA transport ko03015 mRNA surveillance pathway ko03040 Spliceosome Acinus (induces apoptotic chromatin condensation) B Chromatin structure and dynamics ; IPR003034 [SAP domain] ; IPR032552[Acin1, RNSP1-SAP18 binding (RSB) motif] -- -- Q8BH97 Reticulocalbin-3 Rcn3 1985.1 2202 2349.7 2338.7 2454.8 2043.3 0.956119822139012 0.570247833593346 -0.0647366649937375 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) -- -- -- Reticulocalbin, calumenin, DNA supercoiling factor, and related Ca2+-binding proteins of the CREC family (EF-Hand protein superfamily) TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR002048 [EF-hand domain] -- -- Q9DCT2 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial Ndufs3 2863.6 2629 2141.2 2586.6 2453.3 2558.9 1.00460599041954 0.959628671078276 0.00662978287252544 Nonsignificant None 2 Molecular Function:NADH dehydrogenase (ubiquinone) activity (GO:0008137),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease NADH-ubiquinone oxidoreductase, NDUFS3/30 kDa subunit C Energy production and conversion ; IPR001268 [NADH:ubiquinone oxidoreductase, 30kDa subunit] -- -- Q9EQ20 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial Aldh6a1 2780 2773.9 3506.4 4193.9 3892.8 4429.7 0.723874276948643 0.016232561489449 -0.466188944226559 Nonsignificant None 3 Biological Process:metabolic process (GO:0008152),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00280 Valine, leucine and isoleucine degradation ko00410 beta-Alanine metabolism ko00562 Inositol phosphate metabolism ko00640 Propanoate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism Methylmalonate semialdehyde dehydrogenase EG Amino acid transport and metabolism ; Carbohydrate transport and metabolism ; IPR015590 [Aldehyde dehydrogenase domain] -- -- G3X8Z1 Calcium-activated chloride channel regulator 4A Clca4a 339.5 286.1 266.8 269.3 244.5 186.7 1.2739471805853 0.122380136562428 0.34930546292596 Nonsignificant None -- -- calcium-activated chloride channel regulator 3/4 -- ko04924 Renin secretion ko04972 Pancreatic secretion -- -- -- IPR002035 [von Willebrand factor, type A] ; IPR013642[Calcium-activated chloride channel protein] -- -- Q9Z277 Tyrosine-protein kinase BAZ1B Baz1b 2190.5 2241.1 2459.6 2423.8 2402.3 2300.8 0.966928117414303 0.4359940162278 -0.048519452863197 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) bromodomain adjacent to zinc finger domain protein 1B -- -- Chromatin remodeling complex WSTF-ISWI, large subunit (contains heterochromatin localization, PHD and BROMO domains) B Chromatin structure and dynamics ; IPR001487 [Bromodomain] ; IPR013136[WSTF/Acf1/Cbp146] ; IPR019787[Zinc finger, PHD-finger] ; IPR028941[WHIM2 domain] ; IPR028942[WHIM1 domain] -- -- P70441 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 Slc9a3r1 4738.7 4714.9 5437.7 5776.5 6150.7 5580.8 0.850542609092986 0.039675568201997 -0.233544583410975 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) Na(+)/H(+) exchange regulatory cofactor NHE-RF1 -- ko04530 Tight junction ko05165 Human papillomavirus infection FOG: PDZ domain S Function unknown ; IPR001478 [PDZ domain] ; IPR015098[EBP50, C-terminal] -- -- Q3TQR3 Eukaryotic translation initiation factor 5 Eif5 4383 4470.4 4638.9 4112.5 4108.4 4016 1.10259134257859 0.00679888864554627 0.140898178709299 Nonsignificant None 3 Molecular Function:translation initiation factor activity (GO:0003743),Molecular Function:protein binding (GO:0005515),Biological Process:translational initiation (GO:0006413) translation initiation factor 5 -- ko03013 RNA transport Translation initiation factor 5 (eIF-5) J Translation, ribosomal structure and biogenesis ; IPR002735 [Translation initiation factor IF2/IF5] ; IPR003307[W2 domain] -- -- Q3UC02 40S ribosomal protein S11 Rps11 12178.3 12257.6 9860.6 7928.6 8120.8 8176.1 1.41571897380859 0.0495306147034052 0.501534912786494 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S11e -- ko03010 Ribosome 40S ribosomal protein S11 J Translation, ribosomal structure and biogenesis ; IPR000266 [Ribosomal protein S17/S11] ; IPR032440[40S ribosomal protein S11, N-terminal] -- -- A2CF88 Arachidonate 15-lipoxygenase Alox15 2340.3 2798.5 2219.5 1439.8 1479.2 1407.9 1.70059395872334 0.0277525745756337 0.766038717918396 Significant up 3 Molecular Function:protein binding (GO:0005515),Molecular Function:metal ion binding (GO:0046872),Biological Process:oxidation-reduction process (GO:0055114) arachidonate 15-lipoxygenase 1.13.11.33 ko00590 Arachidonic acid metabolism ko00591 Linoleic acid metabolism ko01100 Metabolic pathways ko04216 Ferroptosis ko04217 Necroptosis ko04726 Serotonergic synapse -- -- -- IPR001024 [PLAT/LH2 domain] ; IPR013819[Lipoxygenase, C-terminal] -- -- Q9D1D4 Transmembrane emp24 domain-containing protein 10 Tmed10 5255.3 4891.1 4822.8 5028.5 5040.2 5248.7 0.977267682504864 0.487949430743354 -0.0331743112732464 Nonsignificant None 2 Biological Process:transport (GO:0006810),Cellular Component:integral component of membrane (GO:0016021) p24 family protein delta-1 -- -- emp24/gp25L/p24 family of membrane trafficking proteins U Intracellular trafficking, secretion, and vesicular transport ; IPR009038 [GOLD domain] -- -- O09106 Histone deacetylase 1 Hdac1 1302.4 1483 1683.7 1523.4 1622.9 1535.3 0.95460953520164 0.56966204951477 -0.0670173479384597 Nonsignificant None -- -- histone deacetylase 1/2 3.5.1.98 ko04110 Cell cycle ko04213 Longevity regulating pathway - multiple species ko04330 Notch signaling pathway ko04919 Thyroid hormone signaling pathway ko05016 Huntington's disease ko05034 Alcoholism ko05165 Human papillomavirus infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05202 Transcriptional misregulation in cancer ko05203 Viral carcinogenesis ko05220 Chronic myeloid leukemia Histone deacetylase complex, catalytic component RPD3 B Chromatin structure and dynamics ; IPR023801 [Histone deacetylase domain] -- -- Q922Q1 Mitochondrial amidoxime reducing component 2 Mtarc2 3483.5 3315.5 4037.2 4894 4606.9 4928.3 0.750991045934633 0.00761637492774705 -0.413132388296566 Nonsignificant None 3 Molecular Function:catalytic activity (GO:0003824),Molecular Function:molybdenum ion binding (GO:0030151),Molecular Function:pyridoxal phosphate binding (GO:0030170) -- -- -- Uncharacterized Fe-S protein R General function prediction only ; IPR005302 [Molybdenum cofactor sulfurase, C-terminal] ; IPR005303[MOSC, N-terminal beta barrel] -- -- A1L367 RAD21 homolog (S. pombe) Rad21 1560.5 1543.3 1428.7 1509 1452.9 1457.1 1.02568454401448 0.449011814977286 0.0365870888745148 Nonsignificant None 2 Cellular Component:nuclear chromosome (GO:0000228),Molecular Function:protein binding (GO:0005515) cohesin complex subunit SCC1 -- ko04110 Cell cycle Sister chromatid cohesion complex Cohesin, subunit RAD21/SCC1 D Cell cycle control, cell division, chromosome partitioning ; IPR006909 [Rad21/Rec8-like protein, C-terminal, eukaryotic] ; IPR006910[Rad21/Rec8-like protein, N-terminal] -- -- P70335 Rho-associated protein kinase 1 Rock1 2040.6 2108.3 2171.9 2098.2 2190.2 2096.5 0.989960688499429 0.684949846967427 -0.0145568582132773 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468),Molecular Function:Rho GTPase binding (GO:0017048) Rho-associated protein kinase 1 2.7.11.1 ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04062 Chemokine signaling pathway ko04071 Sphingolipid signaling pathway ko04270 Vascular smooth muscle contraction ko04350 TGF-beta signaling pathway ko04360 Axon guidance ko04510 Focal adhesion ko04530 Tight junction ko04611 Platelet activation ko04670 Leukocyte transendothelial migration ko04810 Regulation of actin cytoskeleton ko04921 Oxytocin signaling pathway ko05132 Salmonella infection ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05206 MicroRNAs in cancer Rho-associated, coiled-coil containing protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR015008[Rho binding domain] -- -- Q149F3 Eukaryotic peptide chain release factor GTP-binding subunit ERF3B Gspt2 349.9 299.8 315.4 323.4 333.2 311.5 0.996901146575767 0.953385574732385 -0.00447764183420353 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) peptide chain release factor subunit 3 -- ko03015 mRNA surveillance pathway Polypeptide release factor 3 J Translation, ribosomal structure and biogenesis ; IPR004160 [Translation elongation factor EFTu/EF1A, C-terminal] ; IPR004161[Translation elongation factor EFTu-like, domain 2] ; IPR009818[Ataxin-2, C-terminal] -- -- Q9D172 Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial Gatd3 2803.2 2660.1 3431.9 4087.8 3941.3 3956.7 0.742144871431194 0.0130036328651627 -0.430227257240157 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q80UM7 Mannosyl-oligosaccharide glucosidase Mogs 3555.4 3485.4 3705.9 3267.2 3371.7 3203.3 1.09190018491801 0.0208387220005443 0.126840979604342 Nonsignificant None -- -- mannosyl-oligosaccharide glucosidase 3.2.1.106 ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways ko04141 Protein processing in endoplasmic reticulum Glucosidase I G Carbohydrate transport and metabolism ; IPR031335 [Glycosyl hydrolase family 63, C-terminal] ; IPR031631[Glycosyl hydrolase family 63, N-terminal] -- -- Q99KF1 Transmembrane emp24 domain-containing protein 9 Tmed9 2808.2 3159.2 2471.7 2398.4 2478 2269.9 1.18090480388453 0.106446441987644 0.239892669646841 Nonsignificant None 2 Biological Process:transport (GO:0006810),Cellular Component:integral component of membrane (GO:0016021) p24 family protein alpha -- -- emp24/gp25L/p24 family of membrane trafficking proteins U Intracellular trafficking, secretion, and vesicular transport ; IPR009038 [GOLD domain] -- -- A0JLN1 Srp72 protein (Fragment) Srp72 2351.7 2372.5 2179.1 2125.8 2257.2 2103.3 1.06428934831876 0.148721045571086 0.0898904296309616 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) signal recognition particle subunit SRP72 -- ko03060 Protein export Signal recognition particle, subunit Srp72 U Intracellular trafficking, secretion, and vesicular transport ; IPR019734 [Tetratricopeptide repeat] ; IPR031545[Putative TPR-like repeat] -- -- Q8CCK0 Core histone macro-H2A.2 Macroh2a2 2283.7 2323.5 2532.1 2716.1 2594.8 2790.7 0.881220993384023 0.0286838947395726 -0.182424230023041 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) histone H2A -- ko04217 Necroptosis ko05034 Alcoholism ko05322 Systemic lupus erythematosus Histone 2A B Chromatin structure and dynamics ; IPR002589 [Macro domain] ; IPR007125[Histone H2A/H2B/H3] ; IPR032454[Histone H2A, C-terminal domain] -- -- Q9D0M3 Cytochrome c1, heme protein, mitochondrial Cyc1 4877.3 4985.9 3492.7 3568.9 3584.4 3604.7 1.24148540620933 0.213347099512455 0.312067302583484 Nonsignificant None 2 Molecular Function:electron carrier activity (GO:0009055),Molecular Function:heme binding (GO:0020037) ubiquinol-cytochrome c reductase cytochrome c1 subunit -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04260 Cardiac muscle contraction ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Cytochrome c1 C Energy production and conversion ; IPR002326 [Cytochrome c1] -- -- Q91V55 40S ribosomal protein S5 Rps5 4334.8 4685.7 4871.7 4759.7 4776.9 4502.6 0.989529317909852 0.7996610234113 -0.0151856426155255 Nonsignificant None -- -- small subunit ribosomal protein S5e -- ko03010 Ribosome Ribosomal protein S7 J Translation, ribosomal structure and biogenesis ; IPR023798 [Ribosomal protein S7 domain] -- -- Q99JR5 Tubulointerstitial nephritis antigen-like Tinagl1 1773.8 1905.3 1834.5 1957.5 1873.7 1856.9 0.969321917687804 0.301827261224937 -0.0449522218957381 Nonsignificant None 2 Biological Process:proteolysis (GO:0006508),Molecular Function:cysteine-type peptidase activity (GO:0008234) -- -- -- Predicted cysteine proteinase TIN-ag R General function prediction only ; IPR000668 [Peptidase C1A, papain C-terminal] -- -- Q3TYK4 Uncharacterized protein Prkar1a 5745.1 5433.7 5335.7 5797.5 6012.5 5949.8 0.929880967128008 0.0404426898750628 -0.104882044392506 Nonsignificant None -- -- cAMP-dependent protein kinase regulator -- ko04910 Insulin signaling pathway cAMP-dependent protein kinase types I and II, regulatory subunit T Signal transduction mechanisms ; IPR000595 [Cyclic nucleotide-binding domain] ; IPR003117[cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain] -- -- Q8R1Q8 Cytoplasmic dynein 1 light intermediate chain 1 Dync1li1 5085.4 5056.3 5213.2 4959.4 5031.4 4771 1.04017802706987 0.0964939438049592 0.0568304675880397 Nonsignificant None -- -- dynein light intermediate chain 1, cytosolic -- ko04145 Phagosome ko04962 Vasopressin-regulated water reabsorption ko05132 Salmonella infection Dynein light intermediate chain N Cell motility ; IPR022780 [Dynein family light intermediate chain] -- -- Q3TJ94 Prothrombin F2 2753.7 2679.3 2398.3 2288.3 2230.1 2015.3 1.19860109891792 0.0338188864712518 0.261351601733065 Nonsignificant None 5 Molecular Function:serine-type endopeptidase activity (GO:0004252),Molecular Function:calcium ion binding (GO:0005509),Cellular Component:extracellular region (GO:0005576),Biological Process:proteolysis (GO:0006508),Biological Process:blood coagulation (GO:0007596) coagulation factor II (thrombin) 3.4.21.5 ko04080 Neuroactive ligand-receptor interaction ko04610 Complement and coagulation cascades ko04810 Regulation of actin cytoskeleton -- -- -- IPR000001 [Kringle] ; IPR000294[Gamma-carboxyglutamic acid-rich (GLA) domain] ; IPR001254[Serine proteases, trypsin domain] ; IPR018992[Thrombin light chain] -- -- Q99JB2 Stomatin-like protein 2, mitochondrial Stoml2 2328.2 2222.9 2459.3 2008 2078.7 2090.6 1.13486474673401 0.0191015618764873 0.182520367257685 Nonsignificant None -- -- -- -- -- Prohibitins and stomatins of the PID superfamily C Energy production and conversion ; IPR001107 [Band 7 domain] ; IPR032435[Band 7, C-terminal extension] -- -- Q11136 Xaa-Pro dipeptidase Pepd 3524.5 3524.1 3922.1 3846.3 3828.9 4032.8 0.937025965152033 0.171655641042962 -0.0938390691191648 Nonsignificant None 2 Molecular Function:aminopeptidase activity (GO:0004177),Molecular Function:manganese ion binding (GO:0030145) Xaa-Pro dipeptidase 3.4.13.9 -- Putative metallopeptidase R General function prediction only ; IPR000994 [Peptidase M24] ; IPR007865[Aminopeptidase P, N-terminal] -- -- D3Z041 Long-chain-fatty-acid--CoA ligase Acsl1 2132.6 2219.8 2236.5 2336.7 2342.2 2479.8 0.920404542724238 0.0287677630313602 -0.119659990780426 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) long-chain acyl-CoA synthetase 6.2.1.3 ko00061 Fatty acid biosynthesis ko00071 Fatty acid degradation ko01100 Metabolic pathways ko01212 Fatty acid metabolism ko03320 PPAR signaling pathway ko04146 Peroxisome ko04216 Ferroptosis ko04920 Adipocytokine signaling pathway Long-chain acyl-CoA synthetases (AMP-forming) I Lipid transport and metabolism ; IPR000873 [AMP-dependent synthetase/ligase] -- -- Q91V64 Isochorismatase domain-containing protein 1 Isoc1 2823.6 2704.9 3255.8 3137 2830.9 3154.7 0.962916273869292 0.598848508764494 -0.054517734539136 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) -- -- -- Mitochondrial associated endoribonuclease MAR1 (isochorismatase superfamily) R General function prediction only ; IPR000868 [Isochorismatase-like] -- -- Q6P5D8 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 Smchd1 2959.5 2884.5 2620.3 2376.2 2491 2521.7 1.14554263828175 0.032878384480357 0.196031158243466 Nonsignificant None 4 Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Cellular Component:chromosome (GO:0005694),Biological Process:chromosome organization (GO:0051276) -- -- -- -- -- -- IPR010935 [SMCs flexible hinge] -- -- Q60865 Caprin-1 Caprin1 5666.6 5709.6 4653 3830.2 3855.2 3825.3 1.39254780334819 0.0486430380864713 0.477726853216748 Nonsignificant None -- -- caprin-1 -- -- -- -- -- IPR022070 [Cytoplasmic activation/proliferation-associated protein-1 C term] -- -- Q9DCC5 Cbx3 protein Cbx3 3351.1 3359.8 3560 3067.6 3126 3129.7 1.10163783209808 0.0113289328498927 0.13965001001315 Nonsignificant None 1 Cellular Component:nucleus (GO:0005634) chromobox protein 3 -- -- Heterochromatin-associated protein HP1 and related CHROMO domain proteins B Chromatin structure and dynamics ; IPR008251 [Chromo shadow domain] ; IPR023780[Chromo domain] -- -- Q61599 Rho GDP-dissociation inhibitor 2 Arhgdib 3667.6 5290.6 3560.8 1970.6 2213.2 2051.1 2.00789106481259 0.0623506753283721 1.0056810001065 Nonsignificant None 2 Molecular Function:Rho GDP-dissociation inhibitor activity (GO:0005094),Cellular Component:cytoplasm (GO:0005737) Rho GDP-dissociation inhibitor -- ko04722 Neurotrophin signaling pathway ko04962 Vasopressin-regulated water reabsorption Rho GDP-dissociation inhibitor T Signal transduction mechanisms ; IPR000406 [Rho protein GDP-dissociation inhibitor] -- -- B9EJ54 Nucleoporin 205 Nup205 2630.9 2547.9 2485.1 2284.6 2360.6 2363.3 1.09351501747878 0.0115527572214398 0.128973033365783 Nonsignificant None 1 Cellular Component:nuclear pore (GO:0005643) nuclear pore complex protein Nup205 -- ko03013 RNA transport Uncharacterized conserved protein S Function unknown ; IPR021827 [Nucleoporin Nup186/Nup192/Nup205] -- -- A0A0J9YUM4 C-terminal-binding protein 1 Ctbp1 2498.1 2148.1 2021.1 2083.3 2166.3 2149.2 1.04196099268613 0.570103913810098 0.0593012692559147 Nonsignificant None 3 Biological Process:metabolic process (GO:0008152),Molecular Function:NAD binding (GO:0051287),Biological Process:oxidation-reduction process (GO:0055114) C-terminal binding protein -- ko04310 Wnt signaling pathway ko04330 Notch signaling pathway ko05200 Pathways in cancer ko05220 Chronic myeloid leukemia Transcription factor CtBP K Transcription ; IPR006139 [D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain] ; IPR006140[D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain] -- -- Q3TJN6 Sorting nexin Snx5 4286.7 4165.8 4730.2 4610.3 4974.7 4733 0.9207081994692 0.134622818800884 -0.119184100223568 Nonsignificant None 1 Molecular Function:phosphatidylinositol binding (GO:0035091) sorting nexin-5/6/32 -- ko04144 Endocytosis Sorting nexin SNX6/TFAF2, contains PX domain V Defense mechanisms ; IPR001683 [Phox homologous domain] ; IPR015404[Sorting nexin Vps5-like, C-terminal] -- -- Q8C3C9 Aldehyde dehydrogenase Aldh3a2 3242.9 3193.3 3081.4 3172.4 3115.5 3337.4 0.988810738366596 0.683809459362517 -0.0162336840640535 Nonsignificant None 3 Biological Process:metabolic process (GO:0008152),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) aldehyde dehydrogenase (NAD+) 1.2.1.3 ko00010 Glycolysis / Gluconeogenesis ko00053 Ascorbate and aldarate metabolism ko00071 Fatty acid degradation ko00280 Valine, leucine and isoleucine degradation ko00310 Lysine degradation ko00330 Arginine and proline metabolism ko00340 Histidine metabolism ko00380 Tryptophan metabolism ko00410 beta-Alanine metabolism ko00561 Glycerolipid metabolism ko00620 Pyruvate metabolism ko01100 Metabolic pathways Aldehyde dehydrogenase C Energy production and conversion ; IPR015590 [Aldehyde dehydrogenase domain] -- -- Q9Z2H5 Band 4.1-like protein 1 Epb41l1 150.8 150.3 150.6 170.6 154.4 179.5 0.895341922695738 0.13881534004145 -0.159489355556203 Nonsignificant None 5 Molecular Function:actin binding (GO:0003779),Molecular Function:structural molecule activity (GO:0005198),Cellular Component:cytoskeleton (GO:0005856),Molecular Function:cytoskeletal protein binding (GO:0008092),Biological Process:cortical actin cytoskeleton organization (GO:0030866) erythrocyte membrane protein band 4.1 -- -- Erythrocyte membrane protein 4.1 and related proteins of the ERM family R General function prediction only ; IPR007477 [SAB domain] ; IPR008379[Band 4.1, C-terminal] ; IPR014847[FERM adjacent (FA)] ; IPR018979[FERM, N-terminal] ; IPR018980[FERM, C-terminal PH-like domain] ; IPR019748[FERM central domain] -- -- Q3UHW9 ADF-H domain-containing protein Cfl2 3283 3550.6 3656.7 3986.7 3900.9 3649.5 0.909266626795295 0.0810379865712228 -0.137224692929813 Nonsignificant None 2 Molecular Function:actin binding (GO:0003779),Cellular Component:intracellular (GO:0005622) cofilin -- ko04360 Axon guidance ko04666 Fc gamma R-mediated phagocytosis ko04810 Regulation of actin cytoskeleton ko05133 Pertussis Actin depolymerizing factor Z Cytoskeleton ; IPR002108 [Actin-depolymerising factor homology domain] -- -- Q921X9 Protein disulfide-isomerase A5 Pdia5 2752.7 2597.4 3009.7 3443.9 3412 3439 0.812033142624018 0.0322828430116104 -0.300389483580931 Nonsignificant None 1 Biological Process:cell redox homeostasis (GO:0045454) protein disulfide isomerase family A, member 5 5.3.4.1 -- Thioredoxin/protein disulfide isomerase O Posttranslational modification, protein turnover, chaperones ; IPR013766 [Thioredoxin domain] -- -- Q8CHG3 GRIP and coiled-coil domain-containing protein 2 Gcc2 2778.5 2856.5 2662.1 2847.8 2882.6 2830.9 0.969140200670459 0.206654176764402 -0.0452227066661699 Nonsignificant None 2 Biological Process:protein targeting to Golgi (GO:0000042),Molecular Function:protein binding (GO:0005515) GRIP and coiled-coil domain-containing protein 2 -- -- -- -- -- IPR000237 [GRIP domain] ; IPR032023[GCC2, Rab binding domain] -- -- Q8R5C5 Beta-centractin Actr1b 517.9 474.9 556.9 683 682.1 715.2 0.744940633562467 0.00246198604649456 -0.424802637202076 Nonsignificant None -- -- centractin -- -- Actin and related proteins Z Cytoskeleton ; IPR004000 [Actin family] -- -- Q9JJU8 SH3 domain-binding glutamic acid-rich-like protein Sh3bgrl 2772.2 2841 3169.3 3347 3451.7 3672.2 0.838753115778013 0.0223956374305332 -0.253681874278995 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR006993 [SH3-binding, glutamic acid-rich protein] -- -- Q9WUQ2 Prolactin regulatory element-binding protein Preb 2148.1 2179.6 2288.7 2271.4 2258.8 2204.1 0.982492612446728 0.453141449854016 -0.0254815353802807 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) prolactin regulatory element-binding protein -- ko04141 Protein processing in endoplasmic reticulum Prolactin regulatory element-binding protein/Protein transport protein SEC12p U Intracellular trafficking, secretion, and vesicular transport ; IPR001680 [WD40 repeat] -- -- A0A0G2JGS4 Calcium/calmodulin-dependent protein kinase Camk2d 99.7 87.9 83.5 123.9 104.5 108.9 0.803735546990809 0.0440910314932593 -0.315207205180415 Nonsignificant None 5 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:calmodulin-dependent protein kinase activity (GO:0004683),Molecular Function:calmodulin binding (GO:0005516),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) calcium/calmodulin-dependent protein kinase (CaM kinase) II 2.7.11.17 ko04012 ErbB signaling pathway ko04020 Calcium signaling pathway ko04024 cAMP signaling pathway ko04066 HIF-1 signaling pathway ko04114 Oocyte meiosis ko04217 Necroptosis ko04261 Adrenergic signaling in cardiomyocytes ko04310 Wnt signaling pathway ko04360 Axon guidance ko04713 Circadian entrainment ko04720 Long-term potentiation ko04722 Neurotrophin signaling pathway ko04725 Cholinergic synapse ko04728 Dopaminergic synapse ko04740 Olfactory transduction ko04750 Inflammatory mediator regulation of TRP channels ko04911 Insulin secretion ko04912 GnRH signaling pathway ko04916 Melanogenesis ko04921 Oxytocin signaling pathway ko04922 Glucagon signaling pathway ko04925 Aldosterone synthesis and secretion ko04971 Gastric acid secretion ko05031 Amphetamine addiction ko05152 Tuberculosis ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05214 Glioma Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR013543[Calcium/calmodulin-dependent protein kinase II, association-domain] -- -- Q9WVE8 Protein kinase C and casein kinase substrate in neurons protein 2 Pacsin2 4702.4 5021.9 5001.1 5413.6 5377.3 5393.1 0.909873949579832 0.0409817345013187 -0.136261401127738 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) protein kinase C and casein kinase substrate in neurons protein -- -- Adaptor protein PACSIN TUZ Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; Cytoskeleton ; IPR001060 [FCH domain] ; IPR001452[SH3 domain] -- -- E9Q1W0 Calcium/calmodulin-dependent protein kinase Camk2d 130.2 129 128.9 167.9 159.9 142.1 0.825920408597574 0.0696505023270297 -0.275925334615667 Nonsignificant None 5 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:calmodulin-dependent protein kinase activity (GO:0004683),Molecular Function:calmodulin binding (GO:0005516),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) calcium/calmodulin-dependent protein kinase (CaM kinase) II 2.7.11.17 ko04012 ErbB signaling pathway ko04020 Calcium signaling pathway ko04024 cAMP signaling pathway ko04066 HIF-1 signaling pathway ko04114 Oocyte meiosis ko04217 Necroptosis ko04261 Adrenergic signaling in cardiomyocytes ko04310 Wnt signaling pathway ko04360 Axon guidance ko04713 Circadian entrainment ko04720 Long-term potentiation ko04722 Neurotrophin signaling pathway ko04725 Cholinergic synapse ko04728 Dopaminergic synapse ko04740 Olfactory transduction ko04750 Inflammatory mediator regulation of TRP channels ko04911 Insulin secretion ko04912 GnRH signaling pathway ko04916 Melanogenesis ko04921 Oxytocin signaling pathway ko04922 Glucagon signaling pathway ko04925 Aldosterone synthesis and secretion ko04971 Gastric acid secretion ko05031 Amphetamine addiction ko05152 Tuberculosis ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05214 Glioma Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR013543[Calcium/calmodulin-dependent protein kinase II, association-domain] -- -- Q91WU5 Arsenite methyltransferase As3mt 2885.8 2896.1 3233.3 3982 3847.5 3715.2 0.780895129366722 0.00360408729439464 -0.356799280836768 Nonsignificant None -- -- arsenite methyltransferase 2.1.1.137 -- -- -- -- IPR025714 [Methyltransferase domain] -- -- Q9CZW5 Mitochondrial import receptor subunit TOM70 Tomm70 5377.5 5560 5710.2 5472.9 5451.6 5403.9 1.01955488596556 0.339970016032004 0.0279394424255507 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) mitochondrial import receptor subunit TOM70 -- -- Translocase of outer mitochondrial membrane complex, subunit TOM70/TOM72 U Intracellular trafficking, secretion, and vesicular transport ; IPR001440 [Tetratricopeptide repeat 1] ; IPR019734[Tetratricopeptide repeat] -- -- Q8CAS9 Protein mono-ADP-ribosyltransferase PARP9 Parp9 2552.6 2508.3 1950.8 1947.8 2264.7 2156.2 1.10096251982351 0.374849623945063 0.138765355927589 Nonsignificant None -- -- poly [ADP-ribose] polymerase 9 2.4.2.30 -- Hismacro and SEC14 domain-containing proteins BK Chromatin structure and dynamics ; Transcription ; IPR002589 [Macro domain] -- -- P99027 60S acidic ribosomal protein P2 Rplp2 5513.4 5691.6 5925.9 5199.9 5573.8 4959.4 1.08884453794866 0.0961023570583891 0.12279798496291 Nonsignificant None -- -- large subunit ribosomal protein LP2 -- ko03010 Ribosome 60S acidic ribosomal protein P2 J Translation, ribosomal structure and biogenesis ; -- -- -- E9Q912 Rap1 GTPase-GDP dissociation stimulator 1 Rap1gds1 2327.4 2401.6 2555.5 2523.5 2430.3 2416.1 0.988412325811748 0.724070388320631 -0.0168150932487842 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Rho/Rac GTPase guanine nucleotide exchange factor smgGDS/Vimar T Signal transduction mechanisms ; IPR000225 [Armadillo] -- -- Q78P93 Ceramidase Asah1 3223 3026.5 3344.9 3622.8 3508.9 3798.5 0.87778814660299 0.0237164408744374 -0.188055306294438 Nonsignificant None -- -- acid ceramidase 3.5.1.23 ko00600 Sphingolipid metabolism ko01100 Metabolic pathways ko04071 Sphingolipid signaling pathway ko04142 Lysosome -- -- -- IPR029130 [Acid ceramidase, N-terminal] ; IPR029132[Choloylglycine hydrolase/NAAA C-terminal] -- -- E9QN99 Protein ABHD14B Abhd14b 488.2 440.4 564.3 555.2 476.2 567 0.933996496496497 0.486991350416194 -0.0985109566190312 Nonsignificant None -- -- abhydrolase domain-containing protein 14 -- -- -- -- -- IPR000073 [Alpha/beta hydrolase fold-1] -- -- Q9D0M1 Phosphoribosyl pyrophosphate synthase-associated protein 1 Prpsap1 1260.1 1134.5 1189.4 1166.6 1208.7 1260.9 0.98564435399593 0.721296222308387 -0.0208609161169352 Nonsignificant None 3 Molecular Function:magnesium ion binding (GO:0000287),Molecular Function:ribose phosphate diphosphokinase activity (GO:0004749),Biological Process:nucleotide biosynthetic process (GO:0009165) -- -- -- Phosphoribosylpyrophosphate synthetase-associated protein EF Amino acid transport and metabolism ; Nucleotide transport and metabolism ; IPR005946 [Ribose-phosphate diphosphokinase] ; IPR029099[Ribose-phosphate pyrophosphokinase, N-terminal domain] -- -- Q9DD05 Delta-aminolevulinic acid dehydratase Alad 2248.7 2193.3 2194.5 2062.8 2013 2264.2 1.0467665615142 0.278751904015669 0.0659397439921239 Nonsignificant None 3 Molecular Function:porphobilinogen synthase activity (GO:0004655),Biological Process:tetrapyrrole biosynthetic process (GO:0033014),Molecular Function:metal ion binding (GO:0046872) porphobilinogen synthase 4.2.1.24 ko00860 Porphyrin and chlorophyll metabolism ko01100 Metabolic pathways Delta-aminolevulinic acid dehydratase H Coenzyme transport and metabolism ; IPR001731 [Delta-aminolevulinic acid dehydratase] -- -- Q80V08 60S ribosomal protein L17 (Fragment) Rpl17 9941.5 10117.7 10382.9 7919.5 7992 7433.5 1.3040094238595 0.000403785284710515 0.382954295724081 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L17e -- ko03010 Ribosome 60S ribosomal protein L22 J Translation, ribosomal structure and biogenesis ; IPR001063 [Ribosomal protein L22/L17] -- -- Q4KL76 10 kDa heat shock protein, mitochondrial Hspe1 8742.6 8923.3 8225.9 7171.3 7328.3 7000.6 1.2042585650366 0.00309391338357324 0.268145184827437 Nonsignificant None 2 Cellular Component:cytoplasm (GO:0005737),Biological Process:protein folding (GO:0006457) chaperonin GroES -- -- Mitochondrial chaperonin O Posttranslational modification, protein turnover, chaperones ; IPR020818 [GroES chaperonin family] -- -- A0A1W2P7A1 40S ribosomal protein S12 Rps12 5353.6 5291.2 4597.2 4584.9 4589.2 4765.6 1.09342381830312 0.156995875818849 0.12885270755111 Nonsignificant None -- -- small subunit ribosomal protein S12e -- ko03010 Ribosome 40S ribosomal protein S12 J Translation, ribosomal structure and biogenesis ; IPR004038 [Ribosomal protein L7Ae/L30e/S12e/Gadd45] -- -- E9PYH2 Cytosolic acyl coenzyme A thioester hydrolase Acot7 3779.5 3662.3 3157.7 3269.7 3459.8 3334.8 1.05317806504178 0.420126758072408 0.0747493792264005 Nonsignificant None -- -- acyl-coenzyme A thioesterase 7 3.1.2.2 ko00062 Fatty acid elongation ko01040 Biosynthesis of unsaturated fatty acids Acyl-CoA thioesterase I Lipid transport and metabolism ; IPR006683 [Thioesterase domain] -- -- A7YY79 RNA helicase (Fragment) Ddx58 2392 2184.8 2188.4 2196.9 2213.4 2338.1 1.00248947898761 0.94864469722077 0.0035870958402492 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Molecular Function:ATP binding (GO:0005524),Molecular Function:hydrolase activity (GO:0016787) ATP-dependent RNA helicase DDX58 3.6.3.14 ko04064 NF-kappa B signaling pathway ko04622 RIG-I-like receptor signaling pathway ko04623 Cytosolic DNA-sensing pathway ko05160 Hepatitis C ko05161 Hepatitis B ko05162 Measles ko05164 Influenza A ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection DEAD-box like helicase R General function prediction only ; IPR001650 [Helicase, C-terminal] ; IPR006935[Helicase/UvrB, N-terminal] ; IPR021673[C-terminal domain of RIG-I] ; IPR031964[Caspase recruitment domain] -- -- A2AUK7 Band 4.1-like protein 1 Epb41l1 301.5 257 292.3 487.2 448.6 446.3 0.615584979379206 0.000733222426400384 -0.699970065364695 Significant down 5 Molecular Function:actin binding (GO:0003779),Molecular Function:structural molecule activity (GO:0005198),Cellular Component:cytoskeleton (GO:0005856),Molecular Function:cytoskeletal protein binding (GO:0008092),Biological Process:cortical actin cytoskeleton organization (GO:0030866) erythrocyte membrane protein band 4.1 -- -- Erythrocyte membrane protein 4.1 and related proteins of the ERM family R General function prediction only ; IPR007477 [SAB domain] ; IPR008379[Band 4.1, C-terminal] ; IPR014847[FERM adjacent (FA)] ; IPR018979[FERM, N-terminal] ; IPR018980[FERM, C-terminal PH-like domain] ; IPR019748[FERM central domain] -- -- Q9CR16 Peptidyl-prolyl cis-trans isomerase D Ppid 3686.8 3877.1 3704.5 3314.4 3326.6 3366.7 1.12597300078939 0.00258192474533087 0.171172234083995 Nonsignificant None 4 Biological Process:protein peptidyl-prolyl isomerization (GO:0000413),Molecular Function:peptidyl-prolyl cis-trans isomerase activity (GO:0003755),Molecular Function:protein binding (GO:0005515),Biological Process:protein folding (GO:0006457) peptidyl-prolyl isomerase D 5.2.1.8 ko04217 Necroptosis ko04218 Cellular senescence HSP90 co-chaperone CPR7/Cyclophilin O Posttranslational modification, protein turnover, chaperones ; IPR002130 [Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain] ; IPR019734[Tetratricopeptide repeat] -- -- P63168 Dynein light chain 1, cytoplasmic Dynll1 1768.1 1763.7 1884 1899.1 1973.1 1807.5 0.953536278324559 0.229011632939944 -0.0686402664035708 Nonsignificant None 2 Biological Process:microtubule-based process (GO:0007017),Cellular Component:dynein complex (GO:0030286) dynein light chain LC8-type -- ko04962 Vasopressin-regulated water reabsorption Dynein light chain type 1 Z Cytoskeleton ; IPR001372 [Dynein light chain, type 1/2] -- -- Q9DBM2 Peroxisomal bifunctional enzyme Ehhadh 2680.8 2370.9 3173.1 2850.6 2925.8 3238.7 0.912335969650919 0.371647800355289 -0.132362897150755 Nonsignificant None 6 Molecular Function:catalytic activity (GO:0003824),Molecular Function:3-hydroxyacyl-CoA dehydrogenase activity (GO:0003857),Biological Process:fatty acid metabolic process (GO:0006631),Biological Process:metabolic process (GO:0008152),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00071 Fatty acid degradation ko00280 Valine, leucine and isoleucine degradation ko00310 Lysine degradation ko00380 Tryptophan metabolism ko00410 beta-Alanine metabolism ko00640 Propanoate metabolism ko00650 Butanoate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01212 Fatty acid metabolism ko03320 PPAR signaling pathway ko04146 Peroxisome Hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase I Lipid transport and metabolism ; IPR001753 [Crotonase superfamily] ; IPR006108[3-hydroxyacyl-CoA dehydrogenase, C-terminal] ; IPR006176[3-hydroxyacyl-CoA dehydrogenase, NAD binding] -- -- Q8C141 Propionate--CoA ligase Acss2 2914 2842.6 3055.8 4829.7 4489.3 4872.5 0.620963252651235 0.000193770691624757 -0.687420199688731 Significant down 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) acetyl-CoA synthetase 6.2.1.1 ko00010 Glycolysis / Gluconeogenesis ko00620 Pyruvate metabolism ko00640 Propanoate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism Acyl-CoA synthetase I Lipid transport and metabolism ; IPR000873 [AMP-dependent synthetase/ligase] ; IPR025110[AMP-binding enzyme C-terminal domain] ; IPR032387[Acetyl-coenzyme A synthetase, N-terminal domain] -- -- P16332 Methylmalonyl-CoA mutase, mitochondrial Mmut 3212.1 3015.6 3274.5 3815.7 3660.7 3803.1 0.842430958819097 0.003052088545602 -0.247369639394954 Nonsignificant None 4 Biological Process:metabolic process (GO:0008152),Molecular Function:intramolecular transferase activity (GO:0016866),Molecular Function:cobalamin binding (GO:0031419),Molecular Function:metal ion binding (GO:0046872) methylmalonyl-CoA mutase 5.4.99.2 ko00280 Valine, leucine and isoleucine degradation ko00630 Glyoxylate and dicarboxylate metabolism ko00640 Propanoate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism -- -- -- IPR006099 [Methylmalonyl-CoA mutase, alpha/beta chain, catalytic] ; IPR006158[Cobalamin (vitamin B12)-binding domain] -- -- Q3TG58 Eukaryotic translation initiation factor 4H Eif4h 247.7 218.2 186.3 218.4 218.4 196.6 1.02968108620145 0.760021909660143 0.0421975737202754 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- FOG: RRM domain R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- Q8BFU2 Histone H2A type 3 H2aw 2510.2 2428.5 2742 2236 2256.4 2841.5 1.04728725507574 0.626448660862851 0.0666572060063278 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) histone H2A -- ko04217 Necroptosis ko05034 Alcoholism ko05322 Systemic lupus erythematosus Histone 2A B Chromatin structure and dynamics ; IPR007125 [Histone H2A/H2B/H3] ; IPR032454[Histone H2A, C-terminal domain] -- -- B7ZP20 Ankyrin repeat and FYVE domain containing 1 Ankfy1 2191.5 2216.6 2310.7 2343.6 2388.7 2431.4 0.937895221742954 0.0285496249048889 -0.0925013358089858 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:metal ion binding (GO:0046872) rabankyrin-5 -- -- FOG: Ankyrin repeat R General function prediction only ; IPR000210 [BTB/POZ domain] ; IPR000306[FYVE zinc finger] ; IPR002110[Ankyrin repeat] ; IPR020683[Ankyrin repeat-containing domain] -- ZBTB Q9CQW2 ADP-ribosylation factor-like protein 8B Arl8b 364.4 398.9 458.6 427.8 428.4 413.8 0.962125984251969 0.596617446667318 -0.0557022768223194 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) ADP-ribosylation factor-like protein 8 -- -- GTP-binding ADP-ribosylation factor-like protein R General function prediction only ; IPR006689 [Small GTPase superfamily, ARF/SAR type] -- -- Q3ULS2 Structural maintenance of chromosomes protein Smc2 2062.7 2029.5 2011.5 1675 1693.6 1667.2 1.21206163866714 0.0000301519259558285 0.277463068066839 Nonsignificant None 4 Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Cellular Component:chromosome (GO:0005694),Biological Process:chromosome organization (GO:0051276) structural maintenance of chromosome 2 -- Structural maintenance of chromosome protein 2 (chromosome condensation complex Condensin, subunit E) BD Chromatin structure and dynamics ; Cell cycle control, cell division, chromosome partitioning ; IPR003395 [RecF/RecN/SMC, N-terminal] ; IPR010935[SMCs flexible hinge] -- -- A0A0R4J0W6 Leucine-rich repeat-containing protein 40 Lrrc40 2183.1 2054 2218.1 2088.6 2088.1 2043.7 1.03774676869655 0.207257659246477 0.0534544397297881 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Leucine-rich repeat protein S Function unknown ; IPR001611 [Leucine-rich repeat] ; IPR025875[Leucine rich repeat 4] -- -- Q3V244 Eukaryotic translation initiation factor 4H Eif4h 299.2 306.3 290.1 297.4 295.1 294.2 1.01003721664599 0.568776914216342 0.0144084526616274 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- FOG: RRM domain R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- Q5JCS9 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3 B3gnt3 3767.2 3559.5 3474 3993.8 4122.4 3883.3 0.900095837326555 0.0228494160753969 -0.151849474917617 Nonsignificant None 3 Biological Process:protein glycosylation (GO:0006486),Molecular Function:galactosyltransferase activity (GO:0008378),Cellular Component:membrane (GO:0016020) -- -- ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series ko01100 Metabolic pathways Galactosyltransferases G Carbohydrate transport and metabolism ; IPR002659 [Glycosyl transferase, family 31] -- -- Q3U6W4 Heme oxygenase Hmox2 1793.5 1680.2 1806.8 1744.6 1710.7 1682.9 1.02769452337394 0.341215937804923 0.0394114949731325 Nonsignificant None 3 Molecular Function:heme oxygenase (decyclizing) activity (GO:0004392),Biological Process:heme oxidation (GO:0006788),Biological Process:oxidation-reduction process (GO:0055114) heme oxygenase 2 1.14.14.18 ko00860 Porphyrin and chlorophyll metabolism ko01100 Metabolic pathways ko04978 Mineral absorption Heme oxygenase P Inorganic ion transport and metabolism ; IPR016053 [Haem oxygenase-like] -- -- O54734 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit Ddost 5126.4 5328.1 5980 5510.1 5285.1 5019.5 1.0391913852302 0.521010779195545 0.055461376182123 Nonsignificant None 2 Cellular Component:endoplasmic reticulum membrane (GO:0005789),Biological Process:protein N-linked glycosylation via asparagine (GO:0018279) oligosaccharyltransferase complex subunit beta -- ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways ko04141 Protein processing in endoplasmic reticulum Oligosaccharyltransferase, beta subunit O Posttranslational modification, protein turnover, chaperones ; IPR005013 [Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit] -- -- Q64516 Glycerol kinase Gk 2604.7 2550.8 2351.6 3109.5 3382.7 3394.6 0.75930533640814 0.00278359398957801 -0.397247947401784 Nonsignificant None 1 Biological Process:carbohydrate metabolic process (GO:0005975) glycerol kinase 2.7.1.30 ko00561 Glycerolipid metabolism ko01100 Metabolic pathways ko03320 PPAR signaling pathway Ribulose kinase and related carbohydrate kinases G Carbohydrate transport and metabolism ; IPR018484 [Carbohydrate kinase, FGGY, N-terminal] ; IPR018485[Carbohydrate kinase, FGGY, C-terminal] -- -- I6L978 Igk protein Igk 373.6 387.1 400.9 303.9 285 320.9 1.27676412398329 0.0029829238238564 0.352492018704096 Nonsignificant None -- -- immunoglobulin lambda-like polypeptide 1 -- -- -- -- -- IPR003597 [Immunoglobulin C1-set] ; IPR013106[Immunoglobulin V-set domain] -- -- E9QQ10 A-kinase anchor protein 9 Akap9 2577.8 2441.1 2891.2 2996.9 2997.8 3053.4 0.874227738420221 0.101642436924055 -0.193918940686888 Nonsignificant None -- -- A-kinase anchor protein 9 -- -- -- -- -- IPR019528 [Pericentrin/AKAP-450 centrosomal targeting domain] -- -- Q6AXB7 Synaptic functional regulator FMR1 Fmr1 339.1 313.9 305 263.2 281 282 1.15952553861051 0.0209756603747983 0.213534595767422 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) fragile X mental retardation protein -- ko03013 RNA transport -- -- -- IPR004088 [K Homology domain, type 1] ; IPR008395[Agenet-like domain] ; IPR022034[Fragile X-related 1 protein, C-terminal core] ; IPR032196[Fragile X-related mental retardation protein, C-terminal region 2] -- -- Q9Z0E6 Guanylate-binding protein 2 Gbp2 2411.9 3194 2204.6 1985.2 1810.4 1429.8 1.49471810770467 0.0658895303793978 0.579873428929794 Nonsignificant None 2 Molecular Function:GTPase activity (GO:0003924),Molecular Function:GTP binding (GO:0005525) guanylate-binding protein 2 -- ko04621 NOD-like receptor signaling pathway Guanylate-binding protein R General function prediction only ; IPR003191 [Guanylate-binding protein, C-terminal] ; IPR015894[Guanylate-binding protein, N-terminal] -- -- O35344 Importin subunit alpha-4 Kpna3 1143.3 1114.9 1300.7 1243.6 1340.5 1178.3 0.945912183712524 0.414400035756998 -0.080221841558601 Nonsignificant None 5 Molecular Function:protein binding (GO:0005515),Cellular Component:nucleus (GO:0005634),Cellular Component:cytoplasm (GO:0005737),Biological Process:protein import into nucleus (GO:0006606),Molecular Function:protein transporter activity (GO:0008565) -- -- -- Karyopherin (importin) alpha U Intracellular trafficking, secretion, and vesicular transport ; IPR000225 [Armadillo] ; IPR002652[Importin-alpha, importin-beta-binding domain] ; IPR032413[Atypical Arm repeat] -- -- P32020 Sterol carrier protein 2 Scp2 3757.4 3702.3 4448.3 3901.8 3973.2 4039.9 0.999420893167379 0.992910137166723 -0.000835716563516286 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) sterol carrier protein 2 2.3.1.176 ko00120 Primary bile acid biosynthesis ko01100 Metabolic pathways ko03320 PPAR signaling pathway ko04146 Peroxisome Peroxisomal 3-ketoacyl-CoA-thiolase P-44/SCP2 I Lipid transport and metabolism ; IPR003033 [SCP2 sterol-binding domain] ; IPR020616[Thiolase, N-terminal] ; IPR020617[Thiolase, C-terminal] -- -- Q3UJ44 Macrophage-capping protein Capg 5696.3 5998 4515 3928.1 4084.3 3766.6 1.37611851600306 0.0329490972647149 0.460604725190352 Nonsignificant None -- -- capping protein (actin filament), gelsolin-like -- -- Actin regulatory proteins (gelsolin/villin family) Z Cytoskeleton ; IPR007123 [Gelsolin-like domain] -- -- Q9DC51 Guanine nucleotide-binding protein G(i) subunit alpha-3 Gnai3 1998.5 2012.1 1951.3 1859 1848.5 2006.2 1.04343945254389 0.201187994322471 0.0613468879448106 Nonsignificant None 5 Molecular Function:GTPase activity (GO:0003924),Molecular Function:signal transducer activity (GO:0004871),Biological Process:G-protein coupled receptor signaling pathway (GO:0007186),Molecular Function:guanyl nucleotide binding (GO:0019001),Molecular Function:G-protein beta/gamma-subunit complex binding (GO:0031683) guanine nucleotide-binding protein G(i) subunit alpha -- ko04015 Rap1 signaling pathway ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04062 Chemokine signaling pathway ko04071 Sphingolipid signaling pathway ko04261 Adrenergic signaling in cardiomyocytes ko04360 Axon guidance ko04371 Apelin signaling pathway ko04540 Gap junction ko04611 Platelet activation ko04670 Leukocyte transendothelial migration ko04713 Circadian entrainment ko04723 Retrograde endocannabinoid signaling ko04724 Glutamatergic synapse ko04725 Cholinergic synapse ko04726 Serotonergic synapse ko04727 GABAergic synapse ko04728 Dopaminergic synapse ko04730 Long-term depression ko04914 Progesterone-mediated oocyte maturation ko04915 Estrogen signaling pathway ko04916 Melanogenesis ko04921 Oxytocin signaling pathway ko04923 Regulation of lipolysis in adipocytes ko04924 Renin secretion ko04926 Relaxin signaling pathway ko04971 Gastric acid secretion ko05012 Parkinson's disease ko05030 Cocaine addiction ko05032 Morphine addiction ko05034 Alcoholism ko05133 Pertussis ko05142 Chagas disease (American trypanosomiasis) ko05145 Toxoplasmosis ko05200 Pathways in cancer G-protein alpha subunit (small G protein superfamily) DT Cell cycle control, cell division, chromosome partitioning ; Signal transduction mechanisms ; IPR001019 [Guanine nucleotide binding protein (G-protein), alpha subunit] -- -- P26516 26S proteasome non-ATPase regulatory subunit 7 Psmd7 2687.6 2732.7 2362.9 2249 2292.3 2278.7 1.14123167155425 0.108560432753227 0.190591690378065 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) 26S proteasome regulatory subunit N8 -- ko03050 Proteasome ko05169 Epstein-Barr virus infection 26S proteasome regulatory complex, subunit RPN8/PSMD7 O Posttranslational modification, protein turnover, chaperones ; IPR000555 [JAB1/MPN/MOV34 metalloenzyme domain] ; IPR024969[Rpn11/EIF3F, C-terminal] -- -- Q9WTX6 Cullin-1 Cul1 2259.7 2349.7 2604.4 2511.7 2519.7 2517.7 0.95558410936403 0.392085206855623 -0.0655452318134233 Nonsignificant None 2 Biological Process:ubiquitin-dependent protein catabolic process (GO:0006511),Molecular Function:ubiquitin protein ligase binding (GO:0031625) cullin 1 -- ko04110 Cell cycle ko04114 Oocyte meiosis ko04120 Ubiquitin mediated proteolysis ko04141 Protein processing in endoplasmic reticulum ko04310 Wnt signaling pathway ko04340 Hedgehog signaling pathway ko04350 TGF-beta signaling pathway ko04710 Circadian rhythm ko05168 Herpes simplex infection ko05200 Pathways in cancer Cullins D Cell cycle control, cell division, chromosome partitioning ; IPR001373 [Cullin, N-terminal] ; IPR019559[Cullin protein, neddylation domain] -- -- Q91XV3 Brain acid soluble protein 1 Basp1 1461.3 1483.6 1757.3 1286.3 1366.8 1343.8 1.17646175786234 0.0747011411292534 0.234454424991408 Nonsignificant None -- -- brain acid soluble protein 1 -- -- -- -- -- IPR008408 [Brain acid soluble protein 1] -- -- O35744 Chitinase-like protein 3 Chil3 3880.4 6839.8 4407.9 1890 2046.1 1841.1 2.61858685868587 0.0752263470419228 1.38878845986347 Nonsignificant None 1 Biological Process:carbohydrate metabolic process (GO:0005975) chitinase 3-like 3/4 -- -- Chitinase G Carbohydrate transport and metabolism ; IPR001223 [Glycoside hydrolase family 18, catalytic domain] -- -- Q3UEG8 Complement factor B Cfb 2311.4 2420.5 2430.2 1476 1649.2 1577.2 1.52307332425995 0.000201679889235166 0.606985398161261 Significant up 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) component factor B 3.4.21.47 ko04610 Complement and coagulation cascades ko05150 Staphylococcus aureus infection Trypsin E Amino acid transport and metabolism ; IPR000436 [Sushi/SCR/CCP domain] ; IPR001254[Serine proteases, trypsin domain] ; IPR002035[von Willebrand factor, type A] -- -- Q9CR57 60S ribosomal protein L14 Rpl14 5338.7 5177.8 4919.5 4278.4 4157.7 4183.3 1.22319603150704 0.00181200133160767 0.290655631191347 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L14e -- ko03010 Ribosome 60S ribosomal protein L14 J Translation, ribosomal structure and biogenesis ; IPR002784 [Ribosomal protein L14e domain] -- -- I6L958 Igk protein Igk 48 47.4 36.5 58 42.5 49.5 0.879333333333333 0.359579406643561 -0.185517936131698 Nonsignificant None -- -- immunoglobulin lambda-like polypeptide 1 -- -- -- -- -- IPR003597 [Immunoglobulin C1-set] ; IPR013106[Immunoglobulin V-set domain] -- -- Q9DCM2 Glutathione S-transferase kappa 1 Gstk1 3630.3 3498.2 4048.8 4024.1 3588.4 4040.7 0.959161432052998 0.515106458378174 -0.0601544458355402 Nonsignificant None 1 Molecular Function:protein disulfide oxidoreductase activity (GO:0015035) glutathione S-transferase kappa 1 2.5.1.18 ko00480 Glutathione metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko04146 Peroxisome ko05204 Chemical carcinogenesis -- -- -- IPR001853 [DSBA-like thioredoxin domain] -- -- O08692 Neutrophilic granule protein Ngp 5043.1 9926.2 4922.5 2280.5 2240.2 2054.3 3.02536882129278 0.114377281517198 1.5971110313839 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q9D0F3 Protein ERGIC-53 Lman1 4414.9 4329 4788.7 4341.6 4167.1 4102.1 1.07309607637898 0.124045997332029 0.101779249170249 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) lectin, mannose-binding 1 -- ko04141 Protein processing in endoplasmic reticulum Mannose lectin ERGIC-53, involved in glycoprotein traffic U Intracellular trafficking, secretion, and vesicular transport ; IPR005052 [Legume-like lectin] -- -- P27046 Alpha-mannosidase 2 Man2a1 2853.5 2869 2770.3 2861.4 2998.9 2893.5 0.970184377070529 0.167148115139906 -0.0436691469608414 Nonsignificant None 5 Molecular Function:alpha-mannosidase activity (GO:0004559),Biological Process:carbohydrate metabolic process (GO:0005975),Biological Process:mannose metabolic process (GO:0006013),Molecular Function:zinc ion binding (GO:0008270),Molecular Function:mannosidase activity (GO:0015923) alpha-mannosidase II 3.2.1.114 ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways Glycosyl hydrolase, family 38 - alpha-mannosidase G Carbohydrate transport and metabolism ; IPR000602 [Glycoside hydrolase family 38, N-terminal domain] ; IPR011682[Glycosyl hydrolase family 38, C-terminal] ; IPR015341[Glycoside hydrolase family 38, central domain] -- -- Q8BWM0 Prostaglandin E synthase 2 Ptges2 906.3 797.9 816 862.3 866.8 917.6 0.952204632183474 0.328538805696221 -0.0706564477071725 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) microsomal prostaglandin-E synthase 2 5.3.99.3 ko00590 Arachidonic acid metabolism ko01100 Metabolic pathways Glutathione S-transferase-related protein R General function prediction only ; IPR004045 [Glutathione S-transferase, N-terminal] -- -- Q3TW82 Beta-glucuronidase Gusb 3511.3 3618.5 4232 3431.1 3498.8 3459.3 1.09361644784969 0.285127364546811 0.129106846166283 Nonsignificant None 1 Biological Process:carbohydrate metabolic process (GO:0005975) beta-glucuronidase 3.2.1.31 ko00040 Pentose and glucuronate interconversions ko00531 Glycosaminoglycan degradation ko00860 Porphyrin and chlorophyll metabolism ko00983 Drug metabolism - other enzymes ko01100 Metabolic pathways ko04142 Lysosome Beta-Glucuronidase GUSB (glycosylhydrolase superfamily 2) G Carbohydrate transport and metabolism ; IPR006102 [Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich] ; IPR006103[Glycoside hydrolase family 2, catalytic domain] ; IPR006104[Glycosyl hydrolases family 2, sugar binding domain] -- -- Q62219 Transforming growth factor beta-1-induced transcript 1 protein Tgfb1i1 2946.4 3075.4 2814 2926.7 2781 2858.5 1.0314725315776 0.357046412595253 0.0447054023349752 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) -- -- -- Adaptor protein Enigma and related PDZ-LIM proteins TZ Signal transduction mechanisms ; Cytoskeleton ; IPR001781 [Zinc finger, LIM-type] -- -- Q5M8Q0 Ribosomal protein L15 Rpl15 7150.4 7196.7 5578.3 4789.4 4779.3 5097.9 1.35855617525534 0.0318660749042937 0.442074221126123 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L15e -- ko03010 Ribosome 60s ribosomal protein L15 J Translation, ribosomal structure and biogenesis ; IPR000439 [Ribosomal protein L15e] -- -- A0A1Y7VN19 Dehydrogenase/reductase SDR family member 7 (Fragment) Dhrs7 1850.1 1817.5 2003.5 2069.9 2025.7 2148.1 0.908291557890353 0.0476475597493406 -0.13877262379716 Nonsignificant None -- -- dehydrogenase/reductase SDR family member 7 1.1.-.- -- Predicted dehydrogenase Q Secondary metabolites biosynthesis, transport and catabolism ; IPR002347 [Short-chain dehydrogenase/reductase SDR] -- -- P11531 Dystrophin Dmd 2945.2 2876.8 2987.4 3211.7 3126 3304.4 0.913639144999533 0.01027552075259 -0.130303630387504 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:zinc ion binding (GO:0008270) dystrophin -- ko05410 Hypertrophic cardiomyopathy (HCM) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05414 Dilated cardiomyopathy (DCM) ko05416 Viral myocarditis Dystrophin-like protein NTZ Cell motility ; Signal transduction mechanisms ; Cytoskeleton ; IPR000433 [Zinc finger, ZZ-type] ; IPR001202[WW domain] ; IPR001715[Calponin homology domain] ; IPR002017[Spectrin repeat] ; IPR015153[EF-hand domain, type 1] ; IPR015154[EF-hand domain, type 2] -- -- Q8CJG0 Protein argonaute-2 Ago2 3245.9 3221.4 3259.4 3258.1 3232.6 3343.7 0.98904864557065 0.367788813156694 -0.0158866143502783 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:protein binding (GO:0005515) eukaryotic translation initiation factor 2C -- -- Translation initiation factor 2C (eIF-2C) and related proteins J Translation, ribosomal structure and biogenesis ; IPR003100 [PAZ domain] ; IPR003165[Piwi domain] ; IPR014811[Argonaute, linker 1 domain] ; IPR032472[Argonaute linker 2 domain] ; IPR032473[Protein argonaute, Mid domain] ; IPR032474[Protein argonaute, N-terminal] -- -- D3YXK2 Scaffold attachment factor B1 Safb 3486.2 3585.9 4058.4 3426.4 3447.5 3326.6 1.09117200137248 0.160805127511235 0.125878531513487 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- Hsp27-ERE-TATA-binding protein/Scaffold attachment factor (SAF-B) K Transcription ; IPR000504 [RNA recognition motif domain] ; IPR003034[SAP domain] -- -- Q8BK64 Activator of 90 kDa heat shock protein ATPase homolog 1 Ahsa1 4452.4 4253 4484.3 4072.6 4215.5 3965.2 1.07642022965242 0.0381379918127734 0.106241409566422 Nonsignificant None 3 Molecular Function:ATPase activator activity (GO:0001671),Biological Process:response to stress (GO:0006950),Molecular Function:chaperone binding (GO:0051087) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR013538 [Activator of Hsp90 ATPase homologue 1-like] ; IPR015310[Activator of Hsp90 ATPase, N-terminal] -- -- B9EKB8 Insulin-like growth factor 2 receptor Igf2r 4118.8 3930.5 4351.3 3927.1 3960.3 3980.1 1.04492100273857 0.280791454772123 0.0633938769805202 Nonsignificant None 4 Molecular Function:transporter activity (GO:0005215),Cellular Component:cytoplasm (GO:0005737),Biological Process:transport (GO:0006810),Cellular Component:integral component of membrane (GO:0016021) insulin-like growth factor 2 receptor -- ko04142 Lysosome ko04144 Endocytosis Cation-independent mannose-6-phosphate receptor CI-MPR TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR000479 [Cation-independent mannose-6-phosphate receptor] ; IPR000562[Fibronectin, type II, collagen-binding] -- -- Q9D2V7 Coronin-7 Coro7 2746 2901.6 2837.4 2528.6 2629 2652.7 1.08638592627684 0.0189452218012532 0.119536695241927 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) coronin-7 -- -- Tumor-specific antigen (contains WD repeats) Z Cytoskeleton ; IPR001680 [WD40 repeat] ; IPR015048[Domain of unknown function DUF1899] -- -- P10833 Ras-related protein R-Ras Rras 2807.6 3048.3 3007.7 3507.4 3414.7 3327.2 0.864800522962544 0.00704136050501663 -0.209560699387371 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein R-Ras -- ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04024 cAMP signaling pathway ko04072 Phospholipase D signaling pathway ko04137 Mitophagy - animal ko04140 Autophagy - animal ko04218 Cellular senescence ko04360 Axon guidance ko04371 Apelin signaling pathway ko04810 Regulation of actin cytoskeleton ko05166 HTLV-I infection ko05205 Proteoglycans in cancer Ras-related GTPase R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- Q9D2D1 Carboxypeptidase Ctsa 1725 1623.8 1763.6 1986.8 1936.8 2220.2 0.832123441518279 0.0237413426783245 -0.265130533760992 Nonsignificant None 2 Molecular Function:serine-type carboxypeptidase activity (GO:0004185),Biological Process:proteolysis (GO:0006508) cathepsin A (carboxypeptidase C) 3.4.16.5 ko04142 Lysosome ko04614 Renin-angiotensin system Serine carboxypeptidases (lysosomal cathepsin A) OE Posttranslational modification, protein turnover, chaperones ; Amino acid transport and metabolism ; IPR001563 [Peptidase S10, serine carboxypeptidase] -- -- B1AX98 Leucine rich repeat containing 47 Lrrc47 2564.2 2816.2 2168.6 2111.2 2238.6 2063.1 1.17715853981818 0.12495008330622 0.23530863575992 Nonsignificant None 3 Molecular Function:RNA binding (GO:0003723),Molecular Function:phenylalanine-tRNA ligase activity (GO:0004826),Molecular Function:protein binding (GO:0005515) -- -- -- Phenylalanyl-tRNA synthetase beta subunit J Translation, ribosomal structure and biogenesis ; IPR001611 [Leucine-rich repeat] ; IPR005146[B3/B4 tRNA-binding domain] ; IPR025875[Leucine rich repeat 4] -- -- A0A5K1VVS7 Protein unc-45 homolog A Unc45a 1995.4 2030.6 1943.6 2087.8 2097.6 2161.8 0.940509200907487 0.0214122890631902 -0.0884860373285009 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) protein unc-45 -- -- Myosin assembly protein/sexual cycle protein and related proteins ODR Posttranslational modification, protein turnover, chaperones ; Cell cycle control, cell division, chromosome partitioning ; General function prediction only ; IPR019734 [Tetratricopeptide repeat] ; IPR024660[UNC-45/Cro1/She4, central domain] -- -- J3QP56 Palmitoyl-protein hydrolase Lypla1 3073.3 2983.8 3310.8 3252.6 3274.5 3328.5 0.950515442996875 0.17982493330778 -0.0732180283985748 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) lysophospholipase I 3.1.1.5 ko00564 Glycerophospholipid metabolism ko05231 Choline metabolism in cancer Lysophospholipase I Lipid transport and metabolism ; IPR003140 [Phospholipase/carboxylesterase/thioesterase] -- -- Q9QZD8 Mitochondrial dicarboxylate carrier Slc25a10 1914.5 1862.7 2242.3 2173.5 1996.4 2106.1 0.959130019120459 0.54538290002069 -0.060201695466946 Nonsignificant None -- -- solute carrier family 25 (mitochondrial dicarboxylate transporter), member 10 -- ko04964 Proximal tubule bicarbonate reclamation Mitochondrial oxoglutarate/malate carrier proteins C Energy production and conversion ; IPR018108 [Mitochondrial substrate/solute carrier] -- -- A0A1D5RM85 60S ribosomal protein L18a (Fragment) Rpl18a 5490.6 5261.5 4413.4 3899 3918.7 4028.8 1.28016713797324 0.075494764111441 0.356332180056217 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L18Ae -- ko03010 Ribosome 60S ribosomal protein L18A J Translation, ribosomal structure and biogenesis ; IPR023573 [Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A] -- -- P70697 Uroporphyrinogen decarboxylase Urod 2536.7 2562.1 2558.8 2511.5 2599.4 2641.4 0.987784270474569 0.464671773137941 -0.0177320995350623 Nonsignificant None 2 Molecular Function:uroporphyrinogen decarboxylase activity (GO:0004853),Biological Process:porphyrin-containing compound biosynthetic process (GO:0006779) uroporphyrinogen decarboxylase 4.1.1.37 ko00860 Porphyrin and chlorophyll metabolism ko01100 Metabolic pathways Uroporphyrinogen decarboxylase H Coenzyme transport and metabolism ; IPR000257 [Uroporphyrinogen decarboxylase (URO-D)] -- -- Q7TT50 Serine/threonine-protein kinase MRCK beta Cdc42bpb 2484.2 2479.2 2747.5 2743.8 2678.7 2644.9 0.955809802414656 0.271511379828789 -0.0652045315062724 Nonsignificant None 5 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468),Biological Process:intracellular signal transduction (GO:0035556) serine/threonine-protein kinase MRCK 2.7.11.1 -- Rho-associated, coiled-coil containing protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR001180[Citron homology (CNH) domain] ; IPR002219[Protein kinase C-like, phorbol ester/diacylglycerol-binding domain] ; IPR014930[Myotonic dystrophy protein kinase, coiled coil] ; IPR031597[KELK-motif containing domain] -- -- P05201 Aspartate aminotransferase, cytoplasmic Got1 2763.3 2717.8 3261.3 3100.1 3116.3 3280.9 0.920514251418824 0.241987882332237 -0.119488037307722 Nonsignificant None 2 Biological Process:biosynthetic process (GO:0009058),Molecular Function:pyridoxal phosphate binding (GO:0030170) aspartate aminotransferase, cytoplasmic 2.6.1.1 ko00220 Arginine biosynthesis ko00250 Alanine, aspartate and glutamate metabolism ko00270 Cysteine and methionine metabolism ko00330 Arginine and proline metabolism ko00350 Tyrosine metabolism ko00360 Phenylalanine metabolism ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis ko01100 Metabolic pathways ko01200 Carbon metabolism ko01210 2-Oxocarboxylic acid metabolism ko01230 Biosynthesis of amino acids Aspartate aminotransferase/Glutamic oxaloacetic transaminase AAT2/GOT1 E Amino acid transport and metabolism ; IPR004839 [Aminotransferase, class I/classII] -- -- Q61655 ATP-dependent RNA helicase DDX19A Ddx19a 217.9 217.2 222.8 178.7 201.5 193 1.14776692254013 0.0148206551766493 0.198829703132604 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase DDX19/DBP5 3.6.4.13 -- ATP-dependent RNA helicase A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR011545[DEAD/DEAH box helicase domain] -- -- Q8VDM6 Heterogeneous nuclear ribonucleoprotein U-like protein 1 Hnrnpul1 3954.6 4184.7 3098.9 3181.5 3212.3 3303.1 1.15894770493663 0.259284234090443 0.212815469251435 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) heterogeneous nuclear ribonucleoprotein U-like protein 1 -- ko05164 Influenza A Scaffold/matrix specific factor hnRNP-U/SAF-A, contains SPRY domain A RNA processing and modification ; IPR003034 [SAP domain] ; IPR003877[SPRY domain] -- -- Q9D964 Glycine amidinotransferase, mitochondrial Gatm 2584.7 2389.5 2107.9 1837.6 2161.3 1920.1 1.19650278763305 0.0835643875095158 0.258823758096375 Nonsignificant None -- -- glycine amidinotransferase 2.1.4.1 ko00260 Glycine, serine and threonine metabolism ko00330 Arginine and proline metabolism ko01100 Metabolic pathways -- -- -- -- -- -- Q8VCN5 Cystathionine gamma-lyase Cth 2424.3 2256.1 2636 3394.2 3129.3 3623.1 0.721069126603986 0.00634784561541453 -0.471790522205899 Nonsignificant None 1 Molecular Function:pyridoxal phosphate binding (GO:0030170) cystathionine gamma-lyase 4.4.1.1 ko00260 Glycine, serine and threonine metabolism ko00270 Cysteine and methionine metabolism ko00450 Selenocompound metabolism ko01100 Metabolic pathways ko01230 Biosynthesis of amino acids Cystathionine beta-lyases/cystathionine gamma-synthases E Amino acid transport and metabolism ; IPR000277 [Cys/Met metabolism, pyridoxal phosphate-dependent enzyme] -- -- A0A1S6GWH6 UBC core domain-containing protein Birc6 1170.2 1131.9 1108.4 1075.2 1037.4 1123 1.05405488935592 0.129666243272336 0.0759499965194244 Nonsignificant None 3 Molecular Function:ubiquitin-protein transferase activity (GO:0004842),Biological Process:apoptotic process (GO:0006915),Biological Process:regulation of cytokinesis (GO:0032465) baculoviral IAP repeat-containing protein 6 (apollon) 2.3.2.23 ko04120 Ubiquitin mediated proteolysis ko04215 Apoptosis - multiple species Ubiquitin-conjugating enzyme O Posttranslational modification, protein turnover, chaperones ; IPR000608 [Ubiquitin-conjugating enzyme E2] ; IPR001370[BIR repeat] ; IPR022103[Baculoviral IAP repeat-containing protein 6] -- -- Q9DBH5 Vesicular integral-membrane protein VIP36 Lman2 4052.2 4171.6 4463.1 4235.2 4303.1 4133.3 1.00120742447678 0.970951162263326 0.00174089451694965 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) lectin, mannose-binding 2 -- ko04141 Protein processing in endoplasmic reticulum Lectin VIP36, involved in the transport of glycoproteins carrying high mannose-type glycans U Intracellular trafficking, secretion, and vesicular transport ; IPR005052 [Legume-like lectin] -- -- A0A494BA97 Osteoclast-stimulating factor 1 Ostf1 2412 2562.1 2571.1 2246.1 2457.5 2355.3 1.06889175367267 0.112448096589651 0.0961157591885893 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR001452 [SH3 domain] ; IPR020683[Ankyrin repeat-containing domain] -- -- Q9JLQ0 CD2-associated protein Cd2ap 5331.1 4910.4 4427.1 4010.3 4307.7 4121.2 1.17922374429224 0.0540797863076516 0.237837479263886 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) CD2-associated protein -- ko05100 Bacterial invasion of epithelial cells Adaptor protein CMS/SETA T Signal transduction mechanisms ; IPR001452 [SH3 domain] -- -- P41241 Tyrosine-protein kinase CSK Csk 2271.1 2231 2485.7 2388.4 2363 2589.1 0.951951501941285 0.332008498208227 -0.071040018928788 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein binding (GO:0005515),Biological Process:protein phosphorylation (GO:0006468) c-src tyrosine kinase 2.7.10.2 Tyrosine kinases T Signal transduction mechanisms ; IPR000980 [SH2 domain] ; IPR001245[Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR001452[SH3 domain] -- -- D3Z7P3 Glutaminase kidney isoform, mitochondrial Gls 2380.9 2265.2 3199.2 2589.3 2652.8 2733.2 0.983699672739583 0.896877561085991 -0.0237101723956458 Nonsignificant None 2 Molecular Function:glutaminase activity (GO:0004359),Biological Process:glutamine metabolic process (GO:0006541) glutaminase 3.5.1.2 ko00220 Arginine biosynthesis ko00250 Alanine, aspartate and glutamate metabolism ko00471 D-Glutamine and D-glutamate metabolism ko01100 Metabolic pathways ko04724 Glutamatergic synapse ko04727 GABAergic synapse ko04964 Proximal tubule bicarbonate reclamation ko05206 MicroRNAs in cancer ko05230 Central carbon metabolism in cancer Glutaminase (contains ankyrin repeat) E Amino acid transport and metabolism ; IPR015868 [Glutaminase] ; IPR020683[Ankyrin repeat-containing domain] -- -- Q99L04 Dehydrogenase/reductase SDR family member 1 Dhrs1 3654.5 3641 3550.1 3840.2 3817.9 3900.4 0.938322446684258 0.00440961639166002 -0.0918443168231951 Nonsignificant None -- -- dehydrogenase/reductase SDR family member 1 1.1.-.- -- Reductases with broad range of substrate specificities R General function prediction only ; IPR002347 [Short-chain dehydrogenase/reductase SDR] -- -- Q3UXN3 Cysteine--tRNA ligase Cars 4957.1 5097.1 5087.9 4093.1 4131.6 3931.5 1.24562774551258 0.00019800333533054 0.316872984940312 Nonsignificant None -- -- cysteinyl-tRNA synthetase 6.1.1.16 ko00970 Aminoacyl-tRNA biosynthesis Cysteinyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR032678 [tRNA synthetases class I, catalytic domain] -- -- Q9CT19 Uncharacterized protein (Fragment) Hmgb2 5214.9 5550.5 5192.3 4330.4 4425.6 4372.8 1.21547285357382 0.00137476828677671 0.281517672509574 Nonsignificant None -- -- high mobility group protein B2 -- -- HMG box-containing protein R General function prediction only ; IPR009071 [High mobility group box domain] -- HMG P61202 COP9 signalosome complex subunit 2 Cops2 3057.5 3066.3 3137.7 3055.6 3109.1 3120.8 0.997415324969038 0.816950027693825 -0.00373372516388116 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) COP9 signalosome complex subunit 2 -- -- COP9 signalosome, subunit CSN2 OT Posttranslational modification, protein turnover, chaperones ; Signal transduction mechanisms ; IPR000717 [Proteasome component (PCI) domain] -- -- Q9JHJ0 Tropomodulin-3 Tmod3 5084.8 5418.3 5206.9 5183.6 5284.4 5235.5 1.00041392046359 0.984018596118951 0.000597037445659354 Nonsignificant None 2 Molecular Function:tropomyosin binding (GO:0005523),Biological Process:pointed-end actin filament capping (GO:0051694) tropomodulin -- -- Tropomodulin and leiomodulin Z Cytoskeleton ; IPR004934 [Tropomodulin] -- -- Q3TJA2 Superoxide dismutase Sod2 2649.9 2871.1 3404.7 4008.5 3862.4 3857.5 0.761033047986085 0.0152000075577949 -0.39396899052726 Nonsignificant None 4 Molecular Function:superoxide dismutase activity (GO:0004784),Biological Process:superoxide metabolic process (GO:0006801),Molecular Function:metal ion binding (GO:0046872),Biological Process:oxidation-reduction process (GO:0055114) superoxide dismutase, Fe-Mn family 1.15.1.1 ko04068 FoxO signaling pathway ko04146 Peroxisome ko04211 Longevity regulating pathway ko04213 Longevity regulating pathway - multiple species ko05016 Huntington's disease Manganese superoxide dismutase P Inorganic ion transport and metabolism ; IPR019831 [Manganese/iron superoxide dismutase, N-terminal] ; IPR019832[Manganese/iron superoxide dismutase, C-terminal] -- -- Q8BTX6 Uncharacterized protein (Fragment) Mtrex 2247.8 2280.6 2462.3 2300.7 2322.7 2317.2 1.00721839610408 0.826117932318379 0.0103765381752905 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase DOB1 3.6.4.13 ko03018 RNA degradation Nuclear exosomal RNA helicase MTR4, DEAD-box superfamily A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR011545[DEAD/DEAH box helicase domain] ; IPR012961[ATP-dependent RNA helicase Ski2, C-terminal] ; IPR025696[rRNA-processing arch domain] -- -- P62843 40S ribosomal protein S15 Rps15 4274.5 4104.2 3719.1 3125.8 3269.2 3236.9 1.2560138705759 0.00841646122565958 0.328852396475216 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S15e -- ko03010 Ribosome 40S ribosomal protein S15 J Translation, ribosomal structure and biogenesis ; IPR002222 [Ribosomal protein S19/S15] -- -- Q3UDH4 Uncharacterized protein (Fragment) Sec24b 1235.6 1368.2 1426.8 1492.9 1548.2 1476.7 0.89215990083669 0.0551249994345437 -0.164625788923508 Nonsignificant None 4 Biological Process:intracellular protein transport (GO:0006886),Biological Process:ER to Golgi vesicle-mediated transport (GO:0006888),Molecular Function:zinc ion binding (GO:0008270),Cellular Component:COPII vesicle coat (GO:0030127) protein transport protein SEC24 -- ko04141 Protein processing in endoplasmic reticulum Vesicle coat complex COPII, subunit SEC24/subunit SFB2 U Intracellular trafficking, secretion, and vesicular transport ; IPR006895 [Zinc finger, Sec23/Sec24-type] ; IPR006896[Sec23/Sec24, trunk domain] ; IPR006900[Sec23/Sec24, helical domain] ; IPR007123[Gelsolin-like domain] ; IPR012990[Sec23/Sec24 beta-sandwich] -- -- Q91XD2 LIM and senescent cell antigen-like-containing domain protein 2 Lims2 1095.7 1151.1 1059.5 1416.6 1400.8 1407.1 0.78264883418156 0.000346679491202627 -0.353562963394466 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) -- -- -- Focal adhesion protein PINCH-1, contains LIM domains TZ Signal transduction mechanisms ; Cytoskeleton ; IPR001781 [Zinc finger, LIM-type] -- -- G3X8U3 Queuosine salvage protein 2210016F16Rik 2205.7 2065.2 1938.9 2147.8 2148.2 2187.8 0.95774083099417 0.307634704047575 -0.0622927859245141 Nonsignificant None -- -- -- -- -- Cobyrinic acid a,c-diamide synthase H Coenzyme transport and metabolism ; IPR019438 [Potential Queuosine, Q, salvage protein family] -- -- Q9Z2T6 Keratin, type II cuticular Hb5 Krt85 85.5 78.6 79.7 75.3 86.7 86.4 0.981481481481482 0.74048504885523 -0.0269670476002693 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) type II keratin, basic -- -- -- -- -- IPR001664 [Intermediate filament protein] ; IPR032444[Keratin type II head] -- -- P09041 Phosphoglycerate kinase 2 Pgk2 122.5 197.3 114 346.4 368.7 196.4 0.475918815139879 0.0573463064158527 -1.07121260325422 Nonsignificant None 2 Molecular Function:phosphoglycerate kinase activity (GO:0004618),Biological Process:glycolytic process (GO:0006096) phosphoglycerate kinase 2.7.2.3 ko00010 Glycolysis / Gluconeogenesis ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids 3-phosphoglycerate kinase G Carbohydrate transport and metabolism ; IPR001576 [Phosphoglycerate kinase] -- -- P21279 Guanine nucleotide-binding protein G(q) subunit alpha Gnaq 2378.9 2255.4 1826.3 2528.4 2696.4 2475.4 0.839017168385237 0.0836019798150909 -0.253227762779088 Nonsignificant None 5 Molecular Function:GTPase activity (GO:0003924),Molecular Function:signal transducer activity (GO:0004871),Biological Process:G-protein coupled receptor signaling pathway (GO:0007186),Molecular Function:guanyl nucleotide binding (GO:0019001),Molecular Function:G-protein beta/gamma-subunit complex binding (GO:0031683) guanine nucleotide-binding protein G(q) subunit alpha -- ko04015 Rap1 signaling pathway ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04071 Sphingolipid signaling pathway ko04261 Adrenergic signaling in cardiomyocytes ko04270 Vascular smooth muscle contraction ko04371 Apelin signaling pathway ko04540 Gap junction ko04611 Platelet activation ko04713 Circadian entrainment ko04720 Long-term potentiation ko04723 Retrograde endocannabinoid signaling ko04724 Glutamatergic synapse ko04725 Cholinergic synapse ko04726 Serotonergic synapse ko04728 Dopaminergic synapse ko04730 Long-term depression ko04750 Inflammatory mediator regulation of TRP channels ko04911 Insulin secretion ko04912 GnRH signaling pathway ko04915 Estrogen signaling pathway ko04916 Melanogenesis ko04918 Thyroid hormone synthesis ko04921 Oxytocin signaling pathway ko04922 Glucagon signaling pathway ko04924 Renin secretion ko04925 Aldosterone synthesis and secretion ko04961 Endocrine and other factor-regulated calcium reabsorption ko04970 Salivary secretion ko04971 Gastric acid secretion ko04972 Pancreatic secretion ko05010 Alzheimer's disease ko05016 Huntington's disease ko05142 Chagas disease (American trypanosomiasis) ko05143 African trypanosomiasis ko05146 Amoebiasis ko05200 Pathways in cancer G protein subunit Galphaq/Galphay, small G protein superfamily T Signal transduction mechanisms ; IPR001019 [Guanine nucleotide binding protein (G-protein), alpha subunit] -- -- O08807 Peroxiredoxin-4 Prdx4 2217.1 2228.7 1901.3 1609.5 1745.3 1647.9 1.26873488316309 0.0173951803465464 0.343390632847121 Nonsignificant None 4 Molecular Function:antioxidant activity (GO:0016209),Molecular Function:oxidoreductase activity (GO:0016491),Molecular Function:peroxiredoxin activity (GO:0051920),Biological Process:oxidation-reduction process (GO:0055114) peroxiredoxin (alkyl hydroperoxide reductase subunit C) 1.11.1.15 Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes O Posttranslational modification, protein turnover, chaperones ; IPR000866 [Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant] ; IPR019479[Peroxiredoxin, C-terminal] -- -- P29452 Caspase-1 Casp1 3635.7 3394.6 4379 4399.4 4668 4268.9 0.855507149659201 0.114074619383922 -0.225148183206255 Nonsignificant None 1 Biological Process:regulation of apoptotic process (GO:0042981) caspase 1 3.4.22.36 ko04217 Necroptosis ko04621 NOD-like receptor signaling pathway ko04623 Cytosolic DNA-sensing pathway ko05014 Amyotrophic lateral sclerosis (ALS) ko05132 Salmonella infection ko05133 Pertussis ko05134 Legionellosis ko05164 Influenza A Caspase, apoptotic cysteine protease D Cell cycle control, cell division, chromosome partitioning ; IPR001315 [CARD domain] -- -- A0A0G2JF67 Phosphodiesterase Pde5a 2515.5 2647 2747.5 3052.7 3019.1 2972.1 0.87462267384646 0.0060285987967516 -0.193267345345633 Nonsignificant None 3 Molecular Function:3',5'-cyclic-nucleotide phosphodiesterase activity (GO:0004114),Molecular Function:protein binding (GO:0005515),Biological Process:signal transduction (GO:0007165) cGMP-specific 3',5'-cyclic phosphodiesterase 3.1.4.35 ko00230 Purine metabolism ko04022 cGMP-PKG signaling pathway Cyclic nucleotide phosphodiesterase T Signal transduction mechanisms ; IPR002073 [3'5'-cyclic nucleotide phosphodiesterase, catalytic domain] ; IPR003018[GAF domain] -- -- Q9QY23 Plakophilin-3 Pkp3 2907.2 2717.6 2689.3 2883 2920.5 2800.9 0.966261447631445 0.277160993520537 -0.0495144936446691 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Neural adherens junction protein Plakophilin and related Armadillo repeat proteins TW Signal transduction mechanisms ; Extracellular structures ; IPR000225 [Armadillo] -- -- P35235 Tyrosine-protein phosphatase non-receptor type 11 Ptpn11 2350.5 2375.9 2843.4 2790.6 2530.6 2483.1 0.969952462104225 0.696763214655926 -0.044014053120689 Nonsignificant None 2 Molecular Function:protein tyrosine phosphatase activity (GO:0004725),Biological Process:protein dephosphorylation (GO:0006470) tyrosine-protein phosphatase non-receptor type 11 3.1.3.48 ko04014 Ras signaling pathway ko04072 Phospholipase D signaling pathway ko04360 Axon guidance ko04630 Jak-STAT signaling pathway ko04650 Natural killer cell mediated cytotoxicity ko04670 Leukocyte transendothelial migration ko04722 Neurotrophin signaling pathway ko04920 Adipocytokine signaling pathway ko04931 Insulin resistance ko05168 Herpes simplex infection ko05205 Proteoglycans in cancer ko05211 Renal cell carcinoma ko05220 Chronic myeloid leukemia Protein tyrosine phosphatase Corkscrew and related SH2 domain enzymes T Signal transduction mechanisms ; IPR000242 [PTP type protein phosphatase] ; IPR000980[SH2 domain] -- -- Q8CBM0 Uncharacterized protein Zyx 4483 5138.8 3773.2 3388.1 3468.8 3304.3 1.31824981301421 0.109774004087661 0.398623792080165 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) zyxin -- ko04510 Focal adhesion Focal adhesion adaptor protein Paxillin and related LIM proteins T Signal transduction mechanisms ; IPR001781 [Zinc finger, LIM-type] -- -- Q61553 Fascin Fscn1 2906.2 2721.4 2863.2 2582.6 2692.5 2631.7 1.07386047452825 0.0387773565526546 0.102806557771682 Nonsignificant None 1 Molecular Function:actin filament binding (GO:0051015) fascin 1/2 -- -- -- -- -- IPR022768 [Fascin domain] -- -- Q5SSH7 Zinc finger ZZ-type and EF-hand domain-containing protein 1 Zzef1 1926.3 1877.5 1971.9 2044.4 2170.1 2005.8 0.928524347700272 0.0588899489239407 -0.106988353982568 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) -- -- -- -- -- -- IPR000433 [Zinc finger, ZZ-type] ; IPR004939[APC10/DOC domain] -- -- P61164 Alpha-centractin Actr1a 971.9 1016.1 833.9 840 842.4 965 1.06591372667523 0.444614113604851 0.0920906734303771 Nonsignificant None -- -- centractin -- -- Actin and related proteins Z Cytoskeleton ; IPR004000 [Actin family] -- -- P61358 60S ribosomal protein L27 Rpl27 6236.3 5854.7 4825.5 4335.5 4293.5 4246.4 1.31386209360486 0.0849299466170602 0.393813854569277 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L27e -- ko03010 Ribosome 60S ribosomal protein L27 J Translation, ribosomal structure and biogenesis ; IPR001141 [Ribosomal protein L27e] ; IPR005824[KOW] -- -- Q497E1 40S ribosomal protein S23 Rps23 6374.4 5068.7 4423.5 4069.3 4176.5 4299.3 1.26476472885828 0.192009966983302 0.338869040194457 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S23e -- ko03010 Ribosome 40S ribosomal protein S23 J Translation, ribosomal structure and biogenesis ; IPR006032 [Ribosomal protein S12/S23] -- -- G3X956 FACT complex subunit Supt16 5932.1 5806.2 6114.4 5128.7 5256 5284 1.13938616477436 0.00199550034473043 0.188256793212897 Nonsignificant None -- -- -- -- -- Global transcriptional regulator, cell division control protein E Amino acid transport and metabolism ; IPR000994 [Peptidase M24] ; IPR013719[Domain of unknown function DUF1747] ; IPR013953[FACT complex subunit Spt16p/Cdc68p] ; IPR029148[FACT complex subunit Spt16, N-terminal lobe domain] -- -- Q544F6 Cotl1 protein Cotl1 5190.9 5244.6 4985.4 4493.1 4798.4 4699.5 1.10220141519548 0.0163733812563752 0.140387884663926 Nonsignificant None 2 Molecular Function:actin binding (GO:0003779),Cellular Component:intracellular (GO:0005622) -- -- -- Drebrins and related actin binding proteins Z Cytoskeleton ; IPR002108 [Actin-depolymerising factor homology domain] -- -- Q61823 Programmed cell death protein 4 Pdcd4 2328.3 2060.4 2537.9 3120.7 2746.8 3011.8 0.780084015631863 0.0213542884165596 -0.358298583209829 Nonsignificant None -- -- programmed cell death protein 4 -- ko05205 Proteoglycans in cancer ko05206 MicroRNAs in cancer Neoplastic transformation suppressor Pdcd4/MA-3, contains MA3 domain T Signal transduction mechanisms ; IPR003891 [Initiation factor eIF-4 gamma, MA3] -- -- Q99JW2 Aminoacylase-1 Acy1 19.5 18.7 20.9 32.6 35.5 37.3 0.560721062618596 0.000519792836361809 -0.834644831459682 Significant down 2 Biological Process:metabolic process (GO:0008152),Molecular Function:hydrolase activity (GO:0016787) aminoacylase 3.5.1.14 ko00220 Arginine biosynthesis ko01100 Metabolic pathways ko01210 2-Oxocarboxylic acid metabolism ko01230 Biosynthesis of amino acids Aminoacylase ACY1 and related metalloexopeptidases E Amino acid transport and metabolism ; IPR002933 [Peptidase M20] ; IPR011650[Peptidase M20, dimerisation domain] -- -- A5GZX3 Lactoylglutathione lyase Glo1 6009.8 5821.7 5593.7 4558.6 7771.2 6323.1 0.934181816232328 0.703597641760614 -0.0982247314092439 Nonsignificant None -- -- lactoylglutathione lyase 4.4.1.5 ko00620 Pyruvate metabolism Glyoxalase G Carbohydrate transport and metabolism ; IPR004360 [Glyoxalase/fosfomycin resistance/dioxygenase domain] -- -- A0A1Y7VJ48 Tubulin-specific chaperone A Tbca 3457.4 3272.8 3415.5 2934.1 2886.1 3049.8 1.14382187147689 0.00455552901547664 0.19386239726825 Nonsignificant None 3 Biological Process:tubulin complex assembly (GO:0007021),Biological Process:post-chaperonin tubulin folding pathway (GO:0007023),Molecular Function:beta-tubulin binding (GO:0048487) tubulin-specific chaperone A -- -- Beta-tubulin folding cofactor A O Posttranslational modification, protein turnover, chaperones ; IPR004226 [Tubulin binding cofactor A] -- -- Q91YR9 Prostaglandin reductase 1 Ptgr1 2150.6 2008.4 1982.1 2073.7 2086.2 2219.8 0.962600122262802 0.320421043383426 -0.0549914883434308 Nonsignificant None 1 Biological Process:oxidation-reduction process (GO:0055114) -- -- -- Predicted NAD-dependent oxidoreductase R General function prediction only ; IPR013149 [Alcohol dehydrogenase, C-terminal] -- -- Q3UP61 Uncharacterized protein Dlg1 2190.1 2093.4 2149.4 2472.2 2482.2 2360 0.879484304932736 0.00365397613042037 -0.185270262952207 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) disks large protein 1 -- ko04390 Hippo signaling pathway ko04530 Tight junction ko04660 T cell receptor signaling pathway ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05203 Viral carcinogenesis Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) F Nucleotide transport and metabolism ; IPR001452 [SH3 domain] ; IPR001478[PDZ domain] ; IPR008145[Guanylate kinase/L-type calcium channel beta subunit] ; IPR015143[L27-1] ; IPR019583[PDZ-associated domain of NMDA receptors] ; IPR019590[Disks large homologue 1, N-terminal PEST domain] -- -- Q3TE95 Uncharacterized protein Rcn2 1821.3 1786.1 1804.6 1921.7 1813.2 1824.6 0.973468837125641 0.242615488473077 -0.0387932990377355 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) -- -- -- Reticulocalbin, calumenin, DNA supercoiling factor, and related Ca2+-binding proteins of the CREC family (EF-Hand protein superfamily) TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR002048 [EF-hand domain] -- -- P55292 Desmocollin-2 Dsc2 3508.7 3410.7 3468.8 3394.2 3510.6 3415.3 1.0065987732677 0.645682176209857 0.00948874474987366 Nonsignificant None 3 Molecular Function:calcium ion binding (GO:0005509),Biological Process:homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156),Cellular Component:membrane (GO:0016020) desmocollin 2 -- ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) FOG: Cadherin repeats S Function unknown ; IPR000233 [Cadherin, cytoplasmic domain] ; IPR002126[Cadherin] ; IPR014868[Cadherin prodomain] -- -- Q3TGE4 Protein kinase C delta type Prkcd 2275.2 2239.9 2231.8 2619.6 2622.4 2481.6 0.873543425345694 0.0025335770837014 -0.195048671111501 Nonsignificant None 5 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468),Biological Process:intracellular signal transduction (GO:0035556) novel protein kinase C delta type 2.7.11.13 ko04062 Chemokine signaling pathway ko04140 Autophagy - animal ko04270 Vascular smooth muscle contraction ko04621 NOD-like receptor signaling pathway ko04666 Fc gamma R-mediated phagocytosis ko04722 Neurotrophin signaling pathway ko04750 Inflammatory mediator regulation of TRP channels ko04912 GnRH signaling pathway ko04915 Estrogen signaling pathway ko04930 Type II diabetes mellitus ko04931 Insulin resistance ko04933 AGE-RAGE signaling pathway in diabetic complications Serine/threonine protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR002219[Protein kinase C-like, phorbol ester/diacylglycerol-binding domain] ; IPR017892[Protein kinase, C-terminal] -- -- Q8VEH3 ADP-ribosylation factor-like protein 8A Arl8a 239 255.9 352 348.6 373.5 390.4 0.761258426966292 0.0761277170888563 -0.393541801457636 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) ADP-ribosylation factor-like protein 8 -- -- GTP-binding ADP-ribosylation factor-like protein R General function prediction only ; IPR006689 [Small GTPase superfamily, ARF/SAR type] -- -- Q3TN07 Vesicle-fusing ATPase Vps4b 1595 1550.6 1552.6 1710.2 1732.4 1651 0.922373174179362 0.00958676845367736 -0.116577539878145 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) vacuolar protein-sorting-associated protein 4 -- ko04144 Endocytosis ko04217 Necroptosis AAA+-type ATPase O Posttranslational modification, protein turnover, chaperones ; IPR003959 [ATPase, AAA-type, core] ; IPR007330[MIT] ; IPR015415[Vps4 oligomerisation, C-terminal] -- -- Q5SUR0 Phosphoribosylformylglycinamidine synthase Pfas 2461.9 2349.7 2314.8 2351.3 2372 2320.1 1.01178408155152 0.586727669153906 0.016901446444683 Nonsignificant None -- -- phosphoribosylformylglycinamidine synthase 6.3.5.3 ko00230 Purine metabolism ko01100 Metabolic pathways Phosphoribosylformylglycinamidine synthase F Nucleotide transport and metabolism ; IPR010918 [AIR synthase-related protein, C-terminal domain] -- -- Q8BTI8 Serine/arginine repetitive matrix protein 2 Srrm2 2814.4 2800.2 2997 2365.2 2359.8 2331.2 1.22043025991327 0.00128012236361922 0.287389856321892 Nonsignificant None -- -- serine/arginine repetitive matrix protein 2 -- -- Splicing coactivator SRm160/300, subunit SRm300 A RNA processing and modification ; IPR013170 [mRNA splicing factor Cwf21 domain] -- -- Q8BFY6 Peflin Pef1 1681.9 1582.5 1788.1 1848.6 1932.8 1830.2 0.900367096728206 0.0502481263032477 -0.151414759390722 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) -- -- -- Ca2+-binding protein, EF-Hand protein superfamily T Signal transduction mechanisms ; IPR002048 [EF-hand domain] -- -- Q5UE59 Kinesin light chain Klc1 2387.9 2358.9 2445.3 2429.5 2704.3 2586.5 0.931582969573721 0.102791577627715 -0.102243829250259 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) kinesin light chain -- ko05132 Salmonella infection Kinesin light chain Z Cytoskeleton ; IPR011990 [Tetratricopeptide-like helical domain] -- -- B2CQD6 Fibulin-1 Fbln1 2607.9 2998 3328.6 3258.1 2978.1 2817 0.986888613970751 0.87949563314759 -0.0190408320296317 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) fibulin 1/2 -- -- Fibrillins and related proteins containing Ca2+-binding EGF-like domains T Signal transduction mechanisms ; IPR001881 [EGF-like calcium-binding domain] ; IPR026823[Complement Clr-like EGF domain] -- -- O35857 Mitochondrial import inner membrane translocase subunit TIM44 Timm44 3269.3 3079.9 3611.9 3403.4 3332.1 3423.6 0.980510084554734 0.697844422481682 -0.0283956262626088 Nonsignificant None -- -- mitochondrial import inner membrane translocase subunit TIM44 -- -- Mitochondrial import inner membrane translocase, subunit TIM44 U Intracellular trafficking, secretion, and vesicular transport ; IPR007379 [Tim44-like domain] -- -- Q5HZI6 GDP-L-fucose synthase Gfus 1527.6 1527.6 1726.8 1933.5 1935.7 1958.1 0.82062018430491 0.0329204323946468 -0.285213455111615 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Molecular Function:coenzyme binding (GO:0050662) GDP-L-fucose synthase 1.1.1.271 ko00051 Fructose and mannose metabolism ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways GDP-L-fucose synthetase GO Carbohydrate transport and metabolism ; Posttranslational modification, protein turnover, chaperones ; IPR001509 [NAD-dependent epimerase/dehydratase] -- -- P62320 Small nuclear ribonucleoprotein Sm D3 Snrpd3 1539 1691.2 1801.8 1689.9 1790.5 1594.8 0.991488020176545 0.886674794381346 -0.012332753937327 Nonsignificant None -- -- small nuclear ribonucleoprotein D3 -- ko03040 Spliceosome ko05322 Systemic lupus erythematosus Small nuclear ribonucleoprotein Sm D3 A RNA processing and modification ; IPR001163 [LSM domain, eukaryotic/archaea-type] -- -- P02463 Collagen alpha-1(IV) chain Col4a1 1465.6 1451.9 1667.2 1632.5 1798.1 1625.3 0.906801954152574 0.154492020082889 -0.141140594806469 Nonsignificant None 2 Molecular Function:extracellular matrix structural constituent (GO:0005201),Cellular Component:collagen trimer (GO:0005581) collagen, type IV, alpha -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04926 Relaxin signaling pathway ko04933 AGE-RAGE signaling pathway in diabetic complications ko04974 Protein digestion and absorption ko05146 Amoebiasis ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05222 Small cell lung cancer Collagens (type IV and type XIII), and related proteins W Extracellular structures ; IPR001442 [Collagen IV, non-collagenous] ; IPR008160[Collagen triple helix repeat] -- -- Q99LD8 N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 Ddah2 2369.8 2460.6 2804.4 2963.2 2933.4 2975.5 0.86054034557771 0.0881050487208271 -0.216685261714982 Nonsignificant None -- -- dimethylargininase 3.5.3.18 -- -- -- -- -- -- -- Q91WP6 Serine protease inhibitor A3N Serpina3n 3654.8 3594.3 2948.9 1768.5 1899.8 2031.6 1.78915419568764 0.00326086836776594 0.839277729350431 Significant up -- -- serpin peptidase inhibitor, clade A -- -- Serpin V Defense mechanisms ; IPR023796 [Serpin domain] -- -- P27661 Histone H2AX H2ax 457.9 490.2 994.6 1023.3 909.7 881.8 0.690173369333523 0.179836340269075 -0.534969287111729 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) histone H2A -- ko04217 Necroptosis ko05034 Alcoholism ko05322 Systemic lupus erythematosus Histone 2A B Chromatin structure and dynamics ; IPR007125 [Histone H2A/H2B/H3] ; IPR032454[Histone H2A, C-terminal domain] -- -- Q8BJY1 26S proteasome non-ATPase regulatory subunit 5 Psmd5 2444.2 2438.8 2278.3 2239.2 2210.8 2290.4 1.06244436531957 0.0768153666869123 0.0873872967994891 Nonsignificant None 1 Biological Process:proteasome assembly (GO:0043248) 26S proteasome non-ATPase regulatory subunit 5 -- -- 26S proteasome regulatory complex, subunit PSMD5 O Posttranslational modification, protein turnover, chaperones ; IPR019538 [26S proteasome non-ATPase regulatory subunit 5] -- -- O08583 THO complex subunit 4 Alyref 1182.8 1193.7 1353.2 1474.2 1493.7 1395.3 0.854808397506417 0.0281729616738486 -0.226327014005507 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) THO complex subunit 4 -- ko03013 RNA transport ko03015 mRNA surveillance pathway ko03040 Spliceosome ko05168 Herpes simplex infection RRM motif-containing protein A RNA processing and modification ; IPR000504 [RNA recognition motif domain] ; IPR025715[Chromatin target of PRMT1 protein, C-terminal] -- -- Q60960 Importin subunit alpha-5 Kpna1 179 186.4 216.8 206 244 203.7 0.890622609759829 0.243759133014521 -0.167113857714297 Nonsignificant None 5 Molecular Function:protein binding (GO:0005515),Cellular Component:nucleus (GO:0005634),Cellular Component:cytoplasm (GO:0005737),Biological Process:protein import into nucleus (GO:0006606),Molecular Function:protein transporter activity (GO:0008565) importin subunit alpha-1 -- ko05164 Influenza A Karyopherin (importin) alpha U Intracellular trafficking, secretion, and vesicular transport ; IPR000225 [Armadillo] ; IPR002652[Importin-alpha, importin-beta-binding domain] ; IPR032413[Atypical Arm repeat] -- -- Q3UQ28 Peroxidasin homolog Pxdn 2957.9 2912.8 2829.1 2712.8 2731.3 2708.8 1.06708042537011 0.00895946819465736 0.0936689155343879 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) peroxidase 1.11.1.7 -- Peroxidase/oxygenase R General function prediction only ; IPR001007 [VWFC domain] ; IPR001611[Leucine-rich repeat] ; IPR013098[Immunoglobulin I-set] ; IPR019791[Haem peroxidase, animal] -- -- W5XQG0 MHC class I antigen H2-D1 2145.6 2266.1 2048.3 1987.6 2160.6 2074.1 1.03820130819793 0.380107832971121 0.0540862107286071 Nonsignificant None 2 Biological Process:immune response (GO:0006955),Biological Process:antigen processing and presentation (GO:0019882) major histocompatibility complex, class I -- ko04144 Endocytosis ko04145 Phagosome ko04218 Cellular senescence ko04514 Cell adhesion molecules (CAMs) ko04612 Antigen processing and presentation ko04940 Type I diabetes mellitus ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis ko05320 Autoimmune thyroid disease ko05330 Allograft rejection ko05332 Graft-versus-host disease ko05416 Viral myocarditis -- -- -- IPR003597 [Immunoglobulin C1-set] ; IPR010579[MHC class I, alpha chain, C-terminal] ; IPR011161[MHC class I-like antigen recognition-like] -- -- Q91YP3 Deoxyribose-phosphate aldolase Dera 1819.4 1844.8 2131.3 2006.6 2077.8 2007.1 0.951407699253058 0.391349615546024 -0.0718643945509846 Nonsignificant None 1 Molecular Function:lyase activity (GO:0016829) deoxyribose-phosphate aldolase 4.1.2.4 ko00030 Pentose phosphate pathway Deoxyribose-phosphate aldolase F Nucleotide transport and metabolism ; IPR002915 [DeoC/FbaB/ lacD aldolase] -- -- P39053 Dynamin-1 Dnm1 465 434.2 463.2 493.3 514.8 508.8 0.898147537741446 0.0122264912925013 -0.154975640472735 Nonsignificant None 2 Molecular Function:GTPase activity (GO:0003924),Molecular Function:GTP binding (GO:0005525) dynamin GTPase 3.6.5.5 ko04072 Phospholipase D signaling pathway ko04144 Endocytosis ko04721 Synaptic vesicle cycle ko04961 Endocrine and other factor-regulated calcium reabsorption ko05100 Bacterial invasion of epithelial cells Vacuolar sorting protein VPS1, dynamin, and related proteins UR Intracellular trafficking, secretion, and vesicular transport ; General function prediction only ; IPR000375 [Dynamin central domain] ; IPR001849[Pleckstrin homology domain] ; IPR003130[Dynamin GTPase effector] ; IPR022812[Dynamin superfamily] -- -- Q3TN84 Procollagen-proline 4-dioxygenase P4ha1 2942.2 2845.9 3104.2 3010.2 2999.6 2862.1 1.00229939471816 0.942888119300174 0.00331351727313456 Nonsignificant None 4 Molecular Function:procollagen-proline 4-dioxygenase activity (GO:0004656),Cellular Component:endoplasmic reticulum (GO:0005783),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) prolyl 4-hydroxylase 1.14.11.2 ko00330 Arginine and proline metabolism ko01100 Metabolic pathways Prolyl 4-hydroxylase alpha subunit E Amino acid transport and metabolism ; IPR005123 [Oxoglutarate/iron-dependent dioxygenase] ; IPR013547[Prolyl 4-hydroxylase alpha-subunit, N-terminal] -- -- Q8BKG3 Inactive tyrosine-protein kinase 7 Ptk7 2240.8 2275.9 2597 2449.9 2383.2 2423.6 0.980294073063514 0.699741309398915 -0.0287134945282473 Nonsignificant None 2 Molecular Function:protein kinase activity (GO:0004672),Biological Process:protein phosphorylation (GO:0006468) PTK7 protein tyrosine kinase 7 2.7.10.1 -- FOG: Immunoglobin and related proteins RP General function prediction only ; Inorganic ion transport and metabolism ; IPR001245 [Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR013098[Immunoglobulin I-set] -- -- O35206 Collagen alpha-1(XV) chain Col15a1 3375.2 3462.1 3527.8 3779.3 3946.1 3698.6 0.907309173669468 0.0143591977144025 -0.140333849189279 Nonsignificant None 3 Molecular Function:structural molecule activity (GO:0005198),Biological Process:cell adhesion (GO:0007155),Cellular Component:extracellular matrix (GO:0031012) collagen, type XV, alpha -- ko04974 Protein digestion and absorption Collagens (type XV) W Extracellular structures ; IPR008160 [Collagen triple helix repeat] ; IPR010515[Collagenase NC10/endostatin] -- -- S4R2F3 Ankyrin-2 Ank2 1861.9 1938.6 2284 2433.6 2359.5 2349.5 0.851860666984011 0.0562804477962832 -0.231310616888867 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Biological Process:signal transduction (GO:0007165) ankyrin -- ko05205 Proteoglycans in cancer Ankyrin M Cell wall/membrane/envelope biogenesis ; IPR000488 [Death domain] ; IPR000906[ZU5 domain] ; IPR002110[Ankyrin repeat] ; IPR020683[Ankyrin repeat-containing domain] -- -- Q9DBH1 Uncharacterized protein Ubtf 3231.4 3217.9 3547.1 3132.1 3225.9 3228.8 1.04272541411107 0.290336663391336 0.0603592960600836 Nonsignificant None -- -- upstream-binding transcription factor -- -- HMG box-containing protein R General function prediction only ; IPR009071 [High mobility group box domain] ; IPR029215[High mobility group box domain 5] -- HMG P61089 Ubiquitin-conjugating enzyme E2 N Ube2n 3933 4170.9 3311.1 3600.2 3596 3751.7 1.04266571671279 0.583465148995729 0.060276697511355 Nonsignificant None -- -- -- -- -- Ubiquitin-protein ligase O Posttranslational modification, protein turnover, chaperones ; IPR000608 [Ubiquitin-conjugating enzyme E2] -- -- O70503 Very-long-chain 3-oxoacyl-CoA reductase Hsd17b12 4228.7 4269.9 3983.9 3582.9 3678 3758.4 1.13278520414182 0.00896669240080052 0.179874326915416 Nonsignificant None -- -- -- -- ko00062 Fatty acid elongation ko00140 Steroid hormone biosynthesis ko01040 Biosynthesis of unsaturated fatty acids ko01100 Metabolic pathways ko01212 Fatty acid metabolism 17 beta-hydroxysteroid dehydrogenase type 3, HSD17B3 I Lipid transport and metabolism ; IPR002347 [Short-chain dehydrogenase/reductase SDR] -- -- Q9QXK3 Coatomer subunit gamma-2 Copg2 1710.6 1714.3 1799.4 1912.5 1935.7 1985 0.895614756908729 0.00488585884724731 -0.159049795433288 Nonsignificant None 5 Molecular Function:structural molecule activity (GO:0005198),Biological Process:intracellular protein transport (GO:0006886),Biological Process:vesicle-mediated transport (GO:0016192),Cellular Component:membrane coat (GO:0030117),Cellular Component:COPI vesicle coat (GO:0030126) coatomer subunit gamma -- -- Vesicle coat complex COPI, gamma subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR002553 [Clathrin/coatomer adaptor, adaptin-like, N-terminal] ; IPR013040[Coatomer, gamma subunit, appendage, Ig-like subdomain] ; IPR032154[Coatomer subunit gamma, C-terminal] -- -- Q9CX86 Heterogeneous nuclear ribonucleoprotein A0 Hnrnpa0 2684.3 2751.2 2562.4 2488.5 2483.1 2484.2 1.07270849539955 0.0820486151342266 0.101258082265872 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) heterogeneous nuclear ribonucleoprotein A0 -- -- FOG: RRM domain R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- G5E8V9 Arfaptin-1 Arfip1 3206 3148 3304.2 3093.2 3190.8 3041.1 1.03572079655982 0.154130002170287 0.0506351423038031 Nonsignificant None 1 Molecular Function:protein domain specific binding (GO:0019904) arfaptin -- -- Arfaptin and related proteins T Signal transduction mechanisms ; IPR010504 [Arfaptin homology (AH) domain] -- -- Q3UPH1 Protein PRRC1 Prrc1 1758.1 1797.4 1964.5 1967.1 2036.2 1981.1 0.922398235412071 0.0810551166552232 -0.116538341833377 Nonsignificant None -- -- -- -- -- -- -- -- IPR026533 [Non-canonical purine NTP phosphatase/PRRC1] -- -- Q8BM84 ELAV-like protein Elavl1 4174 4140.5 4509 4159.1 4140.4 4165.1 1.02879354331467 0.416252759654607 0.0409534934850096 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) ELAV-like protein 1 -- ko04152 AMPK signaling pathway ko04657 IL-17 signaling pathway RNA-binding protein ELAV/HU (RRM superfamily) A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- P84244 Histone H3.3 H3-3a 703.3 675 760.2 782.2 680.1 954 0.885030832264206 0.330902135055892 -0.176200378923539 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) histone H3 -- ko05034 Alcoholism ko05202 Transcriptional misregulation in cancer ko05322 Systemic lupus erythematosus Histones H3 and H4 B Chromatin structure and dynamics ; IPR007125 [Histone H2A/H2B/H3] -- -- Q91YS7 Dual-specificity mitogen-activated protein kinase kinase 2 Map2k2 1771.9 1792.5 2108.2 2048.3 2123.2 1879.9 0.937402915027927 0.38792009173605 -0.0932588137361006 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) mitogen-activated protein kinase kinase 2 2.7.12.2 ko01521 EGFR tyrosine kinase inhibitor resistance ko01522 Endocrine resistance ko04010 MAPK signaling pathway ko04012 ErbB signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04066 HIF-1 signaling pathway ko04068 FoxO signaling pathway ko04071 Sphingolipid signaling pathway ko04072 Phospholipase D signaling pathway ko04140 Autophagy - animal ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04210 Apoptosis ko04218 Cellular senescence ko04270 Vascular smooth muscle contraction ko04370 VEGF signaling pathway ko04371 Apelin signaling pathway ko04540 Gap junction ko04550 Signaling pathways regulating pluripotency of stem cells ko04620 Toll-like receptor signaling pathway ko04650 Natural killer cell mediated cytotoxicity ko04660 T cell receptor signaling pathway ko04662 B cell receptor signaling pathway ko04664 Fc epsilon RI signaling pathway ko04720 Long-term potentiation ko04722 Neurotrophin signaling pathway ko04730 Long-term depression ko04810 Regulation of actin cytoskeleton ko04910 Insulin signaling pathway ko04912 GnRH signaling pathway ko04915 Estrogen signaling pathway ko04916 Melanogenesis ko04917 Prolactin signaling pathway ko04919 Thyroid hormone signaling pathway ko04921 Oxytocin signaling pathway ko04926 Relaxin signaling pathway ko05020 Prion diseases ko05161 Hepatitis B ko05164 Influenza A ko05165 Human papillomavirus infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05206 MicroRNAs in cancer ko05211 Renal cell carcinoma ko05213 Endometrial cancer ko05214 Glioma ko05215 Prostate cancer ko05216 Thyroid cancer ko05218 Melanoma ko05219 Bladder cancer ko05220 Chronic myeloid leukemia ko05221 Acute myeloid leukemia ko05223 Non-small cell lung cancer ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer ko05230 Central carbon metabolism in cancer ko05231 Choline metabolism in cancer Mitogen-activated protein kinase kinase (MAP2K) T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- A0A0R4J1L4 AP-1 complex subunit mu-2 Ap1m2 1780.4 1610.7 1667.5 1785.5 1730.4 1793.4 0.95278096924265 0.194415576716859 -0.0697834976524317 Nonsignificant None -- -- AP-1 complex subunit mu -- ko04142 Lysosome Adaptor complexes medium subunit family U Intracellular trafficking, secretion, and vesicular transport ; IPR022775 [AP complex, mu/sigma subunit] ; IPR028565[Mu homology domain] -- -- Q3V100 Mannose-6-phosphate isomerase Mpi 1691.7 1627 1557.3 1968.9 1966.4 1903.3 0.835131709656424 0.00193601419381711 -0.259924350134834 Nonsignificant None 3 Molecular Function:mannose-6-phosphate isomerase activity (GO:0004476),Biological Process:carbohydrate metabolic process (GO:0005975),Molecular Function:zinc ion binding (GO:0008270) mannose-6-phosphate isomerase 5.3.1.8 ko00051 Fructose and mannose metabolism ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways Mannose-6-phosphate isomerase G Carbohydrate transport and metabolism ; IPR001250 [Mannose-6-phosphate isomerase, type I] -- -- P21447 ATP-dependent translocase ABCB1 Abcb1a 637.5 597.2 702.8 996.3 933.3 982.3 0.665373124077063 0.000855084386883494 -0.587764501200111 Significant down 5 Molecular Function:ATP binding (GO:0005524),Biological Process:transport (GO:0006810),Cellular Component:integral component of membrane (GO:0016021),Molecular Function:ATPase activity (GO:0016887),Biological Process:transmembrane transport (GO:0055085) ATP-binding cassette, subfamily B (MDR/TAP), member 1 3.6.3.44 ko02010 ABC transporters ko04976 Bile secretion ko05206 MicroRNAs in cancer ko05226 Gastric cancer Multidrug/pheromone exporter, ABC superfamily Q Secondary metabolites biosynthesis, transport and catabolism ; IPR003439 [ABC transporter-like] ; IPR011527[ABC transporter type 1, transmembrane domain] -- -- A2RRK3 Non-specific serine/threonine protein kinase Slk 3069.1 3127.6 2925.3 2835.7 2811.2 2826.7 1.07652001510574 0.0674265961535183 0.106375142937899 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) STE20-like kinase 2.7.11.1 ko04114 Oocyte meiosis Ste20-like serine/threonine protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR022165[Polo kinase kinase] -- -- P29387 Guanine nucleotide-binding protein subunit beta-4 Gnb4 240.9 238.7 296.2 342.9 303.2 335.7 0.790181299653697 0.0375922620803891 -0.339744390834638 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) guanine nucleotide-binding protein subunit beta-4 -- ko04014 Ras signaling pathway ko04062 Chemokine signaling pathway ko04151 PI3K-Akt signaling pathway ko04371 Apelin signaling pathway ko04713 Circadian entrainment ko04723 Retrograde endocannabinoid signaling ko04724 Glutamatergic synapse ko04725 Cholinergic synapse ko04726 Serotonergic synapse ko04727 GABAergic synapse ko04728 Dopaminergic synapse ko04926 Relaxin signaling pathway ko05032 Morphine addiction ko05034 Alcoholism ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05200 Pathways in cancer G-protein beta subunit R General function prediction only ; IPR001680 [WD40 repeat] -- -- Q9JKY5 Huntingtin-interacting protein 1-related protein Hip1r 1517.9 1524.8 1466.9 1405.6 1510.3 1567.2 1.00591108830943 0.870213547499299 0.00850279209786576 Nonsignificant None 2 Molecular Function:actin binding (GO:0003779),Molecular Function:phospholipid binding (GO:0005543) huntingtin-interacting protein 1-related protein -- -- Actin-binding protein SLA2/Huntingtin-interacting protein Hip1 Z Cytoskeleton ; IPR002558 [I/LWEQ domain] ; IPR011417[AP180 N-terminal homology (ANTH) domain] ; IPR032422[Huntingtin-interacting protein 1, clathrin-binding domain] -- -- Q7TS98 Anti-colorectal carcinoma light chain 352.5 391.9 367.9 260.3 256.1 282.6 1.39211514392991 0.00177662719060308 0.477278543590784 Nonsignificant None -- -- immunoglobulin lambda-like polypeptide 1 -- -- -- -- -- IPR003597 [Immunoglobulin C1-set] ; IPR013106[Immunoglobulin V-set domain] -- -- Q8BNA5 SH3 domain-containing protein Cttn 6183.8 6267.8 6274.8 4679.7 5357.6 4516.2 1.286728278421 0.0312460335694031 0.363707428257435 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) cortactin -- ko04530 Tight junction ko05100 Bacterial invasion of epithelial cells ko05205 Proteoglycans in cancer -- -- -- IPR001452 [SH3 domain] ; IPR003134[Hs1/Cortactin] -- -- A0A1L7NR37 Arg/Abl-binding protein 2 Sorbs2 2097 1964.4 1977.4 2496.3 2379.7 2389 0.831218169304887 0.0019240245868886 -0.266700904938348 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Sorbin and SH3 domain-containing protein T Signal transduction mechanisms ; IPR001452 [SH3 domain] ; IPR003127[SoHo domain] -- -- G3UYU4 Flotillin Flot1 1569.3 1543 1462.8 1431.4 1451.2 1547.5 1.03273063813458 0.371647723236586 0.0464640124776714 Nonsignificant None -- -- flotillin -- ko04910 Insulin signaling pathway Flotillins UZ Intracellular trafficking, secretion, and vesicular transport ; Cytoskeleton ; IPR001107 [Band 7 domain] ; IPR031905[Flotillin, C-terminal domain] -- -- Q3TUQ7 Acetyl-CoA carboxylase kinase Prkaa1 2367.3 2505.9 2375.2 2263.2 2233.4 2099.2 1.09894175081112 0.0322790870768844 0.136114918550073 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) 5'-AMP-activated protein kinase, catalytic alpha subunit 2.7.11.11 ko04068 FoxO signaling pathway ko04140 Autophagy - animal ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04152 AMPK signaling pathway ko04211 Longevity regulating pathway ko04213 Longevity regulating pathway - multiple species ko04371 Apelin signaling pathway ko04530 Tight junction ko04710 Circadian rhythm ko04910 Insulin signaling pathway ko04920 Adipocytokine signaling pathway ko04921 Oxytocin signaling pathway ko04922 Glucagon signaling pathway ko04931 Insulin resistance ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05410 Hypertrophic cardiomyopathy (HCM) ko05418 Fluid shear stress and atherosclerosis Serine/threonine protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR032270[AMPK, C-terminal adenylate sensor domain] -- -- Q9DBG7 Signal recognition particle receptor subunit alpha Srpra 1285.2 1189.3 1213.9 1146.1 1130.3 1194.7 1.06260263317104 0.104971354331333 0.0876021929829997 Nonsignificant None 6 Molecular Function:GTPase activity (GO:0003924),Molecular Function:signal recognition particle binding (GO:0005047),Molecular Function:GTP binding (GO:0005525),Cellular Component:signal recognition particle receptor complex (GO:0005785),Biological Process:SRP-dependent cotranslational protein targeting to membrane (GO:0006614),Biological Process:intracellular protein transport (GO:0006886) signal recognition particle receptor subunit alpha -- ko03060 Protein export Signal recognition particle receptor, alpha subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR000897 [Signal recognition particle, SRP54 subunit, GTPase domain] ; IPR007222[Signal recognition particle receptor, alpha subunit, N-terminal] ; IPR013822[Signal recognition particle, SRP54 subunit, helical bundle] -- -- E9Q2X6 Structural maintenance of chromosomes protein Smc4 3854.9 3937.4 3773.2 3116.6 3194.5 2983.5 1.24432466163148 0.000622606076921068 0.315362953809316 Nonsignificant None 4 Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Cellular Component:chromosome (GO:0005694),Biological Process:chromosome organization (GO:0051276) structural maintenance of chromosome 4 -- Structural maintenance of chromosome protein 4 (chromosome condensation complex Condensin, subunit C) BD Chromatin structure and dynamics ; Cell cycle control, cell division, chromosome partitioning ; IPR003395 [RecF/RecN/SMC, N-terminal] ; IPR010935[SMCs flexible hinge] -- -- Q9CQF9 Prenylcysteine oxidase 1 Pcyox1 1838.2 1817.4 1892.5 1952.6 1916.6 2074.3 0.933473542525448 0.0667097628111194 -0.0993189622144103 Nonsignificant None 2 Biological Process:prenylcysteine catabolic process (GO:0030328),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00900 Terpenoid backbone biosynthesis -- -- -- IPR010795 [Prenylcysteine lyase] -- -- P57722 Poly(rC)-binding protein 3 Pcbp3 345.3 317.4 333.8 334.4 348.1 356.1 0.95946466397073 0.243955363090217 -0.0596984203613743 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) poly(rC)-binding protein 3/4 -- -- PolyC-binding proteins alphaCP-1 and related KH domain proteins AR RNA processing and modification ; General function prediction only ; IPR004088 [K Homology domain, type 1] -- -- A3KMP2 Tetratricopeptide repeat protein 38 Ttc38 1871.2 1852.9 2409.6 3034 3302.3 3658.1 0.61371367966061 0.00744386042672435 -0.704362353421767 Significant down -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; -- -- -- Q61210 Rho guanine nucleotide exchange factor 1 Arhgef1 2144.1 2240.5 2246.7 2179.2 2198.1 2200.8 1.00808744166249 0.628566599316096 0.0116207838591299 Nonsignificant None 3 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Cellular Component:cytoplasm (GO:0005737),Biological Process:regulation of Rho protein signal transduction (GO:0035023) Rho guanine nucleotide exchange factor 1 -- ko04270 Vascular smooth muscle contraction ko04611 Platelet activation ko04810 Regulation of actin cytoskeleton ko05200 Pathways in cancer ko05205 Proteoglycans in cancer Predicted guanine nucleotide exchange factor T Signal transduction mechanisms ; IPR000219 [Dbl homology (DH) domain] ; IPR015212[Regulator of G protein signalling-like domain] -- -- P70698 CTP synthase 1 Ctps1 3202.3 3391.1 2853 2692.9 2689.6 2507.4 1.19727753203463 0.0373712132620186 0.259757611496339 Nonsignificant None 2 Molecular Function:CTP synthase activity (GO:0003883),Biological Process:pyrimidine nucleotide biosynthetic process (GO:0006221) CTP synthase 6.3.4.2 ko00240 Pyrimidine metabolism ko01100 Metabolic pathways CTP synthase (UTP-ammonia lyase) F Nucleotide transport and metabolism ; IPR017456 [CTP synthase, N-terminal] ; IPR017926[Glutamine amidotransferase] -- -- Q91VM9 Inorganic pyrophosphatase 2, mitochondrial Ppa2 2915.9 2788.5 3469 4006.8 3846.2 3847.5 0.784017777018076 0.0174264780419288 -0.35104172814247 Nonsignificant None 4 Molecular Function:magnesium ion binding (GO:0000287),Molecular Function:inorganic diphosphatase activity (GO:0004427),Cellular Component:cytoplasm (GO:0005737),Biological Process:phosphate-containing compound metabolic process (GO:0006796) inorganic pyrophosphatase 3.6.1.1 ko00190 Oxidative phosphorylation Inorganic pyrophosphatase/Nucleosome remodeling factor, subunit NURF38 C Energy production and conversion ; IPR008162 [Inorganic pyrophosphatase] -- -- Q9CQM8 60S ribosomal protein L21 Rpl21 4692.4 4463.2 4222.4 3577 3656.7 3772.5 1.21549672003053 0.00578712118858415 0.281546000316806 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L21e -- ko03010 Ribosome 60S ribosomal protein L21 J Translation, ribosomal structure and biogenesis ; IPR001147 [Ribosomal protein L21e] -- -- Q6DFZ1 Golgi-specific brefeldin A-resistance factor 1 Gbf1 1893.1 1914.3 2034 1925.2 1967.7 1883.7 1.01121767129453 0.688697198736727 0.0160935803228948 Nonsignificant None 2 Molecular Function:ARF guanyl-nucleotide exchange factor activity (GO:0005086),Biological Process:regulation of ARF protein signal transduction (GO:0032012) golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 -- ko04144 Endocytosis Pattern-formation protein/guanine nucleotide exchange factor U Intracellular trafficking, secretion, and vesicular transport ; IPR000904 [Sec7 domain] ; IPR032691[Guanine nucleotide exchange factor, N-terminal] -- -- Q91Z53 Glyoxylate reductase/hydroxypyruvate reductase Grhpr 1315.3 1264.8 1498.8 1436.1 1450.7 1455.3 0.939384168950508 0.342360698226209 -0.0902128142244323 Nonsignificant None 3 Biological Process:metabolic process (GO:0008152),Molecular Function:NAD binding (GO:0051287),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00260 Glycine, serine and threonine metabolism ko00620 Pyruvate metabolism ko00630 Glyoxylate and dicarboxylate metabolism ko01100 Metabolic pathways Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily) C Energy production and conversion ; IPR006139 [D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain] ; IPR006140[D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain] -- -- A0A1L1SV73 Ubiquitin carboxyl-terminal hydrolase 47 Usp47 3149.4 3063.9 3249.2 3137 3140.2 3202.4 0.998196126418836 0.925958785413617 -0.00260478953240788 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Biological Process:protein deubiquitination (GO:0016579),Molecular Function:thiol-dependent ubiquitinyl hydrolase activity (GO:0036459) ubiquitin carboxyl-terminal hydrolase 47 3.4.19.12 -- Putative ubiquitin-specific protease O Posttranslational modification, protein turnover, chaperones ; IPR000626 [Ubiquitin domain] ; IPR001394[Peptidase C19, ubiquitin carboxyl-terminal hydrolase] -- -- P49817 Caveolin-1 Cav1 4791.7 4821.1 5147 6735.7 6520.1 6443.6 0.74925124623085 0.000329844448576772 -0.416478516509445 Nonsignificant None 1 Biological Process:caveola assembly (GO:0070836) caveolin 1 -- ko04144 Endocytosis ko04510 Focal adhesion ko05100 Bacterial invasion of epithelial cells ko05205 Proteoglycans in cancer ko05416 Viral myocarditis ko05418 Fluid shear stress and atherosclerosis -- -- -- IPR001612 [Caveolin] -- -- Q9Z0L8 Gamma-glutamyl hydrolase Ggh 2241.1 2009 2319.2 5930.6 5771.4 5849.3 0.374291363032938 0.00000386911323588578 -1.41776633720069 Significant down 2 Biological Process:glutamine metabolic process (GO:0006541),Molecular Function:hydrolase activity (GO:0016787) gamma-glutamyl hydrolase 3.4.19.9 ko00790 Folate biosynthesis ko01523 Antifolate resistance Gamma-glutamyl hydrolase H Coenzyme transport and metabolism ; IPR011697 [Peptidase C26] -- -- Q99KH8 Serine/threonine-protein kinase 24 Stk24 1369.2 1394.2 1397.1 1397.8 1396.6 1426 0.985807032508767 0.201193876807695 -0.0206228220042746 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) serine/threonine-protein kinase 24/25/MST4 2.7.11.1 -- Serine/threonine protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q9DC61 Mitochondrial-processing peptidase subunit alpha Pmpca 4482.6 4240.9 4336.7 3873.7 3896.1 3825.3 1.12635509827427 0.00263788507301565 0.171661727734665 Nonsignificant None -- -- mitochondrial-processing peptidase subunit alpha 3.4.24.64 -- Mitochondrial processing peptidase, alpha subunit O Posttranslational modification, protein turnover, chaperones ; IPR007863 [Peptidase M16, C-terminal] ; IPR011765[Peptidase M16, N-terminal] -- -- Q3TIF8 40S ribosomal protein S24 Rps24 4568 4327.1 4324.4 4075.8 3983.3 4148.5 1.08289098594318 0.0228731381880074 0.114888014917396 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S24e -- ko03010 Ribosome 40S ribosomal protein S24 J Translation, ribosomal structure and biogenesis ; IPR001976 [Ribosomal protein S24e] -- -- P32233 Developmentally-regulated GTP-binding protein 1 Drg1 2577.8 2600.4 2676.4 2601.9 2628.7 2567.7 1.00721952220356 0.616897223930882 0.010378151149423 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) -- -- -- GTP-binding protein DRG1 (ODN superfamily) T Signal transduction mechanisms ; IPR004095 [TGS] ; IPR006073[GTP binding domain] ; IPR031662[GTP binding protein, second domain] -- -- Q8CGY8 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit Ogt 2384.9 2284.5 2333.8 2109 2138.1 2163.7 1.09240656392338 0.00392627636465446 0.127509887937237 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) protein O-GlcNAc transferase 2.4.1.255 ko00514 Other types of O-glycan biosynthesis ko04931 Insulin resistance O-linked N-acetylglucosamine transferase OGT GOT Carbohydrate transport and metabolism ; Posttranslational modification, protein turnover, chaperones ; Signal transduction mechanisms ; IPR001440 [Tetratricopeptide repeat 1] ; IPR011990[Tetratricopeptide-like helical domain] ; IPR019734[Tetratricopeptide repeat] ; IPR029489[O-GlcNAc transferase, C-terminal] -- -- Q8K2Q9 Shootin-1 Shtn1 2827.7 2812 2874.2 2705.3 2788.4 2733.4 1.0348604003841 0.035837742020792 0.0494361655438524 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- P13439 Uridine 5-monophosphate synthase Umps 2147.9 1841.3 1985.4 1965.7 1836.2 2029.8 1.02450400397826 0.674419781406214 0.0349256227174239 Nonsignificant None 3 Molecular Function:orotidine-5'-phosphate decarboxylase activity (GO:0004590),Biological Process:'de novo' pyrimidine nucleobase biosynthetic process (GO:0006207),Biological Process:nucleoside metabolic process (GO:0009116) -- -- ko00240 Pyrimidine metabolism ko00983 Drug metabolism - other enzymes ko01100 Metabolic pathways Uridine 5'- monophosphate synthase/orotate phosphoribosyltransferase F Nucleotide transport and metabolism ; IPR000836 [Phosphoribosyltransferase domain] ; IPR001754[Orotidine 5'-phosphate decarboxylase domain] -- -- Q3TEX8 Ubiquitin carboxyl-terminal hydrolase Usp4 2499.1 2441 1995.5 1992.1 1990 2089.4 1.14232067858025 0.150831743843208 0.191967708891426 Nonsignificant None 3 Molecular Function:thiol-dependent ubiquitin-specific protease activity (GO:0004843),Biological Process:protein deubiquitination (GO:0016579),Molecular Function:thiol-dependent ubiquitinyl hydrolase activity (GO:0036459) ubiquitin carboxyl-terminal hydrolase 4/11 3.4.19.12 -- Ubiquitin C-terminal hydrolase O Posttranslational modification, protein turnover, chaperones ; IPR001394 [Peptidase C19, ubiquitin carboxyl-terminal hydrolase] ; IPR006615[Peptidase C19, ubiquitin-specific peptidase, DUSP domain] ; IPR028135[Ubiquitin-like domain, USP-type] -- -- E9QAS9 Synaptic functional regulator FMR1 Fmr1 97.8 68.6 58.8 76.9 72.7 83.2 0.967353951890034 0.844447345199184 -0.0478842308280544 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) fragile X mental retardation protein -- ko03013 RNA transport -- -- -- IPR004088 [K Homology domain, type 1] ; IPR008395[Agenet-like domain] ; IPR022034[Fragile X-related 1 protein, C-terminal core] ; IPR032196[Fragile X-related mental retardation protein, C-terminal region 2] -- -- Q5BLJ7 40S ribosomal protein S13 Rps13 9354.9 9426.8 7132.6 6236.9 6458.9 6147.8 1.37523084760874 0.0865684593894776 0.459673811180078 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S13e -- ko03010 Ribosome 40S ribosomal protein S13 J Translation, ribosomal structure and biogenesis ; IPR000589 [Ribosomal protein S15] ; IPR012606[Ribosomal protein S13/S15, N-terminal] -- -- Q6DFW4 Nucleolar protein 58 Nop58 2292.1 2360.8 2349.7 2331.2 2381.4 2389.2 0.986031710270636 0.302948281979828 -0.0202940512105819 Nonsignificant None -- -- nucleolar protein 58 -- ko03008 Ribosome biogenesis in eukaryotes Ribosome biogenesis protein - Nop58p/Nop5p AJ RNA processing and modification ; Translation, ribosomal structure and biogenesis ; IPR002687 [Nop domain] ; IPR012974[NOP5, N-terminal] -- -- Q8R038 Melanocyte proliferating gene 1 Myg1 2384.4 2271.5 2252.2 2138.3 2219.1 2333 1.03253916058831 0.35797323830881 0.0461964990444019 Nonsignificant None -- -- -- -- -- Predicted metal-binding protein R General function prediction only ; IPR003226 [Metal-dependent protein hydrolase] -- -- G3UXL2 Ribose-phosphate diphosphokinase Prps1l3 1385.1 1353.3 1290.5 1272.7 1207.6 1210.3 1.09166531187341 0.0322071800575895 0.126530615497119 Nonsignificant None 3 Molecular Function:magnesium ion binding (GO:0000287),Molecular Function:ribose phosphate diphosphokinase activity (GO:0004749),Biological Process:nucleotide biosynthetic process (GO:0009165) ribose-phosphate pyrophosphokinase 2.7.6.1 ko00030 Pentose phosphate pathway ko00230 Purine metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids Ribose-phosphate pyrophosphokinase FE Nucleotide transport and metabolism ; Amino acid transport and metabolism ; IPR005946 [Ribose-phosphate diphosphokinase] ; IPR029099[Ribose-phosphate pyrophosphokinase, N-terminal domain] -- -- Q6PDL0 Cytoplasmic dynein 1 light intermediate chain 2 Dync1li2 2461.9 2511.3 2470.3 2580.1 2649.8 2678 0.94127391595746 0.00922828983647974 -0.0873134785345208 Nonsignificant None -- -- dynein light intermediate chain 1, cytosolic -- ko04145 Phagosome ko04962 Vasopressin-regulated water reabsorption ko05132 Salmonella infection Dynein light intermediate chain N Cell motility ; IPR022780 [Dynein family light intermediate chain] -- -- O08784 Treacle protein Tcof1 2400.9 2409.1 2074.4 1940.4 2112.7 2012.1 1.13506562025984 0.087035661214664 0.182775704817406 Nonsignificant None -- -- Treacher Collins syndrome protein -- ko03008 Ribosome biogenesis in eukaryotes -- -- -- IPR003993 [Treacher Collins syndrome, treacle] -- -- Q8C1W9 Uncharacterized protein Nap1l4 1717 1683 1800.7 1699.5 1711.4 1621 1.03354597666885 0.27954893811938 0.0476025676088336 Nonsignificant None 2 Cellular Component:nucleus (GO:0005634),Biological Process:nucleosome assembly (GO:0006334) nucleosome assembly protein 1-like 4 -- -- Nucleosome assembly protein NAP-1 BD Chromatin structure and dynamics ; Cell cycle control, cell division, chromosome partitioning ; IPR002164 [Nucleosome assembly protein (NAP)] -- -- Q9DC23 DnaJ homolog subfamily C member 10 Dnajc10 1993.5 2201.8 2032.1 2103.2 1980.2 1985.2 1.02616748508717 0.522168581989015 0.037266218454613 Nonsignificant None 1 Biological Process:cell redox homeostasis (GO:0045454) DnaJ homolog subfamily C member 10 -- ko04141 Protein processing in endoplasmic reticulum Thioredoxin/protein disulfide isomerase O Posttranslational modification, protein turnover, chaperones ; IPR001623 [DnaJ domain] ; IPR013766[Thioredoxin domain] -- -- Q9R069 Basal cell adhesion molecule Bcam 1671.9 1700.8 1928.5 2078.2 2104.6 2236.1 0.825873592048482 0.0170468490641248 -0.276007114793097 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) Lutheran blood group glycoprotein -- -- -- -- -- IPR007110 [Immunoglobulin-like domain] ; IPR013162[CD80-like, immunoglobulin C2-set] -- -- Q99P88 Nuclear pore complex protein Nup155 Nup155 1514.7 1558.1 1461.7 1526.5 1538.8 1520.5 0.988813293209473 0.579434666908198 -0.0162299565009888 Nonsignificant None -- -- nuclear pore complex protein Nup155 -- ko03013 RNA transport Nuclear pore complex, Nup155 component (D Nup154, sc Nup157/Nup170) YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; IPR007187 [Nucleoporin, Nup133/Nup155-like, C-terminal] ; IPR014908[Nucleoporin, Nup133/Nup155-like, N-terminal] -- -- Z4YJI3 Epithelial splicing regulatory protein 1 Esrp1 2188 2084.8 2255.5 2100.4 2213.4 2152.1 1.00965062868278 0.743938869699839 0.0138561608354521 Nonsignificant None -- -- epithelial splicing regulatory protein 1/2 -- -- RNA-binding protein Fusilli, contains RRM domain AR RNA processing and modification ; General function prediction only ; -- -- -- Q5SWU9 Acetyl-CoA carboxylase 1 Acaca 1836 1787.7 1905.4 1962.2 2038.9 2021.1 0.918119624057653 0.0163761063115112 -0.123245956726214 Nonsignificant None 3 Molecular Function:acetyl-CoA carboxylase activity (GO:0003989),Molecular Function:ATP binding (GO:0005524),Biological Process:fatty acid biosynthetic process (GO:0006633) -- -- ko00061 Fatty acid biosynthesis ko00620 Pyruvate metabolism ko00640 Propanoate metabolism ko01100 Metabolic pathways ko01212 Fatty acid metabolism ko04152 AMPK signaling pathway ko04910 Insulin signaling pathway ko04922 Glucagon signaling pathway Acetyl-CoA carboxylase I Lipid transport and metabolism ; IPR000022 [Carboxyl transferase] ; IPR000089[Biotin/lipoyl attachment] ; IPR005479[Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain] ; IPR005481[Biotin carboxylase-like, N-terminal domain] ; IPR005482[Biotin carboxylase, C-terminal] ; IPR013537[Acetyl-CoA carboxylase, central domain] -- -- Q8C2Q3 RNA-binding protein 14 Rbm14 3053.8 3101.1 3095.9 2846.1 2927.7 2739.7 1.08660362952957 0.0121223075700407 0.119825771094419 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) RNA-binding protein 14 -- -- -- -- -- IPR000504 [RNA recognition motif domain] -- -- Q3U0V2 Tumor necrosis factor receptor type 1-associated DEATH domain protein Tradd 2366 2284.8 2285.1 2565.9 2751.4 2465.5 0.891183121755666 0.0326436907566118 -0.166206185357963 Nonsignificant None 4 Molecular Function:signal transducer activity (GO:0004871),Molecular Function:protein binding (GO:0005515),Biological Process:signal transduction (GO:0007165),Biological Process:positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123) tumor necrosis factor receptor type 1-associated DEATH domain protein -- ko04010 MAPK signaling pathway ko04064 NF-kappa B signaling pathway ko04071 Sphingolipid signaling pathway ko04210 Apoptosis ko04217 Necroptosis ko04622 RIG-I-like receptor signaling pathway ko04657 IL-17 signaling pathway ko04668 TNF signaling pathway ko04920 Adipocytokine signaling pathway ko05152 Tuberculosis ko05160 Hepatitis C ko05165 Human papillomavirus infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis -- -- -- IPR000488 [Death domain] ; IPR009095[TRADD, N-terminal] -- -- A0A1L1STC6 Nesprin-1 Syne1 1158.7 1210.6 1289.7 1390.7 1392 1363.2 0.882558672423358 0.0144072885809438 -0.180235903075204 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:integral component of membrane (GO:0016021) nesprin-1 -- -- Dystonin, GAS (Growth-arrest-specific protein), and related proteins Z Cytoskeleton ; IPR001715 [Calponin homology domain] ; IPR002017[Spectrin repeat] ; IPR012315[KASH domain] -- -- Q3UMT1 Protein phosphatase 1 regulatory subunit 12C Ppp1r12c 1345.2 1393.7 1583.7 1770.1 1550.2 1590.6 0.880205257692073 0.119548706991742 -0.18408810554115 Nonsignificant None 1 Molecular Function:protein kinase binding (GO:0019901) protein phosphatase 1 regulatory subunit 12C -- ko04270 Vascular smooth muscle contraction ko04510 Focal adhesion ko04810 Regulation of actin cytoskeleton ko04921 Oxytocin signaling pathway ko05205 Proteoglycans in cancer Myosin phosphatase, regulatory subunit OT Posttranslational modification, protein turnover, chaperones ; Signal transduction mechanisms ; IPR020683 [Ankyrin repeat-containing domain] ; IPR031775[cGMP-dependent protein kinase, interacting domain] -- -- A0MNP4 CDW13/WDR61 Wdr61 2336.5 2370.1 2356.3 2159 2186.1 2060.8 1.10256170093195 0.00507797629996198 0.140859393322732 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) WD repeat-containing protein 61 -- ko03018 RNA degradation FOG: WD40 repeat R General function prediction only ; IPR001680 [WD40 repeat] -- -- Q3ULW8 Protein mono-ADP-ribosyltransferase PARP3 Parp3 1789.3 1708.9 1688.1 2014.3 2006.9 2036.7 0.85612175836511 0.000828777628616078 -0.224112102352449 Nonsignificant None 2 Molecular Function:NAD+ ADP-ribosyltransferase activity (GO:0003950),Biological Process:protein ADP-ribosylation (GO:0006471) poly [ADP-ribose] polymerase 2.4.2.30 ko03410 Base excision repair ko04210 Apoptosis ko04217 Necroptosis NAD+ ADP-ribosyltransferase Parp, required for poly-ADP ribosylation of nuclear proteins KLO Transcription ; Replication, recombination and repair ; Posttranslational modification, protein turnover, chaperones ; IPR004102 [Poly(ADP-ribose) polymerase, regulatory domain] ; IPR008893[WGR domain] ; IPR012317[Poly(ADP-ribose) polymerase, catalytic domain] -- -- Q3TN39 Aamy domain-containing protein Slc3a2 3342.1 3461.1 3202 2955.2 3083 2977.3 1.10977760523543 0.0175679649222035 0.150270595521239 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:carbohydrate metabolic process (GO:0005975) solute carrier family 3, member 2 -- ko04150 mTOR signaling pathway ko04216 Ferroptosis ko04974 Protein digestion and absorption Alpha-amylase G Carbohydrate transport and metabolism ; IPR006047 [Glycosyl hydrolase, family 13, catalytic domain] ; IPR031984[Solute carrier family 3 member 2, N-terminal domain] -- -- Q7TNG5 Echinoderm microtubule-associated protein-like 2 Eml2 3513.1 3621.2 3563 3847.5 3593 3943.6 0.939670241828515 0.103979645256182 -0.0897735337828918 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) echinoderm microtubule-associated protein-like 1/2 -- -- Uncharacterized conserved protein, contains HELP and WD40 domains S Function unknown ; IPR001680 [WD40 repeat] ; IPR005108[HELP] -- -- B2RX12 ATP-binding cassette sub-family C member 3 Abcc3 1891.4 1682.4 1783.7 2147 2302.1 2140 0.813085246847066 0.006907071923813 -0.298521477204308 Nonsignificant None 5 Molecular Function:ATP binding (GO:0005524),Biological Process:transport (GO:0006810),Cellular Component:integral component of membrane (GO:0016021),Molecular Function:ATPase activity (GO:0016887),Biological Process:transmembrane transport (GO:0055085) ATP-binding cassette, subfamily C (CFTR/MRP), member 3 -- ko01523 Antifolate resistance ko02010 ABC transporters ko04976 Bile secretion Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Q Secondary metabolites biosynthesis, transport and catabolism ; IPR003439 [ABC transporter-like] ; IPR011527[ABC transporter type 1, transmembrane domain] -- -- P11352 Glutathione peroxidase 1 Gpx1 2927.6 2954.6 2839 3459.8 3505.6 3516.5 0.832024728341236 0.000113589895214538 -0.265301688005231 Nonsignificant None 3 Molecular Function:glutathione peroxidase activity (GO:0004602),Biological Process:response to oxidative stress (GO:0006979),Biological Process:oxidation-reduction process (GO:0055114) glutathione peroxidase 1.11.1.9 ko00480 Glutathione metabolism ko00590 Arachidonic acid metabolism ko04918 Thyroid hormone synthesis Glutathione peroxidase O Posttranslational modification, protein turnover, chaperones ; IPR000889 [Glutathione peroxidase] -- -- Q9JIW9 Ras-related protein Ral-B Ralb 1619.7 1554.1 1728.5 1901.2 1978.8 1830.9 0.858411108581835 0.0153690783165756 -0.220259348951098 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Ral-B -- ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04072 Phospholipase D signaling pathway ko05200 Pathways in cancer ko05210 Colorectal cancer ko05212 Pancreatic cancer Ras-related GTPase R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- Q80VD1 Protein FAM98B Fam98b 1084.8 1205.8 1295.2 1412.3 1373.8 1374.1 0.861929714917552 0.0371571925169679 -0.214357863709944 Nonsignificant None -- -- protein FAM98B -- -- Uncharacterized conserved glycine-rich protein S Function unknown ; IPR018797 [Uncharacterised protein family FAM98] -- -- P19467 Mucin-13 Muc13 3077.8 2746.7 3180.5 2696.1 3131.7 2856.5 1.03692871043147 0.589513650259478 0.0523167112751691 Nonsignificant None -- -- mucin-13 -- -- -- -- -- -- -- -- Q3TJD4 ATP synthase subunit b Atp5pb 5149.2 5077.3 6569.4 6798 6323.4 6820.5 0.842241712173865 0.109992588187299 -0.24769376787692 Nonsignificant None 2 Molecular Function:hydrogen ion transmembrane transporter activity (GO:0015078),Biological Process:ATP synthesis coupled proton transport (GO:0015986) F-type H+-transporting ATPase subunit b -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Mitochondrial F1F0-ATP synthase, subunit b/ATP4 C Energy production and conversion ; IPR008688 [ATP synthase, F0 complex, subunit B/MI25] -- -- A0A2I3BRM6 Heterogeneous nuclear ribonucleoproteins C1/C2 (Fragment) Hnrnpc 405.1 391.9 341.5 419.3 442.9 393.2 0.90688226859965 0.181427454982472 -0.141012822559096 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) heterogeneous nuclear ribonucleoprotein C1/C2 -- ko03040 Spliceosome FOG: RRM domain R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- Q4FJL0 Rab10 Rab10 1374.1 1290.5 1582.3 1778.2 1778.2 1749.6 0.800395778364116 0.0538340751443325 -0.321214537025538 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-10 -- ko04144 Endocytosis ko04152 AMPK signaling pathway GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- Q7TQI3 Ubiquitin thioesterase OTUB1 Otub1 2109 2151.2 2350 2229.2 2337.9 2243.3 0.97060378245037 0.460235680316137 -0.0430456125806784 Nonsignificant None -- -- ubiquitin thioesterase protein OTUB1 3.4.19.12 -- Uncharacterized conserved protein S Function unknown ; IPR019400 [Peptidase C65, otubain] -- -- P62889 60S ribosomal protein L30 Rpl30 4757 4843.5 3849.9 3161.4 3191.2 3464.9 1.37004329004329 0.0218451626263731 0.454221479568329 Nonsignificant None -- -- large subunit ribosomal protein L30e -- ko03010 Ribosome 60S ribosomal protein L30 J Translation, ribosomal structure and biogenesis ; IPR004038 [Ribosomal protein L7Ae/L30e/S12e/Gadd45] -- -- Q80YG4 SEC63 Sec63 1868 1860.8 2113.1 1865.1 1942.5 1784.1 1.0447448897473 0.428225475482713 0.0631507018962609 Nonsignificant None -- -- translocation protein SEC63 -- ko03060 Protein export ko04141 Protein processing in endoplasmic reticulum Molecular chaperone SEC63, endoplasmic reticulum translocon component UO Intracellular trafficking, secretion, and vesicular transport ; Posttranslational modification, protein turnover, chaperones ; IPR001623 [DnaJ domain] ; IPR004179[Sec63 domain] -- -- Q9Z1D1 Eukaryotic translation initiation factor 3 subunit G Eif3g 3312.8 3323.3 3184.9 2545.3 2488.8 2504.4 1.30277906745374 0.000089346543291674 0.381592444371093 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) translation initiation factor 3 subunit G -- ko03013 RNA transport Translation initiation factor 3, subunit g (eIF-3g) J Translation, ribosomal structure and biogenesis ; IPR000504 [RNA recognition motif domain] ; IPR024675[Eukaryotic translation initiation factor 3 subunit G, N-terminal] -- -- Q8BLV4 Uncharacterized protein (Fragment) Lrrfip1 221.9 244.2 309.1 302.6 293.7 272.6 0.892162504315802 0.321429669820662 -0.164621578892415 Nonsignificant None -- -- -- -- -- Double stranded RNA binding protein R General function prediction only ; IPR019139 [Leucine-rich repeat flightless-interacting protein 1/2] -- -- Q9D554 Splicing factor 3A subunit 3 Sf3a3 2707 2741.4 2524.2 2330.6 2378.4 2316.6 1.13479275791391 0.0107177534727944 0.182428848679598 Nonsignificant None -- -- splicing factor 3A subunit 3 -- ko03040 Spliceosome Splicing factor 3a, subunit 3 A RNA processing and modification ; IPR021966 [Splicing factor SF3a60 binding domain] ; IPR024598[Domain of unknown function DUF3449] ; IPR031774[SF3A3 domain] -- -- A2AJ72 Far upstream element (FUSE)-binding protein 3 Fubp3 2041.5 1894.9 1864.2 1819.7 1802.7 1795.8 1.07057694437267 0.142949193886027 0.0983884886478777 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) far upstream element-binding protein -- -- K-homology type RNA binding proteins A RNA processing and modification ; IPR004088 [K Homology domain, type 1] -- -- Q4V9X9 Rpl23a protein (Fragment) Rpl23a 8164.7 8661.9 7678 6553.6 6728.6 6800.9 1.22016023422679 0.00736529109982367 0.28707061823478 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L23Ae -- ko03010 Ribosome 60s ribosomal protein L23 J Translation, ribosomal structure and biogenesis ; IPR005633 [Ribosomal protein L23/L25, N-terminal] ; IPR013025[Ribosomal protein L25/L23] -- -- E9QKZ2 Importin-9 Ipo9 2803.3 2795.3 2713.5 2374.8 2443.2 2511.3 1.13409193238099 0.00255232428835544 0.181537593555565 Nonsignificant None 2 Biological Process:intracellular protein transport (GO:0006886),Molecular Function:Ran GTPase binding (GO:0008536) importin-9 -- -- Predicted importin 9 UY Intracellular trafficking, secretion, and vesicular transport ; Nuclear structure ; IPR001494 [Importin-beta, N-terminal domain] -- -- Q9JII5 DAZ-associated protein 1 Dazap1 2249.3 2381.7 2370 2246.1 2215 2415.9 1.01803111822015 0.612824571200696 0.0257816610361526 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) RNA-binding protein Musashi -- ko03015 mRNA surveillance pathway RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- Q8C522 Endonuclease domain-containing 1 protein Endod1 1933.2 1733.7 1799.4 2002.1 1855.3 2082.2 0.920314499292882 0.149755217729722 -0.119801136940183 Nonsignificant None -- -- endonuclease domain-containing 1 protein -- -- -- -- -- -- -- -- P62317 Small nuclear ribonucleoprotein Sm D2 Snrpd2 3986.3 4016.9 4289.2 4187 4360.5 4134 0.969317509758309 0.333763391625053 -0.0449587824741859 Nonsignificant None -- -- small nuclear ribonucleoprotein D2 -- ko03040 Spliceosome Small nuclear ribonucleoprotein (snRNP) Sm core protein A RNA processing and modification ; IPR001163 [LSM domain, eukaryotic/archaea-type] -- -- P97450 ATP synthase-coupling factor 6, mitochondrial Atp5pf 4726.5 4564.1 5406.3 5586 5674.5 5943.2 0.854287159157623 0.0403218177088378 -0.227206997574955 Nonsignificant None 2 Molecular Function:hydrogen ion transmembrane transporter activity (GO:0015078),Biological Process:ATP synthesis coupled proton transport (GO:0015986) F-type H+-transporting ATPase subunit 6 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Mitochondrial F1F0-ATP synthase, subunit Cf6 (coupling factor 6) C Energy production and conversion ; IPR008387 [ATP synthase-coupling factor 6, mitochondrial] -- -- H3BJ07 Golgi phosphoprotein 3-like Golph3l 2498.8 2345.7 2369.2 2959.5 2979.4 3033.3 0.804005706515682 0.00036518839368147 -0.314722353765922 Nonsignificant None 1 Molecular Function:phosphatidylinositol-4-phosphate binding (GO:0070273) golgi phosphoprotein 3 -- -- Golgi protein U Intracellular trafficking, secretion, and vesicular transport ; IPR008628 [Golgi phosphoprotein 3-like] -- -- Q62383 Transcription elongation factor SPT6 Supt6h 1669.4 1626.5 1723 1751.2 1817.6 1796.4 0.935454409900842 0.0276464880573101 -0.0962607505743569 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:DNA binding (GO:0003677) transcription elongation factor SPT6 -- -- Transcription elongation factor SPT6 A RNA processing and modification ; IPR000980 [SH2 domain] ; IPR003029[S1 domain] ; IPR027999[Death-like domain of Spt6] ; IPR028083[Spt6 acidic, N-terminal domain] ; IPR028088[Helix-turn-helix DNA-binding domain of Spt6] ; IPR028231[Transcription elongation factor Spt6, YqgF domain] ; IPR032706[Transcription elongation factor Spt6, helix-hairpin-helix motif] -- -- Q9Z1R2 Large proline-rich protein BAG6 Bag6 1755.4 1890.7 1878.2 2053.8 1950.1 1809.8 0.950221029636892 0.308926563747816 -0.0736649590530144 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Ubiquitin-like protein, regulator of apoptosis O Posttranslational modification, protein turnover, chaperones ; IPR000626 [Ubiquitin domain] ; IPR021925[Protein of unknown function DUF3538] -- -- Q3ULJ0 Glycerol-3-phosphate dehydrogenase 1-like protein Gpd1l 2340.5 2268.3 2641.8 3075.7 3108.7 3169.8 0.775117059716491 0.00397949232021501 -0.367513889378655 Nonsignificant None 5 Molecular Function:glycerol-3-phosphate dehydrogenase [NAD+] activity (GO:0004367),Biological Process:carbohydrate metabolic process (GO:0005975),Biological Process:glycerol-3-phosphate catabolic process (GO:0046168),Molecular Function:NAD binding (GO:0051287),Biological Process:oxidation-reduction process (GO:0055114) glycerol-3-phosphate dehydrogenase (NAD+) 1.1.1.8 ko00564 Glycerophospholipid metabolism Glycerol-3-phosphate dehydrogenase/dihydroxyacetone 3-phosphate reductase C Energy production and conversion ; IPR006109 [Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal] ; IPR011128[Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal] -- -- P34022 Ran-specific GTPase-activating protein Ranbp1 4746.1 4829 3225.1 2836.6 3032.7 3002 1.44287759403921 0.126741153985371 0.528948914546322 Nonsignificant None 1 Biological Process:intracellular transport (GO:0046907) Ran-binding protein 1 -- ko05166 HTLV-I infection ko05203 Viral carcinogenesis Ran-binding protein RANBP1 and related RanBD domain proteins U Intracellular trafficking, secretion, and vesicular transport ; IPR000156 [Ran binding domain] -- -- Q60973 Histone-binding protein RBBP7 Rbbp7 1577.8 1860.6 1937 1676.7 1656.2 1605.6 1.08846815834768 0.26073543209279 0.122299204066479 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) histone-binding protein RBBP7 -- -- Nucleosome remodeling factor, subunit CAF1/NURF55/MSI1 B Chromatin structure and dynamics ; IPR001680 [WD40 repeat] ; IPR022052[Histone-binding protein RBBP4, N-terminal] -- -- Q62469 Integrin alpha-2 Itga2 2618.1 2648.7 3247 2894.2 2687.9 2763.8 1.02011766256485 0.806075341308217 0.0287355653425553 Nonsignificant None -- -- integrin alpha 2 -- ko04145 Phagosome ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04611 Platelet activation ko04640 Hematopoietic cell lineage ko04810 Regulation of actin cytoskeleton ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05222 Small cell lung cancer ko05410 Hypertrophic cardiomyopathy (HCM) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05414 Dilated cardiomyopathy (DCM) Vitronectin receptor, alpha subunit W Extracellular structures ; IPR002035 [von Willebrand factor, type A] ; IPR013517[FG-GAP repeat] ; IPR013649[Integrin alpha-2] ; IPR018184[Integrin alpha chain, C-terminal cytoplasmic region, conserved site] -- -- P51859 Hepatoma-derived growth factor Hdgf 3408.4 3468.5 3983.7 3772.2 3840.7 3649.9 0.964289519480058 0.521245243352611 -0.0524617268468398 Nonsignificant None -- -- hepatoma-derived growth factor -- -- Transcription coactivator K Transcription ; IPR000313 [PWWP domain] -- -- P61211 ADP-ribosylation factor-like protein 1 Arl1 1553.6 1459.7 1187.8 1289.6 1275.5 1377 1.06570102229776 0.491691565362587 0.0918027531561197 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) ADP-ribosylation factor-like protein 1 -- -- GTP-binding ADP-ribosylation factor-like protein ARL1 U Intracellular trafficking, secretion, and vesicular transport ; IPR006689 [Small GTPase superfamily, ARF/SAR type] -- -- Q3UZ17 Uncharacterized protein Luc7l2 2659.6 2840.4 2436.5 2275.8 2252 2253.5 1.17035081768982 0.0803680657843886 0.226941048678355 Nonsignificant None 3 Molecular Function:mRNA binding (GO:0003729),Cellular Component:U1 snRNP (GO:0005685),Biological Process:mRNA splice site selection (GO:0006376) RNA-binding protein Luc7-like 2 -- -- Spliceosome subunit A RNA processing and modification ; IPR004882 [Luc7-related] -- -- Q6ZWN5 40S ribosomal protein S9 Rps9 6123.8 5951.7 5492.3 4514.8 4714 4678.7 1.26318892683804 0.00353482840404552 0.337070429646863 Nonsignificant None 3 Molecular Function:RNA binding (GO:0003723),Cellular Component:intracellular (GO:0005622),Molecular Function:rRNA binding (GO:0019843) small subunit ribosomal protein S9e -- ko03010 Ribosome Ribosomal protein S4 J Translation, ribosomal structure and biogenesis ; IPR001912 [Ribosomal protein S4/S9, N-terminal] ; IPR002942[RNA-binding S4 domain] -- -- Q99J99 3-mercaptopyruvate sulfurtransferase Mpst 1610.9 1524.6 2598.9 1996.4 1624.9 1752.4 1.06712321119527 0.756101988684754 0.0937267609027661 Nonsignificant None -- -- -- -- ko00270 Cysteine and methionine metabolism ko00920 Sulfur metabolism ko01100 Metabolic pathways ko04122 Sulfur relay system Mercaptopyruvate sulfurtransferase/thiosulfate sulfurtransferase V Defense mechanisms ; IPR001763 [Rhodanese-like domain] -- -- Q569Z6 Thyroid hormone receptor-associated protein 3 Thrap3 3232.3 3240.9 3797.6 3435.5 3507.8 3370.4 0.995840484016405 0.943966359496978 -0.00601342824570937 Nonsignificant None -- -- thyroid hormone receptor-associated protein 3 -- -- -- -- -- IPR029199 [THRAP3/BCLAF1 family] -- -- P08030 Adenine phosphoribosyltransferase Aprt 3277.5 3375.2 2937.9 2670.7 2751.8 2751.4 1.17331995742546 0.0250787214844334 0.230596481437486 Nonsignificant None 1 Biological Process:nucleoside metabolic process (GO:0009116) adenine phosphoribosyltransferase 2.4.2.7 ko00230 Purine metabolism ko01100 Metabolic pathways Adenine phosphoribosyl transferases F Nucleotide transport and metabolism ; IPR000836 [Phosphoribosyltransferase domain] -- -- Q5D098 Proteasome subunit beta (Fragment) Psmb7 4499.2 4323.5 4325.4 4035.5 4086.9 4111.5 1.07472678377296 0.00814304326587356 0.103969945587662 Nonsignificant None 3 Molecular Function:threonine-type endopeptidase activity (GO:0004298),Cellular Component:proteasome core complex (GO:0005839),Biological Process:proteolysis involved in cellular protein catabolic process (GO:0051603) 20S proteasome subunit beta 2 3.4.25.1 ko03050 Proteasome 20S proteasome, regulatory subunit beta type PSMB7/PSMB10/PUP1 O Posttranslational modification, protein turnover, chaperones ; IPR001353 [Proteasome, subunit alpha/beta] ; IPR024689[Proteasome beta subunit, C-terminal] -- -- Q9DCS9 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 Ndufb10 3188.1 3053.5 3525.1 3660.8 3613.3 3680.8 0.891537120375357 0.103022186834387 -0.165633227192399 Nonsignificant None -- -- NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 10 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease NADH-ubiquinone oxidoreductase, subunit NDUFB10/PDSW C Energy production and conversion ; IPR019377 [NADH-ubiquinone oxidoreductase, subunit 10] -- -- Q0VG22 START domain containing 10 Stard10 1777.2 1780.4 1406.5 1830.5 1638.9 1593.5 0.980485492504296 0.83007589777934 -0.0284318107697331 Nonsignificant None 1 Molecular Function:lipid binding (GO:0008289) -- -- -- START domain-containing proteins involved in steroidogenesis/phosphatidylcholine transfer I Lipid transport and metabolism ; IPR002913 [START domain] -- -- Q99KY4 Cyclin-G-associated kinase Gak 2079.6 1969.6 2229.6 2064.8 2103.5 2112.5 0.99968156922685 0.993486177106359 -0.000459471656130173 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) cyclin G-associated kinase 2.7.11.1 -- Clathrin coat dissociation kinase GAK/PTEN/Auxilin and related tyrosine phosphatases TR Signal transduction mechanisms ; General function prediction only ; IPR000719 [Protein kinase domain] ; IPR001623[DnaJ domain] ; IPR014020[Tensin phosphatase, C2 domain] -- -- Q548W7 Diazepam binding inhibitor Dbi 5534 5615.4 5825.9 5209.7 5454.8 5200.9 1.06995726549599 0.0371541310024544 0.0975531759832257 Nonsignificant None 1 Molecular Function:fatty-acyl-CoA binding (GO:0000062) diazepam-binding inhibitor (GABA receptor modulator, acyl-CoA-binding protein) -- ko03320 PPAR signaling pathway Acyl-CoA-binding protein I Lipid transport and metabolism ; IPR000582 [Acyl-CoA-binding protein, ACBP] -- -- Q571J7 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B (Fragment) Ppp2r2a 2375.4 2394 2388.7 2399 2385.4 2361.8 1.00166522067672 0.761269901845733 0.00240040756236667 Nonsignificant None -- -- serine/threonine-protein phosphatase 2A regulatory subunit B -- ko03015 mRNA surveillance pathway ko04071 Sphingolipid signaling pathway ko04151 PI3K-Akt signaling pathway ko04152 AMPK signaling pathway ko04261 Adrenergic signaling in cardiomyocytes ko04390 Hippo signaling pathway ko04530 Tight junction ko04728 Dopaminergic synapse ko05142 Chagas disease (American trypanosomiasis) ko05160 Hepatitis C ko05165 Human papillomavirus infection Serine/threonine protein phosphatase 2A, regulatory subunit T Signal transduction mechanisms ; -- -- -- Q3UHW5 Uncharacterized protein Rab8a 920.8 802 803.7 841.4 831.7 890.9 0.985374414976599 0.78756002795475 -0.0212560820007883 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-8A -- ko04144 Endocytosis ko04152 AMPK signaling pathway ko04530 Tight junction ko04972 Pancreatic secretion GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- A7YY80 130kDa Protein 4.1B MEF cell isoform Epb41l3 1892.5 1670.9 1920.8 2029.8 1956.9 2082.3 0.903641456582633 0.0884900635706165 -0.146177635760819 Nonsignificant None 5 Molecular Function:actin binding (GO:0003779),Molecular Function:structural molecule activity (GO:0005198),Cellular Component:cytoskeleton (GO:0005856),Molecular Function:cytoskeletal protein binding (GO:0008092),Biological Process:cortical actin cytoskeleton organization (GO:0030866) erythrocyte membrane protein band 4.1 -- -- Erythrocyte membrane protein 4.1 and related proteins of the ERM family R General function prediction only ; IPR007477 [SAB domain] ; IPR008379[Band 4.1, C-terminal] ; IPR014847[FERM adjacent (FA)] ; IPR018979[FERM, N-terminal] ; IPR018980[FERM, C-terminal PH-like domain] ; IPR019748[FERM central domain] -- -- B2RUJ2 Erbb2ip protein Erbin 2610.7 2508.7 2785.2 2840.8 2767.4 2807 0.939324080235764 0.111056923136862 -0.0903051007099382 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) erbb2-interacting protein -- ko04621 NOD-like receptor signaling pathway FOG: Leucine rich repeat R General function prediction only ; IPR001478 [PDZ domain] ; IPR001611[Leucine-rich repeat] -- -- Q8VI75 Importin-4 Ipo4 2251.3 2354.3 2291.4 2114.2 2081.1 2055.8 1.10332581465662 0.00332973409500074 0.141858885017167 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Biological Process:intracellular protein transport (GO:0006886),Molecular Function:Ran GTPase binding (GO:0008536) importin-4 -- -- Karyopherin (importin) beta 3 YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; IPR000357 [HEAT repeat] ; IPR001494[Importin-beta, N-terminal domain] -- -- Q8K0J2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 B3gnt7 2629.6 2405.3 2032.9 3299.6 3481.7 3707.3 0.673855423984135 0.0055996826711726 -0.569489001217461 Nonsignificant None 3 Biological Process:protein glycosylation (GO:0006486),Molecular Function:galactosyltransferase activity (GO:0008378),Cellular Component:membrane (GO:0016020) beta-1,3-N-acetylglucosaminyltransferase 7 2.4.1.- ko00533 Glycosaminoglycan biosynthesis - keratan sulfate Galactosyltransferases G Carbohydrate transport and metabolism ; IPR002659 [Glycosyl transferase, family 31] -- -- Q3UW40 TRASH domain-containing protein Rpl24 6755.1 6709.7 6048.4 5147.8 5106.8 5296.4 1.25478747347437 0.00496780441404403 0.327443031961825 Nonsignificant None -- -- large subunit ribosomal protein L24e -- ko03010 Ribosome 60s ribosomal protein L24 J Translation, ribosomal structure and biogenesis ; IPR000988 [Ribosomal protein L24e-related] -- -- K3W4Q8 Basigin Bsg 2463 2615.5 2647.5 3261.1 3227.8 3108.2 0.805034854278897 0.00105468731295925 -0.312876848297663 Nonsignificant None -- -- basigin -- -- -- -- -- -- -- -- Q8BVE3 V-type proton ATPase subunit H Atp6v1h 2246.7 2277.7 2349.1 2127.5 2253.3 2121.3 1.05712000738223 0.0782690111776524 0.0801391650152954 Nonsignificant None 1 Biological Process:ATP hydrolysis coupled proton transport (GO:0015991) V-type H+-transporting ATPase subunit H -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04142 Lysosome ko04145 Phagosome ko04150 mTOR signaling pathway ko04721 Synaptic vesicle cycle ko05152 Tuberculosis ko05323 Rheumatoid arthritis Vacuolar H+-ATPase V1 sector, subunit H C Energy production and conversion ; IPR011987 [ATPase, V1 complex, subunit H, C-terminal] -- -- Q8C570 mRNA export factor Rae1 3269.2 3394.9 3231.9 3066.8 3197.4 3110.1 1.05565215536093 0.0496972348177697 0.0781345350699141 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) mRNA export factor -- ko03013 RNA transport ko05164 Influenza A mRNA export protein (contains WD40 repeats) A RNA processing and modification ; IPR001680 [WD40 repeat] -- -- Q8JZK9 Hydroxymethylglutaryl-CoA synthase, cytoplasmic Hmgcs1 1835.4 1787.9 2124.1 2288.1 2807 2623.9 0.744578313253012 0.0236317597424581 -0.425504498329913 Nonsignificant None 2 Molecular Function:hydroxymethylglutaryl-CoA synthase activity (GO:0004421),Biological Process:isoprenoid biosynthetic process (GO:0008299) hydroxymethylglutaryl-CoA synthase 2.3.3.10 ko00072 Synthesis and degradation of ketone bodies ko00280 Valine, leucine and isoleucine degradation ko00650 Butanoate metabolism ko00900 Terpenoid backbone biosynthesis ko01100 Metabolic pathways Hydroxymethylglutaryl-CoA synthase I Lipid transport and metabolism ; IPR013528 [Hydroxymethylglutaryl-coenzyme A synthase, N-terminal] ; IPR013746[Hydroxymethylglutaryl-coenzyme A synthase C-terminal domain] -- -- D3YYT1 Putative oxidoreductase GLYR1 Glyr1 1322.5 1330.5 1311.9 1273.1 1260.2 1249.2 1.04822207534699 0.00226214984777383 0.0679443972770505 Nonsignificant None 3 Molecular Function:phosphogluconate dehydrogenase (decarboxylating) activity (GO:0004616),Molecular Function:NAD binding (GO:0051287),Biological Process:oxidation-reduction process (GO:0055114) -- -- -- Predicted dehydrogenase R General function prediction only ; IPR000313 [PWWP domain] ; IPR006115[6-phosphogluconate dehydrogenase, NADP-binding] ; IPR029154[3-hydroxyisobutyrate dehydrogenase, NAD-binding domain] -- -- Q3UZG4 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 Aimp1 2811.4 2810.7 2504.9 2434.8 2562.6 2464.1 1.08919118139784 0.111851765289928 0.12325720680659 Nonsignificant None 1 Molecular Function:tRNA binding (GO:0000049) aminoacyl tRNA synthase complex-interacting multifunctional protein 1 -- -- tRNA-binding protein J Translation, ribosomal structure and biogenesis ; IPR002547 [tRNA-binding domain] -- -- Q3UK30 Uncharacterized protein 2019.5 1788.8 1546 1526.2 1562.4 1600.5 1.14186091147555 0.244469350270581 0.191386928682214 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:zinc ion binding (GO:0008270) RNA-binding protein FUS -- ko05202 Transcriptional misregulation in cancer Conserved Zn-finger protein R General function prediction only ; IPR000504 [RNA recognition motif domain] ; IPR001876[Zinc finger, RanBP2-type] -- -- Q9CQR2 40S ribosomal protein S21 Rps21 2566.6 2663 2300 2295.2 2504.8 2165.8 1.08093829854432 0.269585945033784 0.112284174391091 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S21e -- ko03010 Ribosome 40S ribosomal protein S21 J Translation, ribosomal structure and biogenesis ; IPR001931 [Ribosomal protein S21e] -- -- A7VJ98 Glia maturation factor Gmfb 1187.7 1148.3 1230.1 1224.8 1285.3 1261.3 0.945563981545315 0.0807965520705314 -0.080753013512825 Nonsignificant None 2 Molecular Function:actin binding (GO:0003779),Cellular Component:intracellular (GO:0005622) -- -- -- Glia maturation factor beta W Extracellular structures ; IPR002108 [Actin-depolymerising factor homology domain] -- -- Q3TFP8 Cytochrome b5 heme-binding domain-containing protein Pgrmc1 1565.3 1557 2057.6 1921.7 1900.2 1913.5 0.903145377828922 0.379546105878455 -0.146969860236029 Nonsignificant None -- -- membrane-associated progesterone receptor component -- -- Putative steroid membrane receptor Hpr6.6/25-Dx R General function prediction only ; IPR001199 [Cytochrome b5-like heme/steroid binding domain] -- -- Q9WUM3 Coronin-1B Coro1b 3160.4 3106.1 3530.3 3967 3952.6 3646.2 0.847049058430891 0.0253454374676326 -0.239482566527824 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) coronin-1B/1C/6 -- -- Actin-binding protein Coronin, contains WD40 repeats Z Cytoskeleton ; IPR001680 [WD40 repeat] ; IPR015048[Domain of unknown function DUF1899] -- -- Q3V453 14_3_3 domain-containing protein (Fragment) Ywhae 33.8 30 39 86.1 67.7 69.5 0.460367218987909 0.00331158654623783 -1.1191429866286 Significant down -- -- 14-3-3 protein epsilon -- ko04110 Cell cycle ko04114 Oocyte meiosis ko04151 PI3K-Akt signaling pathway ko04390 Hippo signaling pathway ko04722 Neurotrophin signaling pathway ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis Multifunctional chaperone (14-3-3 family) O Posttranslational modification, protein turnover, chaperones ; IPR023410 [14-3-3 domain] -- -- Q3UIB5 Uncharacterized protein Dhrs4 3157.4 2841.7 3369.6 3723.3 3599.3 3928.4 0.83269931561639 0.0256261591154993 -0.264132456656271 Nonsignificant None -- -- dehydrogenase/reductase SDR family member 4 1.1.-.- ko00830 Retinol metabolism ko01100 Metabolic pathways ko04146 Peroxisome Reductases with broad range of substrate specificities R General function prediction only ; -- -- -- Q8C878 NEDD8-activating enzyme E1 catalytic subunit Uba3 2247.4 2216.8 2250 2304.5 2400.3 2369.1 0.949151104765405 0.0164572383479054 -0.0752903124437745 Nonsignificant None 4 Molecular Function:ATP binding (GO:0005524),Molecular Function:small protein activating enzyme activity (GO:0008641),Molecular Function:acid-amino acid ligase activity (GO:0016881),Biological Process:protein neddylation (GO:0045116) ubiquitin-activating enzyme E1 C 6.2.1.45 ko04120 Ubiquitin mediated proteolysis NEDD8-activating complex, catalytic component UBA3 O Posttranslational modification, protein turnover, chaperones ; IPR000594 [THIF-type NAD/FAD binding fold] ; IPR014929[E2 binding] -- -- B2RPS1 RAB5B, member RAS oncogene family Rab5b 862.6 857.5 923.4 1071.8 998 1035.2 0.851368760064412 0.00687561955709893 -0.232143941726902 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-5B -- ko04014 Ras signaling pathway ko04144 Endocytosis ko04145 Phagosome ko04962 Vasopressin-regulated water reabsorption ko05146 Amoebiasis ko05152 Tuberculosis GTPase Rab5/YPT51 and related small G protein superfamily GTPases U Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- Q9QWR8 Alpha-N-acetylgalactosaminidase Naga 2813.6 2745.5 2995.9 3818 3608.1 4046.4 0.745696230115494 0.0027059549085836 -0.423340046922859 Nonsignificant None 1 Biological Process:carbohydrate metabolic process (GO:0005975) alpha-N-acetylgalactosaminidase 3.2.1.49 ko00603 Glycosphingolipid biosynthesis - globo and isoglobo series ko04142 Lysosome Alpha-D-galactosidase (melibiase) G Carbohydrate transport and metabolism ; IPR002241 [Glycoside hydrolase, family 27] -- -- P24472 Glutathione S-transferase A4 Gsta4 1591.4 1454.1 1589.5 1895.4 1577.6 2387.2 0.790928637247876 0.163829835195051 -0.338380563695082 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) glutathione S-transferase 2.5.1.18 ko00480 Glutathione metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko01524 Platinum drug resistance ko05200 Pathways in cancer ko05204 Chemical carcinogenesis ko05225 Hepatocellular carcinoma ko05418 Fluid shear stress and atherosclerosis Glutathione S-transferase O Posttranslational modification, protein turnover, chaperones ; IPR004045 [Glutathione S-transferase, N-terminal] ; IPR004046[Glutathione S-transferase, C-terminal] -- -- Q61171 Peroxiredoxin-2 Prdx2 5332.8 5167 6033.3 5901.1 5772.2 5852.5 0.943357792511612 0.338377270110858 -0.0841230412918322 Nonsignificant None 4 Molecular Function:antioxidant activity (GO:0016209),Molecular Function:oxidoreductase activity (GO:0016491),Molecular Function:peroxiredoxin activity (GO:0051920),Biological Process:oxidation-reduction process (GO:0055114) peroxiredoxin (alkyl hydroperoxide reductase subunit C) 1.11.1.15 Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes O Posttranslational modification, protein turnover, chaperones ; IPR000866 [Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant] ; IPR019479[Peroxiredoxin, C-terminal] -- -- Q9CRB6 Tubulin polymerization-promoting protein family member 3 Tppp3 2830.3 2734.8 3565.5 4320.7 3796.9 4372.5 0.731026973362903 0.0250121864902807 -0.452003455304781 Nonsignificant None -- -- -- -- -- Putative signal transduction protein p25 RT General function prediction only ; Signal transduction mechanisms ; IPR008907 [P25-alpha] -- -- Q8R2S8 CD177 antigen Cd177 1289.1 1608.1 1376.2 1215.3 1190.9 1258.6 1.16606636105654 0.105259948503362 0.221649894921658 Nonsignificant None -- -- CD177 antigen -- -- -- -- -- IPR016054 [Ly-6 antigen/uPA receptor-like] -- -- P63094 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Gnas 2333.3 2520.3 2767 2703.5 2625.9 2653.5 0.954615490611181 0.397612673706522 -0.067008347595708 Nonsignificant None 5 Molecular Function:GTPase activity (GO:0003924),Molecular Function:signal transducer activity (GO:0004871),Biological Process:G-protein coupled receptor signaling pathway (GO:0007186),Molecular Function:guanyl nucleotide binding (GO:0019001),Molecular Function:G-protein beta/gamma-subunit complex binding (GO:0031683) guanine nucleotide-binding protein G(s) subunit alpha -- ko01522 Endocrine resistance ko04015 Rap1 signaling pathway ko04020 Calcium signaling pathway ko04024 cAMP signaling pathway ko04072 Phospholipase D signaling pathway ko04261 Adrenergic signaling in cardiomyocytes ko04270 Vascular smooth muscle contraction ko04540 Gap junction ko04611 Platelet activation ko04713 Circadian entrainment ko04724 Glutamatergic synapse ko04726 Serotonergic synapse ko04728 Dopaminergic synapse ko04730 Long-term depression ko04750 Inflammatory mediator regulation of TRP channels ko04911 Insulin secretion ko04912 GnRH signaling pathway ko04913 Ovarian steroidogenesis ko04915 Estrogen signaling pathway ko04916 Melanogenesis ko04918 Thyroid hormone synthesis ko04921 Oxytocin signaling pathway ko04922 Glucagon signaling pathway ko04923 Regulation of lipolysis in adipocytes ko04924 Renin secretion ko04925 Aldosterone synthesis and secretion ko04926 Relaxin signaling pathway ko04961 Endocrine and other factor-regulated calcium reabsorption ko04962 Vasopressin-regulated water reabsorption ko04970 Salivary secretion ko04971 Gastric acid secretion ko04972 Pancreatic secretion ko04976 Bile secretion ko05030 Cocaine addiction ko05031 Amphetamine addiction ko05032 Morphine addiction ko05034 Alcoholism ko05142 Chagas disease (American trypanosomiasis) ko05146 Amoebiasis ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05414 Dilated cardiomyopathy (DCM) G protein subunit Galphas, small G protein superfamily T Signal transduction mechanisms ; IPR001019 [Guanine nucleotide binding protein (G-protein), alpha subunit] -- -- P42125 Enoyl-CoA delta isomerase 1, mitochondrial Eci1 2299.4 2210.2 2769 3115.8 2878 3146.8 0.796293459947925 0.0324083093774525 -0.3286278862433 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) 3,2-trans-enoyl-CoA isomerase, mitochondrial 5.3.3.8 ko00071 Fatty acid degradation Hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase I Lipid transport and metabolism ; IPR001753 [Crotonase superfamily] -- -- Q52L97 Importin subunit alpha Kpna2 2473.7 2571.6 2093.9 1705.2 1755.6 1826.6 1.35022884593562 0.0146312386457478 0.433203945732715 Nonsignificant None 5 Molecular Function:protein binding (GO:0005515),Cellular Component:nucleus (GO:0005634),Cellular Component:cytoplasm (GO:0005737),Biological Process:protein import into nucleus (GO:0006606),Molecular Function:protein transporter activity (GO:0008565) importin subunit alpha-2 -- ko05164 Influenza A Karyopherin (importin) alpha U Intracellular trafficking, secretion, and vesicular transport ; IPR000225 [Armadillo] ; IPR002652[Importin-alpha, importin-beta-binding domain] ; IPR032413[Atypical Arm repeat] -- -- Q99L45 Eukaryotic translation initiation factor 2 subunit 2 Eif2s2 4909.5 4695.9 4249.6 3749.6 3953.1 3940.3 1.18998539895216 0.0229096945161311 0.250943871862175 Nonsignificant None 2 Molecular Function:translation initiation factor activity (GO:0003743),Biological Process:translational initiation (GO:0006413) translation initiation factor 2 subunit 2 -- ko03013 RNA transport Translation initiation factor 2, beta subunit (eIF-2beta) J Translation, ribosomal structure and biogenesis ; IPR002735 [Translation initiation factor IF2/IF5] -- -- P63321 Ras-related protein Ral-A Rala 996.3 933.8 920.4 874.6 874.6 933.8 1.0624301155423 0.142125352417049 0.0873679468725402 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Ral-A -- ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04072 Phospholipase D signaling pathway ko05200 Pathways in cancer ko05210 Colorectal cancer ko05212 Pancreatic cancer Ras-related GTPase R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- Q6ZPX7 Non-specific serine/threonine protein kinase (Fragment) mKIAA1101 1654.4 1677.1 2041.4 1994.4 2020.7 1965.4 0.89840314354987 0.246403540677719 -0.154565119090217 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) serine/threonine-protein kinase OSR1/STK39 2.7.11.1 -- Ste20-like serine/threonine protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR024678[Serine/threonine-protein kinase OSR1/WNK, CCT domain] -- -- E9Q634 Unconventional myosin-Ie Myo1e 2488.9 2493.5 2541.5 2427.3 2535.9 2513.2 1.00635332512974 0.691537544700944 0.00913691639442885 Nonsignificant None 4 Molecular Function:motor activity (GO:0003774),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Cellular Component:myosin complex (GO:0016459) myosin I -- -- Myosin class I heavy chain Z Cytoskeleton ; IPR001452 [SH3 domain] ; IPR001609[Myosin head, motor domain] ; IPR010926[Class I myosin tail homology domain] -- -- P51658 Estradiol 17-beta-dehydrogenase 2 Hsd17b2 2816.1 2585.8 4089.2 4126.9 4548.2 4376 0.727226057573691 0.0700152781322723 -0.459524200554978 Nonsignificant None -- -- -- -- ko00140 Steroid hormone biosynthesis ko01100 Metabolic pathways ko04913 Ovarian steroidogenesis Corticosteroid 11-beta-dehydrogenase and related short chain-type dehydrogenases QR Secondary metabolites biosynthesis, transport and catabolism ; General function prediction only ; IPR002347 [Short-chain dehydrogenase/reductase SDR] -- -- O54984 ATPase GET3 Get3 2439.3 2378.5 2513.7 2448.6 2459.2 2390.3 1.00457653361834 0.815082583620195 0.00658747991546971 Nonsignificant None -- -- -- -- -- Putative arsenite-translocating ATPase P Inorganic ion transport and metabolism ; IPR025723 [Anion-transporting ATPase-like domain] -- -- E9QP99 Golgin subfamily A member 3 Golga3 1359.6 1318.2 1418 1502.6 1477.7 1480.1 0.918258452156757 0.0154879880750008 -0.123027824509227 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- P62897 Cytochrome c, somatic Cycs 4394 4214.1 3377.5 3572.9 3559.5 3678.4 1.10866910866911 0.337278006513617 0.148828845649906 Nonsignificant None 2 Molecular Function:electron carrier activity (GO:0009055),Molecular Function:heme binding (GO:0020037) cytochrome c -- ko00920 Sulfur metabolism ko01100 Metabolic pathways ko01524 Platinum drug resistance ko04115 p53 signaling pathway ko04210 Apoptosis ko04215 Apoptosis - multiple species ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05014 Amyotrophic lateral sclerosis (ALS) ko05016 Huntington's disease ko05134 Legionellosis ko05145 Toxoplasmosis ko05152 Tuberculosis ko05161 Hepatitis B ko05164 Influenza A ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection ko05200 Pathways in cancer ko05210 Colorectal cancer ko05222 Small cell lung cancer ko05416 Viral myocarditis Cytochrome c C Energy production and conversion ; IPR009056 [Cytochrome c-like domain] -- -- P40240 CD9 antigen Cd9 384.7 410.9 408.6 773.4 686.7 818.5 0.52848240147459 0.000825886906247014 -0.92007266439211 Significant down 1 Cellular Component:integral component of membrane (GO:0016021) CD9 antigen -- ko04640 Hematopoietic cell lineage Tetraspanin family integral membrane protein R General function prediction only ; IPR018499 [Tetraspanin/Peripherin] -- -- Q2HZ94 Macrophage mannose receptor 1 Mrc1 2927.4 3012.9 2928.9 2968.7 3398.9 3100.3 0.936765280579643 0.200568092037996 -0.094240488800366 Nonsignificant None -- -- mannose receptor, C type -- ko04145 Phagosome ko05152 Tuberculosis C-type lectin TV Signal transduction mechanisms ; Defense mechanisms ; IPR000562 [Fibronectin, type II, collagen-binding] ; IPR000772[Ricin B, lectin domain] ; IPR001304[C-type lectin-like] -- -- Q9Z2C5 Myotubularin Mtm1 1351.2 1226.6 1333.7 1276.7 1257.3 1322.5 1.01426163619863 0.694944355600463 0.0204298540746307 Nonsignificant None -- -- -- -- ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system Phosphatidylinositol 3-phosphate 3-phosphatase myotubularin MTM1 IU Lipid transport and metabolism ; Intracellular trafficking, secretion, and vesicular transport ; IPR004182 [GRAM domain] ; IPR010569[Myotubularin-like phosphatase domain] -- -- P35980 60S ribosomal protein L18 Rpl18 4573.9 4546.8 4351.3 3972.4 3862 3694.5 1.16854166485961 0.00375520609130224 0.224709174954896 Nonsignificant None -- -- large subunit ribosomal protein L18e -- ko03010 Ribosome 60s ribosomal protein L18 J Translation, ribosomal structure and biogenesis ; IPR021131 [Ribosomal protein L18e/L15P] -- -- Q5SWN2 Replication protein A subunit Rpa1 2486.4 2367.9 2186.8 1831.7 1866.7 2022.2 1.23083243016467 0.0137654275634608 0.299634361638631 Nonsignificant None 4 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634),Biological Process:DNA replication (GO:0006260) replication factor A1 -- ko03030 DNA replication ko03420 Nucleotide excision repair ko03430 Mismatch repair ko03440 Homologous recombination ko03460 Fanconi anemia pathway Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins L Replication, recombination and repair ; IPR004365 [OB-fold nucleic acid binding domain, AA-tRNA synthetase-type] ; IPR007199[Replication factor-A protein 1, N-terminal] ; IPR013955[Replication factor A, C-terminal] ; IPR031657[Replication protein A, OB domain] -- -- Q6DFZ2 Nesprin-2 (Fragment) Syne2 189.4 227.8 36.5 383.9 467 258.4 0.408996664563238 0.060342348944294 -1.28983901709368 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:integral component of membrane (GO:0016021) nesprin-2 -- -- Dystonin, GAS (Growth-arrest-specific protein), and related proteins Z Cytoskeleton ; IPR002017 [Spectrin repeat] ; IPR012315[KASH domain] -- -- Q99KV1 DnaJ homolog subfamily B member 11 Dnajb11 2436.7 2416.3 2682.1 2472 2606.6 2350.2 1.0143091751023 0.769585914984242 0.0204974722619943 Nonsignificant None -- -- DnaJ homolog subfamily B member 11 -- ko04141 Protein processing in endoplasmic reticulum Molecular chaperone (DnaJ superfamily) O Posttranslational modification, protein turnover, chaperones ; IPR001623 [DnaJ domain] ; IPR002939[Chaperone DnaJ, C-terminal] -- -- Q8BVI4 Dihydropteridine reductase Qdpr 3921 3809.6 4866.4 4833.4 4732 4963.5 0.86703053913235 0.132723372920869 -0.205845284970986 Nonsignificant None -- -- dihydropteridine reductase 1.5.1.34 ko00790 Folate biosynthesis ko01100 Metabolic pathways Dihydropteridine reductase DHPR/QDPR E Amino acid transport and metabolism ; IPR002347 [Short-chain dehydrogenase/reductase SDR] -- -- Q9DCJ5 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 Ndufa8 4342.2 4132.2 4925.2 6469.5 5052.7 5265.9 0.798160601854885 0.0871201052685329 -0.325249027402982 Nonsignificant None -- -- NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 8 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease NADH:ubiquinone oxidoreductase, NDUFA8/PGIV/19 kDa subunit C Energy production and conversion ; IPR010625 [CHCH] -- -- Q9Z130 Heterogeneous nuclear ribonucleoprotein D-like Hnrnpdl 2195.3 2002.5 1845.5 1539.3 1659 1704.4 1.23264731678463 0.0277998557139714 0.301760077024225 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) heterogeneous nuclear ribonucleoprotein A/B/D -- -- FOG: RRM domain R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- P27601 Guanine nucleotide-binding protein subunit alpha-13 Gna13 1883.5 1937.6 2237.9 2584 2467.3 2557 0.796367125376234 0.011141157868113 -0.328494428117743 Nonsignificant None 5 Molecular Function:GTPase activity (GO:0003924),Molecular Function:signal transducer activity (GO:0004871),Biological Process:G-protein coupled receptor signaling pathway (GO:0007186),Molecular Function:guanyl nucleotide binding (GO:0019001),Molecular Function:G-protein beta/gamma-subunit complex binding (GO:0031683) guanine nucleotide-binding protein subunit alpha-13 -- ko04022 cGMP-PKG signaling pathway ko04071 Sphingolipid signaling pathway ko04072 Phospholipase D signaling pathway ko04270 Vascular smooth muscle contraction ko04371 Apelin signaling pathway ko04611 Platelet activation ko04730 Long-term depression ko04810 Regulation of actin cytoskeleton ko05200 Pathways in cancer G-protein alpha subunit (small G protein superfamily) DT Cell cycle control, cell division, chromosome partitioning ; Signal transduction mechanisms ; IPR001019 [Guanine nucleotide binding protein (G-protein), alpha subunit] -- -- Q9WUP7 Ubiquitin carboxyl-terminal hydrolase isozyme L5 Uchl5 4040.5 3981.7 3443.5 2857.7 3071.2 2868.2 1.30334996760296 0.0117114027671685 0.382224519618498 Nonsignificant None 3 Molecular Function:thiol-dependent ubiquitin-specific protease activity (GO:0004843),Cellular Component:intracellular (GO:0005622),Biological Process:ubiquitin-dependent protein catabolic process (GO:0006511) ubiquitin carboxyl-terminal hydrolase L5 3.4.19.12 -- Ubiquitin C-terminal hydrolase O Posttranslational modification, protein turnover, chaperones ; IPR001578 [Peptidase C12, ubiquitin carboxyl-terminal hydrolase] -- -- A0A2I3BRQ3 Inter-alpha-trypsin inhibitor heavy chain H3 Itih3 3126.2 2994.5 2048.3 1373 1429.9 1289.8 1.99599286534562 0.0552364304981355 0.997106563786949 Nonsignificant None 2 Molecular Function:serine-type endopeptidase inhibitor activity (GO:0004867),Biological Process:hyaluronan metabolic process (GO:0030212) -- -- -- -- -- -- IPR002035 [von Willebrand factor, type A] ; IPR010600[Inter-alpha-trypsin inhibitor heavy chain, C-terminal] ; IPR013694[VIT domain] -- -- A0A0R4J008 Histone deacetylase 2 Hdac2 1100.8 1066.1 960 928.9 963.8 976.9 1.089664064678 0.127514156258262 0.123883431403336 Nonsignificant None -- -- histone deacetylase 1/2 3.5.1.98 ko04110 Cell cycle ko04213 Longevity regulating pathway - multiple species ko04330 Notch signaling pathway ko04919 Thyroid hormone signaling pathway ko05016 Huntington's disease ko05034 Alcoholism ko05165 Human papillomavirus infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05202 Transcriptional misregulation in cancer ko05203 Viral carcinogenesis ko05220 Chronic myeloid leukemia Histone deacetylase complex, catalytic component RPD3 B Chromatin structure and dynamics ; IPR023801 [Histone deacetylase domain] -- -- P31725 Protein S100-A9 S100a9 6339.8 9385 4667 2689.2 2857 2742.8 2.46010375196043 0.0997414233732773 1.29871916080127 Nonsignificant None -- -- protein S100-A9 -- ko04657 IL-17 signaling pathway -- -- -- IPR013787 [S100/CaBP-9k-type, calcium binding, subdomain] -- -- P30677 Guanine nucleotide-binding protein subunit alpha-14 Gna14 1503.4 1420.9 1399.9 1315.4 1458 1373 1.04288057109782 0.318725286941752 0.0605739523444868 Nonsignificant None 5 Molecular Function:GTPase activity (GO:0003924),Molecular Function:signal transducer activity (GO:0004871),Biological Process:G-protein coupled receptor signaling pathway (GO:0007186),Molecular Function:guanyl nucleotide binding (GO:0019001),Molecular Function:G-protein beta/gamma-subunit complex binding (GO:0031683) guanine nucleotide-binding protein subunit alpha-14 -- ko04020 Calcium signaling pathway ko05142 Chagas disease (American trypanosomiasis) ko05146 Amoebiasis G protein subunit Galphaq/Galphay, small G protein superfamily T Signal transduction mechanisms ; IPR001019 [Guanine nucleotide binding protein (G-protein), alpha subunit] -- -- G3XA25 Acetyl-CoA acetyltransferase, cytosolic Acat2 1791.6 1827.8 2048.8 2446 2703.4 2397.2 0.751093207537169 0.00732343521290682 -0.412936143595597 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) acetyl-CoA C-acetyltransferase 2.3.1.9 ko00071 Fatty acid degradation ko00072 Synthesis and degradation of ketone bodies ko00280 Valine, leucine and isoleucine degradation ko00310 Lysine degradation ko00380 Tryptophan metabolism ko00620 Pyruvate metabolism ko00630 Glyoxylate and dicarboxylate metabolism ko00640 Propanoate metabolism ko00650 Butanoate metabolism ko00900 Terpenoid backbone biosynthesis ko01100 Metabolic pathways ko01200 Carbon metabolism ko01212 Fatty acid metabolism Acetyl-CoA acetyltransferase I Lipid transport and metabolism ; IPR020616 [Thiolase, N-terminal] ; IPR020617[Thiolase, C-terminal] -- -- Q8CE80 Calpastatin Cast 3401.9 3793.4 2870.1 2702.2 2837.1 2864.4 1.19773433130645 0.111603038354304 0.260307940337893 Nonsignificant None -- -- calpastatin -- -- -- -- -- IPR001259 [Proteinase inhibitor I27, calpastatin] -- -- P70122 Ribosome maturation protein SBDS Sbds 2845.3 2719.6 2832.7 2899.2 2941.8 2919.3 0.958597308311359 0.0445105862287823 -0.0610032059333094 Nonsignificant None 1 Biological Process:ribosome biogenesis (GO:0042254) ribosome maturation protein SDO1 -- ko03008 Ribosome biogenesis in eukaryotes Predicted exosome subunit J Translation, ribosomal structure and biogenesis ; IPR018978 [Ribosome maturation protein SBDS, C-terminal] ; IPR019783[Ribosome maturation protein SBDS, N-terminal] -- -- Q8K0U4 Heat shock 70 kDa protein 12A Hspa12a 1298.6 1328.6 1437.8 1435.1 1458.8 1428.3 0.94049326731757 0.118769553379248 -0.088510478881923 Nonsignificant None -- -- -- -- -- Molecular chaperones HSP70/HSC70, HSP70 superfamily O Posttranslational modification, protein turnover, chaperones ; -- -- -- A0A2I3BRL8 Predicted gene 7324 Gm7324 456.3 506.4 456.4 471.2 462.8 431.1 1.03955754157205 0.433074955396212 0.0559696164387768 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) heterogeneous nuclear ribonucleoprotein G -- ko03040 Spliceosome -- -- -- IPR000504 [RNA recognition motif domain] ; IPR012604[RBM1CTR] -- -- Q9D5V5 Cullin-5 Cul5 1644.2 1753.4 2034.6 1952.4 1951 1998.8 0.920368676086883 0.309560250688647 -0.119716211307022 Nonsignificant None 2 Biological Process:ubiquitin-dependent protein catabolic process (GO:0006511),Molecular Function:ubiquitin protein ligase binding (GO:0031625) cullin 5 -- ko04120 Ubiquitin mediated proteolysis E3 ubiquitin ligase, Cullin 1 component O Posttranslational modification, protein turnover, chaperones ; IPR001373 [Cullin, N-terminal] ; IPR019559[Cullin protein, neddylation domain] -- -- O08759 Ubiquitin-protein ligase E3A Ube3a 1670.3 1568.1 1636.4 1533.2 1618.1 1545.1 1.03798654288391 0.212188455497456 0.053787739803215 Nonsignificant None 1 Molecular Function:ubiquitin-protein transferase activity (GO:0004842) ubiquitin-protein ligase E3 A 2.3.2.26 ko04120 Ubiquitin mediated proteolysis ko05165 Human papillomavirus infection ko05203 Viral carcinogenesis E3 ubiquitin protein ligase O Posttranslational modification, protein turnover, chaperones ; IPR000569 [HECT domain] ; IPR032353[Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain] -- -- E9QPX1 Collagen alpha-1(XVIII) chain Col18a1 2126.9 2082.9 2076.3 1729.8 1782.4 1684.4 1.2096563137436 0.000363589053635752 0.274597208748601 Nonsignificant None 4 Molecular Function:structural molecule activity (GO:0005198),Molecular Function:protein binding (GO:0005515),Biological Process:cell adhesion (GO:0007155),Cellular Component:extracellular matrix (GO:0031012) collagen, type XVIII, alpha -- ko04974 Protein digestion and absorption Collagens (type XV) W Extracellular structures ; IPR008160 [Collagen triple helix repeat] ; IPR010363[Domain of unknown function DUF959, collagen XVIII, N-terminal] ; IPR010515[Collagenase NC10/endostatin] ; IPR020067[Frizzled domain] -- -- Q3THW5 Histone H2A.V H2az2 2690.3 3039.9 3207.5 3363.9 3294 3240.3 0.902962154735204 0.110213265160908 -0.147262572651899 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) histone H2A -- ko04217 Necroptosis ko05034 Alcoholism ko05322 Systemic lupus erythematosus Histone 2A B Chromatin structure and dynamics ; IPR007125 [Histone H2A/H2B/H3] ; IPR032454[Histone H2A, C-terminal domain] -- -- A6MDD3 CD109 antigen Cd109 2875.8 2819.8 3422.1 3356.6 2774.8 3487.3 0.947913959266845 0.597157082911093 -0.0771719810934048 Nonsignificant None 3 Molecular Function:endopeptidase inhibitor activity (GO:0004866),Cellular Component:extracellular region (GO:0005576),Cellular Component:extracellular space (GO:0005615) CD109 antigen -- -- Alpha-macroglobulin O Posttranslational modification, protein turnover, chaperones ; IPR001599 [Alpha-2-macroglobulin] ; IPR002890[Alpha-2-macroglobulin, N-terminal] ; IPR009048[Alpha-macroglobulin, receptor-binding] ; IPR011625[Alpha-2-macroglobulin, N-terminal 2] ; IPR011626[Alpha-macroglobulin complement component] ; IPR019565[Alpha-2-macroglobulin, thiol-ester bond-forming] -- -- Q3U890 Histidine--tRNA ligase, cytoplasmic Hars 43.6 53.5 38.5 54.7 60.2 42.5 0.861499364675985 0.347759988265883 -0.215078362371142 Nonsignificant None 3 Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation for protein translation (GO:0006418) histidyl-tRNA synthetase 6.1.1.21 ko00970 Aminoacyl-tRNA biosynthesis Histidyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR000738 [WHEP-TRS domain] ; IPR004154[Anticodon-binding] -- -- Q99K30 Epidermal growth factor receptor kinase substrate 8-like protein 2 Eps8l2 2219.1 2137.7 2531.6 2462.7 2431.8 2369.2 0.948332117240525 0.367210543565586 -0.0765356982267567 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) epidermal growth factor receptor kinase substrate 8 -- -- Epidermal growth factor receptor kinase substrate T Signal transduction mechanisms ; IPR001452 [SH3 domain] ; IPR013625[Tensin/EPS8 phosphotyrosine-binding domain] -- -- Q91YP2 Neurolysin, mitochondrial Nln 2596.7 2370.6 2242 2212.1 2425.9 2605.6 0.99526478546579 0.944344818629738 -0.00684769600632828 Nonsignificant None 2 Molecular Function:metalloendopeptidase activity (GO:0004222),Biological Process:proteolysis (GO:0006508) neurolysin 3.4.24.16 ko04614 Renin-angiotensin system Metalloendopeptidase family - saccharolysin & thimet oligopeptidase O Posttranslational modification, protein turnover, chaperones ; IPR001567 [Peptidase M3A/M3B catalytic domain] -- -- Q8VDX8 Histidine--tRNA ligase, cytoplasmic Hars 580.9 652.3 622 481.8 502 520.1 1.23359265908638 0.00753727192922901 0.302866085142503 Nonsignificant None 3 Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation for protein translation (GO:0006418) histidyl-tRNA synthetase 6.1.1.21 ko00970 Aminoacyl-tRNA biosynthesis Histidyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR000738 [WHEP-TRS domain] ; IPR004154[Anticodon-binding] -- -- P47941 Crk-like protein Crkl 1655.3 1640.2 1697.4 1731 1725.6 1816.4 0.946880333775839 0.0516912273843097 -0.0787459846920043 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) proto-oncogene C-crk -- ko04010 MAPK signaling pathway ko04012 ErbB signaling pathway ko04015 Rap1 signaling pathway ko04062 Chemokine signaling pathway ko04510 Focal adhesion ko04666 Fc gamma R-mediated phagocytosis ko04722 Neurotrophin signaling pathway ko04810 Regulation of actin cytoskeleton ko04910 Insulin signaling pathway ko05100 Bacterial invasion of epithelial cells ko05200 Pathways in cancer ko05206 MicroRNAs in cancer ko05211 Renal cell carcinoma ko05220 Chronic myeloid leukemia Crk family adapters T Signal transduction mechanisms ; IPR000980 [SH2 domain] ; IPR001452[SH3 domain] ; IPR011511[Variant SH3 domain] -- -- Q9QY76 Vesicle-associated membrane protein-associated protein B Vapb 5378.1 5320.2 4420 4198.8 4250.8 4304.8 1.18533996111146 0.124903518332729 0.24530089023722 Nonsignificant None -- -- vesicle-associated membrane protein-associated protein B -- ko04979 Cholesterol metabolism VAMP-associated protein involved in inositol metabolism U Intracellular trafficking, secretion, and vesicular transport ; IPR000535 [Major sperm protein (MSP) domain] -- -- Q9D892 Inosine triphosphate pyrophosphatase Itpa 1698.7 1663.4 2010.9 2022.2 1949.7 1947.4 0.907708681769804 0.182727029900612 -0.139698738782259 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) inosine triphosphate pyrophosphatase 3.6.1.- ko00230 Purine metabolism ko00983 Drug metabolism - other enzymes ko01100 Metabolic pathways Inosine triphosphate pyrophosphatase F Nucleotide transport and metabolism ; IPR002637 [Ham1-like protein] -- -- Q99NB1 Acetyl-coenzyme A synthetase 2-like, mitochondrial Acss1 1905.5 1886.8 2245.3 2830.7 2566.3 2870.6 0.730272388601287 0.00784654549372391 -0.453493411187348 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) acetyl-CoA synthetase 6.2.1.1 ko00010 Glycolysis / Gluconeogenesis ko00620 Pyruvate metabolism ko00640 Propanoate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism Acyl-CoA synthetase I Lipid transport and metabolism ; IPR000873 [AMP-dependent synthetase/ligase] ; IPR025110[AMP-binding enzyme C-terminal domain] ; IPR032387[Acetyl-coenzyme A synthetase, N-terminal domain] -- -- Q9Z1T2 Thrombospondin-4 Thbs4 1082.3 921.8 941.3 1340 1277.2 1338.4 0.74461522904237 0.00351583304500446 -0.42543297206454 Nonsignificant None 3 Molecular Function:calcium ion binding (GO:0005509),Cellular Component:extracellular region (GO:0005576),Biological Process:cell adhesion (GO:0007155) thrombospondin 2/3/4/5 -- ko04145 Phagosome ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko05144 Malaria ko05165 Human papillomavirus infection -- -- -- IPR001881 [EGF-like calcium-binding domain] ; IPR003367[Thrombospondin, type 3-like repeat] ; IPR008859[Thrombospondin, C-terminal] ; IPR024665[Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain] -- -- Q3UX10 Tubulin alpha chain-like 3 Tubal3 75.8 76.9 90.7 67.8 74.9 77.7 1.1043557168784 0.244710714747727 0.143204944142571 Nonsignificant None 1 Molecular Function:GTPase activity (GO:0003924) tubulin alpha -- ko04145 Phagosome ko04210 Apoptosis ko04530 Tight junction ko04540 Gap junction Alpha tubulin Z Cytoskeleton ; IPR003008 [Tubulin/FtsZ, GTPase domain] ; IPR018316[Tubulin/FtsZ, 2-layer sandwich domain] -- -- Q3U772 Protein kinase domain-containing protein Csnk1a1 45.2 44.2 43.4 40.3 44.9 37.1 1.08585445625511 0.206340414427097 0.118830742819538 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) casein kinase 1, alpha 2.7.11.1 ko04310 Wnt signaling pathway ko04340 Hedgehog signaling pathway ko05165 Human papillomavirus infection ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer Casein kinase (serine/threonine/tyrosine protein kinase) T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q9Z315 U4/U6.U5 tri-snRNP-associated protein 1 Sart1 3630.8 3710.8 3541.9 3176.5 3182 3219.2 1.1363375340635 0.0010028732685703 0.184391432016938 Nonsignificant None -- -- U4/U6.U5 tri-snRNP-associated protein 1 -- ko03040 Spliceosome U4/U6.U5 snRNP associated protein A RNA processing and modification ; IPR005011 [SNU66/SART1 family] -- -- Q9D2R0 Acetoacetyl-CoA synthetase Aacs 3830 3577.3 4045.2 4752.2 5071.1 4634 0.7921603618933 0.00596846223468854 -0.336135581388672 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) acetoacetyl-CoA synthetase 6.2.1.16 ko00280 Valine, leucine and isoleucine degradation ko00650 Butanoate metabolism Acyl-CoA synthetase I Lipid transport and metabolism ; IPR000873 [AMP-dependent synthetase/ligase] ; IPR032387[Acetyl-coenzyme A synthetase, N-terminal domain] -- -- Q5SX53 Uncharacterized protein Slc25a11 2054.4 1840.3 2128.2 2169 2103.7 2379.6 0.905386107060716 0.155140134695206 -0.143394925951696 Nonsignificant None -- -- solute carrier family 25 (mitochondrial oxoglutarate transporter), member 11 -- -- Mitochondrial oxoglutarate/malate carrier proteins C Energy production and conversion ; IPR018108 [Mitochondrial substrate/solute carrier] -- -- Q8CFX1 GDH/6PGL endoplasmic bifunctional protein H6pd 3085.6 3113.4 3033.6 2617.4 2625.2 2656.4 1.16883149765793 0.0000712552525641631 0.225066961507482 Nonsignificant None 5 Molecular Function:glucose-6-phosphate dehydrogenase activity (GO:0004345),Biological Process:carbohydrate metabolic process (GO:0005975),Biological Process:glucose metabolic process (GO:0006006),Molecular Function:NADP binding (GO:0050661),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00030 Pentose phosphate pathway ko01100 Metabolic pathways ko01200 Carbon metabolism Glucose-6-phosphate 1-dehydrogenase G Carbohydrate transport and metabolism ; IPR006148 [Glucosamine/galactosamine-6-phosphate isomerase] ; IPR022674[Glucose-6-phosphate dehydrogenase, NAD-binding] ; IPR022675[Glucose-6-phosphate dehydrogenase, C-terminal] -- -- Q9D306 Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C Mgat4c 3000.4 3052.3 3641.9 2302.3 2346.8 2171.1 1.42145391630744 0.0107287900105086 0.507367327441447 Nonsignificant None 2 Biological Process:carbohydrate metabolic process (GO:0005975),Cellular Component:membrane (GO:0016020) -- -- ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways -- -- -- IPR006759 [Glycosyl transferase family 54] -- -- Q3ULU3 Branched-chain-amino-acid aminotransferase Bcat2 1960.5 1930.7 2103.2 2310.9 2227.7 2304.9 0.875926061225981 0.00897504546125979 -0.191119000865305 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) branched-chain amino acid aminotransferase 2.6.1.42 ko00270 Cysteine and methionine metabolism ko00280 Valine, leucine and isoleucine degradation ko00290 Valine, leucine and isoleucine biosynthesis ko00770 Pantothenate and CoA biosynthesis ko01100 Metabolic pathways ko01210 2-Oxocarboxylic acid metabolism ko01230 Biosynthesis of amino acids Branched chain aminotransferase BCAT1, pyridoxal phosphate enzymes type IV superfamily E Amino acid transport and metabolism ; IPR001544 [Aminotransferase class IV] -- -- D3YVS1 Smoothelin Smtn 330.7 277.6 315.7 388.9 416.6 361.3 0.791909496057593 0.022701450662069 -0.336592534594758 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- FOG: Calponin homology domain R General function prediction only ; IPR001715 [Calponin homology domain] ; IPR022189[Smoothelin] -- -- B2RSH2 Guanine nucleotide-binding protein G(i) subunit alpha-1 Gnai1 297.8 270.2 303.1 322.2 344.1 328.3 0.875829479187613 0.0272760693799365 -0.19127808519496 Nonsignificant None 5 Molecular Function:GTPase activity (GO:0003924),Molecular Function:signal transducer activity (GO:0004871),Biological Process:G-protein coupled receptor signaling pathway (GO:0007186),Molecular Function:guanyl nucleotide binding (GO:0019001),Molecular Function:G-protein beta/gamma-subunit complex binding (GO:0031683) guanine nucleotide-binding protein G(i) subunit alpha -- ko04015 Rap1 signaling pathway ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04062 Chemokine signaling pathway ko04071 Sphingolipid signaling pathway ko04261 Adrenergic signaling in cardiomyocytes ko04360 Axon guidance ko04371 Apelin signaling pathway ko04540 Gap junction ko04611 Platelet activation ko04670 Leukocyte transendothelial migration ko04713 Circadian entrainment ko04723 Retrograde endocannabinoid signaling ko04724 Glutamatergic synapse ko04725 Cholinergic synapse ko04726 Serotonergic synapse ko04727 GABAergic synapse ko04728 Dopaminergic synapse ko04730 Long-term depression ko04914 Progesterone-mediated oocyte maturation ko04915 Estrogen signaling pathway ko04916 Melanogenesis ko04921 Oxytocin signaling pathway ko04923 Regulation of lipolysis in adipocytes ko04924 Renin secretion ko04926 Relaxin signaling pathway ko04971 Gastric acid secretion ko05012 Parkinson's disease ko05030 Cocaine addiction ko05032 Morphine addiction ko05034 Alcoholism ko05133 Pertussis ko05142 Chagas disease (American trypanosomiasis) ko05145 Toxoplasmosis ko05200 Pathways in cancer G-protein alpha subunit (small G protein superfamily) DT Cell cycle control, cell division, chromosome partitioning ; Signal transduction mechanisms ; IPR001019 [Guanine nucleotide binding protein (G-protein), alpha subunit] -- -- P12787 Cytochrome c oxidase subunit 5A, mitochondrial Cox5a 4989.8 4858.7 5759.4 6219.4 6116.1 6469.5 0.829986705663387 0.0237217820726679 -0.268839866653231 Nonsignificant None 2 Molecular Function:cytochrome-c oxidase activity (GO:0004129),Cellular Component:mitochondrial inner membrane (GO:0005743) cytochrome c oxidase subunit 5a -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04260 Cardiac muscle contraction ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Cytochrome c oxidase, subunit Va/COX6 C Energy production and conversion ; IPR003204 [Cytochrome c oxidase, subunit Va/VI] -- -- H7BX95 Serine/arginine-rich splicing factor 1 Srsf1 4869.7 4936.4 3649.8 3402.2 3442.1 3425.3 1.31026524888993 0.126208598294353 0.389858899183699 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) splicing factor, arginine/serine-rich 1 -- ko03040 Spliceosome ko04657 IL-17 signaling pathway ko05168 Herpes simplex infection Alternative splicing factor ASF/SF2 (RRM superfamily) A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- Q80U72 Protein scribble homolog Scrib 1256.5 1279.9 1432.3 1484.3 1489.1 1573.9 0.872759659578211 0.036415259342409 -0.196343675480044 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) protein scribble -- ko04390 Hippo signaling pathway ko04530 Tight junction ko05165 Human papillomavirus infection ko05203 Viral carcinogenesis FOG: Leucine rich repeat R General function prediction only ; IPR001478 [PDZ domain] ; IPR001611[Leucine-rich repeat] -- -- Q8K154 UDP-glucuronosyltransferase Ugt2b34 3085.8 2827.8 2918.7 3375.5 3315 3380.1 0.877038110936786 0.00623686011058228 -0.189288559783055 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) glucuronosyltransferase 2.4.1.17 ko00040 Pentose and glucuronate interconversions ko00053 Ascorbate and aldarate metabolism ko00140 Steroid hormone biosynthesis ko00830 Retinol metabolism ko00860 Porphyrin and chlorophyll metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko00983 Drug metabolism - other enzymes ko01100 Metabolic pathways ko05204 Chemical carcinogenesis UDP-glucuronosyl and UDP-glucosyl transferase GC Carbohydrate transport and metabolism ; Energy production and conversion ; IPR002213 [UDP-glucuronosyl/UDP-glucosyltransferase] -- -- Q3TW36 Uncharacterized protein Skiv2l 2706 2539.3 1933.4 1880.2 1891.7 1920.7 1.26105821592945 0.168955519938559 0.334634878278401 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) antiviral helicase SKI2 3.6.4.- ko03018 RNA degradation Cytoplasmic exosomal RNA helicase SKI2, DEAD-box superfamily A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR011545[DEAD/DEAH box helicase domain] ; IPR012961[ATP-dependent RNA helicase Ski2, C-terminal] ; IPR025696[rRNA-processing arch domain] -- -- P61965 WD repeat-containing protein 5 Wdr5 1971.7 2029.8 2047.2 1855.6 1854.2 1979.7 1.0631338430442 0.0651333457364695 0.0883232361360072 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) COMPASS component SWD3 -- -- WD40 repeat-containing protein R General function prediction only ; IPR001680 [WD40 repeat] -- -- P61971 Nuclear transport factor 2 Nutf2 2511.4 2389.6 2740.7 2877.5 2834.2 2978.2 0.879377208023107 0.0349807730001883 -0.185445954079073 Nonsignificant None 2 Cellular Component:intracellular (GO:0005622),Biological Process:transport (GO:0006810) -- -- -- Nuclear transport factor 2 U Intracellular trafficking, secretion, and vesicular transport ; IPR002075 [Nuclear transport factor 2] -- -- Q3TAW7 Beta-galactosidase Glb1 1773.1 1764.3 2193.9 2313.7 1927.6 2359.3 0.868299851528649 0.215455752441569 -0.20373475773546 Nonsignificant None -- -- beta-galactosidase 3.2.1.23 ko00052 Galactose metabolism ko00511 Other glycan degradation ko00531 Glycosaminoglycan degradation ko00600 Sphingolipid metabolism ko00604 Glycosphingolipid biosynthesis - ganglio series ko01100 Metabolic pathways ko04142 Lysosome Beta-galactosidase G Carbohydrate transport and metabolism ; IPR025300 [Beta-galactosidase jelly roll domain] ; IPR031330[Glycoside hydrolase 35, catalytic domain] -- -- Q64010 Adapter molecule crk Crk 2328.4 2379.3 2071.1 2265.1 2279.1 2295.4 0.991110591262647 0.851752220381031 -0.0128820480060353 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) proto-oncogene C-crk -- ko04010 MAPK signaling pathway ko04012 ErbB signaling pathway ko04015 Rap1 signaling pathway ko04062 Chemokine signaling pathway ko04510 Focal adhesion ko04666 Fc gamma R-mediated phagocytosis ko04722 Neurotrophin signaling pathway ko04810 Regulation of actin cytoskeleton ko04910 Insulin signaling pathway ko05100 Bacterial invasion of epithelial cells ko05200 Pathways in cancer ko05206 MicroRNAs in cancer ko05211 Renal cell carcinoma ko05220 Chronic myeloid leukemia Crk family adapters T Signal transduction mechanisms ; IPR000980 [SH2 domain] ; IPR001452[SH3 domain] ; IPR011511[Variant SH3 domain] -- -- Q91YR1 Twinfilin-1 Twf1 3007.2 3000.9 3697.4 3181.3 3342.8 3313 0.986622073578595 0.861812677517059 -0.0194305299489014 Nonsignificant None 2 Molecular Function:actin binding (GO:0003779),Cellular Component:intracellular (GO:0005622) twinfilin -- -- Protein tyrosine kinase 9/actin monomer-binding protein W Extracellular structures ; IPR002108 [Actin-depolymerising factor homology domain] -- -- Q6NS46 Protein RRP5 homolog Pdcd11 1227.2 1247.8 1058.4 940.5 982.2 979.4 1.21753213190448 0.0267201558577731 0.283959846991436 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Cellular Component:nucleus (GO:0005634),Biological Process:mRNA processing (GO:0006397) rRNA biogenesis protein RRP5 -- -- rRNA processing protein Rrp5 A RNA processing and modification ; IPR003029 [S1 domain] ; IPR008847[Suppressor of forked] -- -- Q3U844 Protein kinase domain-containing protein Csnk1a1 30.7 29 23.4 26 31.8 27.5 0.974208675263775 0.80686025157786 -0.0376972645479458 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) casein kinase 1, alpha 2.7.11.1 ko04310 Wnt signaling pathway ko04340 Hedgehog signaling pathway ko05165 Human papillomavirus infection ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer Casein kinase (serine/threonine/tyrosine protein kinase) T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q8BHG1 Nardilysin Nrdc 1769.5 1837.2 2119.5 1966.9 2012.8 1902.9 0.973413116649101 0.665305322438301 -0.0388758799616036 Nonsignificant None -- -- nardilysin 3.4.24.61 -- N-arginine dibasic convertase NRD1 and related Zn2+-dependent endopeptidases, insulinase superfamily O Posttranslational modification, protein turnover, chaperones ; IPR007863 [Peptidase M16, C-terminal] ; IPR011765[Peptidase M16, N-terminal] ; IPR032632[Peptidase M16, middle/third domain] -- -- Q8C0E1 Serine/threonine-protein phosphatase 2A activator Ptpa 1472.5 1445.3 1511.7 1651 1701.5 1704 0.876001186591516 0.00127626388243863 -0.190995270850256 Nonsignificant None 1 Molecular Function:phosphatase activator activity (GO:0019211) serine/threonine-protein phosphatase 2A activator -- ko04931 Insulin resistance Phosphotyrosyl phosphatase activator DT Cell cycle control, cell division, chromosome partitioning ; Signal transduction mechanisms ; IPR004327 [Phosphotyrosyl phosphatase activator, PTPA] -- -- Q9Z2H7 PDZ domain-containing protein GIPC2 Gipc2 1585.3 1518.5 1406.7 1570.6 1634.7 1326.7 0.995255957634598 0.949962972450427 -0.00686049252535659 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) PDZ domain-containing protein GIPC -- -- RGS-GAIP interacting protein GIPC, contains PDZ domain TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR001478 [PDZ domain] -- -- A0A7N9VR94 AHNAK nucleoprotein 2 Ahnak2 1420.8 1419.5 1478.7 1774.8 1927.6 1877.4 0.774042080361303 0.00101659539058967 -0.369516095083139 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q5BKQ4 Inactive pancreatic lipase-related protein 1 Pnliprp1 1719.7 1195.3 816.8 983 1573.4 944.4 1.06598491773309 0.827770690922018 0.0921870260280386 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) pancreatic lipase-related protein 1 3.1.1.3 ko00561 Glycerolipid metabolism ko01100 Metabolic pathways ko04972 Pancreatic secretion ko04975 Fat digestion and absorption -- -- -- IPR001024 [PLAT/LH2 domain] ; IPR013818[Lipase/vitellogenin] -- -- Q8K0D5 Elongation factor G, mitochondrial Gfm1 2354.4 2319.8 2410.1 2121.4 2084.6 1984.9 1.14430858195093 0.00357296793955788 0.19447615143317 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) elongation factor G -- -- Mitochondrial elongation factor J Translation, ribosomal structure and biogenesis ; IPR000640 [Translation elongation factor EFG, V domain] ; IPR004161[Translation elongation factor EFTu-like, domain 2] ; IPR005517[Translation elongation factor EFG/EF2, domain IV] ; IPR009022[Elongation factor G, III-V domain] -- -- Q8BSH9 Nucleosome assembly protein 1-like 1 Nap1l1 2181.6 2157.1 1793.6 1579.6 1656.4 1622.5 1.26217968508799 0.0290311641137339 0.33591730836509 Nonsignificant None 2 Cellular Component:nucleus (GO:0005634),Biological Process:nucleosome assembly (GO:0006334) nucleosome assembly protein 1-like 1 -- -- Nucleosome assembly protein NAP-1 BD Chromatin structure and dynamics ; Cell cycle control, cell division, chromosome partitioning ; IPR002164 [Nucleosome assembly protein (NAP)] -- -- Q5M9N5 60S ribosomal protein L28 Rpl28 7918.5 7552.1 5587.4 4715.7 4559.2 4798.4 1.49630861276318 0.0832059133808894 0.581407760910842 Nonsignificant None -- -- large subunit ribosomal protein L28e -- ko03010 Ribosome 60S ribosomal protein L28 J Translation, ribosomal structure and biogenesis ; IPR029004 [Ribosomal L28e/Mak16] -- -- A2A9M4 Dedicator of cytokinesis protein 7 Dock7 1672.7 1761.6 1904.6 1849.7 1847.4 1780.5 0.974678691397692 0.551827659284401 -0.0370013906146576 Nonsignificant None -- -- dedicator of cytokinesis protein 6/7/8 -- -- PH domain-containing protein T Signal transduction mechanisms ; IPR010703 [Dedicator of cytokinesis, C-terminal] ; IPR021816[Dedicator of cytokinesis C/D, N-terminal] ; IPR027007[DHR-1 domain] -- -- Q9DCV1 Dipeptidyl peptidase 1 Ctsc 2278.1 2499.8 2192.3 2508.5 2547 2340.5 0.94242833964305 0.271659026134726 -0.0855451719671293 Nonsignificant None 2 Biological Process:proteolysis (GO:0006508),Molecular Function:cysteine-type peptidase activity (GO:0008234) cathepsin C 3.4.14.1 ko04142 Lysosome ko04210 Apoptosis Cysteine proteinase Cathepsin L O Posttranslational modification, protein turnover, chaperones ; IPR000668 [Peptidase C1A, papain C-terminal] ; IPR014882[Cathepsin C exclusion] -- -- Q4FJN9 Fdps protein Fdps 1887.1 1816 1615.8 1991.1 2137 1923.4 0.878939106006775 0.0763700667207558 -0.186164877761236 Nonsignificant None 1 Biological Process:isoprenoid biosynthetic process (GO:0008299) -- -- ko00900 Terpenoid backbone biosynthesis ko01100 Metabolic pathways ko05164 Influenza A ko05166 HTLV-I infection Polyprenyl synthetase H Coenzyme transport and metabolism ; IPR000092 [Polyprenyl synthetase] -- -- Q60972 Histone-binding protein RBBP4 Rbbp4 1031.2 1149.3 1417.2 1429.8 1483.1 1398 0.834558908812545 0.111657206320201 -0.260914206531174 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) histone-binding protein RBBP4 -- ko04218 Cellular senescence Nucleosome remodeling factor, subunit CAF1/NURF55/MSI1 B Chromatin structure and dynamics ; IPR001680 [WD40 repeat] ; IPR022052[Histone-binding protein RBBP4, N-terminal] -- -- Q921M7 CYFIP-related Rac1 interactor B Cyrib 1033.9 1193.4 1113 978.2 965.8 965 1.14826400825026 0.0878374428914303 0.19945438382875 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR009828 [Protein of unknown function DUF1394] -- -- Q69ZJ6 MKIAA1436 protein (Fragment) Ptgfrn 2223.8 2271.8 2398.6 2452.7 2363.5 2380.9 0.957913604090536 0.161398989273411 -0.0620325522566483 Nonsignificant None -- -- prostaglandin F2 receptor negative regulator -- -- -- -- -- IPR013106 [Immunoglobulin V-set domain] -- -- B7ZP42 Cask protein Cask 3311.1 3268.3 3246.8 3279.6 3252.8 3305.7 0.998790416848782 0.878233451737932 -0.00174611586299212 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) calcium/calmodulin-dependent serine protein kinase 2.7.11.1 -- Calcium/calmodulin-dependent serine protein kinase/membrane-associated guanylate kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR001478[PDZ domain] ; IPR008145[Guanylate kinase/L-type calcium channel beta subunit] ; IPR011511[Variant SH3 domain] ; IPR014775[L27 domain, C-terminal] -- -- G5E8R4 Serine/threonine-protein phosphatase 6 regulatory subunit 3 Ppp6r3 2425.4 2426.8 2911.8 2892.9 2883.3 2883.3 0.896587562792309 0.206495918689663 -0.157483608015277 Nonsignificant None -- -- serine/threonine-protein phosphatase 6 regulatory subunit 3 -- -- SAP family cell cycle dependent phosphatase-associated protein D Cell cycle control, cell division, chromosome partitioning ; IPR007587 [SIT4 phosphatase-associated protein family] -- -- Q3TSR4 Protein NDRG1 Ndrg1 1389.7 1715.6 2260.1 2081.5 2084.4 2135.2 0.851502118677691 0.344095470976044 -0.231917975315904 Nonsignificant None -- -- protein NDRG1 -- -- Differentiation-related gene 1 protein (NDR1 protein), related proteins S Function unknown ; IPR004142 [NDRG] -- -- Q8R055 DNA ligase Lig1 1467.2 1376.2 1330.6 1158.1 1176.5 1138.4 1.20184278721566 0.00495149540763816 0.265248189777743 Nonsignificant None 5 Molecular Function:DNA binding (GO:0003677),Molecular Function:DNA ligase (ATP) activity (GO:0003910),Molecular Function:ATP binding (GO:0005524),Biological Process:DNA repair (GO:0006281),Biological Process:DNA recombination (GO:0006310) -- -- ko03030 DNA replication ko03410 Base excision repair ko03420 Nucleotide excision repair ko03430 Mismatch repair ATP-dependent DNA ligase I L Replication, recombination and repair ; IPR012308 [DNA ligase, ATP-dependent, N-terminal] ; IPR012309[DNA ligase, ATP-dependent, C-terminal] ; IPR012310[DNA ligase, ATP-dependent, central] -- -- E9Q4G8 CD166 antigen Alcam 3118.2 2898.6 3387.4 4203 4015.9 4567.6 0.735478825323583 0.00632190895583665 -0.443244288472392 Nonsignificant None -- -- activated leukocyte cell adhesion molecule -- ko04514 Cell adhesion molecules (CAMs) -- -- -- IPR013162 [CD80-like, immunoglobulin C2-set] -- -- P25799 Nuclear factor NF-kappa-B p105 subunit Nfkb1 1996.9 1959.7 1751.8 1828.3 1783.5 1845.5 1.04601176405915 0.346214525968301 0.0648990770670323 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Molecular Function:protein binding (GO:0005515),Biological Process:signal transduction (GO:0007165) nuclear factor NF-kappa-B p105 subunit -- ko01523 Antifolate resistance ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04024 cAMP signaling pathway ko04062 Chemokine signaling pathway ko04064 NF-kappa B signaling pathway ko04066 HIF-1 signaling pathway ko04071 Sphingolipid signaling pathway ko04151 PI3K-Akt signaling pathway ko04210 Apoptosis ko04211 Longevity regulating pathway ko04218 Cellular senescence ko04380 Osteoclast differentiation ko04620 Toll-like receptor signaling pathway ko04621 NOD-like receptor signaling pathway ko04622 RIG-I-like receptor signaling pathway ko04623 Cytosolic DNA-sensing pathway ko04657 IL-17 signaling pathway ko04658 Th1 and Th2 cell differentiation ko04659 Th17 cell differentiation ko04660 T cell receptor signaling pathway ko04662 B cell receptor signaling pathway ko04668 TNF signaling pathway ko04722 Neurotrophin signaling pathway ko04917 Prolactin signaling pathway ko04920 Adipocytokine signaling pathway ko04926 Relaxin signaling pathway ko04931 Insulin resistance ko04932 Non-alcoholic fatty liver disease (NAFLD) ko04933 AGE-RAGE signaling pathway in diabetic complications ko05030 Cocaine addiction ko05132 Salmonella infection ko05133 Pertussis ko05134 Legionellosis ko05140 Leishmaniasis ko05142 Chagas disease (American trypanosomiasis) ko05145 Toxoplasmosis ko05146 Amoebiasis ko05152 Tuberculosis ko05160 Hepatitis C ko05161 Hepatitis B ko05162 Measles ko05164 Influenza A ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05202 Transcriptional misregulation in cancer ko05203 Viral carcinogenesis ko05206 MicroRNAs in cancer ko05212 Pancreatic cancer ko05215 Prostate cancer ko05220 Chronic myeloid leukemia ko05221 Acute myeloid leukemia ko05222 Small cell lung cancer ko05321 Inflammatory bowel disease (IBD) ko05418 Fluid shear stress and atherosclerosis -- -- -- IPR000488 [Death domain] ; IPR002110[Ankyrin repeat] ; IPR011539[Rel homology domain (RHD), DNA-binding domain] ; IPR020683[Ankyrin repeat-containing domain] ; IPR032397[Rel homology dimerisation domain] -- RHD Q8BW75 Amine oxidase [flavin-containing] B Maob 1737 1729.2 2384.6 3528.6 3083 3628.5 0.571361607796799 0.00595558828010748 -0.807523996138472 Significant down 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) monoamine oxidase 1.4.3.4 ko00260 Glycine, serine and threonine metabolism ko00330 Arginine and proline metabolism ko00340 Histidine metabolism ko00350 Tyrosine metabolism ko00360 Phenylalanine metabolism ko00380 Tryptophan metabolism ko00982 Drug metabolism - cytochrome P450 ko01100 Metabolic pathways ko04726 Serotonergic synapse ko04728 Dopaminergic synapse ko05030 Cocaine addiction ko05031 Amphetamine addiction ko05034 Alcoholism Amine oxidase Q Secondary metabolites biosynthesis, transport and catabolism ; IPR002937 [Amine oxidase] -- -- Q8BH24 Transmembrane 9 superfamily member 4 Tm9sf4 3378.8 3046.2 3058.3 3574.5 3577.4 3628.3 0.879696109534146 0.0172568570293163 -0.184922863166425 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) transmembrane 9 superfamily member 2/4 -- -- Endosomal membrane proteins, EMP70 U Intracellular trafficking, secretion, and vesicular transport ; IPR004240 [Nonaspanin (TM9SF)] -- -- A0A0R4J2B2 BTB/POZ domain-containing protein KCTD12 Kctd12 2541.4 2600.4 2764 2394.5 2495.1 2398.6 1.08473971625367 0.0502043066851201 0.117348908920124 Nonsignificant None 1 Biological Process:protein homooligomerization (GO:0051260) BTB/POZ domain-containing protein KCTD8/12/16 -- -- Uncharacterized conserved protein, contains BTB/POZ domain R General function prediction only ; IPR003131 [Potassium channel tetramerisation-type BTB domain] -- -- Q99LP6 GrpE protein homolog 1, mitochondrial Grpel1 3893.3 3878.4 4395.2 3825.5 3867.2 3898.6 1.049657933105 0.375804060590542 0.0699192530190558 Nonsignificant None 4 Molecular Function:adenyl-nucleotide exchange factor activity (GO:0000774),Biological Process:protein folding (GO:0006457),Molecular Function:protein homodimerization activity (GO:0042803),Molecular Function:chaperone binding (GO:0051087) molecular chaperone GrpE -- -- Molecular chaperone of the GrpE family O Posttranslational modification, protein turnover, chaperones ; IPR000740 [GrpE nucleotide exchange factor] -- -- Q63918 Caveolae-associated protein 2 Cavin2 3322.2 3336.7 4182.6 4561.3 4441.1 4387.7 0.80966534977334 0.0424119287070166 -0.304602357240194 Nonsignificant None -- -- -- -- -- -- -- -- IPR026752 [Cavin family] -- -- Q8BJS4 SUN domain-containing protein 2 Sun2 1585.3 1648.4 1404.3 1577.7 1536.4 1673.6 0.968732376715333 0.583086083202403 -0.0458299350393538 Nonsignificant None -- -- SUN domain-containing protein 1/2 -- -- Spindle pole body protein, contains UNC-84 domain D Cell cycle control, cell division, chromosome partitioning ; IPR012919 [SUN domain] -- -- Q8R5L1 Complement component 1 Q subcomponent-binding protein, mitochondrial C1qbp 2921.3 2874.2 2843.4 2573.8 2680.7 2828.3 1.06880041569753 0.0742135422497658 0.095992474044222 Nonsignificant None 1 Cellular Component:mitochondrial matrix (GO:0005759) complement component 1 Q subcomponent-binding protein, mitochondrial -- ko05168 Herpes simplex infection Complement component 1, Q subcomponent binding protein/mRNA splicing factor SF2, subunit P32 V Defense mechanisms ; IPR003428 [Mitochondrial glycoprotein] -- -- Q60770 Syntaxin-binding protein 3 Stxbp3 2555.4 2487.2 2578.3 2719.7 2697.3 2703.6 0.938465138043987 0.0040916307489106 -0.091624941845302 Nonsignificant None 2 Biological Process:vesicle docking involved in exocytosis (GO:0006904),Biological Process:vesicle-mediated transport (GO:0016192) syntaxin-binding protein 3 -- -- Vesicle trafficking protein Sec1 U Intracellular trafficking, secretion, and vesicular transport ; IPR001619 [Sec1-like protein] -- -- P20060 Beta-hexosaminidase subunit beta Hexb 2133.8 2099.9 2165.1 3896.1 4039.2 4745.7 0.504597429224825 0.0149924125624927 -0.986795238660435 Significant down 1 Biological Process:carbohydrate metabolic process (GO:0005975) hexosaminidase 3.2.1.52 ko00511 Other glycan degradation ko00520 Amino sugar and nucleotide sugar metabolism ko00531 Glycosaminoglycan degradation ko00603 Glycosphingolipid biosynthesis - globo and isoglobo series ko00604 Glycosphingolipid biosynthesis - ganglio series ko01100 Metabolic pathways ko04142 Lysosome Beta-N-acetylhexosaminidase G Carbohydrate transport and metabolism ; IPR015883 [Glycoside hydrolase family 20, catalytic domain] ; IPR029019[Beta-hexosaminidase, eukaryotic type, N-terminal] -- -- Q9CXW3 Calcyclin-binding protein Cacybp 3466.1 3399.6 2740.7 2253.7 2357.6 2343.6 1.38124200204173 0.0596469486133351 0.465966110731656 Nonsignificant None -- -- calcyclin binding protein -- ko04310 Wnt signaling pathway Calcyclin-binding protein CacyBP T Signal transduction mechanisms ; IPR007052 [CS domain] ; IPR007699[SGS domain] ; IPR015120[Siah interacting protein, N-terminal] -- -- Q08331 Calretinin Calb2 3423.5 3115.2 4816.4 4473.1 4897.6 5025.6 0.788751276369623 0.138710771080119 -0.342357660198661 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) -- -- -- Calmodulin and related proteins (EF-Hand superfamily) T Signal transduction mechanisms ; IPR002048 [EF-hand domain] -- -- Q8JZZ5 Phosphatidylinositol transfer protein beta isoform Pitpnb 2414.8 2325.2 2398.1 2481 2421.3 2635.9 0.946923668780345 0.127892626996261 -0.0786799597010077 Nonsignificant None 2 Cellular Component:intracellular (GO:0005622),Biological Process:transport (GO:0006810) -- -- -- Phosphatidylinositol transfer protein IT Lipid transport and metabolism ; Signal transduction mechanisms ; IPR001666 [Phosphatidylinositol transfer protein] -- -- Q8VDP4 Cell cycle and apoptosis regulator protein 2 Ccar2 3427.1 3484.3 3920.7 3640.1 3690.9 3667.2 0.984897528686512 0.756892905994718 -0.0219544642737777 Nonsignificant None -- -- -- -- -- -- -- -- IPR025223 [S1-like RNA binding domain] ; IPR025954[DBC1/CARP1 catalytically inactive NUDIX hydrolase domain] -- -- P28063 Proteasome subunit beta type-8 Psmb8 1670.6 1739.7 1682.9 1824.2 1938.5 1915.4 0.896990190380585 0.00883816541541018 -0.156835887186157 Nonsignificant None 3 Molecular Function:threonine-type endopeptidase activity (GO:0004298),Cellular Component:proteasome core complex (GO:0005839),Biological Process:proteolysis involved in cellular protein catabolic process (GO:0051603) 20S proteasome subunit beta 8 3.4.25.1 ko03050 Proteasome 20S proteasome, regulatory subunit beta type PSMB5/PSMB8/PRE2 O Posttranslational modification, protein turnover, chaperones ; IPR001353 [Proteasome, subunit alpha/beta] -- -- O35226 26S proteasome non-ATPase regulatory subunit 4 Psmd4 230 256.6 204.1 198.4 192.8 203.4 1.16162125798856 0.107018839299932 0.216139760403993 Nonsignificant None -- -- 26S proteasome regulatory subunit N10 -- ko03050 Proteasome ko05169 Epstein-Barr virus infection 26S proteasome regulatory complex, subunit RPN10/PSMD4 O Posttranslational modification, protein turnover, chaperones ; IPR002035 [von Willebrand factor, type A] ; IPR003903[Ubiquitin interacting motif] -- -- F8VPU2 FERM, ARHGEF and pleckstrin domain-containing protein 1 Farp1 2240.6 2275.8 2038.7 2187.1 2205.6 1996.7 1.02593357748771 0.608639133612754 0.0369373288678594 Nonsignificant None 2 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Biological Process:regulation of Rho protein signal transduction (GO:0035023) FERM, RhoGEF and pleckstrin domain-containing protein 1 -- -- Rho guanine nucleotide exchange factor CDEP T Signal transduction mechanisms ; IPR000219 [Dbl homology (DH) domain] ; IPR001849[Pleckstrin homology domain] ; IPR014847[FERM adjacent (FA)] ; IPR018979[FERM, N-terminal] ; IPR018980[FERM, C-terminal PH-like domain] ; IPR019748[FERM central domain] -- -- Q3ULG4 26S proteasome non-ATPase regulatory subunit 4 Psmd4 161.8 153.2 168.7 143.3 150.3 159.4 1.06777041942605 0.188734423000707 0.094601487512265 Nonsignificant None -- -- 26S proteasome regulatory subunit N10 -- ko03050 Proteasome ko05169 Epstein-Barr virus infection 26S proteasome regulatory complex, subunit RPN10/PSMD4 O Posttranslational modification, protein turnover, chaperones ; IPR002035 [von Willebrand factor, type A] ; IPR003903[Ubiquitin interacting motif] -- -- P42669 Transcriptional activator protein Pur-alpha Pura 1656.7 1830 2288.4 2737.8 2729.5 2228.4 0.750432059461777 0.064461470792412 -0.414206631854793 Nonsignificant None -- -- transcriptional activator protein Pur-alpha -- -- Transcriptional regulator of the PUR family, single-stranded-DNA-binding K Transcription ; IPR006628 [Purine-rich element binding protein family] -- -- Q3U518 Glucosidase 2 subunit beta Prkcsh 3159 3043 3664.1 3474.6 3484.1 3441.8 0.948617854910822 0.448895875155478 -0.0761010717694416 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) protein kinase C substrate 80K-H -- ko04141 Protein processing in endoplasmic reticulum Protein kinase C substrate, 80 KD protein, heavy chain T Signal transduction mechanisms ; IPR002048 [EF-hand domain] ; IPR009011[Mannose-6-phosphate receptor binding domain] ; IPR028146[Glucosidase II beta subunit, N-terminal] -- -- Q3UNX5 Acyl-coenzyme A synthetase ACSM3, mitochondrial Acsm3 2159.1 2091.5 2259.8 3607.7 3380.5 3786 0.604258320803401 0.000364339204088444 -0.726762660451903 Significant down 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) medium-chain acyl-CoA synthetase 6.2.1.2 ko00650 Butanoate metabolism ko01100 Metabolic pathways Acyl-CoA synthetase I Lipid transport and metabolism ; IPR000873 [AMP-dependent synthetase/ligase] ; IPR025110[AMP-binding enzyme C-terminal domain] -- -- Q6P8X1 Sorting nexin-6 Snx6 3149.5 3131.6 3433.6 3264.4 3334.7 3340.4 0.977383168167413 0.498645157643645 -0.0330038352081325 Nonsignificant None 1 Molecular Function:phosphatidylinositol binding (GO:0035091) sorting nexin-5/6/32 -- ko04144 Endocytosis Sorting nexin SNX6/TFAF2, contains PX domain V Defense mechanisms ; IPR001683 [Phox homologous domain] ; IPR015404[Sorting nexin Vps5-like, C-terminal] -- -- Q4G0C0 Sec23 interacting protein Sec23ip 2852.2 2726 3498.2 2392.3 2363 2472.2 1.25581459702525 0.120794367832374 0.328623486764532 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:metal ion binding (GO:0046872) -- -- -- Phosphatidic acid-preferring phospholipase A1, contains DDHD domain IU Lipid transport and metabolism ; Intracellular trafficking, secretion, and vesicular transport ; IPR001660 [Sterile alpha motif domain] ; IPR004177[DDHD domain] -- -- Q9JM14 5(3)-deoxyribonucleotidase, cytosolic type Nt5c 2329.4 2386.2 2713.5 3827.5 3782.9 3681.3 0.657925733060567 0.000537384616993784 -0.60400335377222 Significant down 2 Molecular Function:5'-nucleotidase activity (GO:0008253),Biological Process:deoxyribonucleotide catabolic process (GO:0009264) 5'-nucleotidase 3.1.3.5 ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko00760 Nicotinate and nicotinamide metabolism ko01100 Metabolic pathways -- -- -- IPR010708 [5'(3')-deoxyribonucleotidase] -- -- P48774 Glutathione S-transferase Mu 5 Gstm5 1769.2 1691.8 1925.5 2339.7 2367.4 2410.4 0.756796628029505 0.0012975217735286 -0.402022434243814 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) glutathione S-transferase 2.5.1.18 ko00480 Glutathione metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko01524 Platinum drug resistance ko05200 Pathways in cancer ko05204 Chemical carcinogenesis ko05225 Hepatocellular carcinoma ko05418 Fluid shear stress and atherosclerosis Glutathione S-transferase O Posttranslational modification, protein turnover, chaperones ; IPR004045 [Glutathione S-transferase, N-terminal] ; IPR004046[Glutathione S-transferase, C-terminal] -- -- Q8BJW6 Eukaryotic translation initiation factor 2A Eif2a 2545.6 2486.2 2485.7 2174.9 2193.9 2121.5 1.15826695222101 0.00031119601051037 0.211967797593462 Nonsignificant None -- -- translation initiation factor 2A -- -- Predicted translation initiation factor related to eIF-3a J Translation, ribosomal structure and biogenesis ; IPR013979 [Translation initiation factor, beta propellor-like domain] -- -- A2AFG7 Neural cell adhesion molecule L1 L1cam 2110.9 1929.5 2598.6 2516.8 2552.7 2828.2 0.840624485609734 0.132649905683554 -0.250466615136403 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) L1 cell adhesion molecule -- ko04360 Axon guidance ko04514 Cell adhesion molecules (CAMs) Neural cell adhesion molecule L1 T Signal transduction mechanisms ; IPR003961 [Fibronectin type III] ; IPR013098[Immunoglobulin I-set] ; IPR026966[Neurofascin/L1/NrCAM, C-terminal domain] -- -- Q3TGZ3 Isocitrate dehydrogenase [NAD] subunit, mitochondrial Idh3g 2697.4 2707.9 3194 3831.6 3706.9 3911.8 0.751010890544353 0.00550057517612838 -0.413094266215179 Nonsignificant None 1 Biological Process:oxidation-reduction process (GO:0055114) isocitrate dehydrogenase (NAD+) 1.1.1.41 ko00020 Citrate cycle (TCA cycle) ko01100 Metabolic pathways ko01200 Carbon metabolism ko01210 2-Oxocarboxylic acid metabolism ko01230 Biosynthesis of amino acids Isocitrate dehydrogenase, gamma subunit E Amino acid transport and metabolism ; IPR024084 [Isopropylmalate dehydrogenase-like domain] -- -- Q8K010 5-oxoprolinase Oplah 1955.7 1952.3 2256 2416.1 2211.5 2480.8 0.867143098306229 0.0716401669656389 -0.205658004345005 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Molecular Function:hydrolase activity (GO:0016787) 5-oxoprolinase (ATP-hydrolysing) 3.5.2.9 ko00480 Glutathione metabolism Oxoprolinase E Amino acid transport and metabolism ; IPR002821 [Hydantoinase/oxoprolinase] ; IPR003692[Hydantoinase B/oxoprolinase] ; IPR008040[Hydantoinaseoxoprolinase, N-terminal] -- -- Q4FK54 Proteaseome (Prosome, macropain) 28 subunit, 3 Psme3 1878 1770.7 1689.2 1509.2 1541 1450.4 1.18604186108519 0.0100871419976311 0.246154930384946 Nonsignificant None 1 Cellular Component:proteasome activator complex (GO:0008537) proteasome activator subunit 3 (PA28 gamma) -- ko03050 Proteasome ko04612 Antigen processing and presentation ko05160 Hepatitis C Proteasome activator subunit O Posttranslational modification, protein turnover, chaperones ; IPR003185 [Proteasome activator pa28, N-terminal domain] ; IPR003186[Proteasome activator pa28, C-terminal domain] -- -- P42567 Epidermal growth factor receptor substrate 15 Eps15 1312.7 1321.3 1429.5 1381.3 1486 1523.5 0.925457775348456 0.127013512404211 -0.11176092724971 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) epidermal growth factor receptor substrate 15 -- ko04144 Endocytosis Synaptic vesicle protein EHS-1 and related EH domain proteins TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR000261 [EH domain] -- -- Q8R0G9 Nuclear pore complex protein Nup133 Nup133 914.6 977 781.4 786.6 790.1 831.9 1.1097733122976 0.212613268388624 0.150265014752566 Nonsignificant None -- -- nuclear pore complex protein Nup133 -- ko03013 RNA transport Nuclear pore complex, Nup133 component (sc Nup133) YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; IPR007187 [Nucleoporin, Nup133/Nup155-like, C-terminal] -- -- P63280 SUMO-conjugating enzyme UBC9 Ube2i 2391.6 2325.5 3000.9 2664.4 2714.2 2663.9 0.959651849549269 0.665153297123822 -0.0594169869988466 Nonsignificant None -- -- ubiquitin-conjugating enzyme E2 I -- ko03013 RNA transport ko04064 NF-kappa B signaling pathway ko04120 Ubiquitin mediated proteolysis ko05206 MicroRNAs in cancer Ubiquitin-protein ligase O Posttranslational modification, protein turnover, chaperones ; IPR000608 [Ubiquitin-conjugating enzyme E2] -- -- Q9WV02 RNA-binding motif protein, X chromosome Rbmx 246.8 207.4 175.3 165.1 191 219.4 1.09383145091225 0.526075366437293 0.129390449586786 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) heterogeneous nuclear ribonucleoprotein G -- ko03040 Spliceosome -- -- -- IPR000504 [RNA recognition motif domain] ; IPR012604[RBM1CTR] -- -- Q9JKA5 Cell surface A33 antigen Gpa33 3365.5 2951.5 3042.9 3947.2 3886.9 4219.3 0.776536081105746 0.00517506450612221 -0.364875135087423 Nonsignificant None -- -- cell surface A33 antigen -- -- -- -- -- IPR013106 [Immunoglobulin V-set domain] ; IPR013151[Immunoglobulin] -- -- F8WJK8 Hsc70-interacting protein St13 3700.9 3648.5 3726.8 3861.5 3969.5 3661.8 0.963751218153975 0.209786033787673 -0.0532673163332702 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) suppressor of tumorigenicity protein 13 -- -- Hsp70-interacting protein Hip/Transient component of progesterone receptor complexes and an Hsp70-binding protein OT Posttranslational modification, protein turnover, chaperones ; Signal transduction mechanisms ; IPR019734 [Tetratricopeptide repeat] -- -- P63037 DnaJ homolog subfamily A member 1 Dnaja1 4471.5 4723.8 4168.8 3756.3 3758.1 3809 1.18021972199163 0.0498880740209749 0.239055471721536 Nonsignificant None 2 Molecular Function:heat shock protein binding (GO:0031072),Molecular Function:unfolded protein binding (GO:0051082) DnaJ homolog subfamily A member 1 -- ko04141 Protein processing in endoplasmic reticulum Molecular chaperone (DnaJ superfamily) O Posttranslational modification, protein turnover, chaperones ; IPR001305 [Heat shock protein DnaJ, cysteine-rich domain] ; IPR001623[DnaJ domain] ; IPR002939[Chaperone DnaJ, C-terminal] -- -- Q9DBS1 Transmembrane protein 43 Tmem43 3011.1 3119.9 3564.1 3929.1 3833 3755.4 0.841771217712177 0.0262260639782108 -0.248499913758888 Nonsignificant None -- -- -- -- -- -- -- -- IPR012430 [Transmembrane protein 43 family] -- -- Q545G0 Proteasome subunit beta Psmb3 2793.8 2578.7 2522.8 2497.5 2555.6 2649.7 1.02499091239549 0.531324362743935 0.035611118803818 Nonsignificant None 3 Molecular Function:threonine-type endopeptidase activity (GO:0004298),Cellular Component:proteasome core complex (GO:0005839),Biological Process:proteolysis involved in cellular protein catabolic process (GO:0051603) 20S proteasome subunit beta 3 3.4.25.1 ko03050 Proteasome 20S proteasome, regulatory subunit beta type PSMB3/PUP3 O Posttranslational modification, protein turnover, chaperones ; IPR001353 [Proteasome, subunit alpha/beta] -- -- Q6NSR5 UDP-glucuronosyltransferase Ugt1a6a 553.2 540.1 745.7 705.6 712.1 774 0.839074690879226 0.168069794262513 -0.253128855896974 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) glucuronosyltransferase 2.4.1.17 ko00040 Pentose and glucuronate interconversions ko00053 Ascorbate and aldarate metabolism ko00140 Steroid hormone biosynthesis ko00830 Retinol metabolism ko00860 Porphyrin and chlorophyll metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko00983 Drug metabolism - other enzymes ko01100 Metabolic pathways ko05204 Chemical carcinogenesis UDP-glucuronosyl and UDP-glucosyl transferase GC Carbohydrate transport and metabolism ; Energy production and conversion ; IPR002213 [UDP-glucuronosyl/UDP-glucosyltransferase] -- -- O88587 Catechol O-methyltransferase Comt 2021.1 2045.4 1992.2 2097.6 2126.7 2293.7 0.929533599263578 0.0719751881029484 -0.105421080614192 Nonsignificant None 1 Molecular Function:O-methyltransferase activity (GO:0008171) catechol O-methyltransferase 2.1.1.6 ko00140 Steroid hormone biosynthesis ko00350 Tyrosine metabolism ko01100 Metabolic pathways ko04728 Dopaminergic synapse O-methyltransferase Q Secondary metabolites biosynthesis, transport and catabolism ; IPR002935 [O-methyltransferase, family 3] -- -- Q3U893 Uncharacterized protein Cpne1 2045.8 1922.9 1915 2014.7 1983 2093.3 0.965966179609259 0.266486398677872 -0.0499554165552513 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Copine T Signal transduction mechanisms ; IPR000008 [C2 domain] ; IPR010734[Copine] -- -- P62869 Elongin-B Elob 2877.6 2867.8 3068.5 2885.8 2868.2 2674.6 1.04571340436134 0.243817345193591 0.0644875105134067 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) transcription elongation factor B, polypeptide 2 -- ko04066 HIF-1 signaling pathway ko04120 Ubiquitin mediated proteolysis ko05200 Pathways in cancer ko05211 Renal cell carcinoma RNA polymerase II transcription elongation factor Elongin/SIII, subunit elongin B K Transcription ; IPR000626 [Ubiquitin domain] -- -- Q2YDW1 Eif3j protein (Fragment) Eif3j 3304.7 3369.7 2537.4 2592.1 2672.6 2544.8 1.17956335232729 0.220667365571835 0.238252905337828 Nonsignificant None 3 Molecular Function:translation initiation factor activity (GO:0003743),Cellular Component:cytoplasm (GO:0005737),Cellular Component:eukaryotic translation initiation factor 3 complex (GO:0005852) translation initiation factor 3 subunit J -- ko03013 RNA transport Translation initiation factor eIF3, p35 subunit J Translation, ribosomal structure and biogenesis ; IPR013906 [Eukaryotic translation initiation factor 3 subunit J] -- -- Q52JJ6 Aminopeptidase Enpep 1708.6 1666.6 1932.6 1786 1697.6 1860.6 0.993188877661764 0.904591444405213 -0.00985998946610711 Nonsignificant None 2 Molecular Function:metallopeptidase activity (GO:0008237),Molecular Function:zinc ion binding (GO:0008270) glutamyl aminopeptidase 3.4.11.7 ko04614 Renin-angiotensin system Puromycin-sensitive aminopeptidase and related aminopeptidases EO Amino acid transport and metabolism ; Posttranslational modification, protein turnover, chaperones ; IPR014782 [Peptidase M1, membrane alanine aminopeptidase, N-terminal] ; IPR024571[ERAP1-like C-terminal domain] -- -- Q6PFD9 Nuclear pore complex protein Nup98-Nup96 Nup98 3446.9 3398.2 3352.5 3227.9 3188.6 3276.5 1.05205818632002 0.0107164199160325 0.07321449816056 Nonsignificant None 2 Cellular Component:nuclear pore (GO:0005643),Biological Process:transport (GO:0006810) nuclear pore complex protein Nup98-Nup96 -- ko03013 RNA transport ko05164 Influenza A Nuclear pore complex, Nup98 component (sc Nup145/Nup100/Nup116) YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; IPR007230 [Peptidase S59, nucleoporin] ; IPR021967[Nuclear protein 96] -- -- Q62446 Peptidyl-prolyl cis-trans isomerase FKBP3 Fkbp3 5310.7 5617.8 4346.3 4199.4 4160.5 4026.8 1.23316137470028 0.125984354591885 0.302361606914966 Nonsignificant None -- -- FK506-binding protein 3 5.2.1.8 -- FKBP-type peptidyl-prolyl cis-trans isomerase O Posttranslational modification, protein turnover, chaperones ; IPR001179 [FKBP-type peptidyl-prolyl cis-trans isomerase domain] -- -- Q542S9 Syntrophin, basic 2 Sntb2 2527 2535.4 2202.7 2564.6 2441.5 2577.8 0.957963580743417 0.418061050904736 -0.0619572853555568 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Syntrophins (type beta) W Extracellular structures ; IPR001478 [PDZ domain] -- -- Q4VAG4 Ribosomal protein L22 Rpl22 5602.4 5695.4 4641.7 3873.9 3909.5 3979 1.35512310412841 0.0527280587983624 0.438423917002278 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L22e -- ko03010 Ribosome 60S ribosomal protein L22 J Translation, ribosomal structure and biogenesis ; IPR002671 [Ribosomal protein L22e] -- -- Q9D7X3 Dual specificity protein phosphatase 3 Dusp3 1497.2 1585.7 1684.2 1797.6 1793.1 1865.3 0.873735337243402 0.0175024287816972 -0.194731755058777 Nonsignificant None 2 Biological Process:protein dephosphorylation (GO:0006470),Molecular Function:protein tyrosine/serine/threonine phosphatase activity (GO:0008138) -- -- ko04010 MAPK signaling pathway Dual specificity phosphatase V Defense mechanisms ; IPR000340 [Dual specificity phosphatase, catalytic domain] -- -- Q8CCF0 U4/U6 small nuclear ribonucleoprotein Prp31 Prpf31 2223.2 2149.9 2081.8 1857 1894.3 1965.2 1.12916994664567 0.00890572034897697 0.175262636448742 Nonsignificant None -- -- U4/U6 small nuclear ribonucleoprotein PRP31 -- ko03040 Spliceosome mRNA splicing factor PRP31 A RNA processing and modification ; IPR002687 [Nop domain] ; IPR019175[Prp31 C-terminal] -- -- P19783 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Cox4i1 5399.6 5299.5 4107.8 4123.1 4064.4 4257.8 1.18975838268262 0.196278310254106 0.250668619333067 Nonsignificant None 1 Molecular Function:cytochrome-c oxidase activity (GO:0004129) cytochrome c oxidase subunit 4 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04260 Cardiac muscle contraction ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Cytochrome c oxidase, subunit IV/COX5b C Energy production and conversion ; IPR004203 [Cytochrome c oxidase subunit IV family] -- -- Q9DBX3 Sushi domain-containing protein 2 Susd2 2199.3 2319.5 2897.6 2896 2700.8 2840.8 0.878970323314687 0.201985280007861 -0.186113638425958 Nonsignificant None 3 Molecular Function:scavenger receptor activity (GO:0005044),Biological Process:immune response (GO:0006955),Molecular Function:polysaccharide binding (GO:0030247) -- -- -- Mucin/alpha-tectorin W Extracellular structures ; IPR000436 [Sushi/SCR/CCP domain] ; IPR001212[Somatomedin B domain] ; IPR001846[von Willebrand factor, type D domain] ; IPR005533[AMOP domain] -- -- Q3TD78 NIPSNAP domain-containing protein Nipsnap2 1897.8 1875.5 2553.3 2818 2630.3 2933.8 0.754775056370122 0.0457540911457175 -0.405881349010145 Nonsignificant None -- -- -- -- -- NIPSNAP1 protein S Function unknown ; IPR012577 [NIPSNAP] -- -- E9QNL5 Sulfotransferase Sult1a1 1619.5 1540.1 1657.6 3267 3083.7 3385.8 0.494756842807991 0.0000645796644586435 -1.01520843406857 Significant down 1 Molecular Function:sulfotransferase activity (GO:0008146) aryl sulfotransferase 2.8.2.1 ko05204 Chemical carcinogenesis Sulfotransferase R General function prediction only ; IPR000863 [Sulfotransferase domain] -- -- P63028 Translationally-controlled tumor protein Tpt1 7998.1 8338.3 6896.9 5120.3 5448.5 5412.4 1.45378945260681 0.00567279640150414 0.539818343758943 Nonsignificant None -- -- -- -- -- Microtubule-binding protein (translationally controlled tumor protein) DZ Cell cycle control, cell division, chromosome partitioning ; Cytoskeleton ; IPR018105 [Translationally controlled tumour protein] -- -- Q6NVF9 Cleavage and polyadenylation specificity factor subunit 6 Cpsf6 1617.1 1638.6 1628.2 1629 1642.8 1626 0.997161991098044 0.59707258412027 -0.0041002023301389 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) cleavage and polyadenylation specificity factor subunit 6/7 -- ko03015 mRNA surveillance pathway mRNA cleavage factor I subunit/CPSF subunit A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- P05480 Proto-oncogene tyrosine-protein kinase Src Src 784.4 764.8 730.6 902.4 842 908.8 0.859264284637419 0.00927759433664881 -0.218826164345345 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein binding (GO:0005515),Biological Process:protein phosphorylation (GO:0006468) tyrosine-protein kinase Src 2.7.10.2 ko01521 EGFR tyrosine kinase inhibitor resistance ko01522 Endocrine resistance ko04012 ErbB signaling pathway ko04015 Rap1 signaling pathway ko04062 Chemokine signaling pathway ko04137 Mitophagy - animal ko04144 Endocytosis ko04360 Axon guidance ko04370 VEGF signaling pathway ko04510 Focal adhesion ko04520 Adherens junction ko04530 Tight junction ko04540 Gap junction ko04611 Platelet activation ko04727 GABAergic synapse ko04750 Inflammatory mediator regulation of TRP channels ko04810 Regulation of actin cytoskeleton ko04912 GnRH signaling pathway ko04915 Estrogen signaling pathway ko04917 Prolactin signaling pathway ko04919 Thyroid hormone signaling pathway ko04921 Oxytocin signaling pathway ko04926 Relaxin signaling pathway ko05100 Bacterial invasion of epithelial cells ko05152 Tuberculosis ko05161 Hepatitis B ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05203 Viral carcinogenesis ko05205 Proteoglycans in cancer ko05219 Bladder cancer ko05418 Fluid shear stress and atherosclerosis Tyrosine kinases T Signal transduction mechanisms ; IPR000980 [SH2 domain] ; IPR001245[Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR001452[SH3 domain] -- -- Q99JX7 Nuclear RNA export factor 1 Nxf1 1201.4 1234.3 972.4 972.3 991.2 968.1 1.16253922772547 0.192787988959417 0.217279398104688 Nonsignificant None 7 Molecular Function:RNA binding (GO:0003723),Cellular Component:intracellular (GO:0005622),Cellular Component:nucleus (GO:0005634),Cellular Component:cytoplasm (GO:0005737),Biological Process:mRNA export from nucleus (GO:0006406),Biological Process:transport (GO:0006810),Biological Process:mRNA transport (GO:0051028) nuclear RNA export factor -- ko03008 Ribosome biogenesis in eukaryotes ko03013 RNA transport ko03015 mRNA surveillance pathway ko05164 Influenza A ko05168 Herpes simplex infection mRNA export factor TAP/MEX67 A RNA processing and modification ; IPR002075 [Nuclear transport factor 2] ; IPR005637[TAP C-terminal (TAP-C) domain] ; IPR015245[Nuclear RNA export factor Tap, RNA-binding domain] -- -- Q543Q4 Ras-related protein Rab-3 Rab3d 770 711.9 731.9 826.1 860.6 837.7 0.876960861987007 0.00642015244609892 -0.189415637026033 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-3D -- ko04972 Pancreatic secretion GTPase Rab3, small G protein superfamily U Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- A0A6I8MX07 Golgin subfamily A member 2 Golga2 1707 1662.5 1880.7 1792.5 1794 1806.2 0.973575388951731 0.549750524098123 -0.0386353963160689 Nonsignificant None 1 Cellular Component:Golgi apparatus (GO:0005794) golgin subfamily A member 2 -- -- Uncharacterized conserved protein S Function unknown ; IPR024858 [Golgin subfamily A] -- -- Q62086 Serum paraoxonase/arylesterase 2 Pon2 2105.1 2178.9 2567.3 2465.3 2367.6 2407.7 0.946233737535564 0.424718874614308 -0.0797314944821578 Nonsignificant None 1 Molecular Function:arylesterase activity (GO:0004064) -- -- -- -- -- IPR002640 [Arylesterase] -- -- Q8C0C7 Phenylalanine--tRNA ligase alpha subunit Farsa 3078.8 3145.1 3492.7 3456.1 3580.3 3327.2 0.937569956385812 0.218007258893702 -0.0930017542949157 Nonsignificant None 5 Molecular Function:tRNA binding (GO:0000049),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Cellular Component:cytoplasm (GO:0005737),Biological Process:tRNA aminoacylation (GO:0043039) phenylalanyl-tRNA synthetase alpha chain 6.1.1.20 ko00970 Aminoacyl-tRNA biosynthesis Phenylalanyl-tRNA synthetase, beta subunit J Translation, ribosomal structure and biogenesis ; IPR002319 [Phenylalanyl-tRNA synthetase] -- -- Q9CRB9 MICOS complex subunit Mic19 Chchd3 4163.1 3954.1 4049 4993.5 4719.3 4935.7 0.830542376352528 0.00130440935258742 -0.267874314906868 Nonsignificant None -- -- coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial -- -- Head-elevated expression protein K Transcription ; IPR007964 [Protein of unknown function DUF737] -- -- P97379 Ras GTPase-activating protein-binding protein 2 G3bp2 3438.6 3216.8 2728.9 2519.5 2562.6 2658.3 1.21237920520903 0.0622765701607816 0.277841012266975 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Cellular Component:intracellular (GO:0005622),Biological Process:transport (GO:0006810) -- -- -- RasGAP SH3 binding protein rasputin, contains NTF2 and RRM domains T Signal transduction mechanisms ; IPR000504 [RNA recognition motif domain] ; IPR002075[Nuclear transport factor 2] -- -- Q8C2M8 Interferon gamma induced GTPase Igtp 1762.4 2063.7 1963.4 1620.3 1828.8 1667.7 1.13146888680425 0.108239097866232 0.178196913840019 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Cellular Component:membrane (GO:0016020) interferon gamma induced GTPase -- ko05145 Toxoplasmosis -- -- -- IPR007743 [Immunity-related GTPases-like] -- -- P57716 Nicastrin Ncstn 1608 1550.2 1671.3 1472.1 1669.8 1562.1 1.02667942176871 0.566215259182371 0.0379857738433239 Nonsignificant None 2 Cellular Component:integral component of membrane (GO:0016021),Biological Process:protein processing (GO:0016485) nicastrin -- ko04330 Notch signaling pathway ko05010 Alzheimer's disease Transmembrane glycoprotein nicastrin TO Signal transduction mechanisms ; Posttranslational modification, protein turnover, chaperones ; IPR008710 [Nicastrin] -- -- Q8K0C4 Lanosterol 14-alpha demethylase Cyp51a1 1820 1723.8 1895.3 1981.9 2190.7 2083.4 0.869421355498721 0.0251857939649153 -0.201872562080528 Nonsignificant None 3 Molecular Function:iron ion binding (GO:0005506),Molecular Function:heme binding (GO:0020037),Biological Process:oxidation-reduction process (GO:0055114) sterol 14-demethylase 1.14.13.70 ko00100 Steroid biosynthesis ko01100 Metabolic pathways Cytochrome P450 Q Secondary metabolites biosynthesis, transport and catabolism ; IPR001128 [Cytochrome P450] -- -- Q3U5M2 Pre-mRNA-splicing factor SPF27 Bcas2 1177.9 1287.3 1326 1306.9 1277.2 1274.1 0.98263438909336 0.649685491234102 -0.0252733651549425 Nonsignificant None 1 Biological Process:mRNA processing (GO:0006397) pre-mRNA-splicing factor SPF27 -- ko03040 Spliceosome Spliceosome-associated coiled-coil protein S Function unknown ; IPR008409 [Pre-mRNA-splicing factor SPF27] -- -- O08547 Vesicle-trafficking protein SEC22b Sec22b 2165.5 2178.3 2391.5 2412.4 2439.7 2281.8 0.944125933921137 0.20564142386172 -0.0829487860144121 Nonsignificant None 2 Cellular Component:integral component of membrane (GO:0016021),Biological Process:vesicle-mediated transport (GO:0016192) vesicle transport protein SEC22 -- ko04130 SNARE interactions in vesicular transport ko04145 Phagosome ko05134 Legionellosis Synaptobrevin/VAMP-like protein SEC22 U Intracellular trafficking, secretion, and vesicular transport ; IPR001388 [Synaptobrevin] ; IPR010908[Longin domain] -- -- Q3U781 RRM domain-containing protein Srsf3 2651 2626.9 2487.6 2297.2 2182.6 2233.4 1.15675087886552 0.00447212495642789 0.210078195021163 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) splicing factor, arginine/serine-rich 3 -- ko03040 Spliceosome ko05168 Herpes simplex infection Alternative splicing factor SRp20/9G8 (RRM superfamily) A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- G5E895 Aldo-keto reductase family 1, member B10 (aldose reductase) Akr1b10 861.5 864.3 933.6 1028.4 993.8 1054.6 0.864339573582943 0.00911892313516573 -0.210329878705034 Nonsignificant None -- -- aldehyde reductase 1.1.1.21 ko00040 Pentose and glucuronate interconversions ko00051 Fructose and mannose metabolism ko00052 Galactose metabolism ko00561 Glycerolipid metabolism ko00790 Folate biosynthesis ko01100 Metabolic pathways Aldo/keto reductase family proteins R General function prediction only ; IPR023210 [NADP-dependent oxidoreductase domain] -- -- Q9CS42 Ribose-phosphate pyrophosphokinase 2 Prps2 692.2 663.6 527 594.1 630 643.3 1.00824676020135 0.927566363239019 0.0118487699402124 Nonsignificant None 3 Molecular Function:magnesium ion binding (GO:0000287),Molecular Function:ribose phosphate diphosphokinase activity (GO:0004749),Biological Process:nucleotide biosynthetic process (GO:0009165) ribose-phosphate pyrophosphokinase 2.7.6.1 ko00030 Pentose phosphate pathway ko00230 Purine metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids Ribose-phosphate pyrophosphokinase FE Nucleotide transport and metabolism ; Amino acid transport and metabolism ; IPR005946 [Ribose-phosphate diphosphokinase] ; IPR029099[Ribose-phosphate pyrophosphokinase, N-terminal domain] -- -- Q91WL0 Epidermal growth factor receptor kinase substrate 8-like protein 3 Eps8l3 1238.1 1295.7 1543 1774.8 1675 1588.7 0.80912970129999 0.0410810656658356 -0.305557113586717 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) epidermal growth factor receptor kinase substrate 8 -- -- Epidermal growth factor receptor kinase substrate T Signal transduction mechanisms ; IPR001452 [SH3 domain] ; IPR013625[Tensin/EPS8 phosphotyrosine-binding domain] -- -- Q3UM45 Protein phosphatase 1 regulatory subunit 7 Ppp1r7 2182.7 2070.4 2156.5 2260.6 2307.2 2275.3 0.936651517587058 0.016849781611063 -0.094415703739829 Nonsignificant None -- -- protein phosphatase 1 regulatory subunit 7 -- -- Protein phosphatase 1, regulatory subunit, and related proteins T Signal transduction mechanisms ; -- -- -- Q8R3G9 Tetraspanin-8 Tspan8 2962.4 2603.9 3935.8 4043.1 3916.3 3669.6 0.817103792243529 0.16098409694546 -0.291408747184389 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) tetraspanin-8 -- -- Tetraspanin family integral membrane protein R General function prediction only ; IPR018499 [Tetraspanin/Peripherin] -- -- Q9D967 Magnesium-dependent phosphatase 1 Mdp1 1534.7 1459.3 1801 1930.7 1967.5 1953.8 0.819377990430622 0.0751900244518155 -0.287398954232994 Nonsignificant None 1 Molecular Function:phosphatase activity (GO:0016791) -- -- -- Magnesium-dependent phosphatase R General function prediction only ; IPR010036 [Magnesium-dependent phosphatase-1, eukaryotic/archaeal type] -- -- Q9CZR8 Elongation factor Ts, mitochondrial Tsfm 1298.5 1274.1 1510 1552.7 1617.4 1663.4 0.844646736319437 0.03723781394556 -0.243580017780329 Nonsignificant None 3 Molecular Function:translation elongation factor activity (GO:0003746),Cellular Component:intracellular (GO:0005622),Biological Process:translational elongation (GO:0006414) elongation factor Ts -- -- Mitochondrial translation elongation factor EF-Tsmt, catalyzes nucleotide exchange on EF-Tumt J Translation, ribosomal structure and biogenesis ; IPR014039 [Translation elongation factor EFTs/EF1B, dimerisation] -- -- P97499 Telomerase protein component 1 Tep1 1829.1 1706.5 1746.6 1821.6 1842.8 1830.3 0.961326369046536 0.125128284597241 -0.0569017876456314 Nonsignificant None 2 Molecular Function:RNA binding (GO:0003723),Molecular Function:protein binding (GO:0005515) telomerase protein component 1 -- -- WD40 repeat-containing protein R General function prediction only ; IPR001680 [WD40 repeat] ; IPR008850[TEP1, N-terminal] ; IPR008858[TROVE domain] ; IPR025139[Domain of unknown function DUF4062] -- -- Q3UXI9 DZF domain-containing protein Ilf2 3914.6 3925.4 2885.5 2458 2482 2671.5 1.40911778230309 0.0418056043830395 0.494792205574279 Nonsignificant None -- -- interleukin enhancer-binding factor 2 -- -- Transcription factor NFAT, subunit NF45 K Transcription ; IPR006561 [DZF domain] -- -- Q3V397 Uncharacterized protein Pigs 1582.9 1516.3 1278.7 1380.1 1495 1411.4 1.02132275749446 0.772503902568239 0.0304388574529801 Nonsignificant None 2 Biological Process:attachment of GPI anchor to protein (GO:0016255),Cellular Component:GPI-anchor transamidase complex (GO:0042765) phosphatidylinositol glycan, class S -- ko00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis ko01100 Metabolic pathways GPI transamidase complex, GPI17/PIG-S component, involved in glycosylphosphatidylinositol anchor biosynthesis MO Cell wall/membrane/envelope biogenesis ; Posttranslational modification, protein turnover, chaperones ; IPR019540 [Phosphatidylinositol-glycan biosynthesis class S protein] -- -- Q8K183 Pyridoxal kinase Pdxk 1185 1247.6 1245.5 1398.2 1308.8 1499.4 0.874405667554203 0.0400593130167086 -0.193625342864457 Nonsignificant None -- -- pyridoxine kinase 2.7.1.35 ko00750 Vitamin B6 metabolism ko01100 Metabolic pathways Pyridoxal/pyridoxine/pyridoxamine kinase H Coenzyme transport and metabolism ; IPR013749 [Pyridoxamine kinase/Phosphomethylpyrimidine kinase] -- -- P11930 Acyl-coenzyme A diphosphatase NUDT19 Nudt19 1015.3 943.8 768.5 797.6 741.5 825.5 1.15351433646283 0.192855726907133 0.206035934680014 Nonsignificant None -- -- nucleoside diphosphate-linked moiety X motif 19, mitochondrial 3.6.1.- ko04146 Peroxisome Predicted hydrolase RP2 (NUDIX/MutT superfamily) S Function unknown ; -- -- -- Q3UIX8 Uncharacterized protein Ctbp2 856.3 795.4 851.2 889.4 841.6 915 0.945918367346939 0.175778346358803 -0.08021241037704 Nonsignificant None 3 Biological Process:metabolic process (GO:0008152),Molecular Function:NAD binding (GO:0051287),Biological Process:oxidation-reduction process (GO:0055114) C-terminal binding protein -- ko04310 Wnt signaling pathway ko04330 Notch signaling pathway ko05200 Pathways in cancer ko05220 Chronic myeloid leukemia Transcription factor CtBP K Transcription ; IPR006139 [D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain] ; IPR006140[D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain] -- -- Q9R0Q7 Prostaglandin E synthase 3 Ptges3 3032.4 3254.7 2598.1 2664.8 2692.3 2618.5 1.11404784593009 0.255563943981951 0.155811194620279 Nonsignificant None -- -- cytosolic prostaglandin-E synthase 5.3.99.3 ko00590 Arachidonic acid metabolism ko01100 Metabolic pathways HSP90 co-chaperone p23 O Posttranslational modification, protein turnover, chaperones ; IPR007052 [CS domain] -- -- Q9JHU9 Inositol-3-phosphate synthase 1 Isyna1 4428.8 4444.9 3843 3472.6 4127.7 3586 1.13681020534046 0.145751161435077 0.18499141107263 Nonsignificant None 3 Molecular Function:inositol-3-phosphate synthase activity (GO:0004512),Biological Process:inositol biosynthetic process (GO:0006021),Biological Process:phospholipid biosynthetic process (GO:0008654) myo-inositol-1-phosphate synthase 5.5.1.4 ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways Myo-inositol-1-phosphate synthase I Lipid transport and metabolism ; IPR002587 [Myo-inositol-1-phosphate synthase] ; IPR013021[Myo-inositol-1-phosphate synthase, GAPDH-like] -- -- Q9DCC4 Pyrroline-5-carboxylate reductase 3 Pycr3 2836.6 2950.2 3681.2 3834.7 3778.1 3568.2 0.846793667829353 0.108080196510045 -0.239917613715391 Nonsignificant None -- -- pyrroline-5-carboxylate reductase 1.5.1.2 ko00330 Arginine and proline metabolism ko01100 Metabolic pathways ko01230 Biosynthesis of amino acids Pyrroline-5-carboxylate reductase E Amino acid transport and metabolism ; IPR028939 [Pyrroline-5-carboxylate reductase, catalytic, N-terminal] ; IPR029036[Pyrroline-5-carboxylate reductase, dimerisation domain] -- -- Q3U3F6 RRM domain-containing protein Raly 4011.5 3923.3 3765.8 3371 3439.2 3462.4 1.13901057181239 0.00346574306006838 0.18778113759083 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) heterogeneous nuclear ribonucleoprotein C-like 2 -- -- FOG: RRM domain R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- Q8C2T3 Uncharacterized protein (Fragment) Ptma 969.7 994.2 749.5 928.5 985.3 897.6 0.965141922174006 0.710486608807526 -0.051186991509935 Nonsignificant None -- -- prothymosin alpha -- ko05169 Epstein-Barr virus infection -- -- -- IPR004931 [Prothymosin/parathymosin] -- -- B2RS76 carboxypeptidase B1 (Tissue) Cpb1 1195 948.3 921.8 913.4 1895.8 919 0.822139370205461 0.548752272726486 -0.282545112585537 Nonsignificant None 4 Molecular Function:carboxypeptidase activity (GO:0004180),Molecular Function:metallocarboxypeptidase activity (GO:0004181),Biological Process:proteolysis (GO:0006508),Molecular Function:zinc ion binding (GO:0008270) carboxypeptidase B 3.4.17.2 ko04972 Pancreatic secretion ko04974 Protein digestion and absorption Zinc carboxypeptidase S Function unknown ; IPR000834 [Peptidase M14, carboxypeptidase A] ; IPR003146[Carboxypeptidase, activation peptide] -- -- Q9DCS3 Enoyl-[acyl-carrier-protein] reductase, mitochondrial Mecr 1738.6 1587.9 1474.1 2194.8 2376.6 2507.4 0.678165790812002 0.00306256530788439 -0.560290083556518 Nonsignificant None 1 Biological Process:oxidation-reduction process (GO:0055114) mitochondrial trans-2-enoyl-CoA reductase 1.3.1.38 ko00062 Fatty acid elongation ko01100 Metabolic pathways ko01212 Fatty acid metabolism Zn2+-binding dehydrogenase (nuclear receptor binding factor-1) KC Transcription ; Energy production and conversion ; IPR013149 [Alcohol dehydrogenase, C-terminal] ; IPR013154[Alcohol dehydrogenase, N-terminal] -- -- Q3TDY6 Tripeptidyl-peptidase 1 Tpp1 1403.2 1421.6 1434.5 1569.8 1553.2 1583 0.905078623034424 0.000286477787839082 -0.143884972155607 Nonsignificant None 1 Molecular Function:serine-type peptidase activity (GO:0008236) tripeptidyl-peptidase I 3.4.14.9 ko04142 Lysosome -- -- -- IPR015366 [Peptidase S53, activation domain] -- -- P04117 Fatty acid-binding protein, adipocyte Fabp4 4267.5 4511.5 4587.3 4199 4326.1 4727.1 1.00860989118788 0.848041590169685 0.0123682786308852 Nonsignificant None -- -- fatty acid-binding protein 4, adipocyte -- ko03320 PPAR signaling pathway ko04923 Regulation of lipolysis in adipocytes Fatty acid-binding protein FABP I Lipid transport and metabolism ; IPR000566 [Lipocalin/cytosolic fatty-acid binding domain] -- -- Q3TBM1 Alpha-mannosidase Man2b1 1886.2 1912.7 1980.2 1891.6 1967.7 1878.3 1.00723298940323 0.743715727910121 0.0103974408195221 Nonsignificant None 5 Molecular Function:alpha-mannosidase activity (GO:0004559),Biological Process:carbohydrate metabolic process (GO:0005975),Biological Process:mannose metabolic process (GO:0006013),Molecular Function:zinc ion binding (GO:0008270),Molecular Function:mannosidase activity (GO:0015923) lysosomal alpha-mannosidase 3.2.1.24 ko00511 Other glycan degradation ko04142 Lysosome Glycosyl hydrolase, family 38 - alpha-mannosidase G Carbohydrate transport and metabolism ; IPR000602 [Glycoside hydrolase family 38, N-terminal domain] ; IPR011682[Glycosyl hydrolase family 38, C-terminal] ; IPR015341[Glycoside hydrolase family 38, central domain] -- -- Q3TJS1 Beta-1,4-galactosyltransferase B4galt1 1135.8 1148.2 1041.6 1174.1 1338.6 1039.2 0.936287620710042 0.462279880134673 -0.0949763116269057 Nonsignificant None -- -- -- -- ko00052 Galactose metabolism ko00510 N-Glycan biosynthesis ko00514 Other types of O-glycan biosynthesis ko00515 Mannose type O-glycan biosynthesis ko00533 Glycosaminoglycan biosynthesis - keratan sulfate ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series ko01100 Metabolic pathways UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase G Carbohydrate transport and metabolism ; IPR027791 [Galactosyltransferase, C-terminal] ; IPR027995[Galactosyltransferase, N-terminal] -- -- Q80W54 CAAX prenyl protease 1 homolog Zmpste24 1978.1 1976.5 2013.1 1900.3 1937.9 1932.7 1.03410213311615 0.0173426344380832 0.0483786804919012 Nonsignificant None 2 Molecular Function:metalloendopeptidase activity (GO:0004222),Biological Process:proteolysis (GO:0006508) STE24 endopeptidase 3.4.24.84 ko00900 Terpenoid backbone biosynthesis Metalloprotease R General function prediction only ; IPR001915 [Peptidase M48] ; IPR032456[CAAX prenyl protease 1, N-terminal] -- -- Q91WG0 Acylcarnitine hydrolase Ces2c 855.5 870.2 1315 1099.5 1040.9 1209.3 0.907752933098486 0.551583673990694 -0.139628408270247 Nonsignificant None -- -- -- -- ko00983 Drug metabolism - other enzymes Carboxylesterase and related proteins R General function prediction only ; IPR002018 [Carboxylesterase, type B] -- -- P27048 Small nuclear ribonucleoprotein-associated protein B Snrpb 4122.6 4463.3 3573.7 3576.6 3443.8 3486.2 1.15732967848781 0.164664491617043 0.210799891039484 Nonsignificant None -- -- small nuclear ribonucleoprotein B and B' -- ko03040 Spliceosome ko05322 Systemic lupus erythematosus U1 snRNP component K Transcription ; IPR001163 [LSM domain, eukaryotic/archaea-type] -- -- A0A0N4SUN3 Dysferlin Dysf 1009.4 1089.8 1110.3 1223.4 1233.4 1135.1 0.893538238815112 0.0438410023758483 -0.162398624413563 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:integral component of membrane (GO:0016021) dysferlin -- -- Membrane-associated protein FER-1 and related ferlins, contain multiple C2 domains M Cell wall/membrane/envelope biogenesis ; IPR000008 [C2 domain] ; IPR012560[Ferlin A-domain] ; IPR012561[Ferlin B-domain] ; IPR012968[FerIin domain] ; IPR032362[Ferlin, C-terminal domain] -- -- O88512 AP-1 complex subunit gamma-like 2 Ap1g2 1036 983.9 989.1 987.7 1043.7 1009.7 0.989444608858637 0.669063640336417 -0.0153091503854148 Nonsignificant None 4 Biological Process:intracellular protein transport (GO:0006886),Biological Process:vesicle-mediated transport (GO:0016192),Cellular Component:membrane coat (GO:0030117),Cellular Component:clathrin adaptor complex (GO:0030131) AP-1 complex subunit gamma-1 -- ko04142 Lysosome Vesicle coat complex AP-1, gamma subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR002553 [Clathrin/coatomer adaptor, adaptin-like, N-terminal] ; IPR008152[Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain] -- -- Q6P2K2 Acyl-CoA thioesterase 2 Acot2 162.5 149.7 213.5 196.6 201.1 228.2 0.839910528838473 0.200981909792715 -0.251692441372003 Nonsignificant None -- -- acyl-coenzyme A thioesterase 1/2/4 3.1.2.2 ko00062 Fatty acid elongation ko01040 Biosynthesis of unsaturated fatty acids ko01100 Metabolic pathways -- -- -- IPR006862 [Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase] ; IPR014940[BAAT/Acyl-CoA thioester hydrolase C-terminal] -- -- P06795 ATP-dependent translocase ABCB1 Abcb1b 26.6 21.2 28.6 31.3 25 25.1 0.938574938574939 0.612385621756695 -0.0914561562304982 Nonsignificant None 5 Molecular Function:ATP binding (GO:0005524),Biological Process:transport (GO:0006810),Cellular Component:integral component of membrane (GO:0016021),Molecular Function:ATPase activity (GO:0016887),Biological Process:transmembrane transport (GO:0055085) ATP-binding cassette, subfamily B (MDR/TAP), member 1 3.6.3.44 ko02010 ABC transporters ko04976 Bile secretion ko05206 MicroRNAs in cancer ko05226 Gastric cancer Multidrug/pheromone exporter, ABC superfamily Q Secondary metabolites biosynthesis, transport and catabolism ; IPR003439 [ABC transporter-like] ; IPR011527[ABC transporter type 1, transmembrane domain] -- -- Q570Z8 MKIAA4114 protein (Fragment) Picalm 2330.1 2300.5 2619.8 2334 2395.5 2342.8 1.02518275525642 0.597475128974897 0.0358811161696695 Nonsignificant None 1 Molecular Function:phospholipid binding (GO:0005543) phosphatidylinositol-binding clathrin assembly protein -- -- Clathrin assembly protein AP180 and related proteins, contain ENTH domain TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR011417 [AP180 N-terminal homology (ANTH) domain] -- -- Q9CR61 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 Ndufb7 1828.8 1636.4 1695 1930.3 1905.7 1867.9 0.904679254545136 0.038677853514077 -0.144521705892726 Nonsignificant None 3 Molecular Function:NADH dehydrogenase activity (GO:0003954),Cellular Component:mitochondrion (GO:0005739),Molecular Function:NADH dehydrogenase (ubiquinone) activity (GO:0008137) NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 7 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease NADH:ubiquinone oxidoreductase, NDUFB7/B18 subunit C Energy production and conversion ; IPR008698 [NADH:ubiquinone oxidoreductase, B18 subunit] -- -- P32883 GTPase KRas Kras 763.6 688.3 755 860.9 925.9 877.6 0.828291547815643 0.00771735231556052 -0.271789427943316 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) GTPase NRas -- ko01521 EGFR tyrosine kinase inhibitor resistance ko01522 Endocrine resistance ko04010 MAPK signaling pathway ko04012 ErbB signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04062 Chemokine signaling pathway ko04068 FoxO signaling pathway ko04071 Sphingolipid signaling pathway ko04072 Phospholipase D signaling pathway ko04137 Mitophagy - animal ko04140 Autophagy - animal ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04210 Apoptosis ko04211 Longevity regulating pathway ko04213 Longevity regulating pathway - multiple species ko04218 Cellular senescence ko04360 Axon guidance ko04370 VEGF signaling pathway ko04371 Apelin signaling pathway ko04540 Gap junction ko04550 Signaling pathways regulating pluripotency of stem cells ko04650 Natural killer cell mediated cytotoxicity ko04660 T cell receptor signaling pathway ko04662 B cell receptor signaling pathway ko04664 Fc epsilon RI signaling pathway ko04720 Long-term potentiation ko04722 Neurotrophin signaling pathway ko04725 Cholinergic synapse ko04726 Serotonergic synapse ko04730 Long-term depression ko04810 Regulation of actin cytoskeleton ko04910 Insulin signaling pathway ko04912 GnRH signaling pathway ko04915 Estrogen signaling pathway ko04916 Melanogenesis ko04917 Prolactin signaling pathway ko04919 Thyroid hormone signaling pathway ko04921 Oxytocin signaling pathway ko04926 Relaxin signaling pathway ko04933 AGE-RAGE signaling pathway in diabetic complications ko05034 Alcoholism ko05160 Hepatitis C ko05161 Hepatitis B ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05205 Proteoglycans in cancer ko05206 MicroRNAs in cancer ko05211 Renal cell carcinoma ko05213 Endometrial cancer ko05214 Glioma ko05215 Prostate cancer ko05216 Thyroid cancer ko05218 Melanoma ko05219 Bladder cancer ko05220 Chronic myeloid leukemia ko05221 Acute myeloid leukemia ko05223 Non-small cell lung cancer ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer ko05230 Central carbon metabolism in cancer ko05231 Choline metabolism in cancer Ras-related GTPase R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- Q9JM76 Actin-related protein 2/3 complex subunit 3 Arpc3 5183 5195.1 4384.2 4104.1 4063 4318.1 1.18238394258802 0.0533396520920137 0.24169858215258 Nonsignificant None 4 Cellular Component:cytoskeleton (GO:0005856),Cellular Component:Arp2/3 protein complex (GO:0005885),Biological Process:regulation of actin filament polymerization (GO:0030833),Biological Process:Arp2/3 complex-mediated actin nucleation (GO:0034314) actin related protein 2/3 complex, subunit 3 -- ko04144 Endocytosis ko04666 Fc gamma R-mediated phagocytosis ko04810 Regulation of actin cytoskeleton ko05100 Bacterial invasion of epithelial cells ko05132 Salmonella infection Actin-related protein Arp2/3 complex, subunit ARPC3 Z Cytoskeleton ; IPR007204 [Actin-related protein 2/3 complex subunit 3] -- -- B1AWB9 Collagen, type V, alpha 1 Col5a1 1683.1 1663.1 1751.3 1923.1 1782.4 1796.7 0.926447602777071 0.0606453711022046 -0.110218711026946 Nonsignificant None 1 Molecular Function:extracellular matrix structural constituent (GO:0005201) collagen, type V/XI/XXIV/XXVII, alpha -- ko04974 Protein digestion and absorption Collagens (type IV and type XIII), and related proteins W Extracellular structures ; IPR000885 [Fibrillar collagen, C-terminal] ; IPR001791[Laminin G domain] ; IPR008160[Collagen triple helix repeat] -- -- A0A1B0GRA5 Stromal interaction molecule 1 Stim1 2579.7 2344.8 2282.4 2987 3160.1 3110.7 0.778467886538919 0.00278460151009992 -0.361290568603781 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) stromal interaction molecule 1 -- ko04020 Calcium signaling pathway ko04611 Platelet activation Cell surface glycoprotein STIM, contains SAM domain R General function prediction only ; IPR001660 [Sterile alpha motif domain] ; IPR032393[Stromal interaction molecule, Orai1-activating region] -- -- Q7TMF3 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 Ndufa12 1505.6 1543.6 1772.4 2050.9 1951.9 2138.6 0.785097860422705 0.0114008585648232 -0.349055601459993 Nonsignificant None 3 Molecular Function:NADH dehydrogenase (ubiquinone) activity (GO:0008137),Molecular Function:electron carrier activity (GO:0009055),Cellular Component:membrane (GO:0016020) NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 12 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease NADH:ubiquinone oxidoreductase, B17.2 subunit C Energy production and conversion ; IPR007763 [NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12] -- -- Q61649 Alpha-globin mRNA (Fragment) 291.9 348.6 344.5 311.8 462.4 346.4 0.878993396394789 0.409061283927899 -0.186075767999089 Nonsignificant None 2 Molecular Function:oxygen binding (GO:0019825),Molecular Function:heme binding (GO:0020037) hemoglobin subunit alpha -- ko05143 African trypanosomiasis ko05144 Malaria Globins and related hemoproteins C Energy production and conversion ; IPR000971 [Globin] -- -- Q9CQD1 Ras-related protein Rab-5A Rab5a 1073.6 1040 1035.8 1120 1114.5 1060.8 0.955724820198464 0.095204105733916 -0.0653328089860464 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-5A -- ko04014 Ras signaling pathway ko04144 Endocytosis ko04145 Phagosome ko04962 Vasopressin-regulated water reabsorption ko05014 Amyotrophic lateral sclerosis (ALS) ko05146 Amoebiasis ko05152 Tuberculosis GTPase Rab5/YPT51 and related small G protein superfamily GTPases U Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- G3X9K3 Brefeldin A-inhibited guanine nucleotide-exchange protein 1 Arfgef1 1857.4 1597.7 1574.6 1580.8 1585 1571.1 1.06181257784627 0.394304259626955 0.0865291363171374 Nonsignificant None 2 Molecular Function:ARF guanyl-nucleotide exchange factor activity (GO:0005086),Biological Process:regulation of ARF protein signal transduction (GO:0032012) brefeldin A-inhibited guanine nucleotide-exchange protein -- ko04144 Endocytosis Guanine nucleotide exchange factor U Intracellular trafficking, secretion, and vesicular transport ; IPR000904 [Sec7 domain] ; IPR015403[Sec7, C-terminal] ; IPR032629[Mon2, dimerisation and cyclophilin-binding domain] ; IPR032691[Guanine nucleotide exchange factor, N-terminal] -- -- Q9JI67 Beta-1,3-galactosyltransferase 5 B3galt5 2433.4 2273.2 2144.2 2404.9 2249.8 2256.6 0.991246219958618 0.846645456023135 -0.0126846356670678 Nonsignificant None 3 Biological Process:protein glycosylation (GO:0006486),Molecular Function:galactosyltransferase activity (GO:0008378),Cellular Component:membrane (GO:0016020) beta-1,3-galactosyltransferase 5 2.4.1.- ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series ko00603 Glycosphingolipid biosynthesis - globo and isoglobo series ko01100 Metabolic pathways Galactosyltransferases G Carbohydrate transport and metabolism ; IPR002659 [Glycosyl transferase, family 31] -- -- Q61686 Chromobox protein homolog 5 Cbx5 2329.4 2405.8 2486.8 2169.4 2168.3 2129.6 1.11669475669909 0.00600733746961455 0.159234885751432 Nonsignificant None 1 Cellular Component:nucleus (GO:0005634) chromobox protein 5 -- -- Heterochromatin-associated protein HP1 and related CHROMO domain proteins B Chromatin structure and dynamics ; IPR008251 [Chromo shadow domain] ; IPR023780[Chromo domain] -- -- A0A0R4J039 Histidine-rich glycoprotein Hrg 2145.6 2364.4 1802.7 1649.6 1693.4 1656.2 1.2627420387262 0.114697956233567 0.336559945965162 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q3U1U4 Predicted gene, 49368 Gm49368 3028.7 3982.1 3325.1 2241 2386.7 2292.3 1.49362716763006 0.0531688000353883 0.57882007413946 Nonsignificant None -- -- integrin alpha M -- ko04015 Rap1 signaling pathway ko04145 Phagosome ko04514 Cell adhesion molecules (CAMs) ko04610 Complement and coagulation cascades ko04640 Hematopoietic cell lineage ko04670 Leukocyte transendothelial migration ko04810 Regulation of actin cytoskeleton ko05133 Pertussis ko05134 Legionellosis ko05140 Leishmaniasis ko05146 Amoebiasis ko05150 Staphylococcus aureus infection ko05152 Tuberculosis ko05202 Transcriptional misregulation in cancer ko05221 Acute myeloid leukemia Vitronectin receptor, alpha subunit W Extracellular structures ; IPR002035 [von Willebrand factor, type A] ; IPR013517[FG-GAP repeat] ; IPR013649[Integrin alpha-2] -- -- Q8BU33 2-hydroxyacyl-CoA lyase 2 Ilvbl 802.5 763.5 799.8 827.7 841.1 852.9 0.938176626878693 0.0232365956217076 -0.0920685359701585 Nonsignificant None 3 Molecular Function:magnesium ion binding (GO:0000287),Molecular Function:catalytic activity (GO:0003824),Molecular Function:thiamine pyrophosphate binding (GO:0030976) acetolactate synthase-like protein 2.2.1.- -- Thiamine pyrophosphate-requiring enzyme EH Amino acid transport and metabolism ; Coenzyme transport and metabolism ; IPR011766 [Thiamine pyrophosphate enzyme, C-terminal TPP-binding] ; IPR012000[Thiamine pyrophosphate enzyme, central domain] ; IPR012001[Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain] -- -- Q80YN3 Breast carcinoma-amplified sequence 1 homolog Bcas1 2217.5 2208.8 2590.1 2702.4 2876.5 2762.6 0.84114367919439 0.03119146819857 -0.249575840713013 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- P52196 Thiosulfate sulfurtransferase Tst 4262.7 3986.5 5475.8 6298.8 5526.5 6534.7 0.747549019607843 0.0482280537859673 -0.419759909521247 Nonsignificant None -- -- -- -- ko00270 Cysteine and methionine metabolism ko00920 Sulfur metabolism ko01100 Metabolic pathways ko04122 Sulfur relay system Mercaptopyruvate sulfurtransferase/thiosulfate sulfurtransferase V Defense mechanisms ; IPR001763 [Rhodanese-like domain] -- -- Q543X6 Protein kinase domain-containing protein Map2k4 1637.3 1581 1461.1 1542.5 1534.8 1553.5 1.01049494687743 0.785254300854126 0.0150621073355589 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) mitogen-activated protein kinase kinase 4 2.7.12.2 ko04010 MAPK signaling pathway ko04012 ErbB signaling pathway ko04620 Toll-like receptor signaling pathway ko04664 Fc epsilon RI signaling pathway ko04668 TNF signaling pathway ko04912 GnRH signaling pathway ko04926 Relaxin signaling pathway ko05142 Chagas disease (American trypanosomiasis) ko05161 Hepatitis B ko05164 Influenza A ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05169 Epstein-Barr virus infection ko05418 Fluid shear stress and atherosclerosis Mitogen-activated protein kinase (MAPK) kinase MKK4 T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q91VW5 Golgin subfamily A member 4 Golga4 1031.7 1056.5 1165.2 1297.3 1368.1 1326 0.815102470311169 0.00583152844636655 -0.294946656259033 Nonsignificant None 2 Biological Process:protein targeting to Golgi (GO:0000042),Molecular Function:protein binding (GO:0005515) golgin subfamily A member 4 -- -- -- -- -- IPR000237 [GRIP domain] -- -- P56528 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Cd38 2786.1 2756.6 2871.7 2571.2 2814.3 2514.2 1.06515437295087 0.15578994908147 0.0910625355693975 Nonsignificant None 1 Molecular Function:NAD+ nucleosidase activity (GO:0003953) -- -- ko00760 Nicotinate and nicotinamide metabolism ko01100 Metabolic pathways ko04020 Calcium signaling pathway ko04640 Hematopoietic cell lineage ko04921 Oxytocin signaling pathway ko04970 Salivary secretion ko04972 Pancreatic secretion ko05169 Epstein-Barr virus infection -- -- -- IPR003193 [ADP-ribosyl cyclase (CD38/157)] -- -- Q9JLN9 Serine/threonine-protein kinase mTOR Mtor 968.3 937 816.8 972.9 999.3 945 0.93312080076786 0.253203571551466 -0.0998642320447552 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Molecular Function:kinase activity (GO:0016301),Molecular Function:macromolecular complex binding (GO:0044877) serine/threonine-protein kinase mTOR 2.7.11.1 ko01521 EGFR tyrosine kinase inhibitor resistance ko01522 Endocrine resistance ko04012 ErbB signaling pathway ko04066 HIF-1 signaling pathway ko04072 Phospholipase D signaling pathway ko04136 Autophagy - other ko04140 Autophagy - animal ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04152 AMPK signaling pathway ko04211 Longevity regulating pathway ko04213 Longevity regulating pathway - multiple species ko04218 Cellular senescence ko04371 Apelin signaling pathway ko04630 Jak-STAT signaling pathway ko04659 Th17 cell differentiation ko04910 Insulin signaling pathway ko04919 Thyroid hormone signaling pathway ko04920 Adipocytokine signaling pathway ko04930 Type II diabetes mellitus ko04931 Insulin resistance ko05165 Human papillomavirus infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05206 MicroRNAs in cancer ko05212 Pancreatic cancer ko05214 Glioma ko05215 Prostate cancer ko05221 Acute myeloid leukemia ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer ko05230 Central carbon metabolism in cancer ko05231 Choline metabolism in cancer DNA-dependent protein kinase L Replication, recombination and repair ; IPR000403 [Phosphatidylinositol 3-/4-kinase, catalytic domain] ; IPR003151[PIK-related kinase, FAT] ; IPR003152[FATC domain] ; IPR009076[FKBP12-rapamycin binding domain] ; IPR024585[Domain of unknown function DUF3385, target of rapamycin protein] -- -- Q3U4F0 Sideroflexin-3 Sfxn3 674.1 696 786.3 1072.4 1030.8 924 0.712341437632135 0.00657743176829621 -0.489359179108297 Nonsignificant None 4 Biological Process:ion transport (GO:0006811),Molecular Function:ion transmembrane transporter activity (GO:0015075),Cellular Component:membrane (GO:0016020),Biological Process:transmembrane transport (GO:0055085) -- -- -- Sideroflexin R General function prediction only ; IPR004686 [Tricarboxylate/iron carrier] -- -- Q8CCJ3 E3 UFM1-protein ligase 1 Ufl1 2781 2767.7 3128.9 2691 2744.6 2809.8 1.05241710529507 0.306955587163791 0.0737066024228125 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR018611 [E3 UFM1-protein ligase 1] -- -- Q99L15 Acot1 protein (Fragment) Acot1 730.6 670.4 928.7 638.9 621.6 721.5 1.17542885973764 0.239276511215978 0.233187225669375 Nonsignificant None -- -- acyl-coenzyme A thioesterase 1/2/4 3.1.2.2 ko00062 Fatty acid elongation ko01040 Biosynthesis of unsaturated fatty acids ko01100 Metabolic pathways -- -- -- IPR006862 [Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase] ; IPR014940[BAAT/Acyl-CoA thioester hydrolase C-terminal] -- -- Q8BP40 Lysophosphatidic acid phosphatase type 6 Acp6 1820.8 1722.9 2032.9 2341.6 2260.1 2369.6 0.799936884081879 0.00875914421785183 -0.322041920655151 Nonsignificant None 1 Molecular Function:acid phosphatase activity (GO:0003993) lysophosphatidic acid phosphatase type 6 3.1.3.2 -- Lysosomal & prostatic acid phosphatases I Lipid transport and metabolism ; IPR000560 [Histidine phosphatase superfamily, clade-2] -- -- Q68FG2 Spectrin beta chain Sptbn2 268 307.5 189.6 366.1 376.8 295.9 0.736522911051213 0.100830166304936 -0.441197690948899 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) spectrin beta -- -- Beta-spectrin Z Cytoskeleton ; IPR001715 [Calponin homology domain] ; IPR002017[Spectrin repeat] -- -- Q9DBR1 5-3 exoribonuclease 2 Xrn2 2510.8 2393 2337.3 2134.8 2186.7 2162.9 1.11669545370428 0.00908694890728976 0.159235786235302 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:exonuclease activity (GO:0004527) 5'-3' exoribonuclease 2 3.1.13.- ko03008 Ribosome biogenesis in eukaryotes ko03018 RNA degradation 5'-3' exonuclease HKE1/RAT1 LA Replication, recombination and repair ; RNA processing and modification ; IPR004859 [Putative 5-3 exonuclease] -- -- Q9D8Y0 EF-hand domain-containing protein D2 Efhd2 1993.6 1945.8 2545.6 2297.8 2542.9 2143.5 0.928524383608717 0.500378359409596 -0.106988298189809 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) -- -- -- Predicted Ca2+-binding protein, EF-Hand protein superfamily R General function prediction only ; IPR002048 [EF-hand domain] -- -- P57784 U2 small nuclear ribonucleoprotein A Snrpa1 3232.7 3206.3 2809.4 2755.8 2852.2 2773.7 1.10340384408891 0.108152114373277 0.141960911719537 Nonsignificant None -- -- U2 small nuclear ribonucleoprotein A' -- ko03040 Spliceosome U2-associated snRNP A' protein A RNA processing and modification ; -- -- -- Q3UDZ1 Uncharacterized protein Rhog 2325.1 2442.5 2610.7 2585 2653.7 2460.7 0.958295451593631 0.346012814942989 -0.0614575737544357 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras homolog gene family, member G -- ko05100 Bacterial invasion of epithelial cells ko05132 Salmonella infection Ras-related small GTPase, Rho type R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- Q3U4Y0 H15 domain-containing protein H1f0 3446.1 3159.6 3946 4515.3 4120.9 4809.6 0.784758065715688 0.0338537138334584 -0.349680143035085 Nonsignificant None 4 Cellular Component:nucleosome (GO:0000786),Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634),Biological Process:nucleosome assembly (GO:0006334) histone H1/5 -- -- Histone H1 B Chromatin structure and dynamics ; IPR005818 [Linker histone H1/H5, domain H15] -- -- Q8BH30 Importin subunit alpha Kpna6 518.3 502.5 521.2 544.8 594.3 562.7 0.906099424139147 0.0268811458041133 -0.142258732427542 Nonsignificant None 5 Molecular Function:protein binding (GO:0005515),Cellular Component:nucleus (GO:0005634),Cellular Component:cytoplasm (GO:0005737),Biological Process:protein import into nucleus (GO:0006606),Molecular Function:protein transporter activity (GO:0008565) -- -- -- Karyopherin (importin) alpha U Intracellular trafficking, secretion, and vesicular transport ; IPR000225 [Armadillo] ; IPR002652[Importin-alpha, importin-beta-binding domain] ; IPR032413[Atypical Arm repeat] -- -- Q8VDQ1 Prostaglandin reductase 2 Ptgr2 2238.2 2068.3 2210.4 2616.8 2508.7 2711.5 0.831555442133469 0.00503071018755028 -0.266115639643603 Nonsignificant None 1 Biological Process:oxidation-reduction process (GO:0055114) prostaglandin reductase 2 1.3.1.48 -- Predicted NAD-dependent oxidoreductase R General function prediction only ; IPR013149 [Alcohol dehydrogenase, C-terminal] -- -- P59113 Fermitin family homolog 1 Fermt1 2092.3 2096.2 2101.6 2264.6 2285.7 2341.2 0.912733076978887 0.0118605171651409 -0.131735080046674 Nonsignificant None -- -- kindlin 1 -- -- Mitogen inducible gene product (contains ERM and PH domains) D Cell cycle control, cell division, chromosome partitioning ; IPR001849 [Pleckstrin homology domain] ; IPR019748[FERM central domain] -- -- P29351 Tyrosine-protein phosphatase non-receptor type 6 Ptpn6 2062.7 2218.3 2235.9 1943.3 2173.8 1975.4 1.06965941731637 0.193797152224704 0.0971515114253711 Nonsignificant None 2 Molecular Function:protein tyrosine phosphatase activity (GO:0004725),Biological Process:protein dephosphorylation (GO:0006470) tyrosine-protein phosphatase non-receptor type 6 3.1.3.48 ko04520 Adherens junction ko04630 Jak-STAT signaling pathway ko04650 Natural killer cell mediated cytotoxicity ko04660 T cell receptor signaling pathway ko04662 B cell receptor signaling pathway ko05140 Leishmaniasis ko05205 Proteoglycans in cancer Protein tyrosine phosphatase Corkscrew and related SH2 domain enzymes T Signal transduction mechanisms ; IPR000242 [PTP type protein phosphatase] ; IPR000980[SH2 domain] -- -- Q80X50 Ubiquitin-associated protein 2-like Ubap2l 1939.1 1971.3 1873 1633.9 1693 1667.1 1.15806968362034 0.00143734113411905 0.21172206609815 Nonsignificant None -- -- -- -- -- -- -- -- IPR022166 [Protein of unknown function DUF3697, ubiquitin-associated protein 2] -- -- E9QLL2 Dynamin GTPase Dnm3 183.2 176 202.2 237.5 224.1 219.8 0.823891987085412 0.0133847240023556 -0.279472883583822 Nonsignificant None 2 Molecular Function:GTPase activity (GO:0003924),Molecular Function:GTP binding (GO:0005525) dynamin GTPase 3.6.5.5 ko04072 Phospholipase D signaling pathway ko04144 Endocytosis ko04721 Synaptic vesicle cycle ko04961 Endocrine and other factor-regulated calcium reabsorption ko05100 Bacterial invasion of epithelial cells Vacuolar sorting protein VPS1, dynamin, and related proteins UR Intracellular trafficking, secretion, and vesicular transport ; General function prediction only ; IPR000375 [Dynamin central domain] ; IPR001849[Pleckstrin homology domain] ; IPR003130[Dynamin GTPase effector] ; IPR022812[Dynamin superfamily] -- -- Q9CY64 Biliverdin reductase A Blvra 3371.1 3359.3 3646 3563.4 3529.9 3629.1 0.967731104976498 0.304877059480951 -0.0473218608252931 Nonsignificant None 5 Molecular Function:biliverdin reductase activity (GO:0004074),Molecular Function:zinc ion binding (GO:0008270),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:heme catabolic process (GO:0042167),Biological Process:oxidation-reduction process (GO:0055114) biliverdin reductase 1.3.1.24 ko00860 Porphyrin and chlorophyll metabolism ko01100 Metabolic pathways -- -- -- IPR000683 [Oxidoreductase, N-terminal] ; IPR015249[Biliverdin reductase, catalytic] -- -- Q8R317 Ubiquilin-1 Ubqln1 716.4 713.5 799.3 743.1 815.9 768.8 0.957642409141679 0.404444020038324 -0.0624410515203006 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) ubiquilin -- ko04141 Protein processing in endoplasmic reticulum Ubiquitin-like protein OR Posttranslational modification, protein turnover, chaperones ; General function prediction only ; IPR000626 [Ubiquitin domain] ; IPR015940[Ubiquitin-associated domain] -- -- Q3UQL2 COP9 signalosome complex subunit 3 Cops3 1192.7 1137.6 1230.3 1188.8 1194 1222.5 0.98760158655313 0.633167896782464 -0.0179989407573214 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) COP9 signalosome complex subunit 3 -- -- COP9 signalosome, subunit CSN3 OT Posttranslational modification, protein turnover, chaperones ; Signal transduction mechanisms ; IPR000717 [Proteasome component (PCI) domain] -- -- Q9CRD0 OCIA domain-containing protein 1 Ociad1 1378.8 1451.1 1415.8 1436.1 1403.2 1408.6 0.999482097036183 0.976324744633196 -0.000747369586732539 Nonsignificant None -- -- -- -- -- -- -- -- IPR009764 [Ovarian carcinoma immunoreactive antigen] -- -- Z4YLR0 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 St6galnac6 2775.1 2425.4 2395.6 3234.7 3173.1 3591.8 0.759640385615425 0.0109297240602281 -0.396611487743437 Nonsignificant None 2 Biological Process:protein glycosylation (GO:0006486),Molecular Function:sialyltransferase activity (GO:0008373) N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7F) 2.4.99.- ko00604 Glycosphingolipid biosynthesis - ganglio series ko01100 Metabolic pathways Sialyltransferase G Carbohydrate transport and metabolism ; IPR001675 [Glycosyl transferase family 29] -- -- Q64669 NAD(P)H dehydrogenase [quinone] 1 Nqo1 2801.5 2545.8 3415.5 3385.3 2994.3 3691.2 0.87011955356079 0.253925613419211 -0.20071445544383 Nonsignificant None -- -- NAD(P)H dehydrogenase (quinone) 1.6.5.2 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis ko05200 Pathways in cancer ko05225 Hepatocellular carcinoma ko05418 Fluid shear stress and atherosclerosis -- -- -- IPR003680 [Flavodoxin-like fold] -- -- A2RS68 U1 small nuclear ribonucleoprotein 70 kDa Snrnp70 4288 4722.3 4478.2 4450.9 4633.6 4349.2 1.00407929312103 0.909389478555014 0.00587320482194825 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) U1 small nuclear ribonucleoprotein 70kDa -- ko03040 Spliceosome U1 small nuclear ribonucleoprotein (RRM superfamily) A RNA processing and modification ; IPR000504 [RNA recognition motif domain] ; IPR022023[U1 small nuclear ribonucleoprotein of 70kDa N-terminal] -- -- Q8CEI0 Tyrosine-protein kinase Lyn 1682.1 1713.8 1583.4 1487.6 1489.7 1516.9 1.10793912153442 0.0160737713057851 0.147878611104308 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein binding (GO:0005515),Biological Process:protein phosphorylation (GO:0006468) tyrosine-protein kinase Lyn 2.7.10.2 ko04062 Chemokine signaling pathway ko04064 NF-kappa B signaling pathway ko04611 Platelet activation ko04662 B cell receptor signaling pathway ko04664 Fc epsilon RI signaling pathway ko04666 Fc gamma R-mediated phagocytosis ko04730 Long-term depression ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis Tyrosine kinases T Signal transduction mechanisms ; IPR000980 [SH2 domain] ; IPR001245[Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR001452[SH3 domain] -- -- Q9CPW4 Actin-related protein 2/3 complex subunit 5 Arpc5 4160.7 4249.5 4689.2 4440.8 4444.8 4237.6 0.998186417946842 0.96642351259755 -0.00261882127641421 Nonsignificant None 4 Cellular Component:Arp2/3 protein complex (GO:0005885),Cellular Component:actin cytoskeleton (GO:0015629),Biological Process:regulation of actin filament polymerization (GO:0030833),Biological Process:Arp2/3 complex-mediated actin nucleation (GO:0034314) actin related protein 2/3 complex, subunit 5 -- ko04144 Endocytosis ko04666 Fc gamma R-mediated phagocytosis ko04810 Regulation of actin cytoskeleton ko05100 Bacterial invasion of epithelial cells ko05132 Salmonella infection Actin-related protein Arp2/3 complex, subunit ARPC5 Z Cytoskeleton ; IPR006789 [Actin-related protein 2/3 complex subunit 5] -- -- Q8BWF0 Succinate-semialdehyde dehydrogenase, mitochondrial Aldh5a1 1209.7 1135.9 1313.6 1439.1 1401.7 1490.3 0.844866200272448 0.0177010161866255 -0.243205212057821 Nonsignificant None 3 Biological Process:metabolic process (GO:0008152),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) succinate-semialdehyde dehydrogenase 1.2.1.24 ko00250 Alanine, aspartate and glutamate metabolism ko00650 Butanoate metabolism ko01100 Metabolic pathways Aldehyde dehydrogenase C Energy production and conversion ; IPR015590 [Aldehyde dehydrogenase domain] -- -- F8WJ93 Echinoderm microtubule-associated protein-like 4 Eml4 2014.7 2130.1 2497.8 2403 2575.3 2322.4 0.909857958825866 0.251158221136363 -0.136286756270812 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) echinoderm microtubule-associated protein-like 4 -- ko05200 Pathways in cancer ko05223 Non-small cell lung cancer Uncharacterized conserved protein, contains HELP and WD40 domains S Function unknown ; IPR001680 [WD40 repeat] ; IPR005108[HELP] -- -- P06909 Complement factor H Cfh 3192.2 3382.6 3030.3 1943.3 2039.7 1968.4 1.61392277447323 0.000325483619494688 0.690571547915579 Significant up -- -- complement factor H -- ko04610 Complement and coagulation cascades ko05150 Staphylococcus aureus infection -- -- -- IPR000436 [Sushi/SCR/CCP domain] -- -- O89001 Carboxypeptidase D Cpd 1748.6 1689.4 2049.7 2262.6 2253.1 2210.3 0.815893547427892 0.0631061941144379 -0.293547164034233 Nonsignificant None 3 Molecular Function:metallocarboxypeptidase activity (GO:0004181),Biological Process:proteolysis (GO:0006508),Molecular Function:zinc ion binding (GO:0008270) carboxypeptidase D 3.4.17.22 -- Zinc carboxypeptidase R General function prediction only ; IPR000834 [Peptidase M14, carboxypeptidase A] -- -- Q80XK9 Serine hydrolase-like Serhl 2647.7 2617.7 2959.4 2909 3324.9 3440.8 0.850134887903501 0.0682683620415822 -0.234236328142641 Nonsignificant None -- -- -- -- -- Predicted hydrolase/acyltransferase (alpha/beta hydrolase superfamily) R General function prediction only ; IPR000073 [Alpha/beta hydrolase fold-1] -- -- P50543 Protein S100-A11 S100a11 6062.4 6434.6 3704.2 2892.9 2957.3 2795.6 1.87388095954105 0.0980501854677744 0.906029307034111 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) -- -- -- -- -- -- IPR002048 [EF-hand domain] ; IPR013787[S100/CaBP-9k-type, calcium binding, subdomain] -- -- P28652 Calcium/calmodulin-dependent protein kinase type II subunit beta Camk2b 68.3 58.6 56 69 62.6 63.7 0.936507936507937 0.384042890902868 -0.094636874138075 Nonsignificant None 5 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:calmodulin-dependent protein kinase activity (GO:0004683),Molecular Function:calmodulin binding (GO:0005516),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) calcium/calmodulin-dependent protein kinase (CaM kinase) II 2.7.11.17 ko04012 ErbB signaling pathway ko04020 Calcium signaling pathway ko04024 cAMP signaling pathway ko04066 HIF-1 signaling pathway ko04114 Oocyte meiosis ko04217 Necroptosis ko04261 Adrenergic signaling in cardiomyocytes ko04310 Wnt signaling pathway ko04360 Axon guidance ko04713 Circadian entrainment ko04720 Long-term potentiation ko04722 Neurotrophin signaling pathway ko04725 Cholinergic synapse ko04728 Dopaminergic synapse ko04740 Olfactory transduction ko04750 Inflammatory mediator regulation of TRP channels ko04911 Insulin secretion ko04912 GnRH signaling pathway ko04916 Melanogenesis ko04921 Oxytocin signaling pathway ko04922 Glucagon signaling pathway ko04925 Aldosterone synthesis and secretion ko04971 Gastric acid secretion ko05031 Amphetamine addiction ko05152 Tuberculosis ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05214 Glioma Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR013543[Calcium/calmodulin-dependent protein kinase II, association-domain] -- -- Q543F3 Calponin Cnn2 1912.9 2095.7 2307.1 1870.6 1825.7 1796.8 1.14975150643535 0.0771732446675238 0.201322087976929 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Calponin Z Cytoskeleton ; IPR000557 [Calponin repeat] ; IPR001715[Calponin homology domain] -- -- A0A0R4J187 X-ray repair cross-complementing protein 6 Xrcc6 2080.9 1862.8 2030.2 2183 2102.2 2351.3 0.90015821592707 0.0886632636679813 -0.151749496475693 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Molecular Function:ATP-dependent DNA helicase activity (GO:0004003),Biological Process:double-strand break repair via nonhomologous end joining (GO:0006303) ATP-dependent DNA helicase 2 subunit 1 -- ko03450 Non-homologous end-joining DNA-binding subunit of a DNA-dependent protein kinase (Ku70 autoantigen) L Replication, recombination and repair ; IPR003034 [SAP domain] ; IPR005160[Ku70/Ku80 C-terminal arm] ; IPR005161[Ku70/Ku80, N-terminal alpha/beta] ; IPR006164[Ku70/Ku80 beta-barrel domain] -- -- Q9JLV6 Bifunctional polynucleotide phosphatase/kinase Pnkp 2728.3 2909.8 2839.3 2381.3 2381 2517.9 1.16444603170243 0.00462455881448332 0.21964377686134 Nonsignificant None -- -- -- -- -- Polynucleotide kinase 3' phosphatase L Replication, recombination and repair ; IPR013954 [Polynucleotide kinase 3 phosphatase] -- -- Q6PGB6 N-alpha-acetyltransferase 50 Naa50 2542.7 2450 2396.4 2190.8 2229 2264.3 1.10547418500621 0.00789945225430981 0.144665335784288 Nonsignificant None 1 Molecular Function:N-acetyltransferase activity (GO:0008080) N-alpha-acetyltransferase 50 2.3.1.258 -- Predicted N-acetyltransferase R General function prediction only ; IPR000182 [GNAT domain] -- -- P47811 Mitogen-activated protein kinase 14 Mapk14 1667.8 1806.1 1820.2 1645.1 1712 1704.4 1.04595475649511 0.217471081063418 0.0648204481509899 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) p38 MAP kinase 2.7.11.24 ko01522 Endocrine resistance ko04010 MAPK signaling pathway ko04015 Rap1 signaling pathway ko04068 FoxO signaling pathway ko04071 Sphingolipid signaling pathway ko04218 Cellular senescence ko04261 Adrenergic signaling in cardiomyocytes ko04370 VEGF signaling pathway ko04380 Osteoclast differentiation ko04550 Signaling pathways regulating pluripotency of stem cells ko04611 Platelet activation ko04620 Toll-like receptor signaling pathway ko04621 NOD-like receptor signaling pathway ko04622 RIG-I-like receptor signaling pathway ko04657 IL-17 signaling pathway ko04658 Th1 and Th2 cell differentiation ko04659 Th17 cell differentiation ko04660 T cell receptor signaling pathway ko04664 Fc epsilon RI signaling pathway ko04668 TNF signaling pathway ko04670 Leukocyte transendothelial migration ko04722 Neurotrophin signaling pathway ko04723 Retrograde endocannabinoid signaling ko04728 Dopaminergic synapse ko04750 Inflammatory mediator regulation of TRP channels ko04912 GnRH signaling pathway ko04914 Progesterone-mediated oocyte maturation ko04917 Prolactin signaling pathway ko04926 Relaxin signaling pathway ko04933 AGE-RAGE signaling pathway in diabetic complications ko05014 Amyotrophic lateral sclerosis (ALS) ko05132 Salmonella infection ko05133 Pertussis ko05140 Leishmaniasis ko05142 Chagas disease (American trypanosomiasis) ko05145 Toxoplasmosis ko05152 Tuberculosis ko05160 Hepatitis C ko05164 Influenza A ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05169 Epstein-Barr virus infection ko05205 Proteoglycans in cancer ko05418 Fluid shear stress and atherosclerosis Mitogen-activated protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q8BH43 Actin-binding protein WASF2 Wasf2 2920.5 3055.2 2991.2 2940.2 3214.5 2863 0.99436663450769 0.888647907058916 -0.00815020662033217 Nonsignificant None 1 Molecular Function:actin binding (GO:0003779) WAS protein family, member 2 -- ko04520 Adherens junction ko04666 Fc gamma R-mediated phagocytosis ko04810 Regulation of actin cytoskeleton ko05100 Bacterial invasion of epithelial cells ko05132 Salmonella infection ko05231 Choline metabolism in cancer Wiskott Aldrich syndrome proteins Z Cytoskeleton ; IPR003124 [WH2 domain] -- -- Q54AH9 Beta-2-globin (Fragment) Hbb-b2 591.9 588.3 601.4 640.9 915.2 788.7 0.759808938928693 0.141075952935076 -0.396291409901752 Nonsignificant None 2 Molecular Function:oxygen binding (GO:0019825),Molecular Function:heme binding (GO:0020037) hemoglobin subunit beta -- ko05143 African trypanosomiasis ko05144 Malaria Globins and related hemoproteins C Energy production and conversion ; IPR000971 [Globin] -- -- Q8BXZ1 Protein disulfide-isomerase TMX3 Tmx3 1564.9 1589 1868.9 1846.8 1888.2 1788.3 0.909383882823674 0.176516395439741 -0.137038659725526 Nonsignificant None 1 Biological Process:cell redox homeostasis (GO:0045454) thioredoxin domain-containing protein 10 5.3.4.1 -- Uncharacterized conserved protein, contains thioredoxin domain R General function prediction only ; IPR013766 [Thioredoxin domain] -- -- Q9QXB9 Developmentally-regulated GTP-binding protein 2 Drg2 2588.6 2579.2 2562.6 2178.8 2201 2343.5 1.14979251260542 0.0209335559163681 0.201373541132618 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) uncharacterized protein -- -- GTP-binding protein DRG2 (ODN superfamily) T Signal transduction mechanisms ; IPR004095 [TGS] ; IPR006073[GTP binding domain] ; IPR031662[GTP binding protein, second domain] -- -- E9PWG6 Non-SMC condensin I complex, subunit G Ncapg 1297.4 1350.2 1140.2 894.3 927.9 907.1 1.38782838090353 0.0280795678556927 0.472829175028905 Nonsignificant None -- -- condensin complex subunit 3 -- Chromosome condensation complex Condensin, subunit G BD Chromatin structure and dynamics ; Cell cycle control, cell division, chromosome partitioning ; IPR025977 [Nuclear condensin complex subunit 3, C-terminal domain] -- -- Q9DD20 Thiol S-methyltransferase METTL7B Mettl7b 2534.3 2599.1 6086.3 4357.1 3941.3 3747.4 0.931420080027894 0.837270095010515 -0.102496110040274 Nonsignificant None 2 Biological Process:metabolic process (GO:0008152),Molecular Function:methyltransferase activity (GO:0008168) -- -- -- Predicted methyltransferase R General function prediction only ; IPR013216 [Methyltransferase type 11] -- -- J3QNU6 Beta-arrestin-1 Arrb1 1735.7 1693.2 1938.7 1958.3 1900.6 1995.8 0.916801885664509 0.114382436601859 -0.125318083475749 Nonsignificant None -- -- beta-arrestin -- ko04010 MAPK signaling pathway ko04062 Chemokine signaling pathway ko04144 Endocytosis ko04340 Hedgehog signaling pathway ko04740 Olfactory transduction ko04926 Relaxin signaling pathway ko05032 Morphine addiction Arrestin T Signal transduction mechanisms ; IPR011021 [Arrestin-like, N-terminal] ; IPR011022[Arrestin C-terminal-like domain] -- -- H9KV15 Protein SON Son 2205.4 2303.5 2330.2 2292.5 2318.6 2461.1 0.96703995927717 0.295960839536276 -0.0483525900250297 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q3TDN2 FAS-associated factor 2 Faf2 1627.3 1538.8 1343.5 1507.1 1597.5 1572.4 0.964207825529185 0.560728392530956 -0.0525839561650915 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) FAS-associated factor 2 -- -- Predicted regulator of the ubiquitin pathway (contains UAS and UBX domains) T Signal transduction mechanisms ; IPR001012 [UBX domain] -- -- Q6ZWQ6 E2 ubiquitin-conjugating enzyme Ube2k 1541.6 1491.3 1413.3 1507.3 1554.6 1476 0.97979241499372 0.523345388221381 -0.0294519717635389 Nonsignificant None -- -- ubiquitin-conjugating enzyme (huntingtin interacting protein 2) 2.3.2.23 ko04120 Ubiquitin mediated proteolysis Ubiquitin-protein ligase O Posttranslational modification, protein turnover, chaperones ; IPR000608 [Ubiquitin-conjugating enzyme E2] ; IPR015940[Ubiquitin-associated domain] -- -- Q3TJC2 SGNH_hydro domain-containing protein Pafah1b3 2847.8 2777.1 3268.7 3422.7 3679.9 3603.8 0.830680714339087 0.02431221734543 -0.267634034683513 Nonsignificant None -- -- platelet-activating factor acetylhydrolase IB subunit beta/gamma 3.1.1.47 ko00565 Ether lipid metabolism ko01100 Metabolic pathways Attractin and platelet-activating factor acetylhydrolase TV Signal transduction mechanisms ; Defense mechanisms ; IPR013830 [SGNH hydrolase-type esterase domain] -- -- Q9Z0Z4 Hephaestin Heph 1329 1329.9 1357.3 1450.7 1576.5 1428.5 0.901362299975312 0.03564653307724 -0.149820985166997 Nonsignificant None 3 Molecular Function:copper ion binding (GO:0005507),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) hephaestin 1.16.3.1 ko00860 Porphyrin and chlorophyll metabolism ko04978 Mineral absorption Multicopper oxidases Q Secondary metabolites biosynthesis, transport and catabolism ; IPR011706 [Multicopper oxidase, type 2] ; IPR011707[Multicopper oxidase, type 3] -- -- Q8VC94 60S ribosomal protein L11 Rpl11 3985.2 3852.1 2316.2 2041.8 2094.3 2252.9 1.58921583972453 0.142003337617048 0.668315077961089 Nonsignificant None -- -- large subunit ribosomal protein L11e -- ko03010 Ribosome 60S ribosomal protein L11 J Translation, ribosomal structure and biogenesis ; IPR031309 [Ribosomal protein L5, C-terminal] ; IPR031310[Ribosomal protein L5, N-terminal] -- -- O35864 COP9 signalosome complex subunit 5 Cops5 2307 2303.8 2088.4 2092.9 2138.5 2209.8 1.0400546482022 0.342565622525498 0.0566593347307737 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) COP9 signalosome complex subunit 5 3.4.-.- -- COP9 signalosome, subunit CSN5 OT Posttranslational modification, protein turnover, chaperones ; Signal transduction mechanisms ; IPR000555 [JAB1/MPN/MOV34 metalloenzyme domain] -- -- E9QM90 RAB11-binding protein RELCH Relch 1315.9 1438.4 1635.3 1766.2 1805.1 1620.3 0.845519685646044 0.069765168432767 -0.242089750597097 Nonsignificant None -- -- -- -- -- Protein phosphatase 2A regulatory subunit A and related proteins T Signal transduction mechanisms ; -- -- -- Q99M73 Keratin, type II cuticular Hb4 Krt84 379.4 371 446.7 440.4 419.7 497 0.882101540048633 0.184305902568009 -0.180983358727161 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) type II keratin, basic -- -- -- -- -- IPR001664 [Intermediate filament protein] ; IPR032444[Keratin type II head] -- -- Q91VJ2 Caveolae-associated protein 3 Cavin3 2723.7 2930.6 2832.2 3422.5 3445.1 3315.7 0.833374249997545 0.00140762348832593 -0.262963571250511 Nonsignificant None -- -- -- -- -- -- -- -- IPR026752 [Cavin family] -- -- Q7TT37 Elongator complex protein 1 Elp1 1501.1 1462.9 1378.2 1359.8 1370.6 1495.3 1.02756939678633 0.530690574653934 0.0392358294482479 Nonsignificant None 2 Biological Process:tRNA wobble uridine modification (GO:0002098),Cellular Component:Elongator holoenzyme complex (GO:0033588) elongator complex protein 1 -- -- IkappaB kinase complex, IKAP component K Transcription ; IPR006849 [Elongator complex subunit Iki3] -- -- G3UXA6 Polypyrimidine tract-binding protein 3 Ptbp3 1915.2 1817.7 1358.7 1436.9 1524.3 1340.1 1.18373514983842 0.216396149713345 0.243346326949119 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) polypyrimidine tract-binding protein 3 -- -- Polypyrimidine tract-binding protein A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- Q62048 Astrocytic phosphoprotein PEA-15 Pea15 1713.2 1906.8 1862.6 1848.2 1843.7 1973 0.967819378982859 0.447894155460298 -0.0471902678006099 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Biological Process:regulation of apoptotic process (GO:0042981) -- -- -- Caspase, apoptotic cysteine protease D Cell cycle control, cell division, chromosome partitioning ; IPR001875 [Death effector domain] -- -- A0A0N4SW28 Guanine nucleotide-binding protein subunit gamma Gng12 2189.4 2268.5 2315.4 2568.7 2716.4 2532.1 0.866461136979993 0.00663955661282821 -0.206793052649759 Nonsignificant None 3 Molecular Function:signal transducer activity (GO:0004871),Cellular Component:heterotrimeric G-protein complex (GO:0005834),Biological Process:G-protein coupled receptor signaling pathway (GO:0007186) guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 -- ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04062 Chemokine signaling pathway ko04151 PI3K-Akt signaling pathway ko04371 Apelin signaling pathway ko04713 Circadian entrainment ko04723 Retrograde endocannabinoid signaling ko04724 Glutamatergic synapse ko04725 Cholinergic synapse ko04726 Serotonergic synapse ko04727 GABAergic synapse ko04728 Dopaminergic synapse ko04810 Regulation of actin cytoskeleton ko04926 Relaxin signaling pathway ko05032 Morphine addiction ko05034 Alcoholism ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05200 Pathways in cancer G protein gamma subunit T Signal transduction mechanisms ; IPR015898 [G-protein gamma-like domain] -- -- B2RY56 RNA-binding protein 25 Rbm25 2192.2 2544.2 2573.6 2379.2 2429.6 2363.9 1.01914202462113 0.731026313726965 0.0273551152318174 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Biological Process:mRNA processing (GO:0006397) RNA-binding protein 25 -- ko03040 Spliceosome U1 snRNP complex, subunit SNU71 and related PWI-motif proteins A RNA processing and modification ; IPR000504 [RNA recognition motif domain] ; IPR002483[PWI domain] -- -- A0A158RFV1 Ribonucleoprotein, PTB-binding 1 Raver1 1204.3 1097.8 1292.7 1256 1275.1 1282 0.942749993443655 0.32511367433242 -0.0850528595536311 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- -- -- -- IPR000504 [RNA recognition motif domain] -- -- E9PV38 Carboxylic ester hydrolase Ces2g 363.5 337.6 281.9 406 431.5 442.7 0.767848773629121 0.0199270815374285 -0.381105892037731 Nonsignificant None -- -- -- -- ko00983 Drug metabolism - other enzymes Carboxylesterase and related proteins R General function prediction only ; IPR002018 [Carboxylesterase, type B] -- -- O88441 Metaxin-2 Mtx2 1572.6 1545 1786.2 1941.9 1895.2 1951.4 0.847162477325732 0.0195624636942754 -0.239289404252723 Nonsignificant None 2 Cellular Component:mitochondrial outer membrane (GO:0005741),Biological Process:protein targeting to mitochondrion (GO:0006626) metaxin -- -- Mitochondrial outer membrane protein Metaxin 2, Metaxin 1-binding protein MU Cell wall/membrane/envelope biogenesis ; Intracellular trafficking, secretion, and vesicular transport ; IPR019564 [Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain] ; IPR033468[Metaxin, glutathione S-transferase domain] -- -- G5E884 Non-specific serine/threonine protein kinase Pak1 948.8 889.8 641.8 619.9 624.5 640.7 1.3157922656623 0.168794425783282 0.395931737587328 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) p21-activated kinase 1 2.7.11.1 ko04010 MAPK signaling pathway ko04012 ErbB signaling pathway ko04014 Ras signaling pathway ko04024 cAMP signaling pathway ko04062 Chemokine signaling pathway ko04360 Axon guidance ko04392 Hippo signaling pathway - multiple species ko04510 Focal adhesion ko04650 Natural killer cell mediated cytotoxicity ko04660 T cell receptor signaling pathway ko04666 Fc gamma R-mediated phagocytosis ko04810 Regulation of actin cytoskeleton ko05205 Proteoglycans in cancer ko05211 Renal cell carcinoma p21-activated serine/threonine protein kinase T Signal transduction mechanisms ; IPR000095 [CRIB domain] ; IPR000719[Protein kinase domain] -- -- Q9CXS4 Centromere protein V Cenpv 1336.2 1285 1246.8 1523.4 1376.3 1601.3 0.859364585647634 0.0408478150443415 -0.21865776990871 Nonsignificant None 2 Biological Process:metabolic process (GO:0008152),Molecular Function:carbon-sulfur lyase activity (GO:0016846) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR006913 [Glutathione-dependent formaldehyde-activating enzyme/centromere protein V] -- -- Q6NXX6 V-type proton ATPase subunit a Atp6v0a1 1097.8 1114.5 1134.5 1194.3 1258.6 1203.4 0.915351584935591 0.0104880003740747 -0.127602108411439 Nonsignificant None 2 Molecular Function:hydrogen ion transmembrane transporter activity (GO:0015078),Biological Process:ATP hydrolysis coupled proton transport (GO:0015991) V-type H+-transporting ATPase subunit a -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04142 Lysosome ko04145 Phagosome ko04721 Synaptic vesicle cycle ko04966 Collecting duct acid secretion ko05152 Tuberculosis ko05165 Human papillomavirus infection ko05323 Rheumatoid arthritis Vacuolar H+-ATPase V0 sector, subunit a C Energy production and conversion ; IPR002490 [V-type ATPase, V0 complex, 116kDa subunit family] -- -- W6PPA1 270-kDa ankyrinG Ank3 701.6 701.7 802 1063.6 1003.2 1050.7 0.707393744987971 0.00134407296903579 -0.499414632584086 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Biological Process:signal transduction (GO:0007165) ankyrin -- ko05205 Proteoglycans in cancer Ankyrin M Cell wall/membrane/envelope biogenesis ; IPR000488 [Death domain] ; IPR000906[ZU5 domain] ; IPR002110[Ankyrin repeat] ; IPR020683[Ankyrin repeat-containing domain] -- -- Q9CPQ8 ATP synthase subunit g, mitochondrial Atp5mg 4385.6 4974.7 3433.6 3347.4 3194.3 3166.3 1.31787185826123 0.147032074750333 0.398210098389554 Nonsignificant None 2 Molecular Function:hydrogen ion transmembrane transporter activity (GO:0015078),Biological Process:ATP synthesis coupled proton transport (GO:0015986) F-type H+-transporting ATPase subunit g -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways Mitochondrial F1F0-ATP synthase, subunit g/ATP20 C Energy production and conversion ; IPR006808 [ATP synthase, F0 complex, subunit G, mitochondrial] -- -- P11881 Inositol 1,4,5-trisphosphate receptor type 1 Itpr1 947 966.5 1005.3 999.5 988.5 1019.7 0.970442530837517 0.201691152045216 -0.0432853151587583 Nonsignificant None 6 Molecular Function:ion channel activity (GO:0005216),Molecular Function:calcium channel activity (GO:0005262),Biological Process:ion transport (GO:0006811),Cellular Component:membrane (GO:0016020),Biological Process:transmembrane transport (GO:0055085),Biological Process:calcium ion transmembrane transport (GO:0070588) inositol 1,4,5-triphosphate receptor type 1 -- ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04070 Phosphatidylinositol signaling system ko04114 Oocyte meiosis ko04140 Autophagy - animal ko04210 Apoptosis ko04218 Cellular senescence ko04270 Vascular smooth muscle contraction ko04371 Apelin signaling pathway ko04540 Gap junction ko04611 Platelet activation ko04621 NOD-like receptor signaling pathway ko04713 Circadian entrainment ko04720 Long-term potentiation ko04723 Retrograde endocannabinoid signaling ko04724 Glutamatergic synapse ko04725 Cholinergic synapse ko04726 Serotonergic synapse ko04728 Dopaminergic synapse ko04730 Long-term depression ko04750 Inflammatory mediator regulation of TRP channels ko04912 GnRH signaling pathway ko04915 Estrogen signaling pathway ko04918 Thyroid hormone synthesis ko04921 Oxytocin signaling pathway ko04922 Glucagon signaling pathway ko04924 Renin secretion ko04925 Aldosterone synthesis and secretion ko04970 Salivary secretion ko04971 Gastric acid secretion ko04972 Pancreatic secretion ko05010 Alzheimer's disease ko05016 Huntington's disease ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05205 Proteoglycans in cancer Inositol 1,4,5-trisphosphate receptor T Signal transduction mechanisms ; IPR000699 [RIH (RyR and IP3R Homology) domain] ; IPR005821[Ion transport domain] ; IPR013662[RyR/IP3R Homology associated domain] ; IPR014821[Inositol 1,4,5-trisphosphate/ryanodine receptor] ; IPR016093[MIR motif] -- -- P81117 Nucleobindin-2 Nucb2 1817.5 1900.6 1830.7 1647.6 1701.1 1685.5 1.10222080966191 0.00479004958795825 0.140413270273111 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) nucleobindin -- -- DNA-binding protein of the nucleobindin family R General function prediction only ; IPR002048 [EF-hand domain] -- -- A0A668KLB7 Chloride intracellular channel protein Clic5 802.2 715 880 1743 1553.7 1363.4 0.514409562026566 0.00322110161157465 -0.959010634647449 Significant down 1 Molecular Function:protein binding (GO:0005515) chloride intracellular channel protein 5 -- -- Intracellular Cl- channel CLIC, contains GST domain P Inorganic ion transport and metabolism ; IPR004045 [Glutathione S-transferase, N-terminal] -- -- Q9JKB3 Y-box-binding protein 3 Ybx3 1579.2 1687.1 1825.7 1622.3 1695.6 1507.1 1.05533678756477 0.378684240679458 0.0777034768585528 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) cold shock domain protein A -- ko04530 Tight junction Predicted RNA-binding protein containing PIN domain and invovled in translation or RNA processing J Translation, ribosomal structure and biogenesis ; IPR002059 [Cold-shock protein, DNA-binding] -- CSD P62331 ADP-ribosylation factor 6 Arf6 1775.8 1614.5 1802.4 2043.2 2052.7 2068 0.842437417868557 0.0297666309820613 -0.247358578069625 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) ADP-ribosylation factor 6 -- ko04014 Ras signaling pathway ko04072 Phospholipase D signaling pathway ko04144 Endocytosis ko04666 Fc gamma R-mediated phagocytosis GTP-binding ADP-ribosylation factor Arf6 (dArf3) U Intracellular trafficking, secretion, and vesicular transport ; IPR006689 [Small GTPase superfamily, ARF/SAR type] -- -- Q8BFS6 Serine/threonine-protein phosphatase CPPED1 Cpped1 1102.1 1091 1379.3 1456.9 1371.4 1461.5 0.832766096321507 0.0726376771517037 -0.264016760237167 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) serine/threonine-protein phosphatase CPPED1 3.1.3.16 -- Purple acid phosphatase G Carbohydrate transport and metabolism ; IPR004843 [Calcineurin-like phosphoesterase domain, ApaH type] -- -- Q8C196 Carbamoyl-phosphate synthase [ammonia], mitochondrial Cps1 1357 1409.5 1834.3 1440.2 1636.5 1418.6 1.02346895646564 0.842815722899689 0.0334673436585527 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) carbamoyl-phosphate synthase (ammonia) 6.3.4.16 ko00220 Arginine biosynthesis ko00250 Alanine, aspartate and glutamate metabolism ko00910 Nitrogen metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids Multifunctional pyrimidine synthesis protein CAD (includes carbamoyl-phophate synthetase, aspartate transcarbamylase, and glutamine amidotransferase) R General function prediction only ; IPR002474 [Carbamoyl-phosphate synthase, small subunit N-terminal domain] ; IPR005479[Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain] ; IPR005480[Carbamoyl-phosphate synthetase, large subunit oligomerisation domain] ; IPR011607[Methylglyoxal synthase-like domain] ; IPR017926[Glutamine amidotransferase] -- -- A0A494BB95 Eukaryotic translation initiation factor 4C Eif1a 484.5 461.4 398.7 354.3 397.3 429 1.13891241741487 0.178556339208513 0.187656807783983 Nonsignificant None 3 Molecular Function:RNA binding (GO:0003723),Molecular Function:translation initiation factor activity (GO:0003743),Biological Process:translational initiation (GO:0006413) translation initiation factor 1A -- ko03013 RNA transport Translation initiation factor 1A (eIF-1A) J Translation, ribosomal structure and biogenesis ; IPR006196 [RNA-binding domain, S1, IF1 type] -- -- Q9QZE7 Translin-associated protein X Tsnax 1408.3 1358.3 1484.8 1480.3 1492.3 1390.4 0.974421269768508 0.488822445099648 -0.0373824700024782 Nonsignificant None 1 Molecular Function:sequence-specific DNA binding (GO:0043565) -- -- -- Translin-associated protein X R General function prediction only ; IPR002848 [Translin family] -- -- A0A0R4J0V5 DNA-directed RNA polymerase subunit Polr2a 2009.7 1948.2 1831.2 1802 1861.4 1844.6 1.0510348583878 0.165179312777341 0.0718105181956658 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Molecular Function:DNA-directed 5'-3' RNA polymerase activity (GO:0003899),Biological Process:transcription from RNA polymerase II promoter (GO:0006366) DNA-directed RNA polymerase II subunit RPB1 2.7.7.6 ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways ko03020 RNA polymerase ko05016 Huntington's disease ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection RNA polymerase II, large subunit K Transcription ; IPR000684 [RNA polymerase II, heptapeptide repeat, eukaryotic] ; IPR000722[RNA polymerase, alpha subunit] ; IPR007066[RNA polymerase Rpb1, domain 3] ; IPR007073[RNA polymerase Rpb1, domain 7] ; IPR007075[RNA polymerase Rpb1, domain 6] ; IPR007080[RNA polymerase Rpb1, domain 1] ; IPR007081[RNA polymerase Rpb1, domain 5] ; IPR007083[RNA polymerase Rpb1, domain 4] -- -- Q8K2Z4 Condensin complex subunit 1 Ncapd2 1888.3 1815.9 1641.4 1522.8 1536.4 1549.2 1.15996875271244 0.077047188026278 0.21408594249596 Nonsignificant None -- -- condensin complex subunit 1 -- Chromosome condensation complex Condensin, subunit D2 BD Chromatin structure and dynamics ; Cell cycle control, cell division, chromosome partitioning ; IPR024324 [Condensin complex subunit 1, N-terminal] ; IPR032682[Condensin complex subunit 1, C-terminal] -- -- Q3TYL9 2,3-cyclic-nucleotide 3-phosphodiesterase Cnp 1467.5 1397.9 1401.8 1584.3 1759.1 1666.4 0.851770529761667 0.0110286134422388 -0.23146327965302 Nonsignificant None 3 Molecular Function:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity (GO:0004113),Biological Process:cyclic nucleotide catabolic process (GO:0009214),Cellular Component:membrane (GO:0016020) 2',3'-cyclic-nucleotide 3'-phosphodiesterase 3.1.4.37 -- Predicted MutS-related protein involved in mismatch repair L Replication, recombination and repair ; IPR008431 [Cyclic nucleotide phosphodiesterase] -- -- P54923 ADP-ribosylhydrolase ARH1 Adprh 3172.4 3227.5 3435.5 3245 3391.2 3294.2 0.990433416579393 0.74512202628195 -0.0138681039215355 Nonsignificant None -- -- ADP-ribosylarginine hydrolase 3.2.2.19 -- -- -- -- IPR005502 [ADP-ribosylation/Crystallin J1] -- -- Q9JK48 Endophilin-B1 Sh3glb1 1419.3 1365.8 1565.3 1458.3 1534.4 1416.3 0.986709004309367 0.79089713779499 -0.0193034204783502 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:cytoplasm (GO:0005737) endophilin-B1 -- ko04140 Autophagy - animal ko04144 Endocytosis SH3 domain protein SH3GLB T Signal transduction mechanisms ; IPR001452 [SH3 domain] ; IPR004148[BAR domain] -- -- Q9QWK5 Baculoviral IAP repeat-containing protein 1a Naip1 923.5 871.9 896 883.3 919.8 857.8 1.01146228719606 0.685913305922348 0.0164425293974102 Nonsignificant None -- -- baculoviral IAP repeat-containing protein 1 -- ko04621 NOD-like receptor signaling pathway ko05134 Legionellosis -- -- -- IPR001370 [BIR repeat] -- -- Q9Z2Q6 Septin-5 Septin5 1914.5 1883.4 2176.3 2098 2115.5 2232.2 0.926850458445165 0.198164609358067 -0.109591507129345 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) septin 5 -- ko05012 Parkinson's disease Septin family protein (P-loop GTPase) DZU Cell cycle control, cell division, chromosome partitioning ; Cytoskeleton ; Intracellular trafficking, secretion, and vesicular transport ; IPR030379 [Septin-type guanine nucleotide-binding (G) domain] -- -- Q61074 Protein phosphatase 1G Ppm1g 3409.3 3698.5 4196 3448.2 3529.2 3341.5 1.09544622004283 0.23670982780692 0.131518658237738 Nonsignificant None 1 Molecular Function:catalytic activity (GO:0003824) protein phosphatase 1G 3.1.3.16 -- Serine/threonine protein phosphatase T Signal transduction mechanisms ; IPR001932 [PPM-type phosphatase domain] -- -- Q8CB12 Gasdermin-C3 Gsdmc3 49.7 30.1 37.4 48 47.1 54.2 0.784996651038178 0.156303982922087 -0.349241595712293 Nonsignificant None -- -- gasdermin-C -- -- -- -- -- IPR007677 [Gasdermin] -- -- A0A571BG95 Active breakpoint cluster region-related protein Abr 861.8 862 985 1001.1 1008.3 1024.8 0.892755915892163 0.0596970135968992 -0.163662305952799 Nonsignificant None 7 Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Molecular Function:GTPase activator activity (GO:0005096),Molecular Function:protein binding (GO:0005515),Biological Process:protein phosphorylation (GO:0006468),Biological Process:signal transduction (GO:0007165),Biological Process:regulation of Rho protein signal transduction (GO:0035023) active breakpoint cluster region-related protein -- -- Rac GTPase-activating protein BCR/ABR T Signal transduction mechanisms ; IPR000008 [C2 domain] ; IPR000198[Rho GTPase-activating protein domain] ; IPR000219[Dbl homology (DH) domain] ; IPR001849[Pleckstrin homology domain] ; IPR015123[Bcr-Abl oncoprotein oligomerisation] -- -- O89086 RNA-binding protein 3 Rbm3 3774.2 3921.9 3286.1 3062.5 3160.8 3427.6 1.13794568382223 0.114957547562511 0.186431696879605 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) RNA-binding protein 3 -- -- FOG: RRM domain R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- Q8CHP8 Glycerol-3-phosphate phosphatase Pgp 2667.7 2636.4 2751.1 2924.9 2900.1 2861.8 0.927291983238937 0.00561543678716508 -0.10890441251555 Nonsignificant None -- -- -- -- ko00630 Glyoxylate and dicarboxylate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism p-Nitrophenyl phosphatase P Inorganic ion transport and metabolism ; IPR006357 [HAD-superfamily hydrolase, subfamily IIA] -- -- Q9JLI8 Squamous cell carcinoma antigen recognized by T-cells 3 Sart3 1485 1397.5 1462.5 1450.7 1482.5 1521.7 0.975330534916609 0.333219431506052 -0.0360368706169945 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- RNA-binding protein SART3 (RRM superfamily) A RNA processing and modification ; IPR000504 [RNA recognition motif domain] ; IPR008669[LSM-interacting domain] -- -- Q4FJZ6 GCS light chain Gclm 2004.7 2093.2 2110.1 1981.3 2047 2027.4 1.02514985881071 0.252968442673266 0.0358348216916168 Nonsignificant None -- -- glutamate--cysteine ligase regulatory subunit -- ko00270 Cysteine and methionine metabolism ko00480 Glutathione metabolism ko01100 Metabolic pathways ko04216 Ferroptosis Glutamate-cysteine ligase regulatory subunit E Amino acid transport and metabolism ; IPR023210 [NADP-dependent oxidoreductase domain] -- -- P28667 MARCKS-related protein Marcksl1 1003.7 1075.1 773.7 565.2 618.4 625.3 1.57692520316214 0.0200383672161569 0.657114231728813 Significant up 1 Molecular Function:calmodulin binding (GO:0005516) MARCKS-related protein -- ko04666 Fc gamma R-mediated phagocytosis ko05140 Leishmaniasis -- -- -- IPR002101 [Myristoylated alanine-rich C-kinase substrate MARCKS] -- -- Q61398 Procollagen C-endopeptidase enhancer 1 Pcolce 770.7 726.5 703.4 777.1 749.8 732.7 0.973889183926359 0.451531491303688 -0.0381704733963159 Nonsignificant None -- -- -- -- -- -- -- -- IPR000859 [CUB domain] ; IPR018933[Netrin module, non-TIMP type] -- -- Q8K4L4 Protein POF1B Pof1b 2007.4 1845.4 2086.2 1984 1881.1 1988 1.01467598366677 0.735503711821099 0.021019105355657 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- A0A087WNZ7 E3 ubiquitin-protein ligase Trip12 1301 1285.7 1350.7 1367.1 1342.7 1322.2 0.976537698412698 0.251160663683046 -0.0342523556772434 Nonsignificant None 1 Molecular Function:ubiquitin-protein transferase activity (GO:0004842) E3 ubiquitin-protein ligase TRIP12 2.3.2.26 ko04120 Ubiquitin mediated proteolysis Putative ubiquitin fusion degradation protein O Posttranslational modification, protein turnover, chaperones ; IPR000569 [HECT domain] -- -- O35250 Exocyst complex component 7 Exoc7 1091.3 1106 1135.8 1219.7 1254.2 1229.2 0.900083713645324 0.00177198007393424 -0.15186890717345 Nonsignificant None 2 Cellular Component:exocyst (GO:0000145),Biological Process:exocytosis (GO:0006887) exocyst complex component 7 -- ko04910 Insulin signaling pathway Exocyst component protein and related proteins U Intracellular trafficking, secretion, and vesicular transport ; IPR004140 [Exocyst complex component Exo70] -- -- E0CXN5 Glycerol-3-phosphate dehydrogenase [NAD(+)] Gpd1 1676.8 1652.2 2003.5 2196.7 2304.8 2234.9 0.791594917166439 0.0163936167520107 -0.337165746021789 Nonsignificant None 5 Molecular Function:glycerol-3-phosphate dehydrogenase [NAD+] activity (GO:0004367),Biological Process:carbohydrate metabolic process (GO:0005975),Biological Process:glycerol-3-phosphate catabolic process (GO:0046168),Molecular Function:NAD binding (GO:0051287),Biological Process:oxidation-reduction process (GO:0055114) glycerol-3-phosphate dehydrogenase (NAD+) 1.1.1.8 ko00564 Glycerophospholipid metabolism Glycerol-3-phosphate dehydrogenase/dihydroxyacetone 3-phosphate reductase C Energy production and conversion ; IPR006109 [Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal] ; IPR011128[Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal] -- -- Q3TGS7 Sorting nexin-12 Snx12 1918.9 1747.9 1671.1 1744.8 1733.9 1896.3 0.993097674418605 0.89741372944018 -0.00999247635887088 Nonsignificant None 1 Molecular Function:phosphatidylinositol binding (GO:0035091) sorting nexin-3/12 -- ko04144 Endocytosis Sorting nexin SNX11 U Intracellular trafficking, secretion, and vesicular transport ; IPR001683 [Phox homologous domain] -- -- A0A1B0GSU0 Aldehyde dehydrogenase family 16 member A1 Aldh16a1 1687.5 1722.8 1863.1 1588.1 1614.8 1554.1 1.10855581248686 0.0380145525003405 0.148681407436613 Nonsignificant None 3 Biological Process:metabolic process (GO:0008152),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) -- -- -- Aldehyde dehydrogenase C Energy production and conversion ; IPR015590 [Aldehyde dehydrogenase domain] -- -- P53395 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial Dbt 3119.6 3008.6 3340.5 3944.4 3821 3966.5 0.807090070662041 0.00217442665894533 -0.30919840868749 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) 2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase) 2.3.1.168 ko00280 Valine, leucine and isoleucine degradation ko00640 Propanoate metabolism ko01100 Metabolic pathways Dihydrolipoamide transacylase (alpha-keto acid dehydrogenase E2 subunit) C Energy production and conversion ; IPR000089 [Biotin/lipoyl attachment] ; IPR001078[2-oxoacid dehydrogenase acyltransferase, catalytic domain] ; IPR004167[E3-binding domain] -- -- Q99JX3 Golgi reassembly-stacking protein 2 Gorasp2 1623.3 1552.4 1575.2 1552.1 1594 1571.6 1.00703732751129 0.670563784546943 0.0101171602238931 Nonsignificant None -- -- -- -- -- Golgi reassembly stacking protein GRASP65, contains PDZ domain U Intracellular trafficking, secretion, and vesicular transport ; IPR024958 [GRASP55/65 PDZ-like domain] -- -- Q9QZ88 Vacuolar protein sorting-associated protein 29 Vps29 534.8 551.3 799.5 799.9 813.1 806 0.779495659363373 0.173208010656913 -0.35938710561712 Nonsignificant None -- -- vacuolar protein sorting-associated protein 29 -- ko04144 Endocytosis Membrane coat complex Retromer, subunit VPS29/PEP11 U Intracellular trafficking, secretion, and vesicular transport ; IPR024654 [Calcineurin-like phosphoesterase domain, lpxH type] -- -- Q09199 Beta-1,4 N-acetylgalactosaminyltransferase 2 B4galnt2 2014.5 2022.8 3820.7 2188.3 2107.6 1999.7 1.24817332740327 0.477622441097948 0.319818287743562 Nonsignificant None -- -- beta-1,4-N-acetylgalactosaminyltransferase 2 2.4.1.- -- -- -- -- IPR001173 [Glycosyltransferase 2-like] -- -- J3QNM3 Protein enabled homolog Enah 2606.3 2778.5 2661.8 2505.6 2375.5 2274.5 1.12451786013751 0.0240694174132726 0.169306574879359 Nonsignificant None -- -- enabled -- ko04360 Axon guidance ko04810 Regulation of actin cytoskeleton Signal transduction protein Enabled, contains WH1 domain T Signal transduction mechanisms ; IPR000697 [WH1/EVH1 domain] ; IPR014885[VASP tetramerisation] -- -- Q6ZQI3 Malectin Mlec 2909.4 2759.6 2977.5 3084.5 3126.8 3107 0.927905304615649 0.0268204957358059 -0.107950513168369 Nonsignificant None -- -- -- -- -- Predicted receptor-like serine/threonine kinase T Signal transduction mechanisms ; IPR021720 [Malectin] -- -- P68181 cAMP-dependent protein kinase catalytic subunit beta Prkacb 698.5 720.4 765.2 832.8 790.5 904.4 0.86406614709024 0.041271316252752 -0.210786335246045 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) protein kinase A 2.7.11.11 ko01522 Endocrine resistance ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04020 Calcium signaling pathway ko04024 cAMP signaling pathway ko04062 Chemokine signaling pathway ko04114 Oocyte meiosis ko04140 Autophagy - animal ko04211 Longevity regulating pathway ko04213 Longevity regulating pathway - multiple species ko04261 Adrenergic signaling in cardiomyocytes ko04270 Vascular smooth muscle contraction ko04310 Wnt signaling pathway ko04340 Hedgehog signaling pathway ko04371 Apelin signaling pathway ko04530 Tight junction ko04540 Gap junction ko04611 Platelet activation ko04713 Circadian entrainment ko04720 Long-term potentiation ko04723 Retrograde endocannabinoid signaling ko04724 Glutamatergic synapse ko04725 Cholinergic synapse ko04726 Serotonergic synapse ko04727 GABAergic synapse ko04728 Dopaminergic synapse ko04740 Olfactory transduction ko04742 Taste transduction ko04750 Inflammatory mediator regulation of TRP channels ko04910 Insulin signaling pathway ko04911 Insulin secretion ko04912 GnRH signaling pathway ko04913 Ovarian steroidogenesis ko04914 Progesterone-mediated oocyte maturation ko04915 Estrogen signaling pathway ko04916 Melanogenesis ko04918 Thyroid hormone synthesis ko04919 Thyroid hormone signaling pathway ko04921 Oxytocin signaling pathway ko04922 Glucagon signaling pathway ko04923 Regulation of lipolysis in adipocytes ko04924 Renin secretion ko04925 Aldosterone synthesis and secretion ko04926 Relaxin signaling pathway ko04961 Endocrine and other factor-regulated calcium reabsorption ko04962 Vasopressin-regulated water reabsorption ko04970 Salivary secretion ko04971 Gastric acid secretion ko04976 Bile secretion ko05012 Parkinson's disease ko05020 Prion diseases ko05030 Cocaine addiction ko05031 Amphetamine addiction ko05032 Morphine addiction ko05146 Amoebiasis ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05205 Proteoglycans in cancer ko05414 Dilated cardiomyopathy (DCM) cAMP-dependent protein kinase catalytic subunit (PKA) T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q548F2 Guanine deaminase Gda 2886.6 3055.7 2783.3 2423.8 2748.6 2358.1 1.15870128145541 0.050999141821132 0.212508680831157 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) guanine deaminase 3.5.4.3 ko00230 Purine metabolism ko01100 Metabolic pathways Atrazine chlorohydrolase/guanine deaminase FQ Nucleotide transport and metabolism ; Secondary metabolites biosynthesis, transport and catabolism ; IPR006680 [Amidohydrolase-related] -- -- Q8BMJ3 Eukaryotic translation initiation factor 1A, X-chromosomal Eif1ax 1097.2 1036.5 825.1 829.8 811.1 924.1 1.15352826510721 0.216669119993404 0.206053355065895 Nonsignificant None 3 Molecular Function:RNA binding (GO:0003723),Molecular Function:translation initiation factor activity (GO:0003743),Biological Process:translational initiation (GO:0006413) translation initiation factor 1A -- ko03013 RNA transport Translation initiation factor 1A (eIF-1A) J Translation, ribosomal structure and biogenesis ; IPR006196 [RNA-binding domain, S1, IF1 type] -- -- Q8BP48 Methionine aminopeptidase 1 Metap1 383.2 354.9 370.9 337.7 336.7 346.9 1.08587094879076 0.0294531467829096 0.118852655073577 Nonsignificant None -- -- methionyl aminopeptidase 3.4.11.18 -- Putative methionine aminopeptidase O Posttranslational modification, protein turnover, chaperones ; IPR000994 [Peptidase M24] ; IPR031615[MYND-like zinc finger, mRNA-binding] -- -- Q9D358 Low molecular weight phosphotyrosine protein phosphatase Acp1 248 254.9 248.1 250.1 254.1 232 1.02010323281717 0.529353481670751 0.028715158017573 Nonsignificant None -- -- -- -- -- Protein tyrosine phosphatase T Signal transduction mechanisms ; IPR023485 [Phosphotyrosine protein phosphatase I superfamily] -- -- Q9D859 Uncharacterized protein Rac1 2136.5 2210.2 2316.7 2477.9 2566.8 2412.6 0.893540557574457 0.0183547909045743 -0.162394880580202 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related C3 botulinum toxin substrate 1 -- ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04024 cAMP signaling pathway ko04062 Chemokine signaling pathway ko04071 Sphingolipid signaling pathway ko04145 Phagosome ko04151 PI3K-Akt signaling pathway ko04310 Wnt signaling pathway ko04360 Axon guidance ko04370 VEGF signaling pathway ko04380 Osteoclast differentiation ko04510 Focal adhesion ko04520 Adherens junction ko04530 Tight junction ko04620 Toll-like receptor signaling pathway ko04650 Natural killer cell mediated cytotoxicity ko04662 B cell receptor signaling pathway ko04664 Fc epsilon RI signaling pathway ko04666 Fc gamma R-mediated phagocytosis ko04670 Leukocyte transendothelial migration ko04722 Neurotrophin signaling pathway ko04810 Regulation of actin cytoskeleton ko04932 Non-alcoholic fatty liver disease (NAFLD) ko04933 AGE-RAGE signaling pathway in diabetic complications ko04972 Pancreatic secretion ko05014 Amyotrophic lateral sclerosis (ALS) ko05100 Bacterial invasion of epithelial cells ko05132 Salmonella infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05205 Proteoglycans in cancer ko05210 Colorectal cancer ko05211 Renal cell carcinoma ko05212 Pancreatic cancer ko05231 Choline metabolism in cancer ko05416 Viral myocarditis ko05418 Fluid shear stress and atherosclerosis Ras-related small GTPase, Rho type R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- Q3TST0 Polyribonucleotide nucleotidyltransferase Pnpt1 3200.5 3011.6 3397.3 3633.4 3651.9 3643.2 0.879297250308825 0.0582395942967119 -0.185577137650209 Nonsignificant None 4 Molecular Function:3'-5'-exoribonuclease activity (GO:0000175),Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:RNA binding (GO:0003723),Biological Process:RNA processing (GO:0006396) polyribonucleotide nucleotidyltransferase 2.7.7.8 ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko03018 RNA degradation Predicted RNA-binding polyribonucleotide nucleotidyltransferase R General function prediction only ; IPR001247 [Exoribonuclease, phosphorolytic domain 1] ; IPR003029[S1 domain] ; IPR004088[K Homology domain, type 1] ; IPR015847[Exoribonuclease, phosphorolytic domain 2] ; IPR015848[Polyribonucleotide nucleotidyltransferase, RNA-binding domain] -- -- Q9D7N9 Adipocyte plasma membrane-associated protein Apmap 2176.5 2112.5 2333.2 2378 2321 2409.7 0.931562732989154 0.0829367714596075 -0.10227516895725 Nonsignificant None 2 Biological Process:biosynthetic process (GO:0009058),Molecular Function:strictosidine synthase activity (GO:0016844) adipocyte plasma membrane-associated protein -- -- Predicted alkaloid synthase/Surface mucin Hemomucin R General function prediction only ; IPR018119 [Strictosidine synthase, conserved region] -- -- Q3TR89 Conserved oligomeric Golgi complex subunit 1 Cog1 1193 1146.8 1060.5 1122 1153.3 1135.3 0.996980003518443 0.935521259214291 -0.00436352618574402 Nonsignificant None -- -- conserved oligomeric Golgi complex subunit 1 -- -- Low density lipoprotein B-like protein I Lipid transport and metabolism ; -- -- -- Q14C51 Pentatricopeptide repeat domain-containing protein 3, mitochondrial Ptcd3 1658.4 1469.5 1751.3 1764.8 1738.5 1788.6 0.922012887620703 0.177476166702434 -0.117141178531519 Nonsignificant None -- -- pentatricopeptide repeat domain-containing protein 3 -- -- Uncharacterized conserved protein S Function unknown ; IPR002885 [Pentatricopeptide repeat] -- -- Q9Z0P5 Twinfilin-2 Twf2 1009.8 1112.1 1202 1000.7 1069.4 1013.4 1.07796335333225 0.248614300653114 0.108308132761565 Nonsignificant None 2 Molecular Function:actin binding (GO:0003779),Cellular Component:intracellular (GO:0005622) twinfilin -- -- Protein tyrosine kinase 9/actin monomer-binding protein W Extracellular structures ; IPR002108 [Actin-depolymerising factor homology domain] -- -- Q8CFI7 DNA-directed RNA polymerase II subunit RPB2 Polr2b 1671.2 1684.9 1741.4 1692.9 1847.2 1817.5 0.951452142750485 0.170270512518042 -0.0717970029208339 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Molecular Function:DNA-directed 5'-3' RNA polymerase activity (GO:0003899) DNA-directed RNA polymerase II subunit RPB2 2.7.7.6 ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways ko03020 RNA polymerase ko05016 Huntington's disease ko05169 Epstein-Barr virus infection RNA polymerase II, second largest subunit K Transcription ; IPR007120 [DNA-directed RNA polymerase, subunit 2, domain 6] ; IPR007641[RNA polymerase Rpb2, domain 7] ; IPR007642[RNA polymerase Rpb2, domain 2] ; IPR007644[RNA polymerase, beta subunit, protrusion] ; IPR007645[RNA polymerase Rpb2, domain 3] ; IPR007646[RNA polymerase Rpb2, domain 4] ; IPR007647[RNA polymerase Rpb2, domain 5] -- -- Q921G9 Tight junction protein 3 Tjp3 1418 1345.5 1422.4 1377.5 1410.6 1319.5 1.01906222611744 0.513815304433653 0.0272421482359295 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) tight junction protein 3 -- ko04530 Tight junction Tight junction proteins T Signal transduction mechanisms ; IPR001478 [PDZ domain] ; IPR008145[Guanylate kinase/L-type calcium channel beta subunit] ; IPR011511[Variant SH3 domain] -- -- Q8K0C5 Zymogen granule membrane protein 16 Zg16 1930.8 1667.5 2234.6 3507.6 3494.2 3514.1 0.554674350269592 0.0107626444291928 -0.85028708223183 Significant down -- -- -- -- -- -- -- -- IPR001229 [Jacalin-like lectin domain] -- -- Q14C24 U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1 U2af1 2689.5 2810.9 1963.7 1738.1 1875.9 1898.9 1.35393350142393 0.0730902308882009 0.437156882545213 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:metal ion binding (GO:0046872) splicing factor U2AF 35 kDa subunit -- ko03040 Spliceosome U2 snRNP splicing factor, small subunit, and related proteins A RNA processing and modification ; IPR000504 [RNA recognition motif domain] ; IPR000571[Zinc finger, CCCH-type] -- -- Q3TJZ6 Protein FAM98A Fam98a 1325.6 1335.1 1202.9 1230.7 1304.6 1304.9 1.00609343263372 0.881739982539497 0.00876428977380696 Nonsignificant None -- -- -- -- -- Uncharacterized conserved glycine-rich protein S Function unknown ; IPR018797 [Uncharacterised protein family FAM98] -- -- Q9D666 SUN domain-containing protein 1 Sun1 1126.7 1228.6 1064.4 1200.2 1121.7 1221.2 0.965171742259603 0.507864109322466 -0.0511424171069182 Nonsignificant None -- -- SUN domain-containing protein 1/2 -- -- -- -- -- IPR012919 [SUN domain] ; IPR032680[SUN domain-containing protein 1, N-terminal] -- -- Q3TZS3 Integrin alpha-7 Itga7 1394.1 1396.3 1404.8 1736.1 1595.3 1688.9 0.835647272075374 0.0213373654505608 -0.259033987762758 Nonsignificant None -- -- integrin alpha 7 -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04810 Regulation of actin cytoskeleton ko05165 Human papillomavirus infection ko05410 Hypertrophic cardiomyopathy (HCM) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05414 Dilated cardiomyopathy (DCM) Vitronectin receptor, alpha subunit W Extracellular structures ; IPR013517 [FG-GAP repeat] ; IPR013649[Integrin alpha-2] -- -- Q5GLZ1 Cytochrome P450 2C65 Cyp2c65 1110.7 1148.9 3148.7 1590.6 1196.2 1316.1 1.31816520022423 0.558760559605286 0.398531188713906 Nonsignificant None 3 Molecular Function:iron ion binding (GO:0005506),Molecular Function:heme binding (GO:0020037),Biological Process:oxidation-reduction process (GO:0055114) cytochrome P450 family 2 subfamily C 1.14.14.1 ko00140 Steroid hormone biosynthesis ko00590 Arachidonic acid metabolism ko00591 Linoleic acid metabolism ko00830 Retinol metabolism ko01100 Metabolic pathways ko04726 Serotonergic synapse ko04750 Inflammatory mediator regulation of TRP channels ko05204 Chemical carcinogenesis Cytochrome P450 CYP2 subfamily Q Secondary metabolites biosynthesis, transport and catabolism ; IPR001128 [Cytochrome P450] -- -- Q3UNI8 D-dopachrome tautomerase Ddt 1824.7 1674.3 1726 1948.6 1902.8 2054.9 0.884648595567445 0.0227252336777892 -0.176823600267207 Nonsignificant None -- -- D-dopachrome decarboxylase 4.1.1.84 -- Macrophage migration inhibitory factor V Defense mechanisms ; IPR001398 [Macrophage migration inhibitory factor] -- -- Q8BKY2 Uncharacterized protein Col3a1 2428.6 2587.4 3108.6 3144.7 3099.9 2707.8 0.907533175461329 0.327996512551372 -0.139977712166067 Nonsignificant None 2 Molecular Function:extracellular matrix structural constituent (GO:0005201),Molecular Function:protein binding (GO:0005515) collagen, type III, alpha -- ko04611 Platelet activation ko04926 Relaxin signaling pathway ko04933 AGE-RAGE signaling pathway in diabetic complications ko04974 Protein digestion and absorption ko05146 Amoebiasis Collagens (type IV and type XIII), and related proteins W Extracellular structures ; IPR000885 [Fibrillar collagen, C-terminal] ; IPR001007[VWFC domain] ; IPR008160[Collagen triple helix repeat] -- -- Q3UK67 Splicing factor 1 Sf1 3440.1 3345.6 3459.7 3167.5 3269.9 3163.9 1.0670846656182 0.0122609129167503 0.0936746483475694 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:RNA binding (GO:0003723),Molecular Function:zinc ion binding (GO:0008270) splicing factor 1 -- -- Splicing factor 1/branch point binding protein (RRM superfamily) A RNA processing and modification ; IPR001878 [Zinc finger, CCHC-type] ; IPR004088[K Homology domain, type 1] ; IPR032570[Splicing factor 1, helix-hairpin domain] -- -- H3BKL6 Melanoma inhibitory activity protein 2 Mia2 1328.1 1271.9 1313 1483.9 1433.2 1390.6 0.908373377904682 0.0143593252161374 -0.138642669916649 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q8CAQ5 Uncharacterized protein 55.2 59.2 74.5 74.5 79.7 73 0.831426056338028 0.109444554804081 -0.266340133116312 Nonsignificant None -- -- prothymosin alpha -- ko05169 Epstein-Barr virus infection -- -- -- IPR004931 [Prothymosin/parathymosin] -- -- Q544U5 Uncharacterized protein Entpd1 740.8 787.5 786.9 934 944.3 982.3 0.809340697755716 0.00103967812279661 -0.305180951573222 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) apyrase 3.6.1.5 ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko05169 Epstein-Barr virus infection Nucleoside phosphatase F Nucleotide transport and metabolism ; IPR000407 [Nucleoside phosphatase GDA1/CD39] -- -- Q91WS0 CDGSH iron-sulfur domain-containing protein 1 Cisd1 2162.8 2311.9 2570.3 3068 2923.1 3003.8 0.783221603353011 0.00674359723631867 -0.352507535997317 Nonsignificant None 1 Cellular Component:intracellular membrane-bounded organelle (GO:0043231) -- -- -- CDGSH-type Zn-finger containing protein R General function prediction only ; IPR018967 [Iron sulphur-containing domain, CDGSH-type] ; IPR019610[Iron sulphur domain-containing, mitoNEET, N-terminal] -- -- Q91X95 Guanine nucleotide binding protein, alpha 11 Gna11 1432 1604.4 2031 2122.6 2204.9 1842 0.82136315746819 0.153914605836513 -0.283907858709918 Nonsignificant None 5 Molecular Function:GTPase activity (GO:0003924),Molecular Function:signal transducer activity (GO:0004871),Biological Process:G-protein coupled receptor signaling pathway (GO:0007186),Molecular Function:guanyl nucleotide binding (GO:0019001),Molecular Function:G-protein beta/gamma-subunit complex binding (GO:0031683) guanine nucleotide-binding protein subunit alpha-11 -- ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04270 Vascular smooth muscle contraction ko04540 Gap junction ko04725 Cholinergic synapse ko04730 Long-term depression ko04911 Insulin secretion ko04912 GnRH signaling pathway ko04925 Aldosterone synthesis and secretion ko05142 Chagas disease (American trypanosomiasis) ko05146 Amoebiasis ko05200 Pathways in cancer G protein subunit Galphaq/Galphay, small G protein superfamily T Signal transduction mechanisms ; IPR001019 [Guanine nucleotide binding protein (G-protein), alpha subunit] -- -- A0A0A6YWM5 Rab3 GTPase-activating protein non-catalytic subunit Rab3gap2 2221.8 2270.9 2236.2 2195.4 2160.4 2156.1 1.03332360754926 0.0195273737614805 0.0472921359978831 Nonsignificant None -- -- Rab3 GTPase-activating protein non-catalytic subunit -- -- Rab3 GTPase-activating protein, non-catalytic subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR029257 [Rab3GAP regulatory subunit, C-terminal] ; IPR032839[Rab3-GAP regulatory subunit, N-terminal] -- -- Q3TDN8 AB hydrolase-1 domain-containing protein Bphl 2072 2225.2 2636.5 3181.1 3056.1 3042.6 0.747182051337313 0.0109140771649392 -0.42046829556471 Nonsignificant None -- -- valacyclovir hydrolase 3.1.-.- -- Predicted hydrolase R General function prediction only ; IPR000073 [Alpha/beta hydrolase fold-1] -- -- Q8R326 Paraspeckle component 1 Pspc1 3106.4 3102 3112.1 2987 2836.2 3091.2 1.04555550569864 0.208777973065267 0.0642696527171454 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- RNA-binding protein p54nrb (RRM superfamily) A RNA processing and modification ; IPR000504 [RNA recognition motif domain] ; IPR012975[NOPS] -- -- Q641N3 Rps16 protein (Fragment) Rps16 5632.1 5466.7 4349.4 3499.5 3430.2 3657 1.45920825186319 0.0165660785288899 0.545185793118881 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S16e -- ko03010 Ribosome 40S ribosomal protein S16 J Translation, ribosomal structure and biogenesis ; IPR000754 [Ribosomal protein S9] -- -- B2RXW7 Complement component 4B (Childo blood group) C4b 628.1 626.2 455.3 442.7 464.6 452.1 1.25761365308224 0.17703742050511 0.330688785183015 Nonsignificant None 3 Molecular Function:endopeptidase inhibitor activity (GO:0004866),Cellular Component:extracellular region (GO:0005576),Cellular Component:extracellular space (GO:0005615) complement component 4 -- ko04610 Complement and coagulation cascades ko05133 Pertussis ko05150 Staphylococcus aureus infection ko05322 Systemic lupus erythematosus Alpha-macroglobulin O Posttranslational modification, protein turnover, chaperones ; IPR000020 [Anaphylatoxin/fibulin] ; IPR001599[Alpha-2-macroglobulin] ; IPR002890[Alpha-2-macroglobulin, N-terminal] ; IPR009048[Alpha-macroglobulin, receptor-binding] ; IPR011625[Alpha-2-macroglobulin, N-terminal 2] ; IPR011626[Alpha-macroglobulin complement component] ; IPR018933[Netrin module, non-TIMP type] ; IPR019565[Alpha-2-macroglobulin, thiol-ester bond-forming] -- -- P20444 Protein kinase C alpha type Prkca 2275.1 2231.5 3090.2 2625.5 2472.8 2680.8 0.976565412451312 0.842178824504432 -0.034211412722567 Nonsignificant None 6 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468),Biological Process:intracellular signal transduction (GO:0035556) classical protein kinase C alpha type 2.7.11.13 ko01521 EGFR tyrosine kinase inhibitor resistance ko04010 MAPK signaling pathway ko04012 ErbB signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04020 Calcium signaling pathway ko04066 HIF-1 signaling pathway ko04070 Phosphatidylinositol signaling system ko04071 Sphingolipid signaling pathway ko04072 Phospholipase D signaling pathway ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04261 Adrenergic signaling in cardiomyocytes ko04270 Vascular smooth muscle contraction ko04310 Wnt signaling pathway ko04360 Axon guidance ko04370 VEGF signaling pathway ko04510 Focal adhesion ko04540 Gap junction ko04650 Natural killer cell mediated cytotoxicity ko04664 Fc epsilon RI signaling pathway ko04666 Fc gamma R-mediated phagocytosis ko04670 Leukocyte transendothelial migration ko04713 Circadian entrainment ko04720 Long-term potentiation ko04723 Retrograde endocannabinoid signaling ko04724 Glutamatergic synapse ko04725 Cholinergic synapse ko04726 Serotonergic synapse ko04727 GABAergic synapse ko04728 Dopaminergic synapse ko04730 Long-term depression ko04750 Inflammatory mediator regulation of TRP channels ko04911 Insulin secretion ko04912 GnRH signaling pathway ko04916 Melanogenesis ko04918 Thyroid hormone synthesis ko04919 Thyroid hormone signaling pathway ko04921 Oxytocin signaling pathway ko04925 Aldosterone synthesis and secretion ko04926 Relaxin signaling pathway ko04933 AGE-RAGE signaling pathway in diabetic complications ko04960 Aldosterone-regulated sodium reabsorption ko04961 Endocrine and other factor-regulated calcium reabsorption ko04970 Salivary secretion ko04971 Gastric acid secretion ko04972 Pancreatic secretion ko05031 Amphetamine addiction ko05032 Morphine addiction ko05143 African trypanosomiasis ko05146 Amoebiasis ko05161 Hepatitis B ko05164 Influenza A ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05206 MicroRNAs in cancer ko05214 Glioma ko05223 Non-small cell lung cancer ko05225 Hepatocellular carcinoma ko05231 Choline metabolism in cancer Serine/threonine protein kinase T Signal transduction mechanisms ; IPR000008 [C2 domain] ; IPR000719[Protein kinase domain] ; IPR002219[Protein kinase C-like, phorbol ester/diacylglycerol-binding domain] ; IPR017892[Protein kinase, C-terminal] -- -- E9PYK3 Protein mono-ADP-ribosyltransferase PARP4 Parp4 1365.1 1308.7 1644.7 1315.4 1333.3 1292.1 1.09584348355664 0.349047931976071 0.132041756672992 Nonsignificant None 1 Molecular Function:NAD+ ADP-ribosyltransferase activity (GO:0003950) poly [ADP-ribose] polymerase 2.4.2.30 ko03410 Base excision repair ko04210 Apoptosis ko04217 Necroptosis -- -- -- IPR001357 [BRCT domain] ; IPR002035[von Willebrand factor, type A] ; IPR009408[Formin Homology 1] ; IPR012317[Poly(ADP-ribose) polymerase, catalytic domain] ; IPR013694[VIT domain] -- -- A0A1B0GS68 60S ribosomal protein L13a Gm45713 7265.6 6868.9 6031.7 5503.4 5436 5601.9 1.21914238905044 0.0774358768117072 0.285866634555571 Nonsignificant None 5 Molecular Function:structural constituent of ribosome (GO:0003735),Molecular Function:cytokine activity (GO:0005125),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412),Cellular Component:membrane (GO:0016020) fms-related tyrosine kinase 3 ligand -- ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04060 Cytokine-cytokine receptor interaction ko04151 PI3K-Akt signaling pathway ko04640 Hematopoietic cell lineage ko05200 Pathways in cancer 60S ribosomal protein L13a J Translation, ribosomal structure and biogenesis ; IPR004213 [Flt3 ligand] ; IPR005822[Ribosomal protein L13] -- -- Q4FJR9 G1p2 protein Isg15 768.4 690.6 723.7 1096 1372.5 1358.6 0.570327401949257 0.00409929572769498 -0.810137744791358 Significant down 1 Molecular Function:protein binding (GO:0005515) ubiquitin cross-reactive protein -- ko04622 RIG-I-like receptor signaling pathway ko05165 Human papillomavirus infection Ubiquitin and ubiquitin-like proteins OR Posttranslational modification, protein turnover, chaperones ; General function prediction only ; IPR000626 [Ubiquitin domain] -- -- Q3TQC7 Ectonucleoside triphosphate diphosphohydrolase 5 Entpd5 2064.1 2123.3 1795.2 1977.7 1907 2108.4 0.99824798518296 0.977554730836579 -0.00252983989428801 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) ectonucleoside triphosphate diphosphohydrolase 5/6 3.6.1.6 ko00230 Purine metabolism ko00240 Pyrimidine metabolism Nucleoside phosphatase F Nucleotide transport and metabolism ; IPR000407 [Nucleoside phosphatase GDA1/CD39] -- -- O08582 GTP-binding protein 1 Gtpbp1 1086.7 1101.1 1183.9 1180.5 1193.3 1225.3 0.936817537717763 0.0837735191760973 -0.0941600107843424 Nonsignificant None -- -- -- -- -- GTP-binding protein GP-1 R General function prediction only ; -- -- -- Q3UDI2 Protein kinase domain-containing protein Map2k3 1609.6 1629 1236.4 1187 1220.3 1232.1 1.22959828543166 0.159643642920925 0.298187058429416 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) mitogen-activated protein kinase kinase 3 2.7.12.2 ko04010 MAPK signaling pathway ko04015 Rap1 signaling pathway ko04218 Cellular senescence ko04620 Toll-like receptor signaling pathway ko04664 Fc epsilon RI signaling pathway ko04668 TNF signaling pathway ko04750 Inflammatory mediator regulation of TRP channels ko04912 GnRH signaling pathway ko05014 Amyotrophic lateral sclerosis (ALS) ko05145 Toxoplasmosis ko05164 Influenza A ko05169 Epstein-Barr virus infection Mitogen-activated protein kinase (MAPK) kinase MKK3/MKK6 T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q8VCF1 Soluble calcium-activated nucleotidase 1 Cant1 1849.1 1754.5 1985.9 2139.7 2183 2197 0.857324723530224 0.0110644807996023 -0.22208634644871 Nonsignificant None 2 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:nucleoside-diphosphatase activity (GO:0017110) soluble calcium-activated nucleotidase 1 3.6.1.6 ko00230 Purine metabolism ko00240 Pyrimidine metabolism Cell surface ATP diphosphohydrolase Apyrase F Nucleotide transport and metabolism ; IPR009283 [Apyrase] -- -- Q3ULD5 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial Mccc2 1183.2 1197.7 1244.6 1502 1426.4 1310.4 0.85531282438426 0.0253156909587899 -0.225475923255981 Nonsignificant None -- -- 3-methylcrotonyl-CoA carboxylase beta subunit 6.4.1.4 ko00280 Valine, leucine and isoleucine degradation ko01100 Metabolic pathways 3-Methylcrotonyl-CoA carboxylase, non-biotin containing subunit/Acetyl-CoA carboxylase carboxyl transferase, subunit beta EI Amino acid transport and metabolism ; Lipid transport and metabolism ; IPR000022 [Carboxyl transferase] -- -- P70670 Nascent polypeptide-associated complex subunit alpha, muscle-specific form Naca 1944.2 1893.4 1872.2 1580.6 1656.6 1646.3 1.16920241629978 0.00099932909841497 0.225524715765426 Nonsignificant None -- -- nascent polypeptide-associated complex subunit alpha -- -- Transcription factor containing NAC and TS-N domains K Transcription ; IPR002715 [Nascent polypeptide-associated complex NAC domain] -- -- P36916 Guanine nucleotide-binding protein-like 1 Gnl1 842.2 877.1 842.4 901.8 874.2 906.7 0.954896186677601 0.0587687432156953 -0.0665841984996289 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) -- -- -- Predicted GTP-binding protein MMR1 R General function prediction only ; IPR006073 [GTP binding domain] -- -- Q3UG90 Paxillin Pxn 1699.7 1701.5 1588.6 1576.3 1598.1 1619.9 1.04077759005486 0.173486304222653 0.0576618035011732 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) paxillin -- ko04062 Chemokine signaling pathway ko04370 VEGF signaling pathway ko04510 Focal adhesion ko04670 Leukocyte transendothelial migration ko04810 Regulation of actin cytoskeleton ko05100 Bacterial invasion of epithelial cells ko05165 Human papillomavirus infection ko05203 Viral carcinogenesis ko05205 Proteoglycans in cancer Adaptor protein Enigma and related PDZ-LIM proteins TZ Signal transduction mechanisms ; Cytoskeleton ; IPR001781 [Zinc finger, LIM-type] -- -- O55142 60S ribosomal protein L35a Rpl35a 9467.3 8868.3 5765.7 5347.9 5676.3 5253.7 1.48061482132216 0.149282551484261 0.566196375506187 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L35Ae -- ko03010 Ribosome 60S ribosomal protein L35A/L37 J Translation, ribosomal structure and biogenesis ; IPR001780 [Ribosomal protein L35A] -- -- Q3UHU8 General transcription factor II-I Gtf2i 2413 2415.9 2667.9 2452.1 2523.6 2480.4 1.00545861777605 0.883644770852978 0.00785370505664043 Nonsignificant None -- -- transcription initiation factor TFII-I -- ko03022 Basal transcription factors ko04022 cGMP-PKG signaling pathway ko05168 Herpes simplex infection -- -- -- IPR004212 [GTF2I-like repeat] -- GTF2I P47758 Signal recognition particle receptor subunit beta Srprb 1791.6 1749.7 2013.7 1890.8 1958.7 1860.8 0.972803530462498 0.583370631163882 -0.0397796303210213 Nonsignificant None -- -- signal recognition particle receptor subunit beta -- ko03060 Protein export Signal recognition particle receptor, beta subunit (small G protein superfamily) U Intracellular trafficking, secretion, and vesicular transport ; IPR019009 [Signal recognition particle receptor, beta subunit] -- -- Q9CX34 Protein SGT1 homolog Sugt1 2238.2 2378 2519.2 2255.5 2385.2 2230.5 1.03845034346257 0.402900251172511 0.0544322311531021 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) suppressor of G2 allele of SKP1 -- ko04621 NOD-like receptor signaling pathway Suppressor of G2 allele of skp1 T Signal transduction mechanisms ; IPR007052 [CS domain] ; IPR007699[SGS domain] ; IPR019734[Tetratricopeptide repeat] -- -- Q8BHB9 Chloride intracellular channel protein 6 Clic6 748.9 710.1 814.4 880.5 955.5 970.8 0.809961522017956 0.0125843553895866 -0.304074721843719 Nonsignificant None -- -- chloride intracellular channel protein 6 -- -- Intracellular Cl- channel CLIC, contains GST domain P Inorganic ion transport and metabolism ; -- -- -- Q3UIA4 Aldehyde dehydrogenase Aldh1a3 1237.1 1589.3 686.1 490.1 577.4 495.2 2.24771229282652 0.13034750157416 1.16845738241115 Nonsignificant None 3 Biological Process:metabolic process (GO:0008152),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) aldehyde dehydrogenase (NAD(P)+) 1.2.1.5 ko00010 Glycolysis / Gluconeogenesis ko00340 Histidine metabolism ko00350 Tyrosine metabolism ko00360 Phenylalanine metabolism ko00410 beta-Alanine metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko01100 Metabolic pathways ko05204 Chemical carcinogenesis Aldehyde dehydrogenase C Energy production and conversion ; IPR015590 [Aldehyde dehydrogenase domain] -- -- Q61781 Keratin, type I cytoskeletal 14 Krt14 544.7 584.8 268.7 228 206.3 194.7 2.22289348171701 0.121705347037423 1.15243881787435 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) type I keratin, acidic -- -- -- -- -- IPR001664 [Intermediate filament protein] -- -- Q4LDD4 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 Arap1 898.5 926.1 811.3 994 954.8 1008.9 0.891199242654766 0.0483186068714144 -0.166180088217809 Nonsignificant None 3 Molecular Function:GTPase activator activity (GO:0005096),Molecular Function:protein binding (GO:0005515),Biological Process:signal transduction (GO:0007165) Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 -- ko04144 Endocytosis Rho- and Arf-GTPase activating protein ARAP3 TZ Signal transduction mechanisms ; Cytoskeleton ; IPR000159 [Ras-associating (RA) domain] ; IPR000198[Rho GTPase-activating protein domain] ; IPR001164[Arf GTPase activating protein] ; IPR001660[Sterile alpha motif domain] ; IPR001849[Pleckstrin homology domain] -- -- P62075 Mitochondrial import inner membrane translocase subunit Tim13 Timm13 2372.4 2225.1 2403.3 2503.4 2417.1 2591.5 0.931948881789137 0.0842469721452891 -0.101677270921803 Nonsignificant None -- -- mitochondrial import inner membrane translocase subunit TIM13 -- -- Mitochondrial import inner membrane translocase, subunit TIM13 U Intracellular trafficking, secretion, and vesicular transport ; IPR004217 [Tim10/DDP family zinc finger] -- -- Q3UYN1 Pyridoxal phosphate homeostasis protein Plpbp 1919.4 1946.3 1915.9 2238.4 2277.4 2132.6 0.869622766379881 0.00285620174426554 -0.201538384842499 Nonsignificant None -- -- PLP dependent protein -- -- Proline synthetase co-transcribed protein R General function prediction only ; IPR001608 [Alanine racemase, N-terminal] -- -- A2AUD5 Tumor protein D54 Tpd52l2 3639.1 3633.1 3460.5 3177.3 3222.6 3310.2 1.10531302458265 0.0083726272726905 0.144454998630845 Nonsignificant None -- -- -- -- -- Coiled-coil protein TPD52 R General function prediction only ; IPR007327 [Tumour protein D52] -- -- Q91Z40 Guanylate-binding protein 7 Gbp7 1594.2 1942 1894.4 1724.3 1799.2 1694.3 1.04078347196136 0.565062121647767 0.0576699568025608 Nonsignificant None 2 Molecular Function:GTPase activity (GO:0003924),Molecular Function:GTP binding (GO:0005525) guanylate-binding protein 1/3/4/7 -- ko04621 NOD-like receptor signaling pathway Guanylate-binding protein R General function prediction only ; IPR003191 [Guanylate-binding protein, C-terminal] ; IPR015894[Guanylate-binding protein, N-terminal] -- -- P56391 Cytochrome c oxidase subunit 6B1 Cox6b1 3076.7 3050.6 3961.7 4366.3 4184.8 4208.5 0.790698767986457 0.0432234015839988 -0.338799918145742 Nonsignificant None 2 Molecular Function:cytochrome-c oxidase activity (GO:0004129),Cellular Component:mitochondrion (GO:0005739) cytochrome c oxidase subunit 6b -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04260 Cardiac muscle contraction ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Cytochrome c oxidase, subunit VIb/COX12 C Energy production and conversion ; IPR003213 [Cytochrome c oxidase, subunit VIb] -- -- A0A286YDA2 Nucleolar and coiled-body phosphoprotein 1 Nolc1 1893.6 1954 1615 1453 1371.9 1439.8 1.28088728398246 0.0205001875930838 0.35714352642566 Nonsignificant None -- -- -- -- -- Nucleolar GTPase/ATPase p130 Y Nuclear structure ; IPR007718 [SRP40, C-terminal] -- -- A0A140LHA2 Mitotic checkpoint protein BUB3 Bub3 2572.5 2538.8 2785.5 2595.8 2555.4 2678.3 1.00859569576601 0.805502335705734 0.0123479736457507 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) cell cycle arrest protein BUB3 -- ko04110 Cell cycle ko05166 HTLV-I infection Mitotic spindle checkpoint protein BUB3, WD repeat superfamily D Cell cycle control, cell division, chromosome partitioning ; IPR001680 [WD40 repeat] -- -- Q540N6 Neuronal apoptosis inhibitory protein 2 Naip2 894.4 877.7 763 774 747.4 745.4 1.11836068466561 0.102086800811477 0.161385549593041 Nonsignificant None -- -- baculoviral IAP repeat-containing protein 1 -- ko04621 NOD-like receptor signaling pathway ko05134 Legionellosis -- -- -- IPR001370 [BIR repeat] -- -- Q9Z247 Peptidyl-prolyl cis-trans isomerase FKBP9 Fkbp9 2054 2090.9 2332.1 1853.3 2226.6 2083.6 1.05086395716719 0.495116124445675 0.0715759128548491 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) FK506-binding protein 9/10 5.2.1.8 -- FKBP-type peptidyl-prolyl cis-trans isomerase O Posttranslational modification, protein turnover, chaperones ; IPR001179 [FKBP-type peptidyl-prolyl cis-trans isomerase domain] ; IPR002048[EF-hand domain] -- -- Q9Z0W3 Nuclear pore complex protein Nup160 Nup160 1506.1 1466.1 1373.5 1245.6 1313.8 1311.4 1.12268781647205 0.024813615550669 0.166956816215156 Nonsignificant None -- -- nuclear pore complex protein Nup160 -- ko03013 RNA transport Nuclear pore complex, Nup160 component YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; -- -- -- Q5EBI8 ATP synthase subunit e, mitochondrial Atp5k 3614.6 3477.5 3525.4 3994.8 4000.8 3843.5 0.896816480982507 0.00336658434485162 -0.157115303794365 Nonsignificant None 2 Molecular Function:hydrogen ion transmembrane transporter activity (GO:0015078),Biological Process:ATP synthesis coupled proton transport (GO:0015986) F-type H+-transporting ATPase subunit e -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways Mitochondrial F1F0-ATP synthase, subunit e C Energy production and conversion ; IPR008386 [ATP synthase, F0 complex, subunit E, mitochondrial] -- -- F6ZS70 Non-specific serine/threonine protein kinase (Fragment) Mark2 1180.8 1195.2 1050.4 1100.5 1104 1098.2 1.03745420413601 0.465138135311804 0.0530476536411651 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) MAP/microtubule affinity-regulating kinase 2.7.11.1 -- Serine/threonine protein kinase R General function prediction only ; IPR000719 [Protein kinase domain] ; IPR001772[Kinase associated domain 1 (KA1)] ; IPR015940[Ubiquitin-associated domain] -- -- P61327 Protein mago nashi homolog Magoh 3469 3515.5 3860.6 3539.3 3539.5 3626.9 1.01302110090886 0.73280854510519 0.0186642253330495 Nonsignificant None 1 Cellular Component:nucleus (GO:0005634) protein mago nashi -- ko03013 RNA transport ko03015 mRNA surveillance pathway ko03040 Spliceosome Exon-exon junction complex, Magoh component A RNA processing and modification ; IPR004023 [Mago nashi protein] -- -- Q60902 Epidermal growth factor receptor substrate 15-like 1 Eps15l1 1526.1 1482 1578.5 1538.5 1564.2 1617.5 0.971696114571416 0.287398744658926 -0.0414228947886447 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) epidermal growth factor receptor substrate 15 -- ko04144 Endocytosis Synaptic vesicle protein EHS-1 and related EH domain proteins TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR000261 [EH domain] -- -- Q8BSZ5 Uncharacterized protein Ctss 1867.4 1882 1568.3 2319.4 2176.6 2169.7 0.797770676748128 0.0165800547507978 -0.325953998897146 Nonsignificant None 2 Biological Process:proteolysis (GO:0006508),Molecular Function:cysteine-type peptidase activity (GO:0008234) cathepsin S 3.4.22.27 ko04142 Lysosome ko04145 Phagosome ko04210 Apoptosis ko04612 Antigen processing and presentation ko05152 Tuberculosis Cysteine proteinase Cathepsin L O Posttranslational modification, protein turnover, chaperones ; IPR000668 [Peptidase C1A, papain C-terminal] ; IPR013201[Cathepsin propeptide inhibitor domain (I29)] -- -- Q922N9 Trim25 protein Trim25 1313.2 1294.2 1397.1 1529.9 1519.1 1452.5 0.889592358102855 0.0141325489995422 -0.168783700007674 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) tripartite motif-containing protein 25 2.3.2.27 ko04064 NF-kappa B signaling pathway ko04622 RIG-I-like receptor signaling pathway ko05164 Influenza A Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR003877 [SPRY domain] ; IPR006574[SPRY-associated] -- -- A0A6Q6PUT5 Pre-mRNA-processing factor 40 homolog A (Fragment) Prpf40a 2621.3 2598.7 2723.1 2722.2 2852.4 2618.8 0.969451021553934 0.34316321061942 -0.0447600823172143 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) pre-mRNA-processing factor 40 -- ko03040 Spliceosome Spliceosomal protein FBP11/Splicing factor PRP40 A RNA processing and modification ; IPR001202 [WW domain] ; IPR002713[FF domain] -- -- Q8CAQ1 Uncharacterized protein Mbnl1 39.3 29.3 20.9 26.3 24.8 26.2 1.15782664941785 0.524770510922994 0.211419268226772 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) muscleblind -- -- C3H1-type Zn-finger protein K Transcription ; IPR000571 [Zinc finger, CCCH-type] -- -- Q9Z2W1 Serine/threonine-protein kinase 25 Stk25 509.3 495.7 593.5 549.7 591.2 522.8 0.960810242231172 0.58348103458311 -0.0576765646417335 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) serine/threonine-protein kinase 24/25/MST4 2.7.11.1 -- Serine/threonine protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q9JLV5 Cullin-3 Cul3 2739.4 2766.2 2647 2592.5 2468.6 2707.1 1.04948379289926 0.174725730678575 0.0696798873690743 Nonsignificant None 2 Biological Process:ubiquitin-dependent protein catabolic process (GO:0006511),Molecular Function:ubiquitin protein ligase binding (GO:0031625) cullin 3 -- ko04120 Ubiquitin mediated proteolysis ko04340 Hedgehog signaling pathway Cullins D Cell cycle control, cell division, chromosome partitioning ; IPR001373 [Cullin, N-terminal] ; IPR019559[Cullin protein, neddylation domain] -- -- Q3TV90 Uncharacterized protein (Fragment) Luc7l 439.3 521.3 495.9 468.9 458.5 406.2 1.09215656868626 0.257422324051489 0.127179692041294 Nonsignificant None 3 Molecular Function:mRNA binding (GO:0003729),Cellular Component:U1 snRNP (GO:0005685),Biological Process:mRNA splice site selection (GO:0006376) -- -- -- Spliceosome subunit A RNA processing and modification ; IPR004882 [Luc7-related] -- -- Q78IK4 MICOS complex subunit Mic27 Apool 1485.5 1531.2 2037.8 2119.3 2050 2161.8 0.798360474483107 0.077263163630416 -0.324887797908019 Nonsignificant None 2 Biological Process:cristae formation (GO:0042407),Cellular Component:MICOS complex (GO:0061617) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019166 [MICOS complex subunit MIC26/MIC27] -- -- Q8C952 Flap endonuclease 1 Fen1 2141.2 2178.7 2278 1805.5 1943.4 1874.8 1.17323114675392 0.00469394780935399 0.23048727715444 Nonsignificant None 2 Molecular Function:nuclease activity (GO:0004518),Biological Process:DNA repair (GO:0006281) flap endonuclease-1 3.-.-.- ko03030 DNA replication ko03410 Base excision repair ko03450 Non-homologous end-joining 5'-3' exonuclease L Replication, recombination and repair ; IPR006085 [XPG N-terminal] ; IPR006086[XPG-I domain] -- -- Q3UC67 Long-chain-fatty-acid--CoA ligase Acsl5 1514.2 1402.1 1575.2 1505.1 1498.3 1478.9 1.00205251768066 0.957541337854489 0.00295812231747991 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) long-chain acyl-CoA synthetase 6.2.1.3 ko00061 Fatty acid biosynthesis ko00071 Fatty acid degradation ko01100 Metabolic pathways ko01212 Fatty acid metabolism ko03320 PPAR signaling pathway ko04146 Peroxisome ko04216 Ferroptosis ko04920 Adipocytokine signaling pathway Long-chain acyl-CoA synthetases (AMP-forming) I Lipid transport and metabolism ; IPR000873 [AMP-dependent synthetase/ligase] -- -- Q6IFX2 Keratin, type I cytoskeletal 42 Krt42 466.4 499.6 368.4 633.2 758.3 606.6 0.667834442720585 0.0223898688327478 -0.5824375943872 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) type I keratin, acidic -- -- -- -- -- IPR001664 [Intermediate filament protein] -- -- Q3UNC0 NTP_transferase domain-containing protein (Fragment) Gmppa 1702 1689.7 1765.8 2094.9 2062.1 1924 0.848133530669298 0.00584565171978367 -0.237636673414208 Nonsignificant None 2 Biological Process:biosynthetic process (GO:0009058),Molecular Function:nucleotidyltransferase activity (GO:0016779) mannose-1-phosphate guanylyltransferase 2.7.7.13 ko00051 Fructose and mannose metabolism ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways GDP-mannose pyrophosphorylase GMO Carbohydrate transport and metabolism ; Cell wall/membrane/envelope biogenesis ; Posttranslational modification, protein turnover, chaperones ; IPR001451 [Hexapeptide repeat] ; IPR005835[Nucleotidyl transferase domain] -- -- Q8CG76 Aflatoxin B1 aldehyde reductase member 2 Akr7a2 1603.2 1570.7 1820.2 1903.2 1863 2087 0.853225586004237 0.0516655102643109 -0.229000865908404 Nonsignificant None -- -- aflatoxin B1 aldehyde reductase -- ko00980 Metabolism of xenobiotics by cytochrome P450 -- -- -- IPR023210 [NADP-dependent oxidoreductase domain] -- -- Q6PHQ8 N-alpha-acetyltransferase 35, NatC auxiliary subunit Naa35 1473.3 1411.4 1482.3 1467.4 1514.7 1514.9 0.97109183900378 0.187868221884571 -0.0423203528887606 Nonsignificant None -- -- N-alpha-acetyltransferase 35, NatC auxiliary subunit -- -- Glucose-repressible protein and related proteins R General function prediction only ; IPR007244 [NatC N(alpha)-terminal acetyltransferase, Mak10 subunit] -- -- D3Z4J9 Echinoderm microtubule-associated protein-like 1 Eml1 2496.5 2526.6 3071.5 3153.2 3158.4 3038.9 0.865686326934388 0.0933581165540018 -0.208083721843077 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) echinoderm microtubule-associated protein-like 1/2 -- -- Uncharacterized conserved protein, contains HELP and WD40 domains S Function unknown ; IPR001680 [WD40 repeat] ; IPR005108[HELP] -- -- A0A0R4J0D3 Dolichyl-diphosphooligosaccharide--protein glycotransferase Stt3b 1682.5 1563.7 1719.7 1659.4 1603.6 1675.4 1.00556860521626 0.868217385908728 0.00801151329802311 Nonsignificant None 3 Molecular Function:oligosaccharyl transferase activity (GO:0004576),Biological Process:protein glycosylation (GO:0006486),Cellular Component:membrane (GO:0016020) dolichyl-diphosphooligosaccharide---protein glycosyltransferase 2.4.99.18 ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways ko04141 Protein processing in endoplasmic reticulum Oligosaccharyltransferase, STT3 subunit O Posttranslational modification, protein turnover, chaperones ; IPR003674 [Oligosaccharyl transferase, STT3 subunit] -- -- G3UYH1 Aldehyde dehydrogenase X, mitochondrial (Fragment) Aldh1b1 159.1 152.8 272 325.8 313.9 293.5 0.625696528075439 0.043191304946757 -0.676464996191717 Significant down 3 Biological Process:metabolic process (GO:0008152),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) aldehyde dehydrogenase (NAD+) 1.2.1.3 ko00010 Glycolysis / Gluconeogenesis ko00053 Ascorbate and aldarate metabolism ko00071 Fatty acid degradation ko00280 Valine, leucine and isoleucine degradation ko00310 Lysine degradation ko00330 Arginine and proline metabolism ko00340 Histidine metabolism ko00380 Tryptophan metabolism ko00410 beta-Alanine metabolism ko00561 Glycerolipid metabolism ko00620 Pyruvate metabolism ko01100 Metabolic pathways Aldehyde dehydrogenase C Energy production and conversion ; IPR015590 [Aldehyde dehydrogenase domain] -- -- P05208 Chymotrypsin-like elastase family member 2A Cela2a 665.9 549.2 514.6 522.7 1036.7 532.6 0.826816443594646 0.529802232884459 -0.274361013747915 Nonsignificant None 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) pancreatic elastase II 3.4.21.71 ko04972 Pancreatic secretion ko04974 Protein digestion and absorption Trypsin E Amino acid transport and metabolism ; IPR001254 [Serine proteases, trypsin domain] -- -- U3M993 NAD(P)-dependent steroid dehydrogenase-like protein Nsdhl 1005.3 995.3 917.7 1019.5 1131.1 1072.3 0.90548884544975 0.0751963897026796 -0.143231225896844 Nonsignificant None 3 Molecular Function:3-beta-hydroxy-delta5-steroid dehydrogenase activity (GO:0003854),Biological Process:steroid biosynthetic process (GO:0006694),Biological Process:oxidation-reduction process (GO:0055114) sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) 1.1.1.170 ko00100 Steroid biosynthesis ko01100 Metabolic pathways C-3 sterol dehydrogenase/3-beta-hydroxysteroid dehydrogenase and related dehydrogenases IE Lipid transport and metabolism ; Amino acid transport and metabolism ; IPR002225 [3-beta hydroxysteroid dehydrogenase/isomerase] -- -- D3YYD5 Vacuolar protein sorting-associated protein 29 (Fragment) Vps29 22.9 28.4 19.2 40.3 43.2 41.2 0.565356856455493 0.00299647369215054 -0.822766302543514 Significant down -- -- vacuolar protein sorting-associated protein 29 -- ko04144 Endocytosis Membrane coat complex Retromer, subunit VPS29/PEP11 U Intracellular trafficking, secretion, and vesicular transport ; IPR024654 [Calcineurin-like phosphoesterase domain, lpxH type] -- -- Q3TCH7 Cullin-4A Cul4a 1335.4 1293.8 1779.9 2021.8 1905.5 1920.7 0.753950068399453 0.0398759347178805 -0.407459113114636 Nonsignificant None 2 Biological Process:ubiquitin-dependent protein catabolic process (GO:0006511),Molecular Function:ubiquitin protein ligase binding (GO:0031625) cullin 4 -- ko03420 Nucleotide excision repair ko04120 Ubiquitin mediated proteolysis Cullins D Cell cycle control, cell division, chromosome partitioning ; IPR001373 [Cullin, N-terminal] ; IPR019559[Cullin protein, neddylation domain] -- -- Q64674 Spermidine synthase Srm 2006.4 2165 2390.6 2124.6 2259.7 2091.1 1.01337369120054 0.825704600293845 0.0191662797919233 Nonsignificant None -- -- spermidine synthase 2.5.1.16 ko00270 Cysteine and methionine metabolism ko00330 Arginine and proline metabolism ko00410 beta-Alanine metabolism ko00480 Glutathione metabolism ko01100 Metabolic pathways Spermidine synthase E Amino acid transport and metabolism ; -- -- -- P61028 Ras-related protein Rab-8B Rab8b 510.3 589.1 566 490.5 489.1 486.4 1.13601637107776 0.104333504908723 0.183983625601855 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-8B -- ko04530 Tight junction GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- Q58E35 Ribosomal protein, large, P1 Rplp1 1309.1 1263.4 1280.1 1211 1358.5 1277.9 1.00135156209388 0.970914603634379 0.00194857541638635 Nonsignificant None -- -- large subunit ribosomal protein LP1 -- ko03010 Ribosome 60s acidic ribosomal protein P1 J Translation, ribosomal structure and biogenesis ; -- -- -- Q9R0Y5 Adenylate kinase isoenzyme 1 Ak1 1016.9 1048.6 1184.5 1329.4 1268.9 1315.9 0.830310152777068 0.0153907241291623 -0.268277755666358 Nonsignificant None -- -- adenylate kinase 2.7.4.3 ko00230 Purine metabolism ko00730 Thiamine metabolism ko01100 Metabolic pathways Uridylate kinase/adenylate kinase F Nucleotide transport and metabolism ; -- -- -- Q3TRG2 Protein kinase domain-containing protein Map3k20 239 235.2 268.4 268.3 245.1 276.5 0.940119002405368 0.325737502047169 -0.0890847069124788 Nonsignificant None 2 Molecular Function:protein kinase activity (GO:0004672),Biological Process:protein phosphorylation (GO:0006468) sterile alpha motif and leucine zipper containing kinase AZK 2.7.11.25 ko04010 MAPK signaling pathway Tyrosine kinase specific for activated (GTP-bound) p21cdc42Hs T Signal transduction mechanisms ; IPR001245 [Serine-threonine/tyrosine-protein kinase catalytic domain] -- -- P11928 2-5-oligoadenylate synthase 1A Oas1a 1161.8 1092.2 1006.1 1509 1625.1 1576 0.692150909747139 0.00100540007924176 -0.530841471754134 Nonsignificant None 1 Molecular Function:nucleotidyltransferase activity (GO:0016779) 2'-5'-oligoadenylate synthetase 2.7.7.84 ko04621 NOD-like receptor signaling pathway ko05160 Hepatitis C ko05162 Measles ko05164 Influenza A ko05168 Herpes simplex infection -- -- -- IPR002934 [Polymerase, nucleotidyl transferase domain] ; IPR018952[2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal] -- -- P97470 Serine/threonine-protein phosphatase 4 catalytic subunit Ppp4c 1099.6 1163.6 1087.2 1098.4 1175.6 1096.9 0.993918538075885 0.855342935421901 -0.00880048206357864 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) serine/threonine-protein phosphatase 4 catalytic subunit 3.1.3.16 ko04922 Glucagon signaling pathway Serine/threonine specific protein phosphatase involved in glycogen accumulation, PP2A-related GT Carbohydrate transport and metabolism ; Signal transduction mechanisms ; IPR004843 [Calcineurin-like phosphoesterase domain, ApaH type] -- -- Q9Z1A1 TFG protein Tfg 1772.2 1708.7 1777.4 1765.2 1759.6 1827.8 0.982382393603109 0.368960769504455 -0.0256433901331571 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) protein TFG -- ko05200 Pathways in cancer ko05216 Thyroid cancer -- -- -- IPR000270 [PB1 domain] -- -- Q3UE06 Uncharacterized protein Nploc4 1068.6 1065.6 1278.7 1281.6 1216.1 1166.5 0.931417499044812 0.343416872117756 -0.102500107781713 Nonsignificant None -- -- nuclear protein localization protein 4 homolog -- ko04141 Protein processing in endoplasmic reticulum Nuclear pore complex, rNpl4 component (sc Npl4) YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; IPR007716 [NPL4, zinc-binding putative] ; IPR007717[Nuclear pore localisation protein NPL4, C-terminal] ; IPR024682[Nuclear pore localisation protein Npl4, ubiquitin-like domain] -- -- Q6PA06 Atlastin-2 Atl2 2359.3 2798.3 2420 1943.1 2071.5 2145.9 1.23003003003003 0.0342423843624421 0.298693538041376 Nonsignificant None 2 Molecular Function:GTPase activity (GO:0003924),Molecular Function:GTP binding (GO:0005525) atlastin 3.6.5.- -- Guanylate-binding protein R General function prediction only ; IPR015894 [Guanylate-binding protein, N-terminal] -- -- Q0PD53 Rab6B Rab6b 96.4 104.2 83 96.9 123.3 113.1 0.850885088508851 0.168532622923572 -0.232963784870732 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-6B -- -- GTPase Rab6/YPT6/Ryh1, small G protein superfamily U Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- F6RJV6 LanC-like protein 2 (Fragment) Lancl2 625.4 560.1 553.4 506.8 528.3 547.2 1.09896985400999 0.112675996822013 0.136151812068034 Nonsignificant None -- -- -- -- -- Lanthionine synthetase C-like protein 1 V Defense mechanisms ; IPR007822 [Lanthionine synthetase C-like] -- -- B3V097 BetaCstF-64 variant 3 Cstf2 389.9 476.4 488 462.8 468.5 415 1.00594221198841 0.943397924736209 0.00854742952478066 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Biological Process:mRNA 3'-end processing (GO:0031124) cleavage stimulation factor subunit 2 -- ko03015 mRNA surveillance pathway mRNA cleavage and polyadenylation factor I complex, subunit RNA15 A RNA processing and modification ; IPR000504 [RNA recognition motif domain] ; IPR025742[Cleavage stimulation factor subunit 2, hinge domain] ; IPR026896[Transcription termination and cleavage factor, C-terminal domain] -- -- Q5U445 cDNA sequence BC085271 BC085271 4903.9 4484.1 4727.7 4212.8 4497.2 4242.6 1.08979664314501 0.0627141123829725 0.124058952160761 Nonsignificant None 2 Cellular Component:nucleus (GO:0005634),Biological Process:nucleosome assembly (GO:0006334) template-activating factor I -- -- DNA replication factor/protein phosphatase inhibitor SET/SPR-2 L Replication, recombination and repair ; IPR002164 [Nucleosome assembly protein (NAP)] -- -- Q6P5B5 Fragile X mental retardation syndrome-related protein 2 Fxr2 1503.4 1480.4 1480.6 1382.8 1297.2 1374 1.101233349778 0.00837147349830914 0.139120206319984 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) fragile X mental retardation protein -- ko03013 RNA transport -- -- -- IPR004088 [K Homology domain, type 1] ; IPR008395[Agenet-like domain] ; IPR022034[Fragile X-related 1 protein, C-terminal core] ; IPR032172[Fragile X-related 1 protein, C-terminal region 1] -- -- Q3UK08 Uncharacterized protein Tsg101 1421.4 1282.5 1277.3 1323.9 1293.7 1381.6 0.995499099819964 0.916535349014733 -0.0065080834979491 Nonsignificant None 2 Biological Process:cellular protein modification process (GO:0006464),Biological Process:protein transport (GO:0015031) ESCRT-I complex subunit TSG101 -- ko04144 Endocytosis Vacuolar sorting protein/ubiquitin receptor VPS23 OU Posttranslational modification, protein turnover, chaperones ; Intracellular trafficking, secretion, and vesicular transport ; IPR008883 [Ubiquitin E2 variant, N-terminal] ; IPR017916[Steadiness box (SB) domain] -- -- P28666 Murinoglobulin-2 Mug2 128.3 108.6 87.6 110.3 115.7 127.2 0.918742921857305 0.495230449762807 -0.122266864761965 Nonsignificant None 3 Molecular Function:endopeptidase inhibitor activity (GO:0004866),Cellular Component:extracellular region (GO:0005576),Cellular Component:extracellular space (GO:0005615) -- -- -- Alpha-macroglobulin O Posttranslational modification, protein turnover, chaperones ; IPR001599 [Alpha-2-macroglobulin] ; IPR002890[Alpha-2-macroglobulin, N-terminal] ; IPR009048[Alpha-macroglobulin, receptor-binding] ; IPR011625[Alpha-2-macroglobulin, N-terminal 2] ; IPR011626[Alpha-macroglobulin complement component] ; IPR019565[Alpha-2-macroglobulin, thiol-ester bond-forming] -- -- Q9CQC7 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 Ndufb4 2795.2 2744.4 3014.6 3226.1 3011.2 3426.2 0.885207223055829 0.0641397190894713 -0.175912871692056 Nonsignificant None 2 Cellular Component:mitochondrion (GO:0005739),Molecular Function:NADH dehydrogenase (ubiquinone) activity (GO:0008137) NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 4 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease -- -- -- IPR009866 [NADH:ubiquinone oxidoreductase, subunit NDUFB4] -- -- A2ACP1 Tetratricopeptide repeat protein 39A Ttc39a 1477.9 1387.8 1741.1 1840.7 1828.8 1831.4 0.837462960606446 0.106456499118493 -0.255902710675654 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019412 [Outer membrane protein Iml2/Tetratricopeptide repeat protein 39] -- -- Q91VW3 SH3 domain-binding glutamic acid-rich-like protein 3 Sh3bgrl3 2968 2974.9 2435.1 2747.4 2497.5 2485.9 1.08371707973302 0.337363369934915 0.115988169108212 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR006993 [SH3-binding, glutamic acid-rich protein] -- -- Q91YN9 BAG family molecular chaperone regulator 2 Bag2 1663.3 1651 1576.5 1689.9 1518.2 1328.9 1.07798104474322 0.335105666277844 0.108331809912883 Nonsignificant None -- -- BCL2-associated athanogene 2 -- ko04141 Protein processing in endoplasmic reticulum BAG family molecular chaperone regulator 2 O Posttranslational modification, protein turnover, chaperones ; -- -- -- E9Q1F5 Myosin VC Myo5c 1155 1115.5 1214.7 1527.3 1593.1 1543.8 0.747223532438575 0.000356622360796379 -0.420388204082524 Nonsignificant None 4 Molecular Function:motor activity (GO:0003774),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Cellular Component:myosin complex (GO:0016459) myosin V -- -- Myosin class V heavy chain Z Cytoskeleton ; IPR000048 [IQ motif, EF-hand binding site] ; IPR001609[Myosin head, motor domain] ; IPR002710[Dilute domain] -- -- P63328 Protein phosphatase 3 catalytic subunit alpha Ppp3ca 555.8 528.7 479.4 553.4 602.8 610.5 0.885209713024283 0.0776171113826642 -0.175908813591315 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) serine/threonine-protein phosphatase 2B catalytic subunit 3.1.3.16 ko04010 MAPK signaling pathway ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04114 Oocyte meiosis ko04218 Cellular senescence ko04310 Wnt signaling pathway ko04360 Axon guidance ko04370 VEGF signaling pathway ko04380 Osteoclast differentiation ko04650 Natural killer cell mediated cytotoxicity ko04658 Th1 and Th2 cell differentiation ko04659 Th17 cell differentiation ko04660 T cell receptor signaling pathway ko04662 B cell receptor signaling pathway ko04720 Long-term potentiation ko04724 Glutamatergic synapse ko04728 Dopaminergic synapse ko04921 Oxytocin signaling pathway ko04922 Glucagon signaling pathway ko04924 Renin secretion ko05010 Alzheimer's disease ko05014 Amyotrophic lateral sclerosis (ALS) ko05031 Amphetamine addiction ko05152 Tuberculosis ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection Serine-threonine phosphatase 2B, catalytic subunit R General function prediction only ; IPR004843 [Calcineurin-like phosphoesterase domain, ApaH type] -- -- Q3TJB4 Uncharacterized protein Sh3gl1 1450.8 1418.7 1946.4 1874.1 1954.5 1839.6 0.849634804699905 0.178171829603782 -0.235085228534047 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:cytoplasm (GO:0005737) endophilin-A -- ko04144 Endocytosis Lysophosphatidic acid acyltransferase endophilin/SH3GL, involved in synaptic vesicle formation IT Lipid transport and metabolism ; Signal transduction mechanisms ; IPR001452 [SH3 domain] ; IPR004148[BAR domain] -- -- Q80ZP8 Armet protein Manf 3798.9 4027.6 3145.1 2914.7 3077.1 2907.1 1.23291642787311 0.0628216603790592 0.302075011274195 Nonsignificant None -- -- -- -- -- Arginine-rich protein R General function prediction only ; IPR019345 [Armet protein] -- -- P45878 Peptidyl-prolyl cis-trans isomerase FKBP2 Fkbp2 2382.7 2246.4 3165.2 3075.3 2821.5 3037.7 0.872382338127483 0.269823584809913 -0.196967532787913 Nonsignificant None -- -- FK506-binding protein 2 5.2.1.8 -- FKBP-type peptidyl-prolyl cis-trans isomerase O Posttranslational modification, protein turnover, chaperones ; IPR001179 [FKBP-type peptidyl-prolyl cis-trans isomerase domain] -- -- P52503 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial Ndufs6 1580 1662.3 1671.9 2040.8 1970.1 2074.8 0.807499548121005 0.000775351879466304 -0.308466642416735 Nonsignificant None -- -- NADH dehydrogenase (ubiquinone) Fe-S protein 6 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease NADH:ubiquinone oxidoreductase, NDUFS6/13 kDa subunit C Energy production and conversion ; IPR019401 [Zinc finger, CHCC-type] -- -- P62305 Small nuclear ribonucleoprotein E Snrpe 1293.6 1310.3 1113 1246.4 1237.2 1380.8 0.961831073387848 0.564515516730543 -0.0561445595050994 Nonsignificant None -- -- small nuclear ribonucleoprotein E -- ko03040 Spliceosome Small nuclear ribonucleoprotein E A RNA processing and modification ; IPR001163 [LSM domain, eukaryotic/archaea-type] -- -- O35382 Exocyst complex component 4 Exoc4 1275.3 1259 1297.9 1385.6 1397.5 1383.3 0.919786866359447 0.00077488494053104 -0.120628497271029 Nonsignificant None 3 Cellular Component:exocyst (GO:0000145),Biological Process:vesicle docking involved in exocytosis (GO:0006904),Biological Process:protein transport (GO:0015031) exocyst complex component 4 -- -- Exocyst complex subunit Sec8 U Intracellular trafficking, secretion, and vesicular transport ; IPR007191 [Sec8 exocyst complex component specific domain] -- -- Q3UF03 MRH domain-containing protein M6pr 3281.7 3442 1732.9 1802 1782.1 1763.7 1.58132316092599 0.197536721173965 0.661132228558523 Nonsignificant None -- -- cation-dependent mannose-6-phosphate receptor -- ko04142 Lysosome ko04145 Phagosome -- -- -- IPR028927 [Mannose-6-phosphate receptor] -- -- Q8C9L6 Uncharacterized protein Pakap 1850.8 1919.8 2072.5 2147 2145.5 2110 0.912627879734479 0.0488394883182467 -0.131901367752602 Nonsignificant None -- -- A-kinase anchor protein 2 -- -- -- -- -- -- -- -- Q5SF07 Insulin-like growth factor 2 mRNA-binding protein 2 Igf2bp2 1078.9 1037 1327.3 1160.7 1104 1163.5 1.00437547400968 0.95954738941839 0.00629870477281181 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:RNA binding (GO:0003723) insulin-like growth factor 2 mRNA-binding protein 2 -- -- IGF-II mRNA-binding protein IMP, contains RRM and KH domains AR RNA processing and modification ; General function prediction only ; IPR000504 [RNA recognition motif domain] ; IPR004088[K Homology domain, type 1] -- -- Q9CRA5 Golgi phosphoprotein 3 Golph3 1848.6 1813.5 1946.6 2082.9 2106.1 2168 0.882287242409942 0.00616804939101092 -0.180679670697182 Nonsignificant None 1 Molecular Function:phosphatidylinositol-4-phosphate binding (GO:0070273) golgi phosphoprotein 3 -- -- Golgi protein U Intracellular trafficking, secretion, and vesicular transport ; IPR008628 [Golgi phosphoprotein 3-like] -- -- Q5I0T8 Ribosomal protein L19 Rpl19 3986.8 4462.9 4391.9 4105.1 4350.6 3915.9 1.03799023570112 0.465666726189903 0.0537928724319917 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L19e -- ko03010 Ribosome 60s ribosomal protein L19 J Translation, ribosomal structure and biogenesis ; IPR000196 [Ribosomal protein L19/L19e] -- -- Q9CQC9 GTP-binding protein SAR1b Sar1b 1108 1282.9 863.8 950.9 984.2 1012.6 1.10414899752349 0.48929336983881 0.142934867300886 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) GTP-binding protein SAR1 3.6.5.- ko04141 Protein processing in endoplasmic reticulum ko05134 Legionellosis Vesicle coat complex COPII, GTPase subunit SAR1 U Intracellular trafficking, secretion, and vesicular transport ; IPR006689 [Small GTPase superfamily, ARF/SAR type] -- -- Q9JHW2 Omega-amidase NIT2 Nit2 1651.2 1630.3 1915.9 1953.5 1905 2052 0.879350308772523 0.0793764151139794 -0.185490085321751 Nonsignificant None 1 Biological Process:nitrogen compound metabolic process (GO:0006807) omega-amidase 3.5.1.3 ko00250 Alanine, aspartate and glutamate metabolism Carbon-nitrogen hydrolase E Amino acid transport and metabolism ; IPR003010 [Carbon-nitrogen hydrolase] -- -- Q8R4N0 Citramalyl-CoA lyase, mitochondrial Clybl 1108.5 1073.7 1505.9 1846.6 1730.2 1926.8 0.670125009084963 0.0156478867127034 -0.577497845340656 Nonsignificant None 1 Molecular Function:catalytic activity (GO:0003824) citrate lyase subunit beta-like protein 4.1.-.- -- -- -- -- IPR005000 [HpcH/HpaI aldolase/citrate lyase domain] -- -- G3X9T7 Galectin Lgals9 1422.4 1451.4 1582.3 1719.2 1712.5 1699.3 0.868466185928669 0.0429075981207483 -0.203458416755044 Nonsignificant None 1 Molecular Function:carbohydrate binding (GO:0030246) galectin-9 -- -- Galectin, galactose-binding lectin W Extracellular structures ; IPR001079 [Galectin, carbohydrate recognition domain] -- -- D3YYK8 Microtubule-associated protein RP/EB family member 2 (Fragment) Mapre2 984.9 977.2 1084.5 1094.4 1146.5 1186.9 0.888791644786744 0.0438178781224443 -0.170082840358139 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:microtubule binding (GO:0008017) microtubule-associated protein, RP/EB family -- -- Microtubule-binding protein involved in cell cycle control DZ Cell cycle control, cell division, chromosome partitioning ; Cytoskeleton ; IPR001715 [Calponin homology domain] ; IPR004953[EB1, C-terminal] -- -- Q9CYG7 Mitochondrial import receptor subunit TOM34 Tomm34 1654.5 1710.9 1630.9 1625.8 1772.7 1550.8 1.00949629240499 0.832359051401841 0.0136356120673437 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) mitochondrial import receptor subunit TOM34 -- -- FOG: TPR repeat R General function prediction only ; IPR001440 [Tetratricopeptide repeat 1] ; IPR019734[Tetratricopeptide repeat] -- -- Q9QYE6 Golgin subfamily A member 5 Golga5 1459.4 1702.5 1297.1 1308.7 1392.9 1162.1 1.15407510935114 0.217579282057797 0.20673712031113 Nonsignificant None 1 Biological Process:Golgi organization (GO:0007030) -- -- -- Golgi integral membrane protein UR Intracellular trafficking, secretion, and vesicular transport ; General function prediction only ; IPR019177 [Golgin subfamily A member 5] -- -- O09044 Synaptosomal-associated protein 23 Snap23 1770.7 1778.8 1807.6 1824.6 1854.6 1864.9 0.966270449667214 0.019384642479017 -0.049501053046477 Nonsignificant None -- -- synaptosomal-associated protein 23 -- ko04130 SNARE interactions in vesicular transport ko04611 Platelet activation SNAP-25 (synaptosome-associated protein) component of SNARE complex U Intracellular trafficking, secretion, and vesicular transport ; IPR000928 [SNAP-25] -- -- Q9JKV1 Proteasomal ubiquitin receptor ADRM1 Adrm1 1410.2 1321 1202.3 1146.1 1178.9 1167 1.12643184421535 0.131155327398395 0.171760024636655 Nonsignificant None 2 Cellular Component:nucleus (GO:0005634),Cellular Component:cytoplasm (GO:0005737) 26S proteasome regulatory subunit N13 -- ko03050 Proteasome ko05169 Epstein-Barr virus infection Cell membrane glycoprotein R General function prediction only ; IPR006773 [26S proteasome complex ubiquitin receptor, subunit Rpn13] ; IPR032368[UCH-binding domain] -- -- Q9D6P8 Calmodulin-like protein 3 Calml3 11.4 14.8 25.6 25.4 31.5 18.1 0.690666666666667 0.251431245802107 -0.533938497696689 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) calmodulin -- ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04070 Phosphatidylinositol signaling system ko04114 Oocyte meiosis ko04218 Cellular senescence ko04261 Adrenergic signaling in cardiomyocytes ko04270 Vascular smooth muscle contraction ko04371 Apelin signaling pathway ko04713 Circadian entrainment ko04720 Long-term potentiation ko04722 Neurotrophin signaling pathway ko04728 Dopaminergic synapse ko04740 Olfactory transduction ko04744 Phototransduction ko04750 Inflammatory mediator regulation of TRP channels ko04910 Insulin signaling pathway ko04912 GnRH signaling pathway ko04915 Estrogen signaling pathway ko04916 Melanogenesis ko04921 Oxytocin signaling pathway ko04922 Glucagon signaling pathway ko04924 Renin secretion ko04925 Aldosterone synthesis and secretion ko04970 Salivary secretion ko04971 Gastric acid secretion ko05010 Alzheimer's disease ko05031 Amphetamine addiction ko05034 Alcoholism ko05133 Pertussis ko05152 Tuberculosis ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05200 Pathways in cancer ko05214 Glioma ko05418 Fluid shear stress and atherosclerosis Calmodulin and related proteins (EF-Hand superfamily) T Signal transduction mechanisms ; IPR002048 [EF-hand domain] -- -- R4H4V1 N-terminal kinase-like protein Scyl1 1477.5 1483.2 1468.6 1396.2 1426.6 1366.9 1.05718786547963 0.0108280046340533 0.0802317707723767 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) SCY1-like protein 1 -- -- Protein kinase R General function prediction only ; IPR000719 [Protein kinase domain] -- -- Q8VDP3 [F-actin]-monooxygenase MICAL1 Mical1 1440.5 1449.2 1251.2 1355.5 1380.9 1455.5 0.987833679238531 0.823093012510695 -0.0176599380336236 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:FAD binding (GO:0071949) F-actin monooxygenase 1.14.13.225 -- Regulatory protein MLP and related LIM proteins TZ Signal transduction mechanisms ; Cytoskeleton ; IPR001715 [Calponin homology domain] ; IPR002938[FAD-binding domain] ; IPR022735[Domain of unknown function DUF3585] -- -- E0CYH7 Filamin A-interacting protein 1-like Filip1l 2483.2 2608.5 2597.2 2840 2853.5 2747.7 0.910877600341184 0.00852233202356927 -0.134670890744368 Nonsignificant None -- -- -- -- -- -- -- -- IPR019131 [Cortactin-binding protein-2, N-terminal] -- -- Q8K224 RNA cytidine acetyltransferase Nat10 1068.4 1191.6 1123.7 978.6 1031 991.9 1.12733633183408 0.0307474970756022 0.172917996326925 Nonsignificant None 1 Molecular Function:N-acetyltransferase activity (GO:0008080) N-acetyltransferase 10 2.3.1.- ko03008 Ribosome biogenesis in eukaryotes Predicted P-loop ATPase fused to an acetyltransferase R General function prediction only ; IPR000182 [GNAT domain] ; IPR007807[Helicase domain] ; IPR013562[tRNA(Met) cytidine acetyltransferase TmcA, N-terminal] ; IPR027992[Possible tRNA binding domain] -- -- P40336 Vacuolar protein sorting-associated protein 26A Vps26a 1365.2 1328.6 1401.8 1370.6 1363.3 1413.6 0.98748643761302 0.546895681070162 -0.0181671609105663 Nonsignificant None -- -- vacuolar protein sorting-associated protein 26 -- ko04144 Endocytosis Membrane coat complex Retromer, subunit VPS26 U Intracellular trafficking, secretion, and vesicular transport ; IPR028934 [Vacuolar protein sorting protein 26 related] -- -- Q9D1M0 Protein SEC13 homolog Sec13 2005.7 2068.7 2911.8 3271.3 3190.6 2756.1 0.757886743328271 0.0892401578507708 -0.399945823069753 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) protein transport protein SEC13 -- ko03013 RNA transport ko04141 Protein processing in endoplasmic reticulum ko04150 mTOR signaling pathway Vesicle coat complex COPII, subunit SEC13 U Intracellular trafficking, secretion, and vesicular transport ; IPR001680 [WD40 repeat] -- -- P28659 CUGBP Elav-like family member 1 Celf1 1892.9 1845.9 2195.3 2087.6 2092.3 2178.5 0.933269375943634 0.28034025488373 -0.099634538733661 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) CUG-BP- and ETR3-like factor -- -- RNA-binding protein CUGBP1/BRUNO (RRM superfamily) A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- A2AL50 Alkylglycerone-phosphate synthase Agps 1450.3 1490.5 1371 1221 1253.1 1294.5 1.14413840683543 0.0115923863679365 0.194261586012282 Nonsignificant None 4 Molecular Function:catalytic activity (GO:0003824),Molecular Function:oxidoreductase activity (GO:0016491),Molecular Function:flavin adenine dinucleotide binding (GO:0050660),Biological Process:oxidation-reduction process (GO:0055114) alkyldihydroxyacetonephosphate synthase 2.5.1.26 ko00565 Ether lipid metabolism ko01100 Metabolic pathways ko04146 Peroxisome Alkyl-dihydroxyacetonephosphate synthase R General function prediction only ; IPR004113 [FAD-linked oxidase, C-terminal] ; IPR006094[FAD linked oxidase, N-terminal] -- -- Q64282 Interferon-induced protein with tetratricopeptide repeats 1 Ifit1 1586.3 1546 1771.9 1960 2213.4 2366.4 0.749900608581302 0.0165720387215459 -0.415228700624122 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) interferon-induced protein with tetratricopeptide repeats 1 -- ko05160 Hepatitis C ko05168 Herpes simplex infection FOG: TPR repeat R General function prediction only ; IPR019734 [Tetratricopeptide repeat] -- -- Q91V89 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Ppp2r5d 574.6 496.3 506.4 509.2 474.4 487.9 1.07189942235814 0.255468908718881 0.100169542295204 Nonsignificant None 3 Cellular Component:protein phosphatase type 2A complex (GO:0000159),Biological Process:signal transduction (GO:0007165),Molecular Function:protein phosphatase regulator activity (GO:0019888) serine/threonine-protein phosphatase 2A regulatory subunit B' -- ko03015 mRNA surveillance pathway ko04071 Sphingolipid signaling pathway ko04114 Oocyte meiosis ko04151 PI3K-Akt signaling pathway ko04152 AMPK signaling pathway ko04261 Adrenergic signaling in cardiomyocytes ko04728 Dopaminergic synapse ko05165 Human papillomavirus infection Serine/threonine protein phosphatase 2A, regulatory subunit T Signal transduction mechanisms ; IPR002554 [Protein phosphatase 2A, regulatory B subunit, B56] -- -- P06802 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Enpp1 976.8 911.8 1024 1102.7 965.3 1173.3 0.898590071884738 0.188460822945678 -0.154264972622917 Nonsignificant None 7 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:catalytic activity (GO:0003824),Molecular Function:scavenger receptor activity (GO:0005044),Biological Process:immune response (GO:0006955),Molecular Function:hydrolase activity (GO:0016787),Molecular Function:polysaccharide binding (GO:0030247),Molecular Function:metal ion binding (GO:0046872) -- -- ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko00500 Starch and sucrose metabolism ko00740 Riboflavin metabolism ko00760 Nicotinate and nicotinamide metabolism ko00770 Pantothenate and CoA biosynthesis ko01100 Metabolic pathways Type I phosphodiesterase/nucleotide pyrophosphatase R General function prediction only ; IPR001212 [Somatomedin B domain] ; IPR001604[DNA/RNA non-specific endonuclease] ; IPR002591[Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase] -- -- P13745 Glutathione S-transferase A1 Gsta1 2418.2 2251.7 1992.5 2229.2 2161.5 2803.4 0.92609221445351 0.498403654300387 -0.110772239726855 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) glutathione S-transferase 2.5.1.18 ko00480 Glutathione metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko01524 Platinum drug resistance ko05200 Pathways in cancer ko05204 Chemical carcinogenesis ko05225 Hepatocellular carcinoma ko05418 Fluid shear stress and atherosclerosis Glutathione S-transferase O Posttranslational modification, protein turnover, chaperones ; IPR004045 [Glutathione S-transferase, N-terminal] ; IPR004046[Glutathione S-transferase, C-terminal] -- -- Q3TDG9 t-SNARE coiled-coil homology domain-containing protein Stx12 1187.6 1180 1201.8 1247.8 1219.6 1222.5 0.967343288436001 0.0217484872405638 -0.0479001342075932 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) syntaxin 12/13 -- ko04145 Phagosome SNARE protein PEP12/VAM3/Syntaxin 7/Syntaxin 17 U Intracellular trafficking, secretion, and vesicular transport ; IPR000727 [Target SNARE coiled-coil homology domain] -- -- Q791V5 Mitochondrial carrier homolog 2 Mtch2 2286.9 2130.8 2215.9 2009 1995.3 2054 1.09496063252067 0.0167414444959566 0.130879001070127 Nonsignificant None -- -- mitochondrial carrier -- -- Mitochondrial carrier protein R General function prediction only ; IPR018108 [Mitochondrial substrate/solute carrier] -- -- Q3U4G8 Coronin Coro2a 2190.1 1964.8 2337.1 2113 2138.3 2178.8 1.00962659989736 0.860272411520107 0.0138218255702583 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) coronin-2 -- -- Actin-binding protein Coronin, contains WD40 repeats Z Cytoskeleton ; IPR001680 [WD40 repeat] ; IPR015048[Domain of unknown function DUF1899] -- -- Q9CY27 Very-long-chain enoyl-CoA reductase Tecr 2962.9 3029.7 3307.5 3201.3 3202.9 3349.1 0.95353367578153 0.263900566391947 -0.0686442040419501 Nonsignificant None 3 Cellular Component:cytoplasm (GO:0005737),Biological Process:lipid metabolic process (GO:0006629),Cellular Component:integral component of membrane (GO:0016021) very-long-chain enoyl-CoA reductase 1.3.1.93 ko00062 Fatty acid elongation ko01040 Biosynthesis of unsaturated fatty acids ko01212 Fatty acid metabolism Steroid reductase required for elongation of the very long chain fatty acids I Lipid transport and metabolism ; IPR001104 [3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal] -- -- Q9D7N3 28S ribosomal protein S9, mitochondrial Mrps9 1276.4 1242.2 1379.3 1325.4 1320.2 1339.8 0.978044863752697 0.553482323451355 -0.0320274505390758 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S9 -- ko03010 Ribosome Mitochondrial/chloroplast ribosomal protein S9 J Translation, ribosomal structure and biogenesis ; IPR000754 [Ribosomal protein S9] -- -- Q3U0T9 Rab35 Rab35 1634.9 1652.1 999 979.4 971 1046.1 1.43033539128984 0.182079769142615 0.516353476106117 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-35 -- ko04144 Endocytosis GTP-binding protein H-ray, small G protein superfamily R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- Q505L1 Actl6a protein Actl6a 1211.5 1167.8 928.7 968.4 987.2 953 1.13731692223063 0.26825344888014 0.185634328478444 Nonsignificant None -- -- actin-like protein 6A -- ko05225 Hepatocellular carcinoma Actin-related protein - Arp4p/Act3p Z Cytoskeleton ; IPR004000 [Actin family] -- -- P56677 Suppressor of tumorigenicity 14 protein homolog St14 2006.5 1939.4 2099.4 2031.4 2186.3 2143.5 0.950339558573854 0.182971352211737 -0.0734850109778632 Nonsignificant None 3 Molecular Function:serine-type endopeptidase activity (GO:0004252),Molecular Function:protein binding (GO:0005515),Biological Process:proteolysis (GO:0006508) suppressor of tumorigenicity protein 14 3.4.21.109 ko05206 MicroRNAs in cancer Trypsin E Amino acid transport and metabolism ; IPR000082 [SEA domain] ; IPR000859[CUB domain] ; IPR001254[Serine proteases, trypsin domain] ; IPR002172[Low-density lipoprotein (LDL) receptor class A repeat] -- -- Q60766 Immunity-related GTPase family M protein 1 Irgm1 2079.9 2240.2 2192.5 2103 2156 2056.8 1.03115994806675 0.302640042877638 0.044268133273367 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Cellular Component:membrane (GO:0016020) immunity-related GTPase family M protein 3.6.5.- ko05145 Toxoplasmosis -- -- -- IPR007743 [Immunity-related GTPases-like] -- -- P70158 Acid sphingomyelinase-like phosphodiesterase 3a Smpdl3a 1357.4 1279.1 1419.7 1600.5 1799.2 1592.1 0.812572619095316 0.0168222688032339 -0.299431343364067 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) sphingomyelin phosphodiesterase acid-like 3 3.1.4.- -- Acid sphingomyelinase and PHM5 phosphate metabolism protein I Lipid transport and metabolism ; IPR004843 [Calcineurin-like phosphoesterase domain, ApaH type] -- -- D2CGM5 RNA helicase Ifih1 1982.3 1908.1 2037.8 2209.9 2289.9 2261.1 0.876835924211274 0.00329933088698793 -0.189621187761664 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Molecular Function:ATP binding (GO:0005524),Molecular Function:hydrolase activity (GO:0016787) interferon-induced helicase C domain-containing protein 1 3.6.4.13 ko04622 RIG-I-like receptor signaling pathway ko05161 Hepatitis B ko05162 Measles ko05164 Influenza A ko05168 Herpes simplex infection DEAD-box like helicase R General function prediction only ; IPR001650 [Helicase, C-terminal] ; IPR006935[Helicase/UvrB, N-terminal] ; IPR021673[C-terminal domain of RIG-I] ; IPR031964[Caspase recruitment domain] -- -- Q8K2I3 Dimethylaniline monooxygenase [N-oxide-forming] 2 Fmo2 2870.8 2426.7 2027.7 2176.3 2357.8 2890.9 0.986558922558923 0.923272906195818 -0.0195228759253915 Nonsignificant None 4 Molecular Function:N,N-dimethylaniline monooxygenase activity (GO:0004499),Molecular Function:flavin adenine dinucleotide binding (GO:0050660),Molecular Function:NADP binding (GO:0050661),Biological Process:oxidation-reduction process (GO:0055114) dimethylaniline monooxygenase (N-oxide forming) 1.14.13.8 ko00982 Drug metabolism - cytochrome P450 Flavin-containing monooxygenase Q Secondary metabolites biosynthesis, transport and catabolism ; IPR020946 [Flavin monooxygenase-like] -- -- Q99P72 Reticulon-4 Rtn4 149.4 137 122 141.9 155.5 155.4 0.901943462897526 0.179905668740265 -0.148891091954081 Nonsignificant None -- -- reticulon-4 -- ko05010 Alzheimer's disease Reticulon U Intracellular trafficking, secretion, and vesicular transport ; IPR003388 [Reticulon] -- -- Q561N5 40S ribosomal protein S18 Rps18 8414.1 9280 9940.3 8807.2 9025.5 8224.8 1.06051616617097 0.354490181524911 0.0847666130202095 Nonsignificant None 5 Molecular Function:RNA binding (GO:0003723),Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S18e -- ko03010 Ribosome Ribosomal protein S18 J Translation, ribosomal structure and biogenesis ; IPR001892 [Ribosomal protein S13] -- -- Q3UB06 Protein kinase domain-containing protein Srpk1 785.1 864.1 801.5 708.3 752.2 723.8 1.12196126905645 0.0312496583851378 0.166022873892662 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) serine/threonine-protein kinase SRPK1 2.7.11.1 ko05168 Herpes simplex infection Serine/threonine protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q8CGB3 Uveal autoantigen with coiled-coil domains and ankyrin repeats Uaca 1395.6 1395.4 1499.1 1458.5 1423.6 1472.9 0.985097588978186 0.594990839226837 -0.02166144223623 Nonsignificant None -- -- -- -- -- -- -- -- IPR020683 [Ankyrin repeat-containing domain] -- -- G3UVU2 Splicing factor 3A subunit 2 Sf3a2 1762.3 1709 1702.1 1582.2 1654.7 1616.4 1.06595512331815 0.0195753678669088 0.0921467019533951 Nonsignificant None -- -- splicing factor 3A subunit 2 -- ko03040 Spliceosome Splicing factor 3a, subunit 2 A RNA processing and modification ; IPR031781 [SF3A2 domain] -- -- Q9WTX2 Interferon-inducible double-stranded RNA-dependent protein kinase activator A Prkra 1415.8 1398.9 1526 1481.3 1465.2 1544.7 0.966490024937656 0.342803807731107 -0.0491732523083164 Nonsignificant None -- -- -- -- -- Staufen and related double-stranded-RNA-binding proteins UK Intracellular trafficking, secretion, and vesicular transport ; Transcription ; IPR014720 [Double-stranded RNA-binding domain] ; IPR032478[Staufen, C-terminal] -- -- D3Z7F1 Cytochrome P450 Cyp2s1 1614.1 1563.5 2175.5 2919.4 2594.1 3041 0.625764217663218 0.010829135491012 -0.676308929877954 Significant down 3 Molecular Function:iron ion binding (GO:0005506),Molecular Function:heme binding (GO:0020037),Biological Process:oxidation-reduction process (GO:0055114) cytochrome P450 family 2 subfamily S polypeptide 1 1.14.14.1 ko00830 Retinol metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko01100 Metabolic pathways Cytochrome P450 CYP2 subfamily Q Secondary metabolites biosynthesis, transport and catabolism ; IPR001128 [Cytochrome P450] -- -- E9Q5L3 Short/branched chain-specific acyl-CoA dehydrogenase, mitochondrial Acadsb 2265.9 2317.2 2312.1 2505 2409.5 2536.4 0.925418405830168 0.0111315373079536 -0.111822301651069 Nonsignificant None 4 Molecular Function:acyl-CoA dehydrogenase activity (GO:0003995),Biological Process:metabolic process (GO:0008152),Molecular Function:flavin adenine dinucleotide binding (GO:0050660),Biological Process:oxidation-reduction process (GO:0055114) short/branched chain acyl-CoA dehydrogenase 1.3.99.12 ko00071 Fatty acid degradation ko00280 Valine, leucine and isoleucine degradation ko01100 Metabolic pathways ko01212 Fatty acid metabolism Short-chain acyl-CoA dehydrogenase I Lipid transport and metabolism ; IPR006091 [Acyl-CoA oxidase/dehydrogenase, central domain] ; IPR009075[Acyl-CoA dehydrogenase/oxidase C-terminal] ; IPR013786[Acyl-CoA dehydrogenase/oxidase, N-terminal] -- -- D3Z0M9 RNA helicase Ddx23 1945.5 1945.7 2045.8 2084.7 1983.7 2001.3 0.978137304973887 0.387636793389892 -0.0318910987272508 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase DDX23/PRP28 3.6.4.13 ko03040 Spliceosome U5 snRNP-like RNA helicase subunit A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR011545[DEAD/DEAH box helicase domain] -- -- Q9D679 Ig-like domain-containing protein Tapbp 916.4 1000.3 945.4 953.1 1076.2 983.2 0.95007468879668 0.322678804311743 -0.073887161526895 Nonsignificant None -- -- TAP binding protein (tapasin) -- ko04612 Antigen processing and presentation -- -- -- IPR003597 [Immunoglobulin C1-set] -- -- A0A0R4J0T8 ADP-ribosylation factor GTPase-activating protein 3 Arfgap3 2103.6 1970.4 1958.4 2322.9 2346.8 2277.1 0.868371048540335 0.00388938635620946 -0.203616467533512 Nonsignificant None 1 Molecular Function:GTPase activator activity (GO:0005096) ADP-ribosylation factor GTPase-activating protein 2/3 -- ko04144 Endocytosis Predicted GTPase-activating protein T Signal transduction mechanisms ; IPR001164 [Arf GTPase activating protein] -- -- B9EHZ5 Membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) Pals2 1988.8 1935.1 2178.5 2173.5 2198.1 2186.4 0.930527599878011 0.174861829153961 -0.103879152967667 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Calcium/calmodulin-dependent serine protein kinase/membrane-associated guanylate kinase T Signal transduction mechanisms ; IPR001478 [PDZ domain] ; IPR008145[Guanylate kinase/L-type calcium channel beta subunit] ; IPR011511[Variant SH3 domain] ; IPR014775[L27 domain, C-terminal] -- -- P31324 cAMP-dependent protein kinase type II-beta regulatory subunit Prkar2b 100.7 87.8 97.5 98.7 99 127.1 0.880541871921182 0.272963001894854 -0.183536485519424 Nonsignificant None -- -- cAMP-dependent protein kinase regulator -- ko04910 Insulin signaling pathway cAMP-dependent protein kinase types I and II, regulatory subunit T Signal transduction mechanisms ; IPR000595 [Cyclic nucleotide-binding domain] ; IPR003117[cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain] -- -- A2ALF2 DnaJ (Hsp40) homolog, subfamily C, member 8 Dnajc8 2239.9 2182 2004.3 1769.3 1790 1916.1 1.17364941374146 0.0198827851474637 0.231001518675927 Nonsignificant None -- -- DnaJ homolog subfamily C member 8 -- -- Predicted molecular chaperone (DnaJ superfamily) O Posttranslational modification, protein turnover, chaperones ; IPR001623 [DnaJ domain] -- -- Q9DCT8 Cysteine-rich protein 2 Crip2 1818.4 1811.7 1496.6 1906.2 2036 2033 0.857996385058241 0.0688725210875178 -0.220956525565264 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) -- -- -- Regulatory protein MLP and related LIM proteins TZ Signal transduction mechanisms ; Cytoskeleton ; IPR001781 [Zinc finger, LIM-type] -- -- A0A8I4SYN6 Histone H3 H3f4 135.9 195.6 189.6 217.4 187.9 159.2 0.92311780336581 0.598714254005135 -0.115413326228814 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) histone H3 -- ko05034 Alcoholism ko05202 Transcriptional misregulation in cancer ko05322 Systemic lupus erythematosus Histones H3 and H4 B Chromatin structure and dynamics ; IPR007125 [Histone H2A/H2B/H3] -- -- Q9Z2X8 Kelch-like ECH-associated protein 1 Keap1 1911.2 1788 1508.1 1239.9 1349.3 1389.5 1.30879432980622 0.0324181604188984 0.388238403103355 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) kelch-like protein 19 -- ko04120 Ubiquitin mediated proteolysis ko05200 Pathways in cancer ko05225 Hepatocellular carcinoma ko05418 Fluid shear stress and atherosclerosis Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes TR Signal transduction mechanisms ; General function prediction only ; IPR000210 [BTB/POZ domain] ; IPR006652[Kelch repeat type 1] ; IPR011705[BTB/Kelch-associated] -- ZBTB Q5SRX1 TOM1-like protein 2 Tom1l2 1033.8 1008.5 1150.7 1314.8 1288.9 1263.6 0.825640627828201 0.00826365889569446 -0.276414130758795 Nonsignificant None 2 Cellular Component:intracellular (GO:0005622),Biological Process:intracellular protein transport (GO:0006886) -- -- -- Cytosolic sorting protein GGA2/TOM1 U Intracellular trafficking, secretion, and vesicular transport ; IPR002014 [VHS domain] ; IPR004152[GAT domain] -- -- Q3TUR1 Dolichyl-diphosphooligosaccharide--protein glycotransferase Stt3a 2043.9 2122.4 2108.5 2207.9 2224.4 2134 0.9556066582398 0.0577452099517352 -0.0655111890042975 Nonsignificant None 3 Molecular Function:oligosaccharyl transferase activity (GO:0004576),Biological Process:protein glycosylation (GO:0006486),Cellular Component:membrane (GO:0016020) dolichyl-diphosphooligosaccharide---protein glycosyltransferase 2.4.99.18 ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways ko04141 Protein processing in endoplasmic reticulum Oligosaccharyltransferase, STT3 subunit O Posttranslational modification, protein turnover, chaperones ; IPR003674 [Oligosaccharyl transferase, STT3 subunit] -- -- O88967 ATP-dependent zinc metalloprotease YME1L1 Yme1l1 1805.8 1842.1 1997.7 1834.6 1919.9 1769.4 1.02203153569036 0.609121369323163 0.0314397125986027 Nonsignificant None 3 Molecular Function:metalloendopeptidase activity (GO:0004222),Molecular Function:ATP binding (GO:0005524),Biological Process:proteolysis (GO:0006508) ATP-dependent metalloprotease 3.4.24.- AAA+-type ATPase containing the peptidase M41 domain O Posttranslational modification, protein turnover, chaperones ; IPR000642 [Peptidase M41] ; IPR003959[ATPase, AAA-type, core] -- -- P67871 Casein kinase II subunit beta Csnk2b 2114.5 2000.5 2262.3 2266.1 2231 2264.9 0.943108547766933 0.230828243853943 -0.0845042663914061 Nonsignificant None 2 Cellular Component:protein kinase CK2 complex (GO:0005956),Molecular Function:protein kinase regulator activity (GO:0019887) casein kinase II subunit beta -- ko03008 Ribosome biogenesis in eukaryotes ko04064 NF-kappa B signaling pathway ko04137 Mitophagy - animal ko04310 Wnt signaling pathway ko04520 Adherens junction ko05162 Measles ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection Casein kinase II, beta subunit TDK Signal transduction mechanisms ; Cell cycle control, cell division, chromosome partitioning ; Transcription ; IPR000704 [Casein kinase II, regulatory subunit] -- -- A2AQ25 Sickle tail protein Skt 2363.4 2400.5 2747.5 2715.7 2719.6 2629.8 0.931346170537253 0.216179626317639 -0.102610594458966 Nonsignificant None -- -- -- -- -- -- -- -- IPR022782 [Actin interacting protein 3, C-terminal] -- -- Q9D809 RIKEN cDNA 2200002D01 gene 2200002D01Rik 1143.5 1035.8 1155.1 1269.4 1298.1 1200.9 0.884831758836641 0.0386372636029124 -0.176524926432905 Nonsignificant None 1 Cellular Component:nucleus (GO:0005634) -- -- -- -- -- -- IPR026621 [Immortalization up-regulated protein] -- -- Q80X82 Symplekin Sympk 1108.5 1102.1 1110.6 978.8 934.2 982.3 1.14710047318067 0.000827203574331701 0.197991760849133 Nonsignificant None -- -- symplekin -- ko03015 mRNA surveillance pathway ko04530 Tight junction mRNA cleavage and polyadenylation factor II complex, subunit PTA1 A RNA processing and modification ; IPR022075 [Symplekin C-terminal] ; IPR032460[Symplekin/Pta1, N-terminal] -- -- Q9CX56 26S proteasome non-ATPase regulatory subunit 8 Psmd8 2622.5 2624.7 3009.4 2819.3 2829.2 2726.5 0.985862686567164 0.780951260188371 -0.0205413764829487 Nonsignificant None -- -- 26S proteasome regulatory subunit N12 -- ko03050 Proteasome ko05169 Epstein-Barr virus infection 26S proteasome regulatory complex, subunit RPN12/PSMD8 O Posttranslational modification, protein turnover, chaperones ; IPR033464 [CSN8/PSMD8/EIF3K] -- -- Q544I1 Protein NDRG3 Ndrg3 1316.2 1329.4 1791.7 1950.6 2004.5 1929.6 0.754040137984944 0.0880679731027418 -0.40728677387274 Nonsignificant None -- -- -- -- -- Differentiation-related gene 1 protein (NDR1 protein), related proteins S Function unknown ; IPR004142 [NDRG] -- -- Q9QUH0 Glutaredoxin-1 Glrx 1796.3 1850.9 1986.2 2004.3 1952.1 2230.7 0.910507345929434 0.145995399349739 -0.135257438044158 Nonsignificant None 3 Molecular Function:electron carrier activity (GO:0009055),Molecular Function:protein disulfide oxidoreductase activity (GO:0015035),Biological Process:cell redox homeostasis (GO:0045454) glutaredoxin 3 -- -- Glutaredoxin and related proteins O Posttranslational modification, protein turnover, chaperones ; IPR002109 [Glutaredoxin] -- -- G3UYV7 40S ribosomal protein S28 (Fragment) Rps28 3927.8 3932.2 3746.8 3058.8 3314.8 3264.7 1.20423726175778 0.00272151807871905 0.268119663392544 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S28e -- ko03010 Ribosome 40S ribosomal protein S28 J Translation, ribosomal structure and biogenesis ; IPR000289 [Ribosomal protein S28e] -- -- P83917 Chromobox protein homolog 1 Cbx1 1137.1 1118.3 900.9 809 826.2 883.2 1.2532957433291 0.0546503875353526 0.325726891187638 Nonsignificant None 1 Cellular Component:nucleus (GO:0005634) chromobox protein 1 -- -- Heterochromatin-associated protein HP1 and related CHROMO domain proteins B Chromatin structure and dynamics ; IPR008251 [Chromo shadow domain] ; IPR023780[Chromo domain] -- -- A0A2R8VHX0 Cysteine sulfinic acid decarboxylase Csad 1272.7 1231.7 960.3 1343.9 1302 1484.9 0.838747942287208 0.119795214476395 -0.253690772955384 Nonsignificant None 3 Molecular Function:carboxy-lyase activity (GO:0016831),Biological Process:carboxylic acid metabolic process (GO:0019752),Molecular Function:pyridoxal phosphate binding (GO:0030170) sulfinoalanine decarboxylase 4.1.1.29 ko00430 Taurine and hypotaurine metabolism ko01100 Metabolic pathways Glutamate decarboxylase and related proteins E Amino acid transport and metabolism ; IPR002129 [Pyridoxal phosphate-dependent decarboxylase] -- -- P62071 Ras-related protein R-Ras2 Rras2 710.3 633.2 654.5 773.6 756.8 859.8 0.835913312693498 0.02925265530103 -0.258574757643094 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein R-Ras2 -- ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04024 cAMP signaling pathway ko04072 Phospholipase D signaling pathway ko04137 Mitophagy - animal ko04140 Autophagy - animal ko04218 Cellular senescence ko04371 Apelin signaling pathway ko04810 Regulation of actin cytoskeleton ko05166 HTLV-I infection ko05205 Proteoglycans in cancer Ras-related GTPase R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- O88986 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial Gcat 549.8 508 567.4 615.9 763.8 670.6 0.792664488123689 0.0384463165687049 -0.335217750705883 Nonsignificant None 2 Biological Process:biosynthetic process (GO:0009058),Molecular Function:pyridoxal phosphate binding (GO:0030170) glycine C-acetyltransferase 2.3.1.29 ko00260 Glycine, serine and threonine metabolism Glycine C-acetyltransferase/2-amino-3-ketobutyrate-CoA ligase E Amino acid transport and metabolism ; IPR004839 [Aminotransferase, class I/classII] -- -- Q60676 Serine/threonine-protein phosphatase 5 Ppp5c 1207.3 1124.9 1305.9 1413.1 1342.1 1342.8 0.887774524158126 0.0556989778355181 -0.171734785636475 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:hydrolase activity (GO:0016787) serine/threonine-protein phosphatase 5 3.1.3.16 ko04010 MAPK signaling pathway Serine-threonine phosphatase 2A, catalytic subunit R General function prediction only ; IPR001440 [Tetratricopeptide repeat 1] ; IPR004843[Calcineurin-like phosphoesterase domain, ApaH type] ; IPR013235[PPP domain] -- -- Q3UGH8 IBB domain-containing protein (Fragment) Kpna4 697.9 719.5 817.7 807.4 831.1 798.6 0.9171146034221 0.152090189314512 -0.124826069400809 Nonsignificant None 5 Molecular Function:protein binding (GO:0005515),Cellular Component:nucleus (GO:0005634),Cellular Component:cytoplasm (GO:0005737),Biological Process:protein import into nucleus (GO:0006606),Molecular Function:protein transporter activity (GO:0008565) -- -- -- Karyopherin (importin) alpha U Intracellular trafficking, secretion, and vesicular transport ; IPR000225 [Armadillo] ; IPR002652[Importin-alpha, importin-beta-binding domain] ; IPR032413[Atypical Arm repeat] -- -- Q9CWZ7 Gamma-soluble NSF attachment protein Napg 2177.7 2159.2 2411 2297.2 2284.8 2445.5 0.960213447171825 0.38693898843572 -0.0585729547331153 Nonsignificant None -- -- gamma-soluble NSF attachment protein -- -- Protein required for fusion of vesicles in vesicular transport, gamma-SNAP U Intracellular trafficking, secretion, and vesicular transport ; -- -- -- Q3TUQ5 Pinin Pnn 2434.1 2499.7 2397.5 2189.7 2228.8 2213.5 1.10544330518697 0.0018846702239254 0.144625035626298 Nonsignificant None -- -- pinin -- ko03013 RNA transport ko03015 mRNA surveillance pathway Pinin (desmosome-associated protein) Z Cytoskeleton ; IPR006786 [Pinin/SDK/MemA protein] ; IPR006787[Pinin/SDK] -- -- Q99M31 Heat shock 70 kDa protein 14 Hspa14 1400.1 1388.4 1374.3 1394 1416.1 1421.2 0.983811121877437 0.11097658394499 -0.0235467302238368 Nonsignificant None -- -- -- -- -- Molecular chaperones HSP70/HSC70, HSP70 superfamily O Posttranslational modification, protein turnover, chaperones ; IPR013126 [Heat shock protein 70 family] -- -- Q5SWZ0 Prpsap2 protein Prpsap2 449.3 457 459.4 465.1 482.3 481.6 0.955703289013296 0.0299180546694848 -0.0653653113165485 Nonsignificant None 3 Molecular Function:magnesium ion binding (GO:0000287),Molecular Function:ribose phosphate diphosphokinase activity (GO:0004749),Biological Process:nucleotide biosynthetic process (GO:0009165) -- -- -- Phosphoribosylpyrophosphate synthetase-associated protein EF Amino acid transport and metabolism ; Nucleotide transport and metabolism ; IPR005946 [Ribose-phosphate diphosphokinase] ; IPR029099[Ribose-phosphate pyrophosphokinase, N-terminal domain] -- -- Q3UL32 J domain-containing protein Dnajc7 1985.6 1969.5 1747.7 1706.6 1748 1783.5 1.08871537389511 0.124599104214354 0.122626835284125 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) DnaJ homolog subfamily C member 7 -- -- Molecular chaperone (DnaJ superfamily) O Posttranslational modification, protein turnover, chaperones ; IPR001623 [DnaJ domain] ; IPR011990[Tetratricopeptide-like helical domain] ; IPR019734[Tetratricopeptide repeat] -- -- P62748 Hippocalcin-like protein 1 Hpcal1 1114.4 1099.5 1340.2 1501.4 1565.5 1487.8 0.780314839616221 0.0149274411608784 -0.357871758210746 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) -- -- -- Ca2+ sensor (EF-Hand superfamily) T Signal transduction mechanisms ; IPR002048 [EF-hand domain] -- -- Q8VBZ3 Putative lipid scramblase CLPTM1 Clptm1 1125 1098.1 1147.4 948.2 1034.5 1009.5 1.12642871465811 0.0126545485163772 0.171756016402155 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) -- -- -- Transmembrane protein R General function prediction only ; IPR008429 [Cleft lip and palate transmembrane 1] -- -- Q9ESL4 Mitogen-activated protein kinase kinase kinase 20 Map3k20 107.9 89.9 76.1 86.3 97 90.7 0.99963503649635 0.997426937172223 -0.000526627142510765 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein binding (GO:0005515),Biological Process:protein phosphorylation (GO:0006468) sterile alpha motif and leucine zipper containing kinase AZK 2.7.11.25 ko04010 MAPK signaling pathway Tyrosine kinase specific for activated (GTP-bound) p21cdc42Hs T Signal transduction mechanisms ; IPR001245 [Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR001660[Sterile alpha motif domain] -- -- O88792 Junctional adhesion molecule A F11r 1183.3 1096.1 1065.5 1273.7 1276.4 1403.3 0.846081853594374 0.0216063920161556 -0.241130852272347 Nonsignificant None -- -- junctional adhesion molecule 1 -- ko04514 Cell adhesion molecules (CAMs) ko04530 Tight junction ko04670 Leukocyte transendothelial migration -- -- -- IPR013106 [Immunoglobulin V-set domain] -- -- Q3UNK1 Aldolase_II domain-containing protein Add3 1151.7 1107.9 1137.8 1529.1 1474.4 1532.5 0.748985890652557 0.0000767467431962105 -0.416989553342605 Nonsignificant None -- -- adducin -- -- Cytoskeletal protein Adducin TZ Signal transduction mechanisms ; Cytoskeleton ; IPR001303 [Class II aldolase/adducin N-terminal] -- -- Q3TJ21 Pyrroline-5-carboxylate reductase Pycr2 1083.5 1000.9 978.9 914.7 970.6 972 1.07209603471809 0.137152072760846 0.100434143301274 Nonsignificant None -- -- pyrroline-5-carboxylate reductase 1.5.1.2 ko00330 Arginine and proline metabolism ko01100 Metabolic pathways ko01230 Biosynthesis of amino acids Pyrroline-5-carboxylate reductase E Amino acid transport and metabolism ; IPR028939 [Pyrroline-5-carboxylate reductase, catalytic, N-terminal] ; IPR029036[Pyrroline-5-carboxylate reductase, dimerisation domain] -- -- Q3UE11 Procollagen-lysine 5-dioxygenase 1723.9 1796.8 1671.9 1504.7 1600.6 1477.7 1.13301331005891 0.0174139649272347 0.180164809298939 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 1.14.11.4 ko00310 Lysine degradation Lysyl hydroxylase O Posttranslational modification, protein turnover, chaperones ; IPR005123 [Oxoglutarate/iron-dependent dioxygenase] -- -- A0A0A0MQ79 Protein PRRC2C Prrc2c 2377.3 2416.9 2026.3 1761.5 1818.9 1748.9 1.27981160752819 0.0168815639071425 0.35593145640634 Nonsignificant None -- -- -- -- -- -- -- -- IPR009738 [BAT2, N-terminal] -- -- Q3TR40 Uncharacterized protein Thbs1 930.9 1327.2 1064.1 782 817 785.3 1.39336492890995 0.113912409103512 0.478573156129179 Nonsignificant None 4 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:protein binding (GO:0005515),Cellular Component:extracellular region (GO:0005576),Biological Process:cell adhesion (GO:0007155) thrombospondin 1 -- ko04015 Rap1 signaling pathway ko04115 p53 signaling pathway ko04145 Phagosome ko04151 PI3K-Akt signaling pathway ko04350 TGF-beta signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko05144 Malaria ko05165 Human papillomavirus infection ko05205 Proteoglycans in cancer ko05206 MicroRNAs in cancer ko05219 Bladder cancer -- -- -- IPR000884 [Thrombospondin type-1 (TSP1) repeat] ; IPR001007[VWFC domain] ; IPR003367[Thrombospondin, type 3-like repeat] ; IPR008859[Thrombospondin, C-terminal] -- -- Q8K3G7 Reticulon Rtn4 37 32.8 45.1 40.9 38.8 35.1 1.00087108013937 0.993731344028673 0.00125615597042538 Nonsignificant None -- -- reticulon-4 -- ko05010 Alzheimer's disease Reticulon U Intracellular trafficking, secretion, and vesicular transport ; IPR003388 [Reticulon] -- -- Q3TIV5 Zinc finger CCCH domain-containing protein 15 Zc3h15 2481.1 2397 2148 2077 2226.6 2150.4 1.08864270220019 0.154910711093092 0.122530532250575 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) -- -- -- Uncharacterized conserved protein, contains CCCH-type Zn-finger R General function prediction only ; IPR000571 [Zinc finger, CCCH-type] ; IPR032378[ZC3H15/TMA46 family, C-terminal] -- -- Q9JKC8 AP-3 complex subunit mu-1 Ap3m1 1134 1170.7 1225.7 1247.6 1241.8 1229.1 0.949415086728519 0.0824775174353865 -0.0748891197192546 Nonsignificant None -- -- AP-3 complex subunit mu -- ko04142 Lysosome Clathrin-associated protein medium chain U Intracellular trafficking, secretion, and vesicular transport ; IPR022775 [AP complex, mu/sigma subunit] ; IPR028565[Mu homology domain] -- -- E9Q804 Ankyrin repeat domain-containing protein 17 Ankrd17 371.4 383.4 386 375.9 381.8 370.6 1.01107861384384 0.493754467109753 0.0158951746824253 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) ankyrin repeat domain-containing protein 17 -- -- FOG: Ankyrin repeat R General function prediction only ; IPR004088 [K Homology domain, type 1] ; IPR020683[Ankyrin repeat-containing domain] -- -- F6XC25 Coiled-coil and C2 domain-containing protein 1B (Fragment) Cc2d1b 1622.5 1573 1532.6 1439.5 1480.5 1571.8 1.05260697270582 0.168744366307025 0.073966856712077 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) coiled-coil and C2 domain-containing protein 1 -- -- Uncharacterized conserved protein, contains DM14 and C2 domains R General function prediction only ; IPR000008 [C2 domain] -- -- Q61102 Iron-sulfur clusters transporter ABCB7, mitochondrial Abcb7 1073.5 991.3 891.3 916.5 931.8 1083.9 1.008150876475 0.920557112304823 0.0117115638910762 Nonsignificant None 5 Molecular Function:ATP binding (GO:0005524),Biological Process:transport (GO:0006810),Cellular Component:integral component of membrane (GO:0016021),Molecular Function:ATPase activity (GO:0016887),Biological Process:transmembrane transport (GO:0055085) ATP-binding cassette, subfamily B (MDR/TAP), member 7 -- ko02010 ABC transporters Mitochondrial Fe/S cluster exporter, ABC superfamily U Intracellular trafficking, secretion, and vesicular transport ; IPR003439 [ABC transporter-like] ; IPR011527[ABC transporter type 1, transmembrane domain] -- -- H3BJG4 Thyroid hormone receptor interactor 11 (Fragment) Trip11 2760.6 2842.1 2784.6 2528.2 2657.4 2652 1.07013626620394 0.0196437123109334 0.0977945144391944 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- B2RV77 Cystatin domain-containing 4 Cstdc4 4513.7 5918.1 2881.6 1707.8 1642.8 1671.2 2.65112111195189 0.0876488579291016 1.406602578776 Nonsignificant None 1 Molecular Function:cysteine-type endopeptidase inhibitor activity (GO:0004869) -- -- -- -- -- -- IPR000010 [Cystatin domain] -- -- Q3UD58 Uncharacterized protein Txlna 1469.2 1525.3 1575.2 1513.2 1569 1522.1 0.992485285493995 0.759415718960489 -0.01088238175238 Nonsignificant None 1 Molecular Function:syntaxin binding (GO:0019905) -- -- -- Myosin-like coiled-coil protein Z Cytoskeleton ; IPR026183 [Taxilin family] -- -- Q61133 Glutathione S-transferase theta-2 Gstt2 1056.2 1011.6 1073.2 1180.1 1186.6 1274.9 0.862532952548331 0.00945887752494781 -0.213348519767255 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) glutathione S-transferase 2.5.1.18 ko00480 Glutathione metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko01524 Platinum drug resistance ko05200 Pathways in cancer ko05204 Chemical carcinogenesis ko05225 Hepatocellular carcinoma ko05418 Fluid shear stress and atherosclerosis Glutathione S-transferase O Posttranslational modification, protein turnover, chaperones ; IPR004045 [Glutathione S-transferase, N-terminal] ; IPR004046[Glutathione S-transferase, C-terminal] -- -- Q8CH18 Cell division cycle and apoptosis regulator protein 1 Ccar1 2297.8 2121.1 2092.8 2101.4 2183 2186.5 1.00630515075183 0.855227619505257 0.00906785257961795 Nonsignificant None -- -- -- -- -- Predicted DNA-binding protein, contains SAP domain R General function prediction only ; IPR003034 [SAP domain] ; IPR025223[S1-like RNA binding domain] ; IPR025954[DBC1/CARP1 catalytically inactive NUDIX hydrolase domain] -- -- A2AA71 Protein transport protein Sec24A Sec24a 50 51.5 60.4 63.1 57.2 57.1 0.912626832018038 0.245930163706274 -0.131903023998498 Nonsignificant None 4 Biological Process:intracellular protein transport (GO:0006886),Biological Process:ER to Golgi vesicle-mediated transport (GO:0006888),Molecular Function:zinc ion binding (GO:0008270),Cellular Component:COPII vesicle coat (GO:0030127) protein transport protein SEC24 -- ko04141 Protein processing in endoplasmic reticulum Vesicle coat complex COPII, subunit SEC24/subunit SFB2 U Intracellular trafficking, secretion, and vesicular transport ; IPR006895 [Zinc finger, Sec23/Sec24-type] ; IPR006896[Sec23/Sec24, trunk domain] ; IPR006900[Sec23/Sec24, helical domain] ; IPR007123[Gelsolin-like domain] ; IPR012990[Sec23/Sec24 beta-sandwich] -- -- Q4FJX8 Proteasome subunit beta Psmb10 2150.6 2242.6 2440.4 2070.9 2282.7 2174.9 1.04673355288351 0.38805926499333 0.0658942494755756 Nonsignificant None 3 Molecular Function:threonine-type endopeptidase activity (GO:0004298),Cellular Component:proteasome core complex (GO:0005839),Biological Process:proteolysis involved in cellular protein catabolic process (GO:0051603) 20S proteasome subunit beta 10 3.4.25.1 ko03050 Proteasome 20S proteasome, regulatory subunit beta type PSMB7/PSMB10/PUP1 O Posttranslational modification, protein turnover, chaperones ; IPR001353 [Proteasome, subunit alpha/beta] ; IPR024689[Proteasome beta subunit, C-terminal] -- -- O54950 5-AMP-activated protein kinase subunit gamma-1 Prkag1 1368.1 1251.3 1191.6 1370.3 1499.1 1622.8 0.848359378478251 0.0640740926965577 -0.237252552131837 Nonsignificant None -- -- 5'-AMP-activated protein kinase, regulatory gamma subunit -- ko04068 FoxO signaling pathway ko04152 AMPK signaling pathway ko04211 Longevity regulating pathway ko04213 Longevity regulating pathway - multiple species ko04371 Apelin signaling pathway ko04530 Tight junction ko04710 Circadian rhythm ko04910 Insulin signaling pathway ko04920 Adipocytokine signaling pathway ko04921 Oxytocin signaling pathway ko04922 Glucagon signaling pathway ko04931 Insulin resistance ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05410 Hypertrophic cardiomyopathy (HCM) 5'-AMP-activated protein kinase, gamma subunit C Energy production and conversion ; IPR000644 [CBS domain] -- -- Q9CR35 Chymotrypsinogen B Ctrb1 1384.7 869 840.7 758.7 1679.8 803.3 0.95453143315442 0.894582098602355 -0.0671353878717471 Nonsignificant None 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) chymotrypsin 3.4.21.1 -- Trypsin E Amino acid transport and metabolism ; IPR001254 [Serine proteases, trypsin domain] -- -- Q9CSH3 Exosome complex exonuclease RRP44 Dis3 1573.1 1640.3 1712 1544.2 1518.4 1577.9 1.06139424630966 0.0951930576667408 0.0859606332073582 Nonsignificant None -- -- exosome complex exonuclease DIS3/RRP44 3.1.13.- ko03018 RNA degradation Exosomal 3'-5' exoribonuclease complex, subunit Rrp44/Dis3 J Translation, ribosomal structure and biogenesis ; IPR002716 [PIN domain] ; IPR033770[Exosome complex exonuclease RRP44, S1 domain] ; IPR033771[Rrp44-like cold shock domain] -- -- P70419 Polypeptide N-acetylgalactosaminyltransferase 3 Galnt3 1447 1377.2 1345.7 1270.2 1273.3 1304.7 1.08359752611611 0.0282518165334987 0.115829004942617 Nonsignificant None -- -- polypeptide N-acetylgalactosaminyltransferase 2.4.1.41 ko00512 Mucin type O-glycan biosynthesis ko01100 Metabolic pathways Polypeptide N-acetylgalactosaminyltransferase O Posttranslational modification, protein turnover, chaperones ; IPR000772 [Ricin B, lectin domain] ; IPR001173[Glycosyltransferase 2-like] -- -- P14115 60S ribosomal protein L27a Rpl27a 5907.9 5951.4 6011.9 5143.7 5206 4662.3 1.19046096456168 0.00545514317734536 0.251520315142831 Nonsignificant None -- -- large subunit ribosomal protein L27Ae -- ko03010 Ribosome 60s ribosomal protein L15/L27 J Translation, ribosomal structure and biogenesis ; IPR021131 [Ribosomal protein L18e/L15P] -- -- Q99J29 Carboxypeptidase Scpep1 2366.6 2157.9 2830.5 2832.3 2931 2832.9 0.855610618645448 0.109227536496859 -0.224973707554968 Nonsignificant None 2 Molecular Function:serine-type carboxypeptidase activity (GO:0004185),Biological Process:proteolysis (GO:0006508) serine carboxypeptidase 1 3.4.16.- -- Serine carboxypeptidases O Posttranslational modification, protein turnover, chaperones ; IPR001563 [Peptidase S10, serine carboxypeptidase] -- -- F8VPK0 Tetratricopeptide repeat domain 37 Ttc37 1469.3 1442.6 1505.9 1470.7 1484.9 1393.1 1.01588980614896 0.534364819037842 0.0227439210626315 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) superkiller protein 3 -- ko03018 RNA degradation TPR repeat-containing protein A RNA processing and modification ; IPR019734 [Tetratricopeptide repeat] -- -- P30412 Peptidyl-prolyl cis-trans isomerase C Ppic 1528.9 1538.1 1638.1 1663.4 1657.3 1594 0.957352432498423 0.166860174949468 -0.0628779695310436 Nonsignificant None 3 Biological Process:protein peptidyl-prolyl isomerization (GO:0000413),Molecular Function:peptidyl-prolyl cis-trans isomerase activity (GO:0003755),Biological Process:protein folding (GO:0006457) peptidyl-prolyl isomerase C (cyclophilin C) 5.2.1.8 -- Peptidyl-prolyl cis-trans isomerase O Posttranslational modification, protein turnover, chaperones ; IPR002130 [Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain] -- -- Q3V141 Polynucleotide adenylyltransferase (Fragment) Papola 1481.2 1439.6 1295.7 1215.9 1326.3 1268.7 1.10643155160198 0.104531145171573 0.145914202861602 Nonsignificant None 4 Molecular Function:RNA binding (GO:0003723),Molecular Function:polynucleotide adenylyltransferase activity (GO:0004652),Molecular Function:nucleotidyltransferase activity (GO:0016779),Biological Process:RNA polyadenylation (GO:0043631) poly(A) polymerase 2.7.7.19 ko03015 mRNA surveillance pathway Poly(A) polymerase and related nucleotidyltransferases A RNA processing and modification ; IPR002934 [Polymerase, nucleotidyl transferase domain] ; IPR007010[Poly(A) polymerase, RNA-binding domain] ; IPR007012[Poly(A) polymerase, central domain] -- -- Q8VDK1 Deaminated glutathione amidase Nit1 1315.9 1304.7 1469.9 1676.7 1653.8 1555.2 0.837239290173363 0.0151542040886993 -0.256288078553879 Nonsignificant None 1 Biological Process:nitrogen compound metabolic process (GO:0006807) Carbon-nitrogen hydrolase E Amino acid transport and metabolism ; IPR003010 [Carbon-nitrogen hydrolase] -- -- Z4YJT3 La-related protein 1 Larp1 2536.4 2659 2217.3 1903.4 1924.1 1957.5 1.28136560069144 0.052278074002099 0.357682165805222 Nonsignificant None -- -- la-related protein 1 -- -- RNA-binding protein LARP/SRO9 and related La domain proteins OJ Posttranslational modification, protein turnover, chaperones ; Translation, ribosomal structure and biogenesis ; IPR006630 [RNA-binding protein Lupus La] -- -- Q6PFA2 Clathrin light chain Clta 1742.2 1768.8 1881.2 1957.9 1982.3 1890.3 0.924826344224338 0.0449699922706088 -0.112745600443579 Nonsignificant None 5 Molecular Function:structural molecule activity (GO:0005198),Biological Process:intracellular protein transport (GO:0006886),Biological Process:vesicle-mediated transport (GO:0016192),Cellular Component:clathrin coat of trans-Golgi network vesicle (GO:0030130),Cellular Component:clathrin coat of coated pit (GO:0030132) clathrin light chain A -- ko04142 Lysosome ko04144 Endocytosis ko04721 Synaptic vesicle cycle ko04961 Endocrine and other factor-regulated calcium reabsorption ko05016 Huntington's disease ko05100 Bacterial invasion of epithelial cells Vesicle coat protein clathrin, light chain U Intracellular trafficking, secretion, and vesicular transport ; IPR000996 [Clathrin light chain] -- -- Q3UYM1 Uncharacterized protein Nub1 1696.6 1612.7 1615.8 1638.8 1599.7 1667.1 1.00397504892368 0.856477495116889 0.00572341546261868 Nonsignificant None -- -- -- -- -- Adaptor protein NUB1, contains UBA domain OT Posttranslational modification, protein turnover, chaperones ; Signal transduction mechanisms ; IPR015940 [Ubiquitin-associated domain] -- -- Q5VM59 Protein S100 S100g 201.1 239.8 1585.6 411.9 292.9 454.7 1.7477360931436 0.591098295359337 0.805487355400837 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) S100 calcium binding protein G -- ko04978 Mineral absorption -- -- -- IPR002048 [EF-hand domain] ; IPR013787[S100/CaBP-9k-type, calcium binding, subdomain] -- -- A2A4P3 Predicted gene, 27029 Gm27029 603.5 543.1 573.4 560.7 552 612.8 0.996812518110693 0.94671141845722 -0.00460590884605512 Nonsignificant None 5 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:alanine-tRNA ligase activity (GO:0004813),Molecular Function:ATP binding (GO:0005524),Biological Process:alanyl-tRNA aminoacylation (GO:0006419),Biological Process:tRNA aminoacylation (GO:0043039) misacylated tRNA(Ala) deacylase 3.1.1.- -- Predicted metal-dependent hydrolase, contains AlaS domain R General function prediction only ; IPR012947 [Threonyl/alanyl tRNA synthetase, SAD] ; IPR018164[Alanyl-tRNA synthetase, class IIc, N-terminal] -- -- P12815 Programmed cell death protein 6 Pdcd6 2571.3 2289.8 2395.6 2373.9 2281.3 2459.3 1.01998734977862 0.650190854792779 0.028551259525376 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) -- -- -- Ca2+-binding protein, EF-Hand protein superfamily T Signal transduction mechanisms ; IPR002048 [EF-hand domain] -- -- Q3U2P1 Protein transport protein Sec24A Sec24a 136 165.9 217.3 194 195.6 178.8 0.913441238564391 0.537334108440278 -0.130616171243642 Nonsignificant None 4 Biological Process:intracellular protein transport (GO:0006886),Biological Process:ER to Golgi vesicle-mediated transport (GO:0006888),Molecular Function:zinc ion binding (GO:0008270),Cellular Component:COPII vesicle coat (GO:0030127) protein transport protein SEC24 -- ko04141 Protein processing in endoplasmic reticulum Vesicle coat complex COPII, subunit SEC24/subunit SFB2 U Intracellular trafficking, secretion, and vesicular transport ; IPR006895 [Zinc finger, Sec23/Sec24-type] ; IPR006896[Sec23/Sec24, trunk domain] ; IPR006900[Sec23/Sec24, helical domain] ; IPR007123[Gelsolin-like domain] ; IPR012990[Sec23/Sec24 beta-sandwich] -- -- Q3TK95 Uncharacterized protein Eif4e 2319.5 2303.2 2440.6 2229.2 2201.4 2089.3 1.08334483657725 0.0409363745928878 0.115492536421328 Nonsignificant None 4 Molecular Function:RNA binding (GO:0003723),Molecular Function:translation initiation factor activity (GO:0003743),Cellular Component:cytoplasm (GO:0005737),Biological Process:translational initiation (GO:0006413) translation initiation factor 4E -- ko01521 EGFR tyrosine kinase inhibitor resistance ko03013 RNA transport ko04066 HIF-1 signaling pathway ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04211 Longevity regulating pathway ko04910 Insulin signaling pathway Translation initiation factor 4F, cap-binding subunit (eIF-4E) and related cap-binding proteins J Translation, ribosomal structure and biogenesis ; IPR001040 [Translation Initiation factor eIF- 4e] -- -- Q9CQR6 Serine/threonine-protein phosphatase 6 catalytic subunit Ppp6c 1046.4 1095.1 1054.8 1037.4 1061.5 1120.2 0.992917275014756 0.805022123307527 -0.010254570383996 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) serine/threonine-protein phosphatase 6 catalytic subunit 3.1.3.16 -- Serine/threonine specific protein phosphatase involved in cell cycle control, PP2A-related DT Cell cycle control, cell division, chromosome partitioning ; Signal transduction mechanisms ; IPR004843 [Calcineurin-like phosphoesterase domain, ApaH type] -- -- E9PWP7 Mucin 3, intestinal Muc3 1380.9 1077 1202.9 1663.8 1793.1 1656.3 0.71595087225221 0.00801688193436411 -0.482067500120986 Nonsignificant None -- -- mucin-3/17 -- -- -- -- -- -- -- -- Q3TX45 Uncharacterized protein Apoe 2342.5 2810.6 2344.7 1828.5 1858.1 1830.8 1.35893718055606 0.0508723759081318 0.442478766337116 Nonsignificant None 4 Cellular Component:extracellular region (GO:0005576),Biological Process:lipid transport (GO:0006869),Molecular Function:lipid binding (GO:0008289),Biological Process:lipoprotein metabolic process (GO:0042157) apolipoprotein E -- ko04979 Cholesterol metabolism ko05010 Alzheimer's disease -- -- -- IPR000074 [Apolipoprotein A/E] -- -- E9Q3L2 Phosphatidylinositol 4-kinase alpha Pi4ka 360 350.8 388.2 359.6 357.3 375.7 1.00585758740619 0.874289576890178 0.00842605813859895 Nonsignificant None 1 Molecular Function:kinase activity (GO:0016301) phosphatidylinositol 4-kinase A 2.7.1.67 ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system Phosphatidylinositol 4-kinase T Signal transduction mechanisms ; IPR000403 [Phosphatidylinositol 3-/4-kinase, catalytic domain] ; IPR001263[Phosphoinositide 3-kinase, accessory (PIK) domain] -- -- Q91X78 Erlin-1 Erlin1 662.7 641.1 571.5 632.6 656 634.2 0.975296442687747 0.608510446965291 -0.0360873002379126 Nonsignificant None -- -- -- -- -- Prohibitin-related membrane protease subunits R General function prediction only ; IPR001107 [Band 7 domain] -- -- Q8BXC0 Prostacyclin synthase Ptgis 785.8 754 775.9 806.4 875.1 857.9 0.911908324801134 0.0302674624179076 -0.133039299009019 Nonsignificant None 3 Molecular Function:iron ion binding (GO:0005506),Molecular Function:heme binding (GO:0020037),Biological Process:oxidation-reduction process (GO:0055114) prostacyclin synthase 5.3.99.4 ko00590 Arachidonic acid metabolism ko01100 Metabolic pathways Cytochrome P450 Q Secondary metabolites biosynthesis, transport and catabolism ; IPR001128 [Cytochrome P450] -- -- Q3TTW4 Aminotran_1_2 domain-containing protein Sptlc1 2139.2 2099.2 2155.2 1627.2 1555 1621.5 1.33097404084352 0.0000494886853651707 0.412482433374866 Nonsignificant None 2 Biological Process:biosynthetic process (GO:0009058),Molecular Function:pyridoxal phosphate binding (GO:0030170) serine palmitoyltransferase 2.3.1.50 ko00600 Sphingolipid metabolism ko01100 Metabolic pathways ko04071 Sphingolipid signaling pathway Serine palmitoyltransferase O Posttranslational modification, protein turnover, chaperones ; IPR004839 [Aminotransferase, class I/classII] -- -- P48024 Eukaryotic translation initiation factor 1 Eif1 554.6 606.7 380.5 389.5 442.5 408.6 1.24278574883121 0.225480162436808 0.313577603115342 Nonsignificant None 2 Molecular Function:translation initiation factor activity (GO:0003743),Biological Process:translational initiation (GO:0006413) translation initiation factor 1 -- ko03013 RNA transport Translation initiation factor 1 (eIF-1/SUI1) J Translation, ribosomal structure and biogenesis ; IPR001950 [SUI1 domain] -- -- Q99P31 Hsp70-binding protein 1 Hspbp1 826 1005.9 960 905.3 908.4 992.4 0.994939595880403 0.941919761055443 -0.00731915452662804 Nonsignificant None -- -- hsp70-interacting protein -- ko04141 Protein processing in endoplasmic reticulum Armadillo/beta-catenin-like repeat-containing protein O Posttranslational modification, protein turnover, chaperones ; IPR013918 [Nucleotide exchange factor Fes1] -- -- Q9D0L7 Armadillo repeat-containing protein 10 Armc10 1657.2 1748.6 2216.7 1616.6 1605.6 1650.9 1.15378301286655 0.285813008148139 0.206371927886199 Nonsignificant None -- -- -- -- -- -- -- -- IPR006911 [Armadillo repeat-containing domain] -- -- A0A1Y7VMH3 Serine/threonine-protein kinase VRK1 Vrk1 2328.1 2203.7 1751 1649.6 1635.4 1662.9 1.26979122455991 0.126200693103897 0.344591312704624 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) vaccinia related kinase 2.7.11.1 -- Casein kinase (serine/threonine/tyrosine protein kinase) T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- D3YYS6 Monoglyceride lipase Mgll 2028.1 1881.8 2035.1 1933.7 1810.6 1953.7 1.04334854334854 0.286944276137102 0.0612211883091668 Nonsignificant None -- -- acylglycerol lipase 3.1.1.23 ko00561 Glycerolipid metabolism ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04923 Regulation of lipolysis in adipocytes Lysophospholipase I Lipid transport and metabolism ; IPR022742 [Serine aminopeptidase, S33] -- -- P08556 GTPase NRas Nras 434.2 413.1 407.7 457.3 421.2 410 0.974000776096236 0.533365143835767 -0.0380051730214854 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) GTPase NRas -- ko01521 EGFR tyrosine kinase inhibitor resistance ko01522 Endocrine resistance ko04010 MAPK signaling pathway ko04012 ErbB signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04062 Chemokine signaling pathway ko04068 FoxO signaling pathway ko04071 Sphingolipid signaling pathway ko04072 Phospholipase D signaling pathway ko04137 Mitophagy - animal ko04140 Autophagy - animal ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04210 Apoptosis ko04211 Longevity regulating pathway ko04213 Longevity regulating pathway - multiple species ko04218 Cellular senescence ko04360 Axon guidance ko04370 VEGF signaling pathway ko04371 Apelin signaling pathway ko04540 Gap junction ko04550 Signaling pathways regulating pluripotency of stem cells ko04650 Natural killer cell mediated cytotoxicity ko04660 T cell receptor signaling pathway ko04662 B cell receptor signaling pathway ko04664 Fc epsilon RI signaling pathway ko04720 Long-term potentiation ko04722 Neurotrophin signaling pathway ko04725 Cholinergic synapse ko04726 Serotonergic synapse ko04730 Long-term depression ko04810 Regulation of actin cytoskeleton ko04910 Insulin signaling pathway ko04912 GnRH signaling pathway ko04915 Estrogen signaling pathway ko04916 Melanogenesis ko04917 Prolactin signaling pathway ko04919 Thyroid hormone signaling pathway ko04921 Oxytocin signaling pathway ko04926 Relaxin signaling pathway ko04933 AGE-RAGE signaling pathway in diabetic complications ko05034 Alcoholism ko05160 Hepatitis C ko05161 Hepatitis B ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05205 Proteoglycans in cancer ko05206 MicroRNAs in cancer ko05211 Renal cell carcinoma ko05213 Endometrial cancer ko05214 Glioma ko05215 Prostate cancer ko05216 Thyroid cancer ko05218 Melanoma ko05219 Bladder cancer ko05220 Chronic myeloid leukemia ko05221 Acute myeloid leukemia ko05223 Non-small cell lung cancer ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer ko05230 Central carbon metabolism in cancer ko05231 Choline metabolism in cancer Ras-related GTPase R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- Q8BUR4 Dedicator of cytokinesis protein 1 Dock1 1870.2 2082.8 2514.5 2072.7 2119 2091.1 1.02939772076144 0.776412346177656 0.0418004933207709 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) dedicator of cytokinesis protein 1 -- ko04510 Focal adhesion ko04810 Regulation of actin cytoskeleton ko05100 Bacterial invasion of epithelial cells Signaling protein DOCK180 T Signal transduction mechanisms ; IPR001452 [SH3 domain] ; IPR010703[Dedicator of cytokinesis, C-terminal] ; IPR027007[DHR-1 domain] ; IPR032376[Dedicator of cytokinesis, N-terminal domain] -- -- Q3UYC1 Diphosphomevalonate decarboxylase Mvd 1143.6 1168.9 1022.1 1265.7 1465.4 1260.5 0.83540434913318 0.0543636370650102 -0.2594534406654 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) diphosphomevalonate decarboxylase 4.1.1.33 ko00900 Terpenoid backbone biosynthesis ko01100 Metabolic pathways Mevalonate pyrophosphate decarboxylase I Lipid transport and metabolism ; IPR006204 [GHMP kinase N-terminal domain] -- -- Q7TQG1 Pleckstrin homology domain-containing family A member 6 Plekha6 1460.5 1321.4 1414.7 1610.1 1594.9 1720 0.85210152284264 0.0129167517193795 -0.230902765638175 Nonsignificant None -- -- -- -- -- -- -- -- IPR001849 [Pleckstrin homology domain] -- -- P05132 cAMP-dependent protein kinase catalytic subunit alpha Prkaca 682.5 649.6 774 760.6 758.3 816.9 0.901661101121671 0.141364910423074 -0.149342811743682 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) protein kinase A 2.7.11.11 ko01522 Endocrine resistance ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04020 Calcium signaling pathway ko04024 cAMP signaling pathway ko04062 Chemokine signaling pathway ko04114 Oocyte meiosis ko04140 Autophagy - animal ko04211 Longevity regulating pathway ko04213 Longevity regulating pathway - multiple species ko04261 Adrenergic signaling in cardiomyocytes ko04270 Vascular smooth muscle contraction ko04310 Wnt signaling pathway ko04340 Hedgehog signaling pathway ko04371 Apelin signaling pathway ko04530 Tight junction ko04540 Gap junction ko04611 Platelet activation ko04713 Circadian entrainment ko04720 Long-term potentiation ko04723 Retrograde endocannabinoid signaling ko04724 Glutamatergic synapse ko04725 Cholinergic synapse ko04726 Serotonergic synapse ko04727 GABAergic synapse ko04728 Dopaminergic synapse ko04740 Olfactory transduction ko04742 Taste transduction ko04750 Inflammatory mediator regulation of TRP channels ko04910 Insulin signaling pathway ko04911 Insulin secretion ko04912 GnRH signaling pathway ko04913 Ovarian steroidogenesis ko04914 Progesterone-mediated oocyte maturation ko04915 Estrogen signaling pathway ko04916 Melanogenesis ko04918 Thyroid hormone synthesis ko04919 Thyroid hormone signaling pathway ko04921 Oxytocin signaling pathway ko04922 Glucagon signaling pathway ko04923 Regulation of lipolysis in adipocytes ko04924 Renin secretion ko04925 Aldosterone synthesis and secretion ko04926 Relaxin signaling pathway ko04961 Endocrine and other factor-regulated calcium reabsorption ko04962 Vasopressin-regulated water reabsorption ko04970 Salivary secretion ko04971 Gastric acid secretion ko04976 Bile secretion ko05012 Parkinson's disease ko05020 Prion diseases ko05030 Cocaine addiction ko05031 Amphetamine addiction ko05032 Morphine addiction ko05146 Amoebiasis ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05205 Proteoglycans in cancer ko05414 Dilated cardiomyopathy (DCM) cAMP-dependent protein kinase catalytic subunit (PKA) T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q9D379 Epoxide hydrolase 1 Ephx1 2877 2868.8 2661.3 3062.3 3163.4 3224 0.88966845508323 0.0149225887765373 -0.168660295124626 Nonsignificant None -- -- microsomal epoxide hydrolase 3.3.2.9 ko00980 Metabolism of xenobiotics by cytochrome P450 ko04976 Bile secretion ko05204 Chemical carcinogenesis Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) R General function prediction only ; IPR010497 [Epoxide hydrolase, N-terminal] -- -- Q8VDF3 Death-associated protein kinase 2 Dapk2 780.5 779.4 708.6 650.7 700.5 615.8 1.1532791052364 0.0424545782274591 0.205741702072214 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) death-associated protein kinase 2.7.11.1 ko04140 Autophagy - animal ko05200 Pathways in cancer ko05219 Bladder cancer Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- O35598 Disintegrin and metalloproteinase domain-containing protein 10 Adam10 2718.6 2541.8 2698.6 2592.3 2665.5 2698.4 1.00035192679923 0.989078846492735 0.000507633728280786 Nonsignificant None -- -- disintegrin and metalloproteinase domain-containing protein 10 3.4.24.81 ko05010 Alzheimer's disease Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases W Extracellular structures ; IPR001762 [Disintegrin domain] ; IPR002870[Peptidase M12B, propeptide] -- -- Q3TAJ5 Uncharacterized protein Rsl1d1 1442.8 1486.3 1551.5 1406.4 1397.7 1462.5 1.05015703370365 0.130290458583945 0.0706050753258013 Nonsignificant None -- -- ribosome biogenesis protein UTP30 -- -- Uncharacterized conserved protein S Function unknown ; IPR028364 [Ribosomal protein L1/ribosomal biogenesis protein] -- -- P97370 Sodium/potassium-transporting ATPase subunit beta-3 Atp1b3 2080.2 2146.9 2457.1 2060.1 2043.7 2079.3 1.08104348951173 0.286491427986623 0.112424562703331 Nonsignificant None 3 Cellular Component:sodium:potassium-exchanging ATPase complex (GO:0005890),Biological Process:potassium ion transport (GO:0006813),Biological Process:sodium ion transport (GO:0006814) sodium/potassium-transporting ATPase subunit beta -- ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04260 Cardiac muscle contraction ko04261 Adrenergic signaling in cardiomyocytes ko04911 Insulin secretion ko04918 Thyroid hormone synthesis ko04919 Thyroid hormone signaling pathway ko04925 Aldosterone synthesis and secretion ko04960 Aldosterone-regulated sodium reabsorption ko04961 Endocrine and other factor-regulated calcium reabsorption ko04964 Proximal tubule bicarbonate reclamation ko04970 Salivary secretion ko04971 Gastric acid secretion ko04972 Pancreatic secretion ko04973 Carbohydrate digestion and absorption ko04974 Protein digestion and absorption ko04976 Bile secretion ko04978 Mineral absorption Na+/K+ ATPase, beta subunit P Inorganic ion transport and metabolism ; IPR000402 [Sodium/potassium-transporting ATPase subunit beta] -- -- E0CYV0 Protein-L-isoaspartate O-methyltransferase Pcmt1 1417.1 1331.5 1501.5 1553.3 1545.6 1627.9 0.899149530337649 0.0461504335410272 -0.153367036169098 Nonsignificant None -- -- protein-L-isoaspartate(D-aspartate) O-methyltransferase 2.1.1.77 -- Protein-L-isoaspartate(D-aspartate) O-methyltransferase O Posttranslational modification, protein turnover, chaperones ; -- -- -- Q9DBJ3 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 Baiap2l1 2173.3 2025.1 2154.1 2249.4 2150.6 2201.7 0.962252147174213 0.202679504684268 -0.0555131096107886 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Biological Process:plasma membrane organization (GO:0007009) BAI1-associated protein 2-like protein -- -- -- -- -- IPR001452 [SH3 domain] ; IPR013606[IMD/I-BAR domain] -- -- Q2PMY2 Interleukin-18 Il18 1707.6 1445.9 1152.3 1052.2 1129.6 1228.6 1.26254984752522 0.150869354107142 0.336340348939883 Nonsignificant None 4 Molecular Function:cytokine activity (GO:0005125),Cellular Component:extracellular space (GO:0005615),Biological Process:inflammatory response (GO:0006954),Biological Process:immune response (GO:0006955) interleukin 18 -- ko04060 Cytokine-cytokine receptor interaction ko04621 NOD-like receptor signaling pathway ko04623 Cytosolic DNA-sensing pathway ko05132 Salmonella infection ko05134 Legionellosis ko05143 African trypanosomiasis ko05144 Malaria ko05152 Tuberculosis ko05164 Influenza A ko05321 Inflammatory bowel disease (IBD) ko05323 Rheumatoid arthritis -- -- -- IPR000975 [Interleukin-1 family] -- -- Q62087 Serum paraoxonase/lactonase 3 Pon3 1661.5 1559.9 2008.7 2083.1 1886.2 2071 0.865867589358144 0.146298424111189 -0.207781673609583 Nonsignificant None 1 Molecular Function:arylesterase activity (GO:0004064) -- -- -- -- -- IPR002640 [Arylesterase] -- -- Q9D8B3 Charged multivesicular body protein 4b Chmp4b 2592.7 2866.1 2842.3 2684.9 2871 2673.8 1.00867589341045 0.83687001218296 0.0124626837766077 Nonsignificant None 1 Biological Process:vacuolar transport (GO:0007034) charged multivesicular body protein 4 -- ko04144 Endocytosis ko04217 Necroptosis Protein involved in glucose derepression and pre-vacuolar endosome protein sorting U Intracellular trafficking, secretion, and vesicular transport ; IPR005024 [Snf7 family] -- -- Q9CQ54 NADH dehydrogenase [ubiquinone] 1 subunit C2 Ndufc2 1737.4 1714 1949.7 2173.1 2068.2 2221.9 0.835669637331353 0.0155953057561301 -0.258995376002523 Nonsignificant None 2 Cellular Component:mitochondrial inner membrane (GO:0005743),Molecular Function:NADH dehydrogenase (ubiquinone) activity (GO:0008137) NADH dehydrogenase (ubiquinone) 1 subunit C2 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease NADH:ubiquinone oxidoreductase, NDUFC2/B14.5B subunit C Energy production and conversion ; IPR009423 [NADH:ubiquinone oxidoreductase, subunit b14.5b] -- -- E9PZ88 Alpha-mannosidase Man2c1 921 982.6 920.4 1090.5 1226 981.2 0.856354428844346 0.0989678994259792 -0.223720070566983 Nonsignificant None 5 Molecular Function:alpha-mannosidase activity (GO:0004559),Biological Process:carbohydrate metabolic process (GO:0005975),Biological Process:mannose metabolic process (GO:0006013),Molecular Function:zinc ion binding (GO:0008270),Molecular Function:mannosidase activity (GO:0015923) alpha-mannosidase 3.2.1.24 ko00511 Other glycan degradation Alpha-mannosidase G Carbohydrate transport and metabolism ; IPR000602 [Glycoside hydrolase family 38, N-terminal domain] ; IPR011682[Glycosyl hydrolase family 38, C-terminal] ; IPR015341[Glycoside hydrolase family 38, central domain] -- -- Q99KR7 Peptidyl-prolyl cis-trans isomerase F, mitochondrial Ppif 1741.2 1632.2 1926.3 2444.6 2450 2464.2 0.720185356308094 0.0149471512756958 -0.473559829705845 Nonsignificant None 3 Biological Process:protein peptidyl-prolyl isomerization (GO:0000413),Molecular Function:peptidyl-prolyl cis-trans isomerase activity (GO:0003755),Biological Process:protein folding (GO:0006457) peptidyl-prolyl isomerase F (cyclophilin D) 5.2.1.8 ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko05012 Parkinson's disease ko05016 Huntington's disease ko05145 Toxoplasmosis Cyclophilin type peptidyl-prolyl cis-trans isomerase O Posttranslational modification, protein turnover, chaperones ; IPR002130 [Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain] -- -- Q3U8W3 Uncharacterized protein Grn 1245.2 1449.4 1692.8 1823.4 1852.9 1765 0.806314667450793 0.0562261392415624 -0.310585128866575 Nonsignificant None -- -- -- -- -- Epithelin/granulin T Signal transduction mechanisms ; IPR000118 [Granulin] -- -- Q9D7S7 60S ribosomal protein L22-like 1 Rpl22l1 1111.1 1154.6 1074.6 895.1 926.8 864 1.24364272683272 0.00175733865155243 0.314572088156021 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L22e -- ko03010 Ribosome 60S ribosomal protein L22 J Translation, ribosomal structure and biogenesis ; IPR002671 [Ribosomal protein L22e] -- -- Q9R0Q6 Actin-related protein 2/3 complex subunit 1A Arpc1a 2399.7 2445.1 2370.6 2293.6 2222 2349.9 1.05096496977642 0.0530240350027826 0.0717145829327409 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) actin related protein 2/3 complex, subunit 1A/1B -- ko04144 Endocytosis ko04666 Fc gamma R-mediated phagocytosis ko04810 Regulation of actin cytoskeleton ko05100 Bacterial invasion of epithelial cells ko05132 Salmonella infection Actin-related protein Arp2/3 complex, subunit ARPC1/p41-ARC Z Cytoskeleton ; IPR001680 [WD40 repeat] -- -- Q6NSR8 Probable aminopeptidase NPEPL1 Npepl1 932.2 909 1079.2 1152.4 1099.8 1154.8 0.857176401526269 0.0448064021847139 -0.222335962406339 Nonsignificant None 3 Molecular Function:aminopeptidase activity (GO:0004177),Cellular Component:intracellular (GO:0005622),Biological Process:proteolysis (GO:0006508) probable aminopeptidase NPEPL1 3.4.11.- -- Predicted aminopeptidase of the M17 family R General function prediction only ; IPR000819 [Peptidase M17, leucyl aminopeptidase, C-terminal] -- -- Q9D832 DnaJ homolog subfamily B member 4 Dnajb4 1605.9 1627.5 1765.6 2060.9 2000.3 1975.5 0.828101446154356 0.00350958655381344 -0.272120579700426 Nonsignificant None -- -- DnaJ homolog subfamily B member 4 -- -- Molecular chaperone (DnaJ superfamily) O Posttranslational modification, protein turnover, chaperones ; IPR001623 [DnaJ domain] ; IPR002939[Chaperone DnaJ, C-terminal] -- -- Q9ESY9 Gamma-interferon-inducible lysosomal thiol reductase Ifi30 1284.1 1211.2 910.3 1125.5 1152.2 1373.9 0.932632270785409 0.586626393854296 -0.100619744454044 Nonsignificant None -- -- interferon, gamma-inducible protein 30 -- ko04612 Antigen processing and presentation Gamma-interferon inducible lysosomal thiol reductase O Posttranslational modification, protein turnover, chaperones ; IPR004911 [Gamma interferon inducible lysosomal thiol reductase GILT] -- -- Q9D2M8 Ubiquitin-conjugating enzyme E2 variant 2 Ube2v2 1280.9 1333.3 1235 1210.6 1252.3 1294.3 1.0244863195997 0.45700751137062 0.0349007195590741 Nonsignificant None -- -- ubiquitin-conjugating enzyme E2 variant -- Ubiquitin-conjugating enzyme E2 O Posttranslational modification, protein turnover, chaperones ; IPR000608 [Ubiquitin-conjugating enzyme E2] -- -- Q60692 Proteasome subunit beta type-6 Psmb6 1625.5 1867.7 1749.4 1642.1 1608.4 1635.3 1.07302795857383 0.229268469722932 0.101687667119892 Nonsignificant None 3 Molecular Function:threonine-type endopeptidase activity (GO:0004298),Cellular Component:proteasome core complex (GO:0005839),Biological Process:proteolysis involved in cellular protein catabolic process (GO:0051603) 20S proteasome subunit beta 1 3.4.25.1 ko03050 Proteasome 20S proteasome, regulatory subunit beta type PSMB6/PSMB9/PRE3 O Posttranslational modification, protein turnover, chaperones ; IPR001353 [Proteasome, subunit alpha/beta] -- -- Q8JZU2 Tricarboxylate transport protein, mitochondrial Slc25a1 1383.9 1363.3 1804.6 1972.2 1970.5 1978.3 0.768755277824692 0.0865239221804546 -0.379403684812679 Nonsignificant None -- -- solute carrier family 25 (mitochondrial citrate transporter), member 1 -- -- Mitochondrial tricarboxylate/dicarboxylate carrier proteins C Energy production and conversion ; IPR018108 [Mitochondrial substrate/solute carrier] -- -- Q8K363 ATP-dependent RNA helicase DDX18 Ddx18 937.2 990.5 1001.2 849.3 877.9 842.3 1.13987157034443 0.00607407881591143 0.188871284684003 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase DDX18/HAS1 3.6.4.13 -- ATP-dependent RNA helicase pitchoune A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR011545[DEAD/DEAH box helicase domain] ; IPR025313[Domain of unknown function DUF4217] -- -- Q9R1T4 Septin-6 Septin6 338.8 341.4 395.4 375.5 407.2 392.4 0.915326355203812 0.182618548113124 -0.12764187379903 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) septin 6/8/11 -- ko05100 Bacterial invasion of epithelial cells Septins (P-loop GTPases) D Cell cycle control, cell division, chromosome partitioning ; IPR030379 [Septin-type guanine nucleotide-binding (G) domain] -- -- G8JL40 Lysine-specific histone demethylase 1A (Fragment) Kdm1a 656.8 652.2 711.6 660.7 678.2 653.1 1.01435742971888 0.665727742633044 0.0205661052210766 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) lysine-specific histone demethylase 1A 1.-.-.- -- Amine oxidase Q Secondary metabolites biosynthesis, transport and catabolism ; IPR002937 [Amine oxidase] ; IPR007526[SWIRM domain] -- -- P43275 Histone H1.1 H1-1 633.6 629.8 701.7 597.8 558.6 598.9 1.11952372813764 0.0598027740151701 0.162885106219742 Nonsignificant None 4 Cellular Component:nucleosome (GO:0000786),Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634),Biological Process:nucleosome assembly (GO:0006334) histone H1/5 -- -- Histone H1 B Chromatin structure and dynamics ; IPR005818 [Linker histone H1/H5, domain H15] -- -- Q7TMC8 L-fucose kinase Fcsk 1056.7 1059.3 1146.8 1116.6 1085.6 1133.2 0.978233495232956 0.500723412861465 -0.0317492307236619 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) fucokinase 2.7.1.52 ko00051 Fructose and mannose metabolism ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways L-fucose kinase G Carbohydrate transport and metabolism ; IPR006204 [GHMP kinase N-terminal domain] ; IPR012887[L-fucokinase] ; IPR013750[GHMP kinase, C-terminal domain] -- -- Q8R1V4 Transmembrane emp24 domain-containing protein 4 Tmed4 1223.6 1309.3 1786.7 1813.4 1794.2 1700.8 0.813729183934896 0.138702371510908 -0.297379361823233 Nonsignificant None 2 Biological Process:transport (GO:0006810),Cellular Component:integral component of membrane (GO:0016021) p24 family protein alpha -- -- emp24/gp25L/p24 family of membrane trafficking proteins U Intracellular trafficking, secretion, and vesicular transport ; IPR009038 [GOLD domain] -- -- Q9JIH2 Nuclear pore complex protein Nup50 Nup50 2126.1 2116.4 2096.9 1763.6 1873.9 1776.2 1.17099211260321 0.00100663505324155 0.227731358378362 Nonsignificant None 2 Cellular Component:nuclear pore (GO:0005643),Biological Process:intracellular transport (GO:0046907) nuclear pore complex protein Nup50 -- ko03013 RNA transport Nuclear pore complex component NPAP60L/NUP50 U Intracellular trafficking, secretion, and vesicular transport ; IPR000156 [Ran binding domain] ; IPR015007[Nuclear pore complex, NUP2/50/61] -- -- Q9D7S9 Charged multivesicular body protein 5 Chmp5 873 859 783 770.3 768.2 758.3 1.09500174155347 0.119032818737158 0.13093316437307 Nonsignificant None 1 Biological Process:vacuolar transport (GO:0007034) charged multivesicular body protein 5 -- ko04144 Endocytosis ko04217 Necroptosis Protein involved in vacuolar protein sorting U Intracellular trafficking, secretion, and vesicular transport ; IPR005024 [Snf7 family] -- -- F6SFF5 Ubiquinone biosynthesis protein (Fragment) Coq9 1536.6 1548.3 1687.8 2014.3 1904.6 1943.2 0.814162160317975 0.00336919685944256 -0.296611923753579 Nonsignificant None -- -- ubiquinone biosynthesis protein COQ9 -- -- Uncharacterized conserved protein S Function unknown ; IPR013718 [COQ9] -- -- Q9QZB7 Actin-related protein 10 Actr10 1942.2 1917.6 1649.6 1635.8 1571 1710.4 1.12043439355731 0.125028432692397 0.164058175077169 Nonsignificant None -- -- actin-related protein 10 -- -- Actin and related proteins Z Cytoskeleton ; IPR004000 [Actin family] -- -- Q99MR8 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial Mccc1 2178.1 2164 2587.4 2886.2 2646.9 2761.3 0.83544319058642 0.0426607290841908 -0.259386365279228 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) 3-methylcrotonyl-CoA carboxylase alpha subunit 6.4.1.4 ko00280 Valine, leucine and isoleucine degradation ko01100 Metabolic pathways 3-Methylcrotonyl-CoA carboxylase, biotin-containing subunit/Propionyl-CoA carboxylase, alpha chain/Acetyl-CoA carboxylase, biotin carboxylase subunit IE Lipid transport and metabolism ; Amino acid transport and metabolism ; IPR000089 [Biotin/lipoyl attachment] ; IPR005479[Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain] ; IPR005481[Biotin carboxylase-like, N-terminal domain] ; IPR005482[Biotin carboxylase, C-terminal] -- -- Q9CX80 Cytoglobin Cygb 1968.2 1837.1 1945 1912.1 1893.4 1938.2 1.00114908508453 0.961134372423458 0.00165682761725709 Nonsignificant None 2 Molecular Function:oxygen binding (GO:0019825),Molecular Function:heme binding (GO:0020037) cytoglobin -- -- Globins and related hemoproteins C Energy production and conversion ; IPR000971 [Globin] -- -- E9PX59 Sterile alpha motif domain-containing protein 9-like Samd9l 627.4 587.1 655.6 647.2 718.5 671.2 0.918110854730227 0.126469679342913 -0.123259736548884 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q9CQE1 Protein NipSnap homolog 3B Nipsnap3b 1267.4 1175.9 1429 1412.3 1343.8 1415.3 0.928297454092151 0.268158821601549 -0.10734093308796 Nonsignificant None -- -- -- -- -- NIPSNAP1 protein S Function unknown ; IPR012577 [NIPSNAP] -- -- Q9WTS2 Alpha-(1,6)-fucosyltransferase Fut8 1230 1052.7 1175.9 1276.7 1342.5 1302.1 0.882003417234081 0.0507697749945157 -0.181143849516005 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) glycoprotein 6-alpha-L-fucosyltransferase 2.4.1.68 ko00510 N-Glycan biosynthesis ko00533 Glycosaminoglycan biosynthesis - keratan sulfate ko01100 Metabolic pathways ko05202 Transcriptional misregulation in cancer Glycoprotein 6-alpha-L-fucosyltransferase O Posttranslational modification, protein turnover, chaperones ; IPR001452 [SH3 domain] -- -- Q9D2Q8 Protein S100-A14 S100a14 2189.2 2069.3 1723.5 2154.5 2200.7 1937 0.950700867741013 0.556977268156632 -0.0729366176425629 Nonsignificant None -- -- -- -- -- -- -- -- IPR013787 [S100/CaBP-9k-type, calcium binding, subdomain] -- -- Q99JR8 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 Smarcd2 2198.7 2266.5 2242.3 2343.8 2314.6 2255.4 0.97016112702132 0.10335935378679 -0.0437037209381316 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D -- ko05225 Hepatocellular carcinoma SWI/SNF transcription activation complex subunit BK Chromatin structure and dynamics ; Transcription ; IPR003121 [SWIB/MDM2 domain] -- -- A2A841 Protein 4.1 Epb41 1170.3 1166.2 1206.4 1073 1171.9 1105 1.05761366010926 0.113206928618427 0.0808127158884735 Nonsignificant None 5 Molecular Function:actin binding (GO:0003779),Molecular Function:structural molecule activity (GO:0005198),Cellular Component:cytoskeleton (GO:0005856),Molecular Function:cytoskeletal protein binding (GO:0008092),Biological Process:cortical actin cytoskeleton organization (GO:0030866) erythrocyte membrane protein band 4.1 -- -- Erythrocyte membrane protein 4.1 and related proteins of the ERM family R General function prediction only ; IPR007477 [SAB domain] ; IPR008379[Band 4.1, C-terminal] ; IPR014847[FERM adjacent (FA)] ; IPR018979[FERM, N-terminal] ; IPR018980[FERM, C-terminal PH-like domain] ; IPR019748[FERM central domain] -- -- Q91WU0 Carboxylesterase 1F Ces1f 1453 1611.2 1619.7 1926.8 1669.6 1886.9 0.854211879707475 0.0508803215337037 -0.227334132899013 Nonsignificant None -- -- carboxylesterase 1 3.1.1.1 ko00983 Drug metabolism - other enzymes ko01100 Metabolic pathways Carboxylesterase and related proteins R General function prediction only ; IPR002018 [Carboxylesterase, type B] -- -- Q99JY3 GTPase IMAP family member 4 Gimap4 1534.2 1404.3 1251.8 1381.1 1497.6 1460.9 0.965595907456908 0.604137750801446 -0.050508533442455 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) -- -- -- -- -- -- IPR006703 [AIG1-type guanine nucleotide-binding (G) domain] -- -- A0A0B4J1E2 SNW domain-containing protein 1 Snw1 2549.4 2615.9 2256.8 1908.9 1856.8 1962.7 1.29566720201103 0.00785877745116547 0.373695203049473 Nonsignificant None 1 Cellular Component:spliceosomal complex (GO:0005681) SNW domain-containing protein 1 -- ko03040 Spliceosome ko04330 Notch signaling pathway ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis mRNA splicing factor/probable chromatin binding snw family nuclear protein AB RNA processing and modification ; Chromatin structure and dynamics ; IPR004015 [SKI-interacting protein SKIP, SNW domain] -- -- Q91VE0 Long-chain fatty acid transport protein 4 Slc27a4 1263.8 1245.1 1184.7 1267.4 1284.9 1177.5 0.99029438575795 0.782884741265074 -0.0140706346041657 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) solute carrier family 27 (fatty acid transporter), member 1/4 6.2.1.- ko03320 PPAR signaling pathway ko04931 Insulin resistance Very long-chain acyl-CoA synthetase/fatty acid transporter I Lipid transport and metabolism ; IPR000873 [AMP-dependent synthetase/ligase] ; IPR025110[AMP-binding enzyme C-terminal domain] -- -- O88811 Signal transducing adapter molecule 2 Stam2 1112.4 1014.4 1082 1078.1 1164 1078.6 0.966302285662662 0.41094477121028 -0.0494535209335391 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Biological Process:intracellular protein transport (GO:0006886) signal transducing adaptor molecule -- ko04144 Endocytosis ko04630 Jak-STAT signaling pathway Signal transducing adaptor protein STAM/STAM2 T Signal transduction mechanisms ; IPR001452 [SH3 domain] ; IPR002014[VHS domain] ; IPR003903[Ubiquitin interacting motif] -- -- Q5PR72 Phosphodiesterase Pde2a 550.9 562.7 589.6 704.4 652.8 648.1 0.84934922455493 0.00921418236103727 -0.235570230224137 Nonsignificant None 3 Molecular Function:3',5'-cyclic-nucleotide phosphodiesterase activity (GO:0004114),Molecular Function:protein binding (GO:0005515),Biological Process:signal transduction (GO:0007165) cGMP-dependent 3',5'-cyclic phosphodiesterase 3.1.4.17 ko00230 Purine metabolism ko04022 cGMP-PKG signaling pathway ko04740 Olfactory transduction ko04925 Aldosterone synthesis and secretion ko05032 Morphine addiction Cyclic nucleotide phosphodiesterase T Signal transduction mechanisms ; IPR002073 [3'5'-cyclic nucleotide phosphodiesterase, catalytic domain] ; IPR003018[GAF domain] -- -- Q62470 Integrin alpha-3 Itga3 1807.9 1866.6 1855.4 1878.4 1855.7 1814.7 0.996593858131488 0.819831294833965 -0.00492241196620636 Nonsignificant None -- -- integrin alpha 3 -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04640 Hematopoietic cell lineage ko04810 Regulation of actin cytoskeleton ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05222 Small cell lung cancer ko05410 Hypertrophic cardiomyopathy (HCM) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05414 Dilated cardiomyopathy (DCM) Vitronectin receptor, alpha subunit W Extracellular structures ; IPR013517 [FG-GAP repeat] ; IPR013649[Integrin alpha-2] -- -- Q8C0D5 Elongation factor-like GTPase 1 Efl1 1563.8 1481.6 1473.2 1502.2 1629.7 1585.9 0.957776929924965 0.232785163075854 -0.062238409244216 Nonsignificant None -- -- ribosome assembly protein 1 3.6.5.- ko03008 Ribosome biogenesis in eukaryotes Translation elongation factor 2/ribosome biogenesis protein RIA1 and related proteins J Translation, ribosomal structure and biogenesis ; IPR000640 [Translation elongation factor EFG, V domain] ; IPR009022[Elongation factor G, III-V domain] -- -- P18872 Guanine nucleotide-binding protein G(o) subunit alpha Gnao1 595.9 613.8 777 805.6 854.3 803.9 0.806356035392483 0.0567865408017175 -0.310511113354002 Nonsignificant None 5 Molecular Function:GTPase activity (GO:0003924),Molecular Function:signal transducer activity (GO:0004871),Biological Process:G-protein coupled receptor signaling pathway (GO:0007186),Molecular Function:guanyl nucleotide binding (GO:0019001),Molecular Function:G-protein beta/gamma-subunit complex binding (GO:0031683) guanine nucleotide-binding protein G(o) subunit alpha -- ko04015 Rap1 signaling pathway ko04713 Circadian entrainment ko04723 Retrograde endocannabinoid signaling ko04724 Glutamatergic synapse ko04725 Cholinergic synapse ko04726 Serotonergic synapse ko04727 GABAergic synapse ko04728 Dopaminergic synapse ko04730 Long-term depression ko04915 Estrogen signaling pathway ko04916 Melanogenesis ko04921 Oxytocin signaling pathway ko04926 Relaxin signaling pathway ko05032 Morphine addiction ko05034 Alcoholism ko05142 Chagas disease (American trypanosomiasis) ko05145 Toxoplasmosis G-protein alpha subunit (small G protein superfamily) DT Cell cycle control, cell division, chromosome partitioning ; Signal transduction mechanisms ; IPR001019 [Guanine nucleotide binding protein (G-protein), alpha subunit] -- -- O08600 Endonuclease G, mitochondrial Endog 1339.4 1260.3 1325.7 1567.8 1503.7 1517.4 0.855411972368106 0.00209919751872498 -0.225308695534677 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:hydrolase activity (GO:0016787),Molecular Function:metal ion binding (GO:0046872) endonuclease G, mitochondrial -- ko04210 Apoptosis Mitochondrial endonuclease F Nucleotide transport and metabolism ; IPR001604 [DNA/RNA non-specific endonuclease] -- -- Q6PE01 U5 small nuclear ribonucleoprotein 40 kDa protein Snrnp40 1450 1514 1510 1254.5 1290.8 1278.1 1.17016268242925 0.000737966131719781 0.226709115123591 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) Prp8 binding protein -- ko03040 Spliceosome U5 snRNP-specific protein-like factor and related proteins A RNA processing and modification ; IPR001680 [WD40 repeat] -- -- Q61136 Serine/threonine-protein kinase PRP4 homolog Prpf4b 2330.3 2152.5 2148.3 1907.5 1959.1 2212.6 1.0907849717068 0.175045979335621 0.125366728767516 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) serine/threonine-protein kinase PRP4 2.7.11.1 -- U4/U6-associated splicing factor PRP4 A RNA processing and modification ; IPR000719 [Protein kinase domain] -- -- Q9CQ43 Deoxyuridine 5-triphosphate nucleotidohydrolase Dut 914.7 837.2 809.7 776.1 776.9 826.9 1.0763477457036 0.164506137253611 0.106144258145793 Nonsignificant None 2 Molecular Function:hydrolase activity (GO:0016787),Biological Process:dUTP metabolic process (GO:0046080) dUTP pyrophosphatase 3.6.1.23 ko00240 Pyrimidine metabolism ko01100 Metabolic pathways dUTPase F Nucleotide transport and metabolism ; IPR008180 [Deoxyuridine triphosphate nucleotidohydrolase/Deoxycytidine triphosphate deaminase] -- -- O55026 Ectonucleoside triphosphate diphosphohydrolase 2 Entpd2 1460.7 1399.6 1665.8 1970.1 2089.2 2247 0.717710860568003 0.00641819144121118 -0.478525342814813 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) adenosinetriphosphatase 3.6.1.3 ko00230 Purine metabolism ko04742 Taste transduction Nucleoside phosphatase F Nucleotide transport and metabolism ; IPR000407 [Nucleoside phosphatase GDA1/CD39] -- -- Q921W4 Quinone oxidoreductase-like protein 1 Cryzl1 1952.3 1934 1790.8 1915.4 1970.7 1887.6 0.983268960978229 0.599829544982243 -0.0243419930779267 Nonsignificant None 1 Biological Process:oxidation-reduction process (GO:0055114) -- -- -- Zinc-binding oxidoreductase CR Energy production and conversion ; General function prediction only ; IPR013154 [Alcohol dehydrogenase, N-terminal] -- -- O08797 SPI6 Serpinb9 2625.6 2660.3 2940.1 2965.8 3012.5 3058.9 0.910237684238481 0.0586631735433922 -0.135684779138769 Nonsignificant None -- -- serpin B -- ko05146 Amoebiasis Serpin V Defense mechanisms ; IPR023796 [Serpin domain] -- -- P54731 FAS-associated factor 1 Faf1 1778.4 1859.7 1861.5 1788.2 1887.1 1780.6 1.00800967759673 0.756720444225537 0.0115094897840482 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) FAS-associated factor 1 -- ko04217 Necroptosis Predicted regulator of the ubiquitin pathway (contains UAS and UBX domains) T Signal transduction mechanisms ; IPR001012 [UBX domain] -- -- E9Q449 DENN domain-containing protein 4C Dennd4c 856.9 827.4 907.5 962.5 923.7 926.7 0.921397845639731 0.0497731855192002 -0.118103870169147 Nonsignificant None -- -- DENN domain-containing protein 4 -- -- Calmodulin-binding protein CRAG, contains DENN domain T Signal transduction mechanisms ; IPR001194 [DENN domain] ; IPR005112[dDENN domain] ; IPR005113[uDENN domain] -- -- Q9R0E1 Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 Plod3 934.2 926.5 763.8 777.9 824.9 830.4 1.07862074634227 0.333342368016904 0.109187688226136 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00310 Lysine degradation ko00514 Other types of O-glycan biosynthesis Lysyl hydroxylase O Posttranslational modification, protein turnover, chaperones ; IPR005123 [Oxoglutarate/iron-dependent dioxygenase] -- -- Q571D6 MKIAA0281 protein (Fragment) Elmo1 1629 1748.9 1644.7 1407 1335.1 1476.2 1.19066922693976 0.0084314859706433 0.251772681940662 Nonsignificant None -- -- engulfment and cell motility protein 1 -- ko04062 Chemokine signaling pathway ko05100 Bacterial invasion of epithelial cells Regulator of Rac1, required for phagocytosis and cell migration T Signal transduction mechanisms ; IPR001849 [Pleckstrin homology domain] ; IPR006816[ELMO domain] ; IPR024574[Domain of unknown function DUF3361] -- -- E9Q3N9 EGF-containing fibulin-like extracellular matrix protein 2 Efemp2 700.1 736.1 793.8 725.2 718.2 674.3 1.05302922982481 0.301727786306436 0.0745454830284197 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) EGF-containing fibulin-like extracellular matrix protein 2 -- -- Fibrillins and related proteins containing Ca2+-binding EGF-like domains T Signal transduction mechanisms ; IPR001881 [EGF-like calcium-binding domain] ; IPR026823[Complement Clr-like EGF domain] -- -- P70271 PDZ and LIM domain protein 4 Pdlim4 2097.3 2145.9 1787.8 2119.5 2115.3 2039.3 0.961253406863136 0.520365527217205 -0.0570112886208659 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:zinc ion binding (GO:0008270) -- -- -- Adaptor protein Enigma and related PDZ-LIM proteins TZ Signal transduction mechanisms ; Cytoskeleton ; IPR001478 [PDZ domain] ; IPR001781[Zinc finger, LIM-type] ; IPR031847[Domain of unknown function DUF4749] -- -- Q9D9Z4 V-type proton ATPase subunit C Atp6v1c1 703.7 820.3 1178.1 1187.8 1236.7 997.3 0.789672102402244 0.208899231707831 -0.340674371266983 Nonsignificant None 2 Molecular Function:hydrogen ion transmembrane transporter activity (GO:0015078),Biological Process:ATP hydrolysis coupled proton transport (GO:0015991) V-type H+-transporting ATPase subunit C -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04145 Phagosome ko04150 mTOR signaling pathway ko04721 Synaptic vesicle cycle ko04966 Collecting duct acid secretion ko05323 Rheumatoid arthritis Vacuolar H+-ATPase V1 sector, subunit C C Energy production and conversion ; IPR004907 [ATPase, V1 complex, subunit C] -- -- Q5QNU0 Uncharacterized protein Nup88 1460 1478.4 1485.3 1280 1298.9 1280.6 1.14618473895582 0.0000429529542696444 0.19683959252032 Nonsignificant None -- -- nuclear pore complex protein Nup88 -- ko03013 RNA transport Nuclear pore complex, Nup88/rNup84 component YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; IPR019321 [Nucleoporin Nup88] -- -- A0A0G2JFX7 RNA-binding protein 8A Rbm8a 1081.2 974.6 1901.3 1661 1752.6 1644.2 0.782375736486219 0.336436802506294 -0.354066465642456 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) RNA-binding protein 8A -- ko03013 RNA transport ko03015 mRNA surveillance pathway ko03040 Spliceosome RNA-binding protein RBM8/Tsunagi (RRM superfamily) R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- D3Z5I1 Zinc finger CCCH-type antiviral protein 1 Zc3hav1 1240 1189.3 1163 1044.7 1144.5 1171.3 1.06897783067996 0.158643286598662 0.0962319336012171 Nonsignificant None 1 Molecular Function:NAD+ ADP-ribosyltransferase activity (GO:0003950) poly [ADP-ribose] polymerase 7/11/12/13 2.4.2.30 -- -- -- -- IPR004170 [WWE domain] ; IPR012317[Poly(ADP-ribose) polymerase, catalytic domain] -- -- P49443 Protein phosphatase 1A Ppm1a 870.2 929.7 1153.4 1114.1 1145.2 1116.9 0.874740832889047 0.242603870943412 -0.193072454501758 Nonsignificant None 4 Molecular Function:magnesium ion binding (GO:0000287),Molecular Function:catalytic activity (GO:0003824),Molecular Function:phosphoprotein phosphatase activity (GO:0004721),Molecular Function:manganese ion binding (GO:0030145) protein phosphatase 1A 3.1.3.16 ko04010 MAPK signaling pathway Protein phosphatase 1B (formerly 2C) T Signal transduction mechanisms ; IPR001932 [PPM-type phosphatase domain] ; IPR012911[Protein serine/threonine phosphatase 2C, C-terminal] -- -- O55060 Thiopurine S-methyltransferase Tpmt 762.7 703.3 951.2 1253.7 1366.2 1228.6 0.628088865791867 0.00513708298044356 -0.670959400154045 Significant down 1 Molecular Function:S-adenosylmethionine-dependent methyltransferase activity (GO:0008757) thiopurine S-methyltransferase 2.1.1.67 ko00983 Drug metabolism - other enzymes -- -- -- IPR008854 [TPMT family] -- -- Q8K4Z3 NAD(P)H-hydrate epimerase Naxe 1799.9 1785.8 2106 2283.8 2133.9 2128.7 0.869439692044483 0.0702828622318684 -0.201842135217294 Nonsignificant None -- -- NAD(P)H-hydrate epimerase 5.1.99.6 -- Uncharacterized conserved protein S Function unknown ; IPR004443 [YjeF N-terminal domain] -- -- Q6P1J1 Crmp1 protein Crmp1 765.3 692.6 1013.3 907.7 918.2 1024.5 0.866966039854056 0.291049357885502 -0.205952612505662 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) -- -- -- Dihydroorotase and related enzymes F Nucleotide transport and metabolism ; IPR006680 [Amidohydrolase-related] -- -- P97930 Thymidylate kinase Dtymk 1663.7 1578.3 1561.7 1494.3 1451.8 1587 1.0596942489687 0.151124744018956 0.0836480674997556 Nonsignificant None -- -- dTMP kinase 2.7.4.9 ko00240 Pyrimidine metabolism ko01100 Metabolic pathways Thymidylate kinase/adenylate kinase F Nucleotide transport and metabolism ; -- -- -- Q8BMP6 Golgi resident protein GCP60 Acbd3 2536.4 2490.8 2670.3 2573.4 2650.2 2693.9 0.972213451215662 0.318119757012717 -0.0406549999833726 Nonsignificant None 3 Molecular Function:fatty-acyl-CoA binding (GO:0000062),Biological Process:transport (GO:0006810),Cellular Component:integral component of membrane (GO:0016021) -- -- -- Protein involved in maintenance of Golgi structure and ER-Golgi transport U Intracellular trafficking, secretion, and vesicular transport ; IPR000582 [Acyl-CoA-binding protein, ACBP] ; IPR009038[GOLD domain] -- -- O08915 AH receptor-interacting protein Aip 1909.1 1919.3 1818.3 1682 1753 1753.4 1.08833166294041 0.0186730018007043 0.122118276775411 Nonsignificant None -- -- AH receptor-interacting protein -- -- Aryl-hydrocarbon receptor-interacting protein O Posttranslational modification, protein turnover, chaperones ; IPR001179 [FKBP-type peptidyl-prolyl cis-trans isomerase domain] -- -- F8WHY8 Metastasis-associated protein MTA1 Mta1 1056.5 1146.7 1164.7 1001.1 991.8 1005.3 1.12330731772397 0.0645589250610895 0.167752678497338 Nonsignificant None 3 Molecular Function:chromatin binding (GO:0003682),Molecular Function:zinc ion binding (GO:0008270),Molecular Function:sequence-specific DNA binding (GO:0043565) metastasis-associated protein MTA -- -- Histone deacetylase complex, MTA1 component B Chromatin structure and dynamics ; IPR000679 [Zinc finger, GATA-type] ; IPR000949[ELM2 domain] ; IPR001005[SANT/Myb domain] ; IPR001025[Bromo adjacent homology (BAH) domain] -- zf-GATA Q9D1E6 Tubulin-folding cofactor B Tbcb 2903.7 2885.5 2947.6 2671.3 2653.9 2633.9 1.0977120528703 0.000264721561546395 0.134499662378741 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) tubulin-folding cofactor B -- -- Alpha-tubulin folding cofactor B O Posttranslational modification, protein turnover, chaperones ; IPR000626 [Ubiquitin domain] ; IPR000938[CAP Gly-rich domain] -- -- P52479 Ubiquitin carboxyl-terminal hydrolase 10 Usp10 1335.8 1319.8 1404 1166.4 1197.9 1195.4 1.14043318257157 0.00385850400046627 0.189581922321664 Nonsignificant None 2 Biological Process:protein deubiquitination (GO:0016579),Molecular Function:thiol-dependent ubiquitinyl hydrolase activity (GO:0036459) ubiquitin carboxyl-terminal hydrolase 10 3.4.19.12 Ubiquitin-specific protease O Posttranslational modification, protein turnover, chaperones ; IPR001394 [Peptidase C19, ubiquitin carboxyl-terminal hydrolase] ; IPR009818[Ataxin-2, C-terminal] -- -- E9PYX1 Harmonin Ush1c 2323.8 2131.8 2678.8 2541.6 2482 2478.2 0.951025087312379 0.525330252283307 -0.0724446961109061 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) harmonin -- -- FOG: PDZ domain S Function unknown ; IPR001478 [PDZ domain] -- -- Q8BIL5 Protein Hook homolog 1 Hook1 1820 1698 1752.4 1660.4 1703.3 1759.1 1.02881236823612 0.339497886509688 0.0409798917575602 Nonsignificant None -- -- protein HOOK1 -- -- -- -- -- IPR008636 [Hook-related protein family] -- -- Q6P4S8 Integrator complex subunit 1 Ints1 636.5 647.4 585 556.6 581.1 601.4 1.07463630613536 0.135560115340956 0.10384848482585 Nonsignificant None -- -- integrator complex subunit 1 -- -- Uncharacterized conserved protein S Function unknown ; IPR022145 [Domain of unknown function DUF3677] -- -- Q6ZWZ4 60S ribosomal protein L36 Rpl36 2450.2 2562.4 2242 2222.5 2195.7 2168.8 1.10135114619705 0.0794573505902355 0.139274519863988 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L36e -- ko03010 Ribosome 60S ribosomal protein L36 J Translation, ribosomal structure and biogenesis ; IPR000509 [Ribosomal protein L36e] -- -- Q62150 RNA-binding protein with serine-rich domain 1 Rnps1 1298.6 1237.9 1214.1 1146.7 1188.5 1167.2 1.07086569209685 0.0413385694813369 0.0987775487190369 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) RNA-binding protein with serine-rich domain 1 -- ko03013 RNA transport ko03015 mRNA surveillance pathway Splicing factor RNPS1, SR protein superfamily A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- D3Z5G7 Carboxylic ester hydrolase Ces1b 229.1 229.7 148.9 155.1 145.2 107.5 1.49019127023051 0.0942592784743459 0.575497516528463 Nonsignificant None -- -- -- -- -- Carboxylesterase and related proteins R General function prediction only ; IPR002018 [Carboxylesterase, type B] -- -- O70310 Glycylpeptide N-tetradecanoyltransferase 1 Nmt1 874.6 841.4 841.6 771 750.9 783 1.10963599288472 0.00433826256388096 0.15008648974074 Nonsignificant None 1 Molecular Function:glycylpeptide N-tetradecanoyltransferase activity (GO:0004379) glycylpeptide N-tetradecanoyltransferase 2.3.1.97 -- N-myristoyl transferase I Lipid transport and metabolism ; IPR022676 [Myristoyl-CoA:protein N-myristoyltransferase, N-terminal] ; IPR022677[Myristoyl-CoA:protein N-myristoyltransferase, C-terminal] -- -- Q9CQZ5 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 Ndufa6 1730.8 1558.9 1515.3 1747.7 1672.6 1909.2 0.901585514588611 0.1424124920353 -0.149463758391266 Nonsignificant None -- -- NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 6 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease NADH:ubiquinone oxidoreductase, NDUFA6/B14 subunit C Energy production and conversion ; IPR008011 [Complex 1 LYR protein] -- -- P70696 Histone H2B type 1-A H2bc1 618.8 478.7 444 436.8 450.4 552.3 1.07085793678361 0.626898784259046 0.0987671005437405 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) histone H2B -- ko05034 Alcoholism ko05203 Viral carcinogenesis ko05322 Systemic lupus erythematosus Histone H2B B Chromatin structure and dynamics ; IPR007125 [Histone H2A/H2B/H3] -- -- Q91XG5 Protein S100 S100g 79.3 117.6 1359.5 293.1 164.9 352.9 1.91934887162412 0.615500128251836 0.940616967717005 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) S100 calcium binding protein G -- ko04978 Mineral absorption -- -- -- IPR002048 [EF-hand domain] ; IPR013787[S100/CaBP-9k-type, calcium binding, subdomain] -- -- Q8VI89 Kinesin superfamily protein 1C Kif1c 477.8 492.3 461 515.5 525.3 494.1 0.932373444524073 0.0552128479528331 -0.101020180080609 Nonsignificant None 4 Molecular Function:microtubule motor activity (GO:0003777),Molecular Function:ATP binding (GO:0005524),Biological Process:microtubule-based movement (GO:0007018),Molecular Function:microtubule binding (GO:0008017) kinesin family member 1 -- -- Kinesin-like protein Z Cytoskeleton ; IPR001752 [Kinesin motor domain] ; IPR032405[Kinesin-associated] -- -- Q3TVI8 Pre-B-cell leukemia transcription factor-interacting protein 1 Pbxip1 1774.3 1799.6 1877.9 2105.7 2124.7 2355 0.82786163331005 0.0117365367593742 -0.272538435397731 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q8VIB3 Type 2 lactosamine alpha-2,3-sialyltransferase St3gal6 1096.4 997.4 898.2 1435.7 1461.5 1615.2 0.663061785302721 0.00319072272999051 -0.592784785338765 Significant down 2 Biological Process:protein glycosylation (GO:0006486),Molecular Function:sialyltransferase activity (GO:0008373) neolactotetraosylceramide alpha-2,3-sialyltransferase (sialyltransferase 10) 2.4.99.6 ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series ko01100 Metabolic pathways Sialyltransferase G Carbohydrate transport and metabolism ; IPR001675 [Glycosyl transferase family 29] -- -- Q545V8 Protein kinase domain-containing protein Csnk2a2 1248.8 1257.8 1207.5 1172.3 1173 1198.9 1.04793747531178 0.0334155986010338 0.067552641733598 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) casein kinase II subunit alpha 2.7.11.1 ko03008 Ribosome biogenesis in eukaryotes ko04064 NF-kappa B signaling pathway ko04137 Mitophagy - animal ko04310 Wnt signaling pathway ko04520 Adherens junction ko05162 Measles ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection Casein kinase II, alpha subunit TDK Signal transduction mechanisms ; Cell cycle control, cell division, chromosome partitioning ; Transcription ; IPR000719 [Protein kinase domain] -- -- Q8CC86 Nicotinate phosphoribosyltransferase Naprt 916.1 879.2 1065.2 1138.3 1170.4 1184.9 0.818782917334555 0.0226087334459288 -0.28844709185898 Nonsignificant None -- -- nicotinate phosphoribosyltransferase 6.3.4.21 ko00760 Nicotinate and nicotinamide metabolism ko01100 Metabolic pathways Nicotinic acid phosphoribosyltransferase H Coenzyme transport and metabolism ; -- -- -- Q01514 Guanylate-binding protein 1 Gbp1 342.9 326 307.7 506.6 756.6 645.5 0.511657148844763 0.0476717523861532 -0.966750681820503 Significant down 2 Molecular Function:GTPase activity (GO:0003924),Molecular Function:GTP binding (GO:0005525) guanylate-binding protein 1/3/4/7 -- ko04621 NOD-like receptor signaling pathway Guanylate-binding protein R General function prediction only ; IPR003191 [Guanylate-binding protein, C-terminal] ; IPR015894[Guanylate-binding protein, N-terminal] -- -- Q9CYA0 Protein disulfide isomerase Creld2 Creld2 1684.3 1611.1 1629.3 1448.3 1588.5 1421.3 1.10466342163702 0.0507163375796506 0.143606863822166 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR001881 [EGF-like calcium-binding domain] ; IPR021852[Domain of unknown function DUF3456] -- -- Q2EMV9 Protein mono-ADP-ribosyltransferase PARP14 Parp14 1957.3 2140 2218.6 2052.2 2412.5 2059 0.968146910495578 0.651097849678323 -0.0467021104435216 Nonsignificant None 1 Molecular Function:NAD+ ADP-ribosyltransferase activity (GO:0003950) poly [ADP-ribose] polymerase 10/14/15 2.4.2.30 -- -- -- -- IPR002589 [Macro domain] ; IPR012317[Poly(ADP-ribose) polymerase, catalytic domain] -- -- A0A1L1SQA8 40S ribosomal protein S25 Rps25 5277.7 5358.3 4605.4 3907.5 4044.9 4002.8 1.27487620449679 0.0106220720400261 0.350357162511875 Nonsignificant None -- -- small subunit ribosomal protein S25e -- ko03010 Ribosome 40S ribosomal protein S25 J Translation, ribosomal structure and biogenesis ; IPR004977 [Ribosomal protein S25] -- -- Q4FK57 Ero1l protein Ero1a 1514.6 1526.7 1825.7 1519.1 1626 1442.7 1.06085705566938 0.46299782093543 0.0852302745655005 Nonsignificant None 3 Molecular Function:protein disulfide isomerase activity (GO:0003756),Cellular Component:endoplasmic reticulum (GO:0005783),Biological Process:oxidation-reduction process (GO:0055114) ERO1-like protein alpha 1.8.4.- ko04141 Protein processing in endoplasmic reticulum Endoplasmic reticulum membrane-associated oxidoreductin involved in disulfide bond formation OU Posttranslational modification, protein turnover, chaperones ; Intracellular trafficking, secretion, and vesicular transport ; IPR007266 [Endoplasmic reticulum oxidoreductin 1] -- -- Q9CXZ1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial Ndufs4 1617.4 1681.3 1856.8 2179.6 2031 2315.2 0.790018082074229 0.0137546558970812 -0.340042420559299 Nonsignificant None 1 Biological Process:electron transport chain (GO:0022900) NADH dehydrogenase (ubiquinone) Fe-S protein 4 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease NADH:ubiquinone oxidoreductase, NDUFS4/18 kDa subunit C Energy production and conversion ; IPR006885 [NADH dehydrogenase ubiquinone Fe-S protein 4, mitochondrial] -- -- Q3TPL4 Uncharacterized protein Capn5 1062.3 1078.7 1137.5 1364.4 1430.4 1348.5 0.791277484131007 0.00105012452490932 -0.337744389090929 Nonsignificant None 3 Molecular Function:calcium-dependent cysteine-type endopeptidase activity (GO:0004198),Cellular Component:intracellular (GO:0005622),Biological Process:proteolysis (GO:0006508) calpain-5 3.4.22.- -- Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) OT Posttranslational modification, protein turnover, chaperones ; Signal transduction mechanisms ; IPR001300 [Peptidase C2, calpain, catalytic domain] ; IPR022682[Peptidase C2, calpain, large subunit, domain III] -- -- Q8CBW3 Abl interactor 1 Abi1 2530.5 2623.4 2746.4 2830 2873.2 2883.5 0.920062422117927 0.0240203812691861 -0.120196349994935 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:cytoplasm (GO:0005737) -- -- -- Abl interactor ABI-1, contains SH3 domain TZ Signal transduction mechanisms ; Cytoskeleton ; IPR001452 [SH3 domain] ; IPR012849[Abl-interactor, homeo-domain homologous domain] -- -- A0A0R4J0P1 Isobutyryl-CoA dehydrogenase, mitochondrial Acad8 1888.9 1753.4 2113.1 2546.5 2347.5 2566.4 0.771459975336443 0.0107453976540172 -0.37433678563706 Nonsignificant None 4 Molecular Function:acyl-CoA dehydrogenase activity (GO:0003995),Biological Process:metabolic process (GO:0008152),Molecular Function:flavin adenine dinucleotide binding (GO:0050660),Biological Process:oxidation-reduction process (GO:0055114) isobutyryl-CoA dehydrogenase 1.3.99.- ko00280 Valine, leucine and isoleucine degradation ko01100 Metabolic pathways Medium-chain acyl-CoA dehydrogenase I Lipid transport and metabolism ; IPR006091 [Acyl-CoA oxidase/dehydrogenase, central domain] ; IPR009075[Acyl-CoA dehydrogenase/oxidase C-terminal] ; IPR013786[Acyl-CoA dehydrogenase/oxidase, N-terminal] -- -- Q3U5I5 Uncharacterized protein Grb2 3391.9 3375.9 3060.8 2942.8 3096 2905.3 1.09889200702139 0.0739174931673419 0.136049613229759 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) growth factor receptor-binding protein 2 -- ko01521 EGFR tyrosine kinase inhibitor resistance ko01522 Endocrine resistance ko04010 MAPK signaling pathway ko04012 ErbB signaling pathway ko04014 Ras signaling pathway ko04062 Chemokine signaling pathway ko04068 FoxO signaling pathway ko04072 Phospholipase D signaling pathway ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04380 Osteoclast differentiation ko04510 Focal adhesion ko04540 Gap junction ko04550 Signaling pathways regulating pluripotency of stem cells ko04630 Jak-STAT signaling pathway ko04650 Natural killer cell mediated cytotoxicity ko04660 T cell receptor signaling pathway ko04662 B cell receptor signaling pathway ko04664 Fc epsilon RI signaling pathway ko04722 Neurotrophin signaling pathway ko04910 Insulin signaling pathway ko04912 GnRH signaling pathway ko04915 Estrogen signaling pathway ko04917 Prolactin signaling pathway ko04926 Relaxin signaling pathway ko05034 Alcoholism ko05160 Hepatitis C ko05161 Hepatitis B ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05205 Proteoglycans in cancer ko05206 MicroRNAs in cancer ko05211 Renal cell carcinoma ko05213 Endometrial cancer ko05214 Glioma ko05215 Prostate cancer ko05220 Chronic myeloid leukemia ko05221 Acute myeloid leukemia ko05223 Non-small cell lung cancer ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer ko05231 Choline metabolism in cancer Adaptor protein GRB2, contains SH2 and SH3 domains T Signal transduction mechanisms ; IPR000980 [SH2 domain] ; IPR001452[SH3 domain] -- -- Q9CQJ8 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 Ndufb9 656.3 623.4 679.5 866.6 819.2 898.2 0.758204334365325 0.0017779436500129 -0.399341391017309 Nonsignificant None -- -- NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 9 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease NADH:ubiquinone oxidoreductase, NDUFB9/B22 subunit C Energy production and conversion ; IPR008011 [Complex 1 LYR protein] -- -- P11440 Cyclin-dependent kinase 1 Cdk1 1832.6 1879.6 2114.2 1376.9 1444.8 1328.7 1.40381649961449 0.00392381398947724 0.489354365558508 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) -- -- ko04110 Cell cycle ko04114 Oocyte meiosis ko04115 p53 signaling pathway ko04218 Cellular senescence ko04540 Gap junction ko04914 Progesterone-mediated oocyte maturation ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis Protein kinase PCTAIRE and related kinases R General function prediction only ; IPR000719 [Protein kinase domain] -- -- Q9ESU1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 Smarcb1 1246.5 1254.3 1322.4 1204.7 1304.4 1183.6 1.03533999512552 0.382405817943933 0.0501046119116187 Nonsignificant None 2 Cellular Component:nuclear chromosome (GO:0000228),Biological Process:chromatin remodeling (GO:0006338) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 -- ko05225 Hepatocellular carcinoma SWI-SNF chromatin remodeling complex, Snf5 subunit BK Chromatin structure and dynamics ; Transcription ; IPR006939 [SNF5/SMARCB1/INI1] -- -- Q8VCM8 Nicalin Ncln 2130.2 2163.8 2065.6 1863.1 2017 1919 1.09665292890276 0.0249484173781045 0.133107010721429 Nonsignificant None -- -- -- -- -- Predicted aminopeptidases - M20/M25/M40 family E Amino acid transport and metabolism ; IPR007484 [Peptidase M28] -- -- A0A0R4J0B2 Phospholipase B-like Plbd1 1748.2 1819.5 1838.4 2150.1 2333.5 2320 0.794594038450232 0.00201730610833187 -0.331710125436369 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein Lama T Signal transduction mechanisms ; IPR007000 [Phospholipase B-like] -- -- Z4YKC4 Eukaryotic translation initiation factor 4 gamma 3 Eif4g3 475.3 483.1 546.8 510.2 511 496.2 0.991959931461711 0.869089762608827 -0.0116462483165134 Nonsignificant None 2 Molecular Function:RNA binding (GO:0003723),Molecular Function:protein binding (GO:0005515) translation initiation factor 4G -- ko03013 RNA transport ko05416 Viral myocarditis Translation initiation factor 4F, ribosome/mRNA-bridging subunit (eIF-4G) J Translation, ribosomal structure and biogenesis ; IPR003307 [W2 domain] ; IPR003890[MIF4G-like, type 3] ; IPR003891[Initiation factor eIF-4 gamma, MA3] -- -- E9PY39 Predicted gene 20431 Gm20431 672.2 686.7 728.9 843 801.7 765.6 0.866199228311828 0.0186722054958716 -0.207229207763795 Nonsignificant None -- -- transmembrane protein 189 -- -- Ubiquitin-conjugating enzyme E2 O Posttranslational modification, protein turnover, chaperones ; IPR000608 [Ubiquitin-conjugating enzyme E2] ; IPR019547[B domain of TMEM189, localisation domain] -- -- Q80SU7 Interferon-induced very large GTPase 1 Gvin1 1427.8 1368.7 1471.9 1342.5 1458.6 1325.3 1.03441256300892 0.409568273989585 0.0488117019937922 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q9ESU7 Amino acid transporter Slc1a5 957.2 958.2 944.1 1037.2 1052.3 1053 0.90994431185362 0.000162978901585825 -0.136149839104583 Nonsignificant None 2 Molecular Function:symporter activity (GO:0015293),Cellular Component:integral component of membrane (GO:0016021) solute carrier family 1 (neutral amino acid transporter), member 5 -- ko04974 Protein digestion and absorption ko05230 Central carbon metabolism in cancer Glutamate/aspartate and neutral amino acid transporters E Amino acid transport and metabolism ; IPR001991 [Sodium:dicarboxylate symporter] -- -- P15947 Kallikrein-1 Klk1 2391.2 2117.9 2830.2 3788.3 3866.8 4092.8 0.624732930991922 0.00291749969339496 -0.678688515477684 Significant down 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) tissue kallikrein 3.4.21.35 ko04614 Renin-angiotensin system ko04961 Endocrine and other factor-regulated calcium reabsorption Trypsin E Amino acid transport and metabolism ; IPR001254 [Serine proteases, trypsin domain] -- -- Q80UU9 Membrane-associated progesterone receptor component 2 Pgrmc2 2357.5 2454.4 1804.9 1834.6 1837.6 1842.1 1.19993471519504 0.210898727089762 0.262955915311706 Nonsignificant None -- -- membrane-associated progesterone receptor component -- -- Putative steroid membrane receptor Hpr6.6/25-Dx R General function prediction only ; IPR001199 [Cytochrome b5-like heme/steroid binding domain] -- -- P52760 2-iminobutanoate/2-iminopropanoate deaminase Rida 1980.4 1921.1 2780 2808.7 2246.7 3186.8 0.810645216083084 0.252042518204927 -0.302857446766956 Nonsignificant None -- -- 2-iminobutanoate/2-iminopropanoate deaminase 3.5.99.10 -- Putative translation initiation inhibitor UK114/IBM1 J Translation, ribosomal structure and biogenesis ; IPR006175 [YjgF/YER057c/UK114 family] -- -- A0A0R4J0X8 Rho guanine nucleotide exchange factor 7 Arhgef7 2104.4 2149.8 1558.1 1498.4 1509.9 1586.5 1.26497344824584 0.163839084129776 0.339107103112417 Nonsignificant None 2 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Biological Process:regulation of Rho protein signal transduction (GO:0035023) Rho guanine nucleotide exchange factor 7 -- ko04810 Regulation of actin cytoskeleton Guanine nucleotide exchange factor F Nucleotide transport and metabolism ; IPR000219 [Dbl homology (DH) domain] ; IPR001849[Pleckstrin homology domain] ; IPR011511[Variant SH3 domain] ; IPR032409[Rho guanine nucleotide exchange factor, coiled-coil domain] -- -- Q5GQ64 Gamma-synuclein (Fragment) Sncg 946.1 917.1 1173.7 1418.6 1413.5 1399.8 0.717620926770482 0.03850515115508 -0.478706133131042 Nonsignificant None -- -- -- -- -- -- -- -- IPR001058 [Synuclein] -- -- Q3UIT2 COP9 signalosome complex subunit 6 Cops6 938.5 1016 952.3 984.3 999.5 1020.9 0.967417712250807 0.279689089574644 -0.0477891428566618 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) COP9 signalosome complex subunit 6 -- -- COP9 signalosome, subunit CSN6 OT Posttranslational modification, protein turnover, chaperones ; Signal transduction mechanisms ; IPR000555 [JAB1/MPN/MOV34 metalloenzyme domain] ; IPR024969[Rpn11/EIF3F, C-terminal] -- -- P97494 Glutamate--cysteine ligase catalytic subunit Gclc 1802.4 1790.4 1870 1949.2 1853.8 1987.5 0.943407305068647 0.0800768558072971 -0.0840473227823 Nonsignificant None 2 Molecular Function:glutamate-cysteine ligase activity (GO:0004357),Biological Process:glutathione biosynthetic process (GO:0006750) glutamate--cysteine ligase catalytic subunit 6.3.2.2 ko00270 Cysteine and methionine metabolism ko00480 Glutathione metabolism ko01100 Metabolic pathways ko04216 Ferroptosis Gamma-glutamylcysteine synthetase H Coenzyme transport and metabolism ; IPR004308 [Glutamate-cysteine ligase catalytic subunit] -- -- Q9D708 Protein S100-A16 S100a16 1878.9 1903 1316.3 1586.1 1609.3 1511 1.0832483426823 0.567332848169887 0.115364029357671 Nonsignificant None -- -- -- -- -- -- -- -- IPR013787 [S100/CaBP-9k-type, calcium binding, subdomain] -- -- Q01339 Beta-2-glycoprotein 1 Apoh 2622.8 2674.4 2045.3 1568.4 1706.4 1672.2 1.48423286840509 0.0178630848633331 0.56971746105359 Nonsignificant None -- -- beta-2-glycoprotein 1 -- ko04979 Cholesterol metabolism C-type lectin TV Signal transduction mechanisms ; Defense mechanisms ; IPR000436 [Sushi/SCR/CCP domain] ; IPR015104[Beta-2-glycoprotein-1 fifth domain] -- -- Q61749 Translation initiation factor eIF-2B subunit delta Eif2b4 1106 1165.5 1184.2 1256 1224.7 1273.2 0.920562614880524 0.0225199146084943 -0.119412240661044 Nonsignificant None 1 Biological Process:cellular metabolic process (GO:0044237) translation initiation factor eIF-2B subunit delta -- ko03013 RNA transport Translation initiation factor 2B, delta subunit (eIF-2Bdelta/GCD2) J Translation, ribosomal structure and biogenesis ; IPR000649 [Initiation factor 2B-related] -- -- Q3UPG1 Hydroxymethylbilane synthase Hmbs 1444.2 1397.3 1535.3 1426.9 1469.6 1525.8 0.989711236234539 0.775081558944393 -0.0149204371910902 Nonsignificant None 2 Molecular Function:hydroxymethylbilane synthase activity (GO:0004418),Biological Process:tetrapyrrole biosynthetic process (GO:0033014) hydroxymethylbilane synthase 2.5.1.61 ko00860 Porphyrin and chlorophyll metabolism ko01100 Metabolic pathways Porphobilinogen deaminase H Coenzyme transport and metabolism ; IPR022417 [Porphobilinogen deaminase, N-terminal] ; IPR022418[Porphobilinogen deaminase, C-terminal] -- -- G3X9B1 HEAT repeat-containing protein 1 Heatr1 398.4 394.6 340.4 345 304.3 337.8 1.14821193394793 0.0965254582507985 0.19938895545969 Nonsignificant None -- -- U3 small nucleolar RNA-associated protein 10 -- ko03008 Ribosome biogenesis in eukaryotes Uncharacterized conserved protein S Function unknown ; IPR012954 [BP28, C-terminal domain] ; IPR022125[U3 small nucleolar RNA-associated protein 10] -- -- Q9CRY7 Lysophospholipase D GDPD1 Gdpd1 1568.1 1492.8 1545.2 2039.7 2059.7 1889.2 0.769144708279063 0.00138059508596544 -0.378673039904196 Nonsignificant None 2 Biological Process:lipid metabolic process (GO:0006629),Molecular Function:phosphoric diester hydrolase activity (GO:0008081) Glycerophosphoryl diester phosphodiesterase C Energy production and conversion ; IPR030395 [Glycerophosphodiester phosphodiesterase domain] -- -- Q9CQF3 Cleavage and polyadenylation specificity factor subunit 5 Nudt21 1460.9 1484 1863.1 1487.4 1556.7 1693.2 1.01492411289131 0.877702830344562 0.0213718593825473 Nonsignificant None 3 Molecular Function:mRNA binding (GO:0003729),Cellular Component:mRNA cleavage factor complex (GO:0005849),Biological Process:mRNA polyadenylation (GO:0006378) cleavage and polyadenylation specificity factor subunit 5 -- ko03015 mRNA surveillance pathway mRNA cleavage factor I subunit A RNA processing and modification ; IPR016706 [Cleavage/polyadenylation specificity factor subunit 5] -- -- Q3TJN9 Prostaglandin-endoperoxide synthase Ptgs1 1561.6 1699.1 1845.2 1950.6 1856.6 1917.8 0.891860262008734 0.0752671432324923 -0.165110410638238 Nonsignificant None -- -- prostaglandin-endoperoxide synthase 1 1.14.99.1 ko00590 Arachidonic acid metabolism ko01100 Metabolic pathways ko04611 Platelet activation ko04726 Serotonergic synapse ko04923 Regulation of lipolysis in adipocytes Peroxidase/oxygenase R General function prediction only ; IPR019791 [Haem peroxidase, animal] -- -- Q3TIX9 U4/U6.U5 tri-snRNP-associated protein 2 Usp39 868.1 873.3 863.6 861.5 860.6 940.9 0.978220052572287 0.543712048648642 -0.0317690560447436 Nonsignificant None 3 Molecular Function:zinc ion binding (GO:0008270),Biological Process:protein deubiquitination (GO:0016579),Molecular Function:thiol-dependent ubiquitinyl hydrolase activity (GO:0036459) U4/U6.U5 tri-snRNP-associated protein 2 -- ko03040 Spliceosome Spindle pole body protein - Sad1p Z Cytoskeleton ; IPR001394 [Peptidase C19, ubiquitin carboxyl-terminal hydrolase] ; IPR001607[Zinc finger, UBP-type] -- -- Q3TW96 UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 Uap1l1 887.1 886 901.5 933.8 939.7 907.9 0.961602070899547 0.03150785541903 -0.0564880918568897 Nonsignificant None 2 Biological Process:metabolic process (GO:0008152),Molecular Function:uridylyltransferase activity (GO:0070569) -- -- ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways UDP-N-acetylglucosamine pyrophosphorylase M Cell wall/membrane/envelope biogenesis ; IPR002618 [UDPGP family] -- -- Q3UHQ6 Protein dopey-2 Dop1b 288.6 264.7 287.7 294.7 279.7 286.6 0.976771196283391 0.49736427922477 -0.0339074371416998 Nonsignificant None -- -- -- -- -- Dopey and related predicted leucine zipper transcription factors K Transcription ; IPR007249 [Dopey, N-terminal] -- -- Q4FJQ4 Casp7 protein Casp7 1992.9 1910.8 1605.1 1819.7 2090.1 1755.2 0.97242718446602 0.755847203252799 -0.0403378700253246 Nonsignificant None -- -- caspase 7 3.4.22.60 ko04210 Apoptosis ko04215 Apoptosis - multiple species ko04668 TNF signaling pathway ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05133 Pertussis ko05134 Legionellosis ko05200 Pathways in cancer Caspase, apoptotic cysteine protease D Cell cycle control, cell division, chromosome partitioning ; -- -- -- E9Q0J2 Ral GTPase-activating protein subunit beta Ralgapb 701.3 692.6 761.9 786.8 751.1 777.8 0.930949604871097 0.0932292063126945 -0.103225022452792 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; -- -- -- E9PY03 Thiosulfate sulfurtransferase (rhodanese)-like domain-containing 1 Tstd1 1112.2 1060 1165.5 1655.1 1544.9 1479.2 0.713305693280903 0.0016964040452999 -0.487407606345875 Nonsignificant None -- -- -- -- -- Rhodanese-related sulfurtransferase P Inorganic ion transport and metabolism ; IPR001763 [Rhodanese-like domain] -- -- Q3TI79 Uncharacterized protein Dkc1 1632.9 1475 1519.9 1517.3 1419.6 1578.2 1.02496068747093 0.599030306123479 0.0355685759957026 Nonsignificant None 2 Molecular Function:RNA binding (GO:0003723),Biological Process:RNA processing (GO:0006396) H/ACA ribonucleoprotein complex subunit 4 5.4.99.- ko03008 Ribosome biogenesis in eukaryotes Pseudouridine synthase J Translation, ribosomal structure and biogenesis ; IPR002478 [PUA domain] ; IPR002501[Pseudouridine synthase II, N-terminal] ; IPR012960[Dyskerin-like] ; IPR032819[tRNA pseudouridylate synthase B, C-terminal] -- -- Q8C2N9 DNA mismatch repair protein Msh6 898.2 867.6 884.2 851.2 849.2 871.4 1.03040671902947 0.0829753420928304 0.0432139060563328 Nonsignificant None 3 Molecular Function:ATP binding (GO:0005524),Biological Process:mismatch repair (GO:0006298),Molecular Function:mismatched DNA binding (GO:0030983) DNA mismatch repair protein MSH6 -- ko01524 Platinum drug resistance ko03430 Mismatch repair ko05200 Pathways in cancer ko05210 Colorectal cancer Mismatch repair ATPase MSH6 (MutS family) L Replication, recombination and repair ; IPR000313 [PWWP domain] ; IPR000432[DNA mismatch repair protein MutS, C-terminal] ; IPR007695[DNA mismatch repair protein MutS-like, N-terminal] ; IPR007696[DNA mismatch repair protein MutS, core] ; IPR007860[DNA mismatch repair protein MutS, connector domain] ; IPR007861[DNA mismatch repair protein MutS, clamp] -- -- Q3TRK3 ADF-H domain-containing protein Dbn1 925.5 939.7 973.2 1100.5 1003.2 908.7 0.942238746514407 0.367540144511747 -0.0858354355042939 Nonsignificant None 2 Molecular Function:actin binding (GO:0003779),Cellular Component:intracellular (GO:0005622) -- -- -- Drebrins and related actin binding proteins Z Cytoskeleton ; IPR002108 [Actin-depolymerising factor homology domain] -- -- Q921T2 Torsin-1A-interacting protein 1 Tor1aip1 918.9 965.9 949.8 1002 1037.4 961 0.944740701239835 0.100959242009307 -0.0820096812869603 Nonsignificant None -- -- -- -- -- -- -- -- IPR008662 [Lamina-associated polypeptide 1C] -- -- Q3UM29 Conserved oligomeric Golgi complex subunit 7 Cog7 1480.6 1448.2 1604 1812.6 1878.3 1850.8 0.817943952216829 0.00276862301789659 -0.289926105790193 Nonsignificant None 2 Biological Process:intracellular protein transport (GO:0006886),Cellular Component:Golgi transport complex (GO:0017119) conserved oligomeric Golgi complex subunit 7 -- -- Uncharacterized conserved protein S Function unknown ; IPR019335 [Conserved oligomeric Golgi complex subunit 7] -- -- Q8JZN7 Mitochondrial Rho GTPase 2 Rhot2 855.5 837.3 955.6 976.5 1010.9 1043.4 0.873828692094496 0.0373484271514236 -0.194577617552414 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) mitochondrial Rho GTPase 2 3.6.5.- ko04137 Mitophagy - animal Predicted Ras related/Rac-GTP binding protein V Defense mechanisms ; IPR001806 [Small GTPase superfamily] ; IPR013566[EF hand associated, type-1] ; IPR013567[EF hand associated, type-2] -- -- Q05CL8 La-related protein 7 Larp7 1990.5 2001.5 2121.9 2034.9 2015.4 2017.4 1.00761408771034 0.750735559983432 0.0109431980142457 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:RNA binding (GO:0003723) La-related protein 7 -- -- -- -- -- IPR000504 [RNA recognition motif domain] ; IPR006630[RNA-binding protein Lupus La] ; IPR014886[La protein, RNA-binding domain] -- -- Q3U5Q7 UMP-CMP kinase 2, mitochondrial Cmpk2 1129.4 1084.2 1136.1 1283.6 1370.3 1387 0.828948996510678 0.00304660243172783 -0.270644756429007 Nonsignificant None -- -- UMP-CMP kinase 2, mitochondrial 2.7.4.14 ko00240 Pyrimidine metabolism ko01100 Metabolic pathways Thymidylate kinase/adenylate kinase F Nucleotide transport and metabolism ; -- -- -- Q9CQB5 CDGSH iron-sulfur domain-containing protein 2 Cisd2 1501.6 1478.3 1714.5 1825.2 1935 1838.5 0.838480361512494 0.0218976634166981 -0.254151100817868 Nonsignificant None 1 Cellular Component:intracellular membrane-bounded organelle (GO:0043231) -- -- -- CDGSH-type Zn-finger containing protein R General function prediction only ; IPR018967 [Iron sulphur-containing domain, CDGSH-type] ; IPR019610[Iron sulphur domain-containing, mitoNEET, N-terminal] -- -- Q9ERS2 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 Ndufa13 1100.2 1164.3 1359.8 1558.6 1513.2 1518.9 0.789487442002309 0.0153656530932854 -0.341011776876687 Nonsignificant None -- -- NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 13 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease NADH:ubiquinone oxidoreductase, B16.6 subunit/cell death-regulatory protein CD Energy production and conversion ; Cell cycle control, cell division, chromosome partitioning ; IPR009346 [GRIM-19] -- -- Q99LJ1 Tissue alpha-L-fucosidase Fuca1 1133 1153.1 1403.4 1501.2 1483.8 1442.3 0.833352155941544 0.0502181924250001 -0.263001819861577 Nonsignificant None 2 Molecular Function:alpha-L-fucosidase activity (GO:0004560),Biological Process:carbohydrate metabolic process (GO:0005975) alpha-L-fucosidase 3.2.1.51 ko00511 Other glycan degradation Alpha-L-fucosidase G Carbohydrate transport and metabolism ; IPR000933 [Glycoside hydrolase, family 29] ; IPR031919[Alpha-L-fucosidase, C-terminal] -- -- P70268 Serine/threonine-protein kinase N1 Pkn1 1987 1981.1 2087.6 1852.5 1982.1 1875.5 1.06052433407471 0.0945637095191199 0.0847777243537471 Nonsignificant None 5 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468),Biological Process:signal transduction (GO:0007165) protein kinase N 2.7.11.13 ko04151 PI3K-Akt signaling pathway ko05132 Salmonella infection Serine/threonine protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR011072[HR1 rho-binding repeat] ; IPR017892[Protein kinase, C-terminal] -- -- Q9JJ06 Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 C1galt1 1735.6 1612 1897.4 2120.8 2047.4 2030.2 0.846186112545173 0.0218600603459092 -0.240953086251261 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 2.4.1.122 ko00512 Mucin type O-glycan biosynthesis ko01100 Metabolic pathways Galactosyltransferases G Carbohydrate transport and metabolism ; IPR003378 [Fringe-like] -- -- Q8QZR3 Pyrethroid hydrolase Ces2a Ces2a 522.8 505.7 503.9 729.2 736.9 824.1 0.66911186795913 0.00123770365399664 -0.579680661512834 Nonsignificant None -- -- -- -- ko00983 Drug metabolism - other enzymes Carboxylesterase and related proteins R General function prediction only ; IPR002018 [Carboxylesterase, type B] -- -- Q9D0B6 Protein PBDC1 Pbdc1 2119.7 2207.4 1683.1 1490.4 1346 1482.4 1.3916365657127 0.0288204965075069 0.476782491859544 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR021148 [Polysaccharide biosynthesis domain] -- -- A0A4U9FFL2 IgG1 Ighg1 3101.3 3054 2477.2 1539.5 1598.4 1654.8 1.801176789701 0.00325595685436095 0.848939792075646 Significant up -- -- immunoglobulin lambda-like polypeptide 1 -- -- -- -- -- IPR003597 [Immunoglobulin C1-set] -- -- A2RTI3 Legumain Lgmn 745 742.2 834.2 694.2 717.1 698.3 1.10039817974972 0.0851835741310462 0.138025658299812 Nonsignificant None 2 Biological Process:proteolysis (GO:0006508),Molecular Function:peptidase activity (GO:0008233) legumain 3.4.22.34 ko04142 Lysosome ko04612 Antigen processing and presentation Asparaginyl peptidases O Posttranslational modification, protein turnover, chaperones ; IPR001096 [Peptidase C13, legumain] -- -- B2RY27 Taok3 protein Taok3 1736.6 1743.4 1935.4 1887.1 1940.7 1824 0.958172617573163 0.343308928347918 -0.0616425098201867 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) thousand and one amino acid protein kinase 2.7.11.1 ko04010 MAPK signaling pathway Serine/threonine protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q8BIW1 Exopolyphosphatase PRUNE1 Prune1 1294.7 1270.7 1377.6 1379.9 1408.9 1364.1 0.949457005947651 0.115783563630203 -0.0748254222750696 Nonsignificant None 2 Cellular Component:cytoplasm (GO:0005737),Molecular Function:pyrophosphatase activity (GO:0016462) exopolyphosphatase 3.6.1.11 ko00230 Purine metabolism Exopolyphosphatases and related proteins C Energy production and conversion ; IPR001667 [DDH domain] ; IPR004097[DHHA2 domain] -- -- G3X924 Plasmalemma vesicle-associated protein Plvap 1103.6 1137.3 1241.6 1249.5 1213.3 1236 0.941521574564724 0.167819642290761 -0.0869339409284542 Nonsignificant None -- -- plasmalemma vesicle-associated protein -- -- -- -- -- IPR009538 [PV-1] -- -- Q8CHT0 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial Aldh4a1 1009.3 1057 1326 1590.4 1562.4 1510.6 0.727430630012437 0.0138964648135964 -0.459118420074475 Nonsignificant None 3 Biological Process:metabolic process (GO:0008152),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) 1-pyrroline-5-carboxylate dehydrogenase 1.2.1.88 ko00250 Alanine, aspartate and glutamate metabolism ko00330 Arginine and proline metabolism ko01100 Metabolic pathways Delta-1-pyrroline-5-carboxylate dehydrogenase E Amino acid transport and metabolism ; IPR015590 [Aldehyde dehydrogenase domain] -- -- Q921S7 39S ribosomal protein L37, mitochondrial Mrpl37 2011.5 1932.9 2410.4 2283.6 2728.4 2363.9 0.861562656760531 0.166370218699482 -0.214972375267478 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:mitochondrion (GO:0005739),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L37 -- -- -- -- -- IPR010793 [Ribosomal protein L37/S30] -- -- Q922U1 U4/U6 small nuclear ribonucleoprotein Prp3 Prpf3 1853.7 1848.8 1881.2 1591.6 1571.2 1624.6 1.16633245603041 0.000138265581341994 0.221979078677085 Nonsignificant None 1 Biological Process:mRNA processing (GO:0006397) U4/U6 small nuclear ribonucleoprotein PRP3 -- ko03040 Spliceosome Putative u4/u6 small nuclear ribonucleoprotein A RNA processing and modification ; IPR002483 [PWI domain] ; IPR010541[Domain of unknown function DUF1115] ; IPR013881[Pre-mRNA-splicing factor 3] -- -- Q9CQZ1 Heat shock factor-binding protein 1 Hsbp1 1697.5 1721.5 2019.2 1759.1 1798.3 1716.2 1.03121207524272 0.632496564369809 0.0443410625193291 Nonsignificant None 1 Molecular Function:transcription corepressor activity (GO:0003714) heat shock factor-binding protein 1 -- Heat shock factor binding protein KO Transcription ; Posttranslational modification, protein turnover, chaperones ; IPR009643 [Heat shock factor binding 1] -- -- Q6ZPV1 MKIAA1266 protein (Fragment) Mta3 398.3 364.1 360.8 343.6 377.2 383.1 1.01748346770541 0.727016592570582 0.0250053534564463 Nonsignificant None 3 Molecular Function:chromatin binding (GO:0003682),Molecular Function:zinc ion binding (GO:0008270),Molecular Function:sequence-specific DNA binding (GO:0043565) metastasis-associated protein MTA -- -- Histone deacetylase complex, MTA1 component B Chromatin structure and dynamics ; IPR000679 [Zinc finger, GATA-type] ; IPR000949[ELM2 domain] ; IPR001025[Bromo adjacent homology (BAH) domain] -- zf-GATA Q6P1B9 Bin1 protein Bin1 1062.3 1077.4 1069.3 1153 1266.3 1250.4 0.874458402594218 0.0473813346643969 -0.193538337153685 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:cytoplasm (GO:0005737) amphiphysin -- ko04144 Endocytosis ko04666 Fc gamma R-mediated phagocytosis Amphiphysin U Intracellular trafficking, secretion, and vesicular transport ; IPR001452 [SH3 domain] ; IPR004148[BAR domain] -- -- Q60829 Protein phosphatase 1 regulatory subunit 1B Ppp1r1b 3889.3 3602.7 2612.4 2685.3 2789.7 2670.9 1.24042769982445 0.232714252920462 0.310837648052184 Nonsignificant None 2 Molecular Function:protein phosphatase inhibitor activity (GO:0004864),Biological Process:signal transduction (GO:0007165) protein phosphatase 1 regulatory subunit 1B -- ko04024 cAMP signaling pathway ko04728 Dopaminergic synapse ko05030 Cocaine addiction ko05031 Amphetamine addiction ko05034 Alcoholism -- -- -- IPR008466 [Protein phosphatase inhibitor 1] -- -- Q05921 2-5A-dependent ribonuclease Rnasel 1058.7 1057 1279 1325.2 1318.4 1262.7 0.869032076389422 0.089199318091483 -0.202518666301202 Nonsignificant None 6 Molecular Function:ribonuclease activity (GO:0004540),Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Biological Process:mRNA processing (GO:0006397),Biological Process:protein phosphorylation (GO:0006468) ribonuclease L -- ko04621 NOD-like receptor signaling pathway ko05160 Hepatitis C ko05164 Influenza A ko05168 Herpes simplex infection Serine/threonine protein kinase and endoribonuclease ERN1/IRE1, sensor of the unfolded protein response pathway T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR002110[Ankyrin repeat] ; IPR010513[KEN domain] ; IPR020683[Ankyrin repeat-containing domain] -- -- Q8K297 Procollagen galactosyltransferase 1 Colgalt1 2394.9 2430.9 1983.7 1777 1904.1 1929.8 1.21361991837317 0.0572473522281049 0.2793166689296 Nonsignificant None -- -- collagen beta-1,O-galactosyltransferase 2.4.1.50 ko00310 Lysine degradation ko00514 Other types of O-glycan biosynthesis Lysyl hydrolase/glycosyltransferase family 25 O Posttranslational modification, protein turnover, chaperones ; IPR002654 [Glycosyl transferase, family 25] -- -- A0A2I3BQ39 Ubiquitin carboxyl-terminal hydrolase (Fragment) Uchl3 2735.4 2569.6 2519.8 2372.3 2489 2379.4 1.08066899609154 0.06102177418887 0.111924699924016 Nonsignificant None 3 Molecular Function:thiol-dependent ubiquitin-specific protease activity (GO:0004843),Cellular Component:intracellular (GO:0005622),Biological Process:ubiquitin-dependent protein catabolic process (GO:0006511) ubiquitin carboxyl-terminal hydrolase L3 3.4.19.12 -- Ubiquitin C-terminal hydrolase UCHL1 O Posttranslational modification, protein turnover, chaperones ; IPR001578 [Peptidase C12, ubiquitin carboxyl-terminal hydrolase] -- -- Q9D0G0 28S ribosomal protein S30, mitochondrial Mrps30 874.6 858.1 1002.9 1005.4 1060 975.2 0.899690850490035 0.122552269501984 -0.152498743538715 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:mitochondrion (GO:0005739),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S30 -- -- Mitochondrial 28S ribosomal protein S30 J Translation, ribosomal structure and biogenesis ; IPR010793 [Ribosomal protein L37/S30] -- -- Q7TNV0 Protein DEK Dek 2561.1 2640.4 2836.6 2771 2688.8 2693 0.985931213816112 0.680080861769839 -0.0204410983329412 Nonsignificant None -- -- protein DEK -- -- Chromatin-associated protein Dek and related proteins, contains SAP DNA binding domain B Chromatin structure and dynamics ; IPR014876 [DEK, C-terminal] -- -- Q8R0B2 Methionine aminopeptidase (Fragment) Metap1 400.9 372.4 445.9 521.4 498.1 584.8 0.75995761391261 0.0187675750320168 -0.396009139361867 Nonsignificant None -- -- methionyl aminopeptidase 3.4.11.18 -- Putative methionine aminopeptidase O Posttranslational modification, protein turnover, chaperones ; IPR000994 [Peptidase M24] -- -- P83940 Elongin-C Eloc 2072.2 2308.4 2187.3 2428.5 2395 2184.9 0.93714685234861 0.224458813871502 -0.0936529567632253 Nonsignificant None 1 Biological Process:ubiquitin-dependent protein catabolic process (GO:0006511) transcription elongation factor B, polypeptide 1 -- ko04066 HIF-1 signaling pathway ko04120 Ubiquitin mediated proteolysis ko05200 Pathways in cancer ko05211 Renal cell carcinoma RNA polymerase II transcription elongation factor Elongin/SIII, subunit elongin C K Transcription ; IPR016073 [SKP1 component, POZ domain] -- -- Q80UU6 Opioid growth factor receptor Ogfr 943.9 990.3 1403.2 1310.3 1500.7 1422.6 0.788312547241119 0.128177345237089 -0.343160357394346 Nonsignificant None 2 Molecular Function:receptor activity (GO:0004872),Cellular Component:membrane (GO:0016020) -- -- -- -- -- -- IPR006757 [Opioid growth factor receptor (OGFr) conserved domain] -- -- Q9DC50 Peroxisomal carnitine O-octanoyltransferase Crot 643.4 621.2 640.7 572.3 633.7 611.6 1.04825044014085 0.203834608227634 0.0679834359452196 Nonsignificant None -- -- carnitine O-octanoyltransferase 2.3.1.137 ko04146 Peroxisome Carnitine O-acyltransferase CROT I Lipid transport and metabolism ; IPR000542 [Acyltransferase ChoActase/COT/CPT] -- -- A2AMH4 Choline transporter-like protein Slc44a1 1885.6 1860 1416.4 1594.4 1609.3 1845.1 1.02242116938679 0.837653204476724 0.0319896129284073 Nonsignificant None -- -- solute carrier family 44 (choline transporter-like protein), member 1 -- ko05231 Choline metabolism in cancer Choline transporter-like protein I Lipid transport and metabolism ; IPR007603 [Choline transporter-like] -- -- B1ATP7 Zinc phosphodiesterase ELAC protein 2 Elac2 1062.9 1011.9 1168.5 1146.1 1123 1121.3 0.956612789051439 0.353915882489528 -0.063993015900846 Nonsignificant None 1 Biological Process:tRNA processing (GO:0008033) ribonuclease Z 3.1.26.11 ko03013 RNA transport Predicted metal-dependent hydrolase (beta-lactamase superfamily) R General function prediction only ; IPR001279 [Metallo-beta-lactamase] ; IPR027794[tRNase Z endonuclease] -- -- Q9EST5 Acidic leucine-rich nuclear phosphoprotein 32 family member B Anp32b 1743.4 1715.8 1340.8 1363.2 1334.9 1396.7 1.17221842336622 0.210144388047008 0.229241416984491 Nonsignificant None -- -- acidic leucine-rich nuclear phosphoprotein 32 family member B -- -- Leucine-rich acidic nuclear protein DR Cell cycle control, cell division, chromosome partitioning ; General function prediction only ; -- -- -- P16015 Carbonic anhydrase 3 Ca3 1233.1 1192.4 1369.9 1812.4 1988 1457.6 0.721833396728794 0.0417554521078038 -0.470262201610092 Nonsignificant None -- -- carbonic anhydrase 4.2.1.1 ko00910 Nitrogen metabolism Carbonic anhydrase R General function prediction only ; IPR001148 [Alpha carbonic anhydrase] -- -- Q3TZI5 DNA mismatch repair protein Msh2 635 607.5 702 643.8 649.5 679.5 0.985654906731549 0.77014130658961 -0.0208454700812685 Nonsignificant None 3 Molecular Function:ATP binding (GO:0005524),Biological Process:mismatch repair (GO:0006298),Molecular Function:mismatched DNA binding (GO:0030983) DNA mismatch repair protein MSH2 -- ko01524 Platinum drug resistance ko03430 Mismatch repair ko05200 Pathways in cancer ko05210 Colorectal cancer Mismatch repair ATPase MSH2 (MutS family) L Replication, recombination and repair ; IPR000432 [DNA mismatch repair protein MutS, C-terminal] ; IPR007695[DNA mismatch repair protein MutS-like, N-terminal] ; IPR007696[DNA mismatch repair protein MutS, core] ; IPR007860[DNA mismatch repair protein MutS, connector domain] ; IPR007861[DNA mismatch repair protein MutS, clamp] -- -- Q8C0Z1 Protein FAM234A Fam234a 1084.4 1006.1 1124.8 1213 1195.1 1238.2 0.881797987000521 0.0178260028026745 -0.181479911364957 Nonsignificant None -- -- integrin alpha FG-GAP repeat containing protein 3 -- -- -- -- -- -- -- -- Q8BK72 28S ribosomal protein S27, mitochondrial Mrps27 1877.2 1778.8 1729.6 1698.6 1759.4 1745.1 1.03507524360477 0.266187742958731 0.049735646593955 Nonsignificant None -- -- small subunit ribosomal protein S27 -- -- Uncharacterized conserved protein S Function unknown ; IPR019266 [Ribosomal protein S27, mitochondrial] -- -- P35282 Ras-related protein Rab-21 Rab21 1123.2 1247.4 1083.6 1277.9 1293.5 1218.3 0.911470564952371 0.108990567095638 -0.133732028291555 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-21 -- -- GTPase Rab21, small G protein superfamily R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- Q8CCS6 Polyadenylate-binding protein 2 Pabpn1 2501.5 2566.2 2818.7 2369.5 2407.9 2435 1.09345016915313 0.0849586356813743 0.128887475206536 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) polyadenylate-binding protein 2 -- ko03015 mRNA surveillance pathway ko05164 Influenza A Splicing factor RNPS1, SR protein superfamily A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- Q60749 KH domain-containing, RNA-binding, signal transduction-associated protein 1 Khdrbs1 3962.9 3993.7 4208.7 3714.8 3784.4 3647.2 1.09141067968133 0.0173973394776027 0.1261940659644 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) KH domain-containing, RNA-binding, signal transduction-associated protein 1 -- -- RNA-binding protein Sam68 and related KH domain proteins A RNA processing and modification ; IPR004088 [K Homology domain, type 1] ; IPR032335[Sam68, tyrosine-rich domain] ; IPR032571[KHDRBS, Qua1 domain] -- -- Q6PG98 NADPH:adrenodoxin oxidoreductase, mitochondrial (Fragment) Fdxr 1700 1669.6 1639.7 2067.2 1962.2 2029.6 0.826753589701271 0.000581830871552705 -0.27447069038512 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) adrenodoxin-NADP+ reductase 1.18.1.6 -- Ferredoxin/adrenodoxin reductase F Nucleotide transport and metabolism ; IPR023753 [FAD/NAD(P)-binding domain] -- -- F8WGF2 Nitric oxide synthase, brain Nos1 1370.9 1254.6 1261.7 1504.3 1374.9 1545.5 0.878522837706511 0.0481941784623391 -0.186848304478781 Nonsignificant None 6 Molecular Function:nitric-oxide synthase activity (GO:0004517),Molecular Function:protein binding (GO:0005515),Biological Process:nitric oxide biosynthetic process (GO:0006809),Molecular Function:FMN binding (GO:0010181),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) nitric-oxide synthase, brain 1.14.13.39 ko00220 Arginine biosynthesis ko00330 Arginine and proline metabolism ko01100 Metabolic pathways ko04020 Calcium signaling pathway ko04145 Phagosome ko04371 Apelin signaling pathway ko04713 Circadian entrainment ko04730 Long-term depression ko04926 Relaxin signaling pathway ko04970 Salivary secretion ko05010 Alzheimer's disease ko05014 Amyotrophic lateral sclerosis (ALS) NADP/FAD dependent oxidoreductase C Energy production and conversion ; IPR001433 [Oxidoreductase FAD/NAD(P)-binding] ; IPR001478[PDZ domain] ; IPR003097[FAD-binding, type 1] ; IPR004030[Nitric oxide synthase, N-terminal] ; IPR008254[Flavodoxin/nitric oxide synthase] -- -- Q9JIG7 Coiled-coil domain-containing protein 22 Ccdc22 711.5 689.3 642.6 752.2 756.8 730.1 0.912598812022688 0.0408642556845192 -0.131947319133703 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; -- -- -- Q3UY05 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial Ndufs8 1669.3 1574.7 1858.2 2367 2307 2415.5 0.719684039777135 0.00174371553765049 -0.47456443040688 Nonsignificant None -- -- -- -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease NADH:ubiquinone oxidoreductase, NDUFS8/23 kDa subunit C Energy production and conversion ; IPR017896 [4Fe-4S ferredoxin-type, iron-sulphur binding domain] -- -- P00405 Cytochrome c oxidase subunit 2 Mtco2 3381.7 3165.9 4045.7 4319.9 4170.6 4275.2 0.829825234808902 0.0542114793185664 -0.269120564961357 Nonsignificant None 5 Molecular Function:cytochrome-c oxidase activity (GO:0004129),Molecular Function:copper ion binding (GO:0005507),Cellular Component:membrane (GO:0016020),Cellular Component:integral component of membrane (GO:0016021),Biological Process:electron transport chain (GO:0022900) cytochrome c oxidase subunit 2 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04260 Cardiac muscle contraction ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Cytochrome c oxidase, subunit II, and related proteins C Energy production and conversion ; IPR002429 [Cytochrome c oxidase subunit II-like C-terminal] ; IPR011759[Cytochrome C oxidase subunit II, transmembrane domain] -- -- A0A571BDS5 Maltase-glucoamylase 2, pseudogene Mgam2-ps 669.9 659.1 764.1 747.2 779.6 631.9 0.969611340158429 0.715439198665933 -0.0445215228353109 Nonsignificant None 1 Biological Process:carbohydrate metabolic process (GO:0005975) -- -- ko00052 Galactose metabolism ko00500 Starch and sucrose metabolism ko01100 Metabolic pathways ko04973 Carbohydrate digestion and absorption Maltase glucoamylase and related hydrolases, glycosyl hydrolase family 31 G Carbohydrate transport and metabolism ; IPR000322 [Glycoside hydrolase family 31] ; IPR000519[P-type trefoil domain] ; IPR031727[Galactose mutarotase, N-terminal barrel] -- -- P31428 Dipeptidase 1 Dpep1 855.7 829.6 891.9 1307.9 1153.3 1135.3 0.71658556930349 0.00415354188382576 -0.480789104232824 Nonsignificant None 2 Biological Process:proteolysis (GO:0006508),Molecular Function:dipeptidase activity (GO:0016805) membrane dipeptidase 3.4.13.19 -- Renal dipeptidase O Posttranslational modification, protein turnover, chaperones ; IPR008257 [Renal dipeptidase family] -- -- Q3TEE6 PH domain-containing protein Fermt3 1338.3 1536.1 1404.5 1137.7 1213.7 1130.3 1.22896860728954 0.0141985734724919 0.297448064053832 Nonsignificant None -- -- kindlin 3 -- ko04611 Platelet activation Mitogen inducible gene product (contains ERM and PH domains) D Cell cycle control, cell division, chromosome partitioning ; IPR001849 [Pleckstrin homology domain] ; IPR019748[FERM central domain] -- -- A2BH40 AT-rich interactive domain-containing protein 1A Arid1a 638.3 642.6 685.2 620.4 614.2 671.2 1.03164025606045 0.43974115998321 0.0449399753371189 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) AT-rich interactive domain-containing protein 1 -- ko05225 Hepatocellular carcinoma SWI-SNF chromatin-remodeling complex protein B Chromatin structure and dynamics ; IPR001606 [ARID DNA-binding domain] ; IPR033388[SWI/SNF-like complex subunit BAF250, C-terminal] -- ARID Q3UZZ6 Sulfotransferase 1 family member D1 Sult1d1 891 882.3 2459.9 1863.1 1632.8 1722.4 0.811222045493743 0.596128624956207 -0.301831235824791 Nonsignificant None 1 Molecular Function:sulfotransferase activity (GO:0008146) -- -- -- Sulfotransferase R General function prediction only ; IPR000863 [Sulfotransferase domain] -- -- Q9D1J3 SAP domain-containing ribonucleoprotein Sarnp 2473.1 2483.8 2713.2 2534.7 2685.3 2423.4 1.00349320982809 0.938873238025048 0.00503085468708834 Nonsignificant None -- -- SAP domain-containing ribonucleoprotein -- -- Putative nucleic acid-binding protein Hcc-1/proliferation associated cytokine-inducible protein, contains SAP domain D Cell cycle control, cell division, chromosome partitioning ; IPR003034 [SAP domain] -- -- Q8BH69 Selenide, water dikinase 1 Sephs1 1143.7 1116.6 968 1043.5 1020.1 1067.5 1.0310434032768 0.59579455107503 0.0441050663376339 Nonsignificant None -- -- selenide, water dikinase 2.7.9.3 ko00450 Selenocompound metabolism ko01100 Metabolic pathways Selenophosphate synthetase T Signal transduction mechanisms ; IPR010918 [AIR synthase-related protein, C-terminal domain] ; IPR016188[PurM-like, N-terminal domain] -- -- Q3TAM9 Uncharacterized protein Bag3 1936.7 1891.4 1812.3 1861.3 1897.8 1880.1 1.0002127961413 0.992073551259912 0.000306967278201223 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:chaperone binding (GO:0051087) BCL2-associated athanogene 3 -- -- BCL2-associated athanogene-like proteins and related BAG family chaperone regulators T Signal transduction mechanisms ; IPR001202 [WW domain] ; IPR003103[BAG domain] -- -- Q8VE37 Regulator of chromosome condensation Rcc1 1924.4 1808.3 1665.6 1683.6 1771.4 1690 1.04923226433431 0.350755295018377 0.0693340768781477 Nonsignificant None -- -- regulator of chromosome condensation -- -- FOG: RCC1 domain S Function unknown ; IPR000408 [Regulator of chromosome condensation, RCC1] -- -- Q9D880 Mitochondrial import inner membrane translocase subunit TIM50 Timm50 1613.9 1654.4 1785.4 1624.3 1539.9 1593.5 1.0622149357883 0.160349307145487 0.0870757203993552 Nonsignificant None -- -- mitochondrial import inner membrane translocase subunit TIM50 -- -- TFIIF-interacting CTD phosphatase, including NLI-interacting factor (involved in RNA polymerase II regulation) K Transcription ; IPR004274 [FCP1 homology domain] -- -- Q6ZWM4 U6 snRNA-associated Sm-like protein LSm8 Lsm8 1065.4 1057.9 997.4 1066.1 1082.7 1055.5 0.97391005835908 0.291169290363318 -0.0381395508659894 Nonsignificant None -- -- U6 snRNA-associated Sm-like protein LSm8 -- ko03018 RNA degradation ko03040 Spliceosome Small Nuclear ribonucleoprotein splicing factor A RNA processing and modification ; IPR001163 [LSM domain, eukaryotic/archaea-type] -- -- Q5SWD9 Pre-rRNA-processing protein TSR1 homolog Tsr1 892.5 844.6 812.7 752.6 703.6 716.6 1.1735088365243 0.010176607063119 0.230828705399037 Nonsignificant None 2 Cellular Component:nucleus (GO:0005634),Biological Process:ribosome biogenesis (GO:0042254) pre-rRNA-processing protein TSR1 -- -- Uncharacterized conserved protein S Function unknown ; IPR007034 [Ribosome biogenesis protein BMS1/TSR1, C-terminal] ; IPR012948[AARP2CN] -- -- Q9CYT6 Adenylyl cyclase-associated protein 2 Cap2 1134.2 1068.4 1074.3 1082.2 1113.6 1133.4 0.984290520245104 0.535796371166248 -0.0228438949164327 Nonsignificant None 2 Molecular Function:actin binding (GO:0003779),Biological Process:cytoskeleton organization (GO:0007010) adenylyl cyclase-associated protein -- -- Adenylate cyclase-associated protein (CAP/Srv2p) ZT Cytoskeleton ; Signal transduction mechanisms ; IPR013912 [Adenylate cyclase-associated CAP, C-terminal] ; IPR013992[Adenylate cyclase-associated CAP, N-terminal] -- -- Q62348 Translin Tsn 1884.9 1835 1856.8 1616.8 1710.3 1904.1 1.06604603150329 0.250760260698289 0.0922697345208502 Nonsignificant None 1 Molecular Function:sequence-specific DNA binding (GO:0043565) -- -- -- Translin family protein R General function prediction only ; IPR002848 [Translin family] -- -- Q3U965 Uncharacterized protein Acot8 1007.1 949.5 1099 1126.3 1159.2 1113.6 0.898943838074785 0.0660087556690781 -0.153697109361171 Nonsignificant None -- -- acyl-CoA thioesterase 8 3.1.2.27 ko00120 Primary bile acid biosynthesis ko01100 Metabolic pathways ko04146 Peroxisome Acyl-CoA thioesterase I Lipid transport and metabolism ; -- -- -- Q62148 Retinal dehydrogenase 2 Aldh1a2 132.8 132 149.5 170.8 179.2 170.1 0.796577581234378 0.00532247402536473 -0.328113217616993 Nonsignificant None 3 Biological Process:metabolic process (GO:0008152),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) retinal dehydrogenase 1.2.1.36 ko00830 Retinol metabolism ko01100 Metabolic pathways Aldehyde dehydrogenase C Energy production and conversion ; IPR015590 [Aldehyde dehydrogenase domain] -- -- Q9WTK5 Nuclear factor NF-kappa-B p100 subunit Nfkb2 1042.3 1042.2 1137.2 1183.7 1298.3 1091.2 0.901628792119109 0.158774470286981 -0.149394508409817 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Molecular Function:protein binding (GO:0005515),Biological Process:signal transduction (GO:0007165) nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 -- ko04010 MAPK signaling pathway ko04064 NF-kappa B signaling pathway ko04380 Osteoclast differentiation ko05134 Legionellosis ko05166 HTLV-I infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05224 Breast cancer -- -- -- IPR000488 [Death domain] ; IPR011539[Rel homology domain (RHD), DNA-binding domain] ; IPR020683[Ankyrin repeat-containing domain] ; IPR032397[Rel homology dimerisation domain] -- RHD Q3TW01 Ras-related protein Rab Rab32 775.8 732.1 705.6 685.3 800.2 744.7 0.992511882342391 0.893347741487883 -0.0108437205976858 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-32 -- -- GTP-binding protein-like, RAS superfamily T Signal transduction mechanisms ; IPR001806 [Small GTPase superfamily] -- -- Q9D8W7 OCIA domain-containing protein 2 Ociad2 1759.6 1778.8 2933.3 2939.7 2294.7 2571.5 0.829078005098707 0.360138031410325 -0.270420248564688 Nonsignificant None -- -- -- -- -- -- -- -- IPR009764 [Ovarian carcinoma immunoreactive antigen] -- -- A0A6I8MWZ0 Peptidylprolyl isomerase (Fragment) Fkbp15 1282 1241.6 957.2 977.9 981.3 1001.8 1.17554880108072 0.231621203589444 0.233334431475613 Nonsignificant None -- -- FK506-binding protein 15 -- -- Uncharacterized conserved protein S Function unknown ; IPR001179 [FKBP-type peptidyl-prolyl cis-trans isomerase domain] -- -- Q3TQ49 Uncharacterized protein Stam 1248 1144.7 1298.5 1428.6 1433 1383.1 0.869602092020638 0.0183882662548434 -0.201572683795175 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Biological Process:intracellular protein transport (GO:0006886) signal transducing adaptor molecule -- ko04144 Endocytosis ko04630 Jak-STAT signaling pathway Signal transducing adaptor protein STAM/STAM2 T Signal transduction mechanisms ; IPR001452 [SH3 domain] ; IPR002014[VHS domain] ; IPR003903[Ubiquitin interacting motif] -- -- Q8VCI5 Peroxisomal biogenesis factor 19 Pex19 1396.9 1411.8 1487.5 1308.1 1435.8 1352.4 1.04880013670874 0.227422853229858 0.0687397787243685 Nonsignificant None 1 Cellular Component:peroxisome (GO:0005777) peroxin-19 -- ko04146 Peroxisome 40 kDa farnesylated protein associated with peroxisomes U Intracellular trafficking, secretion, and vesicular transport ; IPR006708 [Pex19 protein] -- -- Q8K009 Mitochondrial 10-formyltetrahydrofolate dehydrogenase Aldh1l2 598.4 495.7 515.7 603.5 650.8 592.9 0.871481160675617 0.0936274007684997 -0.198458617792438 Nonsignificant None 4 Biological Process:metabolic process (GO:0008152),Biological Process:biosynthetic process (GO:0009058),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) formyltetrahydrofolate dehydrogenase 1.5.1.6 ko00670 One carbon pool by folate Formyltetrahydrofolate dehydrogenase F Nucleotide transport and metabolism ; IPR002376 [Formyl transferase, N-terminal] ; IPR005793[Formyl transferase, C-terminal] ; IPR009081[Phosphopantetheine binding ACP domain] ; IPR015590[Aldehyde dehydrogenase domain] -- -- Q3UGA8 Amidophosphoribosyltransferase Ppat 1792.9 1769.5 1568.3 1881 1931.1 1924.3 0.894411128931037 0.0505380123399495 -0.160989955505758 Nonsignificant None 1 Biological Process:nucleoside metabolic process (GO:0009116) amidophosphoribosyltransferase 2.4.2.14 ko00230 Purine metabolism ko00250 Alanine, aspartate and glutamate metabolism ko01100 Metabolic pathways Glutamine phosphoribosylpyrophosphate amidotransferase F Nucleotide transport and metabolism ; IPR000836 [Phosphoribosyltransferase domain] -- -- A0A0R4J0J6 THO complex subunit 5 homolog Thoc5 1214.2 1211 1241.1 1202.4 1232.1 1188.9 1.01183970856102 0.420229706964686 0.0169807623838933 Nonsignificant None -- -- THO complex subunit 5 -- ko03013 RNA transport Conserved coiled/coiled coil protein S Function unknown ; IPR019163 [THO complex, subunit 5] -- -- O88958 Glucosamine-6-phosphate isomerase 1 Gnpda1 1847.4 1817.6 1900.7 1743.4 1853.3 2314.1 0.94161534817622 0.579271163022991 -0.0867902586260683 Nonsignificant None 1 Biological Process:carbohydrate metabolic process (GO:0005975) glucosamine-6-phosphate deaminase 3.5.99.6 ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways Glucosamine-6-phosphate isomerase G Carbohydrate transport and metabolism ; IPR006148 [Glucosamine/galactosamine-6-phosphate isomerase] -- -- A0A338P6P6 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein Acap2 1732.5 1694.5 1845.5 1877.5 1933.9 2005.5 0.906410631092162 0.0362438267990525 -0.141763312574921 Nonsignificant None 1 Molecular Function:GTPase activator activity (GO:0005096) Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein -- ko04144 Endocytosis Putative GTPase activating proteins (GAPs) T Signal transduction mechanisms ; IPR001164 [Arf GTPase activating protein] ; IPR001849[Pleckstrin homology domain] ; IPR020683[Ankyrin repeat-containing domain] -- -- P70699 Lysosomal alpha-glucosidase Gaa 949 904 1014.7 1028.6 1070.9 1089.2 0.899332016182143 0.043825222690846 -0.153074265387772 Nonsignificant None 1 Biological Process:carbohydrate metabolic process (GO:0005975) lysosomal alpha-glucosidase 3.2.1.20 ko00052 Galactose metabolism ko00500 Starch and sucrose metabolism ko01100 Metabolic pathways ko04142 Lysosome Maltase glucoamylase and related hydrolases, glycosyl hydrolase family 31 G Carbohydrate transport and metabolism ; IPR000322 [Glycoside hydrolase family 31] ; IPR000519[P-type trefoil domain] ; IPR025887[Glycoside hydrolase family 31, N-terminal domain] ; IPR031727[Galactose mutarotase, N-terminal barrel] -- -- Q8BH40 Syntaxin-7 Stx7 918.2 902.3 870.4 964.5 959.8 885.9 0.957547505515622 0.243204805541446 -0.0625840315869135 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) syntaxin 7 -- ko04130 SNARE interactions in vesicular transport ko04145 Phagosome SNARE protein PEP12/VAM3/Syntaxin 7/Syntaxin 17 U Intracellular trafficking, secretion, and vesicular transport ; IPR000727 [Target SNARE coiled-coil homology domain] -- -- A2ARP8 Microtubule-associated protein 1A Map1a 435.5 438.9 489.3 471.4 492 478.8 0.945569269172098 0.228233885957942 -0.0807449459343659 Nonsignificant None -- -- microtubule-associated protein 1 -- -- Microtubule-associated proteins Z Cytoskeleton ; -- -- -- Q91WG2 Rab GTPase-binding effector protein 2 Rabep2 1018.8 942.4 1060.3 1077.5 1059.7 1087.1 0.937102626926775 0.129197133795829 -0.0937210413992151 Nonsignificant None 2 Molecular Function:GTPase activator activity (GO:0005096),Molecular Function:growth factor activity (GO:0008083) Rab GTPase-binding effector protein 2 -- -- Rab5 GTPase effector Rabaptin-5 U Intracellular trafficking, secretion, and vesicular transport ; IPR015390 [Rabaptin, GTPase-Rab5 binding domain] ; IPR018514[Rabaptin coiled-coil domain] -- -- P19137 Laminin subunit alpha-1 Lama1 1027.9 1059.7 879.2 821.4 822.5 806.9 1.21054349600131 0.0894313909253682 0.275654917699517 Nonsignificant None 5 Molecular Function:receptor binding (GO:0005102),Biological Process:cell adhesion (GO:0007155),Biological Process:regulation of cell adhesion (GO:0030155),Biological Process:regulation of cell migration (GO:0030334),Biological Process:regulation of embryonic development (GO:0045995) laminin, alpha 1/2 -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko05145 Toxoplasmosis ko05146 Amoebiasis ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05222 Small cell lung cancer Extracellular matrix glycoprotein Laminin subunits alpha and gamma W Extracellular structures ; IPR000034 [Laminin IV] ; IPR001791[Laminin G domain] ; IPR002049[Laminin EGF domain] ; IPR008211[Laminin, N-terminal] ; IPR009254[Laminin alpha, domain I] ; IPR010307[Laminin domain II] -- -- P50518 V-type proton ATPase subunit E 1 Atp6v1e1 2642.1 2624.6 2888.2 2750.3 2806.4 2876.5 0.966999478252621 0.373126712982247 -0.0484129835953389 Nonsignificant None 1 Biological Process:ATP hydrolysis coupled proton transport (GO:0015991) V-type H+-transporting ATPase subunit E -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04145 Phagosome ko04150 mTOR signaling pathway ko04721 Synaptic vesicle cycle ko04966 Collecting duct acid secretion ko05323 Rheumatoid arthritis Vacuolar H+-ATPase V1 sector, subunit E C Energy production and conversion ; IPR002842 [ATPase, V1/A1 complex, subunit E] -- -- D3YU12 NmrA-like family domain-containing protein 1 Nmral1 1846.8 1886.9 1911.2 1861.9 1938.3 1957.8 0.980357763112192 0.339215879612603 -0.0286197651717968 Nonsignificant None -- -- -- -- -- -- -- -- IPR008030 [NmrA-like domain] -- -- P28740 Kinesin-like protein KIF2A Kif2a 2441.6 2354.6 2318.9 2404.9 2521 2461.6 0.963126903553299 0.140574224179599 -0.0542021918707726 Nonsignificant None 4 Molecular Function:microtubule motor activity (GO:0003777),Molecular Function:ATP binding (GO:0005524),Biological Process:microtubule-based movement (GO:0007018),Molecular Function:microtubule binding (GO:0008017) kinesin family member 2/24 -- -- Kinesin-like protein Z Cytoskeleton ; IPR001752 [Kinesin motor domain] -- -- Q5U458 DnaJ homolog subfamily C member 11 Dnajc11 1816.5 1774.5 1743.6 1788.4 1855.5 1898.5 0.962507217090069 0.145385992222679 -0.055130736508288 Nonsignificant None -- -- DnaJ homolog subfamily C member 11 -- -- Molecular chaperone (DnaJ superfamily) O Posttranslational modification, protein turnover, chaperones ; IPR001623 [DnaJ domain] ; IPR024586[DnaJ-like protein C11, C-terminal] -- -- Q3UZR8 Translation initiation factor eIF-2B subunit alpha Eif2b1 2816 2738.1 2334 2177.1 2234.2 2273.1 1.18007599784573 0.0575619372305725 0.238879773302854 Nonsignificant None 1 Biological Process:cellular metabolic process (GO:0044237) translation initiation factor eIF-2B subunit alpha -- ko03013 RNA transport Translation initiation factor 2B, alpha subunit (eIF-2Balpha/GCN3) J Translation, ribosomal structure and biogenesis ; IPR000649 [Initiation factor 2B-related] -- -- E9Q317 Histone deacetylase complex subunit SAP18 Sap18 1767.5 1834.1 1563.9 1560.4 1558.3 1594.2 1.09603428886673 0.202522122132566 0.132292932973787 Nonsignificant None -- -- histone deacetylase complex subunit SAP18 -- ko03013 RNA transport ko03015 mRNA surveillance pathway Transcriptional co-repressor component K Transcription ; IPR010516 [Sin3 associated polypeptide p18] -- -- Q9JI11 Serine/threonine-protein kinase 4 Stk4 951.2 963 1043.2 967.8 966.9 952.1 1.02445614521269 0.467534238776007 0.0348582269666744 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) serine/threonine kinase 4 -- ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04068 FoxO signaling pathway ko05200 Pathways in cancer ko05223 Non-small cell lung cancer STE20-like serine/threonine kinase MST T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR024205[Mst1 SARAH domain] -- -- Q3U2Z5 SH3 domain-containing protein Eps8 1083.2 1016.7 1004.2 1083.6 1073.1 1017.1 0.978038943852795 0.508624307616874 -0.0320361828952241 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) epidermal growth factor receptor kinase substrate 8 -- -- Epidermal growth factor receptor kinase substrate T Signal transduction mechanisms ; IPR001452 [SH3 domain] ; IPR013625[Tensin/EPS8 phosphotyrosine-binding domain] -- -- Q61584 RNA-binding protein FXR1 Fxr1 2196 2266.9 2188.1 1779.8 1830.5 1850.6 1.21793111025655 0.000265933685556309 0.284432532503691 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) fragile X mental retardation protein -- ko03013 RNA transport -- -- -- IPR004088 [K Homology domain, type 1] ; IPR008395[Agenet-like domain] ; IPR022034[Fragile X-related 1 protein, C-terminal core] ; IPR032172[Fragile X-related 1 protein, C-terminal region 1] ; IPR032177[Fragile X-related 1 protein, C-terminal region 3] -- -- G5E8I8 Calcium homeostasis endoplasmic reticulum protein Cherp 1558.9 1675.5 1647.1 1448.9 1472.6 1530.8 1.09639961368282 0.0285806822864644 0.132773724941791 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:RNA binding (GO:0003723),Biological Process:RNA processing (GO:0006396) calcium homeostasis endoplasmic reticulum protein -- ko03040 Spliceosome Predicted RNA binding protein, contains SWAP, RPR and G-patch domains R General function prediction only ; IPR000061 [SWAP/Surp] ; IPR000467[G-patch domain] ; IPR006903[RNA polymerase II-binding domain] -- -- Q63886 UDP-glucuronosyltransferase 1A1 Ugt1a1 376.2 392.7 627.3 406.6 399.1 395.1 1.16272485009993 0.506205001890018 0.217509734505816 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) glucuronosyltransferase 2.4.1.17 ko00040 Pentose and glucuronate interconversions ko00053 Ascorbate and aldarate metabolism ko00140 Steroid hormone biosynthesis ko00830 Retinol metabolism ko00860 Porphyrin and chlorophyll metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko00983 Drug metabolism - other enzymes ko01100 Metabolic pathways ko05204 Chemical carcinogenesis UDP-glucuronosyl and UDP-glucosyl transferase GC Carbohydrate transport and metabolism ; Energy production and conversion ; IPR002213 [UDP-glucuronosyl/UDP-glucosyltransferase] -- -- Q3UGR5 Haloacid dehalogenase-like hydrolase domain-containing protein 2 Hdhd2 908.4 827.9 1008.1 1135.1 1167.1 1242.6 0.774204468517265 0.0119922468195058 -0.369213460353117 Nonsignificant None -- -- -- -- -- Predicted sugar phosphatase (HAD superfamily) R General function prediction only ; IPR006357 [HAD-superfamily hydrolase, subfamily IIA] -- -- A0A0N4SUH4 Pumilio homolog 3 Pum3 1220.5 1247.3 1010.8 896.1 951.1 950.3 1.24346738159071 0.0419551912597385 0.314368663538303 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) pumilio homology domain family member 6 -- -- Puf family RNA-binding protein J Translation, ribosomal structure and biogenesis ; IPR012959 [CPL domain] -- -- Q99PG0 Arylacetamide deacetylase Aadac 1045.7 1008.2 1204.8 1547.6 1492.3 1007.9 0.805054597559168 0.221309071925912 -0.312841466993218 Nonsignificant None 2 Biological Process:metabolic process (GO:0008152),Molecular Function:hydrolase activity (GO:0016787) arylacetamide deacetylase 3.1.1.3 -- Arylacetamide deacetylase V Defense mechanisms ; IPR013094 [Alpha/beta hydrolase fold-3] -- -- A0A140T8R7 REST corepressor 1 Rcor1 457.1 462.8 422 402 426.9 456.4 1.04403641173267 0.404171011764949 0.0621720281052187 Nonsignificant None -- -- REST corepressor 1 -- ko05016 Huntington's disease Predicted DNA-binding protein, contains Myb-like, SANT and ELM2 domains K Transcription ; IPR000949 [ELM2 domain] ; IPR001005[SANT/Myb domain] -- MYB P63024 Vesicle-associated membrane protein 3 Vamp3 232.4 239.2 246.2 215.3 219.5 187.2 1.1540192926045 0.0427591164117779 0.206667342798112 Nonsignificant None 2 Cellular Component:integral component of membrane (GO:0016021),Biological Process:vesicle-mediated transport (GO:0016192) vesicle-associated membrane protein 3 -- ko04130 SNARE interactions in vesicular transport ko04145 Phagosome Synaptobrevin/VAMP-like protein U Intracellular trafficking, secretion, and vesicular transport ; IPR001388 [Synaptobrevin] -- -- Q3URE1 Malonate--CoA ligase ACSF3, mitochondrial Acsf3 548.2 581 655.3 636.6 638.1 658.9 0.922889946214315 0.200811389201408 -0.115769476829197 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) malonyl-CoA/methylmalonyl-CoA synthetase 6.2.1.- ko00280 Valine, leucine and isoleucine degradation Acyl-CoA synthetase I Lipid transport and metabolism ; IPR000873 [AMP-dependent synthetase/ligase] ; IPR025110[AMP-binding enzyme C-terminal domain] -- -- P49615 Cyclin-dependent kinase 5 Cdk5 1403.9 1337.4 1390.8 1571.4 1509.9 1588.6 0.88483693440973 0.00464027046832975 -0.176516487821025 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) cyclin-dependent kinase 5 2.7.11.22 ko04360 Axon guidance ko05010 Alzheimer's disease ko05030 Cocaine addiction Cyclin-dependent kinase CDK5 UT Intracellular trafficking, secretion, and vesicular transport ; Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q78JW9 Ubiquitin domain-containing protein UBFD1 Ubfd1 1265.8 1168.3 1183.9 1152.6 1214.2 1138 1.03229856197215 0.379219206873395 0.0458602881856528 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Ubiquitin-specific protease O Posttranslational modification, protein turnover, chaperones ; IPR000626 [Ubiquitin domain] -- -- A0A0R4J049 Protein arginine N-methyltransferase 5 Prmt5 1716 1791.6 1941.4 1720.6 1748 1712.5 1.05170716643184 0.254016901348021 0.0727330617152108 Nonsignificant None 2 Biological Process:protein methylation (GO:0006479),Molecular Function:methyltransferase activity (GO:0008168) type II protein arginine methyltransferase 2.1.1.320 ko03013 RNA transport Protein kinase inhibitor D Cell cycle control, cell division, chromosome partitioning ; IPR025799 [Protein arginine N-methyltransferase] -- -- P36552 Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial Cpox 1304.2 1219.9 1294.1 1306.4 1404.1 1438.9 0.920181231021352 0.0818120428860852 -0.120010064862821 Nonsignificant None 3 Molecular Function:coproporphyrinogen oxidase activity (GO:0004109),Biological Process:porphyrin-containing compound biosynthetic process (GO:0006779),Biological Process:oxidation-reduction process (GO:0055114) coproporphyrinogen III oxidase 1.3.3.3 ko00860 Porphyrin and chlorophyll metabolism ko01100 Metabolic pathways Coproporphyrinogen III oxidase CPO/HEM13 H Coenzyme transport and metabolism ; IPR001260 [Coproporphyrinogen III oxidase, aerobic] -- -- Q9QYA2 Mitochondrial import receptor subunit TOM40 homolog Tomm40 4076 3754.3 3444.6 3126 3078.7 3448.3 1.16802030456853 0.0666617168898648 0.224065353880351 Nonsignificant None 2 Cellular Component:mitochondrial outer membrane (GO:0005741),Biological Process:transmembrane transport (GO:0055085) mitochondrial import receptor subunit TOM40 -- ko05014 Amyotrophic lateral sclerosis (ALS) Translocase of outer mitochondrial membrane complex, subunit TOM40 U Intracellular trafficking, secretion, and vesicular transport ; IPR027246 [Eukaryotic porin/Tom40] -- -- A0A068EW80 Promyelocytic leukemia Pml 729.3 711.4 589.9 616.5 637.6 629.9 1.07781316348195 0.380529183592183 0.108107111782926 Nonsignificant None 2 Cellular Component:intracellular (GO:0005622),Molecular Function:zinc ion binding (GO:0008270) probable transcription factor PML -- ko04120 Ubiquitin mediated proteolysis ko04144 Endocytosis ko05164 Influenza A ko05168 Herpes simplex infection ko05200 Pathways in cancer ko05202 Transcriptional misregulation in cancer ko05221 Acute myeloid leukemia Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR000315 [B-box-type zinc finger] ; IPR021978[Protein of unknown function DUF3583] -- -- E9PWE9 Tyrosine-protein kinase Syk 1148.4 1140.5 1162.8 1168.9 1198.4 1173.8 0.974753607636045 0.0566446871660107 -0.0368905057322633 Nonsignificant None 2 Molecular Function:protein kinase activity (GO:0004672),Biological Process:protein phosphorylation (GO:0006468) spleen tyrosine kinase 2.7.10.2 ko04064 NF-kappa B signaling pathway ko04072 Phospholipase D signaling pathway ko04151 PI3K-Akt signaling pathway ko04380 Osteoclast differentiation ko04611 Platelet activation ko04650 Natural killer cell mediated cytotoxicity ko04662 B cell receptor signaling pathway ko04664 Fc epsilon RI signaling pathway ko04666 Fc gamma R-mediated phagocytosis ko05152 Tuberculosis ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis -- -- -- IPR000980 [SH2 domain] ; IPR001245[Serine-threonine/tyrosine-protein kinase catalytic domain] -- -- Q8R2Q4 Ribosome-releasing factor 2, mitochondrial Gfm2 566 511.2 556.9 550.9 567.3 540.4 0.985228505968889 0.684454081342193 -0.0214697244347773 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) elongation factor G -- -- Elongation factor G J Translation, ribosomal structure and biogenesis ; IPR000640 [Translation elongation factor EFG, V domain] ; IPR005517[Translation elongation factor EFG/EF2, domain IV] ; IPR009022[Elongation factor G, III-V domain] -- -- Q9D6J5 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial Ndufb8 2137.1 2148.7 2568.1 2824.1 2698.6 2891.4 0.814573156962717 0.0270844714398561 -0.295883821615083 Nonsignificant None 3 Molecular Function:NADH dehydrogenase activity (GO:0003954),Cellular Component:mitochondrion (GO:0005739),Molecular Function:NADH dehydrogenase (ubiquinone) activity (GO:0008137) NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 8 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease NADH:ubiquinone oxidoreductase, NDUFB8/ASHI subunit C Energy production and conversion ; IPR008699 [NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8] -- -- E9Q6L0 CLIP-associating protein 1 Clasp1 445.3 464.4 553.6 524.5 519.4 499.7 0.947978750971754 0.477825705559332 -0.0770733735394062 Nonsignificant None -- -- CLIP-associating protein 1/2 -- -- CLIP-associating protein R General function prediction only ; IPR024395 [CLASP N-terminal domain] -- -- Q60996 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Ppp2r5c 419.7 390.5 433.8 390.6 432.6 454.4 0.973700688791484 0.646920654376211 -0.0384497323932677 Nonsignificant None 3 Cellular Component:protein phosphatase type 2A complex (GO:0000159),Biological Process:signal transduction (GO:0007165),Molecular Function:protein phosphatase regulator activity (GO:0019888) serine/threonine-protein phosphatase 2A regulatory subunit B' -- ko03015 mRNA surveillance pathway ko04071 Sphingolipid signaling pathway ko04114 Oocyte meiosis ko04151 PI3K-Akt signaling pathway ko04152 AMPK signaling pathway ko04261 Adrenergic signaling in cardiomyocytes ko04728 Dopaminergic synapse ko05165 Human papillomavirus infection Serine/threonine protein phosphatase 2A, regulatory subunit T Signal transduction mechanisms ; IPR002554 [Protein phosphatase 2A, regulatory B subunit, B56] -- -- Q3U3B9 BSD domain-containing protein Syap1 1408.1 1305.6 1238 1206.1 1270 1168 1.08441041683818 0.150263393798599 0.116910876872362 Nonsignificant None -- -- -- -- -- Synapse-associated protein U Intracellular trafficking, secretion, and vesicular transport ; IPR005607 [BSD domain] -- -- B2C3G8 Signal transducer and activator of transcription Stat5a 283.5 270.4 237.9 233.9 228 238.4 1.13065828930458 0.0930083736169694 0.177162979890298 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Biological Process:signal transduction (GO:0007165) signal transducer and activator of transcription 5A -- ko04012 ErbB signaling pathway ko04217 Necroptosis ko04630 Jak-STAT signaling pathway ko04658 Th1 and Th2 cell differentiation ko04659 Th17 cell differentiation ko04917 Prolactin signaling pathway ko04933 AGE-RAGE signaling pathway in diabetic complications ko05161 Hepatitis B ko05162 Measles ko05166 HTLV-I infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05220 Chronic myeloid leukemia ko05221 Acute myeloid leukemia ko05223 Non-small cell lung cancer STAT protein KT Transcription ; Signal transduction mechanisms ; IPR000980 [SH2 domain] ; IPR013799[STAT transcription factor, protein interaction] ; IPR013800[STAT transcription factor, all-alpha domain] ; IPR013801[STAT transcription factor, DNA-binding] -- STAT Q14AZ9 Zinc binding alcohol dehydrogenase, domain containing 2 Zadh2 1348.6 1287.2 1402.9 1625 1571 1769.5 0.813352129694895 0.010487619495426 -0.298048012231022 Nonsignificant None 1 Biological Process:oxidation-reduction process (GO:0055114) uncharacterized protein -- -- Predicted NAD-dependent oxidoreductase R General function prediction only ; IPR013149 [Alcohol dehydrogenase, C-terminal] ; IPR013154[Alcohol dehydrogenase, N-terminal] -- -- Q9CPP6 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 Ndufa5 2028.1 1936.3 2524.7 2814.6 2720.3 2867.7 0.772272867921834 0.0273594787377468 -0.372817408478979 Nonsignificant None 2 Cellular Component:mitochondrial inner membrane (GO:0005743),Biological Process:respiratory electron transport chain (GO:0022904) NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 5 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease NADH:ubiquinone oxidoreductase, NDUFA5/B13 subunit C Energy production and conversion ; IPR006806 [ETC complex I subunit] -- -- Q9DCU1 Glutathione S-transferase Gsta3 1161 1098.9 1194.4 1737.9 1727.8 1839.8 0.651079068890774 0.000169830607448814 -0.619095335874799 Significant down 1 Molecular Function:protein binding (GO:0005515) glutathione S-transferase 2.5.1.18 ko00480 Glutathione metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko01524 Platinum drug resistance ko05200 Pathways in cancer ko05204 Chemical carcinogenesis ko05225 Hepatocellular carcinoma ko05418 Fluid shear stress and atherosclerosis Glutathione S-transferase O Posttranslational modification, protein turnover, chaperones ; IPR004045 [Glutathione S-transferase, N-terminal] ; IPR004046[Glutathione S-transferase, C-terminal] -- -- Q60634 Flotillin-2 Flot2 1439.9 1565.3 1285.6 1342.9 1370.8 1369.3 1.05089395052657 0.482492778893801 0.0716170891203751 Nonsignificant None -- -- flotillin -- ko04910 Insulin signaling pathway Flotillins UZ Intracellular trafficking, secretion, and vesicular transport ; Cytoskeleton ; IPR001107 [Band 7 domain] ; IPR031905[Flotillin, C-terminal domain] -- -- Q32MD7 Regulator of G-protein signalling 10 Rgs10 1294.1 1191.6 1163.9 1237.2 1335.1 1366.8 0.926506054682542 0.157548562936654 -0.110127690645684 Nonsignificant None -- -- regulator of G-protein signaling -- -- G protein signaling regulators T Signal transduction mechanisms ; IPR016137 [RGS domain] -- -- T1ECW4 RNA-binding protein with multiple-splicing Rbpms 1478.8 1491.1 1489.2 1340.2 1305.1 1275.2 1.13738043616886 0.000723866722559736 0.185714894135582 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- RNA binding protein (contains RRM repeats) R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- F8WJG3 Transformer-2 protein homolog beta Tra2b 1192.8 1113.1 1218.5 1207.1 1169 1205 0.984166876099522 0.608462607177389 -0.0230251340900425 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) transformer-2 protein -- ko03040 Spliceosome FOG: RRM domain R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- Q9DBD0 Inhibitor of carbonic anhydrase Ica 1292.3 1291.5 1052.3 776.9 916.9 808.1 1.45333546504656 0.013914748535198 0.539367750388742 Nonsignificant None -- -- transferrin -- ko04066 HIF-1 signaling pathway ko04216 Ferroptosis ko04978 Mineral absorption -- -- -- IPR001156 [Transferrin-like domain] -- -- A0A0A6YWB0 Muscleblind-like protein 1 Mbnl1 37.3 38 25.8 22.8 22.8 27 1.39256198347107 0.0862731879648025 0.477741543907264 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) muscleblind -- -- C3H1-type Zn-finger protein K Transcription ; IPR000571 [Zinc finger, CCCH-type] -- -- Q3UJK6 NAD-dependent protein deacetylase Sirt2 1480.8 1453.8 1415.3 1436.1 1447.7 1483.8 0.995947431083433 0.816581604053842 -0.00585850010078342 Nonsignificant None 1 Molecular Function:NAD+ binding (GO:0070403) NAD-dependent deacetylase sirtuin 2 3.5.1.- -- NAD-dependent histone deacetylases and class I sirtuins (SIR2 family) BK Chromatin structure and dynamics ; Transcription ; IPR003000 [Sirtuin family] -- -- Q61249 Immunoglobulin-binding protein 1 Igbp1 553.3 518.3 443.2 399.1 408.7 423.8 1.22994478726859 0.0469686240476606 0.298593553839602 Nonsignificant None 1 Biological Process:regulation of signal transduction (GO:0009966) immunoglobulin-binding protein 1 -- ko04136 Autophagy - other ko04140 Autophagy - animal Protein phosphatase 2A-associated protein T Signal transduction mechanisms ; IPR007304 [TAP42-like protein] -- -- Q9CYL5 Golgi-associated plant pathogenesis-related protein 1 Glipr2 816.6 924.2 1011.1 833.4 817 805.6 1.12048045602606 0.219799355740134 0.164117484867773 Nonsignificant None -- -- -- -- -- Defense-related protein containing SCP domain S Function unknown ; IPR014044 [CAP domain] -- -- Q3U3C2 NPC intracellular cholesterol transporter 2 Npc2 3828.7 4046.1 3464.1 4672.8 4676.1 4941.7 0.793451639539277 0.00683220343718296 -0.333785800652388 Nonsignificant None -- -- Niemann-Pick C2 protein -- ko04142 Lysosome ko04979 Cholesterol metabolism Major epididymal secretory protein HE1 S Function unknown ; IPR003172 [MD-2-related lipid-recognition domain] -- -- Q9CQI7 U2 small nuclear ribonucleoprotein B Snrpb2 1226.6 1272.8 1548.2 1468.7 1489.1 1494.1 0.909184842426829 0.311291555810164 -0.137354462577103 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) U2 small nuclear ribonucleoprotein B'' -- ko03040 Spliceosome Spliceosomal protein snRNP-U1A/U2B A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- Q8BY71 Histone acetyltransferase type B catalytic subunit Hat1 1655.2 1630.9 1554.6 1236.6 1280.5 1275.5 1.27635395243369 0.000468324706212566 0.352028465943973 Nonsignificant None 1 Biological Process:chromatin organization (GO:0006325) histone acetyltransferase 1 2.3.1.48 ko05034 Alcoholism Histone acetyltransferase type b catalytic subunit B Chromatin structure and dynamics ; IPR019467 [Histone acetyl transferase HAT1 N-terminal] -- -- Q9CX00 IST1 homolog Ist1 1622 1536.4 1659.2 1595.2 1739.9 1690.6 0.958592832839206 0.282497697054521 -0.0610099415630643 Nonsignificant None 1 Biological Process:protein transport (GO:0015031) vacuolar protein sorting-associated protein IST1 -- ko04144 Endocytosis Spindle pole body protein Z Cytoskeleton ; IPR005061 [Vacuolar protein sorting-associated protein Ist1] -- -- Q8BPB5 EGF-containing fibulin-like extracellular matrix protein 1 Efemp1 914.3 913.1 885.5 1041.5 1113.2 1158.7 0.818766222007605 0.00481349346913206 -0.288476509315614 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) EGF-containing fibulin-like extracellular matrix protein 1 -- -- Fibrillins and related proteins containing Ca2+-binding EGF-like domains T Signal transduction mechanisms ; IPR001881 [EGF-like calcium-binding domain] ; IPR026823[Complement Clr-like EGF domain] -- -- A0A097PUG4 Anti-lox-1 15C4 light chain 716 666.2 938.6 879.6 1002.6 822.6 0.858030168589175 0.266337188166505 -0.22089972069538 Nonsignificant None -- -- immunoglobulin lambda-like polypeptide 1 -- -- -- -- -- IPR003597 [Immunoglobulin C1-set] ; IPR013106[Immunoglobulin V-set domain] -- -- Q8K2M0 39S ribosomal protein L38, mitochondrial Mrpl38 769.1 816.9 828.1 859.1 919.8 832.2 0.924552870437747 0.106249542103458 -0.113172272567366 Nonsignificant None -- -- large subunit ribosomal protein L38 -- -- Phosphatidylethanolamine binding protein R General function prediction only ; IPR008914 [Phosphatidylethanolamine-binding protein] -- -- P15105 Glutamine synthetase Glul 1578.4 1566.6 1176.2 1724.7 1603.8 1633.5 0.870858524788392 0.194128274745911 -0.199489729868356 Nonsignificant None 3 Molecular Function:glutamate-ammonia ligase activity (GO:0004356),Biological Process:glutamine biosynthetic process (GO:0006542),Biological Process:nitrogen compound metabolic process (GO:0006807) glutamine synthetase 6.3.1.2 ko00220 Arginine biosynthesis ko00250 Alanine, aspartate and glutamate metabolism ko00630 Glyoxylate and dicarboxylate metabolism ko00910 Nitrogen metabolism ko01100 Metabolic pathways ko01230 Biosynthesis of amino acids ko04217 Necroptosis ko04724 Glutamatergic synapse ko04727 GABAergic synapse Glutamine synthetase E Amino acid transport and metabolism ; IPR008146 [Glutamine synthetase, catalytic domain] ; IPR008147[Glutamine synthetase, beta-Grasp domain] -- -- Q9CPR5 39S ribosomal protein L15, mitochondrial Mrpl15 1847.2 1721 1796.3 1633.1 1742.7 1800.4 1.03637803794289 0.363369316766469 0.0515503485671649 Nonsignificant None -- -- large subunit ribosomal protein L15 -- ko03010 Ribosome Mitochondrial/chloroplast ribosomal protein L15/L10 J Translation, ribosomal structure and biogenesis ; IPR021131 [Ribosomal protein L18e/L15P] -- -- B7ZN33 Nisch protein (Fragment) Nisch 927.3 904.5 927 897.8 935.3 988.9 0.97760453579022 0.486229323860876 -0.0326771160452902 Nonsignificant None -- -- -- -- -- Nischarin, modulator of integrin alpha5 subunit action TZ Signal transduction mechanisms ; Cytoskeleton ; IPR025875 [Leucine rich repeat 4] -- -- Q3U186 Probable arginine--tRNA ligase, mitochondrial Rars2 1237.8 1265.6 1372.7 1413.3 1414.8 1375.6 0.922068653804981 0.0643224090153372 -0.117053922522797 Nonsignificant None 3 Molecular Function:arginine-tRNA ligase activity (GO:0004814),Molecular Function:ATP binding (GO:0005524),Biological Process:arginyl-tRNA aminoacylation (GO:0006420) arginyl-tRNA synthetase 6.1.1.19 ko00970 Aminoacyl-tRNA biosynthesis Arginyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR001278 [Arginine-tRNA ligase] ; IPR008909[DALR anticodon binding] -- -- P59999 Actin-related protein 2/3 complex subunit 4 Arpc4 3031.4 3096.2 3038.8 2798.5 2900.1 3043.9 1.04848727480698 0.12911756292597 0.0683093519597571 Nonsignificant None 4 Cellular Component:Arp2/3 protein complex (GO:0005885),Cellular Component:actin cytoskeleton (GO:0015629),Biological Process:actin filament polymerization (GO:0030041),Biological Process:Arp2/3 complex-mediated actin nucleation (GO:0034314) actin related protein 2/3 complex, subunit 4 -- ko04144 Endocytosis ko04666 Fc gamma R-mediated phagocytosis ko04810 Regulation of actin cytoskeleton ko05100 Bacterial invasion of epithelial cells ko05132 Salmonella infection Actin-related protein Arp2/3 complex, subunit ARPC4 Z Cytoskeleton ; IPR008384 [Actin-related protein 2/3 complex subunit 4] -- -- Q9ERE7 LRP chaperone MESD Mesd 2231.6 2372.9 2561 2364 2341.8 2336.9 1.01743649452625 0.71015099403262 0.0249387484067144 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein (involved in mesoderm differentiation in humans) R General function prediction only ; IPR019330 [Mesoderm development candidate 2] -- -- P49586 Choline-phosphate cytidylyltransferase A Pcyt1a 946.6 903 1029.5 1056.3 1034.3 1046.1 0.917875474224504 0.0846730897421874 -0.123629654652123 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:biosynthetic process (GO:0009058) choline-phosphate cytidylyltransferase 2.7.7.15 ko00440 Phosphonate and phosphinate metabolism ko00564 Glycerophospholipid metabolism ko01100 Metabolic pathways ko05231 Choline metabolism in cancer Phosphorylcholine transferase/cholinephosphate cytidylyltransferase I Lipid transport and metabolism ; IPR004821 [Cytidyltransferase-like domain] -- -- Q8BVG4 Dipeptidyl peptidase 9 Dpp9 958.9 993.8 901.7 797.4 856.5 878.3 1.12724113419161 0.0410084817050138 0.172796163150777 Nonsignificant None 2 Biological Process:proteolysis (GO:0006508),Molecular Function:serine-type peptidase activity (GO:0008236) dipeptidyl-peptidase 9 3.4.14.5 -- Dipeptidyl aminopeptidases/acylaminoacyl-peptidases O Posttranslational modification, protein turnover, chaperones ; IPR001375 [Peptidase S9, prolyl oligopeptidase, catalytic domain] ; IPR002469[Dipeptidylpeptidase IV, N-terminal domain] -- -- P63154 Crooked neck-like protein 1 Crnkl1 1299.7 1246.7 997.9 960 976.7 1038.7 1.19120118303421 0.119616838490013 0.252417091837172 Nonsignificant None 1 Biological Process:RNA processing (GO:0006396) crooked neck -- ko03040 Spliceosome Cell cycle control protein (crooked neck) D Cell cycle control, cell division, chromosome partitioning ; IPR003107 [HAT (Half-A-TPR) repeat] -- -- Q9D2X6 Prolactin-induced protein Sval1 990.5 807 689.6 1611.3 1904.8 1731.9 0.47391387195122 0.00166213187644309 -1.07730320411662 Significant down 1 Cellular Component:extracellular region (GO:0005576) -- -- -- -- -- -- IPR007990 [Prolactin-inducible protein] -- -- P62746 Rho-related GTP-binding protein RhoB Rhob 711.3 672.8 666.6 759 817.3 786.4 0.867947686968299 0.00896074810027537 -0.204320003860216 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras homolog gene family, member B -- -- Ras-related small GTPase, Rho type R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- B1AZI6 THO complex subunit 2 Thoc2 1467.3 1433.2 1446.3 1432.4 1378.9 1423.3 1.02649600906815 0.12441991250756 0.0377280183780523 Nonsignificant None -- -- THO complex subunit 2 -- ko03013 RNA transport ko03040 Spliceosome KEKE-like motif-containing transcription regulator (Rlr1)/suppressor of sin4 K Transcription ; IPR021418 [THO complex, subunitTHOC2, C-terminal] ; IPR021726[THO complex, subunitTHOC2, N-terminal] ; IPR032302[THO complex subunit 2, N-terminal domain] -- -- Q9CRS5 Uncharacterized protein (Fragment) Ewsr1 2082.6 2058.3 2156.8 2195.7 1995 2045.4 1.00987796860217 0.775083049569335 0.0141809714631659 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:zinc ion binding (GO:0008270) RNA-binding protein EWS -- ko05202 Transcriptional misregulation in cancer Conserved Zn-finger protein R General function prediction only ; IPR000504 [RNA recognition motif domain] ; IPR001876[Zinc finger, RanBP2-type] -- -- Q561M1 Low molecular weight phosphotyrosine protein phosphatase Acp1 42.1 47.1 32.7 51.1 52.8 50.2 0.791044776119403 0.0666028953265583 -0.338168735894573 Nonsignificant None -- -- -- -- ko00730 Thiamine metabolism ko00740 Riboflavin metabolism ko01100 Metabolic pathways Protein tyrosine phosphatase T Signal transduction mechanisms ; IPR023485 [Phosphotyrosine protein phosphatase I superfamily] -- -- F8VPN4 Glycogen debranching enzyme Agl 624.9 610.3 574.8 639.7 556.4 609.1 1.002658985154 0.957944560909671 0.00383101364544239 Nonsignificant None -- -- -- -- ko00500 Starch and sucrose metabolism ko01100 Metabolic pathways Alpha amylase G Carbohydrate transport and metabolism ; IPR029436 [Eukaryotic glycogen debranching enzyme, N-terminal domain] ; IPR032788[Glycogen debranching enzyme, central domain] ; IPR032790[Glycogen debranching enzyme, C-terminal] ; IPR032792[Glycogen debranching enzyme, glucanotransferase domain] -- -- G1UCX4 Synoviocyte proliferation-associated in collagen-induced arthritis 1 Saal1 310.7 295.8 232.4 240.6 256.9 264 1.10164149704531 0.360116618097607 0.139654809587242 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q9DBZ5 Eukaryotic translation initiation factor 3 subunit K Eif3k 1307 1325.3 1219.4 1166.2 1194.4 1189 1.08510818120352 0.0407785545549175 0.117838881108143 Nonsignificant None -- -- translation initiation factor 3 subunit K -- -- Uncharacterized conserved protein S Function unknown ; IPR033464 [CSN8/PSMD8/EIF3K] -- -- Q91XH6 Vesicle transport through interaction with t-SNAREs 1B homolog Vti1b 496.9 487.2 494.3 424.4 447.3 457.1 1.11258278145695 0.00786819318829651 0.153912683453681 Nonsignificant None 2 Biological Process:intracellular protein transport (GO:0006886),Cellular Component:membrane (GO:0016020) vesicle transport through interaction with t-SNAREs 1 -- ko04130 SNARE interactions in vesicular transport V-SNARE U Intracellular trafficking, secretion, and vesicular transport ; IPR007705 [Vesicle transport v-SNARE, N-terminal] -- -- Q99NF7 Protein-serine/threonine phosphatase Ppm1b 428.7 432.6 392.9 490.3 466.8 493.4 0.864667356084109 0.0125132199905101 -0.20978287084003 Nonsignificant None 4 Molecular Function:magnesium ion binding (GO:0000287),Molecular Function:catalytic activity (GO:0003824),Molecular Function:phosphoprotein phosphatase activity (GO:0004721),Molecular Function:manganese ion binding (GO:0030145) protein phosphatase 1B 3.1.3.16 ko04010 MAPK signaling pathway Protein phosphatase 1B (formerly 2C) T Signal transduction mechanisms ; IPR001932 [PPM-type phosphatase domain] ; IPR012911[Protein serine/threonine phosphatase 2C, C-terminal] -- -- Q810A7 ATP-dependent RNA helicase DDX42 Ddx42 2175.9 2234.4 2338.4 2060.9 2182.8 2099.1 1.06399381976414 0.0857656233452658 0.0894897709316599 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase DDX42 3.6.4.13 ko03040 Spliceosome ATP-dependent RNA helicase A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR011545[DEAD/DEAH box helicase domain] -- -- Q9R1Q8 Transgelin-3 Tagln3 99 98.3 117.3 116.6 101.6 116.6 0.939665471923536 0.446324586878076 -0.0897808571346571 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) transgelin -- -- Calponin Z Cytoskeleton ; IPR000557 [Calponin repeat] ; IPR001715[Calponin homology domain] -- -- Q6PD03 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Ppp2r5a 1719.8 1684.3 1637.5 1754.2 1815.2 1828.9 0.933923642628235 0.0229022842212032 -0.0986234945293011 Nonsignificant None 3 Cellular Component:protein phosphatase type 2A complex (GO:0000159),Biological Process:signal transduction (GO:0007165),Molecular Function:protein phosphatase regulator activity (GO:0019888) serine/threonine-protein phosphatase 2A regulatory subunit B' -- ko03015 mRNA surveillance pathway ko04071 Sphingolipid signaling pathway ko04114 Oocyte meiosis ko04151 PI3K-Akt signaling pathway ko04152 AMPK signaling pathway ko04261 Adrenergic signaling in cardiomyocytes ko04728 Dopaminergic synapse ko05165 Human papillomavirus infection Serine/threonine protein phosphatase 2A, regulatory subunit T Signal transduction mechanisms ; IPR002554 [Protein phosphatase 2A, regulatory B subunit, B56] -- -- P61082 NEDD8-conjugating enzyme Ubc12 Ube2m 2016 2278.1 2338.2 2297.2 2337.9 2213.3 0.968445184276619 0.53223692334452 -0.0462577028583621 Nonsignificant None -- -- ubiquitin-conjugating enzyme E2 M -- ko04120 Ubiquitin mediated proteolysis Ubiquitin-protein ligase O Posttranslational modification, protein turnover, chaperones ; IPR000608 [Ubiquitin-conjugating enzyme E2] -- -- Q9CXX7 Uncharacterized protein Snrpa 2073.3 2198.7 2443.4 2411.6 2416.5 2004.5 0.982846939671575 0.833817935343493 -0.0249613340388629 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) U1 small nuclear ribonucleoprotein A -- ko03040 Spliceosome Spliceosomal protein snRNP-U1A/U2B A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- Q80WJ7 Protein LYRIC Mtdh 1928.1 1993.1 2176.3 1799.4 1849.6 1728.8 1.1338279593886 0.0432382901007178 0.181201750539101 Nonsignificant None 3 Biological Process:negative regulation of apoptotic process (GO:0043066),Biological Process:positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123),Biological Process:positive regulation of angiogenesis (GO:0045766) -- -- -- -- -- -- IPR031402 [Protein LYRIC] -- -- Q3UQN2 F-BAR domain only protein 2 Fcho2 794.2 929.7 975.4 1049 1059.7 1012.3 0.86488305030439 0.0668988831594469 -0.209423030522672 Nonsignificant None -- -- F-BAR domain only protein -- -- Predicted proline-serine-threonine phosphatase-interacting protein (PSTPIP) D Cell cycle control, cell division, chromosome partitioning ; IPR001060 [FCH domain] ; IPR018808[Muniscin C-terminal] -- -- P70677 Caspase-3 Casp3 1693.5 1672.5 1776.3 2003.5 1892.5 1840.4 0.896433303116937 0.0263321187239183 -0.157731847925307 Nonsignificant None -- -- caspase 3 3.4.22.56 ko01524 Platinum drug resistance ko04010 MAPK signaling pathway ko04115 p53 signaling pathway ko04210 Apoptosis ko04215 Apoptosis - multiple species ko04650 Natural killer cell mediated cytotoxicity ko04657 IL-17 signaling pathway ko04668 TNF signaling pathway ko04726 Serotonergic synapse ko04932 Non-alcoholic fatty liver disease (NAFLD) ko04933 AGE-RAGE signaling pathway in diabetic complications ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05014 Amyotrophic lateral sclerosis (ALS) ko05016 Huntington's disease ko05133 Pertussis ko05134 Legionellosis ko05145 Toxoplasmosis ko05146 Amoebiasis ko05152 Tuberculosis ko05161 Hepatitis B ko05165 Human papillomavirus infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05205 Proteoglycans in cancer ko05206 MicroRNAs in cancer ko05210 Colorectal cancer ko05222 Small cell lung cancer ko05416 Viral myocarditis Caspase, apoptotic cysteine protease D Cell cycle control, cell division, chromosome partitioning ; -- -- -- Q811E7 Myosin IF Myo1f 234.2 243.8 189 281.5 246.2 193.5 0.924847476428175 0.587200391002723 -0.112712635360394 Nonsignificant None 4 Molecular Function:motor activity (GO:0003774),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Cellular Component:myosin complex (GO:0016459) myosin I -- -- Myosin class I heavy chain Z Cytoskeleton ; IPR001452 [SH3 domain] ; IPR001609[Myosin head, motor domain] ; IPR010926[Class I myosin tail homology domain] -- -- Q5SUA5 Unconventional myosin-Ig Myo1g 720.3 732.4 744.9 574.4 715.8 672.9 1.11945392491468 0.139413392988451 0.162795150195836 Nonsignificant None 3 Molecular Function:motor activity (GO:0003774),Molecular Function:ATP binding (GO:0005524),Cellular Component:myosin complex (GO:0016459) myosin I -- -- Myosin class I heavy chain Z Cytoskeleton ; IPR001609 [Myosin head, motor domain] ; IPR010926[Class I myosin tail homology domain] -- -- P70349 Adenosine 5-monophosphoramidase HINT1 Hint1 2369.4 2399.3 2313.4 2639.3 2653.7 2817.9 0.873158342477407 0.00539657449103238 -0.195684792473079 Nonsignificant None -- -- histidine triad (HIT) family protein -- -- Zinc-binding protein of the histidine triad (HIT) family T Signal transduction mechanisms ; IPR001310 [Histidine triad (HIT) protein] -- -- Q8C547 HEAT repeat-containing protein 5B Heatr5b 762.5 680.2 667.4 630.5 699.4 681.7 1.04896599721615 0.416384160082409 0.0689679129554898 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; -- -- -- F8WGM5 Syntaxin-binding protein 2 (Fragment) Stxbp2 645.3 674.3 692.1 693.4 692.6 620.6 1.00254161267816 0.954042637291957 0.00366212013004649 Nonsignificant None 2 Biological Process:vesicle docking involved in exocytosis (GO:0006904),Biological Process:vesicle-mediated transport (GO:0016192) syntaxin-binding protein 2 -- -- Vesicle trafficking protein Sec1 U Intracellular trafficking, secretion, and vesicular transport ; IPR001619 [Sec1-like protein] -- -- Q8BU20 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial Ndufb5 2671.4 2487.7 2816 2981.7 2843 2869.3 0.917310789049919 0.0827268328192308 -0.12451748663196 Nonsignificant None -- -- NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 5 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit C Energy production and conversion ; IPR019173 [NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit] -- -- Q8BYZ7 Engulfment and cell motility protein 3 Elmo3 618.1 601 621.5 661.5 675.1 709.1 0.899740919978491 0.0116234312800818 -0.152418457079511 Nonsignificant None -- -- engulfment and cell motility protein 3 -- ko05100 Bacterial invasion of epithelial cells Regulator of Rac1, required for phagocytosis and cell migration T Signal transduction mechanisms ; IPR001849 [Pleckstrin homology domain] ; IPR006816[ELMO domain] ; IPR024574[Domain of unknown function DUF3361] -- -- Q9CVF5 Flavodoxin_2 domain-containing protein (Fragment) Nqo2 1120.7 1002.9 1164.1 1265.1 1276.1 1372.9 0.839963209933318 0.0241575463376637 -0.25160195510205 Nonsignificant None -- -- ribosyldihydronicotinamide dehydrogenase (quinone) 1.10.5.1 -- -- -- -- IPR003680 [Flavodoxin-like fold] -- -- Q8CI32 BAG family molecular chaperone regulator 5 Bag5 756.5 798 802.6 852 824.3 844.2 0.935171592937909 0.0317309604720206 -0.0966969881038178 Nonsignificant None 1 Molecular Function:chaperone binding (GO:0051087) BCL2-associated athanogene 5 -- -- BCL2-associated athanogene-like proteins and related BAG family chaperone regulators T Signal transduction mechanisms ; IPR003103 [BAG domain] -- -- Q8VCX5 Calcium uptake protein 1, mitochondrial Micu1 997.9 946.5 1140 1258 1277.5 1207.6 0.824022868745158 0.0233731689371687 -0.279243718440748 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) -- -- -- Ca2+ binding protein, contains EF-hand motifs P Inorganic ion transport and metabolism ; IPR002048 [EF-hand domain] -- -- Q0VGB7 Serine/threonine-protein phosphatase 4 regulatory subunit 2 Ppp4r2 1616.3 1651.9 1748.8 1683.2 1673.7 1713.1 0.989546351084813 0.691068263981279 -0.0151608091264061 Nonsignificant None 2 Molecular Function:protein phosphatase regulator activity (GO:0019888),Cellular Component:protein phosphatase 4 complex (GO:0030289) serine/threonine-protein phosphatase 4 regulatory subunit 2 -- -- Protein phosphatase 4 regulatory subunit 2 related protein R General function prediction only ; IPR015267 [Protein phosphatase 4 core regulatory subunit R2] -- -- Q543P7 Uncharacterized protein Arl3 720.9 699.9 667.7 816.6 863.3 774.2 0.851024815614686 0.015361052799551 -0.232726893831283 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) ADP-ribosylation factor-like protein 3 -- -- GTP-binding ADP-ribosylation factor-like protein ARL3 R General function prediction only ; IPR006689 [Small GTPase superfamily, ARF/SAR type] -- -- F6V6T4 Transmembrane emp24 domain-containing protein 2 (Fragment) Tmed2 3356.2 3310.2 3313.8 3547.5 3485.2 3583.5 0.940091558184661 0.0027841960993423 -0.0891268230902592 Nonsignificant None 2 Biological Process:transport (GO:0006810),Cellular Component:integral component of membrane (GO:0016021) p24 family protein beta-1 -- -- Putative cargo transport protein EMP24 (p24 protein family) U Intracellular trafficking, secretion, and vesicular transport ; IPR009038 [GOLD domain] -- -- Q542V3 Serine/arginine-rich-splicing factor 4 Srsf4 917.4 891.8 959.4 961.1 1000.4 1010.9 0.931435876732607 0.0522976739662576 -0.102471642418427 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) splicing factor, arginine/serine-rich 4/5/6 -- ko03040 Spliceosome ko05168 Herpes simplex infection Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- D3YZN4 Paraplegin Spg7 1059.3 1017.6 1021.5 1156 1138.2 1130.4 0.904747999766396 0.00207331757767572 -0.14441208182289 Nonsignificant None 5 Molecular Function:metalloendopeptidase activity (GO:0004222),Molecular Function:ATP binding (GO:0005524),Biological Process:proteolysis (GO:0006508),Molecular Function:zinc ion binding (GO:0008270),Cellular Component:integral component of membrane (GO:0016021) spastic paraplegia 7 3.4.24.- -- AAA+-type ATPase containing the peptidase M41 domain O Posttranslational modification, protein turnover, chaperones ; IPR000642 [Peptidase M41] ; IPR003959[ATPase, AAA-type, core] ; IPR011546[Peptidase M41, FtsH extracellular] -- -- A0A0R4J0I6 Acyl-CoA dehydrogenase family member 11 Acad11 1571.7 1519.3 1905.4 1876.3 2030.1 1838 0.869786226585892 0.137193521510257 -0.201267231559697 Nonsignificant None 4 Molecular Function:acyl-CoA dehydrogenase activity (GO:0003995),Biological Process:metabolic process (GO:0008152),Molecular Function:flavin adenine dinucleotide binding (GO:0050660),Biological Process:oxidation-reduction process (GO:0055114) acyl-CoA dehydrogenase family member 11 -- -- Predicted acyl-CoA dehydrogenase R General function prediction only ; IPR002575 [Aminoglycoside phosphotransferase] ; IPR006091[Acyl-CoA oxidase/dehydrogenase, central domain] ; IPR009075[Acyl-CoA dehydrogenase/oxidase C-terminal] ; IPR013786[Acyl-CoA dehydrogenase/oxidase, N-terminal] -- -- Q61335 B-cell receptor-associated protein 31 Bcap31 2211.2 2565.4 3429.8 3528.6 3510.4 3017.3 0.816045662917773 0.196937531409337 -0.293278212516752 Nonsignificant None 3 Cellular Component:endoplasmic reticulum (GO:0005783),Biological Process:intracellular protein transport (GO:0006886),Cellular Component:integral component of membrane (GO:0016021) B-cell receptor-associated protein 31 -- ko04141 Protein processing in endoplasmic reticulum ko05165 Human papillomavirus infection B-cell receptor-associated protein and related proteins V Defense mechanisms ; IPR008417 [B-cell receptor-associated protein 29/31] -- -- Q3TDX2 Vesicle-fusing ATPase Vps4a 688.9 695.1 646.5 726.4 679.9 685.6 0.970648692576127 0.38814970926589 -0.0429788601962665 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) vacuolar protein-sorting-associated protein 4 -- ko04144 Endocytosis ko04217 Necroptosis AAA+-type ATPase O Posttranslational modification, protein turnover, chaperones ; IPR003959 [ATPase, AAA-type, core] ; IPR007330[MIT] ; IPR015415[Vps4 oligomerisation, C-terminal] -- -- P54763 Ephrin type-B receptor 2 Ephb2 826.7 909.1 995.7 1100.9 1058.6 1004.5 0.863305941845765 0.0623024944980052 -0.212056176774797 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein binding (GO:0005515),Biological Process:protein phosphorylation (GO:0006468) Eph receptor B2 2.7.10.1 ko04360 Axon guidance Tyrosine kinase, EPH (ephrin) receptor family T Signal transduction mechanisms ; IPR001090 [Ephrin receptor ligand binding domain] ; IPR001245[Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR001660[Sterile alpha motif domain] ; IPR003961[Fibronectin type III] ; IPR011641[Tyrosine-protein kinase ephrin type A/B receptor-like] ; IPR027936[Ephrin receptor, transmembrane domain] -- -- Q9ET30 Transmembrane 9 superfamily member 3 Tm9sf3 2668.3 2562.5 3148.7 3247.5 3311.7 3209.4 0.857799479966423 0.0644816395168648 -0.221287653535122 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) transmembrane 9 superfamily member 3 -- -- Endosomal membrane proteins, EMP70 U Intracellular trafficking, secretion, and vesicular transport ; IPR004240 [Nonaspanin (TM9SF)] -- -- Q62426 Cystatin-B Cstb 4129.6 4248.7 3131.4 3134.7 3040.3 3586.7 1.17906717067724 0.21169066324955 0.237645910041624 Nonsignificant None 1 Molecular Function:cysteine-type endopeptidase inhibitor activity (GO:0004869) cystatin-A/B -- -- -- -- -- IPR000010 [Cystatin domain] -- -- Q9CPN9 RIKEN cDNA 2210010C04 gene 2210010C04Rik 706.6 597.6 658.3 685.7 1202.8 677.2 0.764898468254278 0.318546431084921 -0.386659836059023 Nonsignificant None 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) trypsin 3.4.21.4 ko04080 Neuroactive ligand-receptor interaction ko04972 Pancreatic secretion ko04974 Protein digestion and absorption ko05164 Influenza A Trypsin E Amino acid transport and metabolism ; IPR001254 [Serine proteases, trypsin domain] -- -- Q2M2Q8 Msi2h protein Msi2 1168.3 1204.4 1379.3 1641.4 1690.6 1600.5 0.760669031931069 0.00496668285104523 -0.394659223095544 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) RNA-binding protein Musashi -- ko03015 mRNA surveillance pathway RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- Q62273 Sulfate transporter Slc26a2 690.8 615.7 735 1088.3 1038 963 0.660829314084097 0.00227247543926724 -0.597650409422786 Significant down 3 Biological Process:sulfate transport (GO:0008272),Molecular Function:sulfate transmembrane transporter activity (GO:0015116),Cellular Component:integral component of membrane (GO:0016021) solute carrier family 26 (sulfate anion transporter), member 2 -- -- Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) P Inorganic ion transport and metabolism ; IPR002645 [STAS domain] ; IPR011547[SLC26A/SulP transporter domain] -- -- P26883 Peptidyl-prolyl cis-trans isomerase FKBP1A Fkbp1a 1034 1008.3 1066.3 1076.1 1081.4 1169.9 0.93424295245537 0.103739573596901 -0.0981303193383796 Nonsignificant None -- -- FK506-binding protein 1 5.2.1.8 -- FKBP-type peptidyl-prolyl cis-trans isomerase O Posttranslational modification, protein turnover, chaperones ; IPR001179 [FKBP-type peptidyl-prolyl cis-trans isomerase domain] -- -- Q3UK27 NEDD8-activating enzyme E1 regulatory subunit Nae1 1178.5 1279.3 1410.3 1461.1 1470.4 1410.2 0.890918303890181 0.0860950192798044 -0.166634950431138 Nonsignificant None 1 Molecular Function:small protein activating enzyme activity (GO:0008641) amyloid beta precursor protein binding protein 1 -- ko05010 Alzheimer's disease NEDD8-activating complex, APP-BP1/UBA5 component O Posttranslational modification, protein turnover, chaperones ; IPR000594 [THIF-type NAD/FAD binding fold] -- -- Q5M9N6 Rpl37a protein Rpl37a 4471.3 4315.1 3427 2731.5 2817.8 2900.9 1.44533857186812 0.0581467715656579 0.531407484933588 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L37Ae -- ko03010 Ribosome 60S ribosomal protein L37 J Translation, ribosomal structure and biogenesis ; IPR002674 [Ribosomal protein L37ae] -- -- Q8R1U1 Conserved oligomeric Golgi complex subunit 4 Cog4 834.8 826.2 963.6 990.4 953.5 987.1 0.895462299556465 0.0904527563275109 -0.159295401244378 Nonsignificant None -- -- conserved oligomeric Golgi complex subunit 4 -- -- Golgi transport complex COD1 protein U Intracellular trafficking, secretion, and vesicular transport ; IPR013167 [Conserved oligomeric Golgi complex, subunit 4] -- -- P07309 Transthyretin Ttr 5985.6 5798.8 5251.1 3694.8 3822.5 3775.8 1.50848748350763 0.00102127687875393 0.593102725946738 Significant up -- -- transthyretin -- ko04918 Thyroid hormone synthesis Transthyretin and related proteins I Lipid transport and metabolism ; IPR023416 [Transthyretin/hydroxyisourate hydrolase, superfamily] -- -- Q8K3H0 DCC-interacting protein 13-alpha Appl1 1286 1299.6 1500.7 1263.7 1284.7 1361.5 1.04511624338218 0.479637983132498 0.0636634154393787 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) DCC-interacting protein 13 alpha -- ko04211 Longevity regulating pathway ko05200 Pathways in cancer ko05210 Colorectal cancer Putative GTPase activating proteins (GAPs) T Signal transduction mechanisms ; IPR001849 [Pleckstrin homology domain] ; IPR006020[PTB/PI domain] -- -- Q53X15 Protein S100 S100a8 1245.2 2354.1 1247.9 438.6 423.6 435.7 3.73464827798752 0.0851020800501463 1.90097237915997 Nonsignificant None -- -- protein S100-A8 -- ko04657 IL-17 signaling pathway -- -- -- IPR013787 [S100/CaBP-9k-type, calcium binding, subdomain] -- -- Q497N1 40S ribosomal protein S26 Rps26 4802.4 3867.9 2892.3 2788.7 2728 3207.8 1.32530230958794 0.173312266613951 0.406321484805186 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S26e -- ko03010 Ribosome 40s ribosomal protein S26 J Translation, ribosomal structure and biogenesis ; IPR000892 [Ribosomal protein S26e] -- -- A0A286YCX6 Trafficking protein particle complex 8 Trappc8 1323.7 1308.1 1297.1 1293.6 1323.5 1376.9 0.983700550826239 0.443655072245683 -0.0237088845933483 Nonsignificant None -- -- trafficking protein particle complex subunit 8 -- -- Protein with predicted involvement in meiosis (GSG1) D Cell cycle control, cell division, chromosome partitioning ; IPR024420 [TRAPP III complex, Trs85] -- -- F8VQC9 Anion exchange protein Slc4a7 992.1 993.8 941 974.7 894.6 905.1 1.05496683967705 0.171186858941254 0.0771976520269239 Nonsignificant None 3 Biological Process:anion transport (GO:0006820),Molecular Function:anion transmembrane transporter activity (GO:0008509),Cellular Component:integral component of membrane (GO:0016021) solute carrier family 4 (sodium bicarbonate cotransporter), member 7 -- -- Na+-independent Cl/HCO3 exchanger AE1 and related transporters (SLC4 family) P Inorganic ion transport and metabolism ; IPR011531 [Bicarbonate transporter, C-terminal] ; IPR013769[Band 3 cytoplasmic domain] -- -- Q8VCT0 Low density lipoprotein receptor Ldlr 574.2 534.6 498.7 535.5 539.7 542.4 0.993756181998022 0.891704982201473 -0.00903616480034267 Nonsignificant None 2 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:protein binding (GO:0005515) low-density lipoprotein receptor -- ko04144 Endocytosis ko04913 Ovarian steroidogenesis ko04925 Aldosterone synthesis and secretion ko04976 Bile secretion ko04979 Cholesterol metabolism ko05145 Toxoplasmosis ko05160 Hepatitis C Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains T Signal transduction mechanisms ; IPR000033 [LDLR class B repeat] ; IPR001881[EGF-like calcium-binding domain] ; IPR002172[Low-density lipoprotein (LDL) receptor class A repeat] -- -- P58044 Isopentenyl-diphosphate Delta-isomerase 1 Idi1 1055.1 1040.2 1322.4 1811.4 2026.8 1449.9 0.646300183430722 0.0312872175739546 -0.629723693810648 Significant down 1 Molecular Function:hydrolase activity (GO:0016787) isopentenyl-diphosphate Delta-isomerase 5.3.3.2 ko00900 Terpenoid backbone biosynthesis ko01100 Metabolic pathways Isopentenyl pyrophosphate:dimethylallyl pyrophosphate isomerase Q Secondary metabolites biosynthesis, transport and catabolism ; IPR000086 [NUDIX hydrolase domain] -- -- Q80YW5 B box and SPRY domain-containing protein Bspry 1702 1548.9 1554.8 1820.6 1695 1768.5 0.90946424178195 0.0616534585056103 -0.136911179625234 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Cellular Component:intracellular (GO:0005622),Molecular Function:zinc ion binding (GO:0008270) -- -- -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR000315 [B-box-type zinc finger] ; IPR003877[SPRY domain] ; IPR006574[SPRY-associated] -- -- P51863 V-type proton ATPase subunit d 1 Atp6v0d1 1820 1852.8 1912.8 2061.1 2104.8 2163.6 0.882470969270874 0.00352339180301838 -0.18037927619515 Nonsignificant None -- -- V-type H+-transporting ATPase subunit d -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04142 Lysosome ko04145 Phagosome ko04721 Synaptic vesicle cycle ko04966 Collecting duct acid secretion ko05152 Tuberculosis ko05203 Viral carcinogenesis ko05323 Rheumatoid arthritis Vacuolar H+-ATPase V0 sector, subunit d C Energy production and conversion ; IPR002843 [ATPase, V0 complex, c/d subunit] -- -- Q3TDM2 Protein kinase domain-containing protein Camk1d 553.4 516.7 556.7 593.3 577.4 674.7 0.881543296846212 0.0901032115600421 -0.181896665884919 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) calcium/calmodulin-dependent protein kinase I 2.7.11.17 ko04921 Oxytocin signaling pathway ko04925 Aldosterone synthesis and secretion Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- P61961 Ubiquitin-fold modifier 1 Ufm1 1403.9 1396 1297.7 1403.3 1434.1 1369.2 0.974088337374602 0.403871452664872 -0.0378754826276692 Nonsignificant None -- -- ubiquitin-fold modifier 1 -- -- Uncharacterized conserved protein S Function unknown ; IPR005375 [Ubiquitin-fold modifier 1] -- -- Q8C129 Leucyl-cystinyl aminopeptidase Lnpep 1743.8 1844.8 1844.4 1780.5 1853.5 1826 0.995054945054945 0.832081886576901 -0.00715190413589068 Nonsignificant None 2 Molecular Function:metallopeptidase activity (GO:0008237),Molecular Function:zinc ion binding (GO:0008270) cystinyl aminopeptidase 3.4.11.3 ko04614 Renin-angiotensin system Puromycin-sensitive aminopeptidase and related aminopeptidases EO Amino acid transport and metabolism ; Posttranslational modification, protein turnover, chaperones ; IPR014782 [Peptidase M1, membrane alanine aminopeptidase, N-terminal] ; IPR024571[ERAP1-like C-terminal domain] -- -- E9Q481 Serine/threonine-protein phosphatase 4 regulatory subunit 3A Ppp4r3a 1357 1329.7 1715.3 1570.4 1546.2 1527.2 0.947930574098798 0.583611011244478 -0.0771466940667068 Nonsignificant None -- -- protein phosphatase 4 regulatory subunit 3 -- ko04922 Glucagon signaling pathway Protein predicted to be involved in carbohydrate metabolism G Carbohydrate transport and metabolism ; IPR006887 [Domain of unknown function DUF625] -- -- Q8VHC3 Selenoprotein M Selenom 696 718.5 816 908.3 828.9 924.3 0.83806124365959 0.038221641629722 -0.254872418151911 Nonsignificant None -- -- -- -- -- -- -- -- IPR014912 [Sep15/SelM redox] -- -- Q8R4U7 Leucine zipper protein 1 Luzp1 1210.5 1212 1297.9 1383.2 1422.7 1399.8 0.884608983046817 0.00648961431161748 -0.17688820226498 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q60739 BAG family molecular chaperone regulator 1 Bag1 1483 1600 1729.6 1634.3 1690.8 1588.6 0.979424873313389 0.684635792544947 -0.0299932599288869 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:chaperone binding (GO:0051087) BCL2-associated athanogene 1 -- ko04141 Protein processing in endoplasmic reticulum -- -- -- IPR000626 [Ubiquitin domain] ; IPR003103[BAG domain] -- -- Q8C181 Muscleblind-like protein 2 Mbnl2 379.9 412 472.3 510.4 534.9 445.9 0.847773605150215 0.116740152148997 -0.238249045115818 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) muscleblind -- -- C3H1-type Zn-finger protein K Transcription ; IPR000571 [Zinc finger, CCCH-type] -- -- P29391 Ferritin light chain 1 Ftl1 805 834.9 635.8 818.8 805.4 961.9 0.879973705579831 0.263967311774053 -0.184467679542359 Nonsignificant None 2 Biological Process:cellular iron ion homeostasis (GO:0006879),Molecular Function:ferric iron binding (GO:0008199) ferritin light chain -- ko04216 Ferroptosis ko04217 Necroptosis ko04978 Mineral absorption Ferritin P Inorganic ion transport and metabolism ; IPR008331 [Ferritin/DPS protein domain] -- -- Q9Z1P6 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 Ndufa7 2370.5 2479.8 2651.1 3160.2 2993.7 3153.9 0.805926212423989 0.00358024498648793 -0.31128033782526 Nonsignificant None 3 Cellular Component:mitochondrial inner membrane (GO:0005743),Molecular Function:NADH dehydrogenase (ubiquinone) activity (GO:0008137),Biological Process:ATP synthesis coupled electron transport (GO:0042773) NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 7 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease NADH:ubiquinone oxidoreductase, NDUFA7/B14.5A subunit C Energy production and conversion ; IPR009947 [NADH:ubiquinone oxidoreductase subunit B14.5a] -- -- O88325 Alpha-N-acetylglucosaminidase Naglu 1272.1 1308.2 1006.4 1130.8 1074.6 1115.2 1.08013611997832 0.410543926944117 0.111213133910201 Nonsignificant None -- -- alpha-N-acetylglucosaminidase 3.2.1.50 ko00531 Glycosaminoglycan degradation ko01100 Metabolic pathways ko04142 Lysosome Alpha-N-acetylglucosaminidase U Intracellular trafficking, secretion, and vesicular transport ; IPR024240 [Alpha-N-acetylglucosaminidase, N-terminal] ; IPR024732[Alpha-N-acetylglucosaminidase, C-terminal] ; IPR024733[Alpha-N-acetylglucosaminidase, tim-barrel domain] -- -- Q64464 Cytochrome P450 3A13 Cyp3a13 1158.1 1123.4 1514.7 1485.8 1408.5 1395.5 0.884936360669495 0.268619687478449 -0.176354385960356 Nonsignificant None 3 Molecular Function:iron ion binding (GO:0005506),Molecular Function:heme binding (GO:0020037),Biological Process:oxidation-reduction process (GO:0055114) cytochrome P450 family 3 subfamily A 1.14.14.1 ko00140 Steroid hormone biosynthesis ko00591 Linoleic acid metabolism ko00830 Retinol metabolism ko01100 Metabolic pathways ko05204 Chemical carcinogenesis Cytochrome P450 CYP3/CYP5/CYP6/CYP9 subfamilies Q Secondary metabolites biosynthesis, transport and catabolism ; IPR001128 [Cytochrome P450] -- -- P35175 Stefin-1 Stfa1 716.3 831.6 827.6 303.7 334.3 333.8 2.44443301090759 0.000279876598668017 1.28949986918092 Significant up 1 Molecular Function:cysteine-type endopeptidase inhibitor activity (GO:0004869) -- -- -- -- -- -- IPR000010 [Cystatin domain] -- -- Q5K4Q9 AAM-B protein Mettl7a1 915.9 830.6 828.7 1337.6 1357.9 1425.7 0.624866543725129 0.000193288106505451 -0.678379996736709 Significant down 2 Biological Process:metabolic process (GO:0008152),Molecular Function:methyltransferase activity (GO:0008168) -- -- -- Predicted methyltransferase R General function prediction only ; IPR013216 [Methyltransferase type 11] -- -- Q3UYV9 Nuclear cap-binding protein subunit 1 Ncbp1 1270.8 1331.6 1362.8 1015 984.2 1144.8 1.26119592875318 0.00818284238829319 0.334792418000142 Nonsignificant None 3 Molecular Function:RNA binding (GO:0003723),Molecular Function:protein binding (GO:0005515),Biological Process:RNA metabolic process (GO:0016070) nuclear cap-binding protein subunit 1 -- ko03013 RNA transport ko03015 mRNA surveillance pathway ko03040 Spliceosome Nuclear cap-binding complex, subunit NCBP1/CBP80 A RNA processing and modification ; IPR003890 [MIF4G-like, type 3] ; IPR015172[MIF4G-like, type 1] ; IPR015174[MIF4G-like, type 2] -- -- Q3UIR3 E3 ubiquitin-protein ligase DTX3L Dtx3l 1043.3 1156.4 1194.9 1047.1 1118.9 1082 1.0451354679803 0.383701364642669 0.0636899531354936 Nonsignificant None -- -- deltex 2.3.2.27 ko04330 Notch signaling pathway -- -- -- -- -- -- Q05B38 Krt6b protein (Fragment) Krt6b 699.2 657.5 385.8 976.5 333.8 349 1.05014162598686 0.91115592336155 0.0705839082060664 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) type II keratin, basic -- -- -- -- -- IPR001664 [Intermediate filament protein] ; IPR032444[Keratin type II head] -- -- Q8BL97 Serine/arginine-rich splicing factor 7 Srsf7 2351.6 2296.8 2378.8 2243.3 2195 2257.8 1.04944669285106 0.022835950297207 0.0696288861035114 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) splicing factor, arginine/serine-rich 7 -- ko03040 Spliceosome ko05168 Herpes simplex infection Alternative splicing factor SRp20/9G8 (RRM superfamily) A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- O55106 Striatin Strn 1829.9 1825.6 1881 1813.8 1848.9 1773.2 1.01850659504406 0.300088099220533 0.0264553220873585 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) striatin 1/3/4 -- Cell-cycle nuclear protein, contains WD-40 repeats D Cell cycle control, cell division, chromosome partitioning ; IPR001680 [WD40 repeat] ; IPR013258[Striatin, N-terminal] -- -- B0LAC2 Ubiquitin A-52 residue ribosomal protein fusion product 1 (Fragment) Uba52 132 118.8 173.6 186.2 189.5 165.5 0.784183296378418 0.0983955811390798 -0.350737183061772 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) large subunit ribosomal protein L40e -- ko03010 Ribosome Ubiquitin/60s ribosomal protein L40 fusion J Translation, ribosomal structure and biogenesis ; IPR000626 [Ubiquitin domain] -- -- Q00915 Retinol-binding protein 1 Rbp1 1424 1453.6 2262 1705.2 1938.3 1840.5 0.937199124726477 0.705494131191315 -0.0935724880543897 Nonsignificant None -- -- -- -- -- Fatty acid-binding protein FABP I Lipid transport and metabolism ; IPR000566 [Lipocalin/cytosolic fatty-acid binding domain] -- -- Q8BU31 Ras-related protein Rap-2c Rap2c 271 248.8 204.4 200.3 213.6 208.8 1.16299983940903 0.165326216495296 0.217850897598905 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rap-2C -- ko04530 Tight junction Ras-related GTPase R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- Q61194 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha Pik3c2a 1194 1120.3 1066.3 1129.4 1133.3 1145.5 0.991901883692272 0.827624605961446 -0.011730674790665 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Molecular Function:kinase activity (GO:0016301),Molecular Function:phosphatidylinositol binding (GO:0035091) phosphatidylinositol-4-phosphate 3-kinase 2.7.1.154 ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system Phosphoinositide 3-kinase T Signal transduction mechanisms ; IPR000008 [C2 domain] ; IPR000341[Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain] ; IPR000403[Phosphatidylinositol 3-/4-kinase, catalytic domain] ; IPR001263[Phosphoinositide 3-kinase, accessory (PIK) domain] ; IPR001683[Phox homologous domain] ; IPR002420[Phosphatidylinositol 3-kinase, C2 domain] -- -- Q8BKE6 Cytochrome P450 20A1 Cyp20a1 947.7 954.8 1044.1 1065.3 1027.8 1009.4 0.949750201450443 0.21293563128638 -0.0743799819886153 Nonsignificant None 3 Molecular Function:iron ion binding (GO:0005506),Molecular Function:heme binding (GO:0020037),Biological Process:oxidation-reduction process (GO:0055114) cytochrome P450 family 20 subfamily A -- -- Cytochrome P450 CYP4/CYP19/CYP26 subfamilies QI Secondary metabolites biosynthesis, transport and catabolism ; Lipid transport and metabolism ; IPR001128 [Cytochrome P450] -- -- D3Z2F6 Glia maturation factor gamma (Fragment) Gmfg 1126.4 1305.3 1086.4 898.6 947.6 890.4 1.28557333918 0.020097201331344 0.362411915152692 Nonsignificant None 2 Molecular Function:actin binding (GO:0003779),Cellular Component:intracellular (GO:0005622) -- -- -- Glia maturation factor beta W Extracellular structures ; IPR002108 [Actin-depolymerising factor homology domain] -- -- Q549A5 Clusterin Clu 1969.4 2054.7 1767.8 1477 1574.3 1552.9 1.25796012336562 0.0117172911966265 0.331086190313795 Nonsignificant None -- -- clusterin -- ko04610 Complement and coagulation cascades -- -- -- IPR000753 [Clusterin-like] -- -- P35822 Receptor-type tyrosine-protein phosphatase kappa Ptprk 929.3 930.4 1058.9 1043.7 1126.5 1037.7 0.909816390785249 0.135497986008266 -0.136352669170096 Nonsignificant None 4 Molecular Function:protein tyrosine phosphatase activity (GO:0004725),Molecular Function:protein binding (GO:0005515),Biological Process:protein dephosphorylation (GO:0006470),Cellular Component:membrane (GO:0016020) receptor-type tyrosine-protein phosphatase kappa 3.1.3.48 -- Protein tyrosine phosphatase T Signal transduction mechanisms ; IPR000242 [PTP type protein phosphatase] ; IPR000998[MAM domain] ; IPR003961[Fibronectin type III] ; IPR013098[Immunoglobulin I-set] -- -- Q9CQW1 Synaptobrevin homolog YKT6 Ykt6 1122.6 1062.1 1125.1 996.9 1041.3 1064.1 1.0668858588789 0.0723650702756593 0.0934058372328683 Nonsignificant None 2 Cellular Component:integral component of membrane (GO:0016021),Biological Process:vesicle-mediated transport (GO:0016192) synaptobrevin homolog YKT6 -- ko04130 SNARE interactions in vesicular transport SNARE protein YKT6, synaptobrevin/VAMP syperfamily U Intracellular trafficking, secretion, and vesicular transport ; IPR001388 [Synaptobrevin] ; IPR010908[Longin domain] -- -- E9QAJ9 Rho GTPase-activating protein 17 Arhgap17 749 742.8 736.6 799 859.3 816.1 0.900581959262852 0.0109741970314527 -0.151070517432688 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Cellular Component:cytoplasm (GO:0005737),Biological Process:signal transduction (GO:0007165) Rho GTPase-activating protein 17 -- ko04530 Tight junction GTPase-activator protein T Signal transduction mechanisms ; IPR000198 [Rho GTPase-activating protein domain] ; IPR004148[BAR domain] -- -- Q9Z1M8 Protein Red Ik 1307.9 1349.1 1332.6 1269.4 1343.2 1303.7 1.01871664581365 0.374243887582381 0.0267528242939121 Nonsignificant None 1 Cellular Component:nucleus (GO:0005634) IK cytokine -- -- IK cytokine down-regulator of HLA class II T Signal transduction mechanisms ; IPR012492 [Protein RED, C-terminal] ; IPR012916[RED-like, N-terminal] -- -- Q8C7R4 Ubiquitin-like modifier-activating enzyme 6 Uba6 1355.2 1351.3 1613.9 1735.5 1722.6 1594.7 0.855050664977834 0.0670772737567462 -0.225918187231898 Nonsignificant None 1 Molecular Function:small protein activating enzyme activity (GO:0008641) ubiquitin-activating enzyme E1-like protein 2 6.2.1.45 ko04120 Ubiquitin mediated proteolysis Ubiquitin activating enzyme UBA1 O Posttranslational modification, protein turnover, chaperones ; IPR000594 [THIF-type NAD/FAD binding fold] ; IPR018965[Ubiquitin-activating enzyme E1, C-terminal] ; IPR019572[Ubiquitin-activating enzyme, catalytic cysteine domain] ; IPR032418[Ubiquitin-activating enzyme E1, FCCH domain] ; IPR032420[Ubiquitin-activating enzyme E1, four-helix bundle] -- -- P61620 Protein transport protein Sec61 subunit alpha isoform 1 Sec61a1 2016.1 2203.9 2101.6 1904.6 1811.3 1922.4 1.12118901087207 0.0239589862675725 0.165029509242177 Nonsignificant None 2 Biological Process:protein transport (GO:0015031),Cellular Component:membrane (GO:0016020) protein transport protein SEC61 subunit alpha -- ko03060 Protein export ko04141 Protein processing in endoplasmic reticulum ko04145 Phagosome Transport protein Sec61, alpha subunit UO Intracellular trafficking, secretion, and vesicular transport ; Posttranslational modification, protein turnover, chaperones ; IPR002208 [SecY/SEC61-alpha family] ; IPR019561[Translocon Sec61/SecY, plug domain] -- -- Q91WD9 Secretagogin Scgn 715.9 654 1058.9 990.6 1091.3 1089.8 0.765772298767223 0.130073591382383 -0.385012622155527 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) -- -- -- Calmodulin and related proteins (EF-Hand superfamily) T Signal transduction mechanisms ; IPR002048 [EF-hand domain] -- -- Q9CQF0 39S ribosomal protein L11, mitochondrial Mrpl11 1124.6 1158.2 1232.8 1100.5 1236.5 1199.6 0.994062093536165 0.898804931355704 -0.00859212314125786 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L11 -- ko03010 Ribosome Mitochondrial/chloroplast ribosomal protein L11 J Translation, ribosomal structure and biogenesis ; IPR020783 [Ribosomal protein L11, C-terminal] ; IPR020784[Ribosomal protein L11, N-terminal] -- -- O54865 Guanylate cyclase soluble subunit beta-1 Gucy1b1 1277.4 1206.2 1274.6 1172.9 1180.2 1217.2 1.05262863064728 0.0813051987605047 0.0739965406151033 Nonsignificant None 6 Molecular Function:guanylate cyclase activity (GO:0004383),Biological Process:cGMP biosynthetic process (GO:0006182),Biological Process:cyclic nucleotide biosynthetic process (GO:0009190),Molecular Function:phosphorus-oxygen lyase activity (GO:0016849),Molecular Function:heme binding (GO:0020037),Biological Process:intracellular signal transduction (GO:0035556) guanylate cyclase soluble subunit beta 4.6.1.2 ko00230 Purine metabolism ko04022 cGMP-PKG signaling pathway ko04270 Vascular smooth muscle contraction ko04540 Gap junction ko04611 Platelet activation ko04713 Circadian entrainment ko04730 Long-term depression ko04921 Oxytocin signaling pathway ko04924 Renin secretion ko04970 Salivary secretion Adenylate/guanylate kinase F Nucleotide transport and metabolism ; IPR001054 [Adenylyl cyclase class-3/4/guanylyl cyclase] ; IPR011644[Heme-NO binding] ; IPR011645[Haem NO binding associated] -- -- Q8VE70 Programmed cell death protein 10 Pdcd10 2411.7 2394.3 2849.7 2649.1 2714.6 2850.5 0.932007986170291 0.310223212748896 -0.101585777820134 Nonsignificant None -- -- programmed cell death protein 10 -- -- Putative apoptosis related protein S Function unknown ; -- -- -- Q9D1P4 Cysteine and histidine-rich domain-containing protein 1 Chordc1 1674.7 1723.4 1660.6 1570 1659.3 1506.5 1.06818277798894 0.0894412313566642 0.0951585293630472 Nonsignificant None -- -- cysteine and histidine-rich domain-containing protein 1 -- -- Zn2+-binding protein Melusin/RAR1, contains CHORD domain R General function prediction only ; IPR007051 [CHORD domain] ; IPR007052[CS domain] -- -- Q8R2K1 Fucose mutarotase Fuom 1143.3 1091.7 1689.2 1795.9 1735.7 1772.8 0.739800919990951 0.136672336864232 -0.434791000338461 Nonsignificant None 3 Biological Process:monosaccharide metabolic process (GO:0005996),Molecular Function:isomerase activity (GO:0016853),Molecular Function:monosaccharide binding (GO:0048029) L-fucose mutarotase 5.1.3.29 -- -- -- -- IPR007721 [D-ribose pyranase RbsD/L-fucose mutarotase FucU] -- -- P54116 Stomatin Stom 1000.6 1050.4 970.2 1050 1057.8 1057.6 0.954444935869085 0.1746459264909 -0.0672661272635119 Nonsignificant None -- -- erythrocyte band 7 integral membrane protein -- -- Prohibitins and stomatins of the PID superfamily C Energy production and conversion ; IPR001107 [Band 7 domain] -- -- Q8CGF7 Transcription elongation regulator 1 Tcerg1 3045.9 3012.2 3352.3 3070.8 3175.7 3148.7 1.00161784741144 0.966286250495356 0.00233217439453307 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) transcription elongation regulator 1 -- ko03040 Spliceosome Transcription factor CA150 K Transcription ; IPR001202 [WW domain] ; IPR002713[FF domain] -- -- Q6PHU5 Sortilin Sort1 1587.6 1443.1 1551.3 1739.8 1816.3 1841.6 0.848880078551976 0.00688548738625458 -0.236367336513487 Nonsignificant None -- -- sortilin -- ko04142 Lysosome ko04722 Neurotrophin signaling pathway ko04979 Cholesterol metabolism Sortilin and related receptors R General function prediction only ; IPR031777 [Sortilin, C-terminal] ; IPR031778[Sortilin, N-terminal] -- -- Q6ZQB6 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 Ppip5k2 489.8 525 508 580.1 532.9 551.6 0.914814369818575 0.0504393831735868 -0.128449067240998 Nonsignificant None 1 Molecular Function:acid phosphatase activity (GO:0003993) inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase 2.7.4.24 ko04070 Phosphatidylinositol signaling system Arp2/3 complex-interacting protein VIP1/Asp1, involved in regulation of actin cytoskeleton Z Cytoskeleton ; IPR000560 [Histidine phosphatase superfamily, clade-2] -- -- Q9ES74 Serine/threonine-protein kinase Nek7 Nek7 1375.5 1368.4 1272.1 1328 1308.3 1357.1 1.00565933790755 0.845456766038917 0.00814168213770866 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) NIMA (never in mitosis gene a)-related kinase 7 2.7.11.1 ko04621 NOD-like receptor signaling pathway NIMA (never in mitosis)-related G2-specific serine/threonine protein kinase D Cell cycle control, cell division, chromosome partitioning ; IPR000719 [Protein kinase domain] -- -- Q8VE88 Protein FAM114A2 Fam114a2 1015.6 947.1 1009.2 996.9 976.5 974.7 1.00807299616702 0.747267786367783 0.0116001104600513 Nonsignificant None -- -- -- -- -- -- -- -- IPR007998 [Protein of unknown function DUF719] -- -- Q9CQU0 Thioredoxin domain-containing protein 12 Txndc12 1838.1 1864.6 1918.9 1974.4 1967.9 1977.1 0.949690847045309 0.0511780746411893 -0.0744701456776 Nonsignificant None -- -- protein-disulfide reductase (glutathione) 1.8.4.2 ko00480 Glutathione metabolism -- -- -- -- -- -- Q8VED5 Keratin, type II cytoskeletal 79 Krt79 505.3 650.5 648.4 617.1 642.5 562.7 0.990067497119025 0.915657847511137 -0.0144012116754299 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) type II keratin, basic -- -- -- -- -- IPR001664 [Intermediate filament protein] ; IPR032444[Keratin type II head] -- -- Q4FZH2 Ribosomal protein L26 Rpl26 5659.7 5622.8 5120.6 4393.3 4428.2 4447.5 1.2361971512548 0.0257856371602403 0.305908845552753 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Biological Process:translation (GO:0006412),Cellular Component:large ribosomal subunit (GO:0015934) large subunit ribosomal protein L26e -- ko03010 Ribosome 60S ribosomal protein L26 J Translation, ribosomal structure and biogenesis ; IPR005756 [Ribosomal protein L26/L24P, eukaryotic/archaeal] ; IPR005824[KOW] -- -- Q9CQ48 NudC domain-containing protein 2 Nudcd2 917.7 908.9 907.2 836.3 860.8 871.7 1.06423232637808 0.00739818818719186 0.0898131315963197 Nonsignificant None -- -- -- -- -- Nuclear distribution protein NUDC T Signal transduction mechanisms ; IPR007052 [CS domain] -- -- P46660 Alpha-internexin Ina 885.5 822.1 1199.8 1282.2 1103.8 1195.1 0.811873446706319 0.153304164208173 -0.30067323451928 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) internexin neuronal intermediate filament protein, alpha -- -- -- -- -- IPR001664 [Intermediate filament protein] ; IPR006821[Intermediate filament head, DNA-binding domain] -- -- Q059T9 PRP4 pre-mRNA processing factor 4 homolog (Yeast) Prpf4 1624.1 1693.9 1523.5 1488.4 1570.5 1521.7 1.05695760380736 0.188369865550668 0.0799175091675567 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) U4/U6 small nuclear ribonucleoprotein PRP4 -- ko03040 Spliceosome U4/U6 small nuclear ribonucleoprotein Prp4 (contains WD40 repeats) A RNA processing and modification ; IPR001680 [WD40 repeat] ; IPR014906[Pre-mRNA processing factor 4 (PRP4)-like] -- -- Q8BRH0 Protein O-mannosyl-transferase TMTC3 Tmtc3 1169.3 1215.1 893.8 851.8 885.8 840.2 1.27170455427108 0.143065652287348 0.346763538864014 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- FOG: TPR repeat R General function prediction only ; IPR001440 [Tetratricopeptide repeat 1] ; IPR013618[Domain of unknown function DUF1736] ; IPR019734[Tetratricopeptide repeat] -- -- Q63810 Calcineurin subunit B type 1 Ppp3r1 1176.2 1215.9 1279 1422.2 1406.3 1479.1 0.852237905097966 0.00467386938295807 -0.230671875006157 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) serine/threonine-protein phosphatase 2B regulatory subunit -- ko04010 MAPK signaling pathway ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04114 Oocyte meiosis ko04218 Cellular senescence ko04310 Wnt signaling pathway ko04360 Axon guidance ko04370 VEGF signaling pathway ko04380 Osteoclast differentiation ko04650 Natural killer cell mediated cytotoxicity ko04658 Th1 and Th2 cell differentiation ko04659 Th17 cell differentiation ko04660 T cell receptor signaling pathway ko04662 B cell receptor signaling pathway ko04720 Long-term potentiation ko04724 Glutamatergic synapse ko04921 Oxytocin signaling pathway ko04922 Glucagon signaling pathway ko04924 Renin secretion ko05010 Alzheimer's disease ko05014 Amyotrophic lateral sclerosis (ALS) ko05031 Amphetamine addiction ko05152 Tuberculosis ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection Ca2+/calmodulin-dependent protein phosphatase (calcineurin subunit B), EF-Hand superfamily protein T Signal transduction mechanisms ; IPR002048 [EF-hand domain] -- -- Q9D375 AB hydrolase-1 domain-containing protein Abhd6 748 684.9 969.9 858.7 829.3 834.1 0.952698148368423 0.691282337506441 -0.0699089099579247 Nonsignificant None -- -- abhydrolase domain-containing protein 6 3.1.1.23 ko04723 Retrograde endocannabinoid signaling Predicted hydrolase/acyltransferase (alpha/beta hydrolase superfamily) R General function prediction only ; IPR000073 [Alpha/beta hydrolase fold-1] -- -- Q69ZN1 MKIAA1252 protein (Fragment) Sgpl1 970.6 1120.3 1131.7 1194.3 1251.2 1154.3 0.895216400911162 0.100206588746756 -0.159691627276752 Nonsignificant None 3 Molecular Function:carboxy-lyase activity (GO:0016831),Biological Process:carboxylic acid metabolic process (GO:0019752),Molecular Function:pyridoxal phosphate binding (GO:0030170) sphinganine-1-phosphate aldolase 4.1.2.27 ko00600 Sphingolipid metabolism ko01100 Metabolic pathways ko04071 Sphingolipid signaling pathway Glutamate decarboxylase/sphingosine phosphate lyase E Amino acid transport and metabolism ; IPR002129 [Pyridoxal phosphate-dependent decarboxylase] -- -- Q6PIP5 NudC domain-containing protein 1 Nudcd1 1878 1839.5 1395.5 1376.1 1374.7 1347.7 1.24752958399414 0.160117587019624 0.319074028128124 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein (tumor antigen CML66 in humans) S Function unknown ; IPR007052 [CS domain] -- -- P11031 Activated RNA polymerase II transcriptional coactivator p15 Sub1 4674.7 4795.3 4321.9 3910.8 3916.1 3952.5 1.17084910946228 0.0409964295463527 0.227555163749485 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Molecular Function:transcription coactivator activity (GO:0003713) -- -- -- Transcriptional coactivator K Transcription ; IPR003173 [Transcriptional coactivator p15 (PC4)] -- PC4 Q9DBE8 Alpha-1,3/1,6-mannosyltransferase ALG2 Alg2 844 911.9 985 922.2 914.1 1039.7 0.953025034770514 0.477185714196759 -0.0694139824678999 Nonsignificant None -- -- -- -- ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways Glycosyltransferase M Cell wall/membrane/envelope biogenesis ; IPR001296 [Glycosyl transferase, family 1] ; IPR028098[Glycosyltransferase subfamily 4-like, N-terminal domain] -- -- B2RXQ2 Ppfia1 protein Ppfia1 587.6 579.7 566.8 609.2 636.8 629.2 0.924754692832764 0.0100235229962195 -0.112857378305999 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- LAR-interacting protein and related proteins R General function prediction only ; IPR001660 [Sterile alpha motif domain] -- -- Q922J9 Fatty acyl-CoA reductase 1 Far1 2177 2238.3 1897.7 1529.7 1628.8 1566.2 1.33616949224289 0.00822731569212034 0.418103024360376 Nonsignificant None -- -- alcohol-forming fatty acyl-CoA reductase 1.2.1.84 ko04146 Peroxisome Acyl-CoA reductase I Lipid transport and metabolism ; IPR013120 [Male sterility, NAD-binding] ; IPR033640[Fatty acyl-CoA reductase, C-terminal] -- -- A0A0A6YY75 Complement component receptor 1-like protein Cr1l 1294.9 1353.4 1571.9 1744 1764.4 1655.5 0.817250527701931 0.025604655740359 -0.291149691340569 Nonsignificant None -- -- complement receptor related protein -- -- -- -- -- IPR000436 [Sushi/SCR/CCP domain] -- -- Q3UVL4 Vacuolar protein sorting-associated protein 51 homolog Vps51 273 244.2 284.9 295.7 290.2 298.3 0.907147704139335 0.0904006769368585 -0.140590621663556 Nonsignificant None -- -- vacuolar protein sorting-associated protein 51 -- -- Uncharacterized conserved protein S Function unknown ; -- -- -- O70311 Glycylpeptide N-tetradecanoyltransferase 2 Nmt2 81.8 71.5 75.6 55.2 50.6 88.1 1.18050541516245 0.392444019968854 0.239404659448894 Nonsignificant None 1 Molecular Function:glycylpeptide N-tetradecanoyltransferase activity (GO:0004379) glycylpeptide N-tetradecanoyltransferase 2.3.1.97 -- N-myristoyl transferase I Lipid transport and metabolism ; IPR022676 [Myristoyl-CoA:protein N-myristoyltransferase, N-terminal] ; IPR022677[Myristoyl-CoA:protein N-myristoyltransferase, C-terminal] -- -- Q542M2 Coatomer subunit zeta Copz1 1872 1812.9 1882.3 1852.3 1949.7 1861.2 0.983048453171352 0.445685071223498 -0.0246655680190862 Nonsignificant None -- -- coatomer subunit zeta -- -- Vesicle coat complex COPI, zeta subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR022775 [AP complex, mu/sigma subunit] -- -- Q91VK1 eIF5-mimic protein 1 Bzw2 1641.9 1621.7 1710.1 1524.6 1624.4 1496 1.07076426264801 0.0811144898950947 0.0986408941465461 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Predicted translation factor, contains W2 domain J Translation, ribosomal structure and biogenesis ; IPR003307 [W2 domain] -- -- Q2UZW7 Microtubule-associated protein Mapre3 841 809 880.6 924.8 919.5 919.9 0.915490919615078 0.0630727150190102 -0.127382518303596 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:microtubule binding (GO:0008017) microtubule-associated protein, RP/EB family -- -- Microtubule-binding protein involved in cell cycle control DZ Cell cycle control, cell division, chromosome partitioning ; Cytoskeleton ; IPR001715 [Calponin homology domain] ; IPR004953[EB1, C-terminal] -- -- Q3UDK3 AAA domain-containing protein Rfc5 515.6 510.8 523.1 400.5 420.3 418.7 1.25010084711577 0.000143770552956275 0.322044483499493 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) replication factor C subunit 3/5 -- ko03030 DNA replication ko03420 Nucleotide excision repair ko03430 Mismatch repair Replication factor C, subunit RFC5 L Replication, recombination and repair ; IPR003959 [ATPase, AAA-type, core] ; IPR013748[Replication factor C, C-terminal] -- -- Q3UGY8 Brefeldin A-inhibited guanine nucleotide-exchange protein 3 Arfgef3 315.8 315.5 396.5 446.9 449.3 451.9 0.762406349677324 0.0578173163416966 -0.391367960149163 Nonsignificant None -- -- brefeldin A-inhibited guanine nucleotide-exchange protein 3 -- -- Uncharacterized conserved protein, contains Sec7 domain U Intracellular trafficking, secretion, and vesicular transport ; IPR015403 [Sec7, C-terminal] ; IPR032629[Mon2, dimerisation and cyclophilin-binding domain] -- -- Q9WU28 Prefoldin subunit 5 Pfdn5 823.8 851.8 802.3 818.6 797.5 813 1.02008974517311 0.357544662153078 0.0286960828051701 Nonsignificant None -- -- prefoldin alpha subunit -- -- Molecular chaperone Prefoldin, subunit 5 O Posttranslational modification, protein turnover, chaperones ; IPR004127 [Prefoldin alpha-like] -- -- Q99JG3 Annexin A13 Anxa13 542.5 533.4 719.9 868.5 743.4 934.6 0.705203220106028 0.0388494105216364 -0.503889032565639 Nonsignificant None 2 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:calcium-dependent phospholipid binding (GO:0005544) annexin A13 -- -- Annexin U Intracellular trafficking, secretion, and vesicular transport ; IPR018502 [Annexin repeat] -- -- P62900 60S ribosomal protein L31 Rpl31 2974.4 3350 2953.9 2724.8 2799.8 2575.2 1.14549741968938 0.0532627691616887 0.195974208877826 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L31e -- ko03010 Ribosome 60S ribosomal protein L31 J Translation, ribosomal structure and biogenesis ; IPR000054 [Ribosomal protein L31e] -- -- Q91UZ1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase Plcb4 798.1 824 876.7 1021.7 1026 1005.4 0.818446824538993 0.00152233362501607 -0.289039408751161 Nonsignificant None 5 Molecular Function:phosphatidylinositol phospholipase C activity (GO:0004435),Molecular Function:protein binding (GO:0005515),Biological Process:lipid metabolic process (GO:0006629),Biological Process:signal transduction (GO:0007165),Biological Process:intracellular signal transduction (GO:0035556) phosphatidylinositol phospholipase C, beta 3.1.4.11 ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04015 Rap1 signaling pathway ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04062 Chemokine signaling pathway ko04070 Phosphatidylinositol signaling system ko04071 Sphingolipid signaling pathway ko04072 Phospholipase D signaling pathway ko04261 Adrenergic signaling in cardiomyocytes ko04270 Vascular smooth muscle contraction ko04310 Wnt signaling pathway ko04371 Apelin signaling pathway ko04540 Gap junction ko04611 Platelet activation ko04621 NOD-like receptor signaling pathway ko04713 Circadian entrainment ko04720 Long-term potentiation ko04723 Retrograde endocannabinoid signaling ko04724 Glutamatergic synapse ko04725 Cholinergic synapse ko04726 Serotonergic synapse ko04728 Dopaminergic synapse ko04730 Long-term depression ko04750 Inflammatory mediator regulation of TRP channels ko04911 Insulin secretion ko04912 GnRH signaling pathway ko04915 Estrogen signaling pathway ko04916 Melanogenesis ko04918 Thyroid hormone synthesis ko04919 Thyroid hormone signaling pathway ko04921 Oxytocin signaling pathway ko04922 Glucagon signaling pathway ko04924 Renin secretion ko04925 Aldosterone synthesis and secretion ko04926 Relaxin signaling pathway ko04933 AGE-RAGE signaling pathway in diabetic complications ko04961 Endocrine and other factor-regulated calcium reabsorption ko04970 Salivary secretion ko04971 Gastric acid secretion ko04972 Pancreatic secretion ko05010 Alzheimer's disease ko05016 Huntington's disease ko05142 Chagas disease (American trypanosomiasis) ko05143 African trypanosomiasis ko05146 Amoebiasis ko05200 Pathways in cancer Phospholipase C I Lipid transport and metabolism ; IPR000008 [C2 domain] ; IPR000909[Phosphatidylinositol-specific phospholipase C, X domain] ; IPR001711[Phospholipase C, phosphatidylinositol-specific, Y domain] ; IPR009535[Phospholipase C-beta, conserved site] ; IPR015359[Phosphoinositide-specific phospholipase C, EF-hand-like domain] -- -- Q80WQ2 Protein VAC14 homolog Vac14 1772.7 1321.2 1427.6 1451.6 1431.5 1481.7 1.0359008431085 0.739062132059184 0.0508859142194782 Nonsignificant None -- -- vacuole morphology and inheritance protein 14 -- ko05166 HTLV-I infection ko05203 Viral carcinogenesis Uncharacterized conserved protein S Function unknown ; IPR021841 [Vacuolar protein 14 C-terminal Fig4-binding domain] ; IPR032878[Vacuole morphology and inheritance protein 14, Fab1-binding region] -- -- G3UW85 Enhancer of rudimentary homolog Erh 1638.7 1716.8 1760.3 1818.5 1829.9 1828 0.93415382367979 0.0761414612723723 -0.0982679620963537 Nonsignificant None 3 Biological Process:pyrimidine nucleotide biosynthetic process (GO:0006221),Biological Process:cell cycle (GO:0007049),Biological Process:positive regulation of Notch signaling pathway (GO:0045747) -- -- -- Enhancer of rudimentary R General function prediction only ; IPR000781 [Enhancer of rudimentary] -- -- Q80YU9 Retinoblastoma binding protein 9 Rbbp9 1469.8 1534.2 2222.2 2253.9 2120.3 2480.9 0.762381292760135 0.107692747987746 -0.391415375919288 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) uncharacterized protein -- -- -- -- -- IPR010662 [Putative hydrolase RBBP9/YdeN] -- -- J7NNX8 Interferon-gamma-inducible GTPase Ifgga1 protein Iigp1 1797.4 2399.3 2143.6 1203.1 1318 1274.9 1.67025816649104 0.00880511069805458 0.740071112717433 Significant up 2 Molecular Function:GTP binding (GO:0005525),Cellular Component:membrane (GO:0016020) -- -- -- -- -- -- IPR007743 [Immunity-related GTPases-like] -- -- Q9DB27 Malignant T-cell-amplified sequence 1 Mcts1 994.4 988.7 1163.6 1044.3 1102.7 1071.4 0.977721849366145 0.709839634719128 -0.0325040015047164 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) PUA domain protein -- -- Predicted RNA-binding protein with PUA domain J Translation, ribosomal structure and biogenesis ; IPR002478 [PUA domain] -- -- B2RWS6 Histone acetyltransferase p300 Ep300 215.1 254.3 254.1 205.8 220.6 207.2 1.14188762626263 0.0966768423590015 0.191420681339477 Nonsignificant None 8 Cellular Component:histone acetyltransferase complex (GO:0000123),Molecular Function:transcription cofactor activity (GO:0003712),Molecular Function:transcription coactivator activity (GO:0003713),Molecular Function:histone acetyltransferase activity (GO:0004402),Molecular Function:protein binding (GO:0005515),Cellular Component:nucleus (GO:0005634),Molecular Function:zinc ion binding (GO:0008270),Biological Process:histone acetylation (GO:0016573) E1A/CREB-binding protein 2.3.1.48 ko04024 cAMP signaling pathway ko04066 HIF-1 signaling pathway ko04068 FoxO signaling pathway ko04110 Cell cycle ko04310 Wnt signaling pathway ko04330 Notch signaling pathway ko04350 TGF-beta signaling pathway ko04520 Adherens junction ko04630 Jak-STAT signaling pathway ko04720 Long-term potentiation ko04916 Melanogenesis ko04919 Thyroid hormone signaling pathway ko04922 Glucagon signaling pathway ko05016 Huntington's disease ko05152 Tuberculosis ko05161 Hepatitis B ko05164 Influenza A ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05206 MicroRNAs in cancer ko05211 Renal cell carcinoma ko05215 Prostate cancer CREB binding protein/P300 and related TAZ Zn-finger proteins K Transcription ; IPR000197 [Zinc finger, TAZ-type] ; IPR000433[Zinc finger, ZZ-type] ; IPR001487[Bromodomain] ; IPR003101[Coactivator CBP, KIX domain] ; IPR010303[CREB-binding protein/p300, atypical RING domain] ; IPR013178[Histone acetyltransferase Rtt109/CBP] ; IPR014744[Nuclear receptor coactivator, CREB-bp-like, interlocking] -- -- Q9DBN5 Lon protease homolog 2, peroxisomal Lonp2 660.5 596.8 601.4 649.1 649.9 675.9 0.941161577801408 0.157676990829319 -0.0874856700400142 Nonsignificant None 4 Molecular Function:ATP-dependent peptidase activity (GO:0004176),Molecular Function:serine-type endopeptidase activity (GO:0004252),Molecular Function:ATP binding (GO:0005524),Biological Process:proteolysis (GO:0006508) ATP-dependent Lon protease 3.4.21.53 Mitochondrial ATP-dependent protease PIM1/LON O Posttranslational modification, protein turnover, chaperones ; IPR003111 [ATP-dependent protease La (LON), substrate-binding domain] ; IPR003959[ATPase, AAA-type, core] ; IPR008269[Peptidase S16, Lon C-terminal] -- -- Q3ULN6 Sacchrp_dh_NADP domain-containing protein Sccpdh 1044.5 1029.5 1077.3 1061.2 1088.4 1106 0.967962894704509 0.144574721188037 -0.0469763497137389 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) -- -- -- Uncharacterized membrane protein S Function unknown ; IPR005097 [Saccharopine dehydrogenase, NADP binding domain] -- -- Q80UL3 Galactokinase 1 Galk1 1362.7 1463.6 1774.9 1706.6 1673.1 1660.3 0.912936507936508 0.359471442523811 -0.13141356640876 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) galactokinase 2.7.1.6 ko00052 Galactose metabolism ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways Galactokinase G Carbohydrate transport and metabolism ; IPR006204 [GHMP kinase N-terminal domain] ; IPR013750[GHMP kinase, C-terminal domain] ; IPR019539[Galactokinase galactose-binding domain] -- -- O89112 Glutathione S-transferase LANCL1 Lancl1 605 602.5 666.8 630.9 590.1 676.4 0.987825445346263 0.824939550886056 -0.0176719633829309 Nonsignificant None -- -- -- -- -- Lanthionine synthetase C-like protein 1 V Defense mechanisms ; IPR007822 [Lanthionine synthetase C-like] -- -- Q99JF8 PC4 and SFRS1-interacting protein Psip1 1407.8 1403.9 1561.4 1563.1 1545.4 1529.9 0.942803552949293 0.168902137810422 -0.0849708995017989 Nonsignificant None -- -- -- -- -- Transcription coactivator K Transcription ; IPR000313 [PWWP domain] ; IPR021567[Lens epithelium-derived growth factor (LEDGF)] -- -- O88307 Sortilin-related receptor Sorl1 1206.7 1209.8 1144.3 1208.3 1332.4 1273.1 0.933661964444911 0.113231575053284 -0.0990277831663856 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains T Signal transduction mechanisms ; IPR000033 [LDLR class B repeat] ; IPR002172[Low-density lipoprotein (LDL) receptor class A repeat] ; IPR003961[Fibronectin type III] ; IPR031777[Sortilin, C-terminal] ; IPR031778[Sortilin, N-terminal] -- -- Q9QUK9 TESP4 Try5 125 125.6 101.7 142.9 172.2 142.8 0.769381961126884 0.048630031097106 -0.378228090178583 Nonsignificant None 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) trypsin 3.4.21.4 ko04080 Neuroactive ligand-receptor interaction ko04972 Pancreatic secretion ko04974 Protein digestion and absorption ko05164 Influenza A Trypsin E Amino acid transport and metabolism ; IPR001254 [Serine proteases, trypsin domain] -- -- O35465 Peptidyl-prolyl cis-trans isomerase FKBP8 Fkbp8 865.8 825.8 846.8 836.3 818.3 815.8 1.02752590673575 0.161916687522082 0.0391747686495574 Nonsignificant None -- -- FK506-binding protein 8 5.2.1.8 -- FKBP-type peptidyl-prolyl cis-trans isomerase O Posttranslational modification, protein turnover, chaperones ; IPR001179 [FKBP-type peptidyl-prolyl cis-trans isomerase domain] -- -- Q9D3P8 Plasminogen receptor (KT) Plgrkt 1601.6 1416.9 1450.4 1956.1 1832.1 1983.7 0.774251113151649 0.00410344656075505 -0.369126542803105 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019319 [Protein of unknown function DUF2368] -- -- Q8BX80 Cytosolic endo-beta-N-acetylglucosaminidase Engase 487.9 479.1 516.8 565.8 530.5 540.3 0.906635708175486 0.0303483114221497 -0.141405111478166 Nonsignificant None 2 Cellular Component:cytoplasm (GO:0005737),Molecular Function:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity (GO:0033925) mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase 3.2.1.96 ko00511 Other glycan degradation Predicted glycosylhydrolase R General function prediction only ; IPR005201 [Glycoside hydrolase, family 85] -- -- Q2NL51 Glycogen synthase kinase-3 alpha Gsk3a 376.1 380.7 375.3 404.8 395.6 430.7 0.919584111769962 0.0846475505679321 -0.120946554960784 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) glycogen synthase kinase 3 alpha 2.7.11.26 ko04062 Chemokine signaling pathway ko04728 Dopaminergic synapse ko04932 Non-alcoholic fatty liver disease (NAFLD) Glycogen synthase kinase-3 G Carbohydrate transport and metabolism ; IPR000719 [Protein kinase domain] -- -- Q8BP91 Uncharacterized protein Chgb 1117 1113.8 1207.5 1218.9 1354.6 1257.1 0.897587845246176 0.0615426676008019 -0.155874955172603 Nonsignificant None 1 Cellular Component:secretory granule (GO:0030141) chromogranin-B -- -- -- -- -- IPR001990 [Chromogranin A/B/C] -- -- D3Z030 F-actin-uncapping protein LRRC16A Carmil1 1507.2 1342.8 1304.8 1344.9 1404.7 1421.4 0.996116039319108 0.939006712889541 -0.00561428070751909 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) leucine-rich repeat-containing protein 16 -- -- Predicted myosin-I-binding protein N Cell motility ; IPR001611 [Leucine-rich repeat] ; IPR031943[CARMIL, C-terminal domain] -- -- Q5DTM8 E3 ubiquitin-protein ligase BRE1A Rnf20 1238.1 1198.2 1197.7 1214.9 1210.4 1123.6 1.02397926117952 0.433158153414686 0.0341864964937304 Nonsignificant None -- -- E3 ubiquitin-protein ligase BRE1 2.3.2.27 -- E3 ubiquitin ligase involved in syntaxin degradation O Posttranslational modification, protein turnover, chaperones ; -- -- -- B0V2Q7 Lclat1 protein Lclat1 1072.3 1089.3 1033.6 1159.5 1170.6 1055.5 0.943761814744801 0.189456869749003 -0.0835052946700532 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) -- -- ko00561 Glycerolipid metabolism ko00564 Glycerophospholipid metabolism ko01100 Metabolic pathways Lysophosphatidic acid acyltransferase LPAAT and related acyltransferases I Lipid transport and metabolism ; IPR002123 [Phospholipid/glycerol acyltransferase] ; IPR032098[Acyltransferase, C-terminal domain] -- -- D3Z5B1 Zinc finger, BED type-containing 5 (Fragment) Chchd2l 992.4 1091.3 1383.4 1350.4 1313.6 1200.4 0.89718973191181 0.351698644822087 -0.15651498561418 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; -- -- -- A2AJ76 Hemicentin-2 Hmcn2 411.8 402.9 535.8 412.1 382 427.8 1.10524592847205 0.394255491250689 0.144367419671758 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) hemicentin -- -- FOG: Immunoglobin and related proteins RP General function prediction only ; Inorganic ion transport and metabolism ; IPR001881 [EGF-like calcium-binding domain] ; IPR006605[G2 nidogen/fibulin G2F] ; IPR013098[Immunoglobulin I-set] ; IPR026823[Complement Clr-like EGF domain] -- -- Q9D1H9 Microfibril-associated glycoprotein 4 Mfap4 2531.6 2666.6 2653.3 2682.9 2704.1 3204.9 0.91382581268404 0.23325680543747 -0.130008900201258 Nonsignificant None -- -- -- -- -- Ficolin and related extracellular proteins R General function prediction only ; IPR002181 [Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain] -- -- Q8VE22 28S ribosomal protein S23, mitochondrial Mrps23 2372.5 2294.4 2582.4 2336.3 2464.5 2397.5 1.00708500618202 0.864741461201097 0.0101854637034556 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S23 -- -- -- -- -- IPR023611 [Ribosomal protein S23/S25, mitochondrial] -- -- Q9R0X4 Acyl-coenzyme A thioesterase 9, mitochondrial Acot9 1174.3 1109 1224.3 1376.9 1264.5 1319.3 0.885601030120938 0.0315486988742602 -0.175271194640633 Nonsignificant None -- -- acyl-coenzyme A thioesterase 9 3.1.2.- -- Acyl-CoA thioesterase I Lipid transport and metabolism ; -- -- -- E9PV45 Ubiquitinyl hydrolase 1 Usp24 454.4 456.4 436.3 467.9 465 456.4 0.969624991002663 0.124946935508705 -0.0445012117417479 Nonsignificant None 2 Biological Process:protein deubiquitination (GO:0016579),Molecular Function:thiol-dependent ubiquitinyl hydrolase activity (GO:0036459) ubiquitin carboxyl-terminal hydrolase 9/24 3.4.19.12 -- Ubiquitin carboxyl-terminal hydrolase O Posttranslational modification, protein turnover, chaperones ; IPR001394 [Peptidase C19, ubiquitin carboxyl-terminal hydrolase] -- -- E9QP49 EH domain-binding protein 1-like protein 1 Ehbp1l1 574.7 728.5 568.7 543.8 567.1 542.4 1.13222040766951 0.297161558606623 0.179154832815835 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Ca2+-binding actin-bundling protein (actinin), alpha chain (EF-Hand protein superfamily) Z Cytoskeleton ; IPR001715 [Calponin homology domain] ; IPR019448[EEIG1/EHBP1 N-terminal domain] ; IPR022735[Domain of unknown function DUF3585] -- -- Q9D071 MMS19 nucleotide excision repair protein homolog Mms19 519.1 557.6 591.5 587 629.1 637.6 0.89992986998975 0.0770300640424069 -0.152115515845214 Nonsignificant None -- -- DNA repair/transcription protein MET18/MMS19 -- -- DNA repair/transcription protein Mms19 LK Replication, recombination and repair ; Transcription ; IPR024687 [MMS19, C-terminal] -- -- A0A1L1SSH9 SPARC Sparc 799.6 1033.4 1027 981.8 994.7 871.7 1.00414296748824 0.965802783405819 0.00596469140252596 Nonsignificant None 4 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:protein binding (GO:0005515),Cellular Component:proteinaceous extracellular matrix (GO:0005578),Biological Process:signal transduction (GO:0007165) -- -- -- Matricellular protein Osteonectin/SPARC/BM-40 W Extracellular structures ; IPR002350 [Kazal domain] ; IPR015369[Follistatin/Osteonectin EGF domain] ; IPR019577[SPARC/Testican, calcium-binding domain] -- -- A2A6J7 Lymphocyte-specific protein 1 Lsp1 1518.3 1605.9 1354.5 1130.6 1206.9 1146.8 1.28539448382745 0.0127349792026771 0.362211186284546 Nonsignificant None -- -- lymphocyte-specific protein 1 -- ko05152 Tuberculosis FOG: 7 transmembrane receptor R General function prediction only ; IPR006018 [Caldesmon/lymphocyte specific protein] -- -- Q9CSU0 Regulation of nuclear pre-mRNA domain-containing protein 1B Rprd1b 1350.7 1308.3 1412 1411.5 1504.4 1409.5 0.941184630323207 0.122589729986523 -0.087450333544806 Nonsignificant None -- -- regulator of Ty1 transposition protein 103 -- -- Regulator of nuclear mRNA A RNA processing and modification ; IPR006903 [RNA polymerase II-binding domain] ; IPR032337[Cell-cycle alteration and expression-elevated protein in tumour] -- -- Q3U679 Beta-2-microglobulin B2m 1838.6 1776.9 1644.7 1733.6 1866.5 1834.9 0.967838086476541 0.451060340641163 -0.0471623814531087 Nonsignificant None -- -- beta-2-microglobulin -- ko04612 Antigen processing and presentation -- -- -- IPR003597 [Immunoglobulin C1-set] -- -- Q3THQ0 Beta-hexosaminidase Hexa 1316.5 1245.8 1329.8 1765.2 1861.9 1918.5 0.701835689555684 0.000441555917360293 -0.510794781749992 Nonsignificant None 1 Biological Process:carbohydrate metabolic process (GO:0005975) hexosaminidase 3.2.1.52 ko00511 Other glycan degradation ko00520 Amino sugar and nucleotide sugar metabolism ko00531 Glycosaminoglycan degradation ko00603 Glycosphingolipid biosynthesis - globo and isoglobo series ko00604 Glycosphingolipid biosynthesis - ganglio series ko01100 Metabolic pathways ko04142 Lysosome Beta-N-acetylhexosaminidase G Carbohydrate transport and metabolism ; IPR015883 [Glycoside hydrolase family 20, catalytic domain] ; IPR029019[Beta-hexosaminidase, eukaryotic type, N-terminal] -- -- Q3UF30 Protein S100-A10 S100a10 2459.1 2395.7 1967.2 2252 2157.8 2355 1.00845553453169 0.913390423117933 0.0121474731180834 Nonsignificant None -- -- calpactin-1 light chain -- -- -- -- -- IPR013787 [S100/CaBP-9k-type, calcium binding, subdomain] -- -- Q9QZL0 Receptor-interacting serine/threonine-protein kinase 3 Ripk3 2461.1 2693.3 1974.4 1246.4 1388.5 1309 1.80755090139202 0.00792857819774417 0.854036274646298 Significant up 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) receptor-interacting serine/threonine-protein kinase 3 2.7.11.1 ko04217 Necroptosis ko04621 NOD-like receptor signaling pathway ko04623 Cytosolic DNA-sensing pathway ko04668 TNF signaling pathway Tyrosine kinase specific for activated (GTP-bound) p21cdc42Hs T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR025735[RHIM domain] -- -- Q0VBU4 Coiled-coil domain containing 47 Ccdc47 934.1 978.1 1185.3 1125.9 1197.5 1161.2 0.888911209321013 0.182747580917444 -0.169888775123314 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR012879 [Protein of unknown function DUF1682] -- -- P47915 60S ribosomal protein L29 Rpl29 5935.1 5925.7 4486.5 4168.2 4121.7 4040.9 1.32572906867357 0.107727375393377 0.406785970610107 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L29e -- ko03010 Ribosome 60S ribosomal protein L29 J Translation, ribosomal structure and biogenesis ; IPR002673 [Ribosomal protein L29e] -- -- Q80V26 Golgi-resident adenosine 3,5-bisphosphate 3-phosphatase Bpnt2 892.7 891.3 1033.3 1033.7 976.1 1036 0.924978659137173 0.20972073687817 -0.112508014352615 Nonsignificant None 1 Biological Process:phosphatidylinositol phosphorylation (GO:0046854) -- -- ko00562 Inositol phosphate metabolism ko00920 Sulfur metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system Inositol monophosphatase T Signal transduction mechanisms ; IPR000760 [Inositol monophosphatase-like] -- -- Q148W0 Phospholipid-transporting ATPase IC Atp8b1 1099.8 989.4 1193.8 1221.2 1215.3 1257.8 0.888666323796118 0.0862593769536388 -0.17028627692338 Nonsignificant None 2 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:metal ion binding (GO:0046872) phospholipid-translocating ATPase 3.6.3.1 -- P-type ATPase R General function prediction only ; IPR008250 [P-type ATPase, A domain] ; IPR032630[P-type ATPase, C-terminal] ; IPR032631[P-type ATPase, N-terminal] -- -- Q3UWX7 Transcription elongation factor Tcea1 2017.2 1959.2 2045.3 1926.8 1912.5 1982.8 1.0342831624328 0.115645888727089 0.0486312157411234 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Cellular Component:nucleus (GO:0005634),Molecular Function:zinc ion binding (GO:0008270) transcription elongation factor S-II -- -- Transcription elongation factor TFIIS/Cofactor of enhancer-binding protein Sp1 K Transcription ; IPR001222 [Zinc finger, TFIIS-type] ; IPR003618[Transcription elongation factor S-II, central domain] ; IPR017923[Transcription factor IIS, N-terminal] -- -- Q9DBC3 Cap-specific mRNA (nucleoside-2-O-)-methyltransferase 1 Cmtr1 978.6 1038.4 985.8 968.8 1021.4 1007.5 1.00170130433332 0.948125709647253 0.00245237779526027 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:methyltransferase activity (GO:0008168),Biological Process:methylation (GO:0032259) cap1 methyltransferase 2.1.1.57 -- FtsJ-like RNA methyltransferase A RNA processing and modification ; IPR000467 [G-patch domain] ; IPR002877[Ribosomal RNA methyltransferase FtsJ domain] -- -- P54726 UV excision repair protein RAD23 homolog A Rad23a 511.7 530.8 763 765.7 751.8 698.1 0.814903412168261 0.176374516135101 -0.295299023327319 Nonsignificant None 4 Molecular Function:damaged DNA binding (GO:0003684),Molecular Function:protein binding (GO:0005515),Biological Process:nucleotide-excision repair (GO:0006289),Biological Process:proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161) UV excision repair protein RAD23 -- ko03420 Nucleotide excision repair ko04141 Protein processing in endoplasmic reticulum Nucleotide excision repair factor NEF2, RAD23 component L Replication, recombination and repair ; IPR000626 [Ubiquitin domain] ; IPR015360[XPC-binding domain] ; IPR015940[Ubiquitin-associated domain] -- -- Q9WUR2 Enoyl-CoA delta isomerase 2 Eci2 673.5 667.7 943.8 834.5 845.9 868.1 0.896605846576418 0.436873855139757 -0.157454187959945 Nonsignificant None 3 Molecular Function:fatty-acyl-CoA binding (GO:0000062),Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) peroxisomal 3,2-trans-enoyl-CoA isomerase 5.3.3.8 ko00071 Fatty acid degradation ko04146 Peroxisome Enoyl-CoA hydratase/isomerase I Lipid transport and metabolism ; IPR000582 [Acyl-CoA-binding protein, ACBP] ; IPR001753[Crotonase superfamily] -- -- A0A5E1 Insulin-like growth factor binding protein 7 Igfbp7 824.6 909.5 686.3 640.7 708.8 646 1.21292909045352 0.107967747454173 0.278495210935484 Nonsignificant None 4 Biological Process:regulation of cell growth (GO:0001558),Molecular Function:protein binding (GO:0005515),Molecular Function:insulin-like growth factor binding (GO:0005520),Cellular Component:extracellular region (GO:0005576) -- -- -- -- -- -- IPR000867 [Insulin-like growth factor-binding protein, IGFBP] ; IPR002350[Kazal domain] -- -- O35900 U6 snRNA-associated Sm-like protein LSm2 Lsm2 1821 1673.7 1793.9 1788.6 1822.9 1974 0.946844508101334 0.2453163785082 -0.0788005707879443 Nonsignificant None -- -- U6 snRNA-associated Sm-like protein LSm2 -- ko03018 RNA degradation ko03040 Spliceosome Predicted snRNP core protein A RNA processing and modification ; IPR001163 [LSM domain, eukaryotic/archaea-type] -- -- Q8R404 MICOS complex subunit MIC13 Micos13 484.6 446.9 498.1 540.6 553.7 591.1 0.848225940429572 0.0166787196470894 -0.237479490806064 Nonsignificant None -- -- -- -- -- -- -- -- IPR026769 [MICOS complex subunit Mic13] -- -- A2AEW9 GRIP1-associated protein 1 Gripap1 1004.4 1002.4 1133.6 1104.7 1059.3 1193.5 0.935338793745346 0.284623132752833 -0.0964390694329762 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q9D5T0 Outer mitochondrial transmembrane helix translocase Atad1 1223 1199.1 1502.6 1467.6 1414.1 1431.4 0.909948760752127 0.259812463212119 -0.136142785499169 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) AAA+-type ATPase O Posttranslational modification, protein turnover, chaperones ; IPR003959 [ATPase, AAA-type, core] -- -- P62774 Myotrophin Mtpn 3160.5 3520.8 3030.5 2798.1 2857.6 2664.4 1.16726962416317 0.04207064380548 0.22313784340546 Nonsignificant None -- -- -- -- -- Myotrophin and similar proteins K Transcription ; IPR020683 [Ankyrin repeat-containing domain] -- -- Q8BTS4 Nuclear pore complex protein Nup54 Nup54 1076 1038 894.9 833.6 840.9 861.7 1.1863812002208 0.100509073103094 0.246567641675317 Nonsignificant None -- -- nuclear pore complex protein Nup54 -- ko03013 RNA transport Nuclear pore complex, p54 component (sc Nup57) YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; IPR025712 [Nucleoporin Nup54, alpha-helical domain] -- -- Q9ERL9 Guanylate cyclase soluble subunit alpha-1 Gucy1a1 821 804.6 943 810 847.3 859 1.02078448515678 0.724463957001596 0.0296783069451649 Nonsignificant None 5 Molecular Function:guanylate cyclase activity (GO:0004383),Biological Process:cGMP biosynthetic process (GO:0006182),Biological Process:cyclic nucleotide biosynthetic process (GO:0009190),Molecular Function:phosphorus-oxygen lyase activity (GO:0016849),Biological Process:intracellular signal transduction (GO:0035556) guanylate cyclase soluble subunit alpha 4.6.1.2 ko00230 Purine metabolism ko04022 cGMP-PKG signaling pathway ko04270 Vascular smooth muscle contraction ko04540 Gap junction ko04611 Platelet activation ko04713 Circadian entrainment ko04730 Long-term depression ko04921 Oxytocin signaling pathway ko04924 Renin secretion ko04970 Salivary secretion Adenylate/guanylate kinase F Nucleotide transport and metabolism ; IPR001054 [Adenylyl cyclase class-3/4/guanylyl cyclase] ; IPR011645[Haem NO binding associated] -- -- Q9D6H6 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 Ndufb3 1815.2 1641.4 2186.2 2308.6 2179.5 2246.1 0.837931751358736 0.0920639825171664 -0.255095352139348 Nonsignificant None 3 Cellular Component:mitochondrion (GO:0005739),Cellular Component:mitochondrial respiratory chain complex I (GO:0005747),Biological Process:electron transport chain (GO:0022900) NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 3 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease NADH:ubiquinone oxidoreductase, NDUFB3/B12 subunit C Energy production and conversion ; IPR012576 [NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3] -- -- E9QAQ5 Glycogen synthase kinase-3 beta Gsk3b 712.3 686.4 685 706.6 718.7 721.5 0.970607415688466 0.102877256731363 -0.0430402121846896 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) glycogen synthase kinase 3 beta 2.7.11.26 ko01521 EGFR tyrosine kinase inhibitor resistance ko04012 ErbB signaling pathway ko04062 Chemokine signaling pathway ko04110 Cell cycle ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04310 Wnt signaling pathway ko04340 Hedgehog signaling pathway ko04360 Axon guidance ko04390 Hippo signaling pathway ko04510 Focal adhesion ko04550 Signaling pathways regulating pluripotency of stem cells ko04657 IL-17 signaling pathway ko04660 T cell receptor signaling pathway ko04662 B cell receptor signaling pathway ko04722 Neurotrophin signaling pathway ko04728 Dopaminergic synapse ko04910 Insulin signaling pathway ko04916 Melanogenesis ko04917 Prolactin signaling pathway ko04919 Thyroid hormone signaling pathway ko04931 Insulin resistance ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05160 Hepatitis C ko05162 Measles ko05164 Influenza A ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05210 Colorectal cancer ko05213 Endometrial cancer ko05215 Prostate cancer ko05217 Basal cell carcinoma ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer Glycogen synthase kinase-3 G Carbohydrate transport and metabolism ; IPR000719 [Protein kinase domain] -- -- B2RWW1 Microtubule-associated protein 1S Map1s 524.9 511.2 529.5 554 594.7 535.6 0.929525618951493 0.0967295144354795 -0.105433466617345 Nonsignificant None -- -- microtubule-associated protein 1 -- -- Microtubule-associated proteins Z Cytoskeleton ; -- -- -- Q8R2K3 Single-stranded DNA-binding protein Ssbp1 863.6 894.9 1054.8 1018.9 1051.8 936.5 0.935521415270019 0.398344286410356 -0.0961574159266674 Nonsignificant None 1 Molecular Function:single-stranded DNA binding (GO:0003697) single-strand DNA-binding protein -- ko03030 DNA replication ko03430 Mismatch repair ko03440 Homologous recombination Single-stranded DNA-binding protein L Replication, recombination and repair ; IPR000424 [Primosome PriB/single-strand DNA-binding] -- -- Q9EQI8 39S ribosomal protein L46, mitochondrial Mrpl46 1135.3 1069.2 1031.2 893.5 965.8 1022.5 1.12280519119994 0.0704501471331797 0.167107639163559 Nonsignificant None -- -- large subunit ribosomal protein L46 -- -- Mitochondrial ribosomal protein L17 J Translation, ribosomal structure and biogenesis ; IPR021757 [Ribosomal protein L46] -- -- A2AWP8 Rho guanine nucleotide exchange factor 10-like protein Arhgef10l 1049.8 1064.5 1026.2 948.8 1060.4 957.8 1.05847657566566 0.197809730115279 0.0819893425198731 Nonsignificant None 2 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Biological Process:regulation of Rho protein signal transduction (GO:0035023) Rho guanine nucleotide exchange factor 10 -- -- Predicted guanine nucleotide exchange factor T Signal transduction mechanisms ; IPR000219 [Dbl homology (DH) domain] -- -- Q8BQ46 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor Taf15 686.7 786.7 725.1 735.5 772.1 646.3 1.02070662519151 0.769328574451222 0.0295682617088607 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:zinc ion binding (GO:0008270) transcription initiation factor TFIID subunit 15 -- ko03022 Basal transcription factors ko05202 Transcriptional misregulation in cancer Conserved Zn-finger protein R General function prediction only ; IPR000504 [RNA recognition motif domain] ; IPR001876[Zinc finger, RanBP2-type] -- -- Q91VT0 DNA polymerase Pold1 1072.1 1085.6 1138 1201.4 1252.7 1195.5 0.903030469092503 0.0121123723901867 -0.147153428480164 Nonsignificant None 3 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:DNA binding (GO:0003677),Molecular Function:3'-5' exonuclease activity (GO:0008408) DNA polymerase delta subunit 1 2.7.7.7 ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways ko03030 DNA replication ko03410 Base excision repair ko03420 Nucleotide excision repair ko03430 Mismatch repair ko03440 Homologous recombination ko05166 HTLV-I infection DNA polymerase delta, catalytic subunit L Replication, recombination and repair ; IPR006133 [DNA-directed DNA polymerase, family B, exonuclease domain] ; IPR006134[DNA-directed DNA polymerase, family B, multifunctional domain] ; IPR025687[C4-type zinc-finger of DNA polymerase delta] -- -- Q8BVQ5 Protein phosphatase methylesterase 1 Ppme1 1420.6 1395.5 1551.3 1486.2 1485.3 1399.6 0.999153531147766 0.983539548283018 -0.00122171355960065 Nonsignificant None -- -- protein phosphatase methylesterase 1 3.1.1.89 -- Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold R General function prediction only ; IPR000073 [Alpha/beta hydrolase fold-1] -- -- Q9JL35 High mobility group nucleosome-binding domain-containing protein 5 Hmgn5 1525.3 1490.5 2212.6 2344.4 2489.9 2504.1 0.712471383407827 0.0430977279324943 -0.489096025767835 Nonsignificant None 3 Cellular Component:chromatin (GO:0000785),Cellular Component:nucleus (GO:0005634),Molecular Function:nucleosomal DNA binding (GO:0031492) high-mobility group nucleosome-binding domain-containing protein 5 -- -- -- -- -- IPR000079 [High mobility group protein HMGN] -- -- Q99K70 Ras-related GTP-binding protein C Rragc 1048.3 1063.8 1068.5 1111.9 1070.7 1144.5 0.955967659523309 0.0927592797541672 -0.0649662823660107 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) Ras-related GTP-binding protein C/D -- ko04140 Autophagy - animal ko04150 mTOR signaling pathway Predicted small GTPase involved in nuclear protein import U Intracellular trafficking, secretion, and vesicular transport ; IPR006762 [Gtr1/RagA G protein] -- -- Q5EBG6 Heat shock protein beta-6 Hspb6 1593.4 1758.5 1202.9 1116.6 1123.3 1001.5 1.40519528598754 0.0610476806139273 0.490770641868046 Nonsignificant None 1 Molecular Function:structural constituent of eye lens (GO:0005212) heat shock protein beta-6 -- -- Alpha crystallins O Posttranslational modification, protein turnover, chaperones ; IPR002068 [Alpha crystallin/Hsp20 domain] ; IPR003090[Alpha-crystallin, N-terminal] -- -- P97822 Acidic leucine-rich nuclear phosphoprotein 32 family member E Anp32e 811.1 762.7 827.6 734.7 769.1 766.4 1.05779226499868 0.122479883838676 0.0810563309656566 Nonsignificant None -- -- acidic leucine-rich nuclear phosphoprotein 32 family member E -- -- Leucine-rich acidic nuclear protein DR Cell cycle control, cell division, chromosome partitioning ; General function prediction only ; -- -- -- Q3TBW2 39S ribosomal protein L10, mitochondrial Mrpl10 514.1 451.4 606.4 487.4 503.8 569.9 1.00691819870604 0.947724102957814 0.0099464846210612 Nonsignificant None -- -- large subunit ribosomal protein L10 -- ko03010 Ribosome Mitochondrial ribosomal protein L10 J Translation, ribosomal structure and biogenesis ; -- -- -- Q8BYK6 YTH domain-containing family protein 3 Ythdf3 2314.8 2295.8 2509.3 1971.8 2038.6 2091.9 1.16675679661767 0.0114165220986735 0.222503871345807 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) YTH domain-containing family protein -- -- Uncharacterized high-glucose-regulated protein R General function prediction only ; IPR007275 [YTH domain] -- -- Q4V9X1 Ribosome biogenesis protein WDR12 Wdr12 1261 1178 1312.8 1150.9 1148.9 1218.6 1.06633697135061 0.162130446127496 0.0926634137773222 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) ribosome biogenesis protein YTM1 -- -- Microtubule binding protein YTM1 (contains WD40 repeats) Z Cytoskeleton ; IPR001680 [WD40 repeat] ; IPR012972[NLE] -- -- Q8CDG8 Leucine zipper transcription factor-like protein 1 Lztfl1 1503.4 1476.1 1468.8 1464.2 1482.7 1418.8 1.01892021897977 0.273468907221558 0.0270410935172229 Nonsignificant None -- -- leucine zipper transcription factor-like protein 1 -- -- -- -- -- -- -- -- Q9CQ75 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 Ndufa2 1394.2 1433.1 1757.1 2253 2037.1 2150.6 0.711785985995311 0.0091107253683728 -0.490484566274136 Nonsignificant None -- -- NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 2 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease NADH:ubiquinone oxidoreductase NDUFA2/B8 subunit C Energy production and conversion ; IPR007741 [Ribosomal protein/NADH dehydrogenase domain] -- -- P48410 ATP-binding cassette sub-family D member 1 Abcd1 544.7 486.6 441.8 464.2 492.2 503.6 1.00897260273973 0.898066106734295 0.0128870005808789 Nonsignificant None 5 Molecular Function:ATP binding (GO:0005524),Biological Process:transport (GO:0006810),Cellular Component:integral component of membrane (GO:0016021),Molecular Function:ATPase activity (GO:0016887),Biological Process:transmembrane transport (GO:0055085) ATP-binding cassette, subfamily D (ALD), member 1 -- ko02010 ABC transporters ko04146 Peroxisome Peroxisomal long-chain acyl-CoA transporter, ABC superfamily I Lipid transport and metabolism ; IPR003439 [ABC transporter-like] ; IPR011527[ABC transporter type 1, transmembrane domain] -- -- Q3UGR1 Uncharacterized protein (Fragment) Safb2 554.6 600.3 546.2 474 438.1 454.8 1.24449484234399 0.00486481060748133 0.315560251258951 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- Hsp27-ERE-TATA-binding protein/Scaffold attachment factor (SAF-B) K Transcription ; IPR000504 [RNA recognition motif domain] ; IPR003034[SAP domain] -- -- Q9CQ52 Chymotrypsin-like elastase family member 3B Cela3b 1107.7 910 1629 672.3 968 635.7 1.60224077328647 0.128329695490062 0.68009096193232 Nonsignificant None 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) pancreatic endopeptidase E 3.4.21.70 ko04972 Pancreatic secretion ko04974 Protein digestion and absorption Trypsin E Amino acid transport and metabolism ; IPR001254 [Serine proteases, trypsin domain] -- -- E9PZJ8 Activating signal cointegrator 1 complex subunit 3 Ascc3 1287.2 1295.7 1254.8 1342.9 1421.8 1350.2 0.932635057960096 0.030221957270953 -0.100615432961491 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) activating signal cointegrator complex subunit 3 3.6.4.12 -- DNA/RNA helicase MER3/SLH1, DEAD-box superfamily A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR004179[Sec63 domain] ; IPR011545[DEAD/DEAH box helicase domain] -- -- Q4FK74 ATP synthase F1 subunit delta Atp5d 1366.9 1364.2 1644.7 1673.6 1615.9 1741.5 0.869767441860465 0.094050510339216 -0.201298389701824 Nonsignificant None 1 Biological Process:ATP synthesis coupled proton transport (GO:0015986) F-type H+-transporting ATPase subunit delta -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Mitochondrial F1F0-ATP synthase, subunit delta/ATP16 C Energy production and conversion ; IPR020546 [ATP synthase, F1 complex, delta/epsilon subunit, N-terminal] -- -- P61759 Prefoldin subunit 3 Vbp1 1769.5 1834 2004.6 1720.8 1872.8 1704.5 1.0585115418735 0.306696503211798 0.0820370003921541 Nonsignificant None -- -- -- -- -- Molecular chaperone Prefoldin, subunit 3 O Posttranslational modification, protein turnover, chaperones ; IPR004127 [Prefoldin alpha-like] -- -- O08997 Copper transport protein ATOX1 Atox1 1920.7 1910.6 2096.1 1993.8 2022.6 2209.4 0.952070416653282 0.333527155832492 -0.0708598133714521 Nonsignificant None 2 Biological Process:metal ion transport (GO:0030001),Molecular Function:metal ion binding (GO:0046872) copper chaperone -- ko04978 Mineral absorption Copper chaperone P Inorganic ion transport and metabolism ; IPR006121 [Heavy metal-associated domain, HMA] -- -- Q9D1J1 Adaptin ear-binding coat-associated protein 2 Necap2 1119.9 1135.1 738.3 708.3 737.5 734.6 1.37282150064208 0.171478804712907 0.457144053103655 Nonsignificant None 2 Biological Process:endocytosis (GO:0006897),Cellular Component:membrane (GO:0016020) adaptin ear-binding coat-associated protein 1/2 -- -- Uncharacterized conserved protein S Function unknown ; IPR012466 [NECAP, PHear domain] -- -- Q9D9V3 Ethylmalonyl-CoA decarboxylase Echdc1 878.6 793 1055.9 1084 1106.2 1126.2 0.822427933904234 0.123348409065888 -0.282038828141682 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) -- -- ko00640 Propanoate metabolism Enoyl-CoA hydratase I Lipid transport and metabolism ; IPR001753 [Crotonase superfamily] -- -- Q8CDM8 FHF complex subunit HOOK interacting protein 2A Fhip2a 470.4 491.6 474 515.1 521.1 515.1 0.925675240121189 0.00495300171543387 -0.111421961494132 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019384 [Retinoic acid induced 16-like protein] -- -- Q91VF0 L-Fucosyltransferase (Fragment) FUT2 1403.1 1338.3 1451.8 1094.6 1128.7 1084.4 1.26770867974726 0.0011427571230944 0.342223251335939 Nonsignificant None 3 Biological Process:carbohydrate metabolic process (GO:0005975),Molecular Function:galactoside 2-alpha-L-fucosyltransferase activity (GO:0008107),Cellular Component:membrane (GO:0016020) galactoside 2-L-fucosyltransferase 1/2 2.4.1.69 ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series ko00603 Glycosphingolipid biosynthesis - globo and isoglobo series ko01100 Metabolic pathways -- -- -- IPR002516 [Glycosyl transferase, family 11] -- -- A0A0R4J0B5 RUS family member 1 Rusf1 336.7 354.9 322.6 266.2 263.5 293 1.2327701470767 0.00858050684562399 0.301903830896325 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR006968 [Root UVB sensitive family] -- -- Q8R1G2 Carboxymethylenebutenolidase homolog Cmbl 1938.8 1834.7 2710.7 2402.2 2071.1 2682 0.906209383254371 0.532540695534969 -0.142083665717297 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) carboxymethylenebutenolidase 3.1.1.45 ko01100 Metabolic pathways Predicted hydrolase related to dienelactone hydrolase R General function prediction only ; IPR002925 [Dienelactone hydrolase] -- -- E9QAT4 Protein transport protein Sec16A Sec16a 1017.3 1029.9 1035.3 1170.7 1106.4 1111 0.909801953897465 0.00888244847118513 -0.136375561911834 Nonsignificant None -- -- COPII coat assembly protein SEC16 -- -- Regucalcin gene promoter region-related protein (RGPR) K Transcription ; IPR024298 [Ancestral coatomer element 1, Sec16/Sec31] ; IPR024340[Sec16, central conserved domain] -- -- P11672 Neutrophil gelatinase-associated lipocalin Lcn2 1340.9 2213.2 1057.8 548.3 619.5 545.2 2.6922942206655 0.108046781658981 1.42883607989644 Nonsignificant None -- -- lipocalin 2 -- ko04657 IL-17 signaling pathway -- -- -- IPR000566 [Lipocalin/cytosolic fatty-acid binding domain] -- -- A0A0R4J077 Pentaxin Mptx1 923.5 836.9 858.6 1762.3 1709.6 1480.8 0.528802471379248 0.000995192064361908 -0.919199175533715 Significant down -- -- -- -- -- -- -- -- IPR001759 [Pentraxin-related] -- -- B8JK39 Integrin alpha-9 Itga9 826.3 820.6 933.6 969.2 958.8 1002.6 0.8805364089265 0.040417777897621 -0.183545436212216 Nonsignificant None -- -- integrin alpha 9 -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04514 Cell adhesion molecules (CAMs) ko04810 Regulation of actin cytoskeleton ko05165 Human papillomavirus infection ko05410 Hypertrophic cardiomyopathy (HCM) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05414 Dilated cardiomyopathy (DCM) Vitronectin receptor, alpha subunit W Extracellular structures ; IPR013517 [FG-GAP repeat] ; IPR013649[Integrin alpha-2] -- -- O54890 Integrin beta-3 Itgb3 2170.8 2292.8 2353.8 2418.7 2568.1 2375.4 0.9260003803211 0.0840682138734284 -0.110915308867022 Nonsignificant None -- -- integrin beta 3 -- ko04015 Rap1 signaling pathway ko04145 Phagosome ko04151 PI3K-Akt signaling pathway ko04380 Osteoclast differentiation ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04611 Platelet activation ko04640 Hematopoietic cell lineage ko04810 Regulation of actin cytoskeleton ko04919 Thyroid hormone signaling pathway ko05165 Human papillomavirus infection ko05205 Proteoglycans in cancer ko05206 MicroRNAs in cancer ko05410 Hypertrophic cardiomyopathy (HCM) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05414 Dilated cardiomyopathy (DCM) ko05418 Fluid shear stress and atherosclerosis Integrin beta subunit (N-terminal portion of extracellular region) TW Signal transduction mechanisms ; Extracellular structures ; IPR002369 [Integrin beta subunit, VWA domain] ; IPR012896[Integrin beta subunit, tail] ; IPR013111[EGF-like domain, extracellular] ; IPR014836[Integrin beta subunit, cytoplasmic domain] ; IPR033760[Integrin beta N-terminal] -- -- Q91VT4 3-oxoacyl-[acyl-carrier-protein] reductase Cbr4 1092.5 984.5 1086.4 1273.9 1223.4 1246 0.845083215344749 0.00701438038356367 -0.242834684316061 Nonsignificant None -- -- carbonyl reductase 4 1.1.1.- -- Mitochondrial/plastidial beta-ketoacyl-ACP reductase I Lipid transport and metabolism ; -- -- -- G3UYG6 GRB10-interacting GYF protein 2 Gigyf2 1519.4 1551.8 1173.5 1133.4 1227.7 1130.1 1.21582836846929 0.115347917389629 0.281939586154551 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) PERQ amino acid-rich with GYF domain-containing protein -- -- GYF domain containing proteins R General function prediction only ; IPR003169 [GYF domain] -- -- Q01279 Epidermal growth factor receptor Egfr 1049.3 1076.9 964.1 980.4 1043.1 1000.9 1.0217894458405 0.600108719992052 0.0310979391941397 Nonsignificant None 6 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:transmembrane receptor protein tyrosine kinase activity (GO:0004714),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468),Biological Process:transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169),Cellular Component:membrane (GO:0016020) epidermal growth factor receptor 2.7.10.1 ko01521 EGFR tyrosine kinase inhibitor resistance ko01522 Endocrine resistance ko04010 MAPK signaling pathway ko04012 ErbB signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04020 Calcium signaling pathway ko04060 Cytokine-cytokine receptor interaction ko04066 HIF-1 signaling pathway ko04068 FoxO signaling pathway ko04072 Phospholipase D signaling pathway ko04144 Endocytosis ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04520 Adherens junction ko04540 Gap junction ko04630 Jak-STAT signaling pathway ko04810 Regulation of actin cytoskeleton ko04912 GnRH signaling pathway ko04915 Estrogen signaling pathway ko04921 Oxytocin signaling pathway ko04926 Relaxin signaling pathway ko05160 Hepatitis C ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05206 MicroRNAs in cancer ko05212 Pancreatic cancer ko05213 Endometrial cancer ko05214 Glioma ko05215 Prostate cancer ko05218 Melanoma ko05219 Bladder cancer ko05223 Non-small cell lung cancer ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer ko05230 Central carbon metabolism in cancer ko05231 Choline metabolism in cancer Epidermal growth factor receptor EGFR and related tyrosine kinases T Signal transduction mechanisms ; IPR000494 [Receptor L-domain] ; IPR001245[Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR006211[Furin-like cysteine-rich domain] ; IPR032778[Growth factor receptor domain 4] -- -- O70378 ER membrane protein complex subunit 8 Emc8 2045.1 2150.4 1835.1 1899.9 1883.8 1832.8 1.07372919077717 0.21932158899741 0.102630171733019 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein encoded by sequence overlapping the COX4 gene R General function prediction only ; IPR005366 [ER membrane protein complex subunit 8/9] -- -- Q3UDG5 Nsp1_C domain-containing protein Nup62 1287.1 1251.1 1384.8 1270 1271.3 1332.1 1.01280528734445 0.731306373574386 0.0183568414801056 Nonsignificant None -- -- nuclear pore complex protein Nup62 -- ko03013 RNA transport Nuclear porin Y Nuclear structure ; IPR007758 [Nucleoporin, NSP1-like, C-terminal] -- -- Q9D0M5 Dynein light chain 2, cytoplasmic Dynll2 1144.6 964.9 949.8 933.8 858 1124.7 1.04896279787416 0.662130471190854 0.0689635127348315 Nonsignificant None 2 Biological Process:microtubule-based process (GO:0007017),Cellular Component:dynein complex (GO:0030286) dynein light chain LC8-type -- ko04962 Vasopressin-regulated water reabsorption Dynein light chain type 1 Z Cytoskeleton ; IPR001372 [Dynein light chain, type 1/2] -- -- Q62084 Protein phosphatase 1 regulatory subunit 14B Ppp1r14b 523.9 581.6 477.8 466.1 450.4 442.7 1.16487639788111 0.072382954851764 0.220176882240766 Nonsignificant None 2 Cellular Component:cytoplasm (GO:0005737),Biological Process:regulation of phosphorylation (GO:0042325) protein phosphatase 1 regulatory subunit 14B -- -- -- -- -- IPR008025 [PKC-activated phosphatase-1 inhibitor] -- -- A0A0N4SVU1 Predicted gene 7298 Gm7298 149.2 206.8 216 163.6 202.6 114.1 1.19092234020404 0.40745570485503 0.252079338428339 Nonsignificant None 3 Molecular Function:endopeptidase inhibitor activity (GO:0004866),Cellular Component:extracellular region (GO:0005576),Cellular Component:extracellular space (GO:0005615) -- -- -- Alpha-macroglobulin O Posttranslational modification, protein turnover, chaperones ; IPR001599 [Alpha-2-macroglobulin] ; IPR002890[Alpha-2-macroglobulin, N-terminal] ; IPR009048[Alpha-macroglobulin, receptor-binding] ; IPR011625[Alpha-2-macroglobulin, N-terminal 2] ; IPR011626[Alpha-macroglobulin complement component] ; IPR019565[Alpha-2-macroglobulin, thiol-ester bond-forming] -- -- A0JNY3 Gephyrin Gphn 1325.5 1351.8 1636.4 1747.3 1737 1643.2 0.841287176986836 0.0609503434077924 -0.249329740193302 Nonsignificant None 1 Biological Process:molybdopterin cofactor biosynthetic process (GO:0032324) -- -- ko00790 Folate biosynthesis ko01100 Metabolic pathways ko04727 GABAergic synapse Molybdopterin biosynthesis protein H Coenzyme transport and metabolism ; IPR001453 [MoaB/Mog domain] ; IPR005110[MoeA, N-terminal and linker domain] ; IPR005111[MoeA, C-terminal, domain IV] -- -- Q8CE74 Uncharacterized protein (Fragment) Akt2 478.5 462.7 486 468.5 506.6 515.1 0.957723795463696 0.256796691943816 -0.0623184476621362 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) RAC serine/threonine-protein kinase 2.7.11.1 ko01521 EGFR tyrosine kinase inhibitor resistance ko01522 Endocrine resistance ko01524 Platinum drug resistance ko04010 MAPK signaling pathway ko04012 ErbB signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04062 Chemokine signaling pathway ko04066 HIF-1 signaling pathway ko04068 FoxO signaling pathway ko04071 Sphingolipid signaling pathway ko04072 Phospholipase D signaling pathway ko04140 Autophagy - animal ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04152 AMPK signaling pathway ko04210 Apoptosis ko04211 Longevity regulating pathway ko04213 Longevity regulating pathway - multiple species ko04218 Cellular senescence ko04261 Adrenergic signaling in cardiomyocytes ko04370 VEGF signaling pathway ko04371 Apelin signaling pathway ko04380 Osteoclast differentiation ko04510 Focal adhesion ko04550 Signaling pathways regulating pluripotency of stem cells ko04611 Platelet activation ko04620 Toll-like receptor signaling pathway ko04630 Jak-STAT signaling pathway ko04660 T cell receptor signaling pathway ko04662 B cell receptor signaling pathway ko04664 Fc epsilon RI signaling pathway ko04666 Fc gamma R-mediated phagocytosis ko04668 TNF signaling pathway ko04722 Neurotrophin signaling pathway ko04725 Cholinergic synapse ko04728 Dopaminergic synapse ko04910 Insulin signaling pathway ko04914 Progesterone-mediated oocyte maturation ko04915 Estrogen signaling pathway ko04917 Prolactin signaling pathway ko04919 Thyroid hormone signaling pathway ko04920 Adipocytokine signaling pathway ko04922 Glucagon signaling pathway ko04923 Regulation of lipolysis in adipocytes ko04926 Relaxin signaling pathway ko04931 Insulin resistance ko04932 Non-alcoholic fatty liver disease (NAFLD) ko04933 AGE-RAGE signaling pathway in diabetic complications ko04973 Carbohydrate digestion and absorption ko05142 Chagas disease (American trypanosomiasis) ko05145 Toxoplasmosis ko05152 Tuberculosis ko05160 Hepatitis C ko05161 Hepatitis B ko05162 Measles ko05164 Influenza A ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05210 Colorectal cancer ko05211 Renal cell carcinoma ko05212 Pancreatic cancer ko05213 Endometrial cancer ko05214 Glioma ko05215 Prostate cancer ko05218 Melanoma ko05220 Chronic myeloid leukemia ko05221 Acute myeloid leukemia ko05222 Small cell lung cancer ko05223 Non-small cell lung cancer ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer ko05230 Central carbon metabolism in cancer ko05231 Choline metabolism in cancer ko05418 Fluid shear stress and atherosclerosis Serine/threonine protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR017892[Protein kinase, C-terminal] -- -- I1E4X5 VPS35 endosomal protein-sorting factor-like Vps35l 1004.6 978.3 1017.7 924.4 963.1 1006.5 1.03683483068417 0.249413260280925 0.0521860890096422 Nonsignificant None -- -- -- -- -- Predicted membrane protein (associated with esophageal cancer in humans) S Function unknown ; -- -- -- Q05186 Reticulocalbin-1 Rcn1 2205.6 2249.6 3022.3 2458.2 2405.5 2328.2 1.03971134192633 0.75510625827521 0.0561830443514281 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) -- -- -- Reticulocalbin, calumenin, DNA supercoiling factor, and related Ca2+-binding proteins of the CREC family (EF-Hand protein superfamily) TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR002048 [EF-hand domain] -- -- A0A158SIT8 Proline-, glutamic acid- and leucine-rich protein 1 Pelp1 1131.6 1149.8 1263.9 1072 1107 1098.2 1.08180764066886 0.104574767602582 0.1134439922104 Nonsignificant None -- -- proline-, glutamic acid- and leucine-rich protein 1 -- -- -- -- -- IPR012583 [Pre-rRNA-processing protein RIX1, N-terminal] ; IPR012980[Uncharacterised domain NUC202] -- -- Q8QZV8 Histone acetyltransferase (Fragment) 189.5 161.6 154.4 176.1 174.1 165.5 0.98022105875509 0.776334689746836 -0.0288209534088403 Nonsignificant None 8 Cellular Component:histone acetyltransferase complex (GO:0000123),Molecular Function:transcription cofactor activity (GO:0003712),Molecular Function:transcription coactivator activity (GO:0003713),Molecular Function:histone acetyltransferase activity (GO:0004402),Molecular Function:protein binding (GO:0005515),Cellular Component:nucleus (GO:0005634),Molecular Function:zinc ion binding (GO:0008270),Biological Process:histone acetylation (GO:0016573) E1A/CREB-binding protein 2.3.1.48 ko04024 cAMP signaling pathway ko04066 HIF-1 signaling pathway ko04068 FoxO signaling pathway ko04110 Cell cycle ko04310 Wnt signaling pathway ko04330 Notch signaling pathway ko04350 TGF-beta signaling pathway ko04520 Adherens junction ko04630 Jak-STAT signaling pathway ko04720 Long-term potentiation ko04916 Melanogenesis ko04919 Thyroid hormone signaling pathway ko04922 Glucagon signaling pathway ko05016 Huntington's disease ko05152 Tuberculosis ko05161 Hepatitis B ko05164 Influenza A ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05206 MicroRNAs in cancer ko05211 Renal cell carcinoma ko05215 Prostate cancer CREB binding protein/P300 and related TAZ Zn-finger proteins K Transcription ; IPR000197 [Zinc finger, TAZ-type] ; IPR000433[Zinc finger, ZZ-type] ; IPR001487[Bromodomain] ; IPR003101[Coactivator CBP, KIX domain] ; IPR010303[CREB-binding protein/p300, atypical RING domain] ; IPR013178[Histone acetyltransferase Rtt109/CBP] ; IPR014744[Nuclear receptor coactivator, CREB-bp-like, interlocking] -- -- Q542I8 Integrin beta Itgb2 1428.1 1878.1 1406.5 1080.3 1121.9 1022.1 1.46161957634215 0.0338041748082337 0.547567862082011 Nonsignificant None -- -- integrin beta 2 -- ko04015 Rap1 signaling pathway ko04145 Phagosome ko04390 Hippo signaling pathway ko04514 Cell adhesion molecules (CAMs) ko04610 Complement and coagulation cascades ko04650 Natural killer cell mediated cytotoxicity ko04670 Leukocyte transendothelial migration ko04810 Regulation of actin cytoskeleton ko05133 Pertussis ko05134 Legionellosis ko05140 Leishmaniasis ko05144 Malaria ko05146 Amoebiasis ko05150 Staphylococcus aureus infection ko05152 Tuberculosis ko05166 HTLV-I infection ko05323 Rheumatoid arthritis ko05416 Viral myocarditis Integrin beta subunit (N-terminal portion of extracellular region) TW Signal transduction mechanisms ; Extracellular structures ; IPR002369 [Integrin beta subunit, VWA domain] ; IPR012896[Integrin beta subunit, tail] ; IPR014836[Integrin beta subunit, cytoplasmic domain] ; IPR033760[Integrin beta N-terminal] -- -- Q8BP44 Protein kinase domain-containing protein Map2k6 654.1 642.7 863.8 1075 1000.4 1033.2 0.695039567651033 0.0135787220964928 -0.5248329840598 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) mitogen-activated protein kinase kinase 6 2.7.12.2 ko04010 MAPK signaling pathway ko04015 Rap1 signaling pathway ko04218 Cellular senescence ko04380 Osteoclast differentiation ko04620 Toll-like receptor signaling pathway ko04664 Fc epsilon RI signaling pathway ko04668 TNF signaling pathway ko04750 Inflammatory mediator regulation of TRP channels ko04912 GnRH signaling pathway ko05014 Amyotrophic lateral sclerosis (ALS) ko05145 Toxoplasmosis ko05164 Influenza A ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05169 Epstein-Barr virus infection ko05418 Fluid shear stress and atherosclerosis Mitogen-activated protein kinase (MAPK) kinase MKK3/MKK6 T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q9CZT8 Ras-related protein Rab-3B Rab3b 116.5 107.5 115.9 141.7 113.9 143.5 0.851666249060386 0.120024120409724 -0.2316399169696 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-3B -- -- GTPase Rab3, small G protein superfamily U Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- Q3U1S0 Importin N-terminal domain-containing protein Tnpo2 406.5 376.3 411.3 360.6 365.8 435.5 1.0277132283329 0.70634010649086 0.0394377530735101 Nonsignificant None 2 Biological Process:intracellular protein transport (GO:0006886),Molecular Function:Ran GTPase binding (GO:0008536) transportin-2 -- -- Nuclear transport receptor Karyopherin-beta2/Transportin (importin beta superfamily) YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; IPR001494 [Importin-beta, N-terminal domain] -- -- Q3TAF0 Tr-type G domain-containing protein Eefsec 986.6 1025.4 983.1 1011.3 1020.7 1017.1 0.982289856023089 0.262927338456714 -0.0257792942341233 Nonsignificant None -- -- selenocysteine-specific elongation factor -- -- Selenocysteine-specific elongation factor J Translation, ribosomal structure and biogenesis ; -- -- -- Q8R1S0 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial Coq6 1143.7 1076.6 1164.7 1171.7 1131.8 1178.1 0.972254136029412 0.347246401230531 -0.0405946279006181 Nonsignificant None 1 Molecular Function:FAD binding (GO:0071949) ubiquinone biosynthesis monooxygenase Coq6 1.14.13.- ko00130 Ubiquinone and other terpenoid-quinone biosynthesis ko01100 Metabolic pathways Monooxygenase involved in coenzyme Q (ubiquinone) biosynthesis HC Coenzyme transport and metabolism ; Energy production and conversion ; IPR002938 [FAD-binding domain] -- -- P47199 Quinone oxidoreductase Cryz 1359.1 1322.3 1390.5 1553.5 1508.8 1581.7 0.876808785529716 0.0027549385383924 -0.189665840867376 Nonsignificant None 1 Biological Process:oxidation-reduction process (GO:0055114) NADPH2:quinone reductase 1.6.5.5 -- Zinc-binding oxidoreductase CR Energy production and conversion ; General function prediction only ; IPR013149 [Alcohol dehydrogenase, C-terminal] ; IPR013154[Alcohol dehydrogenase, N-terminal] -- -- Q91WC0 Actin-histidine N-methyltransferase Setd3 1742.7 1795.5 1555.9 1549 1677 1605.9 1.05426436805397 0.344303404597802 0.0762366835368613 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) histone-lysine N-methyltransferase SETD3 2.1.1.43 ko00310 Lysine degradation N-methyltransferase R General function prediction only ; IPR001214 [SET domain] ; IPR015353[Rubisco LSMT, substrate-binding domain] -- -- Q3UC82 DNA ligase Lig3 1885 1870.4 1774.4 1716.6 1730.7 1820.4 1.04975606051977 0.139962863532608 0.0700541172575502 Nonsignificant None 6 Molecular Function:DNA binding (GO:0003677),Molecular Function:DNA ligase (ATP) activity (GO:0003910),Molecular Function:ATP binding (GO:0005524),Biological Process:DNA repair (GO:0006281),Biological Process:DNA recombination (GO:0006310),Molecular Function:zinc ion binding (GO:0008270) DNA ligase 3 6.5.1.1 ko03410 Base excision repair ATP-dependent DNA ligase III L Replication, recombination and repair ; IPR001510 [Zinc finger, PARP-type] ; IPR012308[DNA ligase, ATP-dependent, N-terminal] ; IPR012309[DNA ligase, ATP-dependent, C-terminal] ; IPR012310[DNA ligase, ATP-dependent, central] ; IPR031916[DNA ligase 3, BRCT domain] -- -- A2RRJ4 Exportin 5 Xpo5 1152.8 1515.1 1018.5 778.1 872.9 744.5 1.53888541014402 0.048386392074375 0.621885808422561 Significant up -- -- exportin-5 -- ko03013 RNA transport Nuclear transport receptor CRM1/MSN5 (importin beta superfamily) YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; IPR013598 [Exportin-1/Importin-beta-like] -- -- Q9D1R9 60S ribosomal protein L34 Rpl34 5465.3 5285.4 4639.2 3822.2 3712.8 3839.3 1.35304150585091 0.0307574404233842 0.436206096052678 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L34e -- ko03010 Ribosome 60s ribosomal protein L34 J Translation, ribosomal structure and biogenesis ; IPR008195 [Ribosomal protein L34Ae] -- -- Q9CSC2 PX domain-containing protein (Fragment) Snx3 1273.7 1477.4 1441.1 1498.4 1530.5 1416.2 0.943105891880948 0.302966831205068 -0.084508329167578 Nonsignificant None 1 Molecular Function:phosphatidylinositol binding (GO:0035091) sorting nexin-3/12 -- ko04144 Endocytosis Sorting nexin SNX11 U Intracellular trafficking, secretion, and vesicular transport ; IPR001683 [Phox homologous domain] -- -- F8WJ64 Acyl carrier protein (Fragment) Ndufab1 3068.9 3000.5 3228.1 3404 3344.4 3687.2 0.890940626317605 0.038969516891803 -0.166598803399742 Nonsignificant None -- -- NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Acyl carrier protein/NADH-ubiquinone oxidoreductase, NDUFAB1/SDAP subunit CIQ Energy production and conversion ; Lipid transport and metabolism ; Secondary metabolites biosynthesis, transport and catabolism ; IPR009081 [Phosphopantetheine binding ACP domain] -- -- Q8K284 General transcription factor 3C polypeptide 1 Gtf3c1 572.4 543.6 484.7 481.5 535.6 540.6 1.0276048019516 0.67742280330181 0.0392855370169633 Nonsignificant None -- -- general transcription factor 3C polypeptide 1 -- -- Transcription factor IIIC box B binding (alpha) subunit K Transcription ; IPR007309 [B-block binding subunit of TFIIIC] -- -- B2RXQ8 WD repeat domain containing 82 Wdr82 1561.5 1650.8 1819.4 1792.1 1772.9 1771.1 0.942954592305242 0.311358784684929 -0.084739794860071 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) COMPASS component SWD2 -- ko03015 mRNA surveillance pathway Histone H3 (Lys4) methyltransferase complex and RNA cleavage factor II complex, subunit SWD2 ABO RNA processing and modification ; Chromatin structure and dynamics ; Posttranslational modification, protein turnover, chaperones ; IPR001680 [WD40 repeat] -- -- Q3UU20 Uncharacterized protein Hid1 1690.1 1603.6 1452.9 2112 2121.9 2191.5 0.738724437389112 0.00161233827088393 -0.436891791343425 Nonsignificant None -- -- -- -- -- Proteins containing regions of low-complexity R General function prediction only ; -- -- -- Q3TM87 Ubiquitin-like modifier-activating enzyme ATG7 Atg7 1094.5 1137.7 1091 1119.2 1139 1175 0.967959920773622 0.173758349792476 -0.0469807821996915 Nonsignificant None 1 Molecular Function:small protein activating enzyme activity (GO:0008641) ubiquitin-like modifier-activating enzyme ATG7 -- ko04136 Autophagy - other ko04140 Autophagy - animal ko04216 Ferroptosis Ubiquitin activating E1 enzyme-like protein H Coenzyme transport and metabolism ; IPR000594 [THIF-type NAD/FAD binding fold] ; IPR032197[Ubiquitin-like modifier-activating enzyme Atg7, N-terminal] -- -- A2A9P6 Cyclin-dependent kinase 11B Cdk11b 1937.4 1882 1950.8 1807.7 1846.5 1725 1.07268738845925 0.0349795235539409 0.101229695077908 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) cell division cycle 2-like 2.7.11.22 -- Protein kinase PITSLRE and related kinases R General function prediction only ; IPR000719 [Protein kinase domain] -- -- E9PVA6 ARF GTPase-activating protein GIT2 Git2 447.7 476.2 500.3 495.2 518.7 483.9 0.950861263186006 0.251868403896431 -0.0726932369926659 Nonsignificant None 1 Molecular Function:GTPase activator activity (GO:0005096) G protein-coupled receptor kinase interactor 2 -- ko04144 Endocytosis GTPase-activating proteins of the GIT family T Signal transduction mechanisms ; IPR001164 [Arf GTPase activating protein] ; IPR013724[GIT, Spa2 homology (SHD) domain] ; IPR020683[Ankyrin repeat-containing domain] ; IPR022018[ARF GTPase-activating protein GIT1, C-terminal] ; IPR032352[Arf GTPase-activating protein GIT1/2, coiled-coil domain] -- -- Q3UIB2 Mitogen-activated protein kinase 13 Mapk13 1725.8 1654.3 1610.6 1617.2 1735.5 1651 0.997401922577293 0.933281317758132 -0.00375311096388925 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) p38 MAP kinase 2.7.11.24 ko01522 Endocrine resistance ko04010 MAPK signaling pathway ko04015 Rap1 signaling pathway ko04068 FoxO signaling pathway ko04071 Sphingolipid signaling pathway ko04218 Cellular senescence ko04261 Adrenergic signaling in cardiomyocytes ko04370 VEGF signaling pathway ko04380 Osteoclast differentiation ko04550 Signaling pathways regulating pluripotency of stem cells ko04611 Platelet activation ko04620 Toll-like receptor signaling pathway ko04621 NOD-like receptor signaling pathway ko04622 RIG-I-like receptor signaling pathway ko04657 IL-17 signaling pathway ko04658 Th1 and Th2 cell differentiation ko04659 Th17 cell differentiation ko04660 T cell receptor signaling pathway ko04664 Fc epsilon RI signaling pathway ko04668 TNF signaling pathway ko04670 Leukocyte transendothelial migration ko04722 Neurotrophin signaling pathway ko04723 Retrograde endocannabinoid signaling ko04728 Dopaminergic synapse ko04750 Inflammatory mediator regulation of TRP channels ko04912 GnRH signaling pathway ko04914 Progesterone-mediated oocyte maturation ko04917 Prolactin signaling pathway ko04926 Relaxin signaling pathway ko04933 AGE-RAGE signaling pathway in diabetic complications ko05014 Amyotrophic lateral sclerosis (ALS) ko05132 Salmonella infection ko05133 Pertussis ko05140 Leishmaniasis ko05142 Chagas disease (American trypanosomiasis) ko05145 Toxoplasmosis ko05152 Tuberculosis ko05160 Hepatitis C ko05164 Influenza A ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05169 Epstein-Barr virus infection ko05205 Proteoglycans in cancer ko05418 Fluid shear stress and atherosclerosis Mitogen-activated protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q5NCI4 Phosphoglycerate mutase Pgam2 84.2 77 68.4 75.7 90.7 74.2 0.954280964256027 0.626753408293719 -0.0675140005003887 Nonsignificant None -- -- 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 5.4.2.11 ko00010 Glycolysis / Gluconeogenesis ko00260 Glycine, serine and threonine metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids ko04922 Glucagon signaling pathway ko05230 Central carbon metabolism in cancer Phosphoglycerate mutase G Carbohydrate transport and metabolism ; IPR013078 [Histidine phosphatase superfamily, clade-1] -- -- Q3UDC3 Target of Myb protein 1 Tom1 1486.7 1413.8 1530.4 1518.7 1584.8 1656.3 0.930900458002437 0.104093467549355 -0.103301187494351 Nonsignificant None 2 Cellular Component:intracellular (GO:0005622),Biological Process:intracellular protein transport (GO:0006886) -- -- -- Cytosolic sorting protein GGA2/TOM1 U Intracellular trafficking, secretion, and vesicular transport ; IPR002014 [VHS domain] ; IPR004152[GAT domain] -- -- D3YZ09 H/ACA ribonucleoprotein complex subunit (Fragment) Gar1 2672.2 2534.6 2717.3 2418.3 2507.6 2588.8 1.05447988608993 0.138050261113314 0.0765315763880617 Nonsignificant None 2 Biological Process:pseudouridine synthesis (GO:0001522),Biological Process:ribosome biogenesis (GO:0042254) H/ACA ribonucleoprotein complex subunit 1 -- ko03008 Ribosome biogenesis in eukaryotes H/ACA small nucleolar RNP component GAR1 J Translation, ribosomal structure and biogenesis ; IPR007504 [H/ACA ribonucleoprotein complex, subunit Gar1/Naf1] -- -- Q9R078 5-AMP-activated protein kinase subunit beta-1 Prkab1 1352.7 1262 902.8 851.2 881 980.6 1.29663078737835 0.133593675892636 0.374767733985827 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) 5'-AMP-activated protein kinase, regulatory beta subunit -- ko04068 FoxO signaling pathway ko04152 AMPK signaling pathway ko04211 Longevity regulating pathway ko04213 Longevity regulating pathway - multiple species ko04371 Apelin signaling pathway ko04530 Tight junction ko04710 Circadian rhythm ko04910 Insulin signaling pathway ko04920 Adipocytokine signaling pathway ko04921 Oxytocin signaling pathway ko04922 Glucagon signaling pathway ko04931 Insulin resistance ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05410 Hypertrophic cardiomyopathy (HCM) Protein involved in Snf1 protein kinase complex assembly G Carbohydrate transport and metabolism ; IPR006828 [Association with the SNF1 complex (ASC) domain] ; IPR032640[AMP-activated protein kinase, glycogen-binding domain] -- -- Q5BLK2 40S ribosomal protein S20 Rps20 3841.6 3868.6 3328.9 2773.5 2818.4 2673.8 1.3355311709837 0.00690487541809129 0.417413648529225 Nonsignificant None -- -- small subunit ribosomal protein S20e -- ko03010 Ribosome 40S ribosomal protein S20 J Translation, ribosomal structure and biogenesis ; IPR027486 [Ribosomal protein S10 domain] -- -- Q8BWZ3 N-alpha-acetyltransferase 25, NatB auxiliary subunit Naa25 603 598.1 602.3 524.7 533.4 508.8 1.15093496713255 0.00043116682964355 0.202806317183435 Nonsignificant None -- -- N-terminal acetyltransferase B complex non-catalytic subunit -- -- Mitochondrial inheritance and actin cytoskeleton organization protein Z Cytoskeleton ; IPR019183 [N-acetyltransferase B complex, non-catalytic subunit] -- -- Q9JIK9 28S ribosomal protein S34, mitochondrial Mrps34 1601.2 1391.3 1361.7 1351.4 1436.1 1438.5 1.03033601514434 0.624227346221821 0.0431149085999344 Nonsignificant None 2 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:mitochondrion (GO:0005739) small subunit ribosomal protein S34 -- -- -- -- -- IPR032053 [Mitochondrial 28S ribosomal protein S34] -- -- Q545I1 C-type lectin domain-containing protein Reg3g 927 1040.8 2498.9 702.4 678.8 587 2.26943400060969 0.241164459314352 1.18233253261261 Nonsignificant None -- -- -- -- -- C-type lectin TV Signal transduction mechanisms ; Defense mechanisms ; IPR001304 [C-type lectin-like] -- -- Q9WVQ5 Methylthioribulose-1-phosphate dehydratase Apip 1094.8 1064.8 1021.8 1092.5 1039.4 1143.8 0.971212259974967 0.441601935262546 -0.0421414615006776 Nonsignificant None -- -- methylthioribulose-1-phosphate dehydratase 4.2.1.109 ko00270 Cysteine and methionine metabolism ko01100 Metabolic pathways Class II aldolase/adducin N-terminal domain protein G Carbohydrate transport and metabolism ; IPR001303 [Class II aldolase/adducin N-terminal] -- -- P23927 Alpha-crystallin B chain Cryab 903.3 970.4 680 572.5 585.7 497.2 1.54264830252507 0.0312433590627747 0.625409189558058 Significant up 1 Molecular Function:structural constituent of eye lens (GO:0005212) crystallin, alpha B -- ko04141 Protein processing in endoplasmic reticulum ko04213 Longevity regulating pathway - multiple species Alpha crystallins O Posttranslational modification, protein turnover, chaperones ; IPR002068 [Alpha crystallin/Hsp20 domain] ; IPR003090[Alpha-crystallin, N-terminal] -- -- Q8K157 Galactose mutarotase Galm 2415.5 2771.8 3088.2 2899 2794.3 2776 0.977117353264142 0.76063697722485 -0.033396252443024 Nonsignificant None 2 Biological Process:carbohydrate metabolic process (GO:0005975),Molecular Function:isomerase activity (GO:0016853) aldose 1-epimerase 5.1.3.3 ko00010 Glycolysis / Gluconeogenesis ko00052 Galactose metabolism ko01100 Metabolic pathways Predicted mutarotase G Carbohydrate transport and metabolism ; IPR008183 [Aldose 1-/Glucose-6-phosphate 1-epimerase] -- -- O54962 Barrier-to-autointegration factor Banf1 1797.9 2072.2 1596 1399.7 1478.5 1508.8 1.24597674948712 0.0641766287542221 0.317277147244263 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) barrier-to-autointegration factor -- -- DNA-bridging protein BAF BL Chromatin structure and dynamics ; Replication, recombination and repair ; IPR004122 [Barrier- to-autointegration factor, BAF] -- -- A2A7K5 c-Myc-binding protein Mycbp 1171.5 1129.8 1189.4 1210.4 1244.6 1245 0.943432432432432 0.029549344579034 -0.0840088975547561 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q8CGA1 Interleukin-1 Il1rn 1104.4 1051.2 1012.5 1480 1507 1572.8 0.694789245142331 0.000267333065514102 -0.525352672589075 Nonsignificant None 4 Molecular Function:cytokine activity (GO:0005125),Cellular Component:extracellular space (GO:0005615),Biological Process:inflammatory response (GO:0006954),Biological Process:immune response (GO:0006955) interleukin 1 receptor antagonist -- -- -- -- -- IPR000975 [Interleukin-1 family] -- -- A0A2R8VHM4 Mitochondrial import receptor subunit TOM22 homolog Tomm22 790.3 813.4 806.1 786.6 817 838.1 0.986935331940861 0.552743276586213 -0.0189725384171739 Nonsignificant None -- -- mitochondrial import receptor subunit TOM22 -- -- Translocase of outer mitochondrial membrane complex, subunit TOM22 U Intracellular trafficking, secretion, and vesicular transport ; -- -- -- Q5XG71 Small subunit processome component 20 homolog Utp20 582.2 548.8 563 475.2 446.4 507.5 1.18536141627598 0.0118090442632873 0.245327003403348 Nonsignificant None -- -- U3 small nucleolar RNA-associated protein 20 -- -- DRIM (Down-regulated in metastasis)-like proteins V Defense mechanisms ; IPR011430 [Down-regulated-in-metastasis protein] -- -- Q3TFC0 RNA helicase Mov10 1066.5 1021 1007 941.5 1051 982.1 1.04030794056344 0.336910036712519 0.057010642370349 Nonsignificant None -- -- helicase MOV-10 3.6.4.13 -- RNA helicase A RNA processing and modification ; -- -- -- Q9DB29 Isoamyl acetate-hydrolyzing esterase 1 homolog Iah1 1214.2 1185.4 1400.7 1574.1 1492.3 1617.9 0.811284503554426 0.0185622267795589 -0.301720163318478 Nonsignificant None -- -- -- -- -- Isoamyl acetate-hydrolyzing esterase I Lipid transport and metabolism ; IPR013830 [SGNH hydrolase-type esterase domain] -- -- Q9R016 Baculoviral IAP repeat-containing protein 1e Naip5 356.4 356 345.1 357.2 541.7 633.2 0.690229097317407 0.190380710426163 -0.534852801538898 Nonsignificant None -- -- baculoviral IAP repeat-containing protein 1 -- ko04621 NOD-like receptor signaling pathway ko05134 Legionellosis -- -- -- IPR001370 [BIR repeat] -- -- Q9JJL8 Serine--tRNA ligase, mitochondrial Sars2 502.2 568.5 583 558.1 642.7 594.7 0.921024784182679 0.247179454997799 -0.11868811605571 Nonsignificant None 4 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation for protein translation (GO:0006418) seryl-tRNA synthetase 6.1.1.11 ko00970 Aminoacyl-tRNA biosynthesis Seryl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR002314 [Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)] ; IPR015866[Serine-tRNA synthetase, type1, N-terminal] -- -- D3YZZ5 Transmembrane p24-trafficking protein 7 Tmed7 671.7 707.7 700.6 730.1 753.1 775.2 0.921006021962451 0.0251764866097561 -0.118717505533876 Nonsignificant None 2 Biological Process:transport (GO:0006810),Cellular Component:integral component of membrane (GO:0016021) p24 family protein gamma-3 -- -- emp24/gp25L/p24 family of membrane trafficking proteins U Intracellular trafficking, secretion, and vesicular transport ; IPR009038 [GOLD domain] -- -- B7ZC46 Septin Septin8 355.2 315.2 359.4 353.7 304.5 401.1 0.972151420749552 0.768695171118181 -0.0407470516832996 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) septin 6/8/11 -- ko05100 Bacterial invasion of epithelial cells Septins (P-loop GTPases) D Cell cycle control, cell division, chromosome partitioning ; IPR030379 [Septin-type guanine nucleotide-binding (G) domain] -- -- Q3UI84 Replication factor C subunit 4 Rfc4 1185.5 1283.4 1272.1 1049.6 1083.2 983 1.20065472751781 0.00815599337049573 0.263821334629238 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) replication factor C subunit 2/4 -- ko03030 DNA replication ko03420 Nucleotide excision repair ko03430 Mismatch repair Replication factor C, subunit RFC4 L Replication, recombination and repair ; IPR003959 [ATPase, AAA-type, core] ; IPR013748[Replication factor C, C-terminal] -- -- Q5M9P7 Calcium regulated heat stable protein 1 Carhsp1 2128.2 1994.4 2160.7 2150.9 2204.9 2124.2 0.969645061728395 0.307800275162127 -0.0444713490246492 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) -- -- -- Predicted RNA-binding protein containing PIN domain and invovled in translation or RNA processing J Translation, ribosomal structure and biogenesis ; IPR002059 [Cold-shock protein, DNA-binding] -- CSD Q8BUU7 N-acetylgalactosamine kinase Galk2 1296.7 1232.1 1423.2 1505.1 1473.7 1614.8 0.86032741205155 0.0387474171045099 -0.217042288735142 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) N-acetylgalactosamine kinase 2.7.1.157 -- Galactokinase G Carbohydrate transport and metabolism ; IPR006204 [GHMP kinase N-terminal domain] ; IPR013750[GHMP kinase, C-terminal domain] ; IPR019539[Galactokinase galactose-binding domain] -- -- Q8JZX4 Splicing factor 45 Rbm17 1712.8 1731.6 1668.3 1599.3 1629.5 1572.6 1.06483525638355 0.0141527178114024 0.0906302443636213 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) splicing factor 45 -- ko03040 Spliceosome mRNA splicing factor A RNA processing and modification ; IPR000467 [G-patch domain] ; IPR000504[RNA recognition motif domain] -- -- A0ZVB6 TBP-associated factor 170 Btaf1 639 642.3 597.3 568.3 554 582.3 1.10207673354453 0.0251610305072551 0.140224676949129 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) TATA-binding protein-associated factor 3.6.4.- -- SNF2 family DNA-dependent ATPase domain-containing protein K Transcription ; IPR000330 [SNF2-related, N-terminal domain] ; IPR001650[Helicase, C-terminal] ; IPR022707[Domain of unknown function DUF3535] -- -- Q99M47 Caspase-6 Casp6 577.8 562.5 683.6 597.8 589.9 611.4 1.01378467011283 0.840846091929502 0.0197512535740516 Nonsignificant None -- -- caspase 6 3.4.22.59 ko04210 Apoptosis Caspase, apoptotic cysteine protease D Cell cycle control, cell division, chromosome partitioning ; -- -- -- Q9JI78 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase Ngly1 1390.5 1371 1378.7 1364.4 1401.4 1400.7 0.9936877475099 0.550652843119008 -0.00913551864395227 Nonsignificant None 2 Cellular Component:cytoplasm (GO:0005737),Biological Process:glycoprotein catabolic process (GO:0006516) peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase 3.5.1.52 ko04141 Protein processing in endoplasmic reticulum Peptide:N-glycanase O Posttranslational modification, protein turnover, chaperones ; IPR002931 [Transglutaminase-like] ; IPR006588[Peptide N glycanase, PAW domain] ; IPR018997[PUB domain] -- -- Q71FD7 Filamin-binding LIM protein 1 Fblim1 1464.9 1458.3 1354 1363.6 1366.2 1286.3 1.06501332138144 0.121919453838818 0.0908714760574467 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) -- -- -- Focal adhesion adaptor protein Paxillin and related LIM proteins T Signal transduction mechanisms ; IPR001781 [Zinc finger, LIM-type] -- -- Q99KR8 Plasma alpha-L-fucosidase Fuca2 1116.8 988.6 1310.9 1454 1450.7 1407.7 0.792203877191355 0.0823955266832381 -0.336056332812903 Nonsignificant None 2 Molecular Function:alpha-L-fucosidase activity (GO:0004560),Biological Process:carbohydrate metabolic process (GO:0005975) alpha-L-fucosidase 3.2.1.51 ko00511 Other glycan degradation Alpha-L-fucosidase G Carbohydrate transport and metabolism ; IPR000933 [Glycoside hydrolase, family 29] ; IPR031919[Alpha-L-fucosidase, C-terminal] -- -- Q792Y6 Pancreatic trypsin Prss2 1492 1125.4 1718.6 761.8 885.6 787 1.78113703581991 0.0231035580084033 0.832798517726638 Significant up 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) trypsin 3.4.21.4 ko04080 Neuroactive ligand-receptor interaction ko04972 Pancreatic secretion ko04974 Protein digestion and absorption ko05164 Influenza A Trypsin E Amino acid transport and metabolism ; IPR001254 [Serine proteases, trypsin domain] -- -- Q6P1Y9 Exocyst complex component 1 Exoc1 947.6 951.4 990.2 936.8 997.5 966.8 0.995898107614353 0.866804515553153 -0.00592995014334176 Nonsignificant None 2 Cellular Component:exocyst (GO:0000145),Biological Process:exocytosis (GO:0006887) exocyst complex component 1 -- -- Exocyst protein Sec3 U Intracellular trafficking, secretion, and vesicular transport ; IPR019160 [Exocyst complex component Sec3, C-terminal] ; IPR028258[Exocyst complex component Sec3, PIP2-binding N-terminal domain] -- -- Q80UW8 DNA-directed RNA polymerases I, II, and III subunit RPABC1 Polr2e 999.8 1046.3 1149.6 1037.2 1047 1061.6 1.01586241973425 0.729438530048909 0.0227050282840768 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Molecular Function:DNA-directed 5'-3' RNA polymerase activity (GO:0003899),Cellular Component:nucleus (GO:0005634) DNA-directed RNA polymerases I, II, and III subunit RPABC1 -- ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways ko03020 RNA polymerase ko04623 Cytosolic DNA-sensing pathway ko05016 Huntington's disease ko05169 Epstein-Barr virus infection RNA polymerase, 25-kDa subunit (common to polymerases I, II and III) K Transcription ; IPR000783 [RNA polymerase, subunit H/Rpb5 C-terminal] ; IPR005571[RNA polymerase, Rpb5, N-terminal] -- -- Q8BIG7 Catechol O-methyltransferase domain-containing protein 1 Comtd1 535.4 521.9 556.1 752.2 713.6 725.3 0.736342476381726 0.000220622298232125 -0.441551168199972 Nonsignificant None 1 Molecular Function:O-methyltransferase activity (GO:0008171) -- -- -- O-methyltransferase Q Secondary metabolites biosynthesis, transport and catabolism ; IPR002935 [O-methyltransferase, family 3] -- -- Q3UKW1 SERPIN domain-containing protein Serpina6 2638.3 2504.4 1928.8 1638.6 1581.7 1782.5 1.41350843527625 0.0378323692903274 0.499280492645492 Nonsignificant None -- -- serpin peptidase inhibitor, clade A -- -- Serpin V Defense mechanisms ; IPR023796 [Serpin domain] -- -- Q99KK9 Histidine--tRNA ligase, mitochondrial Hars2 411.2 431.3 455.3 491.5 517.8 452.6 0.88774882002873 0.074671771259811 -0.171776557230337 Nonsignificant None -- -- histidyl-tRNA synthetase 6.1.1.21 ko00970 Aminoacyl-tRNA biosynthesis Histidyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR004154 [Anticodon-binding] -- -- Q80W22 Threonine synthase-like 2 Thnsl2 540.5 533 554.5 679.2 635.9 689.6 0.812091584775777 0.00204490867292867 -0.300285656330307 Nonsignificant None -- -- -- -- -- Pyridoxalphosphate-dependent enzyme/predicted threonine synthase E Amino acid transport and metabolism ; IPR001926 [Tryptophan synthase beta subunit-like PLP-dependent enzyme] ; IPR029144[Threonine synthase, N-terminal] -- -- Q3TWW8 Serine/arginine-rich splicing factor 6 Srsf6 1057.7 1005.2 1102.9 1012.6 1002.6 931 1.07453669133121 0.127628455487239 0.103714746141974 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) splicing factor, arginine/serine-rich 4/5/6 -- ko03040 Spliceosome ko05168 Herpes simplex infection Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- Q8VBX5 Palmitoyl-protein thioesterase 1 Ppt1 746.5 746.5 859.2 822.7 843.5 856.8 0.932302814110186 0.216714269058558 -0.101129473205813 Nonsignificant None 1 Molecular Function:palmitoyl hydrolase activity (GO:0098599) palmitoyl-protein thioesterase 3.1.2.22 ko00062 Fatty acid elongation ko01100 Metabolic pathways ko01212 Fatty acid metabolism ko04142 Lysosome Palmitoyl protein thioesterase IO Lipid transport and metabolism ; Posttranslational modification, protein turnover, chaperones ; IPR002472 [Palmitoyl protein thioesterase] -- -- Q3TQE0 Hexokinase Hk3 32.9 57.7 40.1 14.9 25.6 15 2.35495495495496 0.0374547548513509 1.23569946455797 Significant up 2 Molecular Function:ATP binding (GO:0005524),Biological Process:carbohydrate metabolic process (GO:0005975) hexokinase 2.7.1.1 ko00010 Glycolysis / Gluconeogenesis ko00051 Fructose and mannose metabolism ko00052 Galactose metabolism ko00500 Starch and sucrose metabolism ko00520 Amino sugar and nucleotide sugar metabolism ko00524 Neomycin, kanamycin and gentamicin biosynthesis ko01100 Metabolic pathways ko01200 Carbon metabolism ko04066 HIF-1 signaling pathway ko04910 Insulin signaling pathway ko04930 Type II diabetes mellitus ko04973 Carbohydrate digestion and absorption ko05230 Central carbon metabolism in cancer Hexokinase G Carbohydrate transport and metabolism ; IPR022672 [Hexokinase, N-terminal] ; IPR022673[Hexokinase, C-terminal] -- -- B2RR26 NHL repeat containing 2 Nhlrc2 1988.4 1880.5 1837.3 1980.1 2047.8 2046.1 0.939446822522226 0.0708751606422303 -0.0901165948224154 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR001258 [NHL repeat] ; IPR012336[Thioredoxin-like fold] -- -- E9QN31 Probable 28S rRNA (cytosine-C(5))-methyltransferase Nop2 2561.4 2616 2081.3 1814 1855.1 1861.7 1.31241411730672 0.0759587318661996 0.392223017758099 Nonsignificant None 1 Molecular Function:methyltransferase activity (GO:0008168) 25S rRNA (cytosine2870-C5)-methyltransferase 2.1.1.310 -- tRNA and rRNA cytosine-C5-methylase (nucleolar protein NOL1/NOP2) A RNA processing and modification ; IPR001678 [SAM-dependent methyltransferase RsmB/NOP2-type] ; IPR012586[P120R repeat] ; IPR031341[Ribosomal RNA small subunit methyltransferase F, N-terminal] -- -- Q5SSZ5 Tensin-3 Tns3 799.9 766.8 882 922 886.9 929.6 0.894175643600511 0.0579763107452211 -0.161369845959754 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) tensin -- -- Clathrin coat dissociation kinase GAK/PTEN/Auxilin and related tyrosine phosphatases TR Signal transduction mechanisms ; General function prediction only ; IPR000980 [SH2 domain] ; IPR013625[Tensin/EPS8 phosphotyrosine-binding domain] ; IPR014020[Tensin phosphatase, C2 domain] -- -- Q3TH64 Cytochrome b5 heme-binding domain-containing protein Cyb5b 1378.7 1328.6 1455.6 1515.5 1483.1 1528.2 0.91961208800919 0.0366921936567682 -0.120902664937952 Nonsignificant None -- -- -- -- -- Cytochrome b5 C Energy production and conversion ; IPR001199 [Cytochrome b5-like heme/steroid binding domain] -- -- E9PUK6 Serine/arginine repetitive matrix protein 1 Srrm1 381.7 365.7 432.5 364.3 350.7 379.7 1.07782954234037 0.262778729213772 0.10812903535843 Nonsignificant None 1 Biological Process:mRNA processing (GO:0006397) serine/arginine repetitive matrix protein 1 -- ko03013 RNA transport ko03015 mRNA surveillance pathway Splicing coactivator SRm160/300, subunit SRm160 (contains PWI domain) AR RNA processing and modification ; General function prediction only ; IPR002483 [PWI domain] -- -- Q9JHS3 Ragulator complex protein LAMTOR2 Lamtor2 820.4 749.4 593.5 716.6 736.9 781 0.96813604833296 0.750454138071066 -0.0467182969084906 Nonsignificant None -- -- ragulator complex protein LAMTOR2 -- ko04150 mTOR signaling pathway MP1 adaptor interacting protein P14 T Signal transduction mechanisms ; IPR004942 [Roadblock/LAMTOR2 domain] -- -- A0A4P3APB9 Non-specific serine/threonine protein kinase Mapkapk2 354.5 398.9 376.7 379 429.3 390.8 0.942456842631974 0.311526867734216 -0.0855015394730544 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) mitogen-activated protein kinase-activated protein kinase 2 2.7.11.1 ko04010 MAPK signaling pathway ko04218 Cellular senescence ko04370 VEGF signaling pathway ko04722 Neurotrophin signaling pathway ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05203 Viral carcinogenesis MAP kinase-activated protein kinase 2 T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- F7BGR7 Predicted gene 21992 Gm21992 294.1 265.8 266.5 262.6 286.7 271.3 1.0070679990251 0.876589451962077 0.0101610999725246 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:zinc ion binding (GO:0008270) RNA-binding protein 4 -- -- RNA-binding protein LARK, contains RRM and retroviral-type Zn-finger domains AR RNA processing and modification ; General function prediction only ; IPR000504 [RNA recognition motif domain] ; IPR001878[Zinc finger, CCHC-type] -- -- Q564F6 Programmed cell death 5 Pdcd5 1717 1707.6 1681.8 1602.2 1674.8 1605.1 1.04594334405276 0.0450083002422849 0.0648047067781449 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) programmed cell death protein 5 -- -- Apoptosis-related protein/predicted DNA-binding protein D Cell cycle control, cell division, chromosome partitioning ; IPR002836 [PDCD5-related protein] -- -- Q99L20 Glutathione S-transferase theta-3 Gstt3 1228.2 1236.3 1304 1435.9 1428.4 1507.6 0.861982204533498 0.00447558883454281 -0.214270009443386 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) glutathione S-transferase 2.5.1.18 ko00480 Glutathione metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko01524 Platinum drug resistance ko05200 Pathways in cancer ko05204 Chemical carcinogenesis ko05225 Hepatocellular carcinoma ko05418 Fluid shear stress and atherosclerosis Glutathione S-transferase O Posttranslational modification, protein turnover, chaperones ; IPR004045 [Glutathione S-transferase, N-terminal] ; IPR004046[Glutathione S-transferase, C-terminal] -- -- Q9CQM5 Thioredoxin domain-containing protein 17 Txndc17 1246.8 1169 1155.6 1217.7 1238 1316.7 0.946718269536635 0.181484074441624 -0.0789929317211875 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR010357 [Protein of unknown function DUF953, thioredoxin-like] -- -- Q9JMG2 C1GALT1-specific chaperone 1 C1galt1c1 963.7 964.3 1451 1497.3 1412.2 1420 0.780459637371521 0.126543042831831 -0.357604071870172 Nonsignificant None -- -- C1GALT1-specific chaperone 1 2.4.1.- ko00512 Mucin type O-glycan biosynthesis ko01100 Metabolic pathways Galactosyltransferases G Carbohydrate transport and metabolism ; -- -- -- Q543N4 Uncharacterized protein Bysl 1661.5 1717.4 1554 1323.5 1263.2 1313.3 1.26484615384615 0.00259189172450049 0.338961917266622 Nonsignificant None -- -- essential nuclear protein 1 -- -- Cell adhesion complex protein bystin W Extracellular structures ; IPR007955 [Bystin] -- -- P98078 Disabled homolog 2 Dab2 1745 1914 1599.1 1407.2 1542.3 1525.6 1.17496815713615 0.0601260367880608 0.23262165877814 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) disabled homolog 2 -- ko04144 Endocytosis Adaptor protein Disabled T Signal transduction mechanisms ; IPR006020 [PTB/PI domain] -- -- Q3U055 Procollagen-lysine 5-dioxygenase Plod2 836.9 886.5 689.6 642.7 691.5 671.9 1.20283136433877 0.0895398413181839 0.266434392401049 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 1.14.11.4 ko00310 Lysine degradation Lysyl hydroxylase O Posttranslational modification, protein turnover, chaperones ; IPR005123 [Oxoglutarate/iron-dependent dioxygenase] -- -- Q91X52 L-xylulose reductase Dcxr 2141.5 1973.8 2077.1 2374.8 2298.9 2586.7 0.852900666629938 0.0228432443374032 -0.229550367535184 Nonsignificant None -- -- L-xylulose reductase 1.1.1.10 ko00040 Pentose and glucuronate interconversions ko01100 Metabolic pathways Diacetyl reductase/L-xylulose reductase Q Secondary metabolites biosynthesis, transport and catabolism ; -- -- -- Q99LI8 Hepatocyte growth factor-regulated tyrosine kinase substrate Hgs 1829.3 1797 1856.5 1912.3 1891.4 1984.3 0.947270214236351 0.0367529836832597 -0.0781520734894824 Nonsignificant None 2 Biological Process:intracellular protein transport (GO:0006886),Molecular Function:metal ion binding (GO:0046872) hepatocyte growth factor-regulated tyrosine kinase substrate -- ko04144 Endocytosis ko04145 Phagosome Membrane trafficking and cell signaling protein HRS, contains VHS and FYVE domains TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR000306 [FYVE zinc finger] ; IPR002014[VHS domain] ; IPR024641[Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain] -- -- Q99KB8 Hydroxyacylglutathione hydrolase, mitochondrial Hagh 815.6 773.5 1003.1 1353.3 1111.9 1319.4 0.684933678592189 0.018346225173342 -0.545963794695039 Nonsignificant None -- -- hydroxyacylglutathione hydrolase 3.1.2.6 ko00620 Pyruvate metabolism Glyoxylase R General function prediction only ; IPR001279 [Metallo-beta-lactamase] ; IPR032282[Hydroxyacylglutathione hydrolase, C-terminal domain] -- -- Q8R1T1 Charged multivesicular body protein 7 Chmp7 414.5 390.7 381.9 430.9 437.4 387.7 0.945143312101911 0.279736854716614 -0.0813949930851321 Nonsignificant None 1 Biological Process:vacuolar transport (GO:0007034) charged multivesicular body protein 7 -- ko04144 Endocytosis ko04217 Necroptosis Uncharacterized conserved protein S Function unknown ; IPR005024 [Snf7 family] -- -- Q3U5F9 Conserved oligomeric Golgi complex subunit 8 Cog8 645.5 675.3 632.2 743.5 724.6 688.5 0.905592135769266 0.0299025850497351 -0.143066665136232 Nonsignificant None 1 Cellular Component:Golgi transport complex (GO:0017119) conserved oligomeric Golgi complex subunit 8 -- -- Golgi transport complex subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR007255 [Conserved oligomeric Golgi complex subunit 8] -- -- Q80X85 28S ribosomal protein S7, mitochondrial Mrps7 995.6 961.1 1263 1146.9 1255.8 1164.8 0.902508759635599 0.315790572429749 -0.147987160204441 Nonsignificant None -- -- small subunit ribosomal protein S7 -- ko03010 Ribosome Ribosomal protein S7 J Translation, ribosomal structure and biogenesis ; IPR023798 [Ribosomal protein S7 domain] -- -- Q497J0 Cystatin domain-containing 5 Cstdc5 206.2 337.4 203.9 28.9 31.5 39.2 7.50502008032128 0.0387124335596286 2.90785593190475 Significant up 1 Molecular Function:cysteine-type endopeptidase inhibitor activity (GO:0004869) -- -- -- -- -- -- IPR000010 [Cystatin domain] -- -- P17439 Lysosomal acid glucosylceramidase Gba 780.6 734.5 933.1 890.2 924.6 893.1 0.904095424498689 0.22895097705683 -0.145453042174398 Nonsignificant None -- -- glucosylceramidase 3.2.1.45 ko00511 Other glycan degradation ko00600 Sphingolipid metabolism ko01100 Metabolic pathways ko04142 Lysosome Beta-glucocerebrosidase G Carbohydrate transport and metabolism ; IPR033452 [Glycosyl hydrolase family 30, beta sandwich domain] ; IPR033453[Glycosyl hydrolase family 30, TIM-barrel domain] -- -- Q9CZG9 PDZ domain-containing protein 11 Pdzd11 900.5 859.4 968.2 1019.5 970.6 1018.4 0.906797407345853 0.0583740235344553 -0.141147828659377 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- FOG: PDZ domain S Function unknown ; IPR001478 [PDZ domain] -- -- Q9D6S7 Ribosome-recycling factor, mitochondrial Mrrf 507.8 434.5 440.4 461.6 430.9 497 0.995106153292551 0.943942273417473 -0.0070776610301194 Nonsignificant None -- -- ribosome recycling factor -- -- Ribosome recycling factor J Translation, ribosomal structure and biogenesis ; IPR023584 [Ribosome recycling factor domain] -- -- Q8C671 Serine/arginine-rich splicing factor 2 Srsf2 1096.5 1115.8 1060.3 1096.4 1119.1 996.1 1.01899364802591 0.647057449649669 0.0271450583829346 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) splicing factor, arginine/serine-rich 2 -- ko03040 Spliceosome ko05168 Herpes simplex infection Predicted splicing factor, SR protein superfamily A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- D3YXZ3 Kinesin light chain Klc2 266.6 277.3 238.8 371.4 401.1 289 0.737352802637777 0.0586592304273133 -0.439573021254131 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) kinesin light chain -- ko05132 Salmonella infection Kinesin light chain Z Cytoskeleton ; IPR011990 [Tetratricopeptide-like helical domain] -- -- Q9JKF7 39S ribosomal protein L39, mitochondrial Mrpl39 2139.7 2034.6 1716.4 1619.1 1666 1773.9 1.16440007906701 0.109724558233336 0.219586842537571 Nonsignificant None -- -- large subunit ribosomal protein L39 -- -- Threonyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; -- -- -- Q3UFY7 7-methylguanosine phosphate-specific 5-nucleotidase Nt5c3b 847.3 899.3 902.3 968.8 922.2 996.5 0.917367965367965 0.0472526483940805 -0.124427565723105 Nonsignificant None 3 Molecular Function:magnesium ion binding (GO:0000287),Cellular Component:cytoplasm (GO:0005737),Molecular Function:5'-nucleotidase activity (GO:0008253) 5'-nucleotidase 3.1.3.5 ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko00760 Nicotinate and nicotinamide metabolism ko01100 Metabolic pathways Uncharacterized conserved protein S Function unknown ; IPR006434 [Pyrimidine 5'-nucleotidase, eukaryotic] -- -- G3UYF9 Prefoldin subunit 6 Pfdn6 1714.5 1744.5 2062 1898.9 2005.3 1863 0.957310306561243 0.528670591572506 -0.0629414531717211 Nonsignificant None 3 Biological Process:protein folding (GO:0006457),Cellular Component:prefoldin complex (GO:0016272),Molecular Function:unfolded protein binding (GO:0051082) prefoldin beta subunit -- -- Prefoldin subunit 6, KE2 family O Posttranslational modification, protein turnover, chaperones ; IPR002777 [Prefoldin beta-like] -- -- Q6PB44 Tyrosine-protein phosphatase non-receptor type 23 Ptpn23 492.2 461.4 491.8 567.4 577.2 514.7 0.87109021876695 0.0313157254626804 -0.199105948477455 Nonsignificant None 3 Molecular Function:protein tyrosine phosphatase activity (GO:0004725),Molecular Function:protein binding (GO:0005515),Biological Process:protein dephosphorylation (GO:0006470) tyrosine-protein phosphatase non-receptor type 23 3.1.3.48 -- Predicted signal transduction protein R General function prediction only ; IPR000242 [PTP type protein phosphatase] ; IPR004328[BRO1 domain] ; IPR025304[ALIX V-shaped domain] -- -- Q9WVA2 Mitochondrial import inner membrane translocase subunit Tim8 A Timm8a1 882.2 903 859.2 946.4 959.6 990.9 0.912837861161932 0.0099967261051202 -0.131569464328052 Nonsignificant None -- -- mitochondrial import inner membrane translocase subunit TIM8 -- -- Mitochondrial import inner membrane translocase, subunit TIM8 U Intracellular trafficking, secretion, and vesicular transport ; IPR004217 [Tim10/DDP family zinc finger] -- -- Q99J36 THUMP domain-containing protein 1 Thumpd1 1751.5 1708.4 1743.9 1702.9 1739.6 1741.6 1.00380008101696 0.737779030854321 0.00547196765034208 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) tRNA acetyltransferase TAN1 -- -- THUMP domain-containing proteins R General function prediction only ; IPR004114 [THUMP domain] -- -- Q9CQC2 Colipase Clps 430.5 384.2 381.6 417 680.6 443.3 0.776364462327211 0.24943544041604 -0.365194013927115 Nonsignificant None 4 Cellular Component:extracellular region (GO:0005576),Biological Process:digestion (GO:0007586),Molecular Function:enzyme activator activity (GO:0008047),Biological Process:lipid catabolic process (GO:0016042) colipase -- ko04975 Fat digestion and absorption -- -- -- IPR017913 [Colipase, N-terminal] ; IPR017914[Colipase, C-terminal] -- -- Q571A2 MKIAA4106 protein (Fragment) Cul2 1116.5 1105.4 1221.8 1221.6 1210.7 1220.8 0.942678820727601 0.199611438146194 -0.0851617796292913 Nonsignificant None 2 Biological Process:ubiquitin-dependent protein catabolic process (GO:0006511),Molecular Function:ubiquitin protein ligase binding (GO:0031625) cullin 2 -- ko04066 HIF-1 signaling pathway ko04120 Ubiquitin mediated proteolysis ko05200 Pathways in cancer ko05211 Renal cell carcinoma E3 ubiquitin ligase, Cullin 2 component O Posttranslational modification, protein turnover, chaperones ; IPR001373 [Cullin, N-terminal] ; IPR019559[Cullin protein, neddylation domain] -- -- Q2VPR3 2500003M10Rik protein (Fragment) Chtop 1648.4 1663.5 1626.5 1617.8 1521.5 1594.1 1.0433092491655 0.0914548497157258 0.0611668530720086 Nonsignificant None -- -- -- -- -- -- -- -- IPR025715 [Chromatin target of PRMT1 protein, C-terminal] -- -- Q8VE47 Ubiquitin-like modifier-activating enzyme 5 Uba5 738.9 681.6 761.9 763.6 725.3 763.1 0.969094138543517 0.439195096673482 -0.0452912779434193 Nonsignificant None 1 Molecular Function:small protein activating enzyme activity (GO:0008641) ubiquitin-like modifier-activating enzyme 5 -- -- Molybdopterin biosynthesis-related protein H Coenzyme transport and metabolism ; IPR000594 [THIF-type NAD/FAD binding fold] -- -- Q8R0F8 Acylpyruvase FAHD1, mitochondrial Fahd1 637.8 546.6 738.8 998.3 786.4 772.6 0.75204317053142 0.0825770687126063 -0.41111261367071 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) acylpyruvate hydrolase 3.7.1.5 ko00350 Tyrosine metabolism ko01100 Metabolic pathways Predicted fumarylacetoacetate hydralase R General function prediction only ; IPR011234 [Fumarylacetoacetase, C-terminal-related] -- -- Q8CD10 Calcium uptake protein 2, mitochondrial Micu2 660.5 673.9 776.5 907.1 988.1 876.4 0.761617838071872 0.0112707789630634 -0.392860826067591 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) -- -- -- Ca2+ binding protein, contains EF-hand motifs P Inorganic ion transport and metabolism ; IPR002048 [EF-hand domain] -- -- O08579 Emerin Emd 1089.9 1177.7 1120.2 1013.8 1061.9 982.3 1.10784826684107 0.033685554255444 0.14776030046106 Nonsignificant None -- -- emerin -- ko05410 Hypertrophic cardiomyopathy (HCM) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05414 Dilated cardiomyopathy (DCM) -- -- -- IPR003887 [LEM domain] -- -- Q8BHG2 CXXC motif containing zinc binding protein Czib 1375.8 1367.9 1318.3 1276.3 1304.6 1367.2 1.02884931992604 0.305366065835363 0.0410317078749635 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR008584 [Protein of unknown function DUF866, eukaryotic] -- -- G3X8T2 Zinc finger CCCH domain-containing protein 18 Zc3h18 949.7 922.5 1006.4 938.5 968 933.9 1.01344881002676 0.660909732430648 0.019273219159371 Nonsignificant None -- -- nuclear protein NHN1 -- -- -- -- -- -- -- -- Q3TB21 Ig-like domain-containing protein Icam1 880.7 996.2 913.6 785.2 850.8 814.8 1.13860780153419 0.0447691859195783 0.18727088996038 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) intercellular adhesion molecule 1 -- ko04064 NF-kappa B signaling pathway ko04514 Cell adhesion molecules (CAMs) ko04650 Natural killer cell mediated cytotoxicity ko04668 TNF signaling pathway ko04670 Leukocyte transendothelial migration ko04933 AGE-RAGE signaling pathway in diabetic complications ko05143 African trypanosomiasis ko05144 Malaria ko05150 Staphylococcus aureus infection ko05164 Influenza A ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05169 Epstein-Barr virus infection ko05323 Rheumatoid arthritis ko05416 Viral myocarditis ko05418 Fluid shear stress and atherosclerosis -- -- -- IPR007110 [Immunoglobulin-like domain] ; IPR013768[Intercellular adhesion molecule, N-terminal] -- -- A0A140LHR3 Signal peptidase complex subunit 2 Spcs2 906.1 888.7 927.8 926.1 914.1 954.4 0.974236026622773 0.218359104327116 -0.0376567607861999 Nonsignificant None 4 Cellular Component:signal peptidase complex (GO:0005787),Biological Process:signal peptide processing (GO:0006465),Molecular Function:peptidase activity (GO:0008233),Cellular Component:integral component of membrane (GO:0016021) signal peptidase complex subunit 2 3.4.-.- ko03060 Protein export Signal peptidase complex, subunit SPC25 U Intracellular trafficking, secretion, and vesicular transport ; IPR009582 [Signal peptidase complex subunit 2] -- -- Q8CBE6 Dystroglycan 1 Dag1 1120.4 1080.7 1122.4 1274.1 1261.7 1302.1 0.865968368117981 0.000690885043820361 -0.207613767386617 Nonsignificant None 2 Biological Process:cytoskeletal anchoring at plasma membrane (GO:0007016),Cellular Component:dystrophin-associated glycoprotein complex (GO:0016010) dystroglycan 1 -- ko04512 ECM-receptor interaction ko05410 Hypertrophic cardiomyopathy (HCM) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05414 Dilated cardiomyopathy (DCM) ko05416 Viral myocarditis Dystroglycan W Extracellular structures ; IPR008465 [Dystroglycan] -- -- Q80UJ7 Rab3 GTPase-activating protein catalytic subunit Rab3gap1 1390.6 1412.7 1256.4 1196.1 1188.1 1210.1 1.12948279219876 0.0839996232224262 0.175662291272277 Nonsignificant None 1 Molecular Function:GTPase activator activity (GO:0005096) Rab3 GTPase-activating protein catalytic subunit -- -- Uncharacterized conserved protein S Function unknown ; IPR026147 [Rab3 GTPase-activating protein catalytic subunit] -- -- P29595 NEDD8 Nedd8 1346.6 1289 790.2 792.7 802.1 757.1 1.45660954972575 0.179245752389902 0.542614208792149 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) ubiquitin-like protein Nedd8 -- -- Ubiquitin-like protein DO Cell cycle control, cell division, chromosome partitioning ; Posttranslational modification, protein turnover, chaperones ; IPR000626 [Ubiquitin domain] -- -- Q6P3A8 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial Bckdhb 522.3 466.7 601.4 716.6 547 871.2 0.74498782087315 0.148174074066217 -0.42471125442603 Nonsignificant None -- -- 2-oxoisovalerate dehydrogenase E1 component beta subunit 1.2.4.4 ko00280 Valine, leucine and isoleucine degradation ko00640 Propanoate metabolism ko01100 Metabolic pathways Branched chain alpha-keto acid dehydrogenase E1, beta subunit C Energy production and conversion ; IPR005475 [Transketolase-like, pyrimidine-binding domain] ; IPR033248[Transketolase, C-terminal domain] -- -- A2AQA7 RNA helicase aquarius Aqr 564.9 535.5 472.6 492.7 518.5 482.4 1.05316014997322 0.416925540357142 0.074724838076847 Nonsignificant None -- -- intron-binding protein aquarius -- ko03040 Spliceosome DEAD box containing helicases L Replication, recombination and repair ; IPR032174 [Intron-binding protein aquarius, N-terminal] -- -- A2AVR9 Dynein light chain roadblock Dynlrb1 1210.9 1044.9 948.2 1005.8 1021.6 1155.3 1.00669243095485 0.941029565262096 0.00962297220847931 Nonsignificant None -- -- dynein light chain roadblock-type -- -- Dynein-associated protein Roadblock DN Cell cycle control, cell division, chromosome partitioning ; Cell motility ; IPR004942 [Roadblock/LAMTOR2 domain] -- -- Q9ET03 Ube1l (Fragment) 671.6 681.3 798.4 825.5 905.5 760 0.863629064632678 0.125332728475412 -0.211516298150566 Nonsignificant None 1 Molecular Function:small protein activating enzyme activity (GO:0008641) ubiquitin-activating enzyme E1-like 6.2.1.45 ko04120 Ubiquitin mediated proteolysis ko05012 Parkinson's disease Ubiquitin activating enzyme UBA1 O Posttranslational modification, protein turnover, chaperones ; IPR000594 [THIF-type NAD/FAD binding fold] ; IPR019572[Ubiquitin-activating enzyme, catalytic cysteine domain] ; IPR032418[Ubiquitin-activating enzyme E1, FCCH domain] ; IPR032420[Ubiquitin-activating enzyme E1, four-helix bundle] -- -- Q80ZJ1 Ras-related protein Rap-2a Rap2a 146.2 103.4 126.9 170.8 148.5 194.2 0.733203505355404 0.0650420667902894 -0.447714411646267 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rap-2A -- -- Ras-related GTPase R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- Q3TEP0 Uncharacterized protein Aaas 325.4 328.1 294.3 337.5 345.4 318.4 0.946569459702387 0.256558408223144 -0.0792197194481992 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) aladin -- ko03013 RNA transport WD40 repeat protein R General function prediction only ; IPR001680 [WD40 repeat] -- -- A0A0R4J1C9 Sulfotransferase Chst4 680.9 721.7 815.2 879.6 808.3 804.3 0.889896477008266 0.121600493652939 -0.168290579924769 Nonsignificant None 1 Molecular Function:sulfotransferase activity (GO:0008146) carbohydrate 6-sulfotransferase 4 2.8.2.- ko00533 Glycosaminoglycan biosynthesis - keratan sulfate -- -- -- IPR000863 [Sulfotransferase domain] -- -- E9PZA7 Transformation/transcription domain-associated protein Trrap 447.6 373 349.8 360.7 408.1 390.1 1.00992320303736 0.912002724453592 0.0142455911853995 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:kinase activity (GO:0016301) transformation/transcription domain-associated protein -- ko05166 HTLV-I infection Histone acetyltransferase SAGA, TRRAP/TRA1 component, PI-3 kinase superfamily TBLD Signal transduction mechanisms ; Chromatin structure and dynamics ; Replication, recombination and repair ; Cell cycle control, cell division, chromosome partitioning ; IPR000403 [Phosphatidylinositol 3-/4-kinase, catalytic domain] ; IPR003151[PIK-related kinase, FAT] -- -- Q9DB22 RPOLD domain-containing protein 942 926.3 892.1 937.6 1019 958.8 0.946834053646155 0.143911636593455 -0.078816500197451 Nonsignificant None 2 Molecular Function:DNA-directed 5'-3' RNA polymerase activity (GO:0003899),Molecular Function:protein dimerization activity (GO:0046983) DNA-directed RNA polymerase II subunit RPB3 -- ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways ko03020 RNA polymerase ko05016 Huntington's disease ko05169 Epstein-Barr virus infection RNA polymerase II, subunit POLR2C/RPB3 K Transcription ; IPR011262 [DNA-directed RNA polymerase, insert domain] ; IPR011263[DNA-directed RNA polymerase, RpoA/D/Rpb3-type] -- -- E9PUG7 Eukaryotic translation initiation factor 2D Eif2d 602.6 576.6 597 586.2 641.6 631 0.955562728642135 0.215427999759439 -0.0655775117626529 Nonsignificant None 2 Molecular Function:translation initiation factor activity (GO:0003743),Biological Process:translational initiation (GO:0006413) translation initiation factor 2D -- -- Filamentous baseplate protein Ligatin, contains PUA domain J Translation, ribosomal structure and biogenesis ; IPR001950 [SUI1 domain] -- -- Q9D0T1 NHP2-like protein 1 Snu13 2521.7 2737.7 2656.3 2436 2468 2583.3 1.05721688726243 0.138220310616707 0.0802713749040595 Nonsignificant None -- -- U4/U6 small nuclear ribonucleoprotein SNU13 -- ko03008 Ribosome biogenesis in eukaryotes ko03040 Spliceosome 60S ribosomal protein 15.5kD/SNU13, NHP2/L7A family (includes ribonuclease P subunit p38), involved in splicing AJ RNA processing and modification ; Translation, ribosomal structure and biogenesis ; IPR004038 [Ribosomal protein L7Ae/L30e/S12e/Gadd45] -- -- P61079 Ubiquitin-conjugating enzyme E2 D3 Ube2d3 990.3 1028.9 1010.8 1073.4 1024 979.5 0.984757385680393 0.622164001231025 -0.0221597627946614 Nonsignificant None -- -- ubiquitin-conjugating enzyme E2 D 2.3.2.23 ko04120 Ubiquitin mediated proteolysis ko04141 Protein processing in endoplasmic reticulum Ubiquitin-protein ligase O Posttranslational modification, protein turnover, chaperones ; IPR000608 [Ubiquitin-conjugating enzyme E2] -- -- Q61878 Bone marrow proteoglycan Prg2 2432 2940.5 1885.4 994.2 1005 923.6 2.48320104009854 0.0408405643248704 1.3122010669163 Significant up -- -- bone marrow proteoglycan -- ko05310 Asthma C-type lectin TV Signal transduction mechanisms ; Defense mechanisms ; IPR001304 [C-type lectin-like] -- -- O88939 Zinc finger and BTB domain-containing protein 7A Zbtb7a 834.4 815.6 855.3 813.1 804.5 847.5 1.01630765486187 0.485051726373049 0.0233371983262977 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:metal ion binding (GO:0046872) zinc finger and BTB domain-containing protein 7 -- -- FOG: Zn-finger R General function prediction only ; IPR000210 [BTB/POZ domain] ; IPR007087[Zinc finger, C2H2] -- ZBTB P99028 Cytochrome b-c1 complex subunit 6, mitochondrial Uqcrh 2014.3 2273.2 2773.9 3248.7 3157.3 3058.9 0.746061765047703 0.0251319354469383 -0.422633021458629 Nonsignificant None -- -- ubiquinol-cytochrome c reductase subunit 6 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04260 Cardiac muscle contraction ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Ubiquinol-cytochrome c reductase hinge protein C Energy production and conversion ; IPR023184 [Ubiquinol-cytochrome C reductase hinge domain] -- -- A2ADY9 Protein DDI1 homolog 2 Ddi2 1878.9 1960.2 2158.5 1725.9 1804.9 1724.1 1.14133475422939 0.0469180857420014 0.190721997091279 Nonsignificant None 3 Molecular Function:aspartic-type endopeptidase activity (GO:0004190),Molecular Function:protein binding (GO:0005515),Biological Process:proteolysis (GO:0006508) DNA damage-inducible protein 1 -- -- DNA damage inducible protein L Replication, recombination and repair ; IPR000626 [Ubiquitin domain] ; IPR019103[Aspartic peptidase, DDI1-type] -- -- G3X9M0 28S ribosomal protein S29, mitochondrial Dap3 1062.8 1033.2 1108.6 1029.8 1072.9 1047.9 1.01713959245858 0.51518516493057 0.0245176885638956 Nonsignificant None -- -- small subunit ribosomal protein S29 -- -- Mitochondrial ribosome small subunit component, mediator of apoptosis DAP3 J Translation, ribosomal structure and biogenesis ; IPR019368 [Ribosomal protein S23/S29, mitochondrial] -- -- Q8VCN9 Tubulin-specific chaperone C Tbcc 1092.1 1099.3 1380.9 1240.3 1268.9 1170.6 0.970786455785641 0.73688070782418 -0.0427741144444618 Nonsignificant None 1 Molecular Function:tubulin binding (GO:0015631) tubulin-specific chaperone C -- -- Beta-tubulin folding cofactor C O Posttranslational modification, protein turnover, chaperones ; IPR012945 [Tubulin binding cofactor C-like domain] ; IPR031925[Tubulin-specific chaperone C, N-terminal] -- -- Q8C3X8 Lipase maturation factor 2 Lmf2 1273.6 1299.4 792.4 774.2 784.8 875.6 1.3823215312577 0.138461628627383 0.46709322903875 Nonsignificant None -- -- -- -- -- -- -- -- IPR009613 [Lipase maturation factor] -- -- P48771 Cytochrome c oxidase subunit 7A2, mitochondrial Cox7a2 2519.8 2394.2 2791.5 2693.1 2721.8 2782.5 0.939993168565643 0.244152161209038 -0.0892778228973879 Nonsignificant None -- -- cytochrome c oxidase subunit 7a -- ko00190 Oxidative phosphorylation ko04260 Cardiac muscle contraction ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease -- -- -- -- -- -- Q91VH6 Protein MEMO1 Memo1 670 654.7 788.5 811.9 802.6 781.6 0.881933141354701 0.0945509178753121 -0.181258804515077 Nonsignificant None -- -- MEMO1 family protein -- -- Predicted dioxygenase R General function prediction only ; IPR002737 [MEMO1 family] -- -- Q5M9P1 Ribosomal protein L36A Rpl36a 5052.2 5214 3112.1 2785.7 2772.4 2544.6 1.65109161143816 0.11935467680055 0.723420170948191 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L44e -- ko03010 Ribosome 60S ribosomal protein L44 J Translation, ribosomal structure and biogenesis ; IPR000552 [Ribosomal protein L44e] -- -- Q3TIJ5 Ribosome biogenesis protein BOP1 Bop1 743 706 620.1 531 588.1 583.3 1.21540178571429 0.0399201898337521 0.281433316659303 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Biological Process:rRNA processing (GO:0006364) ribosome biogenesis protein ERB1 -- -- WD40 repeat nucleolar protein Bop1, involved in ribosome biogenesis J Translation, ribosomal structure and biogenesis ; IPR001680 [WD40 repeat] ; IPR012953[BOP1, N-terminal domain] -- -- Q8VCA5 Transmembrane protease serine 4 Tmprss4 770.2 723.2 839.9 848.1 900.3 831 0.904590214778631 0.108281459173496 -0.144663704894931 Nonsignificant None 3 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508),Cellular Component:membrane (GO:0016020) transmembrane protease serine 4 3.4.21.- ko05164 Influenza A Trypsin E Amino acid transport and metabolism ; IPR001254 [Serine proteases, trypsin domain] ; IPR017448[SRCR-like domain] -- -- Q61229 TAP2 Tap2 714.6 728.4 584.1 526.7 529 588.1 1.23317921888308 0.0635380749025845 0.302382482956248 Nonsignificant None 5 Molecular Function:ATP binding (GO:0005524),Biological Process:transport (GO:0006810),Cellular Component:integral component of membrane (GO:0016021),Molecular Function:ATPase activity (GO:0016887),Biological Process:transmembrane transport (GO:0055085) ATP-binding cassette, subfamily B (MDR/TAP), member 3 -- ko02010 ABC transporters ko04145 Phagosome ko04612 Antigen processing and presentation ko05168 Herpes simplex infection ko05340 Primary immunodeficiency Peptide exporter, ABC superfamily U Intracellular trafficking, secretion, and vesicular transport ; IPR003439 [ABC transporter-like] ; IPR011527[ABC transporter type 1, transmembrane domain] -- -- A0A0R4J094 Fumarylacetoacetate hydrolase domain-containing 2A Fahd2a 1506.7 1474.2 1593.8 1897.5 1790.7 1880.3 0.821531830834156 0.00243883499858685 -0.283611620385257 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) -- -- -- Predicted fumarylacetoacetate hydralase R General function prediction only ; IPR011234 [Fumarylacetoacetase, C-terminal-related] -- -- Q9DBE9 pre-rRNA 2-O-ribose RNA methyltransferase FTSJ3 Ftsj3 491.9 528.7 501.4 432.1 473.8 438.7 1.13193514799941 0.0254054409535873 0.178791304159358 Nonsignificant None 4 Cellular Component:nucleus (GO:0005634),Biological Process:rRNA processing (GO:0006364),Molecular Function:methyltransferase activity (GO:0008168),Biological Process:methylation (GO:0032259) AdoMet-dependent rRNA methyltransferase SPB1 2.1.1.- -- Putative SAM-dependent rRNA methyltransferase SPB1 AR RNA processing and modification ; General function prediction only ; IPR002877 [Ribosomal RNA methyltransferase FtsJ domain] ; IPR012920[Ribosomal RNA methyltransferase, Spb1, C-terminal] ; IPR024576[Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381] -- -- E9PU93 Set1/Ash2 histone methyltransferase complex subunit ASH2 Ash2l 1059 1064.5 1077.9 1058.8 1031.5 1083.1 1.00882334404739 0.589315500261069 0.0126735649498157 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) Set1/Ash2 histone methyltransferase complex subunit ASH2 -- -- Histone H3 (Lys4) methyltransferase complex, subunit CPS60/ASH2/BRE2 BK Chromatin structure and dynamics ; Transcription ; IPR003877 [SPRY domain] -- -- O08832 Polypeptide N-acetylgalactosaminyltransferase 4 Galnt4 1494.4 1504.3 1979.3 1878.2 1926.5 1876 0.876300455929727 0.280188442851509 -0.190502485380166 Nonsignificant None -- -- polypeptide N-acetylgalactosaminyltransferase 2.4.1.41 ko00512 Mucin type O-glycan biosynthesis ko01100 Metabolic pathways Polypeptide N-acetylgalactosaminyltransferase O Posttranslational modification, protein turnover, chaperones ; IPR000772 [Ricin B, lectin domain] ; IPR001173[Glycosyltransferase 2-like] -- -- Q9D0J4 ADP-ribosylation factor-like protein 2 Arl2 493 474.7 470.1 499 506.6 478.1 0.969063826919188 0.237457713821913 -0.045336403708071 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) ADP-ribosylation factor-like protein 2 -- -- GTP-binding ADP-ribosylation factor-like protein ARL2 UZ Intracellular trafficking, secretion, and vesicular transport ; Cytoskeleton ; IPR006689 [Small GTPase superfamily, ARF/SAR type] -- -- A2ATP6 Myelin expression factor 2 Myef2 1439 1478.7 1572.4 1375.2 1499.4 1369.6 1.05793789171104 0.23016644320132 0.0812549337368196 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- -- -- -- IPR000504 [RNA recognition motif domain] -- -- Q8C863 E3 ubiquitin-protein ligase Itchy Itch 730.9 708.8 587.7 528.2 573.9 584 1.20241978530336 0.0755945249995777 0.265940653492166 Nonsignificant None 2 Molecular Function:ubiquitin-protein transferase activity (GO:0004842),Molecular Function:protein binding (GO:0005515) E3 ubiquitin-protein ligase Itchy 2.3.2.26 ko04120 Ubiquitin mediated proteolysis ko04144 Endocytosis ko04668 TNF signaling pathway ko04932 Non-alcoholic fatty liver disease (NAFLD) Ubiquitin protein ligase RSP5/NEDD4 O Posttranslational modification, protein turnover, chaperones ; IPR000008 [C2 domain] ; IPR000569[HECT domain] ; IPR001202[WW domain] -- -- Q9Z2D6 Methyl-CpG-binding protein 2 Mecp2 819.1 805.2 903.7 955.4 979.1 991.6 0.863948600526298 0.0151513062024304 -0.210982611169464 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634) methyl CpG binding protein 2 -- -- Methyl-CpG binding transcription regulators KB Transcription ; Chromatin structure and dynamics ; IPR001739 [Methyl-CpG DNA binding] -- MBD G5E850 Cytochrome b5 Cyb5a 1083.9 1110.2 1233.6 1234.4 1259.5 1182.8 0.9322762259635 0.181475085359537 -0.101170617707117 Nonsignificant None -- -- -- -- -- Cytochrome b5 C Energy production and conversion ; IPR001199 [Cytochrome b5-like heme/steroid binding domain] -- -- A2A5R2 Brefeldin A-inhibited guanine nucleotide-exchange protein 2 Arfgef2 278 315.9 321.7 356.6 341.9 316.2 0.902335665714004 0.141825157789221 -0.148263884047838 Nonsignificant None 2 Molecular Function:ARF guanyl-nucleotide exchange factor activity (GO:0005086),Biological Process:regulation of ARF protein signal transduction (GO:0032012) brefeldin A-inhibited guanine nucleotide-exchange protein -- ko04144 Endocytosis Guanine nucleotide exchange factor U Intracellular trafficking, secretion, and vesicular transport ; IPR000904 [Sec7 domain] ; IPR015403[Sec7, C-terminal] ; IPR032629[Mon2, dimerisation and cyclophilin-binding domain] ; IPR032691[Guanine nucleotide exchange factor, N-terminal] -- -- Q8K2Q7 BRO1 domain-containing protein BROX Brox 739 713.3 767.7 806.6 806.7 778.6 0.928132447008654 0.03505073948659 -0.107597398362042 Nonsignificant None -- -- -- -- -- -- -- -- IPR004328 [BRO1 domain] -- -- Q9JMD0 BUB3-interacting and GLEBS motif-containing protein ZNF207 Znf207 2408.3 2708 2393.4 2208.5 2222.4 2248.2 1.12435807219536 0.112213715947647 0.169101561104415 Nonsignificant None -- -- -- -- -- Zn finger protein R General function prediction only ; -- -- -- Q8R2Y8 Peptidyl-tRNA hydrolase 2, mitochondrial Ptrh2 1227 1157.3 1155.1 1218.9 1245.5 1182.4 0.970549522869365 0.296786739871605 -0.0431262656936942 Nonsignificant None 1 Molecular Function:aminoacyl-tRNA hydrolase activity (GO:0004045) peptidyl-tRNA hydrolase, PTH2 family 3.1.1.29 -- Uncharacterized conserved protein S Function unknown ; IPR002833 [Peptidyl-tRNA hydrolase, PTH2] -- -- Q8K2C7 Protein OS-9 Os9 1255.5 1280.8 1030.1 966.3 1040 911.8 1.22216510743292 0.0698439367529969 0.289439198073388 Nonsignificant None -- -- protein OS-9 -- ko04141 Protein processing in endoplasmic reticulum Protein OS-9 R General function prediction only ; IPR012913 [Glucosidase II beta subunit-like] -- -- P28658 Ataxin-10 Atxn10 1324.6 1298.9 1261.1 1098.2 1117.8 1192.6 1.13964677580238 0.00970532509499174 0.188586742142265 Nonsignificant None -- -- ataxin-10 -- -- Uncharacterized conserved protein S Function unknown ; IPR019156 [Ataxin-10 domain] -- -- A0A0G2JDJ5 Farnesyl pyrophosphate synthase (Fragment) Fdps 319.1 309.1 414.9 480.9 527.5 441.4 0.719478548765347 0.0318334594834573 -0.474976421196565 Nonsignificant None 1 Biological Process:isoprenoid biosynthetic process (GO:0008299) -- -- ko00900 Terpenoid backbone biosynthesis ko01100 Metabolic pathways ko05164 Influenza A ko05166 HTLV-I infection Polyprenyl synthetase H Coenzyme transport and metabolism ; IPR000092 [Polyprenyl synthetase] -- -- P57746 V-type proton ATPase subunit D Atp6v1d 577.4 570.8 649.5 688.1 690.9 690.2 0.868789870481345 0.0694127985440919 -0.202920812522623 Nonsignificant None -- -- V-type H+-transporting ATPase subunit D -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04145 Phagosome ko04150 mTOR signaling pathway ko04721 Synaptic vesicle cycle ko04966 Collecting duct acid secretion ko05323 Rheumatoid arthritis Vacuolar H+-ATPase V1 sector, subunit D C Energy production and conversion ; IPR002699 [ATPase, V1 complex, subunit D] -- -- P61967 AP-1 complex subunit sigma-1A Ap1s1 695.2 654 713.8 713.4 748.9 776.6 0.921434633078744 0.0824310176375025 -0.118046270733007 Nonsignificant None -- -- AP-1 complex subunit sigma 1/2 -- ko04142 Lysosome Clathrin adaptor complex, small subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR022775 [AP complex, mu/sigma subunit] -- -- Q9Z1B3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Plcb1 476.7 433.4 446.5 496.2 471.6 473 0.941560244308717 0.136592771359767 -0.0868746884335907 Nonsignificant None 6 Molecular Function:phosphatidylinositol phospholipase C activity (GO:0004435),Molecular Function:calcium ion binding (GO:0005509),Biological Process:lipid metabolic process (GO:0006629),Biological Process:signal transduction (GO:0007165),Biological Process:lipid catabolic process (GO:0016042),Biological Process:intracellular signal transduction (GO:0035556) phosphatidylinositol phospholipase C, beta 3.1.4.11 ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04015 Rap1 signaling pathway ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04062 Chemokine signaling pathway ko04070 Phosphatidylinositol signaling system ko04071 Sphingolipid signaling pathway ko04072 Phospholipase D signaling pathway ko04261 Adrenergic signaling in cardiomyocytes ko04270 Vascular smooth muscle contraction ko04310 Wnt signaling pathway ko04371 Apelin signaling pathway ko04540 Gap junction ko04611 Platelet activation ko04621 NOD-like receptor signaling pathway ko04713 Circadian entrainment ko04720 Long-term potentiation ko04723 Retrograde endocannabinoid signaling ko04724 Glutamatergic synapse ko04725 Cholinergic synapse ko04726 Serotonergic synapse ko04728 Dopaminergic synapse ko04730 Long-term depression ko04750 Inflammatory mediator regulation of TRP channels ko04911 Insulin secretion ko04912 GnRH signaling pathway ko04915 Estrogen signaling pathway ko04916 Melanogenesis ko04918 Thyroid hormone synthesis ko04919 Thyroid hormone signaling pathway ko04921 Oxytocin signaling pathway ko04922 Glucagon signaling pathway ko04924 Renin secretion ko04925 Aldosterone synthesis and secretion ko04926 Relaxin signaling pathway ko04933 AGE-RAGE signaling pathway in diabetic complications ko04961 Endocrine and other factor-regulated calcium reabsorption ko04970 Salivary secretion ko04971 Gastric acid secretion ko04972 Pancreatic secretion ko05010 Alzheimer's disease ko05016 Huntington's disease ko05142 Chagas disease (American trypanosomiasis) ko05143 African trypanosomiasis ko05146 Amoebiasis ko05200 Pathways in cancer Phospholipase C I Lipid transport and metabolism ; IPR000909 [Phosphatidylinositol-specific phospholipase C, X domain] ; IPR001711[Phospholipase C, phosphatidylinositol-specific, Y domain] ; IPR009535[Phospholipase C-beta, conserved site] ; IPR014815[Phospholipase C-beta, C-terminal domain] ; IPR015359[Phosphoinositide-specific phospholipase C, EF-hand-like domain] -- -- Q9CPT4 Myeloid-derived growth factor Mydgf 2464.5 2415.1 1962.8 2064.4 2034.7 1976.9 1.12613561553654 0.189266909764026 0.171380575269663 Nonsignificant None -- -- -- -- -- -- -- -- IPR018887 [Myeloid-derived growth factor] -- -- E9QMV2 Costars family protein ABRACL Abracl 605.1 648.4 633.9 674.9 738.6 673.7 0.904273668072058 0.0557106146040146 -0.145168641029456 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR027817 [Costars domain] -- -- Q3UJM9 IRF tryptophan pentad repeat domain-containing protein Irf3 1670.8 1662.2 1789.5 1737.7 1727.6 1741.9 0.983734060531572 0.563447343890948 -0.0236597401029239 Nonsignificant None 1 Molecular Function:regulatory region DNA binding (GO:0000975) interferon regulatory factor 3 -- ko04620 Toll-like receptor signaling pathway ko04621 NOD-like receptor signaling pathway ko04622 RIG-I-like receptor signaling pathway ko04623 Cytosolic DNA-sensing pathway ko05133 Pertussis ko05160 Hepatitis C ko05161 Hepatitis B ko05162 Measles ko05164 Influenza A ko05165 Human papillomavirus infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis -- -- -- IPR001346 [Interferon regulatory factor DNA-binding domain] ; IPR019471[Interferon regulatory factor-3] -- IRF B0QZN5 Vesicle-associated membrane protein 2 Vamp2 372.6 364.1 352.5 335.6 357.3 366.8 1.02783806737756 0.418671877728989 0.0396129904137141 Nonsignificant None 2 Cellular Component:integral component of membrane (GO:0016021),Biological Process:vesicle-mediated transport (GO:0016192) vesicle-associated membrane protein 2 -- ko04130 SNARE interactions in vesicular transport ko04721 Synaptic vesicle cycle ko04911 Insulin secretion ko04962 Vasopressin-regulated water reabsorption ko04970 Salivary secretion Synaptobrevin/VAMP-like protein U Intracellular trafficking, secretion, and vesicular transport ; IPR001388 [Synaptobrevin] -- -- B8X349 JNK-interacting leucine zipper protein long form Spag9 682.8 686.2 691 666.8 671.6 652 1.03496784565916 0.0218132017076081 0.0495859468273402 Nonsignificant None -- -- c-Jun-amino-terminal kinase-interacting protein 4 -- -- JNK/SAPK-associated protein-1 T Signal transduction mechanisms ; IPR019143 [JNK/Rab-associated protein-1, N-terminal] ; IPR032486[JNK-interacting protein, leucine zipper II] -- -- Q9D8L3 Translocon-associated protein subunit delta Ssr4 1654.6 1711 1549.1 1439.5 1442 1432.2 1.13932355054825 0.051272152115417 0.188177508666114 Nonsignificant None 2 Cellular Component:endoplasmic reticulum (GO:0005783),Cellular Component:integral component of membrane (GO:0016021) translocon-associated protein subunit delta -- ko04141 Protein processing in endoplasmic reticulum Translocon-associated complex TRAP, delta subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR008855 [Translocon-associated] -- -- B9EKC3 Rho GTPase activating protein 5 Arhgap5 1425.6 1418.3 1489.7 1445.4 1381.9 1430.7 1.01775481446689 0.444122194320324 0.0253900461313962 Nonsignificant None 3 Molecular Function:GTP binding (GO:0005525),Biological Process:signal transduction (GO:0007165),Biological Process:small GTPase mediated signal transduction (GO:0007264) Rho GTPase-activating protein 5 -- ko04510 Focal adhesion ko04670 Leukocyte transendothelial migration Rho-GTPase activating protein T Signal transduction mechanisms ; IPR000198 [Rho GTPase-activating protein domain] ; IPR001806[Small GTPase superfamily] ; IPR002713[FF domain] ; IPR032835[Rho GTPase-activating protein, FF domain] -- -- Q8BG95 Protein phosphatase 1 regulatory subunit 12B Ppp1r12b 318.2 392 453.6 467.1 412 405 0.906315707499416 0.411614632227074 -0.141914406310063 Nonsignificant None 1 Molecular Function:protein kinase binding (GO:0019901) protein phosphatase 1 regulatory subunit 12B -- ko04270 Vascular smooth muscle contraction ko04510 Focal adhesion ko04810 Regulation of actin cytoskeleton ko04921 Oxytocin signaling pathway ko05205 Proteoglycans in cancer Myosin phosphatase, regulatory subunit OT Posttranslational modification, protein turnover, chaperones ; Signal transduction mechanisms ; IPR020683 [Ankyrin repeat-containing domain] ; IPR031775[cGMP-dependent protein kinase, interacting domain] -- -- A0A2I3BQE0 Non-specific serine/threonine protein kinase Stk3 326.3 312.1 287.7 262.8 269.2 265.3 1.16154521510097 0.0198095606045487 0.216045314570565 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) serine/threonine kinase 3 -- ko04010 MAPK signaling pathway ko04390 Hippo signaling pathway ko04392 Hippo signaling pathway - multiple species STE20-like serine/threonine kinase MST T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR024205[Mst1 SARAH domain] -- -- Q5KU39 Vacuolar protein sorting-associated protein 41 homolog Vps41 356.8 336.4 369.8 399.7 403.7 417.9 0.870384017031033 0.00917149056765248 -0.200276030442699 Nonsignificant None 2 Biological Process:intracellular protein transport (GO:0006886),Biological Process:vesicle-mediated transport (GO:0016192) vacuolar protein sorting-associated protein 41 -- Vacuolar assembly/sorting protein VPS41 U Intracellular trafficking, secretion, and vesicular transport ; IPR000547 [Clathrin, heavy chain/VPS, 7-fold repeat] -- -- Q8BVF2 Phosducin-like protein 3 Pdcl3 1034.7 1036.9 1054.8 1117.8 1136 1089.4 0.935151950227327 0.0084947949166497 -0.0967272913540239 Nonsignificant None -- -- -- -- -- Conserved phosducin-like protein T Signal transduction mechanisms ; IPR024253 [Phosducin, thioredoxin-like domain] -- -- Q8BVD5 MAGUK p55 subfamily member 7 Mpp7 1325.6 1238.2 1133.6 1351.2 1441.3 1289.7 0.905737102542747 0.144432922650407 -0.142835737659088 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Calcium/calmodulin-dependent serine protein kinase/membrane-associated guanylate kinase T Signal transduction mechanisms ; IPR001478 [PDZ domain] ; IPR008145[Guanylate kinase/L-type calcium channel beta subunit] ; IPR011511[Variant SH3 domain] ; IPR014775[L27 domain, C-terminal] -- -- Q9QZH6 Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial Ecsit 405.7 400.2 455.8 458.7 450.8 457.8 0.922767497988737 0.182674086133267 -0.11596090503666 Nonsignificant None -- -- evolutionarily conserved signaling intermediate in Toll pathway -- ko04010 MAPK signaling pathway Intermediate in Toll signal transduction pathway (ECSIT) T Signal transduction mechanisms ; IPR010418 [ECSIT] ; IPR029342[ECSIT, C-terminal domain] -- -- A0A571BEC9 Perilipin-4 Plin4 772.5 775.2 870.4 884.5 837.8 843 0.942618797021791 0.238231424867544 -0.085253644066951 Nonsignificant None -- -- perilipin-4 -- ko03320 PPAR signaling pathway -- -- -- IPR004279 [Perilipin] -- -- Q05C51 Ribonuclease Rnaseh2a 1033.6 1152.1 1063.3 965.9 928.3 1000.2 1.12251243781095 0.0455514311062261 0.166731430595605 Nonsignificant None -- -- ribonuclease H2 subunit A 3.1.26.4 ko03030 DNA replication Ribonuclease HI L Replication, recombination and repair ; IPR024567 [Ribonuclease HII/HIII domain] -- -- Q8JZY2 COMM domain-containing protein 10 Commd10 998.3 995.4 1318 1452 1383 1383.4 0.785060686516215 0.0508198799160755 -0.349123913810562 Nonsignificant None -- -- -- -- -- -- -- -- IPR017920 [COMM domain] -- -- Q3TQY2 Uncharacterized protein Dctn4 1359.6 1324.2 1308.9 1199.4 1261.3 1214.2 1.08647854363384 0.0114869465489354 0.11965968367823 Nonsignificant None 1 Cellular Component:dynactin complex (GO:0005869) dynactin 4 -- ko04962 Vasopressin-regulated water reabsorption ko05016 Huntington's disease Dynactin, subunit p62 N Cell motility ; IPR008603 [Dynactin subunit 4] -- -- Q5DU30 Apoptotic protease-activating factor 1 (Fragment) Apaf1 862.5 911.7 918 860.3 927 889.1 1.00590345239874 0.849890370502794 0.00849184050142957 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Biological Process:regulation of apoptotic process (GO:0042981),Molecular Function:ADP binding (GO:0043531) apoptotic protease-activating factor -- ko01524 Platinum drug resistance ko04115 p53 signaling pathway ko04210 Apoptosis ko04215 Apoptosis - multiple species ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05014 Amyotrophic lateral sclerosis (ALS) ko05016 Huntington's disease ko05134 Legionellosis ko05152 Tuberculosis ko05161 Hepatitis B ko05200 Pathways in cancer ko05222 Small cell lung cancer FOG: WD40 repeat R General function prediction only ; IPR001315 [CARD domain] ; IPR001680[WD40 repeat] ; IPR002182[NB-ARC] ; IPR024977[Anaphase-promoting complex subunit 4, WD40 domain] -- -- Q9CYH2 Peroxiredoxin-like 2A Prxl2a 1347.1 1359.6 1453.7 1552.3 1461.2 1508.3 0.920076075898978 0.0477870471391205 -0.120174940473604 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR032801 [Peroxiredoxin-like FAM213/AAED1] -- -- Q3TXN0 PDZ domain-containing protein (Fragment) Htra2 650.7 648.2 735.5 759.2 799.7 690.5 0.904418956166089 0.170008979046444 -0.14493686431914 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) HtrA serine peptidase 2 3.4.21.108 ko04210 Apoptosis ko04215 Apoptosis - multiple species ko05012 Parkinson's disease Serine protease O Posttranslational modification, protein turnover, chaperones ; IPR001478 [PDZ domain] -- -- Q8BGR9 Ubiquitin-like domain-containing CTD phosphatase 1 Ublcp1 1737.8 1676.9 1679.8 1628.8 1637.4 1719.6 1.02180191744555 0.360072544556234 0.0311155481183876 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) ubiquitin-like domain-containing CTD phosphatase 1 3.1.3.16 -- TFIIF-interacting CTD phosphatase, including NLI-interacting factor (involved in RNA polymerase II regulation) K Transcription ; IPR000626 [Ubiquitin domain] ; IPR004274[FCP1 homology domain] -- -- Q9JK38 Glucosamine 6-phosphate N-acetyltransferase Gnpnat1 697 605.1 613.5 675.7 720 729.4 0.901416403933933 0.106843082506107 -0.149734390497726 Nonsignificant None 1 Molecular Function:N-acetyltransferase activity (GO:0008080) glucosamine-phosphate N-acetyltransferase 2.3.1.4 ko00520 Amino sugar and nucleotide sugar metabolism Glucosamine-phosphate N-acetyltransferase M Cell wall/membrane/envelope biogenesis ; IPR000182 [GNAT domain] -- -- Q61733 28S ribosomal protein S31, mitochondrial Mrps31 1390.6 1309.3 1263.3 1282 1330.5 1290.6 1.01539801696088 0.643625804205379 0.0220453476466867 Nonsignificant None 2 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:mitochondrial small ribosomal subunit (GO:0005763) small subunit ribosomal protein S31 -- -- -- -- -- IPR026299 [Mitochondrial 28S ribosomal protein S31] -- -- A0A1L1SVK0 Platelet-activating factor acetylhydrolase IB subunit alpha2 (Fragment) Pafah1b2 1453.8 1468.1 1773.8 1730.2 1727.8 1685.3 0.912974160558396 0.288114840714676 -0.131354065961318 Nonsignificant None -- -- platelet-activating factor acetylhydrolase IB subunit beta/gamma 3.1.1.47 ko00565 Ether lipid metabolism ko01100 Metabolic pathways Attractin and platelet-activating factor acetylhydrolase TV Signal transduction mechanisms ; Defense mechanisms ; IPR013830 [SGNH hydrolase-type esterase domain] -- -- P06800 Receptor-type tyrosine-protein phosphatase C Ptprc 964.1 1144.9 903.1 736.8 842.7 799 1.26638637796931 0.0552859409526754 0.340717642156097 Nonsignificant None 3 Molecular Function:protein tyrosine phosphatase activity (GO:0004725),Biological Process:protein dephosphorylation (GO:0006470),Biological Process:T cell receptor signaling pathway (GO:0050852) receptor-type tyrosine-protein phosphatase C 3.1.3.48 ko04514 Cell adhesion molecules (CAMs) ko04660 T cell receptor signaling pathway ko04666 Fc gamma R-mediated phagocytosis ko05340 Primary immunodeficiency Protein tyrosine phosphatase T Signal transduction mechanisms ; IPR000242 [PTP type protein phosphatase] ; IPR016335[Receptor-type tyrosine-protein phosphatase C] ; IPR024739[Protein tyrosine phosphatase, receptor type, N-terminal] -- -- Q8R5C0 Metaxin Mtx1 1029.1 1047.8 1378.7 1596.1 1521 1470.3 0.753280725465405 0.0340905502449616 -0.408740479974994 Nonsignificant None 2 Cellular Component:mitochondrial outer membrane (GO:0005741),Biological Process:protein targeting to mitochondrion (GO:0006626) metaxin -- -- Translocase of outer mitochondrial membrane complex, subunit TOM37/Metaxin 1 U Intracellular trafficking, secretion, and vesicular transport ; IPR019564 [Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain] ; IPR033468[Metaxin, glutathione S-transferase domain] -- -- B1ARW4 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 (Fragment) Ndufs5 1139.1 1247.9 1431.2 1738.1 1589.8 1701.3 0.759206235584188 0.0137328245617912 -0.397436253200835 Nonsignificant None -- -- NADH dehydrogenase (ubiquinone) Fe-S protein 5 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease NADH:ubiquinone oxidoreductase, NDUFS5/15kDa C Energy production and conversion ; IPR019342 [NADH:ubiquinone oxidoreductase, iron-sulphur subunit 5] -- -- A2AVR6 Acyl-coenzyme A thioesterase 11 Acot11 1407.3 1473.2 1527.6 1467.4 1506.4 1462.5 0.993643351441516 0.814184818932856 -0.00919997693953948 Nonsignificant None 1 Molecular Function:lipid binding (GO:0008289) acyl-CoA thioesteraes 11 3.1.2.- -- Acyl-CoA thioesterase I Lipid transport and metabolism ; IPR002913 [START domain] ; IPR006683[Thioesterase domain] -- -- Q6NZN0 RNA-binding protein 26 Rbm26 1105.3 1119.3 1045.4 932.6 945.6 923.9 1.16698190642732 0.00268481704177847 0.222782192827665 Nonsignificant None 1 Biological Process:mRNA processing (GO:0006397) RNA-binding protein 26 -- -- Proteins containing the RNA recognition motif R General function prediction only ; IPR002483 [PWI domain] -- -- P35385 Heat shock protein beta-7 Hspb7 1018.8 1076.2 998.2 1063.4 1125 1024.1 0.962863813229572 0.348816829646821 -0.0545963361461325 Nonsignificant None -- -- heat shock protein beta-7 -- -- Alpha crystallins O Posttranslational modification, protein turnover, chaperones ; IPR002068 [Alpha crystallin/Hsp20 domain] -- -- P42232 Signal transducer and activator of transcription 5B Stat5b 122 125.7 142.9 138.4 134.3 150.2 0.923622605816978 0.250126875457588 -0.11462461114201 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Biological Process:signal transduction (GO:0007165) signal transducer and activator of transcription 5B -- ko04012 ErbB signaling pathway ko04062 Chemokine signaling pathway ko04217 Necroptosis ko04630 Jak-STAT signaling pathway ko04658 Th1 and Th2 cell differentiation ko04659 Th17 cell differentiation ko04917 Prolactin signaling pathway ko04933 AGE-RAGE signaling pathway in diabetic complications ko05161 Hepatitis B ko05162 Measles ko05166 HTLV-I infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05220 Chronic myeloid leukemia ko05221 Acute myeloid leukemia ko05223 Non-small cell lung cancer STAT protein KT Transcription ; Signal transduction mechanisms ; IPR000980 [SH2 domain] ; IPR013799[STAT transcription factor, protein interaction] ; IPR013800[STAT transcription factor, all-alpha domain] ; IPR013801[STAT transcription factor, DNA-binding] -- STAT Q9D7V1 SH2 domain-containing protein 4A Sh2d4a 898.2 867.1 885.5 749.2 825.4 797.1 1.11767930176667 0.017898334932719 0.16050629182874 Nonsignificant None -- -- SH2 domain-containing protein 4A -- -- -- -- -- IPR000980 [SH2 domain] -- -- Q8BSQ9 Protein polybromo-1 Pbrm1 1078.9 1089.5 1211.9 1099.2 1128.7 1116.5 1.01073436191843 0.796986123959366 0.0154038824052943 Nonsignificant None 2 Molecular Function:chromatin binding (GO:0003682),Molecular Function:protein binding (GO:0005515) protein polybromo-1 -- ko05225 Hepatocellular carcinoma Chromatin remodeling complex RSC, subunit RSC1/Polybromo and related proteins BK Chromatin structure and dynamics ; Transcription ; IPR001025 [Bromo adjacent homology (BAH) domain] ; IPR001487[Bromodomain] ; IPR009071[High mobility group box domain] -- HMG Q9WUU7 Cathepsin Z Ctsz 1521.1 1664.8 1404.3 1411.3 1425.3 1475.2 1.06456700218006 0.298807098802522 0.0902667536144547 Nonsignificant None 2 Biological Process:proteolysis (GO:0006508),Molecular Function:cysteine-type peptidase activity (GO:0008234) cathepsin X 3.4.18.1 ko04142 Lysosome ko04210 Apoptosis Cysteine proteinase Cathepsin L O Posttranslational modification, protein turnover, chaperones ; IPR000668 [Peptidase C1A, papain C-terminal] -- -- Q9ER41 Torsin-1B Tor1b 558.9 545.6 536.6 569.7 594.9 563.4 0.949710648148148 0.0669748896509261 -0.074440065725632 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) -- -- -- ATPase of the AAA+ superfamily R General function prediction only ; IPR010448 [Torsin] -- -- Q91XL1 Leucine-rich HEV glycoprotein Lrg1 1290.4 1227.1 860.5 365.9 407 406.7 2.86368260427263 0.030745900406066 1.51787160062701 Significant up 1 Molecular Function:protein binding (GO:0005515) -- -- -- FOG: Leucine rich repeat R General function prediction only ; IPR000483 [Cysteine-rich flanking region, C-terminal] ; IPR001611[Leucine-rich repeat] -- -- P53995 Anaphase-promoting complex subunit 1 Anapc1 915.7 891.7 803.1 838.5 863.3 815.4 1.0370649928492 0.447109556741028 0.0525063106632391 Nonsignificant None 1 Cellular Component:anaphase-promoting complex (GO:0005680) anaphase-promoting complex subunit 1 -- ko04110 Cell cycle ko04114 Oocyte meiosis ko04120 Ubiquitin mediated proteolysis ko04914 Progesterone-mediated oocyte maturation ko05166 HTLV-I infection Anaphase-promoting complex (APC), subunit 1 (meiotic check point regulator/Tsg24) DO Cell cycle control, cell division, chromosome partitioning ; Posttranslational modification, protein turnover, chaperones ; IPR002015 [Proteasome/cyclosome repeat] ; IPR024990[Anaphase-promoting complex subunit 1] -- -- Q3UWG5 Tetraspanin Cd81 428.6 399 488.5 532 491.1 504.3 0.86166033782899 0.0717718090527554 -0.214808816640825 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) CD81 antigen -- ko04662 B cell receptor signaling pathway ko05144 Malaria ko05160 Hepatitis C Tetraspanin family integral membrane protein R General function prediction only ; IPR018499 [Tetraspanin/Peripherin] -- -- Q9CWL8 Beta-catenin-like protein 1 Ctnnbl1 2138.5 2167.1 2089.2 1772.5 1817.8 1858.8 1.17355159567635 0.000731163117150052 0.230881271933563 Nonsignificant None -- -- beta-catenin-like protein 1 -- ko03040 Spliceosome Uncharacterized conserved protein S Function unknown ; IPR013180 [Beta-catenin-like protein 1, N-terminal] -- -- Q9CQ89 Protein CutA Cuta 344.3 362.5 355 406 448.8 412.6 0.837778128451949 0.0087243731373755 -0.255359874070119 Nonsignificant None 1 Biological Process:response to metal ion (GO:0010038) periplasmic divalent cation tolerance protein -- -- Divalent cation tolerance-related protein P Inorganic ion transport and metabolism ; IPR004323 [Divalent ion tolerance protein, CutA] -- -- Q9D104 Signal recognition particle 19 kDa protein Srp19 820.7 807.6 1003.4 912.6 936.8 963.3 0.935649020514097 0.404986929870506 -0.0959606455528011 Nonsignificant None 3 Biological Process:SRP-dependent cotranslational protein targeting to membrane (GO:0006614),Molecular Function:7S RNA binding (GO:0008312),Cellular Component:signal recognition particle (GO:0048500) signal recognition particle subunit SRP19 -- ko03060 Protein export Signal recognition particle, subunit Srp19 U Intracellular trafficking, secretion, and vesicular transport ; IPR002778 [Signal recognition particle, SRP19 subunit] -- -- P08905 Lysozyme C-2 Lyz2 1800.7 2979.8 1735.6 700.9 743.2 715.7 3.01699231410316 0.0694040846698107 1.59311102117159 Nonsignificant None -- -- lysozyme C 3.2.1.17 ko04970 Salivary secretion -- -- -- IPR001916 [Glycoside hydrolase, family 22] -- -- A0A0A6YWN9 Ubiquitin carboxyl-terminal hydrolase (Fragment) Usp19 556 537.2 542.4 497.2 501.4 502.2 1.08981876332623 0.00151064796872375 0.124088235010989 Nonsignificant None 2 Biological Process:protein deubiquitination (GO:0016579),Molecular Function:thiol-dependent ubiquitinyl hydrolase activity (GO:0036459) ubiquitin carboxyl-terminal hydrolase 19 3.4.19.12 -- Ubiquitin C-terminal hydrolase O Posttranslational modification, protein turnover, chaperones ; IPR001394 [Peptidase C19, ubiquitin carboxyl-terminal hydrolase] ; IPR002893[Zinc finger, MYND-type] ; IPR007052[CS domain] -- -- P01865 Ig gamma-2A chain C region, membrane-bound form Igh-1a 159.4 164.5 178.6 377.7 422.3 437.7 0.405994990708572 0.000203473782357516 -1.30046616778352 Significant down -- -- immunoglobulin lambda-like polypeptide 1 -- -- -- -- -- IPR003597 [Immunoglobulin C1-set] -- -- O55201 Transcription elongation factor SPT5 Supt5h 1759 1679.4 1660.3 1596.1 1556.1 1689.8 1.05301528294093 0.161095169478132 0.0745263750750189 Nonsignificant None -- -- transcription elongation factor SPT5 -- -- RNA polymerase II transcription elongation factor DSIF/SUPT5H/SPT5 K Transcription ; IPR005100 [Transcription elongation factor Spt5, NGN domain] ; IPR005824[KOW] ; IPR022581[Spt5 transcription elongation factor, N-terminal] -- -- Q9CYN9 Renin receptor Atp6ap2 538 471.3 466.5 533 557.9 547.3 0.900866805029911 0.0887113614146791 -0.150614278446461 Nonsignificant None 2 Molecular Function:receptor activity (GO:0004872),Cellular Component:integral component of membrane (GO:0016021) renin receptor -- ko04614 Renin-angiotensin system ATPase membrane sector associated protein C Energy production and conversion ; IPR012493 [Renin receptor-like] -- -- Q3THC1 26S proteasome non-ATPase regulatory subunit 9 Psmd9 882.2 897.6 833.1 898 912.5 874.2 0.973255857265244 0.345984670320849 -0.039108972836414 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) 26S proteasome non-ATPase regulatory subunit 9 -- -- 26S proteasome regulatory complex, subunit PSMD9 O Posttranslational modification, protein turnover, chaperones ; IPR001478 [PDZ domain] -- -- Q8CGL5 Stefin A1 Cstdc6 140.6 160 97.5 84.7 85 74.3 1.63155737704918 0.0523324753671631 0.706249723641101 Nonsignificant None 1 Molecular Function:cysteine-type endopeptidase inhibitor activity (GO:0004869) -- -- -- -- -- -- IPR000010 [Cystatin domain] -- -- A0A5F8MP96 Septin-4 Septin4 642.4 632.7 691.8 693.4 711 712.6 0.929097779877185 0.0605725016372436 -0.106097658537122 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) septin 4 -- ko04210 Apoptosis ko04215 Apoptosis - multiple species Septin family protein (P-loop GTPase) DZU Cell cycle control, cell division, chromosome partitioning ; Cytoskeleton ; Intracellular trafficking, secretion, and vesicular transport ; IPR027979 [Protein of unknown function DUF4655] ; IPR030379[Septin-type guanine nucleotide-binding (G) domain] -- -- P34914 Bifunctional epoxide hydrolase 2 Ephx2 874.4 656.3 605.6 694.2 695.7 889.8 0.937096986445585 0.672460399784672 -0.0937297250999081 Nonsignificant None -- -- -- -- ko00590 Arachidonic acid metabolism ko01100 Metabolic pathways ko04146 Peroxisome Soluble epoxide hydrolase I Lipid transport and metabolism ; IPR000073 [Alpha/beta hydrolase fold-1] ; IPR023214[HAD-like domain] -- -- Q8VD75 Huntingtin-interacting protein 1 Hip1 508.8 468.1 464.9 473 499.6 495.8 0.981885044946881 0.617254635831826 -0.026373965248525 Nonsignificant None 2 Molecular Function:actin binding (GO:0003779),Molecular Function:phospholipid binding (GO:0005543) huntingtin interacting protein 1 -- ko05016 Huntington's disease Actin-binding protein SLA2/Huntingtin-interacting protein Hip1 Z Cytoskeleton ; IPR002558 [I/LWEQ domain] ; IPR011417[AP180 N-terminal homology (ANTH) domain] ; IPR032422[Huntingtin-interacting protein 1, clathrin-binding domain] -- -- Q3TAH3 Nucleoplasmin domain-containing protein Npm3 579 590.2 502.2 544.4 506.6 505 1.07416452442159 0.275863463401746 0.103214980649859 Nonsignificant None -- -- nucleophosmin 3 -- -- -- -- -- IPR024057 [Nucleoplasmin core domain] -- -- Q9ESW4 Acylglycerol kinase, mitochondrial Agk 1599.4 1697.6 1796.9 2019.8 1918.2 1989.6 0.859352857817667 0.012548669887222 -0.218677458639047 Nonsignificant None 1 Molecular Function:kinase activity (GO:0016301) acylglycerol kinase 2.7.1.94 ko00561 Glycerolipid metabolism ko01100 Metabolic pathways Predicted lipid kinase IT Lipid transport and metabolism ; Signal transduction mechanisms ; IPR001206 [Diacylglycerol kinase, catalytic domain] -- -- Q8BYN3 Inositol-tetrakisphosphate 1-kinase Itpk1 660.8 607.9 656.7 504.5 600.4 573.6 1.14709562109026 0.0685017639382016 0.197985658418051 Nonsignificant None 7 Molecular Function:magnesium ion binding (GO:0000287),Molecular Function:ATP binding (GO:0005524),Cellular Component:intracellular (GO:0005622),Biological Process:inositol trisphosphate metabolic process (GO:0032957),Molecular Function:inositol tetrakisphosphate 1-kinase activity (GO:0047325),Molecular Function:inositol-1,3,4-trisphosphate 6-kinase activity (GO:0052725),Molecular Function:inositol-1,3,4-trisphosphate 5-kinase activity (GO:0052726) -- -- ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system -- -- -- IPR008656 [Inositol-tetrakisphosphate 1-kinase] -- -- E9Q3I4 Intersectin-1 Itsn1 1007.9 1097.5 1248.8 1256.8 1290.2 1157.1 0.905537107529494 0.222706250662754 -0.143154333058272 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) intersectin -- -- Endocytic adaptor protein intersectin TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR000261 [EH domain] ; IPR001452[SH3 domain] -- -- Q99LE6 ATP-binding cassette sub-family F member 2 Abcf2 922.5 787.3 775.9 662.3 662.4 707.4 1.22321736135033 0.0376740795171247 0.29068078839431 Nonsignificant None 2 Molecular Function:ATP binding (GO:0005524),Molecular Function:ATPase activity (GO:0016887) ATP-binding cassette, subfamily F, member 2 -- -- Predicted transporter (ABC superfamily) R General function prediction only ; IPR003439 [ABC transporter-like] ; IPR032781[ABC-transporter extension domain] -- -- O88271 Craniofacial development protein 1 Cfdp1 932.9 942.7 892.9 757.9 809.4 787.1 1.1758834522596 0.00293036557015202 0.233745074477363 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein BCNT S Function unknown ; IPR011421 [BCNT-C domain] -- -- A0A0R4IZY6 Myeloblastin Prtn3 321.2 471.9 289.9 283.9 277.3 258.9 1.32057066211438 0.257958533467069 0.401161500410341 Nonsignificant None 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) myeloblastin 3.4.21.76 -- Trypsin E Amino acid transport and metabolism ; IPR001254 [Serine proteases, trypsin domain] -- -- A0A494B9F0 E3 ubiquitin-protein ligase Nedd4l 417.7 438.4 427.2 475.4 436.3 477.9 0.923503166378814 0.0740183068362165 -0.114811187159691 Nonsignificant None 2 Molecular Function:ubiquitin-protein transferase activity (GO:0004842),Molecular Function:protein binding (GO:0005515) E3 ubiquitin-protein ligase NEDD4-like 2.3.2.26 ko04120 Ubiquitin mediated proteolysis ko04144 Endocytosis ko04530 Tight junction ko04960 Aldosterone-regulated sodium reabsorption Ubiquitin protein ligase RSP5/NEDD4 O Posttranslational modification, protein turnover, chaperones ; IPR000008 [C2 domain] ; IPR000569[HECT domain] ; IPR001202[WW domain] -- -- Q9R061 Cytosolic Fe-S cluster assembly factor NUBP2 Nubp2 1161.4 1145.9 1136.4 1076.5 1123.3 1017.6 1.07033629638839 0.0743868218102844 0.0980641582188111 Nonsignificant None -- -- -- -- -- Predicted ATPase, nucleotide-binding D Cell cycle control, cell division, chromosome partitioning ; IPR033756 [Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35] -- -- Q3TDD9 Protein phosphatase 1 regulatory subunit 21 Ppp1r21 540.3 566.6 597.6 542.4 589.2 514.3 1.03560362111914 0.515470064671408 0.0504719149253031 Nonsignificant None -- -- protein phosphatase 1 regulatory subunit 21 -- -- Uncharacterized conserved protein S Function unknown ; IPR019343 [Uncharacterised domain KLRAQ/TTKRSYEDQ, N-terminal] ; IPR019348[Uncharacterised domain KLRAQ/TTKRSYEDQ, C-terminal] -- -- Q8BRK8 5-AMP-activated protein kinase catalytic subunit alpha-2 Prkaa2 578.4 581.9 618.7 655 686.3 664.2 0.887060583395662 0.00895626497243308 -0.172895455547349 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) 5'-AMP-activated protein kinase, catalytic alpha subunit 2.7.11.11 ko04068 FoxO signaling pathway ko04140 Autophagy - animal ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04152 AMPK signaling pathway ko04211 Longevity regulating pathway ko04213 Longevity regulating pathway - multiple species ko04371 Apelin signaling pathway ko04530 Tight junction ko04710 Circadian rhythm ko04910 Insulin signaling pathway ko04920 Adipocytokine signaling pathway ko04921 Oxytocin signaling pathway ko04922 Glucagon signaling pathway ko04931 Insulin resistance ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05410 Hypertrophic cardiomyopathy (HCM) ko05418 Fluid shear stress and atherosclerosis Serine/threonine protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR032270[AMPK, C-terminal adenylate sensor domain] -- -- Q6P8I4 PEST proteolytic signal-containing nuclear protein Pcnp 2356 2422.4 2018.9 2110.4 2125.8 2138 1.06637695710834 0.376055059814287 0.0927175112853086 Nonsignificant None 1 Biological Process:protein ubiquitination (GO:0016567) -- -- -- -- -- -- IPR029169 [PEST proteolytic signal-containing nuclear protein] -- -- A0A345IT93 Envelope polyprotein (Fragment) env 1205.1 1287.8 1315.2 1185.1 1374.9 1170.4 1.02082886553721 0.743002561116322 0.0297410292571516 Nonsignificant None -- -- -- -- -- -- -- -- IPR018154 [TLV/ENV coat polyprotein] -- -- Q3UWL8 Prefoldin subunit 4 Pfdn4 1882.2 2028.8 1917 1665.1 1719.1 1686.9 1.1492575575319 0.00578011678984481 0.200702153366323 Nonsignificant None 3 Biological Process:protein folding (GO:0006457),Cellular Component:prefoldin complex (GO:0016272),Molecular Function:unfolded protein binding (GO:0051082) prefoldin subunit 4 -- -- Molecular chaperone Prefoldin, subunit 4 O Posttranslational modification, protein turnover, chaperones ; IPR002777 [Prefoldin beta-like] -- -- Q8R010 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 Aimp2 1411.3 1342.9 1473.5 1528.1 1536.2 1511.7 0.92388548951049 0.0390235512954233 -0.11421404622543 Nonsignificant None -- -- aminoacyl tRNA synthase complex-interacting multifunctional protein 2 -- -- -- -- -- IPR004046 [Glutathione S-transferase, C-terminal] ; IPR031889[AIMP2, lysyl-tRNA synthetase binding domain] -- -- Q9EQG9 Ceramide transfer protein Cert1 1237.7 1220.3 1332.6 1372.6 1385.9 1336.4 0.925688050990256 0.055445782727594 -0.111401995475185 Nonsignificant None 1 Molecular Function:lipid binding (GO:0008289) collagen type IV alpha-3-binding protein -- -- Serine/threonine protein kinase GPBP TV Signal transduction mechanisms ; Defense mechanisms ; IPR001849 [Pleckstrin homology domain] ; IPR002913[START domain] -- -- A0A0U1RPA0 Pleckstrin homology domain-containing family A member 7 (Fragment) Plekha7 916.3 904.3 928.4 963.7 936.6 944.6 0.966290555028296 0.0396733929853232 -0.0494710349464955 Nonsignificant None -- -- -- -- -- -- -- -- IPR001849 [Pleckstrin homology domain] -- -- Q8CI37 Phosphoenolpyruvate carboxykinase (GTP) Pck1 433 390.8 462.1 637.4 568.2 599.9 0.712212683467184 0.00384088447502082 -0.489619966667049 Nonsignificant None 3 Molecular Function:phosphoenolpyruvate carboxykinase activity (GO:0004611),Molecular Function:GTP binding (GO:0005525),Biological Process:gluconeogenesis (GO:0006094) phosphoenolpyruvate carboxykinase (GTP) 4.1.1.32 ko00010 Glycolysis / Gluconeogenesis ko00020 Citrate cycle (TCA cycle) ko00620 Pyruvate metabolism ko01100 Metabolic pathways ko03320 PPAR signaling pathway ko04068 FoxO signaling pathway ko04151 PI3K-Akt signaling pathway ko04152 AMPK signaling pathway ko04910 Insulin signaling pathway ko04920 Adipocytokine signaling pathway ko04922 Glucagon signaling pathway ko04931 Insulin resistance ko04964 Proximal tubule bicarbonate reclamation Phosphoenolpyruvate carboxykinase C Energy production and conversion ; IPR008209 [Phosphoenolpyruvate carboxykinase, GTP-utilising] -- -- P46412 Glutathione peroxidase 3 Gpx3 2075.8 1847.1 1563.1 1763.6 1748.2 1994 0.996403792364416 0.9705893498977 -0.00519758232615198 Nonsignificant None 3 Molecular Function:glutathione peroxidase activity (GO:0004602),Biological Process:response to oxidative stress (GO:0006979),Biological Process:oxidation-reduction process (GO:0055114) glutathione peroxidase 1.11.1.9 ko00480 Glutathione metabolism ko00590 Arachidonic acid metabolism ko04918 Thyroid hormone synthesis Glutathione peroxidase O Posttranslational modification, protein turnover, chaperones ; IPR000889 [Glutathione peroxidase] -- -- Q7TS64 G protein-coupled receptor kinase Grk2 1180.1 1225.3 1220.5 1251.1 1241.8 1222.6 0.975884806890055 0.146546236534641 -0.0352172322800356 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) beta-adrenergic-receptor kinase 2.7.11.15 ko04062 Chemokine signaling pathway ko04144 Endocytosis ko04340 Hedgehog signaling pathway ko04724 Glutamatergic synapse ko04740 Olfactory transduction ko05032 Morphine addiction G protein-coupled receptor kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR001849[Pleckstrin homology domain] ; IPR016137[RGS domain] -- -- Q3ULK8 Uncharacterized protein Cnbp 1711.6 1526 1230.6 1346.3 1283.2 1300.2 1.13703336132529 0.32797503585743 0.185274584496179 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:zinc ion binding (GO:0008270) cellular nucleic acid-binding protein -- -- E3 ubiquitin ligase interacting with arginine methyltransferase O Posttranslational modification, protein turnover, chaperones ; IPR001878 [Zinc finger, CCHC-type] -- -- Q8WTY4 Anamorsin Ciapin1 2055.9 2075.9 2006 1845.2 1969 1551.9 1.14381021598554 0.109549326071305 0.193847696198387 Nonsignificant None 5 Cellular Component:cytoplasm (GO:0005737),Biological Process:metabolic process (GO:0008152),Molecular Function:methyltransferase activity (GO:0008168),Biological Process:iron-sulfur cluster assembly (GO:0016226),Molecular Function:iron-sulfur cluster binding (GO:0051536) -- -- -- Protein DRE2, required for cell viability S Function unknown ; IPR007785 [Anamorsin] ; IPR013216[Methyltransferase type 11] -- -- Q922R3 Carboxylic ester hydrolase Cel 819.2 706.1 666.8 655.4 1123.5 694 0.886449108334344 0.582729730966224 -0.173890287521101 Nonsignificant None -- -- -- -- ko00100 Steroid biosynthesis ko00561 Glycerolipid metabolism ko01100 Metabolic pathways ko04972 Pancreatic secretion ko04975 Fat digestion and absorption Carboxylesterase and related proteins R General function prediction only ; IPR002018 [Carboxylesterase, type B] -- -- O70325 Phospholipid hydroperoxide glutathione peroxidase Gpx4 2018.2 1967.1 1887.6 1835.8 1707.9 1979.1 1.06339175780401 0.251167756299477 0.088673189455754 Nonsignificant None 3 Molecular Function:glutathione peroxidase activity (GO:0004602),Biological Process:response to oxidative stress (GO:0006979),Biological Process:oxidation-reduction process (GO:0055114) phospholipid-hydroperoxide glutathione peroxidase 1.11.1.12 ko00480 Glutathione metabolism ko04216 Ferroptosis Glutathione peroxidase O Posttranslational modification, protein turnover, chaperones ; IPR000889 [Glutathione peroxidase] -- -- B2RXC1 Trafficking protein particle complex subunit 11 Trappc11 1269.4 1184.1 1277.3 1358.3 1407.1 1379.7 0.90005066222769 0.013879368974724 -0.151921884458878 Nonsignificant None -- -- trafficking protein particle complex subunit 11 -- -- Uncharacterized conserved protein S Function unknown ; IPR021773 [Foie gras liver health family 1] ; IPR025876[Trafficking protein particle complex subunit 11, C-terminal] -- -- B2RQ83 Gem (Nuclear organelle) associated protein 5 Gemin5 600.6 648.3 672.6 551.4 578.9 609.4 1.10450077599586 0.0880047478509111 0.143394432296617 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) gem associated protein 5 -- ko03013 RNA transport -- -- -- IPR001680 [WD40 repeat] ; IPR024977[Anaphase-promoting complex subunit 4, WD40 domain] -- -- Q3TC93 HCLS1-binding protein 3 Hs1bp3 283.3 284.5 351.4 333.4 359.2 361.2 0.872271778326058 0.137570852296406 -0.197150381727364 Nonsignificant None 1 Molecular Function:phosphatidylinositol binding (GO:0035091) -- -- -- -- -- -- IPR001683 [Phox homologous domain] -- -- K7Q751 Non-specific protein-tyrosine kinase Ptk2 474.9 450.6 436.6 402.4 426.9 432.1 1.07983193277311 0.0809926048215809 0.110806785885935 Nonsignificant None 6 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein tyrosine kinase activity (GO:0004713),Molecular Function:signal transducer activity (GO:0004871),Cellular Component:focal adhesion (GO:0005925),Biological Process:protein phosphorylation (GO:0006468),Biological Process:signal complex assembly (GO:0007172) focal adhesion kinase 1 2.7.10.2 ko01522 Endocrine resistance ko04012 ErbB signaling pathway ko04062 Chemokine signaling pathway ko04151 PI3K-Akt signaling pathway ko04360 Axon guidance ko04370 VEGF signaling pathway ko04510 Focal adhesion ko04670 Leukocyte transendothelial migration ko04810 Regulation of actin cytoskeleton ko05100 Bacterial invasion of epithelial cells ko05146 Amoebiasis ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05202 Transcriptional misregulation in cancer ko05205 Proteoglycans in cancer ko05222 Small cell lung cancer ko05418 Fluid shear stress and atherosclerosis Focal adhesion tyrosine kinase FAK, contains FERM domain T Signal transduction mechanisms ; IPR001245 [Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR005189[Focal adhesion kinase, targeting (FAT) domain] ; IPR019748[FERM central domain] -- -- A0A1W2P729 Protein canopy homolog 2 (Fragment) Cnpy2 360.4 327.1 364.9 426.6 435.2 429.7 0.814866434378629 0.00282215908670235 -0.295364489839473 Nonsignificant None -- -- -- -- -- Predicted membrane protein, contains type II SA sequence R General function prediction only ; IPR021852 [Domain of unknown function DUF3456] -- -- P0C605 cGMP-dependent protein kinase 1 Prkg1 1496.3 1478.5 1442.7 1427.7 1420.3 1525.4 1.01008368774866 0.714011065429322 0.0144748285198593 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) cGMP-dependent protein kinase 1 2.7.11.12 ko04022 cGMP-PKG signaling pathway ko04270 Vascular smooth muscle contraction ko04540 Gap junction ko04611 Platelet activation ko04713 Circadian entrainment ko04730 Long-term depression ko04740 Olfactory transduction ko04923 Regulation of lipolysis in adipocytes ko04970 Salivary secretion cGMP-dependent protein kinase T Signal transduction mechanisms ; IPR000595 [Cyclic nucleotide-binding domain] ; IPR000719[Protein kinase domain] ; IPR031831[cGMP-dependent protein kinase, N-terminal coiled-coil domain] -- -- Q9CQJ6 Density-regulated protein Denr 1179.2 1121.9 1175.9 1117.4 1167.5 1152.8 1.01143206213457 0.611214651643028 0.0163994173620766 Nonsignificant None 2 Molecular Function:translation initiation factor activity (GO:0003743),Biological Process:translational initiation (GO:0006413) -- -- -- Density-regulated protein related to translation initiation factor 1 (eIF-1/SUI1) R General function prediction only ; IPR001950 [SUI1 domain] -- -- Q922J3 CAP-Gly domain-containing linker protein 1 Clip1 936.6 987.9 946 964.3 971.9 970.1 0.987681932353852 0.52924826637809 -0.0178815758451836 Nonsignificant None -- -- CAP-Gly domain-containing linker protein 1 -- ko04150 mTOR signaling pathway Cytoskeleton-associated protein and related proteins ZR Cytoskeleton ; General function prediction only ; IPR000938 [CAP Gly-rich domain] ; IPR032108[CLIP1, zinc knuckle] -- -- A0A087WNZ5 Lymphocyte antigen 6C1 Ly6c1 818.9 940.8 663 544 563.6 552.3 1.45954575576842 0.0863795214263619 0.545519439059071 Nonsignificant None -- -- lymphocyte antigen 6 complex locus protein D/E/G6/H -- -- 40S ribosomal protein S28 J Translation, ribosomal structure and biogenesis ; IPR016054 [Ly-6 antigen/uPA receptor-like] -- -- Q6P9J9 Anoctamin-6 Ano6 1252.1 1255.5 1248.5 1288.9 1226.2 1304 0.983503966903197 0.471196031298878 -0.023997223349466 Nonsignificant None 1 Molecular Function:protein dimerization activity (GO:0046983) anoctamin-6 -- -- Uncharacterized conserved protein S Function unknown ; IPR007632 [Anoctamin] ; IPR032394[Anoctamin, dimerisation domain] -- -- Q3TIJ4 RNA 3-terminal-phosphate cyclase (ATP) Rtca 564 533.6 565.7 651.3 586.4 650.2 0.881031834313258 0.0348911035462316 -0.182733945916345 Nonsignificant None -- -- RNA 3'-terminal phosphate cyclase (ATP) 6.5.1.4 -- RNA 3'-terminal phosphate cyclase A RNA processing and modification ; IPR013791 [RNA 3'-terminal phosphate cyclase, insert domain] ; IPR023797[RNA 3'-terminal phosphate cyclase domain] -- -- Q3UIW3 Uncharacterized protein Lamp2 1640.3 1800.7 1826.3 1694.4 1779.7 1735.3 1.01111452374554 0.775313918674193 0.0159464131483714 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) lysosomal-associated membrane protein 1/2 -- ko04140 Autophagy - animal ko04142 Lysosome ko04145 Phagosome ko05152 Tuberculosis Lysosomal-associated membrane protein R General function prediction only ; IPR002000 [Lysosome-associated membrane glycoprotein] -- -- P47968 Ribose-5-phosphate isomerase Rpia 815.3 898.5 883.9 911.2 934.4 903.5 0.944927430795533 0.137976635492793 -0.081724558412416 Nonsignificant None 1 Molecular Function:ribose-5-phosphate isomerase activity (GO:0004751) ribose 5-phosphate isomerase A 5.3.1.6 ko00030 Pentose phosphate pathway ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids Ribose 5-phosphate isomerase G Carbohydrate transport and metabolism ; IPR004788 [Ribose 5-phosphate isomerase, type A] -- -- Q3ULZ3 Phosphoserine aminotransferase Psat1 2381.3 2333.2 1919.2 1330.7 1492.3 1479 1.54200371920037 0.00750824121827723 0.624806244932235 Significant up -- -- phosphoserine aminotransferase 2.6.1.52 ko00260 Glycine, serine and threonine metabolism ko00750 Vitamin B6 metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids Phosphoserine aminotransferase HE Coenzyme transport and metabolism ; Amino acid transport and metabolism ; IPR000192 [Aminotransferase class V domain] -- -- E9Q704 Peptidyl-glycine alpha-amidating monooxygenase Pam 435.2 440 482.2 598.8 633.3 628.3 0.729628036981294 0.000805631586697186 -0.454766926737896 Nonsignificant None 4 Molecular Function:monooxygenase activity (GO:0004497),Molecular Function:copper ion binding (GO:0005507),Molecular Function:protein binding (GO:0005515),Biological Process:oxidation-reduction process (GO:0055114) peptidylglycine monooxygenase 1.14.17.3 -- Peptidylglycine alpha-amidating monooxygenase O Posttranslational modification, protein turnover, chaperones ; IPR000323 [Copper type II, ascorbate-dependent monooxygenase, N-terminal] ; IPR001258[NHL repeat] ; IPR024548[Copper type II ascorbate-dependent monooxygenase, C-terminal] -- -- Q61263 Sterol O-acyltransferase 1 Soat1 510.7 514.1 431.9 441 440.1 475.2 1.07402492074025 0.316100919878733 0.103027468752803 Nonsignificant None -- -- sterol O-acyltransferase 2.3.1.26 ko00100 Steroid biosynthesis ko04979 Cholesterol metabolism Sterol O-acyltransferase/Diacylglycerol O-acyltransferase I Lipid transport and metabolism ; IPR004299 [Membrane bound O-acyl transferase, MBOAT] -- -- Q8C6F9 C-type lectin domain-containing protein (Fragment) Reg1 1469 1060.1 1578.2 448.6 959.6 551.3 2.09609594284256 0.0320643001833998 1.06770475365748 Significant up -- -- -- -- -- C-type lectin TV Signal transduction mechanisms ; Defense mechanisms ; IPR001304 [C-type lectin-like] -- -- Q3UM52 Polypeptide N-acetylgalactosaminyltransferase (Fragment) Galnt2 1030.7 1017.9 1022.6 1033.9 954.6 970 1.03809362852797 0.260324155888883 0.0539365702095732 Nonsignificant None -- -- polypeptide N-acetylgalactosaminyltransferase 2.4.1.41 ko00512 Mucin type O-glycan biosynthesis ko01100 Metabolic pathways Predicted polypeptide N-acetylgalactosaminyltransferase O Posttranslational modification, protein turnover, chaperones ; IPR000772 [Ricin B, lectin domain] ; IPR001173[Glycosyltransferase 2-like] -- -- G5E8J3 WD repeat-containing protein 11 Wdr11 730 702 747.3 725.8 738.6 704.1 1.00498040119899 0.838928113400449 0.00716736670894497 Nonsignificant None -- -- -- -- -- WD40 repeat protein R General function prediction only ; -- -- -- Q9Z0H8 CAP-Gly domain-containing linker protein 2 Clip2 637.4 681.5 879.2 799.9 797.8 748.9 0.936716952186142 0.551324957125528 -0.0943149203935075 Nonsignificant None -- -- CAP-Gly domain-containing linker protein 2 -- -- Cytoskeleton-associated protein and related proteins ZR Cytoskeleton ; General function prediction only ; IPR000938 [CAP Gly-rich domain] -- -- A6H644 Protein phosphatase 1 regulatory subunit Ppp1r12b 102.1 97.2 93.7 112.8 121.8 105.4 0.861764705882353 0.0424389683047905 -0.214634081715454 Nonsignificant None 1 Molecular Function:protein kinase binding (GO:0019901) protein phosphatase 1 regulatory subunit 12B -- ko04270 Vascular smooth muscle contraction ko04510 Focal adhesion ko04810 Regulation of actin cytoskeleton ko04921 Oxytocin signaling pathway ko05205 Proteoglycans in cancer Myosin phosphatase, regulatory subunit OT Posttranslational modification, protein turnover, chaperones ; Signal transduction mechanisms ; IPR020683 [Ankyrin repeat-containing domain] ; IPR031775[cGMP-dependent protein kinase, interacting domain] -- -- Q91X97 Neurocalcin-delta Ncald 964.8 951.1 1233.6 1167.6 1187.9 1298.3 0.861979309212327 0.169830152549373 -0.214274855335203 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) neurocalcin delta -- ko04740 Olfactory transduction Ca2+ sensor (EF-Hand superfamily) T Signal transduction mechanisms ; IPR002048 [EF-hand domain] -- -- Q9Z261 Claudin-7 Cldn7 738.4 705.4 561 698.7 669.2 785.7 0.930906389301634 0.486250056984765 -0.103291995288457 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) claudin -- ko04514 Cell adhesion molecules (CAMs) ko04530 Tight junction ko04670 Leukocyte transendothelial migration ko05160 Hepatitis C -- -- -- IPR004031 [PMP-22/EMP/MP20/Claudin superfamily] -- -- F8VQ29 IQ motif-containing GTPase-activating protein 3 Iqgap3 255 238.8 225.6 209.2 216.6 236.9 1.08555907650521 0.186478279864652 0.118438240058949 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Biological Process:regulation of GTPase activity (GO:0043087) Ras GTPase-activating-like protein IQGAP2/3 -- ko04810 Regulation of actin cytoskeleton Ras GTPase-activating protein family - IQGAP T Signal transduction mechanisms ; IPR000048 [IQ motif, EF-hand binding site] ; IPR000593[RasGAP protein, C-terminal] ; IPR001715[Calponin homology domain] ; IPR001936[Ras GTPase-activating protein] -- -- Q9Z1W9 STE20/SPS1-related proline-alanine-rich protein kinase Stk39 1093.9 1045.4 1116.6 1031.5 1087.3 1026.6 1.03513066700579 0.26773803978111 0.0498128940459102 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) serine/threonine-protein kinase OSR1/STK39 2.7.11.1 -- Ste20-like serine/threonine protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR024678[Serine/threonine-protein kinase OSR1/WNK, CCT domain] -- -- Q05A21 Death-associated protein kinase 3 Dapk3 191.5 190.1 231.3 234.9 220.6 210.9 0.919717887154862 0.305756852125352 -0.120736695911164 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) death-associated protein kinase 2.7.11.1 ko04140 Autophagy - animal ko05200 Pathways in cancer ko05219 Bladder cancer Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- E9QMK3 Versican core protein Vcan 1365.9 1236.3 1272.9 1371.2 1435.8 1467.2 0.906625801319545 0.0497158371957041 -0.141420875968684 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Molecular Function:hyaluronic acid binding (GO:0005540),Biological Process:cell adhesion (GO:0007155) versican core protein -- ko04514 Cell adhesion molecules (CAMs) -- -- -- IPR000436 [Sushi/SCR/CCP domain] ; IPR000538[Link domain] ; IPR000742[EGF-like domain] ; IPR001304[C-type lectin-like] ; IPR013106[Immunoglobulin V-set domain] -- -- Q9R008 Mevalonate kinase Mvk 837 767.9 654.2 735.1 827.3 788.3 0.96103288382184 0.635509236602452 -0.0573422981078668 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) mevalonate kinase 2.7.1.36 ko00900 Terpenoid backbone biosynthesis ko01100 Metabolic pathways ko04146 Peroxisome Mevalonate kinase MVK/ERG12 I Lipid transport and metabolism ; IPR006204 [GHMP kinase N-terminal domain] ; IPR013750[GHMP kinase, C-terminal domain] -- -- Q9CZJ2 Heat shock 70 kDa protein 12B Hspa12b 269.6 252.7 250.9 268.5 245.3 271.1 0.98509364250223 0.719984374490249 -0.0216672219404538 Nonsignificant None -- -- -- -- -- Molecular chaperones HSP70/HSC70, HSP70 superfamily O Posttranslational modification, protein turnover, chaperones ; -- -- -- Q91YJ5 Translation initiation factor IF-2, mitochondrial Mtif2 502.6 530 546.2 623.8 637.6 618.2 0.839965950202171 0.00199509105976186 -0.251597248508012 Nonsignificant None -- -- translation initiation factor IF-2 -- -- Mitochondrial translation initiation factor 2 (IF-2; GTPase) J Translation, ribosomal structure and biogenesis ; IPR023115 [Translation initiation factor IF- 2, domain 3] -- -- P50295 Arylamine N-acetyltransferase 2 Nat2 691.5 646 754.7 812.5 817.5 799 0.861342116097159 0.0247041832156297 -0.215341720025367 Nonsignificant None 2 Biological Process:metabolic process (GO:0008152),Molecular Function:acetyltransferase activity (GO:0016407) arylamine N-acetyltransferase 2.3.1.5 ko00232 Caffeine metabolism ko00983 Drug metabolism - other enzymes ko01100 Metabolic pathways ko05204 Chemical carcinogenesis -- -- -- IPR001447 [Arylamine N-acetyltransferase] -- -- Q6P5H2 Nestin Nes 621.2 634 651.4 562.6 566.7 497.8 1.17177800995636 0.0177374932009989 0.228699281134124 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) nestin -- -- -- -- -- IPR001664 [Intermediate filament protein] -- -- O54941 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 Smarce1 1061.5 1031.8 1020.4 995.9 1008 983.6 1.04224267782427 0.0408635720652894 0.0596912366665954 Nonsignificant None -- -- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E, member 1 -- ko05225 Hepatocellular carcinoma SWI/SNF-related matrix-associated actin-dependent regulator of chromatin B Chromatin structure and dynamics ; IPR009071 [High mobility group box domain] -- HMG A0A0R4J065 Cysteine protease Atg4b 965 889.2 936.6 973.3 1131.6 1074.4 0.877803290032397 0.0650175007665302 -0.188030417416477 Nonsignificant None -- -- cysteine protease ATG4 3.4.22.- ko04136 Autophagy - other ko04140 Autophagy - animal Cysteine protease required for autophagy - Apg4p/Aut2p ZU Cytoskeleton ; Intracellular trafficking, secretion, and vesicular transport ; IPR005078 [Peptidase C54] -- -- P97434 Myosin phosphatase Rho-interacting protein Mprip 1115.1 1081.7 1040.5 945.2 972.3 1055.3 1.08897335844995 0.0895595663491595 0.122968659195039 Nonsignificant None -- -- -- -- -- F-actin binding protein, regulates actin cytoskeletal organization Z Cytoskeleton ; IPR001849 [Pleckstrin homology domain] -- -- P51655 Glypican-4 Gpc4 885.2 874.3 810.2 873.1 887.8 852.2 0.983391374229842 0.601841279344197 -0.0241623942035223 Nonsignificant None 3 Cellular Component:proteinaceous extracellular matrix (GO:0005578),Cellular Component:membrane (GO:0016020),Molecular Function:heparan sulfate proteoglycan binding (GO:0043395) glypican 4 -- ko04310 Wnt signaling pathway Heparin sulfate cell surface proteoglycan T Signal transduction mechanisms ; IPR001863 [Glypican] -- -- Q9D6U8 Protein FAM162A Fam162a 1742 1845.6 2068.9 1768.9 1644.6 1655.7 1.1158565454115 0.133776352323441 0.158151566122012 Nonsignificant None -- -- -- -- -- -- -- -- IPR009432 [Protein of unknown function DUF1075] -- -- A0A0X1KG60 E3 ubiquitin protein ligase Rnf40 627.2 634.3 703.6 686.9 701.8 661.8 0.958351621555718 0.351532423853763 -0.061373013454411 Nonsignificant None -- -- E3 ubiquitin-protein ligase BRE1 2.3.2.27 -- E3 ubiquitin ligase involved in syntaxin degradation O Posttranslational modification, protein turnover, chaperones ; -- -- -- O35638 Cohesin subunit SA-2 Stag2 754.1 781 741.3 833.6 805 803 0.932339449541284 0.0228471976245101 -0.101072782701899 Nonsignificant None -- -- cohesin complex subunit SA-1/2 -- ko04110 Cell cycle Sister chromatid cohesion complex Cohesin, subunit STAG/IRR1/SCC3 D Cell cycle control, cell division, chromosome partitioning ; IPR013721 [STAG] -- -- Q9D0L8 mRNA cap guanine-N7 methyltransferase Rnmt 729.6 776.5 909.2 844.4 850.1 860.1 0.945470915211775 0.479189388890542 -0.0808950165379522 Nonsignificant None -- -- mRNA (guanine-N7-)-methyltransferase 2.1.1.56 ko03015 mRNA surveillance pathway mRNA cap methyltransferase A RNA processing and modification ; IPR004971 [mRNA (guanine-N(7))-methyltransferase domain] -- -- Q9R1R8 Retinol dehydrogenase 11 Rdh11 1272.7 1308.6 1552.9 1439.8 1428.2 1350 0.980132764343291 0.777566086607154 -0.0289509114894955 Nonsignificant None -- -- retinol dehydrogenase 11 1.1.1.300 ko00830 Retinol metabolism ko01100 Metabolic pathways Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Q Secondary metabolites biosynthesis, transport and catabolism ; IPR002347 [Short-chain dehydrogenase/reductase SDR] -- -- Q91VC7 Protein phosphatase 1 regulatory subunit 14A Ppp1r14a 1142.3 1257.2 1249.3 1600.1 1483.4 1623.5 0.775185893350329 0.00346862745333007 -0.367385777718861 Nonsignificant None 2 Cellular Component:cytoplasm (GO:0005737),Biological Process:regulation of phosphorylation (GO:0042325) protein phosphatase 1 regulatory subunit 14A -- ko04270 Vascular smooth muscle contraction -- -- -- IPR008025 [PKC-activated phosphatase-1 inhibitor] -- -- Q8VHN8 Tudor-interacting repair regulator protein Nudt16l1 621.7 598.9 630.3 567.4 559.4 576.3 1.08678292525395 0.0095620338239845 0.120063804271197 Nonsignificant None -- -- NUDT16-like protein 1 -- ko05205 Proteoglycans in cancer -- -- -- -- -- -- Q497I3 Fatty acid binding protein 5, epidermal Fabp5 2744.3 2837.4 3333 2690.8 2871.7 2547.5 1.09922318125771 0.261572971784367 0.136484334243989 Nonsignificant None -- -- fatty acid-binding protein 5, epidermal -- ko03320 PPAR signaling pathway Fatty acid-binding protein FABP I Lipid transport and metabolism ; IPR000566 [Lipocalin/cytosolic fatty-acid binding domain] -- -- Q99PP9 Tripartite motif-containing protein 16 Trim16 552 498.9 427.5 504.9 530.1 506.5 0.959065844956211 0.599900356544594 -0.0602982275784801 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Cellular Component:intracellular (GO:0005622),Molecular Function:zinc ion binding (GO:0008270) tripartite motif-containing protein 16 -- -- -- -- -- IPR000315 [B-box-type zinc finger] ; IPR003877[SPRY domain] ; IPR006574[SPRY-associated] -- -- O35326 Serine/arginine-rich splicing factor 5 Srsf5 878.6 870.9 896.5 857.9 888.4 871 1.01096549879647 0.457385790488958 0.0157337632502664 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) splicing factor, arginine/serine-rich 4/5/6 -- ko03040 Spliceosome ko05168 Herpes simplex infection Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- Q3TU79 J domain-containing protein Dnajb1 1076.2 1021 1107.8 979.2 1048.3 985.3 1.06379447689857 0.129506202651113 0.0892194517792375 Nonsignificant None -- -- DnaJ homolog subfamily B member 1 -- ko04141 Protein processing in endoplasmic reticulum ko05164 Influenza A Molecular chaperone (DnaJ superfamily) O Posttranslational modification, protein turnover, chaperones ; IPR001623 [DnaJ domain] ; IPR002939[Chaperone DnaJ, C-terminal] -- -- Q8BGF7 PAN2-PAN3 deadenylation complex catalytic subunit Pan2 Pan2 304 287.2 269.3 271.7 252.3 296.5 1.04875076173065 0.457946459768422 0.0686718585264907 Nonsignificant None -- -- PAB-dependent poly(A)-specific ribonuclease subunit 2 3.1.13.4 ko03018 RNA degradation PAB-dependent poly(A) ribonuclease, subunit PAN2 L Replication, recombination and repair ; IPR013520 [Exonuclease, RNase T/DNA polymerase III] ; IPR028881[PAN2 domain] -- -- Q8VHF2 Cadherin-related family member 5 Cdhr5 799.1 733.7 858.9 827.5 905.5 788.4 0.94856032362973 0.435305280596623 -0.0761885702394237 Nonsignificant None -- -- cadherin-related family member 5 -- -- FOG: Cadherin repeats S Function unknown ; -- -- -- Q6S9I0 Kininogen 2 Kng2 294.5 324.2 283 264.6 291.1 275.5 1.08481713185756 0.180022914331786 0.117451867372636 Nonsignificant None 1 Molecular Function:cysteine-type endopeptidase inhibitor activity (GO:0004869) kininogen -- ko04610 Complement and coagulation cascades -- -- -- IPR000010 [Cystatin domain] -- -- Q3UH60 Disco-interacting protein 2 homolog B Dip2b 567.8 571.3 563 639.3 630.2 631.3 0.895465067340067 0.0000599237314008848 -0.159290942026489 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) -- -- -- Predicted AMP-binding protein R General function prediction only ; IPR000873 [AMP-dependent synthetase/ligase] ; IPR010506[DMAP1-binding domain] -- -- Q9CXU9 Eukaryotic translation initiation factor 1b Eif1b 63.1 67 29.9 54.5 55 48.6 1.01201771030993 0.960269927488852 0.0172345374163538 Nonsignificant None 2 Molecular Function:translation initiation factor activity (GO:0003743),Biological Process:translational initiation (GO:0006413) translation initiation factor 1 -- ko03013 RNA transport Translation initiation factor 1 (eIF-1/SUI1) J Translation, ribosomal structure and biogenesis ; IPR001950 [SUI1 domain] -- -- Q8BG81 Polymerase delta-interacting protein 3 Poldip3 1016.1 1025.8 916.6 1028.6 1035.2 955.4 0.979895336512984 0.664347929729294 -0.0293004329630691 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) RRM motif-containing protein A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- Q9EQQ9 Protein O-GlcNAcase Oga 877.2 833.4 866 846.3 912.5 868.6 0.980665296490827 0.510497653299645 -0.0281672698462268 Nonsignificant None -- -- -- -- ko04931 Insulin resistance Hyaluronoglucosaminidase O Posttranslational modification, protein turnover, chaperones ; IPR011496 [Beta-N-acetylglucosaminidase] -- -- Q4FJR4 Protein-serine/threonine kinase Pdk3 1701.8 1718.4 1818.3 1656.9 1735.5 1751.4 1.01841051362806 0.535809237893957 0.0263192181861246 Nonsignificant None -- -- pyruvate dehydrogenase kinase 2/3/4 2.7.11.2 -- Dehydrogenase kinase T Signal transduction mechanisms ; IPR003594 [Histidine kinase-like ATPase, C-terminal domain] ; IPR018955[Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal] -- -- P61022 Calcineurin B homologous protein 1 Chp1 1314.7 1274.9 1729 1441.8 1417.4 1493.4 0.992188576942517 0.945245959377561 -0.0113137472952 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) calcineurin B homologous protein 1 -- -- Ca2+/calmodulin-dependent protein phosphatase (calcineurin subunit B), EF-Hand superfamily protein T Signal transduction mechanisms ; IPR002048 [EF-hand domain] -- -- B9EIV8 Solute carrier family 12, member 7 Slc12a7 1324.4 1289.7 1266.6 1456.9 1567.5 1431.4 0.870932268055119 0.0130744846531151 -0.199367569335981 Nonsignificant None 5 Molecular Function:transporter activity (GO:0005215),Biological Process:transport (GO:0006810),Biological Process:ion transport (GO:0006811),Cellular Component:membrane (GO:0016020),Biological Process:transmembrane transport (GO:0055085) solute carrier family 12 (potassium/chloride transporter), member 7 -- ko04966 Collecting duct acid secretion K+/Cl- cotransporter KCC1 and related transporters P Inorganic ion transport and metabolism ; IPR004841 [Amino acid permease/ SLC12A domain] ; IPR018491[SLC12A transporter, C-terminal] -- -- Q8R086 Sulfite oxidase, mitochondrial Suox 810.1 743.9 594 587.8 603.7 608.2 1.1935322553759 0.21004822244964 0.255237555981515 Nonsignificant None 4 Molecular Function:oxidoreductase activity (GO:0016491),Molecular Function:molybdenum ion binding (GO:0030151),Biological Process:nitrate assimilation (GO:0042128),Biological Process:oxidation-reduction process (GO:0055114) sulfite oxidase 1.8.3.1 ko00920 Sulfur metabolism ko01100 Metabolic pathways Sulfite oxidase, molybdopterin-binding component C Energy production and conversion ; IPR000572 [Oxidoreductase, molybdopterin-binding domain] ; IPR001199[Cytochrome b5-like heme/steroid binding domain] ; IPR005066[Moybdenum cofactor oxidoreductase, dimerisation] -- -- A0A0N4SWI4 Protein FAM136A Fam136a 1048.5 1014.3 992.1 1004.6 1095 1065 0.965335271440308 0.30673665958604 -0.0508980017932893 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR008560 [Protein of unknown function DUF842, eukaryotic] -- -- Q9JJI8 60S ribosomal protein L38 Rpl38 3133.2 3192.5 2045.5 1959.2 1932.6 1877.6 1.45096543834714 0.144969316839764 0.537013155159979 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L38e -- ko03010 Ribosome 60S ribosomal protein L38 J Translation, ribosomal structure and biogenesis ; IPR002675 [Ribosomal protein L38e] -- -- Q9CQ92 Mitochondrial fission 1 protein Fis1 951.4 939.3 854.8 992 949.1 1053.5 0.916816937153543 0.125074955788741 -0.125294398391022 Nonsignificant None -- -- mitochondrial fission 1 protein -- ko04137 Mitophagy - animal Membrane protein involved in organellar division M Cell wall/membrane/envelope biogenesis ; IPR028058 [Fis1, N-terminal tetratricopeptide repeat] ; IPR028061[Fis1, C-terminal tetratricopeptide repeat] -- -- Q3TZU9 Uncharacterized protein Nectin2 745.3 671.9 625.1 609.2 612 660.5 1.08534835521071 0.23919907871147 0.118158166792731 Nonsignificant None -- -- poliovirus receptor-related protein 2 -- ko04514 Cell adhesion molecules (CAMs) ko04520 Adherens junction ko05168 Herpes simplex infection -- -- -- IPR013106 [Immunoglobulin V-set domain] ; IPR013162[CD80-like, immunoglobulin C2-set] -- -- O08912 Polypeptide N-acetylgalactosaminyltransferase 1 Galnt1 1508.8 1447.1 1594.7 1491.7 1511.6 1486.2 1.01360953335561 0.663936047414288 0.0195019987115045 Nonsignificant None -- -- polypeptide N-acetylgalactosaminyltransferase 2.4.1.41 ko00512 Mucin type O-glycan biosynthesis ko01100 Metabolic pathways Polypeptide N-acetylgalactosaminyltransferase O Posttranslational modification, protein turnover, chaperones ; IPR000772 [Ricin B, lectin domain] ; IPR001173[Glycosyltransferase 2-like] -- -- Q5BL05 Homeobox protein cut-like Cux1 18.7 21.7 16.8 20.1 21 20.5 0.928571428571428 0.368966152726321 -0.106915203916512 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) homeobox protein cut-like -- -- Transcription factor/CCAAT displacement protein CDP1 K Transcription ; IPR001356 [Homeobox domain] ; IPR003350[CUT domain] -- CUT Q3U9K9 Trafficking protein particle complex subunit Trappc3 1124 1051.8 921.2 913.2 924.1 1025.9 1.08165688739871 0.324018099373877 0.113242934145641 Nonsignificant None -- -- trafficking protein particle complex subunit 3 -- -- Transport protein particle (TRAPP) complex subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR007194 [Transport protein particle (TRAPP) component] -- -- Q3TB93 Uncharacterized protein (Fragment) Ptpn1 998.9 1210.3 1288.3 1046.1 1079.4 1049.9 1.10143603955407 0.33980844882904 0.139385720097969 Nonsignificant None 2 Molecular Function:protein tyrosine phosphatase activity (GO:0004725),Biological Process:protein dephosphorylation (GO:0006470) tyrosine-protein phosphatase non-receptor type 1 3.1.3.48 ko04520 Adherens junction ko04910 Insulin signaling pathway ko04931 Insulin resistance Protein tyrosine phosphatase T Signal transduction mechanisms ; IPR000242 [PTP type protein phosphatase] -- -- Q8VCF0 Mitochondrial antiviral-signaling protein Mavs 557.6 556.9 578.4 622.2 654.9 590.4 0.906506024096385 0.0431145858815805 -0.141611487598454 Nonsignificant None -- -- mitochondrial antiviral-signaling protein -- ko04621 NOD-like receptor signaling pathway ko04622 RIG-I-like receptor signaling pathway ko04623 Cytosolic DNA-sensing pathway ko05160 Hepatitis C ko05161 Hepatitis B ko05162 Measles ko05164 Influenza A ko05168 Herpes simplex infection -- -- -- IPR031964 [Caspase recruitment domain] -- -- Q91V35 Receptor-type tyrosine-protein phosphatase alpha Ptpra 655.1 626.5 673.1 640.5 694.6 733.6 0.944892927925751 0.276882312984804 -0.0817772376196301 Nonsignificant None 2 Molecular Function:protein tyrosine phosphatase activity (GO:0004725),Biological Process:protein dephosphorylation (GO:0006470) receptor-type tyrosine-protein phosphatase A 3.1.3.48 -- Protein tyrosine phosphatase T Signal transduction mechanisms ; IPR000242 [PTP type protein phosphatase] -- -- Q9CQA9 Cancer-related nucleoside-triphosphatase homolog Ntpcr 548.6 532.1 531.4 526.5 556.2 573.7 0.973255252354504 0.377145718998349 -0.0391098695194288 Nonsignificant None -- -- nucleoside-triphosphatase 3.6.1.15 ko00230 Purine metabolism ko00730 Thiamine metabolism ko01100 Metabolic pathways -- -- -- IPR004948 [Nucleoside-triphosphatase, THEP1 type] -- -- Q9CQB4 Cytochrome b-c1 complex subunit 7 Uqcrb 3961.8 3727.1 4008.4 4670.3 4448.3 4557.4 0.855315881836794 0.00365010090448013 -0.225470766120954 Nonsignificant None 1 Cellular Component:mitochondrial respiratory chain complex III (GO:0005750) ubiquinol-cytochrome c reductase subunit 7 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04260 Cardiac muscle contraction ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Ubiquinol cytochrome c reductase, subunit QCR7 C Energy production and conversion ; IPR003197 [Cytochrome b-c1 complex subunit 7] -- -- Q8CI11 Guanine nucleotide-binding protein-like 3 Gnl3 522.6 507.5 481.6 403.2 438.5 447.9 1.17222394540943 0.0150376615009141 0.229248213162942 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) nuclear GTP-binding protein -- ko03008 Ribosome biogenesis in eukaryotes GTPase R General function prediction only ; IPR006073 [GTP binding domain] ; IPR014813[Guanine nucleotide-binding protein-like 3, N-terminal domain] -- -- P06837 Neuromodulin Gap43 768 755.4 1167.2 1214.6 1155 1271 0.739054002087568 0.0854206506115331 -0.436248310086295 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Biological Process:regulation of growth (GO:0040008) neuromodulin -- -- -- -- -- IPR000048 [IQ motif, EF-hand binding site] ; IPR017454[Neuromodulin (GAP-43), C-terminal] ; IPR018947[Neuromodulin gap junction N-terminal] -- -- Q8R3D1 TBC1 domain family member 13 Tbc1d13 1082.6 1024 1001.2 1009.5 1004.3 1024.3 1.02294197031039 0.404861628478493 0.032724305865258 Nonsignificant None -- -- -- -- -- GTPase-activating protein R General function prediction only ; IPR000195 [Rab-GTPase-TBC domain] -- -- Q8BJU0 Small glutamine-rich tetratricopeptide repeat-containing protein alpha Sgta 602.5 618.5 569 559.3 534.9 531.1 1.10133513812835 0.0322907577348017 0.13925355023113 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) small glutamine-rich tetratricopeptide repeat-containing protein alpha -- -- TPR repeat-containing protein R General function prediction only ; IPR001440 [Tetratricopeptide repeat 1] ; IPR019734[Tetratricopeptide repeat] ; IPR032374[SGTA, homodimerisation domain] -- -- Q91WM2 Haloacid dehalogenase-like hydrolase domain-containing 5 Hdhd5 554.6 479.6 530.3 604.9 561.4 621.2 0.875244755244755 0.0589723036417754 -0.192241583312192 Nonsignificant None -- -- -- -- -- Predicted phosphatase R General function prediction only ; IPR006357 [HAD-superfamily hydrolase, subfamily IIA] -- -- Q8R0K2 E3 ubiquitin-protein ligase TRIM31 Trim31 941.7 977.5 946.8 1085.8 1172.3 1048.8 0.866672714626992 0.0184451006882341 -0.206440809776744 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Cellular Component:intracellular (GO:0005622),Molecular Function:zinc ion binding (GO:0008270) tripartite motif-containing protein 31 2.3.2.27 -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR000315 [B-box-type zinc finger] ; IPR003877[SPRY domain] -- -- Q9DB16 Calcium-binding protein 39-like Cab39l 155.4 158.4 139.8 160.6 157.3 164.4 0.940493468795356 0.193017324031758 -0.0885101698196665 Nonsignificant None -- -- calcium binding protein 39 -- ko04150 mTOR signaling pathway ko04152 AMPK signaling pathway Conserved protein Mo25 S Function unknown ; IPR013878 [Mo25-like] -- -- Q8C2D2 Uncharacterized protein Ufd1 987.5 951.2 923.4 869.7 899.8 912 1.06735036360246 0.054899920769305 0.0940338264541915 Nonsignificant None 1 Biological Process:ubiquitin-dependent protein catabolic process (GO:0006511) ubiquitin fusion degradation protein 1 -- ko04141 Protein processing in endoplasmic reticulum Ubiquitin fusion-degradation protein O Posttranslational modification, protein turnover, chaperones ; IPR004854 [Ubiquitin fusion degradation protein UFD1] -- -- P97290 Plasma protease C1 inhibitor Serping1 1474.2 1398.2 1216.3 929.7 1015 1018.2 1.37996557426845 0.0101326721977163 0.464632276821069 Nonsignificant None -- -- C1 inhibitor -- ko04610 Complement and coagulation cascades ko05133 Pertussis Serpin V Defense mechanisms ; IPR023796 [Serpin domain] -- -- A0A5F8MQ17 Aquaporin-4 Aqp4 27.7 27.1 59.6 59.6 75.1 50.9 0.616379310344828 0.138657009497757 -0.698109658349183 Nonsignificant None 3 Molecular Function:transporter activity (GO:0005215),Biological Process:transport (GO:0006810),Cellular Component:membrane (GO:0016020) aquaporin-4 -- ko04962 Vasopressin-regulated water reabsorption ko04976 Bile secretion Aquaporin (major intrinsic protein family) G Carbohydrate transport and metabolism ; IPR000425 [Major intrinsic protein] -- -- Q9CZC8 Secernin-1 Scrn1 375.7 327.4 305.8 363.5 391.9 414 0.862750128270908 0.102053122457605 -0.212985311731307 Nonsignificant None 2 Biological Process:proteolysis (GO:0006508),Molecular Function:dipeptidase activity (GO:0016805) secernin -- -- -- -- -- IPR005322 [Peptidase C69, dipeptidase A] -- -- P29788 Vitronectin Vtn 930 1050.4 811.1 508 557.9 527.5 1.75191414585164 0.00481044581904789 0.808932076086917 Significant up 3 Molecular Function:scavenger receptor activity (GO:0005044),Biological Process:immune response (GO:0006955),Molecular Function:polysaccharide binding (GO:0030247) vitronectin -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04610 Complement and coagulation cascades ko05165 Human papillomavirus infection ko05205 Proteoglycans in cancer Gelatinase A and related matrix metalloproteases OW Posttranslational modification, protein turnover, chaperones ; Extracellular structures ; IPR001212 [Somatomedin B domain] ; IPR018487[Hemopexin-like repeats] -- -- Q04207 Transcription factor p65 Rela 847.1 896 946.3 830.4 838.7 801.7 1.08847336894933 0.0768702089183086 0.122306110369721 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) transcription factor p65 -- ko01523 Antifolate resistance ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04024 cAMP signaling pathway ko04062 Chemokine signaling pathway ko04064 NF-kappa B signaling pathway ko04066 HIF-1 signaling pathway ko04071 Sphingolipid signaling pathway ko04137 Mitophagy - animal ko04151 PI3K-Akt signaling pathway ko04210 Apoptosis ko04211 Longevity regulating pathway ko04218 Cellular senescence ko04380 Osteoclast differentiation ko04620 Toll-like receptor signaling pathway ko04621 NOD-like receptor signaling pathway ko04622 RIG-I-like receptor signaling pathway ko04623 Cytosolic DNA-sensing pathway ko04657 IL-17 signaling pathway ko04658 Th1 and Th2 cell differentiation ko04659 Th17 cell differentiation ko04660 T cell receptor signaling pathway ko04662 B cell receptor signaling pathway ko04668 TNF signaling pathway ko04722 Neurotrophin signaling pathway ko04917 Prolactin signaling pathway ko04920 Adipocytokine signaling pathway ko04926 Relaxin signaling pathway ko04931 Insulin resistance ko04932 Non-alcoholic fatty liver disease (NAFLD) ko04933 AGE-RAGE signaling pathway in diabetic complications ko05030 Cocaine addiction ko05132 Salmonella infection ko05133 Pertussis ko05134 Legionellosis ko05140 Leishmaniasis ko05142 Chagas disease (American trypanosomiasis) ko05145 Toxoplasmosis ko05146 Amoebiasis ko05152 Tuberculosis ko05160 Hepatitis C ko05161 Hepatitis B ko05162 Measles ko05164 Influenza A ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05202 Transcriptional misregulation in cancer ko05203 Viral carcinogenesis ko05212 Pancreatic cancer ko05215 Prostate cancer ko05220 Chronic myeloid leukemia ko05221 Acute myeloid leukemia ko05222 Small cell lung cancer ko05321 Inflammatory bowel disease (IBD) ko05418 Fluid shear stress and atherosclerosis -- -- -- IPR011539 [Rel homology domain (RHD), DNA-binding domain] ; IPR032397[Rel homology dimerisation domain] -- RHD Q3TIU4 2,5-phosphodiesterase 12 Pde12 550.8 498.3 775.9 771.2 626 609.7 0.909362698689521 0.574894319655197 -0.137072267756024 Nonsignificant None -- -- -- -- -- Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins K Transcription ; IPR005135 [Endonuclease/exonuclease/phosphatase] -- -- Q6PGF7 Exocyst complex component 8 Exoc8 1657.8 1614.7 1607.9 1501 1516.4 1520.5 1.07547544018158 0.00240224562247882 0.104974579402717 Nonsignificant None -- -- exocyst complex component 8 -- -- Exocyst complex subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR032403 [Exocyst component Exo84, C-terminal] -- -- Q9ERB0 Synaptosomal-associated protein 29 Snap29 1575.7 1579 1457.6 1506.1 1535.7 1467.7 1.02279631888236 0.484386015088945 0.03251887333815 Nonsignificant None -- -- synaptosomal-associated protein 29 -- ko04130 SNARE interactions in vesicular transport ko04140 Autophagy - animal SNAP-25 (synaptosome-associated protein) component of SNARE complex U Intracellular trafficking, secretion, and vesicular transport ; -- -- -- Q5SUV8 Uncharacterized protein Ddc 451.1 434.3 452.2 558.1 509.5 578.9 0.812389918007896 0.00852392710743439 -0.299755759401827 Nonsignificant None 3 Molecular Function:carboxy-lyase activity (GO:0016831),Biological Process:carboxylic acid metabolic process (GO:0019752),Molecular Function:pyridoxal phosphate binding (GO:0030170) aromatic-L-amino-acid decarboxylase 4.1.1.28 ko00350 Tyrosine metabolism ko00360 Phenylalanine metabolism ko00380 Tryptophan metabolism ko01100 Metabolic pathways ko04726 Serotonergic synapse ko04728 Dopaminergic synapse ko05030 Cocaine addiction ko05031 Amphetamine addiction ko05034 Alcoholism Aromatic-L-amino-acid/L-histidine decarboxylase E Amino acid transport and metabolism ; IPR002129 [Pyridoxal phosphate-dependent decarboxylase] -- -- Q64444 Carbonic anhydrase 4 Ca4 1756.9 1485.5 1671.1 2339.8 2288.3 2121.8 0.727936710173484 0.00411358021964737 -0.458115072881086 Nonsignificant None -- -- carbonic anhydrase 4 4.2.1.1 ko00910 Nitrogen metabolism ko04964 Proximal tubule bicarbonate reclamation Carbonic anhydrase R General function prediction only ; IPR001148 [Alpha carbonic anhydrase] -- -- Q3U8A5 Exocyst complex component 5 Exoc5 571.4 647.8 622.6 717.6 718.5 696.1 0.863802645155239 0.0149143620172294 -0.211226360483545 Nonsignificant None 3 Cellular Component:cytoplasm (GO:0005737),Biological Process:exocytosis (GO:0006887),Biological Process:vesicle docking (GO:0048278) exocyst complex component 5 -- -- Exocyst subunit - Sec10p U Intracellular trafficking, secretion, and vesicular transport ; IPR009976 [Exocyst complex component Sec10-like] -- -- Q61107 Guanylate-binding protein 4 Gbp4 626.5 583.6 607.8 561.7 682.5 589.9 0.991167330025626 0.895346651745541 -0.0127994594536239 Nonsignificant None 2 Molecular Function:GTPase activity (GO:0003924),Molecular Function:GTP binding (GO:0005525) guanylate-binding protein 1/3/4/7 -- ko04621 NOD-like receptor signaling pathway Guanylate-binding protein R General function prediction only ; IPR003191 [Guanylate-binding protein, C-terminal] ; IPR015894[Guanylate-binding protein, N-terminal] -- -- Q8BG73 SH3 domain-binding glutamic acid-rich-like protein 2 Sh3bgrl2 867.7 723 620.9 669.2 646 721.5 1.0858742082781 0.48036480215312 0.118856985642665 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR006993 [SH3-binding, glutamic acid-rich protein] -- -- A0A0G2JFJ6 Integrator complex subunit 3 Ints3 433.5 500.6 432.2 422.7 425.8 411.5 1.08436507936508 0.198270416022642 0.116850558828629 Nonsignificant None -- -- integrator complex subunit 3 -- -- Uncharacterized conserved protein S Function unknown ; IPR019333 [Integrator complex subunit 3] -- -- A0A338P6W9 ABI family member 3-binding protein Abi3bp 1417.8 1337.2 1469.9 1823.8 1881.1 1817.7 0.765020099228624 0.000577595364407141 -0.386430442929731 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR003961 [Fibronectin type III] -- -- Q8R151 NFX1-type zinc finger-containing protein 1 Znfx1 776.1 747.8 755.8 757.3 778.5 781.9 0.983604435431678 0.329155500589437 -0.02384985429979 Nonsignificant None -- -- -- -- -- Helicases L Replication, recombination and repair ; -- -- -- Q7TQH0 Ataxin-2-like protein Atxn2l 1933.9 1812.8 1356.2 1227.3 1274 1191.4 1.38188859100387 0.113569838655607 0.466641309152286 Nonsignificant None -- -- -- -- -- Protein interacting with poly(A)-binding protein A RNA processing and modification ; IPR009604 [LsmAD domain] ; IPR009818[Ataxin-2, C-terminal] ; IPR025852[Ataxin 2, SM domain] -- -- Q9JMC8 Band 4.1-like protein 4B Epb41l4b 479 468.3 516.8 521.8 526.4 485.8 0.954432855280313 0.298645710724727 -0.0672843878411068 Nonsignificant None -- -- band 4.1-like protein 4B -- ko04530 Tight junction FERM domain protein EHM2 R General function prediction only ; IPR014847 [FERM adjacent (FA)] ; IPR018979[FERM, N-terminal] ; IPR018980[FERM, C-terminal PH-like domain] ; IPR019748[FERM central domain] -- -- Q8CHS9 Nup214 protein Nup214 639.5 632.3 866 752 706.4 717.8 0.982354562999724 0.877518419530515 -0.0256842618369802 Nonsignificant None -- -- nuclear pore complex protein Nup214 -- ko03013 RNA transport ko05169 Epstein-Barr virus infection Nuclear pore complex, Nup214/CAN component YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; -- -- -- Q9EQ80 NIF3-like protein 1 Nif3l1 1147 1158.7 1132.3 1112.9 1162.5 1217.1 0.984395132426628 0.589858887143204 -0.0226905708187644 Nonsignificant None -- -- -- -- -- Ngg1-interacting factor 3 protein NIF3L1 R General function prediction only ; IPR002678 [GTP cyclohydrolase 1 type 2/Nif3] -- -- Q80ZV0 Ribonuclease H2 subunit B Rnaseh2b 1061.9 1090.2 1251.8 1089.7 1110.3 1126 1.02342152736019 0.687859152144415 0.0334004854306422 Nonsignificant None 1 Cellular Component:nucleus (GO:0005634) ribonuclease H2 subunit B -- ko03030 DNA replication Uncharacterized conserved protein S Function unknown ; IPR019024 [Ribonuclease H2, subunit B] -- -- A0A494B9H1 Nucleotide exchange factor SIL1 Sil1 817.7 804.6 827 744.9 828.4 762 1.04881599794459 0.221747984671266 0.0687615967547788 Nonsignificant None -- -- nucleotide exchange factor SIL1 -- ko04141 Protein processing in endoplasmic reticulum Armadillo/beta-catenin-like repeat-containing protein O Posttranslational modification, protein turnover, chaperones ; IPR013918 [Nucleotide exchange factor Fes1] -- -- Q9DB60 Prostamide/prostaglandin F synthase Prxl2b 1026.4 927 932.2 989.3 1086.9 1057.9 0.920710889888644 0.128742935542679 -0.11917988450232 Nonsignificant None -- -- prostamide/prostaglandin F2alpha synthase 1.11.1.20 ko00590 Arachidonic acid metabolism ko01100 Metabolic pathways Uncharacterized conserved protein S Function unknown ; IPR032801 [Peroxiredoxin-like FAM213/AAED1] -- -- B2ZRS3 Depdc6-001 Deptor 798.1 724.8 690.5 843.8 864.6 870.9 0.858139805373551 0.0204477788366248 -0.220715388784516 Nonsignificant None 1 Biological Process:intracellular signal transduction (GO:0035556) DEP domain-containing mTOR-interacting protein -- ko04140 Autophagy - animal ko04150 mTOR signaling pathway -- -- -- IPR000591 [DEP domain] -- -- Q9CRB2 H/ACA ribonucleoprotein complex subunit 2 Nhp2 685.5 683.8 645.1 718 735.3 741.1 0.917973022238425 0.0157951081159344 -0.123476339129261 Nonsignificant None -- -- H/ACA ribonucleoprotein complex subunit 2 -- ko03008 Ribosome biogenesis in eukaryotes Box H/ACA snoRNP component, involved in ribosomal RNA pseudouridinylation A RNA processing and modification ; IPR004038 [Ribosomal protein L7Ae/L30e/S12e/Gadd45] -- -- Q3UW68 Calpain-13 Capn13 1533.6 1302.7 1282.3 1734.7 2195.7 1948.7 0.700549403820313 0.0196099831235914 -0.513441299572728 Nonsignificant None 3 Molecular Function:calcium-dependent cysteine-type endopeptidase activity (GO:0004198),Cellular Component:intracellular (GO:0005622),Biological Process:proteolysis (GO:0006508) calpain-13 3.4.22.- -- Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) OT Posttranslational modification, protein turnover, chaperones ; Signal transduction mechanisms ; IPR001300 [Peptidase C2, calpain, catalytic domain] ; IPR022682[Peptidase C2, calpain, large subunit, domain III] -- -- Q58E38 Sphingosine kinase 2 Sphk2 464 421.6 367.3 440.6 473.4 454.6 0.915461055092796 0.261922497504161 -0.127429581687885 Nonsignificant None 1 Molecular Function:kinase activity (GO:0016301) sphingosine kinase 2.7.1.91 ko00600 Sphingolipid metabolism ko01100 Metabolic pathways ko04020 Calcium signaling pathway ko04071 Sphingolipid signaling pathway ko04072 Phospholipase D signaling pathway ko04370 VEGF signaling pathway ko04371 Apelin signaling pathway ko04666 Fc gamma R-mediated phagocytosis ko05152 Tuberculosis Sphingosine kinase, involved in sphingolipid metabolism IT Lipid transport and metabolism ; Signal transduction mechanisms ; IPR001206 [Diacylglycerol kinase, catalytic domain] -- -- A0A2I3BRD1 TBC1 domain family member 23 Tbc1d23 841 804.4 846.5 701.1 715 706.3 1.17409536373916 0.000876359357636651 0.231549593461633 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein, contains TBC and Rhodanese domains R General function prediction only ; IPR000195 [Rab-GTPase-TBC domain] ; IPR001763[Rhodanese-like domain] -- -- Q9Z0Y1 Dynactin subunit 3 Dctn3 949.1 856 1007.2 1015.8 1040 1070.9 0.899446700994659 0.088847840372923 -0.15289030144721 Nonsignificant None -- -- dynactin 3 -- -- -- -- -- IPR009991 [Dynactin subunit p22] -- -- Q78JE5 F-box only protein 22 Fbxo22 671.8 638.8 647 686.9 754.8 713.2 0.908441226971089 0.0409919644065418 -0.138534914825494 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) F-box protein 22 -- -- -- -- -- IPR001810 [F-box domain] ; IPR019494[FIST, C-domain] -- -- Q0VE46 Myadm protein Myadm 1529.5 1429.7 1372.1 1582.6 1433 1394 0.982243287373004 0.740804025848232 -0.0258476915129131 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) -- -- -- Members of chemokine-like factor super family and related proteins V Defense mechanisms ; IPR008253 [Marvel domain] -- -- E9PUW7 Exportin-7 Xpo7 390.3 414.9 403.9 348.4 361.4 398.6 1.09085167809455 0.1138565309203 0.125454953334918 Nonsignificant None 2 Biological Process:intracellular protein transport (GO:0006886),Molecular Function:Ran GTPase binding (GO:0008536) exportin-7 -- -- Nuclear transport receptor RanBP16 (importin beta superfamily) YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; IPR001494 [Importin-beta, N-terminal domain] -- -- Q3UDH7 RRM domain-containing protein Srsf10 1877.9 1810 1734.8 1549.7 1549.5 1581.3 1.15857280205106 0.0043952843199808 0.212348702690441 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) FUS-interacting serine-arginine-rich protein 1 -- ko03040 Spliceosome FOG: RRM domain R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- A0A0R4J1G9 Metalloreductase STEAP3 Steap3 606 594.7 709.1 645 642 621.2 1.00083848653181 0.989235584161385 0.00120917349426353 Nonsignificant None -- -- metalloreductase STEAP3 1.16.1.- ko04115 p53 signaling pathway ko04216 Ferroptosis -- -- -- IPR013130 [Ferric reductase transmembrane component-like domain] ; IPR028939[Pyrroline-5-carboxylate reductase, catalytic, N-terminal] -- -- Q8BJZ4 28S ribosomal protein S35, mitochondrial Mrps35 1030.5 1011.4 807.5 696.9 779.1 799.3 1.25231837559882 0.0700237873648711 0.324601383761369 Nonsignificant None -- -- small subunit ribosomal protein S35 -- -- Mitochondrial ribosomal protein S28 J Translation, ribosomal structure and biogenesis ; IPR019349 [Ribosomal protein S24/S35, mitochondrial, conserved domain] -- -- A0A668KLG2 Sorbin and SH3 domain-containing protein 1 (Fragment) Sorbs1 271.2 277.8 240.7 287.6 299.7 299 0.891007559517094 0.0560764082051489 -0.166490422925174 Nonsignificant None -- -- sorbin and SH3 domain containing 1 -- ko03320 PPAR signaling pathway ko04520 Adherens junction ko04910 Insulin signaling pathway Sorbin and SH3 domain-containing protein T Signal transduction mechanisms ; -- -- -- Q6ZWQ7 Signal peptidase complex subunit 3 Spcs3 1253.3 1327.1 1277.6 1281.6 1320.4 1188.1 1.01791509458853 0.640477855687673 0.025617229660615 Nonsignificant None 4 Cellular Component:signal peptidase complex (GO:0005787),Biological Process:signal peptide processing (GO:0006465),Molecular Function:peptidase activity (GO:0008233),Cellular Component:integral component of membrane (GO:0016021) signal peptidase complex subunit 3 3.4.-.- ko03060 Protein export Signal peptidase complex subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR007653 [Signal peptidase complex subunit 3] -- -- Q99LD4 COP9 signalosome complex subunit 1 Gps1 966.8 990.6 1015.8 1073 1058 1061.6 0.931278581720228 0.00790566059398902 -0.102715296225724 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) COP9 signalosome complex subunit 1 -- -- COP9 signalosome, subunit CSN1 OT Posttranslational modification, protein turnover, chaperones ; Signal transduction mechanisms ; IPR000717 [Proteasome component (PCI) domain] ; IPR019585[26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1] -- -- Q8C754 Vacuolar protein sorting-associated protein 52 homolog Vps52 874.8 853.4 901.2 928.1 967.7 955.4 0.922208193041526 0.015072276987832 -0.116835611952666 Nonsignificant None -- -- vacuolar protein sorting-associated protein 52 -- -- Vacuolar sorting protein VPS52/suppressor of actin Sac2 UZ Intracellular trafficking, secretion, and vesicular transport ; Cytoskeleton ; IPR007258 [Vps52] -- -- Q99N95 39S ribosomal protein L3, mitochondrial Mrpl3 1465.5 1267.5 933.1 991.8 988.8 1059.3 1.20599361821113 0.310460432648152 0.270222272910036 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L3 -- ko03010 Ribosome Mitochondrial/chloroplast ribosomal protein L3 J Translation, ribosomal structure and biogenesis ; IPR000597 [Ribosomal protein L3] -- -- Q8BS26 Uncharacterized protein Akt1 570.3 503 522.3 474.6 457.6 552.9 1.07440576392162 0.358297078064068 0.103538949601405 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) RAC serine/threonine-protein kinase 2.7.11.1 ko01521 EGFR tyrosine kinase inhibitor resistance ko01522 Endocrine resistance ko01524 Platinum drug resistance ko04010 MAPK signaling pathway ko04012 ErbB signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04062 Chemokine signaling pathway ko04066 HIF-1 signaling pathway ko04068 FoxO signaling pathway ko04071 Sphingolipid signaling pathway ko04072 Phospholipase D signaling pathway ko04140 Autophagy - animal ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04152 AMPK signaling pathway ko04210 Apoptosis ko04211 Longevity regulating pathway ko04213 Longevity regulating pathway - multiple species ko04218 Cellular senescence ko04261 Adrenergic signaling in cardiomyocytes ko04370 VEGF signaling pathway ko04371 Apelin signaling pathway ko04380 Osteoclast differentiation ko04510 Focal adhesion ko04550 Signaling pathways regulating pluripotency of stem cells ko04611 Platelet activation ko04620 Toll-like receptor signaling pathway ko04630 Jak-STAT signaling pathway ko04660 T cell receptor signaling pathway ko04662 B cell receptor signaling pathway ko04664 Fc epsilon RI signaling pathway ko04666 Fc gamma R-mediated phagocytosis ko04668 TNF signaling pathway ko04722 Neurotrophin signaling pathway ko04725 Cholinergic synapse ko04728 Dopaminergic synapse ko04910 Insulin signaling pathway ko04914 Progesterone-mediated oocyte maturation ko04915 Estrogen signaling pathway ko04917 Prolactin signaling pathway ko04919 Thyroid hormone signaling pathway ko04920 Adipocytokine signaling pathway ko04922 Glucagon signaling pathway ko04923 Regulation of lipolysis in adipocytes ko04926 Relaxin signaling pathway ko04931 Insulin resistance ko04932 Non-alcoholic fatty liver disease (NAFLD) ko04933 AGE-RAGE signaling pathway in diabetic complications ko04973 Carbohydrate digestion and absorption ko05142 Chagas disease (American trypanosomiasis) ko05145 Toxoplasmosis ko05152 Tuberculosis ko05160 Hepatitis C ko05161 Hepatitis B ko05162 Measles ko05164 Influenza A ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05210 Colorectal cancer ko05211 Renal cell carcinoma ko05212 Pancreatic cancer ko05213 Endometrial cancer ko05214 Glioma ko05215 Prostate cancer ko05218 Melanoma ko05220 Chronic myeloid leukemia ko05221 Acute myeloid leukemia ko05222 Small cell lung cancer ko05223 Non-small cell lung cancer ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer ko05230 Central carbon metabolism in cancer ko05231 Choline metabolism in cancer ko05418 Fluid shear stress and atherosclerosis Serine/threonine protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR001849[Pleckstrin homology domain] ; IPR017892[Protein kinase, C-terminal] -- -- Q8BG07 5-3 exonuclease PLD4 Pld4 588.3 687.5 572.3 506.4 497.2 479.9 1.24577013818672 0.0300093849826602 0.317037895737108 Nonsignificant None 1 Molecular Function:catalytic activity (GO:0003824) phospholipase D3/4 3.1.4.4 ko00564 Glycerophospholipid metabolism ko00565 Ether lipid metabolism ko01100 Metabolic pathways Predicted phospholipase D R General function prediction only ; IPR001736 [Phospholipase D/Transphosphatidylase] ; IPR032803[PLD-like domain] -- -- S4R2U7 CUGBP Elav-like family member 2 Celf2 381.9 414 602.5 538.1 533.2 528.4 0.874163905732325 0.43236295708374 -0.194024284478278 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) CUG-BP- and ETR3-like factor -- -- RNA-binding protein CUGBP1/BRUNO (RRM superfamily) A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- Q99LI7 Cleavage stimulation factor subunit 3 Cstf3 1318 1285.1 1296.8 1005.8 1008.5 1136.7 1.23767058076801 0.00486080870066979 0.307627376964631 Nonsignificant None 2 Cellular Component:nucleus (GO:0005634),Biological Process:mRNA processing (GO:0006397) cleavage stimulation factor subunit 3 -- ko03015 mRNA surveillance pathway mRNA cleavage and polyadenylation factor I complex, subunit RNA14 A RNA processing and modification ; IPR008847 [Suppressor of forked] -- -- Q69Z43 MKIAA1995 protein (Fragment) Nek9 425.1 427 390.2 400.7 378.3 419.6 1.0364592024028 0.43731316406763 0.0516633295206044 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) NIMA (never in mitosis gene a)-related kinase 9 2.7.11.1 -- FOG: RCC1 domain S Function unknown ; IPR000408 [Regulator of chromosome condensation, RCC1] ; IPR000719[Protein kinase domain] -- -- Q9Z103 Activity-dependent neuroprotector homeobox protein Adnp 658.7 706.5 658.9 737.8 684.9 681.9 0.961750451392189 0.328497784251521 -0.0562654932444748 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) -- -- -- -- -- -- IPR001356 [Homeobox domain] -- Homeobox G4V4Z2 Gag protein gag 807.7 809.6 795.7 759.2 805.4 792.4 1.02375901569792 0.265363714491338 0.0338761569655841 Nonsignificant None 5 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:structural molecule activity (GO:0005198),Molecular Function:zinc ion binding (GO:0008270),Cellular Component:viral capsid (GO:0019028),Biological Process:virion assembly (GO:0019068) -- -- -- -- -- -- IPR000840 [Gamma-retroviral matrix protein] ; IPR001878[Zinc finger, CCHC-type] ; IPR002079[Gag polyprotein, inner coat protein p12] ; IPR003036[Core shell protein Gag P30] -- -- Q09014 Neutrophil cytosol factor 1 Ncf1 404 522.9 428.9 303.7 333.4 304.3 1.44019545357977 0.0211513517385576 0.526264617761474 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:phosphatidylinositol binding (GO:0035091) neutrophil cytosolic factor 1 -- ko04062 Chemokine signaling pathway ko04145 Phagosome ko04380 Osteoclast differentiation ko04666 Fc gamma R-mediated phagocytosis ko04670 Leukocyte transendothelial migration ko05140 Leishmaniasis ko05418 Fluid shear stress and atherosclerosis NADPH oxidase C Energy production and conversion ; IPR001452 [SH3 domain] ; IPR001683[Phox homologous domain] ; IPR015039[NADPH oxidase subunit p47Phox, C-terminal] ; IPR032136[Neutrophil cytosol factor 1, C-terminal] -- -- Q9JK23 Proteasome assembly chaperone 1 Psmg1 1278.9 1281.4 1241.6 1143 1066.1 1188.3 1.11906163536822 0.023672760006187 0.16228949886234 Nonsignificant None 2 Cellular Component:endoplasmic reticulum (GO:0005783),Biological Process:proteasome assembly (GO:0043248) proteasome assembly chaperone 1 -- -- -- -- -- IPR016565 [Proteasome assembly chaperone 1] -- -- Q8R3Q6 Protein MIX23 Mix23 960 1002.1 805 791.9 856 838.8 1.1127598825753 0.211571005127413 0.154142313622414 Nonsignificant None -- -- -- -- -- Predicted component of DNA replication checkpoint response mechanism (S-M checkpoint) RD General function prediction only ; Cell cycle control, cell division, chromosome partitioning ; IPR019171 [Caffeine-induced death protein 2] -- -- Q9DCT1 1,5-anhydro-D-fructose reductase Akr1e2 1310.1 1322.8 1688.9 1493.9 1458.2 1661.6 0.936731907146108 0.522879263206292 -0.0942918875293082 Nonsignificant None -- -- 1,5-anhydro-D-fructose reductase 1.1.1.263 -- Aldo/keto reductase family proteins R General function prediction only ; IPR023210 [NADP-dependent oxidoreductase domain] -- -- Q3U5C8 Rho guanine nucleotide exchange factor 16 Arhgef16 1321.8 1216.2 1475.2 1404.7 1818.9 1454.1 0.85794300617825 0.215581599683088 -0.221046283333946 Nonsignificant None 3 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Molecular Function:protein binding (GO:0005515),Biological Process:regulation of Rho protein signal transduction (GO:0035023) Rho guanine nucleotide exchange factor 16 -- -- Putative guanine nucleotide exchange factor TIM T Signal transduction mechanisms ; IPR000219 [Dbl homology (DH) domain] ; IPR001452[SH3 domain] ; IPR001849[Pleckstrin homology domain] -- -- Q9JMG1 Endothelial differentiation-related factor 1 Edf1 2378.6 2400 1893.1 1697.8 1841.5 1731.2 1.26585712930462 0.0524675329935812 0.3401145844858 Nonsignificant None 1 Molecular Function:sequence-specific DNA binding (GO:0043565) putative transcription factor -- -- Transcription factor MBF1 K Transcription ; IPR001387 [Cro/C1-type helix-turn-helix domain] ; IPR013729[Multiprotein bridging factor 1, N-terminal] -- -- Q6A028 Switch-associated protein 70 Swap70 1732.2 1610.6 1541.9 1455.2 1587.6 1528.3 1.06860493097941 0.196602641136906 0.0957285794725903 Nonsignificant None -- -- switch-associated protein 70 -- -- -- -- -- IPR001849 [Pleckstrin homology domain] -- -- Q9CQ69 Cytochrome b-c1 complex subunit 8 Uqcrq 1944.2 1830.6 2412.6 2810.1 2655.5 2624.4 0.764820766378245 0.0275574892047478 -0.386806399047549 Nonsignificant None 1 Molecular Function:ubiquinol-cytochrome-c reductase activity (GO:0008121) ubiquinol-cytochrome c reductase subunit 8 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04260 Cardiac muscle contraction ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Ubiquinol cytochrome c reductase, subunit QCR8 C Energy production and conversion ; IPR004205 [Cytochrome b-c1 complex subunit 8] -- -- Q9CZX9 ER membrane protein complex subunit 4 Emc4 733.4 752.8 788 782.2 798.4 802 0.954503483589356 0.102151809013519 -0.0671776319381732 Nonsignificant None -- -- -- -- -- Predicted membrane protein S Function unknown ; IPR009445 [Protein of unknown function DUF1077, TMEM85] -- -- Q3U2B7 Phospholipid-transporting ATPase Atp11b 497.6 485.7 459.9 482.6 522.2 512.2 0.951351351351351 0.205383996866386 -0.071949841879015 Nonsignificant None 2 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:metal ion binding (GO:0046872) phospholipid-translocating ATPase 3.6.3.1 -- P-type ATPase R General function prediction only ; IPR008250 [P-type ATPase, A domain] ; IPR032631[P-type ATPase, N-terminal] -- -- Q78HU3 Multivesicular body subunit 12A Mvb12a 843 794.9 770.7 756.3 724.8 801.7 1.05510776239706 0.245215746262426 0.0773903547014247 Nonsignificant None 1 Cellular Component:ESCRT I complex (GO:0000813) ESCRT-I complex subunit MVB12 -- ko04144 Endocytosis Uncharacterized conserved protein S Function unknown ; IPR018798 [Multivesicular body subunit 12] -- -- E9PWB1 Pleckstrin homology-like domain family B member 1 Phldb1 677 719.1 707.5 744.1 761.6 741.3 0.936181575433912 0.0273456774514787 -0.0951397225865753 Nonsignificant None -- -- -- -- -- -- -- -- IPR001849 [Pleckstrin homology domain] -- -- Q9R0A0 Peroxisomal membrane protein PEX14 Pex14 605.5 623.9 673.1 669.8 735.3 634.8 0.932643757046914 0.268845884914334 -0.10060197638941 Nonsignificant None -- -- peroxin-14 -- ko04146 Peroxisome Peroxisomal membrane anchor protein (peroxin) MOU Cell wall/membrane/envelope biogenesis ; Posttranslational modification, protein turnover, chaperones ; Intracellular trafficking, secretion, and vesicular transport ; IPR006785 [Peroxisome membrane anchor protein Pex14p, N-terminal] -- -- H3BIX4 Neuroplastin (Fragment) Nptn 685.5 738.6 897.9 980 872.2 884.4 0.848498136373602 0.128718569694176 -0.237016603825982 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q91VJ4 Serine/threonine-protein kinase 38 Stk38 970.4 945.7 966 997.7 1030.4 983.3 0.95706315999203 0.0532686713881112 -0.0633139584722657 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) serine/threonine kinase 38 2.7.11.1 -- NDR and related serine/threonine kinases R General function prediction only ; IPR000719 [Protein kinase domain] ; IPR017892[Protein kinase, C-terminal] -- -- Q8BFP9 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial Pdk1 1062.7 1026.1 1180.3 1182.5 1216.1 1207.1 0.906647807637907 0.0778523285464874 -0.141385858190658 Nonsignificant None -- -- pyruvate dehydrogenase kinase isoform 1 2.7.11.2 ko04066 HIF-1 signaling pathway ko04360 Axon guidance ko05230 Central carbon metabolism in cancer Dehydrogenase kinase T Signal transduction mechanisms ; IPR003594 [Histidine kinase-like ATPase, C-terminal domain] ; IPR018955[Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal] -- -- Q8VI94 2-5-oligoadenylate synthase-like protein 1 Oasl1 363.7 329.5 313.5 502.7 462.4 542.8 0.667617215995756 0.00372395657672277 -0.582906936604685 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) 2'-5'-oligoadenylate synthase-like protein -- ko05165 Human papillomavirus infection -- -- -- IPR000626 [Ubiquitin domain] ; IPR018952[2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal] -- -- Q60520 Paired amphipathic helix protein Sin3a Sin3a 775.4 767 660.8 665.7 709.3 702.9 1.06030126570095 0.347847133133439 0.0844742391092971 Nonsignificant None -- -- paired amphipathic helix protein Sin3a -- ko04919 Thyroid hormone signaling pathway ko05016 Huntington's disease ko05202 Transcriptional misregulation in cancer Histone deacetylase complex, SIN3 component B Chromatin structure and dynamics ; IPR003822 [Paired amphipathic helix] ; IPR013194[Histone deacetylase interacting domain] ; IPR031693[Sin3, C-terminal] -- -- Q3TXJ7 BCL domain-containing protein Bax 379.6 374.6 323.1 359.8 398.9 394.2 0.934426229508197 0.313254674829214 -0.0978473233981445 Nonsignificant None 1 Biological Process:regulation of apoptotic process (GO:0042981) apoptosis regulator BAX -- ko01521 EGFR tyrosine kinase inhibitor resistance ko01522 Endocrine resistance ko01524 Platinum drug resistance ko04071 Sphingolipid signaling pathway ko04115 p53 signaling pathway ko04141 Protein processing in endoplasmic reticulum ko04210 Apoptosis ko04211 Longevity regulating pathway ko04215 Apoptosis - multiple species ko04217 Necroptosis ko04722 Neurotrophin signaling pathway ko04932 Non-alcoholic fatty liver disease (NAFLD) ko04933 AGE-RAGE signaling pathway in diabetic complications ko05014 Amyotrophic lateral sclerosis (ALS) ko05016 Huntington's disease ko05020 Prion diseases ko05152 Tuberculosis ko05161 Hepatitis B ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05200 Pathways in cancer ko05202 Transcriptional misregulation in cancer ko05203 Viral carcinogenesis ko05210 Colorectal cancer ko05212 Pancreatic cancer ko05213 Endometrial cancer ko05214 Glioma ko05216 Thyroid cancer ko05217 Basal cell carcinoma ko05218 Melanoma ko05220 Chronic myeloid leukemia ko05222 Small cell lung cancer ko05223 Non-small cell lung cancer ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer -- -- -- IPR026298 [Blc2 family] -- -- H9KV21 RBR-type E3 ubiquitin transferase Arih1 1612 1818.3 1750.7 1695.2 1698.5 1700.3 1.0170789163722 0.680080254402711 0.0244316239758856 Nonsignificant None -- -- ariadne-1 2.3.2.27 -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR002867 [IBR domain] -- -- Q99LB6 Methionine adenosyltransferase 2 subunit beta Mat2b 1313 1308 1524.1 1599.1 1626.4 1574.6 0.863544509489386 0.0399279083950416 -0.21165755469575 Nonsignificant None -- -- S-adenosylmethionine synthetase 2.5.1.6 ko00270 Cysteine and methionine metabolism ko01100 Metabolic pathways ko01230 Biosynthesis of amino acids C-3 sterol dehydrogenase/3-beta-hydroxysteroid dehydrogenase and related dehydrogenases IE Lipid transport and metabolism ; Amino acid transport and metabolism ; IPR029903 [RmlD-like substrate binding domain] -- -- Q791T5 Mitochondrial carrier homolog 1 Mtch1 1005.9 947 859.4 1030.1 1054 1100.7 0.883038181361467 0.0586272729176892 -0.179452275507454 Nonsignificant None -- -- mitochondrial carrier -- -- Mitochondrial carrier protein R General function prediction only ; IPR018108 [Mitochondrial substrate/solute carrier] -- -- Q9D898 Actin-related protein 2/3 complex subunit 5-like protein Arpc5l 1276.9 1280.9 1394.9 1347.4 1372.3 1409.1 0.957348382096493 0.240595179464784 -0.0628840733512681 Nonsignificant None 4 Cellular Component:Arp2/3 protein complex (GO:0005885),Cellular Component:actin cytoskeleton (GO:0015629),Biological Process:regulation of actin filament polymerization (GO:0030833),Biological Process:Arp2/3 complex-mediated actin nucleation (GO:0034314) actin related protein 2/3 complex, subunit 5 -- ko04144 Endocytosis ko04666 Fc gamma R-mediated phagocytosis ko04810 Regulation of actin cytoskeleton ko05100 Bacterial invasion of epithelial cells ko05132 Salmonella infection Actin-related protein Arp2/3 complex, subunit ARPC5 Z Cytoskeleton ; IPR006789 [Actin-related protein 2/3 complex subunit 5] -- -- Q8C8U0 Liprin-beta-1 Ppfibp1 596.5 644.2 682.5 645.8 700.1 632.8 0.971951281144186 0.597521532353698 -0.0410440940328478 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- LAR transmembrane tyrosine phosphatase-interacting protein liprin R General function prediction only ; IPR001660 [Sterile alpha motif domain] -- -- F8WHP8 ATP synthase subunit f, mitochondrial Atp5j2 750.7 785.7 943.2 1057.5 1072.9 1000.9 0.791875578833073 0.0262541922396847 -0.336654326074423 Nonsignificant None -- -- F-type H+-transporting ATPase subunit f -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways Mitochondrial F1F0-ATP synthase, subunit f C Energy production and conversion ; IPR019344 [Mitochondrial F1-F0 ATP synthase subunit F, predicted] -- -- Q63829 COMM domain-containing protein 3 Commd3 1799.6 1820.3 1799.4 1616.8 1706.4 1701.7 1.07848912416167 0.011758831037666 0.109011627961389 Nonsignificant None -- -- -- -- -- -- -- -- IPR017920 [COMM domain] -- -- Q05117 Tartrate-resistant acid phosphatase type 5 Acp5 622.4 614.7 614.3 718 774.3 742.9 0.828292770221904 0.0014910771667588 -0.271787298791867 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) tartrate-resistant acid phosphatase type 5 3.1.3.2 ko00740 Riboflavin metabolism ko01100 Metabolic pathways ko04142 Lysosome ko04380 Osteoclast differentiation ko05323 Rheumatoid arthritis Purple (tartrate-resistant) acid phosphatase O Posttranslational modification, protein turnover, chaperones ; IPR004843 [Calcineurin-like phosphoesterase domain, ApaH type] -- -- Q9ER38 Torsin-3A Tor3a 491.9 459.8 445.4 503.1 545 497.4 0.903979294726626 0.0719151334100169 -0.145638366204101 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) -- -- -- ATPase of the AAA+ superfamily R General function prediction only ; IPR010448 [Torsin] -- -- Q9DAU1 Protein canopy homolog 3 Cnpy3 1233 1303.8 1247.4 1224.2 1163.3 1208.4 1.05236519369282 0.0906481326773363 0.0736354381877357 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR021852 [Domain of unknown function DUF3456] -- -- H3BK24 Homeobox protein cut-like Cux1 34.1 26.2 33.5 39.1 33.1 38.5 0.847335140018067 0.150796538693747 -0.238995394266176 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) homeobox protein cut-like -- -- Transcription factor/CCAAT displacement protein CDP1 K Transcription ; IPR001356 [Homeobox domain] ; IPR003350[CUT domain] -- CUT Q9CWU9 Nucleoporin Nup37 Nup37 1006.4 1000.9 864.1 785.4 862.8 857.3 1.14603871482738 0.0820413668019041 0.196655781220516 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) nuclear pore complex protein Nup37 -- ko03013 RNA transport WD40 repeat-containing protein R General function prediction only ; IPR001680 [WD40 repeat] -- -- G3UW81 Cytochrome P450, family 4, subfamily f, polypeptide 40 Cyp4f40 307.9 274.8 242.6 273.9 280.8 264.6 1.00732332478945 0.922956363294126 0.0105268255509242 Nonsignificant None 3 Molecular Function:iron ion binding (GO:0005506),Molecular Function:heme binding (GO:0020037),Biological Process:oxidation-reduction process (GO:0055114) cytochrome P450 family 4 subfamily F 1.14.14.1 -- Cytochrome P450 CYP4/CYP19/CYP26 subfamilies QI Secondary metabolites biosynthesis, transport and catabolism ; Lipid transport and metabolism ; IPR001128 [Cytochrome P450] -- -- E9QJS7 Adhesion G protein-coupled receptor E5 Adgre5 704.1 699.9 609.4 602.2 649 672.4 1.04668330214182 0.465559499908769 0.0658249880710139 Nonsignificant None 5 Molecular Function:G-protein coupled receptor activity (GO:0004930),Molecular Function:calcium ion binding (GO:0005509),Biological Process:G-protein coupled receptor signaling pathway (GO:0007186),Cellular Component:membrane (GO:0016020),Cellular Component:integral component of membrane (GO:0016021) CD97 antigen -- -- G protein-coupled receptors T Signal transduction mechanisms ; IPR000203 [GPS motif] ; IPR000832[GPCR, family 2, secretin-like] ; IPR001881[EGF-like calcium-binding domain] -- -- Q7M084 Kininogen, LMW (Fragment) 286.8 316.8 223.4 121.9 152.5 155.6 1.92325581395349 0.0110129377682377 0.943550669581814 Significant up -- -- kininogen -- ko04610 Complement and coagulation cascades -- -- -- -- -- -- Q9DBR3 Armadillo repeat-containing protein 8 Armc8 432.3 414.5 392.3 395 367.1 412.6 1.05482250787435 0.289294440308133 0.0770002609683719 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Proteins containing armadillo/beta-catenin-like repeat R General function prediction only ; IPR000225 [Armadillo] -- -- Q6ZWR0 Ras-related protein Rap-2 Rap2b 75.9 81.9 76.4 65.5 81.7 81.2 1.02539404553415 0.749659624657412 0.0361784251383723 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rap-2B -- -- Ras-related GTPase R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- D0EW11 Multiple coagulation factor deficiency 2 isoform 1 Mcfd2 182.4 179.2 377 380.4 375.7 341.2 0.67310671648592 0.146874106633002 -0.571092842444385 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) multiple coagulation factor deficiency protein 2 -- -- Uncharacterized conserved protein S Function unknown ; IPR002048 [EF-hand domain] -- -- Q3UTI7 Peptidyl-prolyl cis-trans isomerase Pin1 1439.9 1395.6 1160.8 977.1 992.5 1044.4 1.32591240875912 0.0211914239324506 0.406985472567596 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:isomerase activity (GO:0016853) peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 5.2.1.8 ko04622 RIG-I-like receptor signaling pathway Peptidyl-prolyl cis-trans isomerase O Posttranslational modification, protein turnover, chaperones ; IPR000297 [Peptidyl-prolyl cis-trans isomerase, PpiC-type] ; IPR001202[WW domain] -- -- Q62425 Cytochrome c oxidase subunit NDUFA4 Ndufa4 2273 2297.2 2688.7 2691 2411 2459.4 0.959994180971778 0.5628665267855 -0.0589024339583629 Nonsignificant None -- -- NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 4 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease -- -- -- IPR010530 [NADH-ubiquinone reductase complex 1 MLRQ subunit] -- -- Q5XK38 Hmgn2 protein Hmgn2 2243.4 2325.7 868.5 942.9 884.1 933.1 1.97007354805985 0.19940878450001 0.978249490311376 Nonsignificant None 3 Cellular Component:chromatin (GO:0000785),Cellular Component:nucleus (GO:0005634),Molecular Function:nucleosomal DNA binding (GO:0031492) high-mobility group nucleosome-binding domain-containing protein 2 -- -- -- -- -- IPR000079 [High mobility group protein HMGN] -- -- Q91YM4 FAST kinase domain-containing protein 4 Tbrg4 675 605.2 599 637.4 683.4 699.1 0.930343086291401 0.200139196370492 -0.10416525219985 Nonsignificant None 1 Molecular Function:protein kinase activity (GO:0004672) -- -- -- -- -- -- IPR010622 [FAST kinase leucine-rich] ; IPR013579[FAST kinase-like protein, subdomain 2] ; IPR013584[RAP domain] -- -- Q60949 TBC1 domain family member 1 Tbc1d1 254.7 243.3 233.8 257.3 241.4 231.2 1.00260309631456 0.951095407868386 0.00375059467950172 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) TBC1 domain family member 1 -- ko04152 AMPK signaling pathway Predicted GTPase activator NB4S/EVI5 (contains TBC domain)/Calmodulin-binding protein Pollux (contains PTB and TBC domains) R General function prediction only ; IPR000195 [Rab-GTPase-TBC domain] ; IPR006020[PTB/PI domain] ; IPR021785[Domain of unknown function DUF3350] -- -- E9Q1M6 Ankyrin repeat and KH domain-containing 1 Ankhd1 181.4 207.7 100.6 433.5 553.7 209.8 0.409106098579783 0.0897475932974423 -1.2894530511221 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) ankyrin repeat domain-containing protein 17 -- -- RTK signaling protein MASK/UNC-44 T Signal transduction mechanisms ; IPR004088 [K Homology domain, type 1] ; IPR020683[Ankyrin repeat-containing domain] -- -- P60898 DNA-directed RNA polymerase II subunit RPB9 Polr2i 277.8 331.1 310.7 328.3 294.2 298.9 0.998046451052746 0.97611913337849 -0.00282113188603082 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:zinc ion binding (GO:0008270) DNA-directed RNA polymerase II subunit RPB9 -- ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways ko03020 RNA polymerase ko05016 Huntington's disease ko05169 Epstein-Barr virus infection RNA polymerase II subunit 9 K Transcription ; IPR001222 [Zinc finger, TFIIS-type] ; IPR001529[DNA-directed RNA polymerase, M/15kDa subunit] -- -- Q545J0 Regenerating islet-derived 2 Reg2 1058 718.9 1106.4 299.6 474.4 364.6 2.53232039346566 0.0116824761934331 1.34045994853471 Significant up -- -- -- -- -- C-type lectin TV Signal transduction mechanisms ; Defense mechanisms ; IPR001304 [C-type lectin-like] -- -- P19426 Negative elongation factor E Nelfe 378.4 403.4 359.7 347.4 349.2 352.1 1.08849051206255 0.13290343052932 0.122328832183943 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) negative elongation factor E -- -- -- -- -- IPR000504 [RNA recognition motif domain] -- -- Q7TSE6 Serine/threonine-protein kinase 38-like Stk38l 474.3 481.5 429.2 509 550 529.8 0.871727089627392 0.0282138748456412 -0.198051551704461 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) serine/threonine kinase 38 2.7.11.1 -- NDR and related serine/threonine kinases R General function prediction only ; IPR000719 [Protein kinase domain] ; IPR017892[Protein kinase, C-terminal] -- -- Q541Z2 Uncharacterized protein Fnta 682.9 725.1 829.2 973.1 935.3 929.2 0.788412743163237 0.0117853441103742 -0.342976999949608 Nonsignificant None 2 Molecular Function:protein prenyltransferase activity (GO:0008318),Biological Process:protein prenylation (GO:0018342) -- -- ko00900 Terpenoid backbone biosynthesis Protein farnesyltransferase, alpha subunit/protein geranylgeranyltransferase type I, alpha subunit O Posttranslational modification, protein turnover, chaperones ; IPR002088 [Protein prenyltransferase, alpha subunit] -- -- Q3U2G9 N-acetyl-D-glucosamine kinase Nagk 881.4 852.2 1119.1 1200.6 1171.2 1229.3 0.792174613312599 0.0443366575484589 -0.336109626710815 Nonsignificant None -- -- N-acetylglucosamine kinase 2.7.1.59 ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways N-Acetylglucosamine kinase G Carbohydrate transport and metabolism ; IPR002731 [ATPase, BadF/BadG/BcrA/BcrD type] -- -- Q9CYA6 Zinc finger CCHC domain-containing protein 8 Zcchc8 429.6 436.3 416 435.3 424.5 428 0.995418543252058 0.785765077419747 -0.00662483223589627 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:zinc ion binding (GO:0008270) zinc finger CCHC domain-containing protein 8 -- -- Uncharacterized conserved protein, contains PSP domain S Function unknown ; IPR001878 [Zinc finger, CCHC-type] ; IPR006568[PSP, proline-rich] -- -- A2AB60 Formin-like protein 1 Fmnl1 627.7 675.6 504.4 465.3 488 464.1 1.27536334132919 0.122262048431651 0.350908318501943 Nonsignificant None 4 Molecular Function:actin binding (GO:0003779),Biological Process:cellular component organization (GO:0016043),Molecular Function:Rho GTPase binding (GO:0017048),Biological Process:actin cytoskeleton organization (GO:0030036) -- -- -- Rac1 GTPase effector FRL TZ Signal transduction mechanisms ; Cytoskeleton ; IPR010472 [Formin, FH3 domain] ; IPR010473[Formin, GTPase-binding domain] ; IPR015425[Formin, FH2 domain] -- -- Q3UCF3 Uncharacterized protein AA467197 401.5 327.8 411.9 610.8 671.6 705.9 0.573957652265755 0.0018201551260622 -0.80098379896198 Significant down -- -- -- -- -- -- -- -- IPR010530 [NADH-ubiquinone reductase complex 1 MLRQ subunit] -- -- Q8R5J9 PRA1 family protein 3 Arl6ip5 816.5 895.9 1074.3 934 948.5 938.5 0.987841191066997 0.894620954288746 -0.0176489673239803 Nonsignificant None -- -- PRA1 family protein 3 -- -- Glutamate transporter EAAC1-interacting protein GTRAP3-18 ET Amino acid transport and metabolism ; Signal transduction mechanisms ; IPR004895 [Prenylated rab acceptor PRA1] -- -- F8VPM7 ELKS/Rab6-interacting/CAST family member 1 Erc1 1250 1208.2 1254.3 1277.9 1289.9 1244 0.973949315284118 0.175388462577554 -0.0380813990590917 Nonsignificant None 1 Cellular Component:presynaptic active zone (GO:0048786) ELKS/RAB6-interacting/CAST family member 2 -- -- Rab6 GTPase-interacting protein involved in endosome-to-TGN transport U Intracellular trafficking, secretion, and vesicular transport ; IPR019018 [Rab-binding domain FIP-RBD] ; IPR019323[Active zone protein ELKS] -- -- A0A0A0MQD2 Y-box-binding protein 2 Ybx2 16.2 11.2 11.5 12.4 22.8 21.8 0.682456140350877 0.177106893039716 -0.551191764065912 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) Y-box-binding protein 2 -- -- Predicted RNA-binding protein containing PIN domain and invovled in translation or RNA processing J Translation, ribosomal structure and biogenesis ; IPR002059 [Cold-shock protein, DNA-binding] -- CSD Q8CG72 ADP-ribosylhydrolase ARH3 Adprs 379.9 373.3 430 455.3 460 494.6 0.839208454500319 0.0255638019841276 -0.252898882648727 Nonsignificant None -- -- poly(ADP-ribose) glycohydrolase ARH3 3.2.1.143 -- -- -- -- IPR005502 [ADP-ribosylation/Crystallin J1] -- -- Q6ZWV7 60S ribosomal protein L35 Rpl35 4209.9 4295.4 2514.5 2106.7 2210.8 2307.5 1.66336603773585 0.126043533870517 0.73410568078255 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L35e -- ko03010 Ribosome 60S ribosomal protein L35 J Translation, ribosomal structure and biogenesis ; IPR001854 [Ribosomal protein L29] -- -- Q9WVL2 Signal transducer and activator of transcription 2 Stat2 629 672.4 824 680.4 761.2 643.5 1.01932761018656 0.854234184303326 0.0276178058023049 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Biological Process:signal transduction (GO:0007165) signal transducer and activator of transcription 2 -- ko04062 Chemokine signaling pathway ko04217 Necroptosis ko04380 Osteoclast differentiation ko04621 NOD-like receptor signaling pathway ko04630 Jak-STAT signaling pathway ko05160 Hepatitis C ko05161 Hepatitis B ko05162 Measles ko05164 Influenza A ko05165 Human papillomavirus infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection ko05200 Pathways in cancer STAT protein KT Transcription ; Signal transduction mechanisms ; IPR000980 [SH2 domain] ; IPR013799[STAT transcription factor, protein interaction] ; IPR013800[STAT transcription factor, all-alpha domain] ; IPR013801[STAT transcription factor, DNA-binding] ; IPR022756[Signal transducer and activation of transcription 2, C-terminal] -- STAT Q923D4 Splicing factor 3B subunit 5 Sf3b5 1266.4 1211.5 1261.9 1207.9 1210.7 1261.1 1.01633285322173 0.462278661451539 0.0233729681032589 Nonsignificant None -- -- splicing factor 3B subunit 5 -- ko03040 Spliceosome Uncharacterized conserved protein S Function unknown ; IPR009846 [Splicing factor 3B subunit 5/RDS3 complex subunit 10] -- -- Q9DD03 Ras-related protein Rab-13 Rab13 165.2 151.3 169.8 176.1 167.1 203.7 0.889193636862315 0.176856034818087 -0.169430470521593 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-13 -- ko04530 Tight junction GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- Q3TU26 Ras-related protein Rab-3 Rab3c 95.7 83.4 116.2 132.3 129 140.5 0.734942757590841 0.0250233188321457 -0.444296207599338 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-3C -- -- GTPase Rab3, small G protein superfamily U Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- P35585 AP-1 complex subunit mu-1 Ap1m1 202.4 194.6 195.9 168.7 190.3 185.9 1.08808955771701 0.0848002067039701 0.121797305813275 Nonsignificant None -- -- AP-1 complex subunit mu -- ko04142 Lysosome Adaptor complexes medium subunit family U Intracellular trafficking, secretion, and vesicular transport ; IPR022775 [AP complex, mu/sigma subunit] ; IPR028565[Mu homology domain] -- -- Q8C7E9 Cleavage stimulation factor subunit 2 tau variant Cstf2t 38 43.6 51.1 49.5 42.3 46.2 0.961594202898551 0.704032803379152 -0.0564998962953379 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Biological Process:mRNA 3'-end processing (GO:0031124) cleavage stimulation factor subunit 2 -- ko03015 mRNA surveillance pathway mRNA cleavage and polyadenylation factor I complex, subunit RNA15 A RNA processing and modification ; IPR000504 [RNA recognition motif domain] ; IPR025742[Cleavage stimulation factor subunit 2, hinge domain] ; IPR026896[Transcription termination and cleavage factor, C-terminal domain] -- -- Q9WVL0 Maleylacetoacetate isomerase Gstz1 1404.5 1488.4 1310.9 1248 1200.8 1328.5 1.11291133878696 0.0883427358804579 0.154338663490911 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) maleylacetoacetate isomerase 5.2.1.2 ko00350 Tyrosine metabolism ko01100 Metabolic pathways Glutathione S-transferase O Posttranslational modification, protein turnover, chaperones ; IPR004045 [Glutathione S-transferase, N-terminal] ; IPR004046[Glutathione S-transferase, C-terminal] -- -- A0A1L1SSF2 ADP-dependent glucokinase Adpgk 723.6 804.5 715.7 648.8 684.1 657.7 1.12719782980006 0.0494946570555679 0.172740739134473 Nonsignificant None 1 Biological Process:carbohydrate metabolic process (GO:0005975) ADP-dependent glucokinase 2.7.1.147 ko00010 Glycolysis / Gluconeogenesis ko01100 Metabolic pathways ko01200 Carbon metabolism Predicted sugar kinase GR Carbohydrate transport and metabolism ; General function prediction only ; IPR007666 [ADP-specific phosphofructokinase/glucokinase] -- -- Q8VDK4 Cadherin-13 Cdh13 365 523.4 682.5 759.8 773 652 0.719013181984621 0.108471177999015 -0.475909874418183 Nonsignificant None 3 Molecular Function:calcium ion binding (GO:0005509),Biological Process:homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156),Cellular Component:membrane (GO:0016020) cadherin 13, H-cadherin -- -- FOG: Cadherin repeats S Function unknown ; IPR002126 [Cadherin] ; IPR014868[Cadherin prodomain] -- -- P51437 Cathelicidin antimicrobial peptide Camp 409.8 730 393.2 132.3 145 121.9 3.84018036072144 0.074259445049544 1.94117407120888 Nonsignificant None 1 Biological Process:defense response to bacterium (GO:0042742) cathelicidin antimicrobial peptide -- ko04621 NOD-like receptor signaling pathway ko04970 Salivary secretion ko05152 Tuberculosis -- -- -- IPR022746 [Cathelicidin, antimicrobial peptide, C-terminal] -- -- Q05144 Ras-related C3 botulinum toxin substrate 2 Rac2 1003.4 1342.1 1025.7 717 831.5 708.8 1.49346564479688 0.0331532614622032 0.578664050737929 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related C3 botulinum toxin substrate 2 -- ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04024 cAMP signaling pathway ko04062 Chemokine signaling pathway ko04071 Sphingolipid signaling pathway ko04310 Wnt signaling pathway ko04360 Axon guidance ko04370 VEGF signaling pathway ko04510 Focal adhesion ko04520 Adherens junction ko04650 Natural killer cell mediated cytotoxicity ko04662 B cell receptor signaling pathway ko04664 Fc epsilon RI signaling pathway ko04666 Fc gamma R-mediated phagocytosis ko04670 Leukocyte transendothelial migration ko04810 Regulation of actin cytoskeleton ko05200 Pathways in cancer ko05210 Colorectal cancer ko05212 Pancreatic cancer ko05231 Choline metabolism in cancer ko05416 Viral myocarditis ko05418 Fluid shear stress and atherosclerosis Ras-related small GTPase, Rho type R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- Q9JLI2 Collagen type V alpha 3 chain Col5a3 288.4 279.8 266.5 339.7 339.3 308.4 0.845351427992708 0.0138838161561432 -0.242376874176064 Nonsignificant None 1 Molecular Function:extracellular matrix structural constituent (GO:0005201) collagen, type V/XI/XXIV/XXVII, alpha -- ko04974 Protein digestion and absorption Collagens (type IV and type XIII), and related proteins W Extracellular structures ; IPR000885 [Fibrillar collagen, C-terminal] ; IPR008160[Collagen triple helix repeat] -- -- B2RTB0 PDGFA associated protein 1 Pdap1 620.1 643.4 869.9 808.4 811.3 731.4 0.90740504444728 0.435639206469769 -0.140181414944301 Nonsignificant None -- -- -- -- -- Phosphoprotein/predicted coiled-coil protein R General function prediction only ; IPR019380 [Casein kinase substrate, phosphoprotein PP28] -- -- Q3UGW4 ATP-dependent Clp protease proteolytic subunit (Fragment) Clpp 579.8 599 674 690.8 684.7 682 0.900510328068044 0.139758482917795 -0.151185272207114 Nonsignificant None -- -- ATP-dependent Clp protease, protease subunit 3.4.21.92 ATP-dependent Clp protease, proteolytic subunit O Posttranslational modification, protein turnover, chaperones ; IPR023562 [Clp protease proteolytic subunit /Translocation-enhancing protein TepA] -- -- O89020 Afamin Afm 666.6 651.6 536.3 440.6 473.8 438 1.37126589766341 0.0173132100812802 0.455508346496995 Nonsignificant None 1 Cellular Component:extracellular space (GO:0005615) -- -- -- -- -- -- IPR014760 [Serum albumin, N-terminal] -- -- Q6ZQL4 WD repeat-containing protein 43 Wdr43 1005.8 1044 1217.4 980 984.2 977.9 1.11049930321879 0.237865273933613 0.151208487668223 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) U3 small nucleolar RNA-associated protein 5 -- ko03008 Ribosome biogenesis in eukaryotes WD40 repeat-containing protein R General function prediction only ; IPR001680 [WD40 repeat] ; IPR007148[Small-subunit processome, Utp12] -- -- Q8BYL4 Tyrosine--tRNA ligase, mitochondrial Yars2 310.5 303.1 301.4 301 283.2 292.1 1.04416295789113 0.0920722786282155 0.0623468845084322 Nonsignificant None 4 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation for protein translation (GO:0006418) tyrosyl-tRNA synthetase 6.1.1.1 ko00970 Aminoacyl-tRNA biosynthesis Tyrosyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR002305 [Aminoacyl-tRNA synthetase, class Ic] -- -- Q99J83 Autophagy protein 5 Atg5 1134.2 1029.7 1086.1 1119.6 1148 1187.8 0.940556809631302 0.130746360851999 -0.0884130097267251 Nonsignificant None 2 Cellular Component:cytoplasm (GO:0005737),Biological Process:autophagy (GO:0006914) autophagy-related protein 5 -- ko04136 Autophagy - other ko04137 Mitophagy - animal ko04140 Autophagy - animal ko04211 Longevity regulating pathway ko04213 Longevity regulating pathway - multiple species ko04216 Ferroptosis ko04621 NOD-like receptor signaling pathway ko04622 RIG-I-like receptor signaling pathway Protein involved in autophagy and nutrient starvation O Posttranslational modification, protein turnover, chaperones ; IPR007239 [Autophagy-related protein 5] -- -- Q9WTL7 Acyl-protein thioesterase 2 Lypla2 2624 2628.6 2726.4 2899.7 2951 3092.1 0.892226148409894 0.00846023502550951 -0.164518665192725 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) lysophospholipase II 3.1.1.5 ko00564 Glycerophospholipid metabolism Lysophospholipase I Lipid transport and metabolism ; IPR003140 [Phospholipase/carboxylesterase/thioesterase] -- -- Q80X31 Sodium/hydrogen exchanger Slc9a1 523.2 495.2 534.1 555 568.4 550 0.927751882395124 0.034743797462425 -0.108189071754262 Nonsignificant None 4 Biological Process:cation transport (GO:0006812),Molecular Function:solute:proton antiporter activity (GO:0015299),Cellular Component:integral component of membrane (GO:0016021),Biological Process:transmembrane transport (GO:0055085) solute carrier family 9 (sodium/hydrogen exchanger), member 1 -- ko04024 cAMP signaling pathway ko04260 Cardiac muscle contraction ko04261 Adrenergic signaling in cardiomyocytes ko04371 Apelin signaling pathway ko04810 Regulation of actin cytoskeleton ko04919 Thyroid hormone signaling pathway ko04970 Salivary secretion ko04971 Gastric acid secretion ko04972 Pancreatic secretion ko04976 Bile secretion ko05205 Proteoglycans in cancer Sodium/hydrogen exchanger protein P Inorganic ion transport and metabolism ; IPR006153 [Cation/H+ exchanger] ; IPR032103[Sodium/hydrogen exchanger, regulatory region] -- -- A0A498WFS2 UBX domain-containing protein 1 Ubxn1 795.6 774.3 871 889.4 901.6 883.6 0.912622448216556 0.0592234286521009 -0.131909953998392 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Predicted ubiquitin regulatory protein O Posttranslational modification, protein turnover, chaperones ; IPR001012 [UBX domain] -- -- Q99LJ6 Glutathione peroxidase 7 Gpx7 2564.4 2539.9 2648.6 2216.2 2166.3 2262.3 1.16676197929208 0.00101229630349366 0.222510279709645 Nonsignificant None 3 Molecular Function:glutathione peroxidase activity (GO:0004602),Biological Process:response to oxidative stress (GO:0006979),Biological Process:oxidation-reduction process (GO:0055114) glutathione peroxidase 1.11.1.9 ko00480 Glutathione metabolism ko00590 Arachidonic acid metabolism ko04918 Thyroid hormone synthesis Glutathione peroxidase O Posttranslational modification, protein turnover, chaperones ; IPR000889 [Glutathione peroxidase] -- -- Q99N96 39S ribosomal protein L1, mitochondrial Mrpl1 689.7 665.4 664.4 672.7 731.2 682.1 0.968120805369127 0.328476684539207 -0.0467410118166793 Nonsignificant None -- -- large subunit ribosomal protein L1 -- ko03010 Ribosome 50S ribosomal protein L1 J Translation, ribosomal structure and biogenesis ; IPR028364 [Ribosomal protein L1/ribosomal biogenesis protein] -- -- P11034 Mast cell protease 1 Mcpt1 613.5 643.1 599.5 573.3 630.6 613.8 1.02112559828355 0.580550790860219 0.0301603283866951 Nonsignificant None 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) mast cell peptidase 1 3.4.21.- -- Trypsin E Amino acid transport and metabolism ; IPR001254 [Serine proteases, trypsin domain] -- -- Q8R3P6 Integrator complex subunit 14 Ints14 491.4 475.2 420.1 499.9 492.8 453.9 0.958592561869211 0.483550831732418 -0.0610103493765917 Nonsignificant None -- -- -- -- -- -- -- -- IPR002035 [von Willebrand factor, type A] -- -- Q8CJ53 Cdc42-interacting protein 4 Trip10 1133 1067.9 1078.1 1262.9 1394.2 1298.6 0.828930404226812 0.00691168314097427 -0.270677114627947 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) thyroid hormone receptor interactor 10 -- ko04910 Insulin signaling pathway Cdc42-interacting protein CIP4 Z Cytoskeleton ; IPR001060 [FCH domain] ; IPR001452[SH3 domain] -- -- E9Q179 G-rich sequence factor 1 Grsf1 665.1 657.8 577.5 620.4 614.6 614.4 1.02757651130096 0.606537671840783 0.0392458181064122 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- Splicing factor hnRNP-F and related RNA-binding proteins A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- Q9DBC9 Threonine aldolase 1 Tha1 244.7 215.6 220.4 224.3 219.7 246.4 0.985950173812283 0.804216092617385 -0.0204133547854614 Nonsignificant None 2 Biological Process:cellular amino acid metabolic process (GO:0006520),Molecular Function:lyase activity (GO:0016829) threonine aldolase 4.1.2.48 ko00260 Glycine, serine and threonine metabolism ko01100 Metabolic pathways ko01230 Biosynthesis of amino acids Threonine aldolase E Amino acid transport and metabolism ; IPR001597 [Aromatic amino acid beta-eliminating lyase/threonine aldolase] -- -- Q9D0M0 Exosome complex exonuclease RRP42 Exosc7 951 1074.4 1148.5 1009.3 1005.8 981.9 1.05902569235903 0.413974255547946 0.0827375900756047 Nonsignificant None -- -- exosome complex component RRP42 -- ko03018 RNA degradation Exosomal 3'-5' exoribonuclease complex, subunit Rrp42 J Translation, ribosomal structure and biogenesis ; IPR001247 [Exoribonuclease, phosphorolytic domain 1] ; IPR015847[Exoribonuclease, phosphorolytic domain 2] -- -- P50171 (3R)-3-hydroxyacyl-CoA dehydrogenase Hsd17b8 458 441.5 497.6 553.8 539.5 554.3 0.84796067006555 0.00854915298433718 -0.237930743326772 Nonsignificant None -- -- -- -- ko00140 Steroid hormone biosynthesis ko01100 Metabolic pathways Mitochondrial/plastidial beta-ketoacyl-ACP reductase I Lipid transport and metabolism ; -- -- -- Q61351 Biliary glycoprotein Ceacam1 152.6 156.6 214 178.9 200.4 159.5 0.971046770601336 0.832818336150886 -0.0423873099642205 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) carcinoembryonic antigen-related cell adhesion molecule -- -- -- -- -- IPR007110 [Immunoglobulin-like domain] ; IPR013106[Immunoglobulin V-set domain] -- -- Q8BGS2 BolA-like protein 2 Bola2 1333 1459.2 1257.3 1141.8 1147.8 1067.2 1.20635724499523 0.0229897716787097 0.270657203475189 Nonsignificant None -- -- -- -- -- BolA (bacterial stress-induced morphogen)-related protein T Signal transduction mechanisms ; IPR002634 [BolA protein] -- -- Q91V47 Ubiquitin-like protein 4A (Fragment) DXS254E 2272.9 2379.6 2102.7 1777 1817.2 1812.7 1.24936655014888 0.0282127241859081 0.321196809611603 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Ubiquitin and ubiquitin-like proteins OR Posttranslational modification, protein turnover, chaperones ; General function prediction only ; IPR000626 [Ubiquitin domain] -- -- P59017 Bcl-2-like protein 13 Bcl2l13 512.6 485.7 613.5 552.6 587 591.5 0.931084281670614 0.384844936860007 -0.10301632855895 Nonsignificant None 1 Biological Process:regulation of apoptotic process (GO:0042981) Bcl-2-like protein 13 -- ko04137 Mitophagy - animal ko05134 Legionellosis -- -- -- IPR026298 [Blc2 family] -- -- Q71V27 Smooth muscle LIM protein Csrp2 1515.8 1414.8 1430.4 1382.8 1331.6 1409 1.05762235048746 0.110494732103543 0.0808245704195772 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) cysteine and glycine-rich protein -- -- Regulatory protein MLP and related LIM proteins TZ Signal transduction mechanisms ; Cytoskeleton ; IPR001781 [Zinc finger, LIM-type] -- -- Q9CR09 Ubiquitin-fold modifier-conjugating enzyme 1 Ufc1 2163.2 2214.5 1820.2 1927.6 1919 1882.1 1.08190339867684 0.333377223326324 0.113571689117064 Nonsignificant None -- -- ufm1-conjugating enzyme 1 -- -- Uncharacterized conserved protein S Function unknown ; IPR014806 [Ubiquitin-fold modifier-conjugating enzyme 1] -- -- Q4G0C5 Peptidyl-prolyl cis-trans isomerase Ppih 1493 1499.8 1599.1 1442.2 1528.7 1429.4 1.04354248573961 0.240294316584639 0.0614893381288877 Nonsignificant None 3 Biological Process:protein peptidyl-prolyl isomerization (GO:0000413),Molecular Function:peptidyl-prolyl cis-trans isomerase activity (GO:0003755),Biological Process:protein folding (GO:0006457) peptidyl-prolyl isomerase H (cyclophilin H) 5.2.1.8 ko03040 Spliceosome U-snRNP-associated cyclophilin type peptidyl-prolyl cis-trans isomerase O Posttranslational modification, protein turnover, chaperones ; IPR002130 [Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain] -- -- Q9ERR7 Selenoprotein F Selenof 1223.8 1293.6 1313.9 1381.5 1383.3 1370.6 0.926464187261208 0.0625991561102008 -0.11019288534744 Nonsignificant None -- -- -- -- -- Selenoprotein R General function prediction only ; IPR014912 [Sep15/SelM redox] -- -- Q7TMH5 Mrpl13 protein (Fragment) Mrpl13 963 866.5 753.9 750 771.5 825.9 1.10053676407941 0.289629159916682 0.138207340112821 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L13 -- ko03010 Ribosome Mitochondrial/chloroplast ribosomal protein L13 J Translation, ribosomal structure and biogenesis ; IPR005822 [Ribosomal protein L13] -- -- Q3UNQ4 Platelet-activating factor acetylhydrolase Pafah2 909.5 888 914.1 934.8 945.6 982.1 0.94728384279476 0.0375095136247947 -0.0781313173083028 Nonsignificant None 2 Molecular Function:1-alkyl-2-acetylglycerophosphocholine esterase activity (GO:0003847),Biological Process:lipid catabolic process (GO:0016042) platelet-activating factor acetylhydrolase 3.1.1.47 ko00565 Ether lipid metabolism ko01100 Metabolic pathways Phospholipase A2 (platelet-activating factor acetylhydrolase in humans) I Lipid transport and metabolism ; IPR005065 [Platelet-activating factor acetylhydrolase-like] -- -- A0A087WPT7 Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase (Fragment) Inppl1 397.8 374.5 334.4 364.5 330.3 342.3 1.06711021116575 0.33228573224669 0.0937091854324201 Nonsignificant None -- -- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 3.1.3.86 ko00562 Inositol phosphate metabolism ko04070 Phosphatidylinositol signaling system ko04662 B cell receptor signaling pathway ko04666 Fc gamma R-mediated phagocytosis ko04910 Insulin signaling pathway Inositol polyphosphate 5-phosphatase and related proteins U Intracellular trafficking, secretion, and vesicular transport ; IPR000980 [SH2 domain] ; IPR005135[Endonuclease/exonuclease/phosphatase] -- -- I6L970 Aup1 protein Aup1 1424 1464.8 1498 1392.7 1470.4 1374.2 1.03528190121068 0.243051121920805 0.0500236586453389 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) ancient ubiquitous protein 1 -- -- Predicted phosphate acyltransferase, contains PlsC domain I Lipid transport and metabolism ; IPR003892 [Ubiquitin system component Cue] -- -- Q8CGE8 Interferon-activable protein 205-A Ifi205a 74.3 80 60.7 40.1 41.4 72 1.40065146579805 0.159831624017663 0.486098004219281 Nonsignificant None -- -- -- -- -- -- -- -- IPR004020 [DAPIN domain] ; IPR004021[HIN-200/IF120x] -- -- A0A571BEG7 InaD-like protein Patj 136.4 125.8 142.6 142.1 157.5 152.1 0.896170024352446 0.0788645685414061 -0.158155623743206 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) InaD-like protein -- ko04390 Hippo signaling pathway ko04530 Tight junction ko05165 Human papillomavirus infection FOG: PDZ domain S Function unknown ; IPR001478 [PDZ domain] ; IPR015132[L27-2] -- -- Q6ZPY7 Lysine-specific demethylase 3B Kdm3b 697.8 694.1 596.8 564 571.3 555.9 1.17591059602649 0.0929744386395878 0.233778376864462 Nonsignificant None -- -- lysine-specific demethylase 3 1.14.11.- -- Putative transcription factor 5qNCA, contains JmjC domain K Transcription ; IPR003347 [JmjC domain] -- -- Q80VQ1 Leucine-rich repeat-containing protein 1 Lrrc1 158.8 155.5 186 194.6 200.4 194.6 0.848541383989145 0.0391481196763111 -0.236943072102367 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- FOG: Leucine rich repeat R General function prediction only ; IPR001611 [Leucine-rich repeat] -- -- Q9CT10 Ran-binding protein 3 Ranbp3 561.4 608.1 577.8 602 593 593.3 0.977073198009282 0.384045483018155 -0.0334614483034634 Nonsignificant None 1 Biological Process:intracellular transport (GO:0046907) Ran-binding protein 3 -- ko05166 HTLV-I infection Ran-binding protein RANBP3 U Intracellular trafficking, secretion, and vesicular transport ; IPR000156 [Ran binding domain] -- -- Q3U0J1 Peptidyl-prolyl cis-trans isomerase Ppil1 2307.6 2397.4 2524.2 2060.1 2275.6 2185.4 1.10858597475886 0.0561731024168425 0.148720660641336 Nonsignificant None 3 Biological Process:protein peptidyl-prolyl isomerization (GO:0000413),Molecular Function:peptidyl-prolyl cis-trans isomerase activity (GO:0003755),Biological Process:protein folding (GO:0006457) peptidyl-prolyl cis-trans isomerase-like 1 5.2.1.8 ko03040 Spliceosome Cyclophilin type peptidyl-prolyl cis-trans isomerase O Posttranslational modification, protein turnover, chaperones ; IPR002130 [Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain] -- -- P52795 Ephrin-B1 Efnb1 1123.9 1041.3 1352.1 1469.1 1516.7 1464 0.79044001977617 0.0301845231043621 -0.339272102834452 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) ephrin-B -- ko04360 Axon guidance Ephrin, ligand for Eph receptor tyrosine kinase T Signal transduction mechanisms ; IPR001799 [Ephrin receptor-binding domain] -- -- Q64378 Peptidyl-prolyl cis-trans isomerase FKBP5 Fkbp5 765.5 773.4 819.9 785.6 777.8 751.7 1.01887607446763 0.50325621989913 0.0269785876926967 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) FK506-binding protein 4/5 5.2.1.8 ko04915 Estrogen signaling pathway FKBP-type peptidyl-prolyl cis-trans isomerase O Posttranslational modification, protein turnover, chaperones ; IPR001179 [FKBP-type peptidyl-prolyl cis-trans isomerase domain] ; IPR001440[Tetratricopeptide repeat 1] ; IPR019734[Tetratricopeptide repeat] -- -- Q923G2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 Polr2h 800.9 780 756.1 860.9 873.5 940.6 0.873644859813084 0.0156583559718341 -0.194881157393046 Nonsignificant None -- -- DNA-directed RNA polymerases I, II, and III subunit RPABC3 -- ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways ko03020 RNA polymerase ko04623 Cytosolic DNA-sensing pathway ko05016 Huntington's disease ko05169 Epstein-Barr virus infection RNA polymerase subunit 8 K Transcription ; IPR005570 [RNA polymerase, Rpb8] -- -- Q545U2 Mitochondrial import inner membrane translocase subunit TIM17 Timm17a 239.6 241.5 226.9 216.1 226.9 238.7 1.03858002053689 0.333346389055158 0.0546123772651002 Nonsignificant None -- -- mitochondrial import inner membrane translocase subunit TIM17 -- -- Mitochondrial import inner membrane translocase, subunit TIM17 U Intracellular trafficking, secretion, and vesicular transport ; IPR003397 [Mitochondrial inner membrane translocase subunit Tim17/Tim22/Tim23/peroxisomal protein PMP24] -- -- Q6ZQH8 Nucleoporin NUP188 Nup188 286.4 300.7 223.4 217.6 225.2 230.8 1.20323634204276 0.130636960069945 0.266920047338508 Nonsignificant None -- -- nuclear pore complex protein Nup188 -- ko03013 RNA transport Uncharacterized conserved protein S Function unknown ; IPR018864 [Nucleoporin Nup188] -- -- Q2TPA8 Hydroxysteroid dehydrogenase-like protein 2 Hsdl2 810.3 759.5 715.7 764 693.1 774.6 1.02410718286508 0.656943497984786 0.0343667154314186 Nonsignificant None -- -- -- -- -- Reductases with broad range of substrate specificities R General function prediction only ; IPR002347 [Short-chain dehydrogenase/reductase SDR] ; IPR003033[SCP2 sterol-binding domain] -- -- Q6DIC0 Probable global transcription activator SNF2L2 Smarca2 69.9 60.7 62.6 62.3 77.5 74.6 0.901119402985075 0.263602835246369 -0.150209811621999 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Molecular Function:histone binding (GO:0042393) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2/4 3.6.4.- ko05225 Hepatocellular carcinoma Chromatin remodeling complex SWI/SNF, component SWI2 and related ATPases (DNA/RNA helicase superfamily) BK Chromatin structure and dynamics ; Transcription ; IPR000330 [SNF2-related, N-terminal domain] ; IPR001487[Bromodomain] ; IPR001650[Helicase, C-terminal] ; IPR006576[BRK domain] ; IPR014012[Helicase/SANT-associated domain] ; IPR029295[Snf2, ATP coupling domain] -- -- B9EKQ1 Tbc1d8b protein Tbc1d8b 468.3 406.4 545.4 543.2 548.5 522.1 0.879972735159251 0.190476395649637 -0.184469270523681 Nonsignificant None -- -- TBC1 domain family member 8/9 -- -- GTPase-activating protein VRP R General function prediction only ; IPR000195 [Rab-GTPase-TBC domain] ; IPR004182[GRAM domain] -- -- P61957 Small ubiquitin-related modifier 2 Sumo2 2637.6 2994.2 1777.1 1880.6 1842.8 1932.2 1.31001131621755 0.246691827069984 0.389579274190537 Nonsignificant None -- -- small ubiquitin-related modifier -- ko03013 RNA transport ko05418 Fluid shear stress and atherosclerosis Ubiquitin-like proteins O Posttranslational modification, protein turnover, chaperones ; IPR022617 [Rad60/SUMO-like domain] -- -- Q8K2D3 Enhancer of mRNA-decapping protein 3 Edc3 417 395.3 369.8 396.9 384 407.7 0.994531381457177 0.893983701029446 -0.00791120029053438 Nonsignificant None -- -- enhancer of mRNA-decapping protein 3 -- ko03018 RNA degradation Uncharacterized conserved protein S Function unknown ; IPR004443 [YjeF N-terminal domain] ; IPR019050[FDF domain] ; IPR025609[Lsm14-like, N-terminal] -- -- P70303 CTP synthase 2 Ctps2 413.8 437.3 472.6 530.2 520.7 546.1 0.828866624921728 0.00809454319936163 -0.270788122291229 Nonsignificant None 2 Molecular Function:CTP synthase activity (GO:0003883),Biological Process:pyrimidine nucleotide biosynthetic process (GO:0006221) CTP synthase 6.3.4.2 ko00240 Pyrimidine metabolism ko01100 Metabolic pathways CTP synthase (UTP-ammonia lyase) F Nucleotide transport and metabolism ; IPR017456 [CTP synthase, N-terminal] ; IPR017926[Glutamine amidotransferase] -- -- Q9D8G5 Regenerating islet-derived protein 4 Reg4 1560.5 1388.9 1031.4 2447.8 2588.2 2846.4 0.505023850603877 0.00261221798524918 -0.985576571705291 Significant down -- -- regenerating islet-derived protein 4 -- ko05226 Gastric cancer C-type lectin TV Signal transduction mechanisms ; Defense mechanisms ; IPR001304 [C-type lectin-like] -- -- A0A0R4J1Y3 tRNA N6-adenosine threonylcarbamoyltransferase Osgep 950.4 993.3 1087.5 1070.1 1100.5 1056.6 0.939266236985622 0.199221707997088 -0.0903939441042531 Nonsignificant None -- -- N6-L-threonylcarbamoyladenine synthase 2.3.1.234 -- Predicted metalloprotease with chaperone activity (RNAse H/HSP70 fold) O Posttranslational modification, protein turnover, chaperones ; IPR000905 [Gcp-like domain] -- -- Q922E4 Ethanolamine-phosphate cytidylyltransferase Pcyt2 928.7 876.2 939.1 1022.1 1138.4 994.6 0.869703020506482 0.046665111391353 -0.201405250232051 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:biosynthetic process (GO:0009058) ethanolamine-phosphate cytidylyltransferase 2.7.7.14 ko00440 Phosphonate and phosphinate metabolism ko00564 Glycerophospholipid metabolism ko01100 Metabolic pathways Choline phosphate cytidylyltransferase/Predicted CDP-ethanolamine synthase I Lipid transport and metabolism ; IPR004821 [Cytidyltransferase-like domain] -- -- O70591 Prefoldin subunit 2 Pfdn2 1360.2 1276 1266.3 1234.2 1251 1261.2 1.04166666666667 0.166803788033079 0.0588936890535686 Nonsignificant None 3 Biological Process:protein folding (GO:0006457),Cellular Component:prefoldin complex (GO:0016272),Molecular Function:unfolded protein binding (GO:0051082) prefoldin subunit 2 -- -- Molecular chaperone Prefoldin, subunit 2 O Posttranslational modification, protein turnover, chaperones ; IPR002777 [Prefoldin beta-like] -- -- Q9DCS2 Methyltransferase-like 26 Mettl26 687 660.9 792.7 873.7 814 908.4 0.824544509071299 0.0358739649223475 -0.278330722166656 Nonsignificant None -- -- -- -- -- -- -- -- IPR010342 [Protein of unknown function DUF938] -- -- E9PYN9 Amine oxidase Aoc1 768.9 692.5 673.4 821.2 848.6 868.8 0.840935948948239 0.0140220178537172 -0.249932175089191 Nonsignificant None 5 Molecular Function:copper ion binding (GO:0005507),Molecular Function:primary amine oxidase activity (GO:0008131),Biological Process:amine metabolic process (GO:0009308),Molecular Function:quinone binding (GO:0048038),Biological Process:oxidation-reduction process (GO:0055114) diamine oxidase 1.4.3.22 ko00330 Arginine and proline metabolism ko00340 Histidine metabolism ko00380 Tryptophan metabolism ko01100 Metabolic pathways Copper amine oxidase Q Secondary metabolites biosynthesis, transport and catabolism ; IPR015798 [Copper amine oxidase, C-terminal] ; IPR015800[Copper amine oxidase, N2-terminal] ; IPR015802[Copper amine oxidase, N3-terminal] -- -- Q9WVC8 Chloride anion exchanger Slc26a3 1078.9 929.4 918 2090.8 2018.5 1543.5 0.517672657797905 0.00713835779765762 -0.949887974295405 Significant down 3 Biological Process:sulfate transport (GO:0008272),Molecular Function:sulfate transmembrane transporter activity (GO:0015116),Cellular Component:integral component of membrane (GO:0016021) solute carrier family 26 (chloride anion exchanger), member 3 -- ko04972 Pancreatic secretion ko04978 Mineral absorption Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) P Inorganic ion transport and metabolism ; IPR002645 [STAS domain] ; IPR011547[SLC26A/SulP transporter domain] -- -- Q3U5R2 Uncharacterized protein Pigt 1241.6 1221 1147.4 1170.3 1225.1 1230.6 0.995587424158853 0.884524407146589 -0.00638008796962453 Nonsignificant None 2 Biological Process:attachment of GPI anchor to protein (GO:0016255),Cellular Component:GPI-anchor transamidase complex (GO:0042765) phosphatidylinositol glycan, class T -- ko00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis ko01100 Metabolic pathways GPI transamidase complex, GPI16/PIG-T component, involved in glycosylphosphatidylinositol anchor biosynthesis MO Cell wall/membrane/envelope biogenesis ; Posttranslational modification, protein turnover, chaperones ; IPR007245 [GPI transamidase component PIG-T] -- -- B1AQ75 Keratin, type I cuticular Ha6 Krt36 251.9 228.5 209.1 205.6 248.2 220.8 1.02208716276312 0.7913684481066 0.0315182333832163 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) type I keratin, acidic -- -- -- -- -- IPR001664 [Intermediate filament protein] -- -- P0DOV1 Interferon-activable protein 205-B Mnda 142.4 177.9 158.8 146.9 146.8 129.1 1.13315988647114 0.188197437656091 0.180351436749706 Nonsignificant None -- -- -- -- -- -- -- -- IPR004020 [DAPIN domain] ; IPR004021[HIN-200/IF120x] -- -- A2A432 Cullin-4B Cul4b 159.1 154.5 145.3 181.1 173.5 167.2 0.879455730164814 0.0213565822013859 -0.18531713740518 Nonsignificant None 2 Biological Process:ubiquitin-dependent protein catabolic process (GO:0006511),Molecular Function:ubiquitin protein ligase binding (GO:0031625) cullin 4 -- ko03420 Nucleotide excision repair ko04120 Ubiquitin mediated proteolysis Cullins D Cell cycle control, cell division, chromosome partitioning ; IPR001373 [Cullin, N-terminal] ; IPR019559[Cullin protein, neddylation domain] -- -- A0A0R4J078 UBX domain-containing protein 4 Ubxn4 1195.2 1125.1 1109.7 971.8 975.4 1068.8 1.13726790450928 0.0286589492871837 0.18557214779151 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Ubiquitin regulatory protein UBXD2, contains UAS and UBX domains R General function prediction only ; IPR001012 [UBX domain] -- -- Q91XT3 Stathmin Stmn1 2258.3 2301.8 2055.7 1725.9 1837.8 1673.3 1.2632805041054 0.00695474071034145 0.337175016757973 Nonsignificant None 1 Biological Process:regulation of microtubule polymerization or depolymerization (GO:0031110) stathmin -- ko04010 MAPK signaling pathway ko05206 MicroRNAs in cancer -- -- -- IPR000956 [Stathmin family] -- -- Q99M87 DnaJ homolog subfamily A member 3, mitochondrial Dnaja3 861.8 888.4 993.8 951.3 942.8 888.9 0.98598634567014 0.786059098950147 -0.0203604271587951 Nonsignificant None 2 Molecular Function:heat shock protein binding (GO:0031072),Molecular Function:unfolded protein binding (GO:0051082) DnaJ homolog subfamily A member 3 -- ko05203 Viral carcinogenesis Molecular chaperone (DnaJ superfamily) O Posttranslational modification, protein turnover, chaperones ; IPR001305 [Heat shock protein DnaJ, cysteine-rich domain] ; IPR001623[DnaJ domain] ; IPR002939[Chaperone DnaJ, C-terminal] -- -- Q9D1C8 Vacuolar protein sorting-associated protein 28 homolog Vps28 919.5 852.1 926.7 873.7 939.5 945.1 0.978247471268535 0.577339886236522 -0.031728619066746 Nonsignificant None -- -- ESCRT-I complex subunit VPS28 -- ko04144 Endocytosis Vacuolar sorting protein VPS28 U Intracellular trafficking, secretion, and vesicular transport ; IPR007143 [Vacuolar protein sorting-associated, VPS28] -- -- Q8BGW1 Alpha-ketoglutarate-dependent dioxygenase FTO Fto 717 700.1 764.1 775 748.5 786.6 0.944201549716463 0.125303004416696 -0.0828332440504968 Nonsignificant None -- -- mRNA N6-methyladenine demethylase 1.14.11.53 -- -- -- -- IPR024366 [Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal] ; IPR024367[Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain] -- -- Q9D903 Probable rRNA-processing protein EBP2 Ebna1bp2 1917.8 2054.2 1549.9 1080.9 1118.7 1129.7 1.65857687802241 0.0388023126467352 0.729945885186632 Significant up -- -- rRNA-processing protein EBP2 -- -- Nucleolar protein-like/EBNA1-binding protein A RNA processing and modification ; IPR008610 [Eukaryotic rRNA processing] -- -- Q60GT3 Polypeptide N-acetylgalactosaminyltransferase Galnt12 594.1 557.7 711.1 753.9 679.5 703.6 0.871736078614881 0.148919789782355 -0.198036675143936 Nonsignificant None -- -- polypeptide N-acetylgalactosaminyltransferase 2.4.1.41 ko00512 Mucin type O-glycan biosynthesis ko01100 Metabolic pathways Polypeptide N-acetylgalactosaminyltransferase O Posttranslational modification, protein turnover, chaperones ; IPR000772 [Ricin B, lectin domain] ; IPR001173[Glycosyltransferase 2-like] -- -- Q6A009 E3 ubiquitin-protein ligase listerin Ltn1 567 580.3 590.2 529.2 527.5 525.9 1.0978769114116 0.0150679935458367 0.13471631549943 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:zinc ion binding (GO:0008270) Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR001841 [Zinc finger, RING-type] -- -- E9Q2H1 E3 ubiquitin-protein ligase UBR5 Ubr5 630 602.7 636.9 549.9 624.7 587.2 1.06118742195482 0.208454403059154 0.0856794808008555 Nonsignificant None 3 Molecular Function:RNA binding (GO:0003723),Molecular Function:ubiquitin-protein transferase activity (GO:0004842),Molecular Function:ubiquitin binding (GO:0043130) E3 ubiquitin-protein ligase EDD1 2.3.2.26 ko04120 Ubiquitin mediated proteolysis Predicted ubiquitin-protein ligase/hyperplastic discs protein, HECT superfamily O Posttranslational modification, protein turnover, chaperones ; IPR000569 [HECT domain] ; IPR002004[Polyadenylate-binding protein/Hyperplastic disc protein] ; IPR024725[E3 ubiquitin ligase EDD, ubiquitin-associated domain] -- -- Q9CPU4 Microsomal glutathione S-transferase 3 Mgst3 692.7 573.4 514.3 787.9 823.8 858.6 0.720722179492369 0.015038886799547 -0.472484851385059 Nonsignificant None -- -- glutathione S-transferase 2.5.1.18 ko00480 Glutathione metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko01524 Platinum drug resistance ko05200 Pathways in cancer ko05204 Chemical carcinogenesis ko05225 Hepatocellular carcinoma ko05418 Fluid shear stress and atherosclerosis -- -- -- IPR001129 [Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein] -- -- P04441 H-2 class II histocompatibility antigen gamma chain Cd74 1233.5 1261.2 1191.1 1313.6 1267.2 1209.5 0.972429622984988 0.392318782101511 -0.0403342522379283 Nonsignificant None 5 Biological Process:intracellular protein transport (GO:0006886),Biological Process:immune response (GO:0006955),Cellular Component:membrane (GO:0016020),Biological Process:antigen processing and presentation (GO:0019882),Molecular Function:MHC class II protein binding (GO:0042289) CD74 antigen -- ko04612 Antigen processing and presentation ko05152 Tuberculosis ko05168 Herpes simplex infection -- -- -- IPR000716 [Thyroglobulin type-1] ; IPR011988[MHC class II-associated invariant chain, trimerisation] ; IPR015386[MHC class II-associated invariant chain/CLIP, MHC II-interacting] -- -- E9QMK9 D-glutamate cyclase, mitochondrial Dglucy 441 435.1 613.5 696.1 658.2 568.1 0.774864752392842 0.107410414084613 -0.367983575571073 Nonsignificant None -- -- D-glutamate cyclase 4.2.1.48 ko00471 D-Glutamine and D-glutamate metabolism -- -- -- IPR009906 [Protein of unknown function DUF1445] ; IPR025504[Domain of unknown function DUF4392] -- -- Q3U011 GLTP domain-containing protein Gltp 766.8 738.2 776.2 796.4 808.1 778.7 0.957200402819738 0.0757587325361212 -0.0631070908798218 Nonsignificant None 4 Cellular Component:cytoplasm (GO:0005737),Molecular Function:glycolipid transporter activity (GO:0017089),Biological Process:glycolipid transport (GO:0046836),Molecular Function:glycolipid binding (GO:0051861) -- -- -- Glycolipid transfer protein G Carbohydrate transport and metabolism ; IPR014830 [Glycolipid transfer protein domain] -- -- Q9CQT1 Methylthioribose-1-phosphate isomerase Mri1 772.1 838.2 824.8 899.8 919.8 1037.7 0.85223812690302 0.0414843966362463 -0.230671499527657 Nonsignificant None 1 Biological Process:cellular metabolic process (GO:0044237) methylthioribose-1-phosphate isomerase 5.3.1.23 ko00270 Cysteine and methionine metabolism ko01100 Metabolic pathways Predicted translation initiation factor related to eIF-2B alpha/beta/delta subunits (CIG2/IDI2) J Translation, ribosomal structure and biogenesis ; IPR000649 [Initiation factor 2B-related] -- -- E9QP00 Transformer-2 protein homolog alpha Tra2a 1179.5 1220.1 1200.9 1142 1145.8 1165.6 1.04259570278566 0.0238473411919493 0.0601798187751329 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) transformer-2 protein -- ko03040 Spliceosome FOG: RRM domain R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- D3Z3N4 Heterogeneous nuclear ribonucleoprotein H3 Hnrnph3 1032.7 1069.1 1364.4 1341 1359.6 1290.9 0.868395340097708 0.177124364718509 -0.203576110569457 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) heterogeneous nuclear ribonucleoprotein F/H -- -- Splicing factor hnRNP-F and related RNA-binding proteins A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- Q8CGB6 Tensin-2 Tns2 589.2 570.5 630 769.7 726.8 695.5 0.81646897810219 0.00846687644137235 -0.292530023538064 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) tensin -- -- Clathrin coat dissociation kinase GAK/PTEN/Auxilin and related tyrosine phosphatases TR Signal transduction mechanisms ; General function prediction only ; IPR000980 [SH2 domain] ; IPR013625[Tensin/EPS8 phosphotyrosine-binding domain] ; IPR014020[Tensin phosphatase, C2 domain] -- -- Q921K8 TRPM8 channel-associated factor 2 Tcaf2 755.8 684.8 664.9 701.8 700.3 760.4 0.97364161849711 0.60558574544024 -0.0385372572423553 Nonsignificant None -- -- -- -- -- -- -- -- IPR031161 [Peptidase family M60 domain] -- -- A0A2I3BQZ9 Amyloid-beta A4 protein App 1232.8 1238.2 1440.5 1445.9 1437.1 1475.8 0.897380012847573 0.0979763855427008 -0.156209043352275 Nonsignificant None 4 Molecular Function:serine-type endopeptidase inhibitor activity (GO:0004867),Molecular Function:heparin binding (GO:0008201),Cellular Component:integral component of membrane (GO:0016021),Molecular Function:transition metal ion binding (GO:0046914) amyloid beta A4 protein -- ko04726 Serotonergic synapse ko05010 Alzheimer's disease Beta amyloid precursor protein R General function prediction only ; IPR002223 [Pancreatic trypsin inhibitor Kunitz domain] ; IPR011178[Amyloidogenic glycoprotein, copper-binding] ; IPR013803[Amyloidogenic glycoprotein, amyloid-beta peptide] ; IPR015849[Amyloidogenic glycoprotein, heparin-binding] ; IPR019543[Beta-amyloid precursor protein C-terminal] ; IPR024329[Amyloidogenic glycoprotein, E2 domain] -- -- B2RUA5 SAPS domain family, member 1 Ppp6r1 687.2 690.3 786.3 803.5 726.1 704.9 0.968359812038487 0.622360462743135 -0.046384887685845 Nonsignificant None -- -- serine/threonine-protein phosphatase 6 regulatory subunit 1 -- -- SAP family cell cycle dependent phosphatase-associated protein D Cell cycle control, cell division, chromosome partitioning ; IPR007587 [SIT4 phosphatase-associated protein family] -- -- Q9D0Q7 39S ribosomal protein L45, mitochondrial Mrpl45 1570 1520.3 1681.5 1596.7 1578.9 1595.4 1.00016767973171 0.996059381060714 0.000241890437903741 Nonsignificant None -- -- large subunit ribosomal protein L45 -- -- Putative mitochondrial/chloroplast ribosomal protein L45 J Translation, ribosomal structure and biogenesis ; IPR007379 [Tim44-like domain] -- -- O88508 DNA (cytosine-5)-methyltransferase 3A Dnmt3a 490 485.6 533.8 417 408.5 409.9 1.22179051319411 0.00425592374079476 0.288996943516594 Nonsignificant None -- -- DNA (cytosine-5)-methyltransferase 3A 2.1.1.37 ko00270 Cysteine and methionine metabolism ko01100 Metabolic pathways ko05206 MicroRNAs in cancer -- -- -- IPR000313 [PWWP domain] ; IPR029063[S-adenosyl-L-methionine-dependent methyltransferase] -- -- E9Q467 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 Abcc4 390.2 372.8 284.6 352.1 348.5 375.1 0.973877475132472 0.795027693520538 -0.03818781861454 Nonsignificant None 5 Molecular Function:ATP binding (GO:0005524),Biological Process:transport (GO:0006810),Cellular Component:integral component of membrane (GO:0016021),Molecular Function:ATPase activity (GO:0016887),Biological Process:transmembrane transport (GO:0055085) ATP-binding cassette, subfamily C (CFTR/MRP), member 4 -- ko01523 Antifolate resistance ko02010 ABC transporters ko04024 cAMP signaling pathway ko04976 Bile secretion Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Q Secondary metabolites biosynthesis, transport and catabolism ; IPR003439 [ABC transporter-like] ; IPR011527[ABC transporter type 1, transmembrane domain] -- -- P46737 Lys-63-specific deubiquitinase BRCC36 Brcc3 497 510.6 493.5 509.4 476.6 485.8 1.01990759614078 0.427584237595123 0.0284384496200472 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) BRCA1/BRCA2-containing complex subunit 3 3.4.19.- ko03440 Homologous recombination ko04621 NOD-like receptor signaling pathway 26S proteasome regulatory complex, subunit RPN11 O Posttranslational modification, protein turnover, chaperones ; IPR000555 [JAB1/MPN/MOV34 metalloenzyme domain] -- -- Q5SUF2 Luc7-like protein 3 Luc7l3 1631.6 1674.4 1370.2 1193.1 1230.1 1232.1 1.27929308127924 0.0675253061701478 0.355346818144805 Nonsignificant None 3 Molecular Function:mRNA binding (GO:0003729),Cellular Component:U1 snRNP (GO:0005685),Biological Process:mRNA splice site selection (GO:0006376) -- -- -- Spliceosome subunit A RNA processing and modification ; IPR004882 [Luc7-related] -- -- P97355 Spermine synthase Sms 386 354.8 443.5 479.5 428.4 493.3 0.845204110762204 0.091018736987975 -0.24262831085892 Nonsignificant None -- -- spermine synthase 2.5.1.22 ko00270 Cysteine and methionine metabolism ko00330 Arginine and proline metabolism ko00410 beta-Alanine metabolism ko00480 Glutathione metabolism ko01100 Metabolic pathways Spermidine synthase E Amino acid transport and metabolism ; -- -- -- Q9DCV4 Regulator of microtubule dynamics protein 1 Rmdn1 878.8 904.6 1009.2 1097.6 1061.3 1078.3 0.862659088100828 0.0228605822647949 -0.213137557587852 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- D3YUV1 Nuclear receptor-binding protein Nrbp1 344.5 296.9 291 280.7 302.3 292.3 1.06523477664801 0.351125834042153 0.09117143399784 Nonsignificant None 2 Molecular Function:protein kinase activity (GO:0004672),Biological Process:protein phosphorylation (GO:0006468) nuclear receptor-binding protein -- -- Protein kinase T Signal transduction mechanisms ; IPR001245 [Serine-threonine/tyrosine-protein kinase catalytic domain] -- -- Q80UP5 Ankyrin repeat domain-containing protein 13A Ankrd13a 434.3 397.6 438.8 402.6 414.9 425.1 1.02261387413488 0.55555231008983 0.0322615047829099 Nonsignificant None -- -- ankyrin repeat domain-containing protein 13 -- -- Ankyrin repeat protein R General function prediction only ; IPR021832 [Ankyrin repeat domain-containing protein 13] -- -- A0A0N4SV80 Zinc finger protein 638 Zfp638 485.2 545.4 521.2 503.1 501.2 509.6 1.02503467864456 0.546257514570422 0.0356727193523906 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- P97352 Protein S100-A13 S100a13 1729.4 1723.7 1871.1 1917.8 1736.6 1960.2 0.948277704555979 0.312446733740477 -0.0766184784689288 Nonsignificant None -- -- -- -- -- -- -- -- IPR013787 [S100/CaBP-9k-type, calcium binding, subdomain] -- -- P52624 Uridine phosphorylase 1 Upp1 993.6 1049.5 1033.6 1256.8 1590.7 1092.4 0.780908144876774 0.187238575156644 -0.356775235027523 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:nucleoside metabolic process (GO:0009116) uridine phosphorylase 2.4.2.3 ko00240 Pyrimidine metabolism ko00983 Drug metabolism - other enzymes ko01100 Metabolic pathways Uridine phosphorylase F Nucleotide transport and metabolism ; IPR000845 [Nucleoside phosphorylase domain] -- -- Q8BH60 Golgi-associated PDZ and coiled-coil motif-containing protein Gopc 1417.4 1492 1519.7 1548.4 1572.3 1542.6 0.94977805416765 0.0704914534229901 -0.0743376736134987 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- FOG: PDZ domain S Function unknown ; IPR001478 [PDZ domain] -- -- A0A286YDB7 Translocon-associated protein subunit alpha (Fragment) Ssr1 1069.8 1005.3 1150.1 1080.1 1072.4 987.9 1.02700292956311 0.610612932197686 0.038440297001918 Nonsignificant None 1 Cellular Component:endoplasmic reticulum membrane (GO:0005789) translocon-associated protein subunit alpha -- ko04141 Protein processing in endoplasmic reticulum Translocon-associated complex TRAP, alpha subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR005595 [Translocon-associated protein (TRAP), alpha subunit] -- -- Q8K019 Bcl-2-associated transcription factor 1 Bclaf1 2407.1 2430.3 2629.1 2267.5 2275.2 2375.3 1.07928592078635 0.0804463468133689 0.110077109364525 Nonsignificant None -- -- bcl2 associated transcription factor 1 -- -- -- -- -- IPR029199 [THRAP3/BCLAF1 family] -- -- Q8VDG5 Phosphopantothenate--cysteine ligase Ppcs 581.3 562.2 692.7 696.7 639.2 694.6 0.904309283427727 0.222096376534205 -0.145111820747072 Nonsignificant None -- -- phosphopantothenate---cysteine ligase (ATP) 6.3.2.51 ko00770 Pantothenate and CoA biosynthesis ko01100 Metabolic pathways Uncharacterized conserved protein with similarity to phosphopantothenoylcysteine synthetase/decarboxylase R General function prediction only ; IPR007085 [DNA/pantothenate metabolism flavoprotein, C-terminal] -- -- E9Q9X1 Dystonin Dst 416.5 443.7 466.3 518.2 473.1 462.2 0.912624699002408 0.131574101632192 -0.131906395907541 Nonsignificant None 4 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:protein binding (GO:0005515),Cellular Component:cytoskeleton (GO:0005856),Molecular Function:microtubule binding (GO:0008017) dystonin -- -- Dystonin, GAS (Growth-arrest-specific protein), and related proteins Z Cytoskeleton ; IPR001101 [Plectin repeat] ; IPR001715[Calponin homology domain] ; IPR002017[Spectrin repeat] ; IPR002048[EF-hand domain] ; IPR003108[Gas2-related domain] -- -- Q9D1I5 Methylmalonyl-CoA epimerase, mitochondrial Mcee 394.1 524 652 855.6 774.1 617.8 0.698598442714127 0.0913184671803535 -0.517464668145295 Nonsignificant None -- -- methylmalonyl-CoA/ethylmalonyl-CoA epimerase 5.1.99.1 ko00280 Valine, leucine and isoleucine degradation ko00630 Glyoxylate and dicarboxylate metabolism ko00640 Propanoate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism Glyoxalase G Carbohydrate transport and metabolism ; -- -- -- P58022 Lysyl oxidase homolog 2 Loxl2 701.8 740.9 630 594.5 559.4 548.9 1.21723044397463 0.0250119882622681 0.28360232245345 Nonsignificant None 4 Molecular Function:scavenger receptor activity (GO:0005044),Molecular Function:copper ion binding (GO:0005507),Cellular Component:membrane (GO:0016020),Biological Process:oxidation-reduction process (GO:0055114) lysyl oxidase-like protein 2/3/4 1.4.3.- -- -- -- -- IPR001190 [SRCR domain] ; IPR001695[Lysyl oxidase] -- -- Q8VIM9 Immunity-related GTPase family Q protein Irgq 726.1 711.4 733.3 799.9 798 739.6 0.92868449197861 0.0558226709472645 -0.106739551207326 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q4VAA2 Protein CDV3 Cdv3 1691.1 1767.1 1761.4 1352.4 1436.7 1341.2 1.26373386921047 0.000726382155650066 0.337692677126441 Nonsignificant None -- -- -- -- -- -- -- -- IPR026806 [Protein CDV3] -- -- Q3UXG7 GDP-fucose protein O-fucosyltransferase 1 Pofut1 810.7 812.9 879.8 676.1 685.6 761.3 1.17918040508714 0.0227649188735417 0.237784455903753 Nonsignificant None -- -- peptide-O-fucosyltransferase 2.4.1.221 ko00514 Other types of O-glycan biosynthesis GDP-fucose protein O-fucosyltransferase O Posttranslational modification, protein turnover, chaperones ; IPR019378 [GDP-fucose protein O-fucosyltransferase] -- -- Q9JJY3 Sphingomyelin phosphodiesterase 3 Smpd3 667.1 642.9 680.3 691.6 738.6 754.5 0.911017531011123 0.0412027079901831 -0.134449278335935 Nonsignificant None -- -- sphingomyelin phosphodiesterase 3 3.1.4.12 ko00600 Sphingolipid metabolism ko01100 Metabolic pathways -- -- -- IPR005135 [Endonuclease/exonuclease/phosphatase] -- -- A0A140LJJ5 A-kinase anchor protein 13 Akap13 1389.6 1399.2 1181.2 1072.4 1061.7 1086.3 1.23276611601043 0.0709272058876864 0.30189911338363 Nonsignificant None 2 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Biological Process:regulation of Rho protein signal transduction (GO:0035023) A-kinase anchor protein 13 -- -- Predicted guanine nucleotide exchange factor T Signal transduction mechanisms ; IPR000219 [Dbl homology (DH) domain] -- -- Q8VH34 LAMP-1 Lamp1 1651 1673.6 1663.9 1607.3 1680.9 1712.8 0.99750049990002 0.902434748951897 -0.00361053054175329 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) lysosomal-associated membrane protein 1/2 -- ko04140 Autophagy - animal ko04142 Lysosome ko04145 Phagosome ko05152 Tuberculosis Lysosomal-associated membrane protein R General function prediction only ; IPR002000 [Lysosome-associated membrane glycoprotein] -- -- Q8BHS3 Pre-mRNA-splicing factor RBM22 Rbm22 837.4 837.5 800.6 749.2 750 732.8 1.10909498207885 0.0038551146122494 0.149382922132973 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) pre-mRNA-splicing factor RBM22/SLT11 -- ko03040 Spliceosome Predicted RNA-binding protein (RRM superfamily) R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- A2AK37 Expressed sequence AA467197 (Fragment) AA467197 117.1 102.7 112.4 188.3 205.2 174.8 0.584550413513989 0.00128596623347148 -0.774600642088953 Significant down -- -- -- -- -- -- -- -- IPR010530 [NADH-ubiquinone reductase complex 1 MLRQ subunit] -- -- Q3UMB9 WASH complex subunit 4 Washc4 256.1 273.1 283.8 319.1 310.6 271.8 0.901830282861897 0.150994162068355 -0.149072139357314 Nonsignificant None -- -- WASH complex subunit 7 -- ko04144 Endocytosis Uncharacterized conserved protein S Function unknown ; IPR028191 [WASH complex subunit 7, N-terminal] ; IPR028282[WASH complex subunit 7, central domain] ; IPR028283[WASH complex subunit 7, C-terminal] -- -- Q8VC30 Triokinase/FMN cyclase Tkfc 1169.1 1036 1201.5 1051.6 1082.5 1090.4 1.05647387191813 0.307952403180284 0.0792570878405148 Nonsignificant None 2 Molecular Function:glycerone kinase activity (GO:0004371),Biological Process:glycerol metabolic process (GO:0006071) -- -- ko00051 Fructose and mannose metabolism ko00561 Glycerolipid metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko04622 RIG-I-like receptor signaling pathway Dihydroxyacetone kinase/glycerone kinase G Carbohydrate transport and metabolism ; IPR004006 [DhaK domain] ; IPR004007[DhaL domain] -- -- P01898 H-2 class I histocompatibility antigen, Q10 alpha chain H2-Q10 95.1 98.7 109.6 92.6 106.7 91.2 1.04440619621343 0.549999385775838 0.0626829219551421 Nonsignificant None -- -- major histocompatibility complex, class I -- ko04144 Endocytosis ko04145 Phagosome ko04218 Cellular senescence ko04514 Cell adhesion molecules (CAMs) ko04612 Antigen processing and presentation ko04940 Type I diabetes mellitus ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis ko05320 Autoimmune thyroid disease ko05330 Allograft rejection ko05332 Graft-versus-host disease ko05416 Viral myocarditis -- -- -- IPR003597 [Immunoglobulin C1-set] ; IPR011161[MHC class I-like antigen recognition-like] -- -- Q80YD1 ATP-dependent RNA helicase SUPV3L1, mitochondrial Supv3l1 637.3 601.4 585.8 633.4 680.3 647.7 0.930202916284287 0.0912843915660101 -0.104382632016578 Nonsignificant None -- -- ATP-dependent RNA helicase SUPV3L1/SUV3 3.6.4.13 -- Mitochondrial RNA helicase SUV3, DEAD-box superfamily A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR022192[Mitochondrial degradasome RNA helicase subunit, C-terminal domain] -- -- Q3UV17 Keratin, type II cytoskeletal 2 oral Krt76 128.9 120.1 37.4 366.4 124.9 37.1 0.542013626040878 0.475998752606921 -0.883598973982571 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) type II keratin, basic -- -- -- -- -- IPR001664 [Intermediate filament protein] ; IPR032444[Keratin type II head] -- -- Q8VHR5 Transcriptional repressor p66-beta Gatad2b 1032.5 947.3 985.8 911.8 911.9 945 1.07111640842273 0.0718997343806451 0.0991152800208789 Nonsignificant None 2 Molecular Function:zinc ion binding (GO:0008270),Molecular Function:sequence-specific DNA binding (GO:0043565) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR000679 [Zinc finger, GATA-type] ; IPR032346[Transcriptional repressor p66, coiled-coil MBD2-interaction domain] -- zf-GATA E9QL65 Conserved oligomeric Golgi complex subunit 3 Cog3 1126.4 1087.8 1199 1194.3 1213.9 1286 0.923934816739754 0.0943542232336661 -0.114137021258428 Nonsignificant None 3 Cellular Component:cis-Golgi network (GO:0005801),Biological Process:intracellular protein transport (GO:0006886),Cellular Component:membrane (GO:0016020) conserved oligomeric Golgi complex subunit 3 -- -- Subunit of cis-Golgi transport vesicle tethering complex - Sec34p U Intracellular trafficking, secretion, and vesicular transport ; IPR007265 [Conserved oligomeric Golgi complex, subunit 3] -- -- Q69Z99 Zinc finger protein 512 Znf512 322 317.4 411.9 363.5 407.9 398.9 0.898316670939076 0.303367350876334 -0.154703987271952 Nonsignificant None -- -- -- -- -- FOG: Zn-finger R General function prediction only ; -- -- zf-C2H2 Q99LM2 CDK5 regulatory subunit-associated protein 3 Cdk5rap3 1560.7 1597.9 1590 1470.9 1501.5 1433.9 1.07768422485986 0.0072185531567241 0.107934512074013 Nonsignificant None -- -- -- -- -- CDK5 activator-binding protein T Signal transduction mechanisms ; IPR008491 [Protein of unknown function DUF773] -- -- Q3U1H7 Sorting nexin Snx18 1435.2 1487.4 1511.4 1528.9 1468.5 1496.1 0.986758651385334 0.52443491555048 -0.0192308319156734 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:phosphatidylinositol binding (GO:0035091) sorting nexin-9/18/33 -- -- Sorting nexin SNX9/SH3PX1 and related proteins U Intracellular trafficking, secretion, and vesicular transport ; IPR001452 [SH3 domain] ; IPR001683[Phox homologous domain] ; IPR019497[Sorting nexin protein, WASP-binding domain] -- -- Q9CR26 Vacuolar protein sorting-associated protein VTA1 homolog Vta1 698.4 655.9 629.7 643.3 660.6 674.6 1.00277988375032 0.937502069967789 0.00400496041417433 Nonsignificant None -- -- vacuolar protein sorting-associated protein VTA1 -- ko04144 Endocytosis Uncharacterized conserved protein S Function unknown ; -- -- -- Q8R1M8 Mucosal pentraxin Mptx1 279.8 261.6 273.4 223.1 255.8 358.5 0.973011702889897 0.871086699643558 -0.0394709377744141 Nonsignificant None -- -- -- -- -- -- -- -- IPR001759 [Pentraxin-related] -- -- Q8K370 Acyl-CoA dehydrogenase family member 10 Acad10 634.2 571.3 644.6 807.6 715.8 767.7 0.807516040329972 0.0138011995941255 -0.308437177403194 Nonsignificant None 4 Molecular Function:acyl-CoA dehydrogenase activity (GO:0003995),Biological Process:metabolic process (GO:0008152),Molecular Function:flavin adenine dinucleotide binding (GO:0050660),Biological Process:oxidation-reduction process (GO:0055114) acyl-CoA dehydrogenase family member 10 -- -- Predicted acyl-CoA dehydrogenase R General function prediction only ; IPR002575 [Aminoglycoside phosphotransferase] ; IPR006091[Acyl-CoA oxidase/dehydrogenase, central domain] ; IPR009075[Acyl-CoA dehydrogenase/oxidase C-terminal] ; IPR013786[Acyl-CoA dehydrogenase/oxidase, N-terminal] ; IPR023214[HAD-like domain] -- -- Q3U6Q1 Uncharacterized protein Wbp11 529.9 527.9 602.8 559.5 604.8 601 0.940689967710871 0.289292786232922 -0.0882087765514895 Nonsignificant None 1 Biological Process:RNA processing (GO:0006396) WW domain-binding protein 11 -- ko03040 Spliceosome Uncharacterized conserved low complexity protein S Function unknown ; IPR019007 [WW domain binding protein 11] -- -- Q9D023 Mitochondrial pyruvate carrier 2 Mpc2 623.6 497.1 559.9 875 747.4 871.2 0.673965351299326 0.00819072432811484 -0.569253670829705 Nonsignificant None 2 Cellular Component:mitochondrial inner membrane (GO:0005743),Biological Process:mitochondrial pyruvate transport (GO:0006850) mitochondrial pyruvate carrier 2 -- -- Uncharacterized conserved protein S Function unknown ; IPR005336 [Mitochondrial pyruvate carrier] -- -- Q99K23 Ufm1-specific protease 2 Ufsp2 875.9 910 1023.7 1046.1 1038 1054.1 0.895290293798993 0.132325299494117 -0.159572549360755 Nonsignificant None -- -- UFM1-specific protease 2 3.4.22.- -- Uncharacterized conserved protein S Function unknown ; IPR012462 [Peptidase C78, ubiquitin fold modifier-specific peptidase 1/ 2] -- -- A2RSS6 Aspartylglucosaminidase Aga 248.3 243.5 258.5 318.9 323.5 331.3 0.770565882715415 0.000200177459746881 -0.376009783697717 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) N4-(beta-N-acetylglucosaminyl)-L-asparaginase 3.5.1.26 ko00511 Other glycan degradation ko04142 Lysosome Asparaginase E Amino acid transport and metabolism ; IPR000246 [Peptidase T2, asparaginase 2] -- -- Q8R0H9 ADP-ribosylation factor-binding protein GGA1 Gga1 933.1 870.1 794.6 861.9 897.4 888.5 0.981116398519526 0.708055547496562 -0.0275037886109156 Nonsignificant None 4 Cellular Component:intracellular (GO:0005622),Biological Process:intracellular protein transport (GO:0006886),Biological Process:vesicle-mediated transport (GO:0016192),Cellular Component:clathrin adaptor complex (GO:0030131) ADP-ribosylation factor-binding protein GGA -- ko04142 Lysosome Cytosolic sorting protein/ADP-ribosylation factor effector GGA U Intracellular trafficking, secretion, and vesicular transport ; IPR002014 [VHS domain] ; IPR004152[GAT domain] ; IPR008152[Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain] -- -- Q921Y0 MOB kinase activator 1A Mob1a 937.8 946.1 1123.2 1062.2 1073.3 996.8 0.960029371388437 0.555809143473203 -0.0588495501908236 Nonsignificant None -- -- MOB kinase activator 1 -- ko04390 Hippo signaling pathway ko04392 Hippo signaling pathway - multiple species Cell cycle-associated protein Mob1-1 D Cell cycle control, cell division, chromosome partitioning ; IPR005301 [MOB kinase activator family] -- -- P83887 Tubulin gamma-1 chain Tubg1 269.6 233.8 214.9 200.5 223.6 223.7 1.10882988576721 0.257227434655748 0.149038047388541 Nonsignificant None 1 Molecular Function:GTPase activity (GO:0003924) tubulin gamma -- ko05165 Human papillomavirus infection Gamma tubulin Z Cytoskeleton ; IPR003008 [Tubulin/FtsZ, GTPase domain] ; IPR018316[Tubulin/FtsZ, 2-layer sandwich domain] -- -- A0A0R4J0Z3 Aquaporin-4 Aqp4 412.9 340.6 411.9 468.7 522.6 382.5 0.848303974377639 0.215874180812073 -0.237346773794717 Nonsignificant None 3 Molecular Function:transporter activity (GO:0005215),Biological Process:transport (GO:0006810),Cellular Component:membrane (GO:0016020) aquaporin-4 -- ko04962 Vasopressin-regulated water reabsorption ko04976 Bile secretion Aquaporin (major intrinsic protein family) G Carbohydrate transport and metabolism ; IPR000425 [Major intrinsic protein] -- -- Q3UBB2 Vacuolar protein-sorting-associated protein 36 Vps36 1072.3 1152.8 1098.2 1214 1274 1170.9 0.908278444341195 0.0427684084132109 -0.138793452999796 Nonsignificant None -- -- ESCRT-II complex subunit VPS36 -- ko04144 Endocytosis Vacuolar sorting protein VPS36 U Intracellular trafficking, secretion, and vesicular transport ; IPR007286 [EAP30] -- -- A2AQ45 Formin-binding protein 1 Fnbp1 1296.8 1402.8 1356.2 1346.9 1412.8 1408.8 0.97296389588581 0.371553855239083 -0.0395418234810728 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) formin-binding protein 1 -- -- Cdc42-interacting protein CIP4 Z Cytoskeleton ; IPR001060 [FCH domain] ; IPR001452[SH3 domain] -- -- P59108 Copine-2 Cpne2 439.7 413.2 494.8 447.8 453 423.7 1.01751604379011 0.778246793400728 0.0250515425150566 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Copine T Signal transduction mechanisms ; IPR000008 [C2 domain] ; IPR010734[Copine] -- -- B2RTE3 Pre-mRNA-splicing factor 38A Prpf38a 620.8 667.7 617.1 578.2 591 615 1.06804169936106 0.107023923952941 0.0949679750095437 Nonsignificant None -- -- pre-mRNA-splicing factor 38A -- ko03040 Spliceosome Predicted PRP38-like splicing factor S Function unknown ; IPR005037 [Pre-mRNA-splicing factor 38] ; IPR024767[Pre-mRNA-splicing factor 38, C-terminal] -- -- Q9Z2A9 Glutathione hydrolase 5 proenzyme Ggt5 748.6 778.2 893.5 822.9 824.9 832 0.976006129526575 0.697804989128487 -0.0350378866383153 Nonsignificant None 2 Molecular Function:gamma-glutamyltransferase activity (GO:0003840),Biological Process:glutathione metabolic process (GO:0006749) -- -- ko00430 Taurine and hypotaurine metabolism ko00480 Glutathione metabolism ko00590 Arachidonic acid metabolism ko01100 Metabolic pathways Gamma-glutamyltransferase E Amino acid transport and metabolism ; IPR000101 [Gamma-glutamyltranspeptidase] -- -- Q6PAV2 Probable E3 ubiquitin-protein ligase HERC4 Herc4 1052.4 1067.7 1072.9 989.5 1014.8 1045.4 1.04698822835033 0.0507322157187891 0.0662452216420981 Nonsignificant None 1 Molecular Function:ubiquitin-protein transferase activity (GO:0004842) E3 ubiquitin-protein ligase HERC4 2.3.2.26 ko04120 Ubiquitin mediated proteolysis E3 ubiquitin protein ligase O Posttranslational modification, protein turnover, chaperones ; IPR000408 [Regulator of chromosome condensation, RCC1] ; IPR000569[HECT domain] -- -- Q05DK2 Ctr9 protein (Fragment) Ctr9 589.8 612.6 619.3 596.3 617.7 616.9 0.994975148833907 0.800344760766603 -0.00726760249923568 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) RNA polymerase-associated protein CTR9 -- -- TPR-containing nuclear phosphoprotein that regulates K(+) uptake P Inorganic ion transport and metabolism ; IPR019734 [Tetratricopeptide repeat] -- -- G3UZY2 Thioredoxin, mitochondrial (Fragment) Txn2 1074.7 1053.2 861.6 902.8 965.3 940.5 1.06440931424909 0.438360230187268 0.0900530400144665 Nonsignificant None 1 Biological Process:cell redox homeostasis (GO:0045454) thioredoxin 1 -- ko04621 NOD-like receptor signaling pathway ko05418 Fluid shear stress and atherosclerosis Thioredoxin-like protein O Posttranslational modification, protein turnover, chaperones ; IPR013766 [Thioredoxin domain] -- -- Q5JCT0 Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 Gcnt3 932.1 962.9 1237.5 1091.1 1069.2 1064.3 0.971438317930906 0.782135845990333 -0.0418057009710506 Nonsignificant None 2 Molecular Function:acetylglucosaminyltransferase activity (GO:0008375),Cellular Component:membrane (GO:0016020) N-acetylglucosaminyltransferase 3, mucin type 2.4.1.- ko00512 Mucin type O-glycan biosynthesis ko01100 Metabolic pathways Branching enzyme G Carbohydrate transport and metabolism ; IPR003406 [Glycosyl transferase, family 14] -- -- Q9D824 Pre-mRNA 3-end-processing factor FIP1 Fip1l1 488.4 496.8 395.4 389.3 405.7 384.9 1.17009916094584 0.113359323931916 0.226630797281179 Nonsignificant None -- -- pre-mRNA 3'-end-processing factor FIP1 -- ko03015 mRNA surveillance pathway Polyadenylation factor I complex, subunit FIP1 A RNA processing and modification ; IPR007854 [Pre-mRNA polyadenylation factor Fip1] -- -- B2RRI4 Adam17 protein Adam17 939.1 885.3 729.7 707.1 682.8 716.3 1.21265786724907 0.137255690619916 0.278172573668313 Nonsignificant None -- -- disintegrin and metalloproteinase domain-containing protein 17 3.4.24.86 ko04330 Notch signaling pathway ko05010 Alzheimer's disease Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases W Extracellular structures ; IPR001762 [Disintegrin domain] ; IPR002870[Peptidase M12B, propeptide] ; IPR032029[ADAM17, membrane-proximal domain] -- -- A2AP31 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 Ndufb6 574.7 534.2 508.8 596.3 633.9 576.7 0.895290276163595 0.0686593972386811 -0.159572577778914 Nonsignificant None -- -- NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 6 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit C Energy production and conversion ; IPR019174 [NADH dehydrogenase 1, beta subcomplex, subunit 6] -- -- K4PWM5 MDia3 isoform Diaph2 538.8 559.5 605 649.7 613.8 596.1 0.915949666594967 0.106717788749086 -0.126659773583694 Nonsignificant None 4 Molecular Function:actin binding (GO:0003779),Biological Process:cellular component organization (GO:0016043),Molecular Function:Rho GTPase binding (GO:0017048),Biological Process:actin cytoskeleton organization (GO:0030036) diaphanous 3 -- ko04810 Regulation of actin cytoskeleton RhoA GTPase effector DIA/Diaphanous TZ Signal transduction mechanisms ; Cytoskeleton ; IPR010465 [DRF autoregulatory] ; IPR010472[Formin, FH3 domain] ; IPR010473[Formin, GTPase-binding domain] ; IPR015425[Formin, FH2 domain] -- -- Q64520 Guanylate kinase Guk1 959.2 958 1094.6 1071.2 1029.3 1053.3 0.954974950852939 0.370240737328205 -0.0664652033664057 Nonsignificant None -- -- guanylate kinase 2.7.4.8 ko00230 Purine metabolism ko01100 Metabolic pathways Guanylate kinase F Nucleotide transport and metabolism ; IPR008145 [Guanylate kinase/L-type calcium channel beta subunit] -- -- Q4V9X0 Ppp3ca protein Ppp3ca 183.8 188.1 242.6 264.8 255.8 262.3 0.784902286371184 0.094527072736593 -0.349415032911374 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) serine/threonine-protein phosphatase 2B catalytic subunit 3.1.3.16 ko04010 MAPK signaling pathway ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04114 Oocyte meiosis ko04218 Cellular senescence ko04310 Wnt signaling pathway ko04360 Axon guidance ko04370 VEGF signaling pathway ko04380 Osteoclast differentiation ko04650 Natural killer cell mediated cytotoxicity ko04658 Th1 and Th2 cell differentiation ko04659 Th17 cell differentiation ko04660 T cell receptor signaling pathway ko04662 B cell receptor signaling pathway ko04720 Long-term potentiation ko04724 Glutamatergic synapse ko04728 Dopaminergic synapse ko04921 Oxytocin signaling pathway ko04922 Glucagon signaling pathway ko04924 Renin secretion ko05010 Alzheimer's disease ko05014 Amyotrophic lateral sclerosis (ALS) ko05031 Amphetamine addiction ko05152 Tuberculosis ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection Serine-threonine phosphatase 2B, catalytic subunit R General function prediction only ; IPR004843 [Calcineurin-like phosphoesterase domain, ApaH type] -- -- Q9DBG9 Tax1-binding protein 3 Tax1bp3 433.4 457.5 350.6 350.9 407.4 405.2 1.06703910614525 0.523897098786426 0.0936130507714922 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Tax interaction protein TIP1 M Cell wall/membrane/envelope biogenesis ; IPR001478 [PDZ domain] -- -- A2AUE1 DnaJ homolog subfamily C member 5 (Fragment) Dnajc5 887.4 919.1 1510 1481.1 1498 1541.9 0.733576642335766 0.184902452736815 -0.446980391781598 Nonsignificant None -- -- DnaJ homolog subfamily C member 5 -- ko04141 Protein processing in endoplasmic reticulum Molecular chaperone (DnaJ superfamily) O Posttranslational modification, protein turnover, chaperones ; IPR001623 [DnaJ domain] -- -- E9Q1Y3 Apolipoprotein B-100 (Fragment) Apob 812.2 947.1 780.3 516.6 586.6 568.3 1.51935387376608 0.00635139222520999 0.603457928081361 Significant up 2 Molecular Function:lipid transporter activity (GO:0005319),Biological Process:lipid transport (GO:0006869) apolipoprotein B -- ko04975 Fat digestion and absorption ko04977 Vitamin digestion and absorption ko04979 Cholesterol metabolism Predicted lipoprotein I Lipid transport and metabolism ; IPR001747 [Lipid transport protein, N-terminal] ; IPR009454[Lipid transport, open beta-sheet] ; IPR015255[Vitellinogen, open beta-sheet] ; IPR022176[Apolipoprotein B100 C-terminal] -- -- Q3TIY5 Uncharacterized protein Pkp2 872.4 871.2 948.5 945.2 973.6 923.1 0.947288785671558 0.165236456444792 -0.078123789421816 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) plakophilin 2 -- ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) Neural adherens junction protein Plakophilin and related Armadillo repeat proteins TW Signal transduction mechanisms ; Extracellular structures ; IPR000225 [Armadillo] -- -- H3BK03 Paraoxonase (Fragment) Pon1 1127.5 1237.3 956.7 668.4 642.9 660.6 1.68441604543841 0.0304825907409491 0.752248523533541 Significant up 1 Molecular Function:arylesterase activity (GO:0004064) -- -- -- -- -- IPR002640 [Arylesterase] -- -- J3QJX3 Protein sel-1 homolog 1 Sel1l 775.2 723.3 735 703.2 730.7 780.7 1.00853427255486 0.830621617425562 0.0122601112238536 Nonsignificant None -- -- SEL1 protein -- ko04141 Protein processing in endoplasmic reticulum Extracellular protein SEL-1 and related proteins MOT Cell wall/membrane/envelope biogenesis ; Posttranslational modification, protein turnover, chaperones ; Signal transduction mechanisms ; IPR006597 [Sel1-like repeat] -- -- P06537 Glucocorticoid receptor Nr3c1 383.4 391.3 438.5 367.2 358.6 329.3 1.14984361671879 0.0633846981235422 0.201437662277708 Nonsignificant None 9 Molecular Function:DNA binding (GO:0003677),Molecular Function:glucocorticoid receptor activity (GO:0004883),Molecular Function:steroid binding (GO:0005496),Cellular Component:nucleus (GO:0005634),Molecular Function:zinc ion binding (GO:0008270),Biological Process:glucocorticoid receptor signaling pathway (GO:0042921),Biological Process:steroid hormone mediated signaling pathway (GO:0043401),Biological Process:glucocorticoid mediated signaling pathway (GO:0043402),Molecular Function:sequence-specific DNA binding (GO:0043565) glucocorticoid receptor -- ko04080 Neuroactive ligand-receptor interaction FOG: Hormone receptors T Signal transduction mechanisms ; IPR000536 [Nuclear hormone receptor, ligand-binding domain] ; IPR001409[Glucocorticoid receptor] ; IPR001628[Zinc finger, nuclear hormone receptor-type] -- ESR-like Q8CGC6 RNA-binding protein 28 Rbm28 1182.2 1183.4 1059.5 1051.4 1050.3 1030.3 1.09358237547893 0.0789769023216883 0.129061897312242 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) nucleolar protein 4 -- ko03008 Ribosome biogenesis in eukaryotes Nucleolar protein fibrillarin NOP77 (RRM superfamily) A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- Q0VEI2 Cell cycle control protein Tmem30b 753.8 728.8 633.6 643.3 783.1 706.5 0.992170284589057 0.923615586743997 -0.0113403455966818 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) -- -- -- Cell cycle control protein DKT Cell cycle control, cell division, chromosome partitioning ; Transcription ; Signal transduction mechanisms ; IPR005045 [CDC50/LEM3 family] -- -- Q6NV83 U2 snRNP-associated SURP motif-containing protein U2surp 912.3 880.6 759.4 834.1 745.2 782 1.08088764663533 0.297896991687747 0.112216569264892 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:RNA binding (GO:0003723),Biological Process:RNA processing (GO:0006396) U2-associated protein SR140 -- ko03040 Spliceosome Predicted splicing regulator, contains RRM, SWAP and RPR domains R General function prediction only ; IPR000061 [SWAP/Surp] ; IPR000504[RNA recognition motif domain] ; IPR013170[mRNA splicing factor Cwf21 domain] -- -- Q6Y642 Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial 955.8 935 985.5 1098.8 1067.8 1056.4 0.892429413589823 0.00396372207862861 -0.164190030721647 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:mitochondrial membrane (GO:0031966) synaptojanin-2-binding protein -- -- FOG: PDZ domain S Function unknown ; IPR001478 [PDZ domain] ; IPR020164[Cytochrome c oxidase assembly protein COX16] -- -- Q8R349 Cell division cycle protein 16 homolog Cdc16 1009.7 1018.3 1098.5 944 911.4 963.5 1.10912057894924 0.0330878200115986 0.149416217795138 Nonsignificant None -- -- anaphase-promoting complex subunit 6 -- ko04110 Cell cycle ko04114 Oocyte meiosis ko04120 Ubiquitin mediated proteolysis ko04914 Progesterone-mediated oocyte maturation ko05166 HTLV-I infection Anaphase-promoting complex (APC), Cdc16 subunit DO Cell cycle control, cell division, chromosome partitioning ; Posttranslational modification, protein turnover, chaperones ; -- -- -- Q8C0L8 Conserved oligomeric Golgi complex subunit 5 Cog5 601.1 661.3 607.5 695.7 678.8 605.6 0.944346245139134 0.33570633198475 -0.0826121732682747 Nonsignificant None 2 Biological Process:intra-Golgi vesicle-mediated transport (GO:0006891),Cellular Component:Golgi transport complex (GO:0017119) conserved oligomeric Golgi complex subunit 5 -- -- Predicted Golgi transport complex 1 protein U Intracellular trafficking, secretion, and vesicular transport ; IPR019465 [Conserved oligomeric Golgi complex subunit 5] -- -- Q9Z2L6 Multiple inositol polyphosphate phosphatase 1 Minpp1 355.9 329.6 351.4 344.2 385.7 405.9 0.91292481070611 0.172847872198818 -0.131432051423054 Nonsignificant None 1 Molecular Function:acid phosphatase activity (GO:0003993) -- -- ko00010 Glycolysis / Gluconeogenesis ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways Multiple inositol polyphosphate phosphatase R General function prediction only ; IPR000560 [Histidine phosphatase superfamily, clade-2] -- -- Q8CEE7 Retinol dehydrogenase 13 Rdh13 531.4 514.2 521.2 649.9 567.8 612.1 0.856268444638758 0.0224389037826625 -0.223864934902291 Nonsignificant None -- -- retinol dehydrogenase 13 1.1.1.300 -- Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Q Secondary metabolites biosynthesis, transport and catabolism ; IPR002347 [Short-chain dehydrogenase/reductase SDR] -- -- Q9Z2L7 Cytokine receptor-like factor 3 Crlf3 674 674.5 607.2 562.8 554 536.6 1.18283536954155 0.013025213963965 0.242249289168834 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- B2RR83 3-5 RNA helicase YTHDC2 Ythdc2 457.1 422 453.1 415 414.6 404.1 1.0798411283132 0.0479505430890474 0.110819071412232 Nonsignificant None 4 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:RNA binding (GO:0003723),Molecular Function:helicase activity (GO:0004386),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase YTHDC2 3.6.4.13 -- ATP-dependent RNA helicase A A RNA processing and modification ; IPR001374 [R3H domain] ; IPR001650[Helicase, C-terminal] ; IPR007275[YTH domain] ; IPR007502[Helicase-associated domain] ; IPR011545[DEAD/DEAH box helicase domain] ; IPR011709[Domain of unknown function DUF1605] -- -- Q9DAM7 Transmembrane protein 263 Tmem263 938.3 912.1 911.4 860.7 883.6 850 1.06456462244151 0.0136770442325796 0.0902635286029281 Nonsignificant None -- -- -- -- -- -- -- -- IPR028153 [Transmembrane protein C12orf23, UPF0444] -- -- Q9CRB3 5-hydroxyisourate hydrolase Urah 1122.4 1188.2 903.4 709.7 752.4 720.7 1.47242074399853 0.0545223748410029 0.558189980189814 Nonsignificant None -- -- 5-hydroxyisourate hydrolase 3.5.2.17 ko00230 Purine metabolism ko01100 Metabolic pathways Transthyretin and related proteins I Lipid transport and metabolism ; IPR023416 [Transthyretin/hydroxyisourate hydrolase, superfamily] -- -- Q3U0B3 Dehydrogenase/reductase SDR family member 11 Dhrs11 722.9 676 728.6 1003.2 1086.7 1041.1 0.679495368891728 0.000337293404880539 -0.557464376565345 Nonsignificant None -- -- -- -- -- Predicted dehydrogenase Q Secondary metabolites biosynthesis, transport and catabolism ; IPR002347 [Short-chain dehydrogenase/reductase SDR] -- -- Q3UJU9 Regulator of microtubule dynamics protein 3 Rmdn3 877.1 825.6 890.5 1009.7 969.5 980.1 0.876288311424999 0.00620820872856895 -0.190522479593379 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q3UAI3 Platelet glycoprotein 4 Cd36 611.7 592.6 831.7 747.2 748.3 847.7 0.868897234551041 0.288006213291119 -0.202742536916309 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) CD36 antigen -- ko03320 PPAR signaling pathway ko04145 Phagosome ko04152 AMPK signaling pathway ko04512 ECM-receptor interaction ko04640 Hematopoietic cell lineage ko04920 Adipocytokine signaling pathway ko04931 Insulin resistance ko04975 Fat digestion and absorption ko04979 Cholesterol metabolism ko05144 Malaria Plasma membrane glycoprotein CD36 and related membrane receptors T Signal transduction mechanisms ; IPR002159 [CD36 family] -- -- Q9R099 Transducin beta-like protein 2 Tbl2 837.9 902.6 944.9 910.8 882.3 803.2 1.03431806801987 0.543322106195124 0.0486799038271948 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- WD40 repeat protein R General function prediction only ; IPR001680 [WD40 repeat] -- -- P00375 Dihydrofolate reductase Dhfr 1406.1 1450.4 1502.4 1594.4 1565.7 1444.2 0.946701995960298 0.202988235615158 -0.0790177310838083 Nonsignificant None 4 Molecular Function:dihydrofolate reductase activity (GO:0004146),Biological Process:glycine biosynthetic process (GO:0006545),Biological Process:nucleotide biosynthetic process (GO:0009165),Biological Process:oxidation-reduction process (GO:0055114) dihydrofolate reductase 1.5.1.3 ko00670 One carbon pool by folate ko00790 Folate biosynthesis ko01100 Metabolic pathways ko01523 Antifolate resistance Dihydrofolate reductase H Coenzyme transport and metabolism ; IPR001796 [Dihydrofolate reductase domain] -- -- Q99MR3 Solute carrier family 12 member 9 Slc12a9 263.3 272.6 221.5 264.4 280.2 285.6 0.912310286677909 0.225563425452106 -0.132403510719188 Nonsignificant None 5 Molecular Function:transporter activity (GO:0005215),Biological Process:transport (GO:0006810),Biological Process:ion transport (GO:0006811),Cellular Component:membrane (GO:0016020),Biological Process:transmembrane transport (GO:0055085) solute carrier family 12 (potassium/chloride transporters), member 9 -- -- Amino acid transporters E Amino acid transport and metabolism ; IPR004841 [Amino acid permease/ SLC12A domain] ; IPR018491[SLC12A transporter, C-terminal] -- -- Q8BH58 TIP41-like protein Tiprl 737.5 725 811.3 743.7 721.5 782.3 1.01170189098999 0.799248133040575 0.0167842468028689 Nonsignificant None -- -- type 2A phosphatase activator TIP41 -- Uncharacterized conserved protein S Function unknown ; IPR007303 [TIP41-like protein] -- -- Q9JHI5 Isovaleryl-CoA dehydrogenase, mitochondrial Ivd 761.6 666.8 727.8 938.3 886.5 980.4 0.768643946955654 0.00508027760224436 -0.379612630531333 Nonsignificant None 4 Molecular Function:acyl-CoA dehydrogenase activity (GO:0003995),Biological Process:metabolic process (GO:0008152),Molecular Function:flavin adenine dinucleotide binding (GO:0050660),Biological Process:oxidation-reduction process (GO:0055114) isovaleryl-CoA dehydrogenase 1.3.8.4 ko00280 Valine, leucine and isoleucine degradation ko01100 Metabolic pathways Isovaleryl-CoA dehydrogenase EI Amino acid transport and metabolism ; Lipid transport and metabolism ; IPR006091 [Acyl-CoA oxidase/dehydrogenase, central domain] ; IPR009075[Acyl-CoA dehydrogenase/oxidase C-terminal] ; IPR013786[Acyl-CoA dehydrogenase/oxidase, N-terminal] -- -- G8JL35 MOB-like protein phocein (Fragment) Mob4 762.2 770 724.3 794 730.3 812.4 0.965678093037189 0.402831231446469 -0.05038574534595 Nonsignificant None -- -- -- -- -- Cell cycle-associated protein D Cell cycle control, cell division, chromosome partitioning ; IPR005301 [MOB kinase activator family] -- -- A0A0R4J0Q6 E3 ubiquitin-protein ligase TRIM56 Trim56 542.4 493.5 427.5 395.5 414 425.4 1.18503522552433 0.0912830179546392 0.244929944299861 Nonsignificant None 2 Cellular Component:intracellular (GO:0005622),Molecular Function:zinc ion binding (GO:0008270) tripartite motif-containing protein 56 2.3.2.27 -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR000315 [B-box-type zinc finger] ; IPR027370[RING-type zinc-finger, LisH dimerisation motif] -- -- Q99L43 Phosphatidate cytidylyltransferase 2 Cds2 458.5 441.3 470.9 536.1 514.5 538.3 0.862672289004972 0.00315620900017907 -0.213115480809794 Nonsignificant None -- -- phosphatidate cytidylyltransferase 2.7.7.41 ko00564 Glycerophospholipid metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system CDP-diacylglycerol synthase I Lipid transport and metabolism ; -- -- -- Q8K0Z7 Translational activator of cytochrome c oxidase 1 Taco1 557 549 667.1 686.5 688.2 641.1 0.879601150907828 0.120440118463907 -0.18507860300925 Nonsignificant None -- -- translational activator of cytochrome c oxidase 1 -- -- Uncharacterized conserved protein S Function unknown ; IPR002876 [Transcriptional regulator TACO1-like] -- -- E3SRG8 Mothers against decapentaplegic homolog Smad4 1400.3 1330 1372.7 1356.3 1365.3 1331.9 1.01221166892809 0.508503538596502 0.0175110111601682 Nonsignificant None 1 Cellular Component:intracellular (GO:0005622) mothers against decapentaplegic homolog 4 -- ko04068 FoxO signaling pathway ko04110 Cell cycle ko04310 Wnt signaling pathway ko04350 TGF-beta signaling pathway ko04371 Apelin signaling pathway ko04390 Hippo signaling pathway ko04520 Adherens junction ko04550 Signaling pathways regulating pluripotency of stem cells ko04659 Th17 cell differentiation ko04933 AGE-RAGE signaling pathway in diabetic complications ko05161 Hepatitis B ko05166 HTLV-I infection ko05200 Pathways in cancer ko05210 Colorectal cancer ko05212 Pancreatic cancer ko05220 Chronic myeloid leukemia ko05225 Hepatocellular carcinoma ko05226 Gastric cancer TGFbeta receptor signaling protein SMAD and related proteins TK Signal transduction mechanisms ; Transcription ; IPR001132 [SMAD domain, Dwarfin-type] ; IPR003619[MAD homology 1, Dwarfin-type] -- MH1 B9EIU2 C4a protein C4a 86.5 87.7 80.2 94.2 84.3 89.2 0.950317519611505 0.295261603707193 -0.0735184683564225 Nonsignificant None 3 Molecular Function:endopeptidase inhibitor activity (GO:0004866),Cellular Component:extracellular region (GO:0005576),Cellular Component:extracellular space (GO:0005615) complement component 4 -- ko04610 Complement and coagulation cascades ko05133 Pertussis ko05150 Staphylococcus aureus infection ko05322 Systemic lupus erythematosus Alpha-macroglobulin O Posttranslational modification, protein turnover, chaperones ; IPR000020 [Anaphylatoxin/fibulin] ; IPR001599[Alpha-2-macroglobulin] ; IPR002890[Alpha-2-macroglobulin, N-terminal] ; IPR009048[Alpha-macroglobulin, receptor-binding] ; IPR011625[Alpha-2-macroglobulin, N-terminal 2] ; IPR011626[Alpha-macroglobulin complement component] ; IPR018933[Netrin module, non-TIMP type] ; IPR019565[Alpha-2-macroglobulin, thiol-ester bond-forming] -- -- P35230 Regenerating islet-derived protein 3-beta Reg3b 1872.5 2196.5 9363.3 508.6 532.5 481.7 8.82079064880483 0.245893211223611 3.14090797709648 Nonsignificant None -- -- -- -- -- C-type lectin TV Signal transduction mechanisms ; Defense mechanisms ; IPR001304 [C-type lectin-like] -- -- G3UYE5 Polyadenylate-binding protein-interacting protein 1 Paip1 1339.5 1251.9 1235.6 1211.6 1216.1 1311.3 1.02353570473389 0.556720305001601 0.0335614298103271 Nonsignificant None 2 Molecular Function:RNA binding (GO:0003723),Molecular Function:protein binding (GO:0005515) polyadenylate-binding protein-interacting protein 1 -- ko03013 RNA transport Translation initiation factor 4F, ribosome/mRNA-bridging subunit (eIF-4G) J Translation, ribosomal structure and biogenesis ; IPR003890 [MIF4G-like, type 3] ; IPR009818[Ataxin-2, C-terminal] -- -- Q542P8 Uncharacterized protein Emg1 366.7 405.6 263.8 264.4 258 285.6 1.28230198019802 0.152595725002087 0.358736054492407 Nonsignificant None 1 Molecular Function:methyltransferase activity (GO:0008168) rRNA small subunit pseudouridine methyltransferase Nep1 2.1.1.260 ko03008 Ribosome biogenesis in eukaryotes Protein required for 18S rRNA maturation and 40S ribosome biogenesis J Translation, ribosomal structure and biogenesis ; IPR005304 [Ribosomal biogenesis, methyltransferase, EMG1/NEP1] -- -- Q3U6X7 Protein kinase domain-containing protein Cdk2 715.1 723.4 652 601.4 597.8 598.6 1.16281010123484 0.0491591014069889 0.217615509213307 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) cyclin-dependent kinase 2 2.7.11.22 ko04068 FoxO signaling pathway ko04110 Cell cycle ko04114 Oocyte meiosis ko04115 p53 signaling pathway ko04151 PI3K-Akt signaling pathway ko04218 Cellular senescence ko04914 Progesterone-mediated oocyte maturation ko05161 Hepatitis B ko05162 Measles ko05165 Human papillomavirus infection ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05215 Prostate cancer ko05222 Small cell lung cancer ko05226 Gastric cancer Protein kinase PCTAIRE and related kinases R General function prediction only ; IPR000719 [Protein kinase domain] -- -- D3Z0T5 Protein canopy homolog 4 (Fragment) Cnpy4 513.2 514.4 545.7 518 516.9 529.8 1.00549626126414 0.814039401243879 0.00790771728154232 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR021852 [Domain of unknown function DUF3456] -- -- Q8BND5 Sulfhydryl oxidase 1 Qsox1 583.5 560.1 537.1 460 473.1 482.6 1.18718655082291 0.00406805203768764 0.247546653430022 Nonsignificant None 3 Molecular Function:thiol oxidase activity (GO:0016972),Biological Process:cell redox homeostasis (GO:0045454),Biological Process:oxidation-reduction process (GO:0055114) thiol oxidase 1.8.3.2 -- FAD-dependent sulfhydryl oxidase/quiescin and related proteins D Cell cycle control, cell division, chromosome partitioning ; IPR013766 [Thioredoxin domain] ; IPR017905[ERV/ALR sulfhydryl oxidase domain] -- -- Q7TMR0 Lysosomal Pro-X carboxypeptidase Prcp 335.7 333.8 389.3 448.8 472 465.4 0.763814745346992 0.00496313532608458 -0.388705323612922 Nonsignificant None 2 Biological Process:proteolysis (GO:0006508),Molecular Function:serine-type peptidase activity (GO:0008236) lysosomal Pro-X carboxypeptidase 3.4.16.2 ko04614 Renin-angiotensin system ko04974 Protein digestion and absorption Prolylcarboxypeptidase (angiotensinase C) OR Posttranslational modification, protein turnover, chaperones ; General function prediction only ; IPR008758 [Peptidase S28] -- -- Q9CQ21 Malignant T-cell-amplified sequence 2 Mcts2 67.4 66.8 65.1 59 62 68.1 1.05393971443681 0.286125824786218 0.0757923468892968 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) -- -- -- Predicted RNA-binding protein with PUA domain J Translation, ribosomal structure and biogenesis ; IPR002478 [PUA domain] -- -- Q9DCA5 Ribosome biogenesis protein BRX1 homolog Brix1 1041.5 1037.1 993 806.8 779.4 889.9 1.24049917208513 0.00563369709597027 0.310920772369344 Nonsignificant None -- -- ribosome biogenesis protein BRX1 -- -- RNA-binding protein required for biogenesis of the ribosomal 60S subunit J Translation, ribosomal structure and biogenesis ; IPR007109 [Brix domain] -- -- Q7TQK5 Coiled-coil domain-containing protein 93 Ccdc93 815.6 798.6 851.5 861.5 871.6 851.6 0.953959840600456 0.0755218192402204 -0.0679995613463756 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019159 [Coiled-coil domain of unkwon function DUF2037] -- -- E9Q7A5 TraB domain-containing protein (Fragment) Trabd 297.8 234.1 216.5 244.4 264.2 292.5 0.934215453751092 0.569262180385092 -0.0981727845537293 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein, contains TraB domain T Signal transduction mechanisms ; IPR002816 [Pheromone shutdown, TraB] -- -- A0A286YDB8 Elongator complex protein 3 Elp3 893.4 856.6 839.6 769.9 811.1 777.3 1.09807912479328 0.0191980934184232 0.134982015029812 Nonsignificant None 3 Molecular Function:catalytic activity (GO:0003824),Molecular Function:N-acetyltransferase activity (GO:0008080),Molecular Function:iron-sulfur cluster binding (GO:0051536) elongator complex protein 3 2.3.1.48 -- RNA polymerase II elongator complex, subunit ELP3/histone acetyltransferase BK Chromatin structure and dynamics ; Transcription ; IPR000182 [GNAT domain] ; IPR007197[Radical SAM] ; IPR032432[Radical SAM, C-terminal extension] -- -- Q542P5 Uncharacterized protein Cbr2 689.1 666.3 378.3 514.1 670.1 590 0.97717281028069 0.907984369243362 -0.0333143735447215 Nonsignificant None -- -- carbonyl reductase 2 1.1.1.184 ko00590 Arachidonic acid metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko01100 Metabolic pathways Diacetyl reductase/L-xylulose reductase Q Secondary metabolites biosynthesis, transport and catabolism ; -- -- -- A0A1S6GWI6 Ribosomal RNA-processing protein 40 Exosc3 1012.7 1065.2 1075.4 1073.6 1058.9 1033.9 0.995862809499747 0.856320591708342 -0.00598108521127312 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) exosome complex component RRP40 -- ko03018 RNA degradation Exosomal 3'-5' exoribonuclease complex subunit Rrp40 J Translation, ribosomal structure and biogenesis ; IPR004088 [K Homology domain, type 1] -- -- Q8VBT9 Tether containing UBX domain for GLUT4 Aspscr1 867 903.8 1134.2 1023.5 1143 1035.9 0.907132150886835 0.341027012493831 -0.140615357208285 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) tether containing UBX domain for GLUT4 -- ko05202 Transcriptional misregulation in cancer Predicted ubiquitin regulatory protein O Posttranslational modification, protein turnover, chaperones ; IPR001012 [UBX domain] ; IPR021569[TUG ubiquitin-like domain] -- -- Q3U422 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial Ndufv3 2226 2224.6 2928.3 2600.1 2687.7 2841.6 0.907680763647994 0.364475562712994 -0.139743112000349 Nonsignificant None 2 Cellular Component:mitochondrion (GO:0005739),Cellular Component:mitochondrial respiratory chain complex I (GO:0005747) NADH dehydrogenase (ubiquinone) flavoprotein 3 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease -- -- -- IPR026193 [NADH-ubiquinone oxidoreductase flavoprotein 3] -- -- Q61712 DnaJ homolog subfamily C member 1 Dnajc1 906.2 909.2 916.6 821 849 863.2 1.07847781462182 0.00657676451781901 0.108996499109141 Nonsignificant None -- -- DnaJ homolog subfamily C member 1 -- ko04141 Protein processing in endoplasmic reticulum Zuotin and related molecular chaperones (DnaJ superfamily), contains DNA-binding domains O Posttranslational modification, protein turnover, chaperones ; IPR001005 [SANT/Myb domain] ; IPR001623[DnaJ domain] -- MYB Q69ZP5 Endoplasmic reticulum-Golgi intermediate compartment protein (Fragment) Ergic1 1155 1117.1 1398.5 1457.3 1309.4 1432.5 0.874118879786626 0.150721347418709 -0.194098595921625 Nonsignificant None -- -- endoplasmic reticulum-Golgi intermediate compartment protein 1 -- -- COPII vesicle protein U Intracellular trafficking, secretion, and vesicular transport ; IPR012936 [Endoplasmic reticulum vesicle transporter, C-terminal] -- -- Q8C7V8 Coiled-coil domain-containing protein 134 Ccdc134 518.4 474.7 433 463.2 490.4 494.8 0.984603700635184 0.793467466270361 -0.0223849329318926 Nonsignificant None -- -- -- -- -- -- -- -- IPR026321 [Coiled-coil domain-containing protein 134] -- -- P60840 Alpha-endosulfine Ensa 713.4 756.3 530.8 509 468.5 525.2 1.3312703799827 0.0800950230548588 0.412803611253906 Nonsignificant None -- -- -- -- -- Regulator of ATP-sensitive K+ channels Alpha-endosulfine/ARPP-19 and related cAMP-regulated phosphoproteins TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR006760 [Endosulphine] -- -- Q60855 Receptor-interacting serine/threonine-protein kinase 1 Ripk1 639.4 645.6 569 674.9 632.8 608.8 0.967388468562484 0.541487825427611 -0.047832754174987 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein binding (GO:0005515),Biological Process:protein phosphorylation (GO:0006468),Biological Process:signal transduction (GO:0007165) receptor-interacting serine/threonine-protein kinase 1 2.7.11.1 ko04064 NF-kappa B signaling pathway ko04210 Apoptosis ko04217 Necroptosis ko04620 Toll-like receptor signaling pathway ko04621 NOD-like receptor signaling pathway ko04622 RIG-I-like receptor signaling pathway ko04623 Cytosolic DNA-sensing pathway ko04668 TNF signaling pathway ko05160 Hepatitis C ko05169 Epstein-Barr virus infection Tyrosine kinase specific for activated (GTP-bound) p21cdc42Hs T Signal transduction mechanisms ; IPR000488 [Death domain] ; IPR001245[Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR025735[RHIM domain] -- -- A0A2R8VK76 Cleavage and polyadenylation-specificity factor subunit 1 Cpsf1 1268.3 1255.3 1422.1 1367.1 1397.5 1381.3 0.951711329265057 0.286284800027218 -0.071404049706832 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Cellular Component:nucleus (GO:0005634) cleavage and polyadenylation specificity factor subunit 1 -- ko03015 mRNA surveillance pathway mRNA cleavage and polyadenylation factor II complex, subunit CFT1 (CPSF subunit) A RNA processing and modification ; IPR004871 [Cleavage/polyadenylation specificity factor, A subunit, C-terminal] -- -- P33609 DNA polymerase alpha catalytic subunit Pola1 326.8 334.3 340.4 300.4 293.1 293 1.1297236322617 0.00116517205004285 0.175969884914019 Nonsignificant None 6 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:nucleoside binding (GO:0001882),Molecular Function:DNA binding (GO:0003677),Molecular Function:DNA-directed DNA polymerase activity (GO:0003887),Biological Process:DNA replication (GO:0006260),Molecular Function:3'-5' exonuclease activity (GO:0008408) DNA polymerase alpha subunit A 2.7.7.7 ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways ko03030 DNA replication DNA polymerase alpha, catalytic subunit L Replication, recombination and repair ; IPR006133 [DNA-directed DNA polymerase, family B, exonuclease domain] ; IPR006134[DNA-directed DNA polymerase, family B, multifunctional domain] ; IPR015088[Zinc finger, DNA-directed DNA polymerase, family B, alpha] ; IPR024647[DNA polymerase alpha catalytic subunit, N-terminal domain] -- -- Q9DCU6 39S ribosomal protein L4, mitochondrial Mrpl4 576.4 537 593.5 557.9 573.7 554.7 1.01221609440788 0.718254478739149 0.0175173187379044 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L4 -- ko03010 Ribosome Mitochondrial/chloroplast ribosomal protein L4 J Translation, ribosomal structure and biogenesis ; IPR002136 [Ribosomal protein L4/L1e] -- -- Q9EPK2 Protein XRP2 Rp2 498 538.2 575.9 548.7 593 592.1 0.929807359557042 0.205008519756378 -0.104996249849556 Nonsignificant None -- -- protein XRP2 -- -- Beta-tubulin folding cofactor C O Posttranslational modification, protein turnover, chaperones ; IPR012945 [Tubulin binding cofactor C-like domain] -- -- Q9Z2E1 Methyl-CpG-binding domain protein 2 Mbd2 786.3 768.4 759.1 733.9 756.6 741.8 1.03650942973615 0.0591420568278028 0.051733241552675 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634) methyl-CpG-binding domain protein 2 -- -- Methyl-CpG binding transcription regulators KB Transcription ; Chromatin structure and dynamics ; IPR001739 [Methyl-CpG DNA binding] ; IPR025884[Methyl-CpG binding protein 2/3, C-terminal domain] ; IPR032343[Methyl-CpG-binding domain protein 2/3, p55-binding region] -- MBD Q3TWZ9 Clathrin light chain Cltb 1590.5 1541.4 1561.7 1545.2 1595.3 1537.4 1.00335620684495 0.831627002306352 0.00483387575780647 Nonsignificant None 5 Molecular Function:structural molecule activity (GO:0005198),Biological Process:intracellular protein transport (GO:0006886),Biological Process:vesicle-mediated transport (GO:0016192),Cellular Component:clathrin coat of trans-Golgi network vesicle (GO:0030130),Cellular Component:clathrin coat of coated pit (GO:0030132) clathrin light chain B -- ko04142 Lysosome ko04144 Endocytosis ko04721 Synaptic vesicle cycle ko04961 Endocrine and other factor-regulated calcium reabsorption ko05016 Huntington's disease ko05100 Bacterial invasion of epithelial cells Vesicle coat protein clathrin, light chain U Intracellular trafficking, secretion, and vesicular transport ; IPR000996 [Clathrin light chain] -- -- Q9ER05 Chymopasin Ctrl 567 498.7 525.6 631.7 807.6 602.3 0.779437695924765 0.0889381152515865 -0.359494388670867 Nonsignificant None 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) chymotrypsin-like protease 3.4.21.- ko04972 Pancreatic secretion ko04974 Protein digestion and absorption Trypsin E Amino acid transport and metabolism ; IPR001254 [Serine proteases, trypsin domain] -- -- Q6PAR5 GTPase-activating protein and VPS9 domain-containing protein 1 Gapvd1 1159.3 1196.7 1370.5 1378.1 1301.3 1293.7 0.937932596712894 0.308001489621799 -0.0924438457949634 Nonsignificant None 1 Biological Process:regulation of GTPase activity (GO:0043087) -- -- -- Vacuolar assembly/sorting protein VPS9 U Intracellular trafficking, secretion, and vesicular transport ; IPR001936 [Ras GTPase-activating protein] ; IPR003123[VPS9 domain] -- -- E9Q827 cAMP-regulated phosphoprotein 19 Arpp19 956.3 1012 838.5 668.4 689.3 646.2 1.40066869604272 0.00705772014571828 0.486115751557753 Nonsignificant None -- -- -- -- -- Regulator of ATP-sensitive K+ channels Alpha-endosulfine/ARPP-19 and related cAMP-regulated phosphoproteins TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR006760 [Endosulphine] -- -- Q9DBY8 Nuclear valosin-containing protein-like Nvl 552.8 526.5 490.2 495.8 472.7 482.6 1.08159327406795 0.110884402433023 0.113158085302459 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) ribosome biogenesis ATPase -- ko03008 Ribosome biogenesis in eukaryotes Nuclear AAA ATPase (VCP subfamily) O Posttranslational modification, protein turnover, chaperones ; IPR003959 [ATPase, AAA-type, core] ; IPR031996[NVL2, nucleolin binding domain] -- -- D3YWT0 Signal peptidase complex catalytic subunit SEC11 Sec11a 1687.3 1422.1 1552.6 1503.1 1484.9 1472.7 1.04512744636492 0.47367995881397 0.0636788801315739 Nonsignificant None -- -- signal peptidase I 3.4.21.89 ko03060 Protein export Signal peptidase I U Intracellular trafficking, secretion, and vesicular transport ; IPR019759 [Peptidase S24/S26A/S26B] -- -- Q3THX4 Uncharacterized protein Vps45 329.1 293.7 363.8 336.2 348.1 331.4 0.971349808014177 0.665767827490026 -0.041937154129856 Nonsignificant None 2 Biological Process:vesicle docking involved in exocytosis (GO:0006904),Biological Process:vesicle-mediated transport (GO:0016192) vacuolar protein sorting-associated protein 45 -- ko04144 Endocytosis Vacuolar sorting protein VPS45/Stt10 (Sec1 family) U Intracellular trafficking, secretion, and vesicular transport ; IPR001619 [Sec1-like protein] -- -- P60824 Cold-inducible RNA-binding protein Cirbp 444.4 486.4 585 491.1 525.7 560.1 0.961253091508656 0.682017246005183 -0.0570117619200138 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) cold-inducible RNA-binding protein -- -- FOG: RRM domain R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- A0A3B2WAQ7 Ankyrin repeat and SAM domain containing 1 Anks1 594.8 619.7 763.3 807.8 840.7 669.6 0.853198740347698 0.20103388513987 -0.229046259184816 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) ankyrin repeat and SAM domain-containing protein 1 -- -- CASK-interacting adaptor protein (caskin) and related proteins with ankyrin repeats and SAM domain T Signal transduction mechanisms ; IPR001660 [Sterile alpha motif domain] ; IPR006020[PTB/PI domain] ; IPR020683[Ankyrin repeat-containing domain] -- -- Q8K2C9 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 Hacd3 412.8 369.3 373.9 412.6 429.8 462.5 0.885891639206069 0.0691175828270744 -0.174797853376539 Nonsignificant None -- -- very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4.2.1.134 ko00062 Fatty acid elongation ko01040 Biosynthesis of unsaturated fatty acids ko01212 Fatty acid metabolism Protein tyrosine phosphatase-like protein PTPLA (contains Pro instead of catalytic Arg) R General function prediction only ; IPR007482 [Protein-tyrosine phosphatase-like, PTPLA] -- -- Q03141 MAP/microtubule affinity-regulating kinase 3 Mark3 575.2 583.6 359.1 347.2 337.8 380 1.42525821596244 0.112947560324973 0.511223317972715 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) MAP/microtubule affinity-regulating kinase 2.7.11.1 -- Serine/threonine protein kinase R General function prediction only ; IPR000719 [Protein kinase domain] ; IPR001772[Kinase associated domain 1 (KA1)] ; IPR015940[Ubiquitin-associated domain] -- -- Q922W5 Pyrroline-5-carboxylate reductase 1, mitochondrial Pycr1 281.9 269.3 294.5 325.2 294.4 334.4 0.886477987421384 0.0627914779250104 -0.173843287601296 Nonsignificant None -- -- pyrroline-5-carboxylate reductase 1.5.1.2 ko00330 Arginine and proline metabolism ko01100 Metabolic pathways ko01230 Biosynthesis of amino acids Pyrroline-5-carboxylate reductase E Amino acid transport and metabolism ; IPR028939 [Pyrroline-5-carboxylate reductase, catalytic, N-terminal] ; IPR029036[Pyrroline-5-carboxylate reductase, dimerisation domain] -- -- Q91VR8 Protein BRICK1 Brk1 1710.3 1688 1770.8 1698.6 1642.2 1802.3 1.00505531683226 0.878058442043744 0.00727490749709303 Nonsignificant None -- -- chromosome 3 open reading frame 10 -- ko04810 Regulation of actin cytoskeleton -- -- -- -- -- -- Q8C650 Septin-10 Septin10 323.2 295.9 343.7 349.9 366.5 376 0.881362138410839 0.0522811947644446 -0.182193172290789 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) septin 10 -- -- Septins (P-loop GTPases) D Cell cycle control, cell division, chromosome partitioning ; IPR030379 [Septin-type guanine nucleotide-binding (G) domain] -- -- A1E2H8 Ionized calcium binding adapter molecule 1 (Fragment) Aif1 638.6 724.5 924.3 914.4 992.9 890.5 0.817570948602473 0.1320317400211 -0.290584162129178 Nonsignificant None -- -- allograft inflammatory factor 1 -- -- Calmodulin and related proteins (EF-Hand superfamily) T Signal transduction mechanisms ; -- -- -- Q3TIR3 Synembryn-A Ric8a 570.6 562.8 562.7 534.9 547 585.3 1.01733445297505 0.565875282330026 0.0247940492304422 Nonsignificant None -- -- -- -- -- Signaling protein RIC-8/synembryn (regulates neurotransmitter secretion) T Signal transduction mechanisms ; IPR019318 [Guanine nucleotide exchange factor, Ric8] -- -- Q9DBL7 Bifunctional coenzyme A synthase Coasy 432.8 431.6 432.7 452.9 424.1 472.2 0.961384524162467 0.339901035085266 -0.0568145149332566 Nonsignificant None 5 Molecular Function:catalytic activity (GO:0003824),Molecular Function:dephospho-CoA kinase activity (GO:0004140),Molecular Function:ATP binding (GO:0005524),Biological Process:biosynthetic process (GO:0009058),Biological Process:coenzyme A biosynthetic process (GO:0015937) -- -- ko00770 Pantothenate and CoA biosynthesis ko01100 Metabolic pathways Predicted nucleotidyltransferase R General function prediction only ; IPR001977 [Dephospho-CoA kinase] ; IPR004821[Cytidyltransferase-like domain] -- -- Q3UVK0 Endoplasmic reticulum metallopeptidase 1 Ermp1 554.9 557.8 620.4 559.3 575.9 533.3 1.03871741084807 0.432563323564203 0.0548032139915998 Nonsignificant None -- -- -- -- -- Aminopeptidases of the M20 family OR Posttranslational modification, protein turnover, chaperones ; General function prediction only ; IPR007484 [Peptidase M28] -- -- Q8CG50 Ras-related protein Rab-43 Rab43 260 268.8 291 304.3 296.8 302 0.907762152585539 0.0429426070666679 -0.139613755780324 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-43 -- -- GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- Q6PGL7 WASH complex subunit 2 Washc2 394.4 390.2 394 371.6 389.2 369 1.04319348557267 0.0661508931553434 0.0610067655162223 Nonsignificant None -- -- WASH complex subunit FAM21 -- ko04144 Endocytosis -- -- -- IPR029341 [FAM21/CAPZIP domain] -- -- Q921V3 Cysteine desulfurase, mitochondrial Nfs1 538.3 506.5 547.9 592.3 638.1 648.6 0.847631718999468 0.0110522500236477 -0.238490519462531 Nonsignificant None -- -- cysteine desulfurase 2.8.1.7 ko00730 Thiamine metabolism ko01100 Metabolic pathways ko04122 Sulfur relay system Cysteine desulfurase NFS1 E Amino acid transport and metabolism ; IPR000192 [Aminotransferase class V domain] -- -- Q52KI7 Low density lipoprotein receptor-related protein associated protein 1 Lrpap1 1638 1619.8 1745.5 1791.4 1764.6 1624.6 0.965776164922982 0.414036374373934 -0.0502392362346706 Nonsignificant None 3 Cellular Component:endoplasmic reticulum (GO:0005783),Molecular Function:heparin binding (GO:0008201),Molecular Function:low-density lipoprotein particle receptor binding (GO:0050750) alpha-2-macroglobulin receptor-associated protein -- ko04979 Cholesterol metabolism Alpha 2-macroglobulin receptor-associated protein OUTIV Posttranslational modification, protein turnover, chaperones ; Intracellular trafficking, secretion, and vesicular transport ; Signal transduction mechanisms ; Lipid transport and metabolism ; Defense mechanisms ; IPR009066 [Alpha-2-macroglobulin receptor-associated protein, domain 1] ; IPR010483[Alpha-2-macroglobulin RAP, C-terminal] -- -- Q569U9 Retinol dehydrogenase 14 (All-trans and 9-cis) Rdh14 941.1 891.7 1087.2 1120 1016.8 1082 0.907170374052442 0.205644829789233 -0.140554568700615 Nonsignificant None -- -- retinol dehydrogenase 14 1.1.1.- -- Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Q Secondary metabolites biosynthesis, transport and catabolism ; IPR002347 [Short-chain dehydrogenase/reductase SDR] -- -- Q6ZPJ3 (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O Ube2o 592.5 573.3 597 521.2 531.2 588.6 1.07422303473492 0.141706927920188 0.103293562876361 Nonsignificant None -- -- ubiquitin-conjugating enzyme E2 O 2.3.2.24 ko04120 Ubiquitin mediated proteolysis Ubiquitin-conjugating enzyme O Posttranslational modification, protein turnover, chaperones ; IPR000608 [Ubiquitin-conjugating enzyme E2] -- -- Q9D6Y9 1,4-alpha-glucan-branching enzyme Gbe1 302.6 283.2 348.9 391.6 364.5 380.1 0.822654462242563 0.0330048332586142 -0.281641509061301 Nonsignificant None 3 Molecular Function:catalytic activity (GO:0003824),Biological Process:carbohydrate metabolic process (GO:0005975),Molecular Function:cation binding (GO:0043169) 1,4-alpha-glucan branching enzyme 2.4.1.18 ko00500 Starch and sucrose metabolism ko01100 Metabolic pathways 1,4-alpha-glucan branching enzyme/starch branching enzyme II G Carbohydrate transport and metabolism ; IPR004193 [Glycoside hydrolase, family 13, N-terminal] ; IPR006047[Glycosyl hydrolase, family 13, catalytic domain] ; IPR006048[Alpha-amylase/branching enzyme, C-terminal all beta] -- -- Q9CZ28 Vacuolar-sorting protein SNF8 Snf8 940.1 916.4 912.7 893.5 888.9 953.5 1.01217149749625 0.647774526260255 0.0174537540890165 Nonsignificant None -- -- ESCRT-II complex subunit VPS22 -- ko04144 Endocytosis RNA polymerase II transcription factor complex subunit K Transcription ; IPR007286 [EAP30] -- -- Q3URQ0 Testis-expressed protein 10 Tex10 215.7 216.8 248.1 207.4 199.8 201.1 1.11885582771659 0.0910606616100205 0.162024147093004 Nonsignificant None -- -- pre-rRNA-processing protein IPI1 -- -- Uncharacterized conserved protein S Function unknown ; IPR024679 [Pre-rRNA-processing protein IPI1/Testis-expressed sequence 10 protein] -- -- Q8CFZ6 C-type lectin domain family 3, member b Clec3b 777.9 726.9 786.3 922.6 948 925.4 0.819420600858369 0.00113961657376002 -0.287323931160431 Nonsignificant None -- -- C-type lectin domain family 3 member B -- -- C-type lectin TV Signal transduction mechanisms ; Defense mechanisms ; IPR001304 [C-type lectin-like] -- -- Q91WT9 Cystathionine beta-synthase Cbs 1216.9 1224.4 1636.4 1671.2 1778.2 1746.8 0.784746545552519 0.0586728503119349 -0.349701321797039 Nonsignificant None -- -- cystathionine beta-synthase 4.2.1.22 ko00260 Glycine, serine and threonine metabolism ko00270 Cysteine and methionine metabolism ko01100 Metabolic pathways ko01230 Biosynthesis of amino acids Cystathionine beta-synthase and related enzymes E Amino acid transport and metabolism ; IPR000644 [CBS domain] ; IPR001926[Tryptophan synthase beta subunit-like PLP-dependent enzyme] -- -- Q9ERG2 Striatin-3 Strn3 658.3 654.3 703.4 633 674.2 629.2 1.04110720925429 0.281645634291366 0.0581186395264231 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) striatin 1/3/4 -- Cell-cycle nuclear protein, contains WD-40 repeats D Cell cycle control, cell division, chromosome partitioning ; IPR001680 [WD40 repeat] ; IPR013258[Striatin, N-terminal] -- -- Q8BHZ0 CYFIP-related Rac1 interactor A Cyria 187.7 219.4 243.2 231.6 217.7 224.7 0.964836795252226 0.658382498894267 -0.0516431676289638 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR009828 [Protein of unknown function DUF1394] -- -- A0A0G2JFV5 Leucine-rich repeat flightless-interacting protein 2 Lrrfip2 559 577.7 567.1 560.9 630 626.9 0.937286830234349 0.176422364958606 -0.093437483253715 Nonsignificant None -- -- -- -- -- Double stranded RNA binding protein R General function prediction only ; IPR019139 [Leucine-rich repeat flightless-interacting protein 1/2] -- -- Q9DCZ4 MICOS complex subunit Mic26 Apoo 746.6 846.1 1148.2 1134.7 1167.5 1043.1 0.819328610289062 0.18606697462721 -0.28748590144531 Nonsignificant None 2 Biological Process:cristae formation (GO:0042407),Cellular Component:MICOS complex (GO:0061617) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019166 [MICOS complex subunit MIC26/MIC27] -- -- Q8R3I3 Conserved oligomeric Golgi complex subunit 6 Cog6 573.5 609 741.6 736.6 743.2 753.8 0.861434455587393 0.180123720855377 -0.215187065351098 Nonsignificant None -- -- conserved oligomeric Golgi complex subunit 6 -- -- Uncharacterized conserved protein S Function unknown ; -- -- -- Q91WM1 Spermatid perinuclear RNA-binding protein Strbp 941.9 968 889.1 912 940.1 926 1.00752312731723 0.790945488212719 0.010812955659374 Nonsignificant None -- -- spermatid perinuclear RNA-binding protein -- -- Transcription factor NFAT, subunit NF90 R General function prediction only ; IPR006561 [DZF domain] ; IPR014720[Double-stranded RNA-binding domain] -- -- P70340 Mothers against decapentaplegic homolog 1 Smad1 62.5 75.4 38.2 61.9 81 66.8 0.839771101573677 0.414654995441256 -0.251931952265384 Nonsignificant None 1 Cellular Component:intracellular (GO:0005622) mothers against decapentaplegic homolog 1 -- ko04350 TGF-beta signaling pathway ko04390 Hippo signaling pathway ko04550 Signaling pathways regulating pluripotency of stem cells ko05202 Transcriptional misregulation in cancer TGFbeta receptor signaling protein SMAD and related proteins TK Signal transduction mechanisms ; Transcription ; IPR001132 [SMAD domain, Dwarfin-type] ; IPR003619[MAD homology 1, Dwarfin-type] -- MH1 Q8K2F8 Protein LSM14 homolog A Lsm14a 1192 1159.5 1168.3 1232.2 1334 1251 0.922089489678298 0.0388808033743847 -0.117021322486608 Nonsignificant None -- -- protein LSM14 -- -- Uncharacterized mRNA-associated protein RAP55 U Intracellular trafficking, secretion, and vesicular transport ; IPR019050 [FDF domain] ; IPR025609[Lsm14-like, N-terminal] -- -- D3Z7P0 BRISC and BRCA1-A complex member 2 Babam2 354.2 346.2 365.7 389.1 401.5 389.1 0.903704331609731 0.00567956478411593 -0.146077257083513 Nonsignificant None -- -- BRCA1-A complex subunit BRE -- ko03440 Homologous recombination -- -- -- IPR010358 [Brain/reproductive organ-expressed protein] -- -- Q8CFE2 Histone PARylation factor 1 Hpf1 444.3 451.7 442.6 406.2 444 433.6 1.04268577660072 0.190888954271795 0.0603044533126381 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019361 [Histone PARylation factor 1] -- -- Q9Z0G0 PDZ domain-containing protein GIPC1 Gipc1 322.6 314.7 316 291.2 316.5 299.7 1.05058408640071 0.122226676075368 0.0711916367167585 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) PDZ domain-containing protein GIPC -- -- RGS-GAIP interacting protein GIPC, contains PDZ domain TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR001478 [PDZ domain] -- -- Q8R3V5 Endophilin-B2 Sh3glb2 920.1 935 830.3 867.4 934.2 802.5 1.03121999923198 0.617606898893507 0.0443521483632254 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:cytoplasm (GO:0005737) endophilin-B2 -- ko04144 Endocytosis SH3 domain protein SH3GLB T Signal transduction mechanisms ; IPR001452 [SH3 domain] ; IPR004148[BAR domain] -- -- Q8BGS1 Band 4.1-like protein 5 Epb41l5 406.8 345.3 348.4 361.3 366.2 390.8 0.984082983099347 0.800622147034078 -0.0231481184914648 Nonsignificant None -- -- -- -- -- FERM domain protein EHM2 R General function prediction only ; IPR014847 [FERM adjacent (FA)] ; IPR018979[FERM, N-terminal] ; IPR018980[FERM, C-terminal PH-like domain] ; IPR019748[FERM central domain] -- -- Q9CR41 Huntingtin-interacting protein K Hypk 581.6 554.2 523.1 494.4 526.4 544.7 1.05966145001597 0.236864372086257 0.0836034134697852 Nonsignificant None -- -- -- -- -- Huntingtin interacting protein HYPK R General function prediction only ; -- -- -- Q6ZWX2 Thymosin beta Tmsb4x 6060.7 7362 1115.5 960.7 926.1 948.6 5.12738943358962 0.176840309326441 2.35822447693783 Nonsignificant None 2 Molecular Function:actin monomer binding (GO:0003785),Biological Process:actin filament organization (GO:0007015) thymosin, beta 4 -- ko04810 Regulation of actin cytoskeleton Thymosin beta N Cell motility ; IPR001152 [Beta-thymosin] -- -- Q99104 Unconventional myosin-Va Myo5a 93.6 72.2 132.4 108.9 133.8 127 0.806599945902083 0.280618655051493 -0.310074785903801 Nonsignificant None 4 Molecular Function:motor activity (GO:0003774),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Cellular Component:myosin complex (GO:0016459) myosin V -- -- Myosin class V heavy chain Z Cytoskeleton ; IPR000048 [IQ motif, EF-hand binding site] ; IPR001609[Myosin head, motor domain] ; IPR002710[Dilute domain] -- -- Q8CCP0 Ribosome quality control complex subunit NEMF Nemf 552.2 546.6 566.8 465.5 525.7 503.6 1.11426277762911 0.0375280664956926 0.156089504918673 Nonsignificant None -- -- -- -- -- Predicted RNA-binding protein R General function prediction only ; IPR008532 [Domain of unknown function DUF814] ; IPR021846[Domain of unknown function DUF3441] -- -- Q3UKP5 Uncharacterized protein Xab2 1041.2 1013 876.5 872.5 892.8 873.7 1.11053429329291 0.194274479087709 0.151253943987753 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) pre-mRNA-splicing factor SYF1 -- ko03040 Spliceosome mRNA splicing factor A RNA processing and modification ; IPR019734 [Tetratricopeptide repeat] -- -- H3BKQ5 Gamma-glutamylaminecyclotransferase Ggact 289.1 273.6 298.4 319.7 333.6 329.5 0.876170126170126 0.00820658078598372 -0.190717069408135 Nonsignificant None -- -- gamma-glutamylaminecyclotransferase 2.3.2.- -- Uncharacterized conserved protein S Function unknown ; IPR009288 [Gamma-glutamylcyclotransferase, AIG2-like] -- -- Q8VDC1 FYVE and coiled-coil domain-containing protein 1 Fyco1 610.3 617.3 641 664.9 758.8 690.6 0.883791325734286 0.0500888069838023 -0.178222323536212 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) FYVE and coiled-coil domain-containing protein 1 -- -- FYVE finger containing protein R General function prediction only ; IPR000306 [FYVE zinc finger] ; IPR004012[RUN domain] -- -- Q99LN9 Deoxyhypusine hydroxylase Dohh 324.1 327.2 302.8 248.3 261.8 263.9 1.23268733850129 0.00272870123527013 0.301806917831041 Nonsignificant None -- -- deoxyhypusine monooxygenase 1.14.99.29 -- HEAT repeat-containing protein R General function prediction only ; -- -- -- Q3UWH6 Uncharacterized protein (Fragment) Ctsl 812.8 826.9 817.9 985.9 932.9 954.2 0.855412460842325 0.00096666871991853 -0.22530787169873 Nonsignificant None 2 Biological Process:proteolysis (GO:0006508),Molecular Function:cysteine-type peptidase activity (GO:0008234) cathepsin L 3.4.22.15 ko04140 Autophagy - animal ko04142 Lysosome ko04145 Phagosome ko04210 Apoptosis ko04612 Antigen processing and presentation ko05205 Proteoglycans in cancer ko05323 Rheumatoid arthritis ko05418 Fluid shear stress and atherosclerosis Cysteine proteinase Cathepsin L O Posttranslational modification, protein turnover, chaperones ; IPR000668 [Peptidase C1A, papain C-terminal] ; IPR013201[Cathepsin propeptide inhibitor domain (I29)] -- -- Q540H0 N-terminal amino-acid N(alpha)-acetyltransferase NatA Naa10 817.9 828.1 942.1 918.9 912.5 912.2 0.943322641784517 0.322560789618218 -0.0841767989698653 Nonsignificant None 1 Molecular Function:N-acetyltransferase activity (GO:0008080) N-alpha-acetyltransferase 10/11 2.3.1.255 -- Subunit of the major N alpha-acetyltransferase R General function prediction only ; IPR000182 [GNAT domain] -- -- Q99K28 ADP-ribosylation factor GTPase-activating protein 2 Arfgap2 1043.7 1014.6 1071.8 1047.4 1112.3 990.7 0.993556373793804 0.870079592263948 -0.00932626743717756 Nonsignificant None 1 Molecular Function:GTPase activator activity (GO:0005096) ADP-ribosylation factor GTPase-activating protein 2/3 -- ko04144 Endocytosis Predicted GTPase-activating protein T Signal transduction mechanisms ; IPR001164 [Arf GTPase activating protein] -- -- Q8BM72 Heat shock 70 kDa protein 13 Hspa13 1318.5 1329.3 1178.4 897.8 993.1 904.3 1.36884659416142 0.00393955874230953 0.452960773664052 Nonsignificant None -- -- stress 70 protein chaperone microsome-associated 60kDa protein -- -- Molecular chaperones HSP70/HSC70, HSP70 superfamily O Posttranslational modification, protein turnover, chaperones ; IPR013126 [Heat shock protein 70 family] -- -- Q8K265 WD repeat-containing protein 18 (Fragment) Wdr18 1264.5 1343.9 1352.6 1275.5 1296.3 1218.5 1.0450360129805 0.193247820688311 0.0635526598689765 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) pre-rRNA-processing protein IPI3 -- -- WD40 repeat protein R General function prediction only ; IPR001680 [WD40 repeat] ; IPR026987[WD repeat-containing protein 18, C-terminal domain] -- -- Q8C0L6 Peroxisomal N(1)-acetyl-spermine/spermidine oxidase Paox 584.6 596 611.6 639.3 604.3 650.8 0.94605152027027 0.100662027599819 -0.0800093425970029 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) N1-acetylpolyamine oxidase 1.5.3.13 ko04146 Peroxisome Flavin-containing amine oxidase H Coenzyme transport and metabolism ; IPR002937 [Amine oxidase] -- -- Q91WJ7 SPATS2-like protein Spats2l 871.2 776.9 848.2 969.6 1034.3 1046 0.818485851995147 0.00757017452745435 -0.288970615796789 Nonsignificant None -- -- -- -- -- -- -- -- IPR009816 [Protein of unknown function DUF1387] -- -- Q91VA1 Choline transporter-like protein 4 Slc44a4 1256.9 1171.8 1360.9 1326.8 1332.7 1233.2 0.973514527191923 0.616939103296731 -0.038725587280908 Nonsignificant None -- -- solute carrier family 44 (choline transporter-like protein), member 2/4/5 -- ko05231 Choline metabolism in cancer Choline transporter-like protein I Lipid transport and metabolism ; IPR007603 [Choline transporter-like] -- -- Q14BZ3 Latexin Lxn 931.7 856.2 880.3 862.6 903.8 964.9 0.976897448101637 0.601366236773488 -0.0337209747414738 Nonsignificant None -- -- -- -- -- -- -- -- IPR009684 [Proteinase inhibitor I47, latexin] -- -- Q571F3 MFLJ00061 protein (Fragment) Necap1 415.3 427.5 400.6 366.6 419.2 428.9 1.02362723306166 0.670288719505744 0.0336904351398317 Nonsignificant None 2 Biological Process:endocytosis (GO:0006897),Cellular Component:membrane (GO:0016020) adaptin ear-binding coat-associated protein 1/2 -- -- Uncharacterized conserved protein S Function unknown ; IPR012466 [NECAP, PHear domain] -- -- Q3UMU9 Hepatoma-derived growth factor-related protein 2 Hdgfl2 465.3 470.3 541 522 517.8 514.4 0.95007077596191 0.400913451066359 -0.0738931032060181 Nonsignificant None -- -- -- -- -- Transcription coactivator K Transcription ; IPR000313 [PWWP domain] ; IPR021567[Lens epithelium-derived growth factor (LEDGF)] -- -- P08553 Neurofilament medium polypeptide Nefm 229.9 237.5 315.7 305.3 305.8 306.5 0.853421970357454 0.24366267139616 -0.228668843361993 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) neurofilament medium polypeptide (neurofilament 3) -- ko05014 Amyotrophic lateral sclerosis (ALS) -- -- -- IPR001664 [Intermediate filament protein] ; IPR006821[Intermediate filament head, DNA-binding domain] -- -- Q8BHC4 Dephospho-CoA kinase domain-containing protein Dcakd 666.1 652.6 645.1 571.5 598 527.8 1.15701408118777 0.0141784902373579 0.210406422557888 Nonsignificant None 3 Molecular Function:dephospho-CoA kinase activity (GO:0004140),Molecular Function:ATP binding (GO:0005524),Biological Process:coenzyme A biosynthetic process (GO:0015937) -- -- -- Similar to bacterial dephospho-CoA kinase H Coenzyme transport and metabolism ; IPR001977 [Dephospho-CoA kinase] -- -- Q9CXI0 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial Coq5 389.9 390.4 427.8 449.6 414 406.7 0.951035188538141 0.319422377725908 -0.0724293727391929 Nonsignificant None 1 Molecular Function:methyltransferase activity (GO:0008168) 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase 2.1.1.201 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis ko01100 Metabolic pathways Ubiquinone biosynthesis methyltransferase COQ5 H Coenzyme transport and metabolism ; IPR004033 [UbiE/COQ5 methyltransferase] -- -- Q80VP1 Epsin-1 Epn1 454.8 400.8 433.3 484.4 503.8 487.4 0.873475196530225 0.0208122865534364 -0.195161358374865 Nonsignificant None -- -- epsin -- ko04144 Endocytosis Equilibrative nucleoside transporter protein F Nucleotide transport and metabolism ; IPR003903 [Ubiquitin interacting motif] ; IPR013809[ENTH domain] -- -- E9QJT5 Acylphosphatase Acyp1 776.3 784.5 807 906.7 842.2 911.1 0.89015037593985 0.0155554588728638 -0.167879019148871 Nonsignificant None -- -- acylphosphatase 3.6.1.7 ko00620 Pyruvate metabolism Acylphosphatase C Energy production and conversion ; IPR001792 [Acylphosphatase-like domain] -- -- Q99KR3 Endoribonuclease LACTB2 Lactb2 813.6 833.4 935.5 1036 989.9 976.3 0.860202518153354 0.0287933576129457 -0.217251740259021 Nonsignificant None -- -- -- -- -- Glyoxylase R General function prediction only ; IPR001279 [Metallo-beta-lactamase] -- -- A0A338P693 Protein FAM3B Fam3b 1223.6 1188.3 1461.7 1170.3 1167.7 1190.7 1.09774137784453 0.31216370980494 0.134538202931968 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- P02798 Metallothionein-2 Mt2 1203.7 1490.8 3355.8 365.1 307.1 544.2 4.97393949358764 0.138023150310063 2.31438895772933 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) metallothionein 1/2 -- ko04978 Mineral absorption Predicted metallothionein P Inorganic ion transport and metabolism ; IPR003019 [Metallothionein] -- -- Q3SXD3 5-deoxynucleotidase HDDC2 Hddc2 360.9 355.1 357.7 424.8 405 399.4 0.873494956068988 0.00277193715403072 -0.195128722455422 Nonsignificant None -- -- putative hydrolases of HD superfamily -- -- Predicted hydrolases of HD superfamily R General function prediction only ; IPR006674 [HD domain] -- -- Q91Z38 Tetratricopeptide repeat protein 1 Ttc1 1183 1129.6 981.4 911.6 941.2 902.1 1.19568768376348 0.0430408975667522 0.257840603644413 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- TPR repeat-containing protein R General function prediction only ; IPR019734 [Tetratricopeptide repeat] -- -- Q9JKX6 ADP-sugar pyrophosphatase Nudt5 733.4 758.4 722.9 753.5 744.3 771.5 0.975939717093377 0.240522101893784 -0.0351360583045331 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) -- -- ko00230 Purine metabolism Nucleoside diphosphate-sugar hydrolase of the MutT (NUDIX) family L Replication, recombination and repair ; IPR000086 [NUDIX hydrolase domain] -- -- Q8BG51 Mitochondrial Rho GTPase 1 Rhot1 331.1 345.7 341.8 323.8 336.2 328.1 1.03086732112134 0.147965956984178 0.0438586610494886 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) mitochondrial Rho GTPase 1 3.6.5.- ko04137 Mitophagy - animal Predicted Ras related/Rac-GTP binding protein V Defense mechanisms ; IPR001806 [Small GTPase superfamily] ; IPR013566[EF hand associated, type-1] ; IPR013567[EF hand associated, type-2] -- -- Q3U5K7 Cystatin domain-containing protein (Fragment) Cst3 510.6 508.2 506.9 527.3 524.4 549.3 0.952966895690194 0.083013600233859 -0.0695019964427193 Nonsignificant None 1 Molecular Function:cysteine-type endopeptidase inhibitor activity (GO:0004869) cystatin-C -- ko04970 Salivary secretion -- -- -- IPR000010 [Cystatin domain] -- -- Q9WTL2 Ras-related protein Rab-25 Rab25 459.7 439.6 383 507 467.7 505.2 0.86647746469356 0.0664082032957187 -0.206765866560915 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-25 -- -- GTPase Rab11/YPT3, small G protein superfamily U Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- Q8CFV9 Riboflavin kinase Rfk 1554.3 1388 1529.3 1401.9 1435.8 1402.5 1.05457289750483 0.219059335787905 0.0766588250829819 Nonsignificant None 2 Molecular Function:riboflavin kinase activity (GO:0008531),Biological Process:riboflavin biosynthetic process (GO:0009231) riboflavin kinase 2.7.1.26 ko00740 Riboflavin metabolism ko01100 Metabolic pathways Riboflavin kinase H Coenzyme transport and metabolism ; IPR015865 [Riboflavin kinase domain, bacterial/eukaryotic] -- -- A0A0R4J138 Arylsulfatase B Arsb 932.7 1151.9 1113.9 1130 1164 1060.3 0.953552156932892 0.522535446413654 -0.068616242358251 Nonsignificant None 2 Biological Process:metabolic process (GO:0008152),Molecular Function:sulfuric ester hydrolase activity (GO:0008484) arylsulfatase B 3.1.6.12 ko00531 Glycosaminoglycan degradation ko01100 Metabolic pathways ko04142 Lysosome Sulfatase R General function prediction only ; IPR000917 [Sulfatase, N-terminal] -- -- Q9WUD1 E3 ubiquitin-protein ligase CHIP Stub1 1431.3 1366.7 1493.3 1405.6 1414.4 1470.3 1.00023308393352 0.994017576226558 0.000336229851640549 Nonsignificant None 2 Molecular Function:ubiquitin-protein transferase activity (GO:0004842),Biological Process:protein ubiquitination (GO:0016567) STIP1 homology and U-box containing protein 1 2.3.2.27 ko04120 Ubiquitin mediated proteolysis ko04141 Protein processing in endoplasmic reticulum Chaperone-dependent E3 ubiquitin protein ligase (contains TPR repeats) O Posttranslational modification, protein turnover, chaperones ; IPR003613 [U box domain] -- -- Q9CPN8 Insulin-like growth factor 2 mRNA-binding protein 3 Igf2bp3 693.6 724.7 1026.8 598.8 593.4 557.9 1.39712016456203 0.159245612029139 0.482456110484124 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:RNA binding (GO:0003723) insulin-like growth factor 2 mRNA-binding protein 3 -- -- IGF-II mRNA-binding protein IMP, contains RRM and KH domains AR RNA processing and modification ; General function prediction only ; IPR000504 [RNA recognition motif domain] ; IPR004088[K Homology domain, type 1] -- -- D3YYJ7 Pentaxin Mptx2 31.6 26.1 29.9 206.2 196 131.7 0.164075669601049 0.0232491145064935 -2.60756677406334 Significant down -- -- -- -- -- -- -- -- IPR001759 [Pentraxin-related] -- -- Q8JZM7 Parafibromin Cdc73 910 923.6 974.8 896.5 946.5 888.2 1.02826596367897 0.39207353226583 0.0402134696420468 Nonsignificant None -- -- parafibromin -- -- RNA polymerase II assessory factor Cdc73p K Transcription ; IPR031336 [Cell division control protein 73, C-terminal] ; IPR032041[Paf1 complex subunit Cdc73, N-terminal domain] -- -- P35505 Fumarylacetoacetase Fah 259.1 233 262.9 283.3 286.7 309.6 0.858344702137335 0.0293833846879887 -0.220370959755164 Nonsignificant None 4 Molecular Function:catalytic activity (GO:0003824),Molecular Function:fumarylacetoacetase activity (GO:0004334),Biological Process:metabolic process (GO:0008152),Biological Process:aromatic amino acid family metabolic process (GO:0009072) fumarylacetoacetase 3.7.1.2 ko00350 Tyrosine metabolism ko01100 Metabolic pathways Fumarylacetoacetase G Carbohydrate transport and metabolism ; IPR011234 [Fumarylacetoacetase, C-terminal-related] ; IPR015377[Fumarylacetoacetase, N-terminal] -- -- Q9QZ06 Toll-interacting protein Tollip 649 658.1 639.4 663.3 686.3 692.9 0.952998776009792 0.037798731911339 -0.0694537336857622 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) toll-interacting protein -- ko04620 Toll-like receptor signaling pathway -- -- -- IPR000008 [C2 domain] ; IPR003892[Ubiquitin system component Cue] -- -- Q6ZPE2 Myotubularin-related protein 5 Sbf1 310.6 274.3 328.3 301 304 336.2 0.970250743731407 0.656898901297477 -0.0435704609995959 Nonsignificant None -- -- myotubularin-related protein 5/13 -- -- Predicted dual-specificity phosphatase R General function prediction only ; IPR001194 [DENN domain] ; IPR001849[Pleckstrin homology domain] ; IPR004182[GRAM domain] ; IPR005113[uDENN domain] ; IPR010569[Myotubularin-like phosphatase domain] ; IPR022096[SBF1/SBF2 domain] -- -- Q8BU88 39S ribosomal protein L22, mitochondrial Mrpl22 1003.3 1027.2 1094.1 1034.9 1089.1 1072.9 0.977384341080421 0.487725250514845 -0.0330021038965846 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L22 -- ko03010 Ribosome Mitochondrial/chloroplast ribosomal protein L22 J Translation, ribosomal structure and biogenesis ; IPR001063 [Ribosomal protein L22/L17] -- -- Q60590 Alpha-1-acid glycoprotein 1 Orm1 744.7 748.6 697.9 316.3 307.8 352.4 2.24393241167435 0.0000448310286850171 1.16602922193122 Significant up -- -- alpha-1-acid glycoprotein 1 -- -- -- -- -- IPR000566 [Lipocalin/cytosolic fatty-acid binding domain] -- -- Q9Z0H1 WD repeat-containing protein 46 Wdr46 280.2 292.3 284.9 287 278.8 250.6 1.05022048015679 0.303049212871771 0.0706922347842537 Nonsignificant None -- -- U3 small nucleolar RNA-associated protein 7 -- -- WD40-repeat-containing subunit of the 18S rRNA processing complex A RNA processing and modification ; IPR012952 [BING4, C-terminal domain] -- -- Q8BYU6 Torsin-1A-interacting protein 2 Tor1aip2 420.4 441.3 483.3 531 545.9 505.9 0.849759919130655 0.0222687551358077 -0.234872797641352 Nonsignificant None -- -- -- -- -- -- -- -- IPR008662 [Lamina-associated polypeptide 1C] -- -- B9VVT5 HNF4alpha10 (Fragment) Hnf4a 373.9 337.2 317.1 359.6 393 402.4 0.89021645021645 0.115683922802992 -0.167771934440455 Nonsignificant None 4 Cellular Component:nucleus (GO:0005634),Molecular Function:zinc ion binding (GO:0008270),Biological Process:steroid hormone mediated signaling pathway (GO:0043401),Molecular Function:sequence-specific DNA binding (GO:0043565) hepatocyte nuclear factor 4-alpha -- ko04152 AMPK signaling pathway ko04950 Maturity onset diabetes of the young Hepatocyte nuclear factor 4 and similar steroid hormone receptors K Transcription ; IPR000536 [Nuclear hormone receptor, ligand-binding domain] ; IPR001628[Zinc finger, nuclear hormone receptor-type] -- RXR-like Q9DB15 39S ribosomal protein L12, mitochondrial Mrpl12 1511.5 1493.2 1652.4 1524.4 1517.3 1548.6 1.01455242576738 0.685956380025538 0.0208434165390483 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L7/L12 -- ko03010 Ribosome Mitochondrial/chloroplast ribosomal protein L12 J Translation, ribosomal structure and biogenesis ; IPR008932 [Ribosomal protein L7/L12, oligomerisation] ; IPR013823[Ribosomal protein L7/L12, C-terminal] -- -- Q8C4J7 Transducin beta-like protein 3 Tbl3 223.8 218.9 181.1 202.9 154.9 209 1.10056457304164 0.432385191975519 0.138243794456134 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Biological Process:rRNA processing (GO:0006364),Cellular Component:small-subunit processome (GO:0032040) U3 small nucleolar RNA-associated protein 13 -- ko03008 Ribosome biogenesis in eukaryotes WD40-repeat-containing subunit of the 18S rRNA processing complex A RNA processing and modification ; IPR001680 [WD40 repeat] ; IPR013934[Small-subunit processome, Utp13] -- -- Q923L7 Ear6 protein Ear6 316.9 465 353.6 212.1 225 209.1 1.75719591457753 0.0654656170958117 0.813275050328886 Nonsignificant None -- -- -- -- -- -- -- -- IPR023412 [Ribonuclease A-domain] -- -- Q8BXN9 Transmembrane protein 87A Tmem87a 1476.6 1374.6 1443 1572.3 1589.8 1853.3 0.856202895083144 0.0659465655858066 -0.223975381152304 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) -- -- -- Predicted membrane protein S Function unknown ; IPR009637 [Lung seven transmembrane receptor-like] -- -- Q8CHC4 Synaptojanin-1 Synj1 395.1 399.9 349.8 393 361.9 368.8 1.0187772537154 0.723667217968279 0.0268386539686367 Nonsignificant None 1 Molecular Function:phosphoric ester hydrolase activity (GO:0042578) synaptojanin 3.1.3.36 ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system Inositol-1,4,5-triphosphate 5-phosphatase (synaptojanin), INP51/INP52/INP53 family U Intracellular trafficking, secretion, and vesicular transport ; IPR002013 [SAC domain] ; IPR005135[Endonuclease/exonuclease/phosphatase] ; IPR015047[Domain of unknown function DUF1866] -- -- P62488 DNA-directed RNA polymerase II subunit RPB7 Polr2g 417 408.7 448.4 455.5 467.2 463.4 0.919197749080153 0.0411554880893877 -0.121552829752419 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:DNA-directed 5'-3' RNA polymerase activity (GO:0003899) DNA-directed RNA polymerase II subunit RPB7 -- ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways ko03020 RNA polymerase ko05016 Huntington's disease ko05169 Epstein-Barr virus infection DNA-directed RNA polymerase subunit E' K Transcription ; IPR003029 [S1 domain] ; IPR005576[RNA polymerase Rpb7, N-terminal] -- -- Q3TJ07 Uncharacterized protein (Fragment) Stau1 819.9 858.6 755 738.8 770.4 767.8 1.06873078612209 0.177061371943718 0.0958984831418798 Nonsignificant None -- -- double-stranded RNA-binding protein Staufen -- -- Staufen and related double-stranded-RNA-binding proteins UK Intracellular trafficking, secretion, and vesicular transport ; Transcription ; IPR014720 [Double-stranded RNA-binding domain] ; IPR032478[Staufen, C-terminal] -- -- Q9CPX6 Ubiquitin-like-conjugating enzyme ATG3 Atg3 1409.1 1362.7 1388.6 1261.3 1274 1229.3 1.10513733198746 0.00221350915360628 0.144225659993513 Nonsignificant None -- -- ubiquitin-like-conjugating enzyme ATG3 -- ko04136 Autophagy - other ko04140 Autophagy - animal ko05167 Kaposi's sarcoma-associated herpesvirus infection Protein involved in autophagocytosis during starvation R General function prediction only ; IPR007134 [Autophagy-related protein 3, N-terminal] ; IPR007135[Autophagy-related protein 3] ; IPR019461[Autophagy-related protein 3, C-terminal] -- -- A2A6Q2 Cdc42 effector protein 4 (Fragment) Cdc42ep4 417.2 415.5 367.1 386.3 391 405 1.01480165778567 0.753710884977011 0.0211977813111141 Nonsignificant None -- -- -- -- -- -- -- -- IPR000095 [CRIB domain] -- -- Q922Q9 Chitinase domain-containing protein 1 Chid1 1143.6 1144.7 1017.4 1238.7 1069.4 1056.4 0.982523406152474 0.799844418790974 -0.0254363185208207 Nonsignificant None 1 Biological Process:carbohydrate metabolic process (GO:0005975) chitinase domain-containing protein 1 -- -- Predicted member of glycosyl hydrolase family 18 G Carbohydrate transport and metabolism ; IPR001223 [Glycoside hydrolase family 18, catalytic domain] -- -- E9QLK3 BRCA1-associated ATM activator 1 Brat1 135 138.6 129.4 124.1 106.7 120.9 1.14586295137902 0.0459422128607496 0.196434503790023 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR000357 [HEAT repeat] -- -- P97298 Pigment epithelium-derived factor Serpinf1 642.1 631.9 580.6 579 604.6 564.2 1.06110538963268 0.187058830136837 0.0855679527178751 Nonsignificant None -- -- pigment epithelium-derived factor -- ko04310 Wnt signaling pathway Serpin V Defense mechanisms ; IPR023796 [Serpin domain] -- -- Q3TAL2 Secretory carrier-associated membrane protein Scamp2 1184.4 1068.1 1274.3 1119.4 1116 1056.9 1.07122680193178 0.282773996556107 0.0992639622370904 Nonsignificant None 2 Biological Process:protein transport (GO:0015031),Cellular Component:integral component of membrane (GO:0016021) secretory carrier-associated membrane protein -- -- Secretory carrier membrane protein U Intracellular trafficking, secretion, and vesicular transport ; IPR007273 [SCAMP] -- -- Q99KY6 Cytochrome P450, family 4, subfamily f, polypeptide 13 Cyp4f13 97.1 109 111.8 129.4 131.4 116.6 0.842342342342342 0.0373795247373818 -0.247521406462469 Nonsignificant None 3 Molecular Function:iron ion binding (GO:0005506),Molecular Function:heme binding (GO:0020037),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00590 Arachidonic acid metabolism ko01100 Metabolic pathways Cytochrome P450 CYP4/CYP19/CYP26 subfamilies QI Secondary metabolites biosynthesis, transport and catabolism ; Lipid transport and metabolism ; IPR001128 [Cytochrome P450] -- -- Q9D3J1 Peptidyl-prolyl cis-trans isomerase Ppil4 409.1 461.6 359.9 375.5 377.9 375.4 1.09018426647768 0.367228062272005 0.124572004603744 Nonsignificant None 4 Biological Process:protein peptidyl-prolyl isomerization (GO:0000413),Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:peptidyl-prolyl cis-trans isomerase activity (GO:0003755),Biological Process:protein folding (GO:0006457) peptidyl-prolyl cis-trans isomerase-like 4 5.2.1.8 -- Predicted peptidyl prolyl cis-trans isomerase O Posttranslational modification, protein turnover, chaperones ; IPR000504 [RNA recognition motif domain] ; IPR002130[Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain] -- -- Q9CYW4 Haloacid dehalogenase-like hydrolase domain-containing protein 3 Hdhd3 1649 1644.2 1508.7 1584.7 1556.7 1592.1 1.01445019541565 0.654536037479477 0.0206980375040024 Nonsignificant None -- -- -- -- -- Predicted hydrolase (HAD superfamily) R General function prediction only ; IPR023214 [HAD-like domain] -- -- A2AKJ9 Syntenin-1 Sdcbp 398.8 431.2 367.3 349.1 338.2 345.3 1.15950029052876 0.0427087776060556 0.213503181471068 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) syntenin-1 -- -- -- -- -- IPR001478 [PDZ domain] -- -- P03958 Adenosine deaminase Ada 1058.7 1038.2 1101.5 943.4 1014 970.6 1.09234972677596 0.0314532397186281 0.127434823573223 Nonsignificant None 1 Molecular Function:deaminase activity (GO:0019239) adenosine deaminase 3.5.4.4 ko00230 Purine metabolism ko01100 Metabolic pathways ko05340 Primary immunodeficiency Adenine deaminase/adenosine deaminase F Nucleotide transport and metabolism ; IPR001365 [Adenosine/AMP deaminase domain] -- -- P14434 H-2 class II histocompatibility antigen, A-B alpha chain H2-Aa 327.1 412.7 469.6 579.4 677.7 484.9 0.694259471871412 0.062705944596259 -0.526453139834675 Nonsignificant None 4 Biological Process:immune response (GO:0006955),Cellular Component:membrane (GO:0016020),Biological Process:antigen processing and presentation (GO:0019882),Cellular Component:MHC class II protein complex (GO:0042613) major histocompatibility complex, class II -- ko04145 Phagosome ko04514 Cell adhesion molecules (CAMs) ko04612 Antigen processing and presentation ko04640 Hematopoietic cell lineage ko04658 Th1 and Th2 cell differentiation ko04659 Th17 cell differentiation ko04672 Intestinal immune network for IgA production ko04940 Type I diabetes mellitus ko05140 Leishmaniasis ko05145 Toxoplasmosis ko05150 Staphylococcus aureus infection ko05152 Tuberculosis ko05164 Influenza A ko05166 HTLV-I infection ko05168 Herpes simplex infection ko05310 Asthma ko05320 Autoimmune thyroid disease ko05321 Inflammatory bowel disease (IBD) ko05322 Systemic lupus erythematosus ko05323 Rheumatoid arthritis ko05330 Allograft rejection ko05332 Graft-versus-host disease ko05416 Viral myocarditis -- -- -- IPR001003 [MHC class II, alpha chain, N-terminal] ; IPR003597[Immunoglobulin C1-set] ; IPR032431[Immunoglobulin C1-set, C-terminal extension] -- -- E0CYH4 WD repeat-containing protein 26 (Fragment) Wdr26 803.9 767.7 989.7 886.6 851.4 901.1 0.970520253116593 0.731013361063368 -0.0431697750282868 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) WD40 repeat-containing protein S Function unknown ; IPR001680 [WD40 repeat] -- -- Q3TGB1 MPN domain-containing protein Stambp 435.8 378 328.3 384.7 380.7 402.7 0.977741631709614 0.798640223452109 -0.032474811607695 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) STAM-binding protein 3.4.19.12 ko04144 Endocytosis SMAD6 interacting protein AMSH, contains JAB/MPN/Mov34 domain T Signal transduction mechanisms ; IPR000555 [JAB1/MPN/MOV34 metalloenzyme domain] ; IPR015063[USP8 dimerisation domain] -- -- Q3UGC1 Uncharacterized protein Strip1 277.4 265.2 278.1 271.3 297.7 293 0.952088167053364 0.206722219976682 -0.070832916017006 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR012486 [N1221-like] ; IPR021819[Protein of unknown function DUF3402] -- -- Q8C7U7 Polypeptide N-acetylgalactosaminyltransferase 6 Galnt6 327.2 303.8 356.4 381.4 357.5 351.3 0.905705375160521 0.126023537146139 -0.142886275214175 Nonsignificant None -- -- polypeptide N-acetylgalactosaminyltransferase 2.4.1.41 ko00512 Mucin type O-glycan biosynthesis ko01100 Metabolic pathways Polypeptide N-acetylgalactosaminyltransferase O Posttranslational modification, protein turnover, chaperones ; IPR000772 [Ricin B, lectin domain] ; IPR001173[Glycosyltransferase 2-like] -- -- Q99LD9 Translation initiation factor eIF-2B subunit beta Eif2b2 792.1 799.9 668.8 636 674.4 662.2 1.14610159180777 0.094104038229561 0.196734931966699 Nonsignificant None 1 Biological Process:cellular metabolic process (GO:0044237) translation initiation factor eIF-2B subunit beta -- ko03013 RNA transport Translation initiation factor 2B, beta subunit (eIF-2Bbeta/GCD7) J Translation, ribosomal structure and biogenesis ; IPR000649 [Initiation factor 2B-related] -- -- Q80TB8 Synaptic vesicle membrane protein VAT-1 homolog-like Vat1l 468.4 479.5 639.4 558.1 552.9 544.9 0.958572377559031 0.719377411843561 -0.0610407273619195 Nonsignificant None 1 Biological Process:oxidation-reduction process (GO:0055114) -- -- -- Zinc-binding oxidoreductase CR Energy production and conversion ; General function prediction only ; IPR013154 [Alcohol dehydrogenase, N-terminal] -- -- Q9JKY0 CCR4-NOT transcription complex subunit 9 Cnot9 866.5 895.3 920.4 846.9 891.5 838.3 1.04094384289983 0.195928538975554 0.0578922398618637 Nonsignificant None -- -- CCR4-NOT transcription complex subunit 9 -- ko03018 RNA degradation Protein involved in cell differentiation/sexual development R General function prediction only ; -- -- -- Q3URG1 Uncharacterized protein Tppp 643.8 631.5 629.5 882.7 851.6 844.1 0.73875271486193 0.0000588983170508546 -0.436836567789211 Nonsignificant None -- -- -- -- -- Putative signal transduction protein p25 RT General function prediction only ; Signal transduction mechanisms ; IPR008907 [P25-alpha] -- -- Q8VBT0 Thioredoxin-related transmembrane protein 1 Tmx1 1154.8 1180.6 1238.9 1331.9 1341.9 1280.3 0.903947801016666 0.0156316168823127 -0.145688629092787 Nonsignificant None 1 Biological Process:cell redox homeostasis (GO:0045454) -- -- -- Thiol-disulfide isomerase and thioredoxin OC Posttranslational modification, protein turnover, chaperones ; Energy production and conversion ; IPR013766 [Thioredoxin domain] -- -- Q2M4J5 Matrix metalloproteinase-9 Mmp9 858.9 1210.1 846 474.8 503.8 520.1 1.94501901648095 0.0566619819824023 0.959784260532107 Nonsignificant None 4 Molecular Function:metalloendopeptidase activity (GO:0004222),Biological Process:proteolysis (GO:0006508),Molecular Function:zinc ion binding (GO:0008270),Cellular Component:extracellular matrix (GO:0031012) matrix metalloproteinase-9 (gelatinase B) 3.4.24.35 ko01522 Endocrine resistance ko04657 IL-17 signaling pathway ko04668 TNF signaling pathway ko04670 Leukocyte transendothelial migration ko04915 Estrogen signaling pathway ko04926 Relaxin signaling pathway ko05161 Hepatitis B ko05200 Pathways in cancer ko05202 Transcriptional misregulation in cancer ko05205 Proteoglycans in cancer ko05206 MicroRNAs in cancer ko05215 Prostate cancer ko05219 Bladder cancer ko05418 Fluid shear stress and atherosclerosis Gelatinase A and related matrix metalloproteases OW Posttranslational modification, protein turnover, chaperones ; Extracellular structures ; IPR000562 [Fibronectin, type II, collagen-binding] ; IPR001818[Peptidase M10, metallopeptidase] ; IPR002477[Peptidoglycan binding-like] ; IPR006970[PT repeat] ; IPR018487[Hemopexin-like repeats] -- -- Q8BH79 Anoctamin-10 Ano10 584.1 568.1 663 749.2 756.6 721.8 0.814868019393069 0.0116162661616038 -0.295361683624674 Nonsignificant None -- -- anoctamin-10 -- -- Protein required for meiotic chromosome segregation D Cell cycle control, cell division, chromosome partitioning ; IPR007632 [Anoctamin] -- -- Q3TL44 NLR family member X1 Nlrx1 626.1 568.5 524 637.4 670.5 627.9 0.887798326273375 0.0881470444708111 -0.171696106070467 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) NLR family member X1 -- ko04621 NOD-like receptor signaling pathway ko04622 RIG-I-like receptor signaling pathway ko05164 Influenza A LRR-containing protein S Function unknown ; IPR001611 [Leucine-rich repeat] -- -- Q6PGH1 Protein BUD31 homolog Bud31 601.4 619.1 604.5 644.2 673.8 658.3 0.923442797146182 0.0076352311278879 -0.114905498952554 Nonsignificant None 1 Cellular Component:nucleus (GO:0005634) -- -- -- G10 protein/predicted nuclear transcription regulator K Transcription ; IPR001748 [G10 protein] -- -- P26150 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3 Hsd3b3 858.1 874.9 1155.6 1090.1 1010.2 1026.6 0.923790335476031 0.469466217188699 -0.114362641830676 Nonsignificant None 3 Molecular Function:3-beta-hydroxy-delta5-steroid dehydrogenase activity (GO:0003854),Biological Process:steroid biosynthetic process (GO:0006694),Biological Process:oxidation-reduction process (GO:0055114) -- -- -- C-3 sterol dehydrogenase/3-beta-hydroxysteroid dehydrogenase and related dehydrogenases IE Lipid transport and metabolism ; Amino acid transport and metabolism ; IPR002225 [3-beta hydroxysteroid dehydrogenase/isomerase] -- -- Q8R1T4 UDP-N-acetylglucosamine transporter Slc35a3 667.8 734.6 724 875.8 798.9 890.4 0.828973529297103 0.0141342698711366 -0.270602060429928 Nonsignificant None 4 Cellular Component:Golgi membrane (GO:0000139),Molecular Function:sugar:proton symporter activity (GO:0005351),Biological Process:carbohydrate transport (GO:0008643),Cellular Component:integral component of membrane (GO:0016021) solute carrier family 35 (UDP-sugar transporter), member A1/2/3 -- -- Predicted UDP-galactose transporter G Carbohydrate transport and metabolism ; IPR007271 [Nucleotide-sugar transporter] -- -- A0A571BFA7 Protein FAM83H Fam83h 1228.5 1312.6 1306.2 1265.1 1311.4 1228.2 1.01119667779326 0.714813384631233 0.0160636287749358 Nonsignificant None -- -- -- -- -- -- -- -- IPR012461 [Protein of unknown function DUF1669] -- -- Q571M0 MKIAA4032 protein (Fragment) Mfn1 545.2 559.6 450.9 412.5 416 404.7 1.26151475835225 0.0861662678331396 0.33515708437768 Nonsignificant None 4 Molecular Function:GTPase activity (GO:0003924),Cellular Component:mitochondrial outer membrane (GO:0005741),Biological Process:mitochondrial fusion (GO:0008053),Cellular Component:integral component of membrane (GO:0016021) mitofusin 1 3.6.5.- ko04137 Mitophagy - animal ko04621 NOD-like receptor signaling pathway Mitofusin 1 GTPase, involved in mitochondrila biogenesis O Posttranslational modification, protein turnover, chaperones ; IPR006884 [Fzo/mitofusin HR2 domain] ; IPR022812[Dynamin superfamily] -- -- A2CG35 Ras-related protein Rab-12 Rab12 488 477.8 486.6 463.8 419.5 448.4 1.09063602913569 0.0395928790033265 0.125169720753958 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-12 -- -- GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- A0A087WNV1 Arf-GAP domain and FG repeat-containing protein 1 Agfg1 1144.1 1118.7 1026.5 1019.3 1080.5 1022.4 1.05351995387868 0.244868575436029 0.075217639346667 Nonsignificant None 1 Molecular Function:GTPase activator activity (GO:0005096) Arf-GAP domain and FG repeats-containing protein 1 -- ko05164 Influenza A Predicted GTPase-activating protein T Signal transduction mechanisms ; IPR001164 [Arf GTPase activating protein] -- -- Q3UMF0 Cordon-bleu protein-like 1 Cobll1 544.1 545.1 528.6 603.1 609.2 571.8 0.906787736113446 0.0122004959092309 -0.141163215462785 Nonsignificant None -- -- -- -- -- -- -- -- IPR019025 [Cordon-bleu, ubiquitin-like domain] -- -- P09528 Ferritin heavy chain Fth1 746.6 775.8 746.8 781.1 782.9 930.7 0.909608369743857 0.210928930989012 -0.136682565665555 Nonsignificant None 2 Biological Process:cellular iron ion homeostasis (GO:0006879),Molecular Function:ferric iron binding (GO:0008199) ferritin heavy chain 1.16.3.2 ko04216 Ferroptosis ko04217 Necroptosis ko04978 Mineral absorption Ferritin P Inorganic ion transport and metabolism ; IPR008331 [Ferritin/DPS protein domain] -- -- Q3TMX7 Sulfhydryl oxidase 2 Qsox2 874.3 859.2 592.4 548.5 567.8 595.2 1.3589833479404 0.152037528935107 0.442527778407742 Nonsignificant None 3 Molecular Function:thiol oxidase activity (GO:0016972),Biological Process:cell redox homeostasis (GO:0045454),Biological Process:oxidation-reduction process (GO:0055114) thiol oxidase 1.8.3.2 -- FAD-dependent sulfhydryl oxidase/quiescin and related proteins D Cell cycle control, cell division, chromosome partitioning ; IPR013766 [Thioredoxin domain] ; IPR017905[ERV/ALR sulfhydryl oxidase domain] -- -- Q8QZY9 Splicing factor 3B subunit 4 Sf3b4 715.7 760.5 548.7 520 568 535.2 1.24747412518482 0.112298374713767 0.319009891831329 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) splicing factor 3B subunit 4 -- ko03040 Spliceosome Splicing factor 3b, subunit 4 A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- A0A1W2P7T7 Lipid droplet-associated hydrolase (Fragment) Ldah 276.3 261.8 311 240.8 260.9 248.5 1.13183151159691 0.104099521520222 0.178659209516645 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; -- -- -- Q8BJA6 Protein kinase domain-containing protein (Fragment) Camk1 780.2 807.1 805.9 807.2 824 809.8 0.980417861532159 0.193625895561776 -0.0285313270135605 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) calcium/calmodulin-dependent protein kinase I 2.7.11.17 ko04921 Oxytocin signaling pathway ko04925 Aldosterone synthesis and secretion Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q9CWU2 Palmitoyltransferase ZDHHC13 Zdhhc13 927.7 860.4 943.2 810.7 836.1 797.7 1.11732460625895 0.0263303275892649 0.160048379918638 Nonsignificant None -- -- palmitoyltransferase ZDHHC13/17 2.3.1.225 -- Ankyrin repeat and DHHC-type Zn-finger domain containing proteins R General function prediction only ; IPR001594 [Palmitoyltransferase, DHHC domain] ; IPR020683[Ankyrin repeat-containing domain] -- -- Q91X51 Golgi reassembly-stacking protein 1 Gorasp1 186.7 190.1 181.1 202.9 203.9 205.6 0.911005878510777 0.00268337069222945 -0.134467731451712 Nonsignificant None -- -- -- -- -- Golgi reassembly stacking protein GRASP65, contains PDZ domain U Intracellular trafficking, secretion, and vesicular transport ; IPR024958 [GRASP55/65 PDZ-like domain] -- -- Q3THK3 General transcription factor IIF subunit 1 Gtf2f1 717.5 741.6 677.3 632.6 638.1 607.8 1.13729039126963 0.0147941807808623 0.185600673363001 Nonsignificant None 4 Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634),Biological Process:transcription initiation from RNA polymerase II promoter (GO:0006367),Biological Process:positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968) transcription initiation factor TFIIF subunit alpha -- ko03022 Basal transcription factors Transcription initiation factor IIF, large subunit (RAP74) K Transcription ; IPR008851 [Transcription initiation factor IIF, alpha subunit] -- -- A0A494BBA8 40S ribosomal protein S30 Fau 3721.3 3775.4 3336.9 2703.3 2669.3 2752.2 1.33339897597479 0.0029840380371787 0.415108524265487 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S30e -- ko03010 Ribosome Ubiquitin-like/40S ribosomal S30 protein fusion JO Translation, ribosomal structure and biogenesis ; Posttranslational modification, protein turnover, chaperones ; IPR006846 [Ribosomal protein S30] -- -- Q99KN2 Probable cytosolic iron-sulfur protein assembly protein CIAO1 Ciao1 433.3 485.8 483.3 501.3 495.3 473.5 0.953948710972043 0.302210288016662 -0.0680163930333099 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- WD40 repeat protein R General function prediction only ; IPR001680 [WD40 repeat] -- -- A2AWA9 Rab GTPase-activating protein 1 Rabgap1 603.3 580.8 638 646.8 603.9 650.4 0.95844511072537 0.30416320351679 -0.0612322824532895 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) Rab GTPase-activating protein 1 -- -- Rab6 GTPase activator GAPCenA and related TBC domain proteins R General function prediction only ; IPR000195 [Rab-GTPase-TBC domain] ; IPR006020[PTB/PI domain] ; IPR022164[Kinesin-like] -- -- P02802 Metallothionein-1 Mt1 617.9 750 2447 417.8 374.6 487.8 2.97992501171692 0.287659955302 1.57527602646417 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) metallothionein 1/2 -- ko04978 Mineral absorption Predicted metallothionein P Inorganic ion transport and metabolism ; IPR003019 [Metallothionein] -- -- Q8BLY2 Threonine--tRNA ligase 2, cytoplasmic Tars3 38.6 43.6 47.3 53.1 43.6 51.7 0.872641509433962 0.180532886526626 -0.196538994046887 Nonsignificant None 5 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation for protein translation (GO:0006418),Biological Process:tRNA aminoacylation (GO:0043039) threonyl-tRNA synthetase 6.1.1.3 ko00970 Aminoacyl-tRNA biosynthesis Threonyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR002314 [Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)] ; IPR004095[TGS] ; IPR004154[Anticodon-binding] ; IPR012947[Threonyl/alanyl tRNA synthetase, SAD] -- -- Q07456 Protein AMBP Ambp 1266.7 1469.6 1176.5 657.2 662.8 619.7 2.01721915760169 0.015155638511288 1.01236783179877 Significant up 1 Molecular Function:serine-type endopeptidase inhibitor activity (GO:0004867) -- -- -- -- -- -- IPR000566 [Lipocalin/cytosolic fatty-acid binding domain] ; IPR002223[Pancreatic trypsin inhibitor Kunitz domain] -- -- Q99KG3 RNA-binding protein 10 Rbm10 515.6 517.9 557.5 591.4 599.7 602.9 0.886845039018952 0.00849310464647254 -0.173246054588213 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:zinc ion binding (GO:0008270) RNA-binding protein 5/10 -- -- RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains R General function prediction only ; IPR000467 [G-patch domain] ; IPR000504[RNA recognition motif domain] ; IPR001876[Zinc finger, RanBP2-type] -- -- Q921L5 Conserved oligomeric Golgi complex subunit 2 Cog2 275.7 257.3 256.3 279.2 298.6 304.3 0.894796508332389 0.0350857357429009 -0.160368468152127 Nonsignificant None -- -- conserved oligomeric Golgi complex subunit 2 -- -- Low density lipoprotein receptor U Intracellular trafficking, secretion, and vesicular transport ; IPR024602 [Conserved oligomeric Golgi complex, subunit 2, N-terminal] ; IPR024603[COG complex component, COG2, C-terminal] -- -- Q68FF6 ARF GTPase-activating protein GIT1 Git1 538.2 535.8 677.8 752.2 702.3 691.6 0.816271375984344 0.059935621273832 -0.2928792273734 Nonsignificant None 1 Molecular Function:GTPase activator activity (GO:0005096) G protein-coupled receptor kinase interactor 1 -- ko04144 Endocytosis ko04810 Regulation of actin cytoskeleton GTPase-activating proteins of the GIT family T Signal transduction mechanisms ; IPR001164 [Arf GTPase activating protein] ; IPR013724[GIT, Spa2 homology (SHD) domain] ; IPR020683[Ankyrin repeat-containing domain] ; IPR022018[ARF GTPase-activating protein GIT1, C-terminal] ; IPR032352[Arf GTPase-activating protein GIT1/2, coiled-coil domain] -- -- Q8CEC8 Eukaryotic elongation factor 2 kinase Eef2k 372.3 377.2 404.7 429.8 501.4 487.9 0.8133323937707 0.0217051754313286 -0.29808301953521 Nonsignificant None 3 Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) elongation factor 2 kinase 2.7.11.20 ko04152 AMPK signaling pathway ko04921 Oxytocin signaling pathway -- -- -- IPR004166 [MHCK/EF2 kinase] ; IPR006597[Sel1-like repeat] -- -- Q6P9Q4 FH1/FH2 domain-containing protein 1 Fhod1 365.5 345.1 353.3 339.7 343.7 367.4 1.01246669204416 0.698329982246757 0.0178744472435522 Nonsignificant None -- -- -- -- -- Rac1 GTPase effector FHOS TZ Signal transduction mechanisms ; Cytoskeleton ; IPR015425 [Formin, FH2 domain] -- -- D3Z3V3 Septin-1 Septin1 362.9 319.1 281.1 276 332.5 305.8 1.05337416602866 0.6013945107473 0.0750179829836889 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) septin 1 -- ko05100 Bacterial invasion of epithelial cells Septin family protein (P-loop GTPase) DZU Cell cycle control, cell division, chromosome partitioning ; Cytoskeleton ; Intracellular trafficking, secretion, and vesicular transport ; IPR030379 [Septin-type guanine nucleotide-binding (G) domain] -- -- Q6W8Q3 Purkinje cell protein 4-like protein 1 Pcp4l1 880.7 1024.4 934.2 1033.9 1042 873.2 0.96276830219389 0.624543106673367 -0.054739451018946 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- O88736 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 Hsd17b7 452.2 443.3 529.2 523.1 552.2 531.3 0.886779534420515 0.101456690889269 -0.173352619597267 Nonsignificant None -- -- -- -- ko00100 Steroid biosynthesis ko00140 Steroid hormone biosynthesis ko01100 Metabolic pathways ko04913 Ovarian steroidogenesis 3-keto sterol reductase I Lipid transport and metabolism ; IPR002347 [Short-chain dehydrogenase/reductase SDR] -- -- Q9JK92 Heat shock protein beta-8 Hspb8 778.8 774.2 623.1 792.5 773.9 820.5 0.911684611839625 0.254899459611957 -0.133393270090269 Nonsignificant None -- -- heat shock protein beta-8 -- -- Alpha crystallins O Posttranslational modification, protein turnover, chaperones ; IPR002068 [Alpha crystallin/Hsp20 domain] -- -- Q8C2E7 WASH complex subunit 5 Washc5 596.2 595.8 454.2 492.3 512.3 474.4 1.1130493576741 0.314692133554093 0.154517569762345 Nonsignificant None 1 Cellular Component:WASH complex (GO:0071203) WASH complex subunit strumpellin -- ko04144 Endocytosis Uncharacterized conserved protein S Function unknown ; IPR019393 [WASH complex, subunit strumpellin] -- -- Q3UP87 Neutrophil elastase Elane 894.7 1537 928.4 433.5 445.8 417.5 2.59107032695867 0.0808254963213778 1.37354817374941 Nonsignificant None 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) leukocyte elastase 3.4.21.37 ko05202 Transcriptional misregulation in cancer ko05322 Systemic lupus erythematosus Trypsin E Amino acid transport and metabolism ; IPR001254 [Serine proteases, trypsin domain] -- -- Q3UZV6 N-acetylated alpha-linked acidic dipeptidase 2 Naalad2 282 282.7 313.5 291.4 306 355.1 0.921994750656168 0.321064799170719 -0.117169558141505 Nonsignificant None -- -- N-acetylated-alpha-linked acidic dipeptidase 3.4.17.21 -- Transferrin receptor and related proteins containing the protease-associated (PA) domain OPR Posttranslational modification, protein turnover, chaperones ; Inorganic ion transport and metabolism ; General function prediction only ; IPR003137 [PA domain] ; IPR007365[Transferrin receptor-like, dimerisation domain] ; IPR007484[Peptidase M28] -- -- Q9Z120 tRNA (guanine-N(7)-)-methyltransferase Mettl1 360.8 390.7 345.1 371.2 311.9 299.6 1.11590515925511 0.2156155490573 0.158214417770517 Nonsignificant None 2 Biological Process:tRNA modification (GO:0006400),Molecular Function:tRNA (guanine-N7-)-methyltransferase activity (GO:0008176) tRNA (guanine-N7-)-methyltransferase 2.1.1.33 -- Methyltransferase-like protein R General function prediction only ; IPR003358 [tRNA (guanine-N-7) methyltransferase, Trmb type] -- -- A0A338P7B7 Dynein light chain Tctex-type 1A Dynlt1a 635.4 621.5 636.6 588 617.3 594 1.05235369310287 0.0366131987932033 0.0736196718598113 Nonsignificant None -- -- dynein light chain Tctex-type 1 -- -- Dynein light chain N Cell motility ; IPR005334 [Tctex-1] -- -- Q6P8N8 ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial Clpx 876.7 854.4 956.1 1002.2 1030.8 967.1 0.895703476550782 0.0440321961666478 -0.158906889069324 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) ATP-dependent Clp protease ATP-binding subunit ClpX -- Putative ATP-dependent Clp-type protease (AAA+ ATPase superfamily) O Posttranslational modification, protein turnover, chaperones ; IPR003959 [ATPase, AAA-type, core] ; IPR019489[Clp ATPase, C-terminal] -- -- Q8R4D4 Signal transducer and activator of transcription Stat6 676.8 733.5 750.1 672 682.3 680.7 1.06162162162162 0.198187913473485 0.0862696589110186 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Biological Process:signal transduction (GO:0007165) signal transducer and activator of transcription 6 -- ko04217 Necroptosis ko04630 Jak-STAT signaling pathway ko04658 Th1 and Th2 cell differentiation ko04659 Th17 cell differentiation ko05161 Hepatitis B ko05200 Pathways in cancer ko05321 Inflammatory bowel disease (IBD) STAT protein KT Transcription ; Signal transduction mechanisms ; IPR000980 [SH2 domain] ; IPR013799[STAT transcription factor, protein interaction] ; IPR013800[STAT transcription factor, all-alpha domain] ; IPR013801[STAT transcription factor, DNA-binding] ; IPR028187[STAT6, C-terminal] -- STAT O08715 A-kinase anchor protein 1, mitochondrial Akap1 743.9 687.3 870.4 682 703.8 673.7 1.11755280407866 0.215276948558821 0.160342999983668 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) A-kinase anchor protein 1, mitochondrial -- -- Kinase anchor protein AKAP149, contains KH and Tudor RNA-binding domains T Signal transduction mechanisms ; IPR002999 [Tudor domain] ; IPR004088[K Homology domain, type 1] -- -- K3W4S6 Glycogenin Gyg 1090 1101 1120.7 997.5 976.1 978.1 1.12196361418843 0.000441935794034009 0.166025889421668 Nonsignificant None -- -- glycogenin 2.4.1.186 ko00500 Starch and sucrose metabolism ko01100 Metabolic pathways Glycosyl transferase, family 8 - glycogenin G Carbohydrate transport and metabolism ; IPR002495 [Glycosyl transferase, family 8] -- -- Q9R0Q9 Mannose-P-dolichol utilization defect 1 protein Mpdu1 638.3 631.4 959.7 819.2 846.6 864.6 0.881046474865634 0.452437980361955 -0.182709972121085 Nonsignificant None -- -- mannose-P-dolichol utilization defect 1 -- -- Predicted endoplasmic reticulum membrane protein Lec35/MPDU1 involved in monosaccharide-P-dolichol utilization R General function prediction only ; IPR006603 [PQ-loop repeat] -- -- Q3TJI7 Tyrosine-protein kinase Yes1 329.6 321.7 374.8 366.1 361.2 379.3 0.927254653894813 0.197941481292967 -0.108962491248731 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein binding (GO:0005515),Biological Process:protein phosphorylation (GO:0006468) tyrosine-protein kinase Yes 2.7.10.2 ko04520 Adherens junction Tyrosine kinases T Signal transduction mechanisms ; IPR000980 [SH2 domain] ; IPR001245[Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR001452[SH3 domain] -- -- P34884 Macrophage migration inhibitory factor Mif 1724.2 1875.8 1754.9 1643.9 1781.3 1623.5 1.06064927605126 0.206663002515599 0.0849476804283626 Nonsignificant None -- -- phenylpyruvate tautomerase 5.3.2.1 ko00350 Tyrosine metabolism ko00360 Phenylalanine metabolism Macrophage migration inhibitory factor V Defense mechanisms ; IPR001398 [Macrophage migration inhibitory factor] -- -- O88796 Ribonuclease P protein subunit p30 Rpp30 504 482.8 418.7 454.9 464.8 496.4 0.992514652919992 0.907416781432531 -0.0108396933481815 Nonsignificant None 2 Molecular Function:ribonuclease activity (GO:0004540),Biological Process:tRNA processing (GO:0008033) ribonuclease P/MRP protein subunit RPP1 3.1.26.5 ko03008 Ribosome biogenesis in eukaryotes ko03013 RNA transport Protein subunit of nuclear ribonuclease P (RNase P) J Translation, ribosomal structure and biogenesis ; IPR002738 [RNase P subunit p30] -- -- E9Q3E2 Synaptopodin Synpo 329.5 339.2 387.4 382.4 416.6 391.5 0.887106257874842 0.0955096837685184 -0.172821173531599 Nonsignificant None -- -- synaptopodin -- ko04530 Tight junction -- -- -- -- -- -- Q5SFM8 RNA-binding protein 27 Rbm27 329.8 299.8 302.2 299 318.1 332.9 0.980842105263158 0.681749488356063 -0.0279071829972151 Nonsignificant None 2 Biological Process:mRNA processing (GO:0006397),Molecular Function:metal ion binding (GO:0046872) RNA-binding protein 27 -- -- Proteins containing the RNA recognition motif R General function prediction only ; IPR000571 [Zinc finger, CCCH-type] ; IPR002483[PWI domain] -- -- Q9D8S4 Oligoribonuclease, mitochondrial Rexo2 1943.4 1851.9 1806.2 1889.7 1901.3 1844.8 0.993913907519784 0.80721304808948 -0.00880720343522862 Nonsignificant None -- -- oligoribonuclease 3.1.-.- ko03008 Ribosome biogenesis in eukaryotes Oligoribonuclease (3'->5' exoribonuclease) A RNA processing and modification ; IPR013520 [Exonuclease, RNase T/DNA polymerase III] -- -- Q64332 Synapsin-2 Syn2 873.5 846.4 716 894.5 855.1 930.7 0.908816177293587 0.201078793679674 -0.137939579264056 Nonsignificant None -- -- synapsin -- -- Synaptic vesicle protein Synapsin TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR019736 [Synapsin, phosphorylation site] ; IPR020897[Synapsin, pre-ATP-grasp domain] ; IPR020898[Synapsin, ATP-binding domain] -- -- A0A0R4J1N9 Transcription factor A, mitochondrial Tfam 996.2 1045.1 1352.9 1369.3 1297.6 1287.7 0.8582916097709 0.178335401193225 -0.220460199500658 Nonsignificant None -- -- transcription factor A, mitochondrial -- ko04371 Apelin signaling pathway ko05016 Huntington's disease HMG box-containing protein R General function prediction only ; IPR009071 [High mobility group box domain] -- HMG Q91V81 RNA-binding protein 42 Rbm42 828.5 796.7 760.8 654.9 724.8 709.6 1.1420092854066 0.0266122443126663 0.19157438095959 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- RNA-binding proteins R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- G5E8M7 Glutathione transferase Gstm6 50.8 49.3 56 92.4 96.8 94.1 0.551006000705965 0.0000603454173404955 -0.85986006440019 Significant down 1 Molecular Function:protein binding (GO:0005515) glutathione S-transferase 2.5.1.18 ko00480 Glutathione metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko01524 Platinum drug resistance ko05200 Pathways in cancer ko05204 Chemical carcinogenesis ko05225 Hepatocellular carcinoma ko05418 Fluid shear stress and atherosclerosis Glutathione S-transferase O Posttranslational modification, protein turnover, chaperones ; IPR004045 [Glutathione S-transferase, N-terminal] ; IPR004046[Glutathione S-transferase, C-terminal] -- -- A0A338P673 Chloride channel protein 2 Clcn2 546.8 524.8 563 651.5 653.4 607.3 0.854826900951783 0.00775690741268448 -0.226295785323116 Nonsignificant None 4 Molecular Function:voltage-gated chloride channel activity (GO:0005247),Biological Process:chloride transport (GO:0006821),Cellular Component:membrane (GO:0016020),Biological Process:transmembrane transport (GO:0055085) chloride channel 2 -- ko04978 Mineral absorption Cl- channel CLC-2 and related proteins (CLC superfamily) P Inorganic ion transport and metabolism ; IPR001807 [Chloride channel, voltage gated] -- -- B3DFI8 Cisd3 protein (Fragment) Cisd3 883.8 871.9 1000.9 1393.3 1345.4 1397.8 0.6664087997099 0.000491986756216901 -0.585520643742703 Significant down 1 Cellular Component:intracellular membrane-bounded organelle (GO:0043231) -- -- -- Uncharacterized conserved protein containing CDGSH-type Zn-finger S Function unknown ; IPR018967 [Iron sulphur-containing domain, CDGSH-type] -- -- Q8R3X6 Glypican-6 Gpc6 85 79.5 63.2 65.9 55.6 67.9 1.20221752903907 0.167151977674084 0.265697960668237 Nonsignificant None 3 Cellular Component:proteinaceous extracellular matrix (GO:0005578),Cellular Component:membrane (GO:0016020),Molecular Function:heparan sulfate proteoglycan binding (GO:0043395) glypican 6 -- -- Heparin sulfate cell surface proteoglycan T Signal transduction mechanisms ; IPR001863 [Glypican] -- -- Q3U962 Collagen alpha-2(V) chain Col5a2 934.9 876.8 1067.4 1584.5 1557.2 1329.3 0.643949899351376 0.00576665624717044 -0.634979646872018 Significant down 2 Molecular Function:extracellular matrix structural constituent (GO:0005201),Molecular Function:protein binding (GO:0005515) collagen, type V/XI/XXIV/XXVII, alpha -- ko04974 Protein digestion and absorption Collagens (type IV and type XIII), and related proteins W Extracellular structures ; IPR000885 [Fibrillar collagen, C-terminal] ; IPR001007[VWFC domain] ; IPR008160[Collagen triple helix repeat] -- -- P70412 CUB and zona pellucida-like domain-containing protein 1 Cuzd1 481.6 444.5 632.8 426.4 480.4 415.3 1.17910899326829 0.265307743226656 0.237697082846801 Nonsignificant None -- -- -- -- -- -- -- -- IPR000859 [CUB domain] ; IPR001507[Zona pellucida domain] -- -- A0A140T8T7 Collagen alpha-5(VI) chain Col6a5 321.5 286.5 381.1 437.4 443.1 414.3 0.763901760889713 0.0245458719914813 -0.38854097781763 Nonsignificant None -- -- collagen, type VI, alpha -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04974 Protein digestion and absorption ko05165 Human papillomavirus infection Collagens (type IV and type XIII), and related proteins W Extracellular structures ; IPR002035 [von Willebrand factor, type A] ; IPR008160[Collagen triple helix repeat] -- -- Q8BP71 RNA binding protein fox-1 homolog 2 Rbfox2 126.3 137.8 151.4 144.7 143 139.9 0.971702525724977 0.614181327152864 -0.0414133760627837 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) RNA binding protein fox-1 -- -- Ataxin 2-binding protein (RRM superfamily) R General function prediction only ; IPR000504 [RNA recognition motif domain] ; IPR025670[Fox-1 C-terminal domain] -- -- Q8R2R0 Exosome component 10 Exosc10 745.9 721.2 727 664.1 676.8 700.2 1.07495958061829 0.016932578648002 0.104282414291168 Nonsignificant None 6 Cellular Component:nuclear exosome (RNase complex) (GO:0000176),Molecular Function:nucleic acid binding (GO:0003676),Cellular Component:intracellular (GO:0005622),Biological Process:nucleobase-containing compound metabolic process (GO:0006139),Biological Process:RNA processing (GO:0006396),Molecular Function:3'-5' exonuclease activity (GO:0008408) exosome complex exonuclease RRP6 3.1.13.- ko03018 RNA degradation Exosome 3'-5' exoribonuclease complex, subunit PM/SCL-100 (Rrp6) J Translation, ribosomal structure and biogenesis ; IPR002121 [HRDC domain] ; IPR002562[3'-5' exonuclease domain] ; IPR012588[Exosome-associated factor Rrp6, N-terminal] -- -- F8WHU7 Cohesin subunit SA-1 Stag1 586.8 605.7 675.9 638.9 643.1 668.2 0.958055584042662 0.394486115210844 -0.0618187348586641 Nonsignificant None -- -- cohesin complex subunit SA-1/2 -- ko04110 Cell cycle Sister chromatid cohesion complex Cohesin, subunit STAG/IRR1/SCC3 D Cell cycle control, cell division, chromosome partitioning ; IPR013721 [STAG] -- -- Q9D4H1 Exocyst complex component 2 Exoc2 561.9 533.1 361.3 379.8 405 429.4 1.19939054521496 0.27738131520669 0.262301505208932 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) exocyst complex component 2 -- ko04014 Ras signaling pathway Sec5 subunit of exocyst complex U Intracellular trafficking, secretion, and vesicular transport ; IPR002909 [IPT domain] -- -- O88983 Syntaxin-8 Stx8 492 457.4 518.7 496.2 500.3 483.5 0.99195945945946 0.840298225425281 -0.0116469347912869 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) syntaxin 8 -- ko04130 SNARE interactions in vesicular transport SNARE protein TLG1/Syntaxin 6 U Intracellular trafficking, secretion, and vesicular transport ; IPR000727 [Target SNARE coiled-coil homology domain] -- -- Q3U3H9 Uncharacterized protein Dcaf7 450.8 407 503.1 474 488.5 522.4 0.916492693110647 0.256644412157254 -0.125804716200822 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) WD repeat-containing protein 68 -- -- Conserved WD40 repeat-containing protein AN11 S Function unknown ; IPR001680 [WD40 repeat] -- -- Q8BHB4 WD repeat-containing protein 3 Wdr3 577.7 526 460.2 440.6 433.3 456.6 1.17542277339346 0.0883540763825243 0.233179755407586 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) U3 small nucleolar RNA-associated protein 12 -- ko03008 Ribosome biogenesis in eukaryotes WD40-repeat-containing subunit of the 18S rRNA processing complex A RNA processing and modification ; IPR001680 [WD40 repeat] ; IPR007148[Small-subunit processome, Utp12] -- -- A6H6A9 Rab GTPase-activating protein 1-like Rabgap1l 508.5 517.4 534.7 642.3 698.7 612.3 0.798955613577023 0.00778657611606942 -0.323812739232305 Nonsignificant None -- -- Rab GTPase-activating protein 1 -- -- Rab6 GTPase activator GAPCenA and related TBC domain proteins R General function prediction only ; IPR000195 [Rab-GTPase-TBC domain] ; IPR022164[Kinesin-like] -- -- Q9QVP9 Protein-tyrosine kinase 2-beta Ptk2b 802 834.2 738.8 729.6 802.4 702.8 1.06273492035081 0.316659233166713 0.0877817880390064 Nonsignificant None 6 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein tyrosine kinase activity (GO:0004713),Molecular Function:signal transducer activity (GO:0004871),Cellular Component:focal adhesion (GO:0005925),Biological Process:protein phosphorylation (GO:0006468),Biological Process:signal complex assembly (GO:0007172) focal adhesion kinase 2 2.7.10.2 ko04020 Calcium signaling pathway ko04062 Chemokine signaling pathway ko04072 Phospholipase D signaling pathway ko04650 Natural killer cell mediated cytotoxicity ko04670 Leukocyte transendothelial migration ko04912 GnRH signaling pathway ko05161 Hepatitis B Focal adhesion tyrosine kinase FAK, contains FERM domain T Signal transduction mechanisms ; IPR001245 [Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR005189[Focal adhesion kinase, targeting (FAT) domain] ; IPR019748[FERM central domain] -- -- A2BDX3 Adenylyltransferase and sulfurtransferase MOCS3 Mocs3 226.9 219.8 230.8 206.6 216 203.5 1.08209551189906 0.0257687567083487 0.113827845247605 Nonsignificant None 1 Molecular Function:small protein activating enzyme activity (GO:0008641) -- -- ko04122 Sulfur relay system Molybdopterin synthase sulfurylase H Coenzyme transport and metabolism ; IPR000594 [THIF-type NAD/FAD binding fold] ; IPR001763[Rhodanese-like domain] -- -- A2AS03 Helicase with zinc finger domain 2 Helz2 503.3 490.8 451.1 461.8 487.6 505.3 0.993469443871589 0.882894682839314 -0.00945249968504271 Nonsignificant None -- -- -- -- -- Exosomal 3'-5' exoribonuclease complex, subunit Rrp44/Dis3 J Translation, ribosomal structure and biogenesis ; -- -- -- Q91WS2 NACHT, LRR and PYD domains-containing protein 6 Nlrp6 279.5 276.7 307.2 280.1 327.5 308 0.942988204456094 0.360123252067016 -0.0846883700942325 Nonsignificant None -- -- NACHT, LRR and PYD domains-containing protein 6 -- ko04621 NOD-like receptor signaling pathway -- -- -- IPR004020 [DAPIN domain] -- -- Q8C9B9 Death-inducer obliterator 1 Dido1 547.7 562.5 525.6 543.6 538.8 547.1 1.00386621663087 0.857741856471167 0.00556701683492444 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Uncharacterized PHD Zn-finger protein R General function prediction only ; IPR003618 [Transcription elongation factor S-II, central domain] ; IPR012921[Spen paralogue and orthologue SPOC, C-terminal] ; IPR019787[Zinc finger, PHD-finger] -- -- Q08288 Cell growth-regulating nucleolar protein Lyar 484.2 478.2 766 456.3 434.4 496 1.24641234585707 0.303904102789643 0.317781428642643 Nonsignificant None -- -- cell growth-regulating nucleolar protein -- -- Cell growth-regulating nucleolar protein D Cell cycle control, cell division, chromosome partitioning ; IPR014898 [Zinc finger, C2H2, LYAR-type] -- -- Q05BH3 DEAH (Asp-Glu-Ala-His) box polypeptide 16 Dhx16 442.2 433.6 413 391.4 412.5 393.2 1.0766017876535 0.0496818128555612 0.106484726008429 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 3.6.4.13 ko03040 Spliceosome mRNA splicing factor ATP-dependent RNA helicase A RNA processing and modification ; IPR011545 [DEAD/DEAH box helicase domain] -- -- A0A1D5RM83 IQ motif and SEC7 domain-containing protein 1 Iqsec1 122.8 129.8 117.6 130.5 142.6 134.6 0.908020603384842 0.0671827831849708 -0.139203061617973 Nonsignificant None 2 Molecular Function:ARF guanyl-nucleotide exchange factor activity (GO:0005086),Biological Process:regulation of ARF protein signal transduction (GO:0032012) IQ motif and SEC7 domain-containing protein -- ko04144 Endocytosis Predicted guanine nucleotide exchange factor, contains Sec7 domain U Intracellular trafficking, secretion, and vesicular transport ; IPR000904 [Sec7 domain] ; IPR033742[IQ motif and SEC7 domain-containing protein, PH domain] -- -- H3BJ02 Syntaxin 5A Stx5a 511.6 482 554.2 540.8 566 568.5 0.923894227899481 0.135063471448422 -0.114200400842981 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) syntaxin 5 -- ko04130 SNARE interactions in vesicular transport SNARE protein SED5/Syntaxin 5 U Intracellular trafficking, secretion, and vesicular transport ; IPR000727 [Target SNARE coiled-coil homology domain] -- -- Q8CAW4 Uncharacterized protein Pecam1 170.9 183.2 170.6 185.8 175.7 174.5 0.978917910447761 0.529907430291417 -0.0307402107023258 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) platelet/endothelial cell adhesion molecule -- ko04514 Cell adhesion molecules (CAMs) ko04670 Leukocyte transendothelial migration ko05144 Malaria ko05418 Fluid shear stress and atherosclerosis -- -- -- IPR007110 [Immunoglobulin-like domain] -- -- Q8BK30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial Ndufv3 660 728 624 694 648.8 751.1 0.960886384259038 0.555564637358471 -0.0575622388688206 Nonsignificant None 2 Cellular Component:mitochondrion (GO:0005739),Cellular Component:mitochondrial respiratory chain complex I (GO:0005747) NADH dehydrogenase (ubiquinone) flavoprotein 3 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease -- -- -- IPR026193 [NADH-ubiquinone oxidoreductase flavoprotein 3] -- -- Q05DA2 Translocation protein SEC62 (Fragment) Sec62 1337.2 1496.4 1456.5 1407.2 1504 1342.8 1.00848613070052 0.866089943062499 0.0121912432893246 Nonsignificant None -- -- translocation protein SEC62 -- ko03060 Protein export ko04141 Protein processing in endoplasmic reticulum Membrane component of ER protein translocation complex U Intracellular trafficking, secretion, and vesicular transport ; -- -- -- Q3UNZ8 Quinone oxidoreductase-like protein 2 Cryzl2 216 181.3 180 246.5 212.9 265.5 0.796385708373569 0.064043541302676 -0.328460763637564 Nonsignificant None 1 Biological Process:oxidation-reduction process (GO:0055114) -- -- -- Zinc-binding oxidoreductase CR Energy production and conversion ; General function prediction only ; IPR013149 [Alcohol dehydrogenase, C-terminal] ; IPR013154[Alcohol dehydrogenase, N-terminal] -- -- A2BE28 Ribosomal biogenesis protein LAS1L Las1l 273.5 285.9 330.3 357.4 357.5 341 0.84259873094043 0.0375881368186601 -0.24708235186558 Nonsignificant None -- -- ribosomal biogenesis protein LAS1 -- -- Nuclear protein involved in cell morphogenesis and cell surface growth R General function prediction only ; IPR007174 [Las1-like] -- -- Q3URR4 Uncharacterized protein (Fragment) Sgsh 464.9 448.6 483 569.5 515 557.4 0.850539009683903 0.0132350633087011 -0.233550688761332 Nonsignificant None 2 Biological Process:metabolic process (GO:0008152),Molecular Function:sulfuric ester hydrolase activity (GO:0008484) N-sulfoglucosamine sulfohydrolase 3.10.1.1 ko00531 Glycosaminoglycan degradation ko01100 Metabolic pathways ko04142 Lysosome Sulfatase R General function prediction only ; IPR000917 [Sulfatase, N-terminal] ; IPR032506[Domain of unknown function DUF4976] -- -- Q8VCT4 Carboxylesterase 1D Ces1d 85.3 82.7 106.6 203.5 173.5 184.6 0.488960113960114 0.00116976981002311 -1.03221131015746 Significant down -- -- carboxylesterase 1 3.1.1.1 ko00983 Drug metabolism - other enzymes ko01100 Metabolic pathways Carboxylesterase and related proteins R General function prediction only ; IPR002018 [Carboxylesterase, type B] -- -- P22005 Proenkephalin-A Penk 507.7 508.6 631.1 690 845.9 699 0.737124703566155 0.0395560891313711 -0.440019386018193 Nonsignificant None 1 Biological Process:neuropeptide signaling pathway (GO:0007218) proenkephalin A -- -- -- -- -- IPR006024 [Opioid neuropeptide precursor] -- -- Q64261 Cyclin-dependent kinase 6 Cdk6 365.7 397 406.1 423.9 436.6 384.8 0.93856901951337 0.267568727046903 -0.0914652545212657 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) cyclin-dependent kinase 6 2.7.11.22 ko04110 Cell cycle ko04115 p53 signaling pathway ko04151 PI3K-Akt signaling pathway ko04218 Cellular senescence ko05161 Hepatitis B ko05162 Measles ko05165 Human papillomavirus infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05206 MicroRNAs in cancer ko05212 Pancreatic cancer ko05214 Glioma ko05218 Melanoma ko05220 Chronic myeloid leukemia ko05222 Small cell lung cancer ko05223 Non-small cell lung cancer ko05224 Breast cancer ko05225 Hepatocellular carcinoma Protein kinase PCTAIRE and related kinases R General function prediction only ; IPR000719 [Protein kinase domain] -- -- Q6NSR2 Sfrs11 protein (Fragment) Srsf11 846.6 787.9 669 603.1 593.2 581.3 1.29584833483348 0.0764501880668497 0.373896876102482 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) splicing factor, arginine/serine-rich 11 -- -- Splicing factor, arginine/serine-rich A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- P39098 Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB Man1a2 425.1 398.2 484.9 495.2 506.2 512.8 0.863954563465857 0.058320922249495 -0.2109726537789 Nonsignificant None 3 Molecular Function:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity (GO:0004571),Molecular Function:calcium ion binding (GO:0005509),Cellular Component:membrane (GO:0016020) mannosyl-oligosaccharide alpha-1,2-mannosidase 3.2.1.113 ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways ko04141 Protein processing in endoplasmic reticulum Mannosyl-oligosaccharide alpha-1,2-mannosidase and related glycosyl hydrolases G Carbohydrate transport and metabolism ; IPR001382 [Glycoside hydrolase family 47] -- -- E0CX53 TBC1 domain family member 4 Tbc1d4 291.4 269 332.5 280.5 311.7 281.9 1.02150783663196 0.782204836536602 0.0307002719386928 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) TBC1 domain family member 4 -- ko04919 Thyroid hormone signaling pathway ko04931 Insulin resistance Predicted GTPase activator NB4S/EVI5 (contains TBC domain)/Calmodulin-binding protein Pollux (contains PTB and TBC domains) R General function prediction only ; IPR000195 [Rab-GTPase-TBC domain] ; IPR006020[PTB/PI domain] ; IPR021785[Domain of unknown function DUF3350] -- -- P61458 Pterin-4-alpha-carbinolamine dehydratase Pcbd1 706.9 736.8 907 1106 949.6 870.7 0.803301096948365 0.10829517116345 -0.31598724829814 Nonsignificant None 2 Biological Process:tetrahydrobiopterin biosynthetic process (GO:0006729),Molecular Function:4-alpha-hydroxytetrahydrobiopterin dehydratase activity (GO:0008124) 4a-hydroxytetrahydrobiopterin dehydratase 4.2.1.96 ko00790 Folate biosynthesis Pterin carbinolamine dehydratase PCBD/dimerization cofactor of HNF1 K Transcription ; IPR001533 [Transcriptional coactivator/pterin dehydratase] -- -- Q3UJ02 HBS1-like protein Hbs1l 467.4 477 442.1 435.1 431.5 452.7 1.05093610247859 0.142643968108411 0.071674955275686 Nonsignificant None -- -- elongation factor 1 alpha-like protein -- ko03015 mRNA surveillance pathway ko05134 Legionellosis Elongation factor 1 alpha J Translation, ribosomal structure and biogenesis ; IPR004160 [Translation elongation factor EFTu/EF1A, C-terminal] ; IPR015033[HBS1-like protein, N-terminal] -- -- Q3URK9 Uncharacterized protein Trim2 567.8 595.1 684.4 763 779.6 690.9 0.827087530781285 0.0444566816701168 -0.273888076806746 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Cellular Component:intracellular (GO:0005622),Molecular Function:zinc ion binding (GO:0008270) tripartite motif-containing protein 2/3 -- -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR000315 [B-box-type zinc finger] ; IPR001258[NHL repeat] ; IPR017868[Filamin/ABP280 repeat-like] ; IPR027370[RING-type zinc-finger, LisH dimerisation motif] -- -- Q91XU3 Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Pip4k2c 410.8 398.4 361.3 370.8 372.2 391.3 1.03191395574363 0.499591476827996 0.0453226792909844 Nonsignificant None 2 Molecular Function:phosphatidylinositol phosphate kinase activity (GO:0016307),Biological Process:phosphatidylinositol metabolic process (GO:0046488) 1-phosphatidylinositol-5-phosphate 4-kinase 2.7.1.149 ko00562 Inositol phosphate metabolism ko04070 Phosphatidylinositol signaling system ko04810 Regulation of actin cytoskeleton Phosphatidylinositol-4-phosphate 5-kinase T Signal transduction mechanisms ; IPR002498 [Phosphatidylinositol-4-phosphate 5-kinase, core] -- -- A0A0J9YVE6 Maltase-glucoamylase Mgam 192.7 172.2 213.8 158.8 177.9 177.1 1.12631374075516 0.185152189077834 0.171608753869443 Nonsignificant None 1 Biological Process:carbohydrate metabolic process (GO:0005975) -- -- ko00052 Galactose metabolism ko00500 Starch and sucrose metabolism ko01100 Metabolic pathways ko04973 Carbohydrate digestion and absorption Maltase glucoamylase and related hydrolases, glycosyl hydrolase family 31 G Carbohydrate transport and metabolism ; IPR000322 [Glycoside hydrolase family 31] ; IPR000519[P-type trefoil domain] ; IPR031727[Galactose mutarotase, N-terminal barrel] -- -- Q14B21 39S ribosomal protein L9, mitochondrial Mrpl9 605.6 585.8 819 824.3 834.1 804.4 0.816306642845542 0.179235398702745 -0.292816897334432 Nonsignificant None -- -- large subunit ribosomal protein L9 -- ko03010 Ribosome Mitochondrial ribosomal protein L9 J Translation, ribosomal structure and biogenesis ; IPR020070 [Ribosomal protein L9, N-terminal] -- -- F7CUP3 N-acetylglucosamine-6-phosphate deacetylase Amdhd2 542.1 551.8 545.9 624.8 656.3 615.5 0.86459981018665 0.00249842737935823 -0.209895575381291 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) N-acetylglucosamine-6-phosphate deacetylase 3.5.1.25 ko00520 Amino sugar and nucleotide sugar metabolism N-acetyl-glucosamine-6-phosphate deacetylase G Carbohydrate transport and metabolism ; IPR006680 [Amidohydrolase-related] -- -- Q9QXA3 Fat 1 cadherin (Fragment) Fat1 583.8 599 554.5 534.9 584.8 564.7 1.03140584184279 0.417216537874768 0.0446121220418163 Nonsignificant None 4 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:protein binding (GO:0005515),Biological Process:homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156),Cellular Component:membrane (GO:0016020) protocadherin Fat 1/2/3 -- -- Uncharacterized conserved protein, contains laminin, cadherin and EGF domains T Signal transduction mechanisms ; IPR000742 [EGF-like domain] ; IPR001791[Laminin G domain] ; IPR002126[Cadherin] -- -- P06684 Complement C5 C5 780.8 812.7 681.7 556.8 624.1 591.2 1.28390045708481 0.0188704432569189 0.360533352275549 Nonsignificant None 3 Molecular Function:endopeptidase inhibitor activity (GO:0004866),Cellular Component:extracellular region (GO:0005576),Cellular Component:extracellular space (GO:0005615) complement component 5 -- ko04610 Complement and coagulation cascades ko05020 Prion diseases ko05133 Pertussis ko05150 Staphylococcus aureus infection ko05168 Herpes simplex infection ko05322 Systemic lupus erythematosus Alpha-macroglobulin O Posttranslational modification, protein turnover, chaperones ; IPR000020 [Anaphylatoxin/fibulin] ; IPR001599[Alpha-2-macroglobulin] ; IPR002890[Alpha-2-macroglobulin, N-terminal] ; IPR009048[Alpha-macroglobulin, receptor-binding] ; IPR011625[Alpha-2-macroglobulin, N-terminal 2] ; IPR011626[Alpha-macroglobulin complement component] ; IPR018933[Netrin module, non-TIMP type] -- -- A0A0N4SVT1 RNA helicase (Fragment) Ddx47 717.7 843.1 760.5 688.7 713.4 698.2 1.1052230633719 0.120929576916182 0.144337573185133 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase DDX47/RRP3 3.6.4.13 -- ATP-dependent RNA helicase A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR011545[DEAD/DEAH box helicase domain] -- -- Q8VCZ6 Small G protein signaling modulator 3 Sgsm3 606.3 594 625.1 719.7 712.8 753.1 0.835193997071742 0.00145372863892801 -0.25981675226351 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) small G protein signaling modulator 3 -- -- Uncharacterized conserved protein, contains TBC, SH3 and RUN domains TR Signal transduction mechanisms ; General function prediction only ; IPR000195 [Rab-GTPase-TBC domain] ; IPR001452[SH3 domain] ; IPR004012[RUN domain] -- -- D3Z440 COP9 signalosome complex subunit 7a (Fragment) Cops7a 1232.3 1191.2 1307.8 1320.9 1330.9 1263.1 0.953102250376766 0.202157687037332 -0.0692970977528583 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) COP9 signalosome complex subunit 7 -- -- COP9 signalosome, subunit CSN7 OT Posttranslational modification, protein turnover, chaperones ; Signal transduction mechanisms ; IPR000717 [Proteasome component (PCI) domain] -- -- Q9D0I4 Syntaxin-17 Stx17 510.7 511.5 779.5 490.9 528.1 493.4 1.19128537423962 0.393917570386922 0.252519054414215 Nonsignificant None -- -- syntaxin 17 -- ko04130 SNARE interactions in vesicular transport ko04140 Autophagy - animal SNARE protein PEP12/VAM3/Syntaxin 7/Syntaxin 17 U Intracellular trafficking, secretion, and vesicular transport ; -- -- -- Q8R409 Protein HEXIM1 Hexim1 610 608.7 551.7 446.7 425.6 446.5 1.34243251440704 0.00181634400669028 0.424849564130624 Nonsignificant None 5 Biological Process:negative regulation of transcription from RNA polymerase II promoter (GO:0000122),Molecular Function:cyclin-dependent protein serine/threonine kinase inhibitor activity (GO:0004861),Cellular Component:nucleus (GO:0005634),Cellular Component:cytoplasm (GO:0005737),Molecular Function:snRNA binding (GO:0017069) protein HEXIM1/2 -- -- -- -- -- IPR024872 [HEXIM] -- -- A0A2U3TZ82 TRIO and F-actin-binding protein Triobp 1104 1217.5 1180.6 1453.6 1344.9 1313.9 0.851595175566579 0.0195994699573674 -0.231760318190024 Nonsignificant None -- -- -- -- -- F-actin binding protein, regulates actin cytoskeletal organization Z Cytoskeleton ; IPR001849 [Pleckstrin homology domain] -- -- A0A0G2JEX1 Nexilin Nexn 1671.9 1579.2 1659.5 1747.3 1850.9 1695.6 0.927613434583853 0.0776423950019658 -0.108404380264435 Nonsignificant None -- -- -- -- -- -- -- -- IPR013098 [Immunoglobulin I-set] -- -- Q99N93 39S ribosomal protein L16, mitochondrial Mrpl16 1281.6 1228.9 1383.1 1276.9 1287.8 1249.1 1.02092401279564 0.599374640344383 0.0298754906598473 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L16 -- ko03010 Ribosome Mitochondrial ribosomal protein L16 J Translation, ribosomal structure and biogenesis ; IPR016180 [Ribosomal protein L10e/L16] -- -- Q9D8C4 Interferon-induced 35 kDa protein homolog Ifi35 315.9 298.6 309.4 338.5 333.6 342.3 0.910784700315457 0.00588611241830501 -0.134818038112442 Nonsignificant None -- -- -- -- -- -- -- -- IPR009909 [Nmi/IFP 35 domain] ; IPR009938[Nmi/IFP 35 domain, N-terminal] -- -- Q9D7E4 UPF0449 protein C19orf25 homolog 221.1 222.4 234.6 197.6 229.6 202.8 1.07634920634921 0.212052624457772 0.106146215937547 Nonsignificant None -- -- -- -- -- -- -- -- IPR028227 [Uncharacterised protein family UPF0449] -- -- Q9CQF7 Prefoldin 1 Pfdn1 1468.9 1474.1 1375.4 1305.4 1339.5 1366.8 1.07645137971434 0.0493718324037514 0.106283158493442 Nonsignificant None 3 Biological Process:protein folding (GO:0006457),Cellular Component:prefoldin complex (GO:0016272),Molecular Function:unfolded protein binding (GO:0051082) prefoldin subunit 1 -- -- Molecular chaperone Prefoldin, subunit 1 O Posttranslational modification, protein turnover, chaperones ; IPR002777 [Prefoldin beta-like] -- -- Q9D1N9 39S ribosomal protein L21, mitochondrial Mrpl21 345.2 317.4 293.4 262.3 248.4 270 1.22454207762265 0.0228261622515176 0.292242348531976 Nonsignificant None 1 Cellular Component:ribosome (GO:0005840) large subunit ribosomal protein L21 -- ko03010 Ribosome Mitochondrial/chloroplast ribosomal L21 protein J Translation, ribosomal structure and biogenesis ; IPR028909 [Ribosomal protein L21-like] -- -- Q3TMV8 DCN1-like protein 616.2 583.5 758 725 682.1 754.8 0.905546047458254 0.302496324770139 -0.143140090100015 Nonsignificant None -- -- DCN1-like protein 1/2 -- -- Uncharacterized conserved protein S Function unknown ; IPR005176 [Potentiating neddylation domain] -- -- Q9D0R4 Probable ATP-dependent RNA helicase DDX56 Ddx56 457.4 454.4 405.3 346.6 348.9 367.2 1.23939023242684 0.00941701796313762 0.309630503658653 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase DDX56/DBP9 3.6.4.13 -- RNA helicase A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR011545[DEAD/DEAH box helicase domain] -- -- B1AVH7 TBC1 domain family member 2A Tbc1d2 358.3 345.8 363.5 380.4 419.7 384.3 0.901384667342114 0.0454084834522149 -0.149785185035587 Nonsignificant None -- -- TBC1 domain family member 2A -- -- Ypt/Rab GTPase activating protein U Intracellular trafficking, secretion, and vesicular transport ; IPR000195 [Rab-GTPase-TBC domain] ; IPR001849[Pleckstrin homology domain] -- -- Q6A0A1 RNA helicase (Fragment) mKIAA0224 432.1 385.3 360.8 373.9 391.2 379.3 1.02953512757777 0.628425914100983 0.041993055339442 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:helicase activity (GO:0004386),Molecular Function:ATP binding (GO:0005524) pre-mRNA-splicing factor ATP-dependent RNA helicase DHX38/PRP16 3.6.4.13 ko03040 Spliceosome mRNA splicing factor ATP-dependent RNA helicase A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR007502[Helicase-associated domain] ; IPR011545[DEAD/DEAH box helicase domain] ; IPR011709[Domain of unknown function DUF1605] -- -- Q925B0 PRKC apoptosis WT1 regulator protein Pawr 714.9 747.9 679.7 724.1 745.6 680.2 0.996557979440904 0.932921761892685 -0.00497435182147322 Nonsignificant None -- -- -- -- -- -- -- -- -- -- TF_bZIP P42128 Forkhead box protein K1 Foxk1 423.1 411.1 400.3 368 380 360 1.11416967509025 0.0086415678825139 0.155968955093594 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:sequence-specific DNA binding (GO:0043565) forkhead box protein K -- -- Transcription factor of the Forkhead/HNF3 family K Transcription ; IPR000253 [Forkhead-associated (FHA) domain] ; IPR001766[Fork head domain] -- Fork head P55095 Pro-glucagon Gcg 549.6 481.4 615.7 805 860.8 780.6 0.673111510791367 0.00422263147397795 -0.571082566665091 Nonsignificant None 2 Molecular Function:hormone activity (GO:0005179),Cellular Component:extracellular region (GO:0005576) glucagon -- ko04911 Insulin secretion ko04922 Glucagon signaling pathway -- -- -- IPR000532 [Glucagon/GIP/secretin/VIP] -- -- C0HKD9 Microfibrillar-associated protein 1B Mfap1b 1081.1 1121 911.6 813.9 819.2 928 1.21576666276209 0.0679875830128977 0.28186636465455 Nonsignificant None -- -- microfibrillar-associated protein 1 -- -- Microfibrillar-associated protein MFAP1 Z Cytoskeleton ; IPR009730 [Micro-fibrillar-associated protein 1, C-terminal] -- -- Q61164 Transcriptional repressor CTCF Ctcf 927.6 904.8 880.6 908.7 931.4 944.7 0.97421717897156 0.235650930662268 -0.037684671554454 Nonsignificant None -- -- -- -- -- FOG: Zn-finger R General function prediction only ; -- -- zf-C2H2 Q8R123 FAD synthase Flad1 333.6 280.1 323.4 376.1 382.9 396.5 0.810990913024665 0.0140417404478504 -0.302242345435811 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) FAD synthetase 2.7.7.2 ko00740 Riboflavin metabolism ko01100 Metabolic pathways 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes EH Amino acid transport and metabolism ; Coenzyme transport and metabolism ; IPR001453 [MoaB/Mog domain] ; IPR002500[Phosphoadenosine phosphosulphate reductase] -- -- A2AG30 DnaJ homolog subfamily B member 5 Dnajb5 836.7 971.3 943.2 1150.1 1097.6 1021.4 0.841577192499465 0.0357869174966582 -0.248832488063446 Nonsignificant None -- -- DnaJ homolog subfamily B member 5 -- -- Molecular chaperone (DnaJ superfamily) O Posttranslational modification, protein turnover, chaperones ; IPR001623 [DnaJ domain] ; IPR002939[Chaperone DnaJ, C-terminal] -- -- H7BWY8 Pre-rRNA-processing protein TSR2 homolog Tsr2 512 530 514.3 510.4 490.2 506.5 1.03264547807047 0.122041610515143 0.0463450414086412 Nonsignificant None -- -- pre-rRNA-processing protein TSR2 -- -- Uncharacterized conserved protein S Function unknown ; IPR019398 [Pre-rRNA-processing protein TSR2] -- -- Q9CRA8 Exosome complex component RRP46 Exosc5 508.8 516.4 523.7 489.3 508.6 464.4 1.0592217739178 0.0992331512079774 0.0830046843578035 Nonsignificant None -- -- exosome complex component RRP46 -- ko03018 RNA degradation Exosomal 3'-5' exoribonuclease complex, subunit Rrp46 J Translation, ribosomal structure and biogenesis ; IPR001247 [Exoribonuclease, phosphorolytic domain 1] ; IPR015847[Exoribonuclease, phosphorolytic domain 2] -- -- O55229 Choline/ethanolamine kinase Chkb 637.2 631.3 522.9 626.7 670.9 588.7 0.949689869055824 0.51282858991939 -0.0744716313624532 Nonsignificant None -- -- -- -- ko00564 Glycerophospholipid metabolism ko01100 Metabolic pathways ko05231 Choline metabolism in cancer Choline kinase M Cell wall/membrane/envelope biogenesis ; -- -- -- Q6GU68 Immunoglobulin superfamily containing leucine-rich repeat protein Islr 386.4 412.9 500.6 396.3 405.4 405.8 1.07652173913043 0.466537033403566 0.106377453382527 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- FOG: Leucine rich repeat R General function prediction only ; IPR001611 [Leucine-rich repeat] ; IPR013098[Immunoglobulin I-set] -- -- Q5M9J2 Histidine triad nucleotide binding protein 2 Hint2 335.2 340.6 478.1 430.1 403.5 415.4 0.923859087269816 0.540156785019942 -0.114255275280755 Nonsignificant None -- -- -- -- -- Zinc-binding protein of the histidine triad (HIT) family T Signal transduction mechanisms ; IPR001310 [Histidine triad (HIT) protein] -- -- Q9QXV0 ProSAAS Pcsk1n 469.5 429.3 619.8 897.4 902.7 1085.8 0.526213659516962 0.00579796932254951 -0.926279396247476 Significant down 2 Molecular Function:endopeptidase inhibitor activity (GO:0004866),Biological Process:negative regulation of endopeptidase activity (GO:0010951) -- -- -- -- -- -- IPR010832 [ProSAAS] -- -- Q497Z4 Rhpn2 protein Rhpn2 839 818 971.5 1014.8 989.9 1013 0.871027603804222 0.0562072916710968 -0.199209654776859 Nonsignificant None 1 Biological Process:signal transduction (GO:0007165) -- -- -- Predicted signal transduction protein R General function prediction only ; IPR004328 [BRO1 domain] ; IPR011072[HR1 rho-binding repeat] -- -- Q9CQ06 39S ribosomal protein L24, mitochondrial Mrpl24 1158.7 1076.8 1186.9 1133 1197.7 1204.5 0.968092328581127 0.401694328617973 -0.0467834485919614 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L24 -- ko03010 Ribosome Mitochondrial/chloroplast ribosomal protein L24 J Translation, ribosomal structure and biogenesis ; IPR003256 [Ribosomal protein L24] ; IPR005824[KOW] -- -- Q8BGC0 HIV Tat-specific factor 1 homolog Htatsf1 148.2 139.1 142.3 156.7 166.3 152.5 0.903470031545741 0.0349387289222044 -0.146451347762513 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) HIV Tat-specific factor 1 -- -- Transcription elongation factor TAT-SF1 K Transcription ; IPR000504 [RNA recognition motif domain] -- -- Q9CQR4 Acyl-coenzyme A thioesterase 13 Acot13 566.6 555.3 732.5 781.5 750.7 770.8 0.805210594876248 0.117366343507828 -0.312561939673736 Nonsignificant None -- -- acyl-coenzyme A thioesterase 13 3.1.2.- -- HGG motif-containing thioesterase R General function prediction only ; IPR006683 [Thioesterase domain] -- -- Q99ME9 GTP-binding protein 4 Gtpbp4 835.8 858.7 763.3 695.5 692.6 688.9 1.18334135772749 0.0471108644903372 0.242866307035098 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) nucleolar GTP-binding protein -- ko03008 Ribosome biogenesis in eukaryotes GTP-binding protein CRFG/NOG1 (ODN superfamily) R General function prediction only ; IPR010674 [Nucleolar GTP-binding protein 1, Rossman-fold domain] ; IPR012973[NOG, C-terminal] -- -- P70280 Vesicle-associated membrane protein 7 Vamp7 318.4 320.9 349.8 353.1 355.9 352.9 0.931443638760712 0.136422417915729 -0.102459619913094 Nonsignificant None 2 Cellular Component:integral component of membrane (GO:0016021),Biological Process:vesicle-mediated transport (GO:0016192) vesicle-associated membrane protein 7 -- ko04130 SNARE interactions in vesicular transport Synaptobrevin/VAMP-like protein U Intracellular trafficking, secretion, and vesicular transport ; IPR001388 [Synaptobrevin] ; IPR010908[Longin domain] -- -- Q80VJ3 2-deoxynucleoside 5-phosphate N-hydrolase 1 Dnph1 650.6 686.6 503.3 322.8 417.9 449.1 1.54689863842663 0.0328182773511467 0.629378666321419 Significant up 3 Biological Process:deoxyribonucleoside monophosphate catabolic process (GO:0009159),Molecular Function:nucleoside deoxyribosyltransferase activity (GO:0050144),Molecular Function:deoxyribonucleoside 5'-monophosphate N-glycosidase activity (GO:0070694) -- -- -- -- -- -- IPR007710 [Nucleoside 2-deoxyribosyltransferase] -- -- Q7TN29 Stromal membrane-associated protein 2 Smap2 896.2 888.7 835 716.4 729.9 715.6 1.21185068689579 0.00152934962904544 0.277211954136717 Nonsignificant None 1 Molecular Function:GTPase activator activity (GO:0005096) stromal membrane-associated protein -- ko04144 Endocytosis Predicted GTPase-activating protein T Signal transduction mechanisms ; IPR001164 [Arf GTPase activating protein] -- -- P56380 Bis(5-nucleosyl)-tetraphosphatase [asymmetrical] Nudt2 837.3 842.6 689.1 746.1 706.2 744.4 1.07843583557154 0.331068249937153 0.108940342046324 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) bis(5'-nucleosidyl)-tetraphosphatase 3.6.1.17 ko00230 Purine metabolism ko00240 Pyrimidine metabolism Diadenosine and diphosphoinositol polyphosphate phosphohydrolase T Signal transduction mechanisms ; IPR000086 [NUDIX hydrolase domain] -- -- Q63961 Endoglin Eng 308.1 334 330.3 249.9 255.4 282.7 1.23401015228426 0.00904679565039489 0.30335426368499 Nonsignificant None -- -- endoglin -- -- -- -- -- IPR001507 [Zona pellucida domain] -- -- O89051 Integral membrane protein 2B Itm2b 227.5 232.3 235.2 291.4 335.1 299.8 0.750296880060456 0.00474330025346562 -0.414466535755236 Nonsignificant None -- -- integral membrane protein 2B -- -- Uncharacterized conserved protein S Function unknown ; IPR007084 [BRICHOS domain] -- -- Q3UVJ7 Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] Decr2 709.7 559.4 747.9 812.3 637.9 892.6 0.860935632576404 0.315264429474457 -0.216022715609194 Nonsignificant None -- -- peroxisomal 2,4-dienoyl-CoA reductase 1.3.1.34 ko04146 Peroxisome Reductases with broad range of substrate specificities R General function prediction only ; -- -- -- Q9R0P9 Ubiquitin carboxyl-terminal hydrolase isozyme L1 Uchl1 720.4 616.6 655 736 703.6 835.6 0.875527426160338 0.131799415579279 -0.191775722663972 Nonsignificant None 3 Molecular Function:thiol-dependent ubiquitin-specific protease activity (GO:0004843),Cellular Component:intracellular (GO:0005622),Biological Process:ubiquitin-dependent protein catabolic process (GO:0006511) ubiquitin carboxyl-terminal hydrolase L1 3.4.19.12 ko05012 Parkinson's disease Ubiquitin C-terminal hydrolase UCHL1 O Posttranslational modification, protein turnover, chaperones ; IPR001578 [Peptidase C12, ubiquitin carboxyl-terminal hydrolase] -- -- Q9D1M7 Peptidyl-prolyl cis-trans isomerase FKBP11 Fkbp11 1299.3 1250.9 1385.9 1324.8 1516.4 1108.7 0.99650624066432 0.972231889765281 -0.00504925485336027 Nonsignificant None -- -- FK506-binding protein 11 5.2.1.8 -- FKBP-type peptidyl-prolyl cis-trans isomerase O Posttranslational modification, protein turnover, chaperones ; IPR001179 [FKBP-type peptidyl-prolyl cis-trans isomerase domain] -- -- Q8BYY4 Tetratricopeptide repeat protein 39B Ttc39b 277.7 259.3 218.2 240.6 274.9 263.3 0.96969696969697 0.717691456964327 -0.0443941193584536 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019412 [Outer membrane protein Iml2/Tetratricopeptide repeat protein 39] ; IPR019734[Tetratricopeptide repeat] -- -- G5E911 Protein FAM3C Fam3c 751.8 763.2 703.1 701.8 766.7 682.2 1.03133863393314 0.514991362321994 0.0445181108648234 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- A0A0R4IZX2 Na(+)/H(+) exchange regulatory cofactor NHE-RF Slc9a3r2 1042.6 976.7 973.7 1108.2 1117.3 1169.9 0.881486717323438 0.0105472039670733 -0.18198926441846 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) Na(+)/H(+) exchange regulatory cofactor NHE-RF2 -- ko04960 Aldosterone-regulated sodium reabsorption FOG: PDZ domain S Function unknown ; IPR001478 [PDZ domain] ; IPR015098[EBP50, C-terminal] -- -- P62743 AP-2 complex subunit sigma Ap2s1 751.1 743.2 722.3 732.1 773.7 774 0.972278270023686 0.26718615653978 -0.0405588167269393 Nonsignificant None -- -- AP-2 complex subunit sigma-1 -- ko04144 Endocytosis ko04721 Synaptic vesicle cycle ko04961 Endocrine and other factor-regulated calcium reabsorption ko05016 Huntington's disease Clathrin adaptor complex, small subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR022775 [AP complex, mu/sigma subunit] -- -- Q3UMW7 MAP kinase-activated protein kinase 3 Mapkapk3 84 65.9 68.1 61.9 57.8 63.4 1.19060622610595 0.121891421122482 0.251696343866952 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) mitogen-activated protein kinase-activated protein kinase 3 2.7.11.1 ko04010 MAPK signaling pathway ko04370 VEGF signaling pathway MAP kinase-activated protein kinase 2 T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q8C1E7 Ion channel TACAN Tmem120a 1052.2 1025.3 885 838.7 888.2 900.3 1.12762637028015 0.112666024508879 0.173289121782541 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) -- -- -- Predicted membrane protein R General function prediction only ; IPR012926 [TMPIT-like] -- -- Q80UJ8 Lactb protein Lactb 556.1 560.9 506.1 518.4 490 533.7 1.05252577653849 0.281349965730239 0.0738555655756388 Nonsignificant None -- -- serine beta-lactamase-like protein LACTB, mitochondrial -- -- -- -- -- IPR001466 [Beta-lactamase-related] -- -- Q9D7N6 39S ribosomal protein L30, mitochondrial Mrpl30 1125.6 1112.9 953.9 884.3 945.6 876.8 1.17944360291129 0.052635515505279 0.238106435325625 Nonsignificant None -- -- large subunit ribosomal protein L30 -- ko03010 Ribosome Mitochondrial ribosomal protein L30 J Translation, ribosomal structure and biogenesis ; IPR016082 [Ribosomal protein L30, ferredoxin-like fold domain] -- -- E9Q2B2 Nuclear receptor corepressor 1 Ncor1 329.8 290.4 269.3 288.6 287.6 275.5 1.04438182458612 0.527310512207285 0.0626492557089743 Nonsignificant None -- -- nuclear receptor co-repressor 1 -- ko01522 Endocrine resistance ko04919 Thyroid hormone signaling pathway ko05202 Transcriptional misregulation in cancer Nuclear receptor coregulator SMRT/SMRTER, contains Myb-like domains K Transcription ; IPR001005 [SANT/Myb domain] ; IPR031557[N-CoR, GPS2-interacting domain] -- MYB Q14DT6 Complement component 1, s subcomponent C1s1 412.4 408.8 413.2 368.6 369.3 382 1.1022412715421 0.00111447069561589 0.140440052546509 Nonsignificant None 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) complement component 1, s subcomponent 3.4.21.42 ko04610 Complement and coagulation cascades ko05133 Pertussis ko05150 Staphylococcus aureus infection ko05322 Systemic lupus erythematosus Trypsin E Amino acid transport and metabolism ; IPR000436 [Sushi/SCR/CCP domain] ; IPR000859[CUB domain] ; IPR001254[Serine proteases, trypsin domain] -- -- A0A1L1SUX8 Thy-1 membrane glycoprotein (Fragment) Thy1 418.1 381.4 367.1 392.6 412.7 426.2 0.947300040600893 0.296977763846686 -0.0781066485725584 Nonsignificant None -- -- Thy-1 cell surface antigen -- ko04670 Leukocyte transendothelial migration -- -- -- IPR013151 [Immunoglobulin] -- -- Q8C0E2 Vacuolar protein sorting-associated protein 26B Vps26b 1545.9 1500.6 1657.9 1689.3 1734.8 1735.4 0.911793778466906 0.0367660601252153 -0.133220529735534 Nonsignificant None -- -- vacuolar protein sorting-associated protein 26 -- ko04144 Endocytosis Membrane coat complex Retromer, subunit VPS26 U Intracellular trafficking, secretion, and vesicular transport ; IPR028934 [Vacuolar protein sorting protein 26 related] -- -- Q3U3J1 2-oxoisovalerate dehydrogenase subunit alpha Bckdha 317 321.6 332.2 360.4 317.4 415.8 0.887710314557425 0.285998822978074 -0.171839134454926 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) 2-oxoisovalerate dehydrogenase E1 component alpha subunit 1.2.4.4 ko00280 Valine, leucine and isoleucine degradation ko00640 Propanoate metabolism ko01100 Metabolic pathways Branched chain alpha-keto acid dehydrogenase complex, alpha subunit C Energy production and conversion ; IPR001017 [Dehydrogenase, E1 component] -- -- Q8K3X6 Ankyrin repeat and SAM domain-containing protein 4B Anks4b 1092 1016.8 1278.7 1117.6 1137.5 1040.4 1.02791685631922 0.731405707905469 0.0397235759841638 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) ankyrin repeat and SAM domain-containing protein 4B -- -- FOG: Ankyrin repeat R General function prediction only ; IPR001660 [Sterile alpha motif domain] ; IPR020683[Ankyrin repeat-containing domain] -- -- Q8VD62 UPF0696 protein C11orf68 homolog Bles03 424.4 434.1 466.3 493.4 525.9 491.1 0.877118644067797 0.0216888685789119 -0.189156091862516 Nonsignificant None -- -- -- -- -- -- -- -- IPR015034 [Protein of unknown function DUF1917] -- -- O35309 N-myc-interactor Nmi 1288.7 1335.6 1679 1552.3 1552.8 1776.4 0.881552801393014 0.251464000090349 -0.181881111244929 Nonsignificant None -- -- -- -- -- -- -- -- IPR009909 [Nmi/IFP 35 domain] ; IPR009938[Nmi/IFP 35 domain, N-terminal] -- -- Q9CY16 28S ribosomal protein S28, mitochondrial Mrps28 1488.7 1448.4 1382.6 1431.4 1536.6 1539.3 0.958378630222084 0.254968609080271 -0.0613323553920739 Nonsignificant None -- -- small subunit ribosomal protein S28 -- -- Putative mitochondrial ribosomal protein mRpS35 J Translation, ribosomal structure and biogenesis ; IPR019375 [Ribosomal protein S28, mitochondrial] -- -- Q99N87 28S ribosomal protein S5, mitochondrial Mrps5 938 967.8 991.6 1030.1 1088.4 1000.4 0.928981371637436 0.0704745430330528 -0.106278427575176 Nonsignificant None 4 Molecular Function:RNA binding (GO:0003723),Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S5 -- ko03010 Ribosome Ribosomal protein S5 J Translation, ribosomal structure and biogenesis ; IPR005324 [Ribosomal protein S5, C-terminal] ; IPR013810[Ribosomal protein S5, N-terminal] -- -- Q9D952 Envoplakin Evpl 239.2 254.4 173.4 160.6 158.1 155.7 1.40598650927487 0.122418247422802 0.491582751525944 Nonsignificant None 1 Cellular Component:cytoskeleton (GO:0005856) envoplakin -- -- Dystonin, GAS (Growth-arrest-specific protein), and related proteins Z Cytoskeleton ; IPR001101 [Plectin repeat] -- -- B2RXX8 Non-specific serine/threonine protein kinase Cdc42bpa 177.3 180.6 176.9 163.4 177.6 169.9 1.04678019181836 0.135377514061085 0.0659585296936541 Nonsignificant None 5 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468),Biological Process:intracellular signal transduction (GO:0035556) serine/threonine-protein kinase MRCK 2.7.11.1 -- Rho-associated, coiled-coil containing protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR001180[Citron homology (CNH) domain] ; IPR002219[Protein kinase C-like, phorbol ester/diacylglycerol-binding domain] ; IPR014930[Myotonic dystrophy protein kinase, coiled coil] ; IPR017892[Protein kinase, C-terminal] ; IPR031597[KELK-motif containing domain] -- -- P28650 Adenylosuccinate synthetase isozyme 1 Adss1 50.1 53.3 49.5 51.3 46 46 1.06699232379623 0.206420955182391 0.0935497970986591 Nonsignificant None 3 Molecular Function:adenylosuccinate synthase activity (GO:0004019),Molecular Function:GTP binding (GO:0005525),Biological Process:purine nucleotide biosynthetic process (GO:0006164) adenylosuccinate synthase 6.3.4.4 ko00230 Purine metabolism ko00250 Alanine, aspartate and glutamate metabolism ko01100 Metabolic pathways Adenylosuccinate synthase F Nucleotide transport and metabolism ; IPR001114 [Adenylosuccinate synthetase] -- -- Q8R3N6 THO complex subunit 1 Thoc1 756 716.1 742.9 734.9 758.5 774.9 0.976502226336904 0.342511043135884 -0.0343047615571185 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Biological Process:signal transduction (GO:0007165) THO complex subunit 1 -- ko03013 RNA transport ko03040 Spliceosome Nuclear matrix protein Y Nuclear structure ; IPR000488 [Death domain] ; IPR021861[THO complex, subunit THOC1] -- -- O70274 Protein tyrosine phosphatase type IVA 2 Ptp4a2 1696.1 1780.2 1421.9 1526.3 1487.1 1519.8 1.08051707403159 0.377503930839803 0.111721869445067 Nonsignificant None 2 Molecular Function:protein tyrosine phosphatase activity (GO:0004725),Biological Process:protein dephosphorylation (GO:0006470) protein tyrosine phosphatase type IVA 3.1.3.48 -- Protein tyrosine phosphatase IVA1 T Signal transduction mechanisms ; IPR000242 [PTP type protein phosphatase] -- -- Q3U5H8 Heme oxygenase (biliverdin-producing) (Fragment) Hmox1 382.2 406.5 277 239.3 262.6 226.4 1.46327063023479 0.0521982307847218 0.549196618956916 Nonsignificant None 3 Molecular Function:heme oxygenase (decyclizing) activity (GO:0004392),Biological Process:heme oxidation (GO:0006788),Biological Process:oxidation-reduction process (GO:0055114) heme oxygenase 1 1.14.14.18 ko00860 Porphyrin and chlorophyll metabolism ko01100 Metabolic pathways ko04066 HIF-1 signaling pathway ko04216 Ferroptosis ko04978 Mineral absorption ko05200 Pathways in cancer ko05206 MicroRNAs in cancer ko05225 Hepatocellular carcinoma ko05418 Fluid shear stress and atherosclerosis Heme oxygenase P Inorganic ion transport and metabolism ; IPR016053 [Haem oxygenase-like] -- -- Q9CZ19 Myosin light chain 4 Myl4 924.7 1140.8 1409.8 906.3 842.9 796.6 1.36511116348496 0.0975922468191977 0.44901843720995 Nonsignificant None -- -- myosin light chain 4 -- ko04260 Cardiac muscle contraction ko04261 Adrenergic signaling in cardiomyocytes ko04371 Apelin signaling pathway Myosin essential light chain, EF-Hand protein superfamily Z Cytoskeleton ; -- -- -- P98083 SHC-transforming protein 1 Shc1 848.6 794.4 750.9 712.5 745.6 717.7 1.10023899255446 0.0729481548542566 0.137816938225049 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) SHC-transforming protein 1 -- ko01521 EGFR tyrosine kinase inhibitor resistance ko01522 Endocrine resistance ko04012 ErbB signaling pathway ko04014 Ras signaling pathway ko04062 Chemokine signaling pathway ko04072 Phospholipase D signaling pathway ko04510 Focal adhesion ko04650 Natural killer cell mediated cytotoxicity ko04722 Neurotrophin signaling pathway ko04910 Insulin signaling pathway ko04915 Estrogen signaling pathway ko04917 Prolactin signaling pathway ko04926 Relaxin signaling pathway ko05034 Alcoholism ko05100 Bacterial invasion of epithelial cells ko05206 MicroRNAs in cancer ko05214 Glioma ko05220 Chronic myeloid leukemia ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer Adaptor protein SHC and related proteins T Signal transduction mechanisms ; IPR000980 [SH2 domain] ; IPR006020[PTB/PI domain] -- -- Q8BLF1 Neutral cholesterol ester hydrolase 1 Nceh1 632.9 665.9 642.1 691.8 647.9 703.9 0.949745547073791 0.156432070259105 -0.074387052124065 Nonsignificant None 2 Biological Process:metabolic process (GO:0008152),Molecular Function:hydrolase activity (GO:0016787) neutral cholesterol ester hydrolase 1 3.1.1.- ko04976 Bile secretion ko04979 Cholesterol metabolism Arylacetamide deacetylase V Defense mechanisms ; IPR013094 [Alpha/beta hydrolase fold-3] -- -- Q3UYD0 Uncharacterized protein Utp14a 794.6 779.6 743.5 632.8 677.7 632.8 1.19266196675758 0.00423973495146124 0.254185201468361 Nonsignificant None 2 Biological Process:rRNA processing (GO:0006364),Cellular Component:small-subunit processome (GO:0032040) U3 small nucleolar RNA-associated protein 14 -- ko03008 Ribosome biogenesis in eukaryotes Uncharacterized conserved protein S Function unknown ; IPR006709 [Small-subunit processome, Utp14] -- -- Q9R059 Four and a half LIM domains protein 3 Fhl3 392.2 474.4 453.9 483.8 508.6 426.9 0.930388219544846 0.394710687290359 -0.104095265178367 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) -- -- -- FOG: LIM domain TZR Signal transduction mechanisms ; Cytoskeleton ; General function prediction only ; IPR001781 [Zinc finger, LIM-type] -- -- Q8BTS3 Guanylate-binding protein 9 Gbp9 493.2 491 520.7 512.3 525.7 485.1 0.988050686100716 0.711883522343429 -0.0173430422368223 Nonsignificant None 2 Molecular Function:GTPase activity (GO:0003924),Molecular Function:GTP binding (GO:0005525) guanylate-binding protein 6 -- -- Guanylate-binding protein R General function prediction only ; IPR003191 [Guanylate-binding protein, C-terminal] ; IPR015894[Guanylate-binding protein, N-terminal] -- -- Q542P4 55 kDa erythrocyte membrane protein Mpp1 443.9 449.1 562.4 503.5 529.4 515.7 0.939816608549658 0.47429737563718 -0.0895488314465836 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) 55 kDa erythrocyte membrane protein -- -- Calcium/calmodulin-dependent serine protein kinase/membrane-associated guanylate kinase T Signal transduction mechanisms ; IPR001478 [PDZ domain] ; IPR008145[Guanylate kinase/L-type calcium channel beta subunit] ; IPR011511[Variant SH3 domain] -- -- Q99L48 60S ribosomal export protein NMD3 Nmd3 390.2 412.2 407.7 381 407.4 403.8 1.01501425935246 0.605086073068749 0.0214999951469787 Nonsignificant None -- -- nonsense-mediated mRNA decay protein 3 -- ko03008 Ribosome biogenesis in eukaryotes ko03013 RNA transport NMD protein affecting ribosome stability and mRNA decay J Translation, ribosomal structure and biogenesis ; IPR007064 [NMD3] -- -- F2Z3U3 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 Raph1 1032.6 1137.6 746.2 646.4 688 719.6 1.41986368062317 0.0728909568215369 0.505752424990863 Nonsignificant None 1 Biological Process:signal transduction (GO:0007165) -- -- -- Growth factor receptor-bound proteins (GRB7, GRB10, GRB14) T Signal transduction mechanisms ; IPR000159 [Ras-associating (RA) domain] ; IPR001849[Pleckstrin homology domain] -- -- A2ADH1 Magnesium transporter protein 1 Magt1 1285.3 1334.9 1440.5 1540.1 1533.5 1438.2 0.900017731282415 0.0559672797867867 -0.151974670577025 Nonsignificant None -- -- magnesium transporter 1 -- -- Oligosaccharyltransferase, gamma subunit O Posttranslational modification, protein turnover, chaperones ; IPR021149 [Oligosaccharyl transferase complex, subunit OST3/OST6] -- -- Q921J2 GTP-binding protein Rheb Rheb 1004.5 997.4 1029.2 986.5 968 967 1.03751497518398 0.0339545866136429 0.0531321600429333 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras homolog enriched in brain -- ko04072 Phospholipase D signaling pathway ko04140 Autophagy - animal ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04152 AMPK signaling pathway ko04211 Longevity regulating pathway ko04218 Cellular senescence ko04910 Insulin signaling pathway ko04919 Thyroid hormone signaling pathway ko05165 Human papillomavirus infection ko05231 Choline metabolism in cancer Ras-related GTPase R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- E9Q7P9 Cadherin-related family member 2 Cdhr2 395.7 362.7 481.4 525.5 552.6 469.5 0.801111398294133 0.0755419248540339 -0.319925224797709 Nonsignificant None 3 Molecular Function:calcium ion binding (GO:0005509),Biological Process:homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156),Cellular Component:membrane (GO:0016020) cadherin-related family member 2 -- -- FOG: Cadherin repeats S Function unknown ; IPR002126 [Cadherin] -- -- P06330 Ig heavy chain V region AC38 205.12 390.6 367.5 233 127.4 115 128.6 2.67142857142857 0.0511136599296073 1.41761144294267 Nonsignificant None -- -- -- -- -- -- -- -- IPR013106 [Immunoglobulin V-set domain] -- -- Q91VS8 FERM, ARHGEF and pleckstrin domain-containing protein 2 Farp2 622.3 606.6 563.8 706.4 693.5 640.5 0.87860223485591 0.036433311840941 -0.18671792574187 Nonsignificant None 2 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Biological Process:regulation of Rho protein signal transduction (GO:0035023) FERM, RhoGEF and pleckstrin domain protein 2 -- ko04015 Rap1 signaling pathway ko04520 Adherens junction Rho guanine nucleotide exchange factor CDEP T Signal transduction mechanisms ; IPR000219 [Dbl homology (DH) domain] ; IPR001849[Pleckstrin homology domain] ; IPR014847[FERM adjacent (FA)] ; IPR018979[FERM, N-terminal] ; IPR018980[FERM, C-terminal PH-like domain] ; IPR019748[FERM central domain] -- -- Q9WV98 Mitochondrial import inner membrane translocase subunit Tim9 Timm9 1117.5 1137.4 1271 1279.2 1316.7 1306.3 0.903567218492133 0.0642943996937673 -0.146296164325392 Nonsignificant None -- -- mitochondrial import inner membrane translocase subunit TIM9 -- -- Mitochondrial import inner membrane translocase, subunit TIM9 U Intracellular trafficking, secretion, and vesicular transport ; IPR004217 [Tim10/DDP family zinc finger] -- -- Q4V9W8 Ras-related protein Rab-4 Rab4b 241.4 225.1 216.8 247.3 283.7 258.2 0.865813482007096 0.053037790726195 -0.207871829248921 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-4B -- -- GTPase Rab4, small G protein superfamily U Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- Q8BGT7 Survival of motor neuron-related-splicing factor 30 Smndc1 917.2 919.2 903.4 1083.6 1125.7 1087.1 0.831149132386846 0.000207740333271055 -0.266820733112604 Nonsignificant None 4 Molecular Function:RNA binding (GO:0003723),Cellular Component:nucleus (GO:0005634),Cellular Component:cytoplasm (GO:0005737),Biological Process:mRNA processing (GO:0006397) survival of motor neuron-related-splicing factor 30 -- ko03040 Spliceosome Splicing factor SPF30 A RNA processing and modification ; IPR010304 [Survival motor neuron] -- -- Q9CPX7 28S ribosomal protein S16, mitochondrial Mrps16 676.7 627.5 680.6 652.5 613.8 622.9 1.05060343002329 0.198514247531131 0.0712181997418656 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S16 -- ko03010 Ribosome Mitochondrial/chloroplast ribosomal protein S16 J Translation, ribosomal structure and biogenesis ; IPR000307 [Ribosomal protein S16] -- -- O35379 Multidrug resistance-associated protein 1 Abcc1 249 232.9 225 247.5 253.9 266 0.921162366432108 0.0862256039756205 -0.118472623043212 Nonsignificant None 5 Molecular Function:ATP binding (GO:0005524),Biological Process:transport (GO:0006810),Cellular Component:integral component of membrane (GO:0016021),Molecular Function:ATPase activity (GO:0016887),Biological Process:transmembrane transport (GO:0055085) ATP-binding cassette, subfamily C (CFTR/MRP), member 1 -- ko01523 Antifolate resistance ko02010 ABC transporters ko04071 Sphingolipid signaling pathway ko04977 Vitamin digestion and absorption ko05206 MicroRNAs in cancer Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Q Secondary metabolites biosynthesis, transport and catabolism ; IPR003439 [ABC transporter-like] ; IPR011527[ABC transporter type 1, transmembrane domain] -- -- Q9DBB4 N-alpha-acetyltransferase 16, NatA auxiliary subunit Naa16 339.7 309.5 283.8 287 396.9 302.7 0.945672004865194 0.662145385917192 -0.0805882062553715 Nonsignificant None -- -- N-alpha-acetyltransferase 15/16, NatA auxiliary subunit -- -- N-terminal acetyltransferase B Chromatin structure and dynamics ; IPR021183 [N-terminal acetyltransferase A, auxiliary subunit] -- -- Q5BLK4 Terminal uridylyltransferase 7 Tut7 151.8 153.1 152.8 148.6 161.9 165 0.962565720294427 0.359395801308782 -0.0550430491472641 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:zinc ion binding (GO:0008270),Molecular Function:nucleotidyltransferase activity (GO:0016779) terminal uridylyltransferase 2.7.7.52 -- S-M checkpoint control protein CID1 and related nucleotidyltransferases D Cell cycle control, cell division, chromosome partitioning ; IPR001878 [Zinc finger, CCHC-type] ; IPR002058[PAP/25A-associated] ; IPR002934[Polymerase, nucleotidyl transferase domain] -- -- A0A1B0GSH8 Predicted gene 45808 (Fragment) Gm45808 192.8 176.4 132.7 184.2 148.3 174.6 0.989745612305265 0.937890927479068 -0.0148703283071262 Nonsignificant None -- -- -- -- ko00040 Pentose and glucuronate interconversions ko00980 Metabolism of xenobiotics by cytochrome P450 Dimeric dihydrodiol dehydrogenase GQ Carbohydrate transport and metabolism ; Secondary metabolites biosynthesis, transport and catabolism ; -- -- -- Q8BGB7 Enolase-phosphatase E1 Enoph1 791.7 765.4 782.5 921.8 917.8 880.3 0.860178683039818 0.0011581917287825 -0.217291716050522 Nonsignificant None -- -- enolase-phosphatase E1 3.1.3.77 ko00270 Cysteine and methionine metabolism ko01100 Metabolic pathways Enolase-phosphatase E-1 E Amino acid transport and metabolism ; -- -- -- Q3UWY4 Calponin-homology (CH) domain-containing protein Lrch1 334.9 352.4 356.6 399.7 419.7 404.5 0.852929160879157 0.00259980207001528 -0.229502169864604 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Leucine-rich repeat (LRR) protein, contains calponin homology domain Z Cytoskeleton ; IPR001611 [Leucine-rich repeat] ; IPR001715[Calponin homology domain] -- -- Q6P3D0 U8 snoRNA-decapping enzyme Nudt16 547 550.3 707.5 744.9 705.5 779.8 0.80925477535647 0.0680989807536549 -0.30533412118412 Nonsignificant None -- -- -- -- ko00230 Purine metabolism ko03018 RNA degradation -- -- -- -- -- -- Q8VCA8 Secernin-2 Scrn2 332.2 338.7 352.5 430.9 398 443.6 0.804243614931238 0.00501618853227127 -0.314295517840379 Nonsignificant None 2 Biological Process:proteolysis (GO:0006508),Molecular Function:dipeptidase activity (GO:0016805) secernin -- -- -- -- -- IPR005322 [Peptidase C69, dipeptidase A] -- -- A0A4E9G461 IgG2 (Fragment) IGHG2 116 96.5 130.8 122.3 108 120.2 0.979457917261056 0.836319451039872 -0.0299445869407288 Nonsignificant None -- -- immunoglobulin lambda-like polypeptide 1 -- -- -- -- -- IPR003597 [Immunoglobulin C1-set] -- -- Q3UDN2 Vacuolar protein sorting-associated protein 53 homolog Vps53 399.1 392.1 408.6 449.4 448.4 426.1 0.906261802250925 0.00999540779485836 -0.142000216527039 Nonsignificant None -- -- vacuolar protein sorting-associated protein 53 -- -- Late Golgi protein sorting complex, subunit Vps53 U Intracellular trafficking, secretion, and vesicular transport ; IPR007234 [Vps53-like, N-terminal] -- -- Q9CQ22 Ragulator complex protein LAMTOR1 Lamtor1 558.2 546.7 628.4 683.6 668.3 652.2 0.864877002145601 0.0290650953871834 -0.20943311937711 Nonsignificant None 10 Biological Process:regulation of receptor recycling (GO:0001919),Biological Process:lysosome organization (GO:0007040),Cellular Component:late endosome membrane (GO:0031902),Biological Process:positive regulation of TOR signaling (GO:0032008),Biological Process:endosome localization (GO:0032439),Biological Process:cholesterol homeostasis (GO:0042632),Biological Process:positive regulation of MAPK cascade (GO:0043410),Cellular Component:membrane raft (GO:0045121),Biological Process:cellular response to amino acid stimulus (GO:0071230),Cellular Component:Ragulator complex (GO:0071986) ragulator complex protein LAMTOR1 -- ko04150 mTOR signaling pathway -- -- -- IPR028209 [LAMTOR1/MEH1] -- -- Q61140 Breast cancer anti-estrogen resistance protein 1 Bcar1 211.9 193.3 201.7 196.4 200 214.7 0.993127147766323 0.86563613448699 -0.00994966040760485 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) breast cancer anti-estrogen resistance 1 -- ko04015 Rap1 signaling pathway ko04062 Chemokine signaling pathway ko04510 Focal adhesion ko04670 Leukocyte transendothelial migration ko04810 Regulation of actin cytoskeleton ko05100 Bacterial invasion of epithelial cells -- -- -- IPR001452 [SH3 domain] ; IPR014928[Serine rich protein interaction] ; IPR021901[CAS family, DUF3513] -- -- Q9R1K9 Centrin-2 Cetn2 1055.2 1022.4 946.3 897.1 939.9 1037.2 1.05208405817271 0.395869083606044 0.0732499759840443 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) centrin-2 -- ko03420 Nucleotide excision repair Ca2+-binding protein (centrin/caltractin), EF-Hand superfamily protein ZD Cytoskeleton ; Cell cycle control, cell division, chromosome partitioning ; IPR002048 [EF-hand domain] -- -- Q9CRA4 Methylsterol monooxygenase 1 Msmo1 552.1 542.4 568.7 663.7 705.8 638.4 0.828328103989243 0.00552640538460801 -0.271725756828083 Nonsignificant None 4 Molecular Function:iron ion binding (GO:0005506),Biological Process:fatty acid biosynthetic process (GO:0006633),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) methylsterol monooxygenase 1.14.18.9 ko00100 Steroid biosynthesis ko01100 Metabolic pathways C-4 sterol methyl oxidase I Lipid transport and metabolism ; IPR006694 [Fatty acid hydroxylase] -- -- Q8K4I3 Rho guanine nucleotide exchange factor 6 Arhgef6 693.3 677.9 611.1 530.2 578.7 571.7 1.17951921932643 0.0268220088288037 0.238198926335773 Nonsignificant None 3 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Molecular Function:protein binding (GO:0005515),Biological Process:regulation of Rho protein signal transduction (GO:0035023) Rho guanine nucleotide exchange factor 6 -- ko04810 Regulation of actin cytoskeleton ko05212 Pancreatic cancer Guanine nucleotide exchange factor F Nucleotide transport and metabolism ; IPR000219 [Dbl homology (DH) domain] ; IPR001452[SH3 domain] ; IPR001715[Calponin homology domain] ; IPR001849[Pleckstrin homology domain] ; IPR032409[Rho guanine nucleotide exchange factor, coiled-coil domain] -- -- E9PWF0 Thrombospondin-3 Thbs3 48 46 56 58.2 63.1 49 0.880798590722255 0.258341425306083 -0.183115934295299 Nonsignificant None 3 Molecular Function:calcium ion binding (GO:0005509),Cellular Component:extracellular region (GO:0005576),Biological Process:cell adhesion (GO:0007155) thrombospondin 2/3/4/5 -- ko04145 Phagosome ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko05144 Malaria ko05165 Human papillomavirus infection -- -- -- IPR001881 [EGF-like calcium-binding domain] ; IPR003367[Thrombospondin, type 3-like repeat] ; IPR008859[Thrombospondin, C-terminal] ; IPR024665[Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain] -- -- G5E8H0 Villin-like protein Vill 487.1 567.5 568.5 526.9 530.5 497 1.04419711785898 0.473663868799422 0.0623940817487812 Nonsignificant None 2 Molecular Function:actin binding (GO:0003779),Biological Process:cytoskeleton organization (GO:0007010) -- -- -- Actin regulatory proteins (gelsolin/villin family) Z Cytoskeleton ; IPR003128 [Villin headpiece] ; IPR007123[Gelsolin-like domain] -- -- Q8BKZ9 Pyruvate dehydrogenase protein X component, mitochondrial Pdhx 667.2 649.3 832 895.5 874 863.1 0.816113348020968 0.0519743912106889 -0.293158556328693 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex -- ko01100 Metabolic pathways Dihydrolipoamide acetyltransferase C Energy production and conversion ; IPR000089 [Biotin/lipoyl attachment] ; IPR001078[2-oxoacid dehydrogenase acyltransferase, catalytic domain] ; IPR004167[E3-binding domain] -- -- Q8CIH5 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Plcg2 526.7 542.8 487.1 489.7 528.3 497.1 1.02739093129166 0.533793737385482 0.0389852442848697 Nonsignificant None 5 Molecular Function:phosphatidylinositol phospholipase C activity (GO:0004435),Molecular Function:protein binding (GO:0005515),Biological Process:lipid metabolic process (GO:0006629),Biological Process:signal transduction (GO:0007165),Biological Process:intracellular signal transduction (GO:0035556) phosphatidylinositol phospholipase C, gamma-2 3.1.4.11 ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko01521 EGFR tyrosine kinase inhibitor resistance ko04012 ErbB signaling pathway ko04014 Ras signaling pathway ko04020 Calcium signaling pathway ko04064 NF-kappa B signaling pathway ko04066 HIF-1 signaling pathway ko04070 Phosphatidylinositol signaling system ko04072 Phospholipase D signaling pathway ko04360 Axon guidance ko04370 VEGF signaling pathway ko04380 Osteoclast differentiation ko04611 Platelet activation ko04650 Natural killer cell mediated cytotoxicity ko04662 B cell receptor signaling pathway ko04664 Fc epsilon RI signaling pathway ko04666 Fc gamma R-mediated phagocytosis ko04670 Leukocyte transendothelial migration ko04722 Neurotrophin signaling pathway ko04750 Inflammatory mediator regulation of TRP channels ko04919 Thyroid hormone signaling pathway ko04933 AGE-RAGE signaling pathway in diabetic complications ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05206 MicroRNAs in cancer ko05214 Glioma ko05223 Non-small cell lung cancer ko05225 Hepatocellular carcinoma Phospholipase C I Lipid transport and metabolism ; IPR000008 [C2 domain] ; IPR000909[Phosphatidylinositol-specific phospholipase C, X domain] ; IPR000980[SH2 domain] ; IPR001452[SH3 domain] ; IPR001711[Phospholipase C, phosphatidylinositol-specific, Y domain] -- -- P55050 Fatty acid-binding protein, intestinal Fabp2 1174.7 1210.4 2310.4 3549.5 1579.7 2147.9 0.645243297467398 0.28273801599021 -0.632084844636725 Nonsignificant None -- -- fatty acid-binding protein 2, intestinal -- ko03320 PPAR signaling pathway ko04975 Fat digestion and absorption Fatty acid-binding protein FABP I Lipid transport and metabolism ; IPR000566 [Lipocalin/cytosolic fatty-acid binding domain] -- -- Q9WUH1 Transmembrane protein 115 Tmem115 290.6 293.9 249.5 301.8 317.8 270.2 0.937289278489548 0.404770409849506 -0.0934337148437608 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) -- -- -- Predicted membrane protein S Function unknown ; IPR013861 [Transmembrane protein DUF1751, eukaryotic] -- -- Q64314 Hematopoietic progenitor cell antigen CD34 Cd34 1476.6 1447.5 1378.7 1596.1 1671.3 1673.2 0.870906367647654 0.00528266183561762 -0.199410473872192 Nonsignificant None -- -- CD34 antigen -- ko04514 Cell adhesion molecules (CAMs) ko04640 Hematopoietic cell lineage -- -- -- IPR013836 [CD34/Podocalyxin] -- -- Q91WQ9 Calmodulin-like protein 4 Calml4 890.9 845.4 885.5 941.3 896.8 954.1 0.938972852947497 0.0652620647104131 -0.0908446467891145 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) calmodulin -- ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04070 Phosphatidylinositol signaling system ko04114 Oocyte meiosis ko04218 Cellular senescence ko04261 Adrenergic signaling in cardiomyocytes ko04270 Vascular smooth muscle contraction ko04371 Apelin signaling pathway ko04713 Circadian entrainment ko04720 Long-term potentiation ko04722 Neurotrophin signaling pathway ko04728 Dopaminergic synapse ko04740 Olfactory transduction ko04744 Phototransduction ko04750 Inflammatory mediator regulation of TRP channels ko04910 Insulin signaling pathway ko04912 GnRH signaling pathway ko04915 Estrogen signaling pathway ko04916 Melanogenesis ko04921 Oxytocin signaling pathway ko04922 Glucagon signaling pathway ko04924 Renin secretion ko04925 Aldosterone synthesis and secretion ko04970 Salivary secretion ko04971 Gastric acid secretion ko05010 Alzheimer's disease ko05031 Amphetamine addiction ko05034 Alcoholism ko05133 Pertussis ko05152 Tuberculosis ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05200 Pathways in cancer ko05214 Glioma ko05418 Fluid shear stress and atherosclerosis Calmodulin and related proteins (EF-Hand superfamily) T Signal transduction mechanisms ; IPR002048 [EF-hand domain] -- -- P07607 Thymidylate synthase Tyms 275.3 287 282.2 241 258.5 255.2 1.11898767722274 0.00922438337431713 0.162194148818743 Nonsignificant None -- -- thymidylate synthase 2.1.1.45 ko00240 Pyrimidine metabolism ko00670 One carbon pool by folate ko01100 Metabolic pathways ko01523 Antifolate resistance Thymidylate synthase F Nucleotide transport and metabolism ; IPR023451 [Thymidylate synthase/dCMP hydroxymethylase domain] -- -- J3KMT7 Transducin-like enhancer protein 3 Tle3 10.3 10.4 8.2 7.3 8.5 11.7 1.05090909090909 0.770710577622892 0.071637874088657 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Transducin-like enhancer of split protein (contains WD40 repeats) B Chromatin structure and dynamics ; IPR001680 [WD40 repeat] ; IPR005617[Groucho/TLE, N-terminal Q-rich domain] -- -- Q6A0A2 La-related protein 4B Larp4b 442.3 418.2 457.7 417.4 439.4 410.4 1.04024621212121 0.304291617764355 0.0569250350648231 Nonsignificant None -- -- la-related protein 4 -- -- c-Mpl binding protein, contains La domain T Signal transduction mechanisms ; IPR006630 [RNA-binding protein Lupus La] -- -- A0A494B9Y9 Zinc finger protein-like 1 Zfpl1 478.8 507.6 513 587 562.5 531 0.892234454031538 0.0356723300098235 -0.164505235387504 Nonsignificant None -- -- -- -- -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; -- -- -- Q8BIJ7 RUN and FYVE domain-containing protein 1 Rufy1 721.6 737.3 822.6 815.3 822.1 831.6 0.924058323207776 0.182153789690081 -0.113944182697129 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) RUN and FYVE domain-containing protein 1 -- ko04144 Endocytosis FYVE finger containing protein R General function prediction only ; IPR000306 [FYVE zinc finger] ; IPR004012[RUN domain] -- -- Q9D820 Prolyl-tRNA synthetase associated domain-containing protein 1 Prorsd1 591.3 596.9 635.5 649.7 653.4 646 0.935662613513929 0.0917230302595725 -0.0959396863997738 Nonsignificant None 1 Molecular Function:aminoacyl-tRNA editing activity (GO:0002161) -- -- -- -- -- -- IPR007214 [YbaK/aminoacyl-tRNA synthetase-associated domain] -- -- Q8QZY7 Neuropilin Nrp2 361.4 348.8 307.2 341.7 347 330.9 0.997842291094547 0.967748987847386 -0.00311627915957309 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) neuropilin 2 -- -- -- -- -- IPR000421 [Coagulation factor 5/8 C-terminal domain] ; IPR000859[CUB domain] ; IPR000998[MAM domain] ; IPR022579[Neuropilin, C-terminal] -- -- Q9JI46 Diphosphoinositol polyphosphate phosphohydrolase 1 Nudt3 77 88.6 89.6 82 88.7 90.6 0.97665518561041 0.694339899967921 -0.0340787955551513 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) diphosphoinositol-polyphosphate diphosphatase 3.6.1.52 -- Diadenosine and diphosphoinositol polyphosphate phosphohydrolase T Signal transduction mechanisms ; IPR000086 [NUDIX hydrolase domain] -- -- Q9JHK4 Geranylgeranyl transferase type-2 subunit alpha Rabggta 292.8 294.2 324.8 343.8 329.2 302.7 0.934508557958389 0.252128007208672 -0.0977202190735961 Nonsignificant None 4 Molecular Function:Rab geranylgeranyltransferase activity (GO:0004663),Molecular Function:zinc ion binding (GO:0008270),Molecular Function:protein prenyltransferase activity (GO:0008318),Biological Process:protein prenylation (GO:0018342) geranylgeranyl transferase type-2 subunit alpha 2.5.1.60 -- Protein geranylgeranyltransferase type II, alpha subunit O Posttranslational modification, protein turnover, chaperones ; IPR002088 [Protein prenyltransferase, alpha subunit] ; IPR009087[Rab geranylgeranyltransferase, alpha subunit, insert-domain] -- -- Q00558 40-kDa huntingtin-associated protein F8a1 382.6 328 362.4 334 350.9 380.8 1.00684995777423 0.913361457470606 0.00984870687676067 Nonsignificant None -- -- factor VIII intron 22 protein -- -- -- -- -- -- -- -- Q6ZQC2 MKIAA0410 protein (Fragment) mKIAA0410 445 390.9 434.9 435.6 442.5 477.4 0.93751383253412 0.250976582138598 -0.0930881180115815 Nonsignificant None -- -- nucleoporin p58/p45 -- ko03013 RNA transport -- -- -- -- -- -- E9Q8A3 Phosphatidylinositol 4-kinase beta Pi4kb 421.6 382.3 396.2 421.7 426.9 394.3 0.965564405825087 0.404380858820519 -0.0505556007394587 Nonsignificant None 1 Molecular Function:kinase activity (GO:0016301) phosphatidylinositol 4-kinase B 2.7.1.67 ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system Phosphatidylinositol 4-kinase, involved in intracellular trafficking and secretion TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR000403 [Phosphatidylinositol 3-/4-kinase, catalytic domain] -- -- Q9D1H7 Golgi to ER traffic protein 4 homolog Get4 479.3 488.9 492.4 498.6 460.2 508.9 0.995162499148327 0.884761020498963 -0.00699597367939419 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR007317 [Uncharacterised protein family UPF0363] -- -- Q8K2L8 Trafficking protein particle complex subunit 12 Trappc12 285.4 259.5 289.9 308.8 276.9 288.9 0.954493482734965 0.374223251918367 -0.0671927479213725 Nonsignificant None -- -- trafficking protein particle complex subunit 12 -- -- Uncharacterized conserved protein S Function unknown ; -- -- -- P17665 Cytochrome c oxidase subunit 7C, mitochondrial Cox7c 1284.6 1356.2 1751 1822.4 1795.7 1733.1 0.820713111077889 0.0958663159924947 -0.285050094025766 Nonsignificant None 1 Molecular Function:cytochrome-c oxidase activity (GO:0004129) cytochrome c oxidase subunit 7c -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04260 Cardiac muscle contraction ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Cytochrome c oxidase, subunit VIIc/COX8 C Energy production and conversion ; IPR004202 [Cytochrome c oxidase subunit VIIc] -- -- P63213 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Gng2 328.1 360.7 375.3 413.4 399.3 424 0.860435028705426 0.0214019447363999 -0.216861836152742 Nonsignificant None 3 Molecular Function:signal transducer activity (GO:0004871),Cellular Component:heterotrimeric G-protein complex (GO:0005834),Biological Process:G-protein coupled receptor signaling pathway (GO:0007186) guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 -- ko04014 Ras signaling pathway ko04062 Chemokine signaling pathway ko04151 PI3K-Akt signaling pathway ko04371 Apelin signaling pathway ko04713 Circadian entrainment ko04723 Retrograde endocannabinoid signaling ko04724 Glutamatergic synapse ko04725 Cholinergic synapse ko04726 Serotonergic synapse ko04727 GABAergic synapse ko04728 Dopaminergic synapse ko04926 Relaxin signaling pathway ko05032 Morphine addiction ko05034 Alcoholism ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05200 Pathways in cancer G protein gamma subunit T Signal transduction mechanisms ; IPR015898 [G-protein gamma-like domain] -- -- Q03963 Interferon-induced, double-stranded RNA-activated protein kinase Eif2ak2 904.7 917.2 939.4 871.1 959.6 923.4 1.00261428415816 0.934931201705558 0.00376669332959149 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) eukaryotic translation initiation factor 2-alpha kinase 2 2.7.11.1 ko04141 Protein processing in endoplasmic reticulum ko04217 Necroptosis ko05160 Hepatitis C ko05162 Measles ko05164 Influenza A ko05165 Human papillomavirus infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis eIF-2alpha kinase PEK/EIF2AK3 J Translation, ribosomal structure and biogenesis ; IPR000719 [Protein kinase domain] ; IPR014720[Double-stranded RNA-binding domain] -- -- Q99KL9 Replication protein A2 Rpa2 100.9 98.1 92.6 83.6 80.2 64.8 1.2755905511811 0.0286827397201211 0.351165316112459 Nonsignificant None -- -- replication factor A2 -- ko03030 DNA replication ko03420 Nucleotide excision repair ko03430 Mismatch repair ko03440 Homologous recombination ko03460 Fanconi anemia pathway Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit L Replication, recombination and repair ; IPR014892 [Replication protein A, C-terminal] -- -- Q8VEE0 Ribulose-phosphate 3-epimerase Rpe 246.5 252.1 185.5 203.5 202.4 190.3 1.14743374706474 0.249070961874894 0.198410854693057 Nonsignificant None 1 Biological Process:carbohydrate metabolic process (GO:0005975) ribulose-phosphate 3-epimerase 5.1.3.1 ko00030 Pentose phosphate pathway ko00040 Pentose and glucuronate interconversions ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids D-ribulose-5-phosphate 3-epimerase G Carbohydrate transport and metabolism ; IPR000056 [Ribulose-phosphate 3-epimerase-like] -- -- Q63ZW6 Col4a5 protein Col4a5 629.6 624.3 730.3 711.7 739.1 785.1 0.887427881390044 0.107606750195174 -0.172298214130336 Nonsignificant None 2 Molecular Function:extracellular matrix structural constituent (GO:0005201),Cellular Component:collagen trimer (GO:0005581) collagen, type IV, alpha -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04926 Relaxin signaling pathway ko04933 AGE-RAGE signaling pathway in diabetic complications ko04974 Protein digestion and absorption ko05146 Amoebiasis ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05222 Small cell lung cancer Collagens (type IV and type XIII), and related proteins W Extracellular structures ; IPR001442 [Collagen IV, non-collagenous] ; IPR008160[Collagen triple helix repeat] -- -- A0A0R4J257 Protein unc-13 homolog D Unc13d 140.4 130.5 133.5 135.8 122.2 140.1 1.01582516955539 0.749530712759866 0.0226521258116655 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) protein unc-13 D -- -- Synaptic vesicle protein BAIAP3, involved in vesicle priming/regulation UT Intracellular trafficking, secretion, and vesicular transport ; Signal transduction mechanisms ; IPR000008 [C2 domain] -- -- Q9DCG9 Multifunctional methyltransferase subunit TRM112-like protein Trmt112 444.7 445.1 464.9 436.6 441.2 442.7 1.02589928057554 0.174606304745107 0.0368890988330183 Nonsignificant None -- -- multifunctional methyltransferase subunit TRM112 -- -- Uncharacterized conserved protein S Function unknown ; IPR005651 [Uncharacterised protein family UPF0434/Trm112] -- -- Q8BH15 CCR4-NOT transcription complex subunit 10 Cnot10 341.9 351.6 420.9 388.1 381.1 392.3 0.959448988377098 0.593476260383852 -0.0597219910949172 Nonsignificant None -- -- CCR4-NOT transcription complex subunit 10 -- ko03018 RNA degradation TPR repeat-containing protein R General function prediction only ; -- -- -- Q9JHH9 Coatomer subunit zeta-2 Copz2 672.4 669.6 792.4 741 718.2 703.5 0.986914505016877 0.832979984934704 -0.0190029833875935 Nonsignificant None -- -- coatomer subunit zeta -- -- Vesicle coat complex COPI, zeta subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR022775 [AP complex, mu/sigma subunit] -- -- Q9Z1E4 Glycogen [starch] synthase, muscle Gys1 603.7 550 576.2 532 503.4 550.7 1.09066263161213 0.0817761072257784 0.125204910122132 Nonsignificant None 2 Molecular Function:glycogen (starch) synthase activity (GO:0004373),Biological Process:glycogen biosynthetic process (GO:0005978) glycogen synthase 2.4.1.11 ko00500 Starch and sucrose metabolism ko01100 Metabolic pathways ko04151 PI3K-Akt signaling pathway ko04152 AMPK signaling pathway ko04910 Insulin signaling pathway ko04922 Glucagon signaling pathway ko04931 Insulin resistance Glycogen synthase G Carbohydrate transport and metabolism ; IPR008631 [Glycogen synthase] -- -- P15920 V-type proton ATPase 116 kDa subunit a 2 Atp6v0a2 399.7 406.2 390.7 444.7 462.6 449.9 0.88166814028883 0.00153795851413242 -0.181692367056021 Nonsignificant None 2 Molecular Function:hydrogen ion transmembrane transporter activity (GO:0015078),Biological Process:ATP hydrolysis coupled proton transport (GO:0015991) V-type H+-transporting ATPase subunit a -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04142 Lysosome ko04145 Phagosome ko04721 Synaptic vesicle cycle ko04966 Collecting duct acid secretion ko05152 Tuberculosis ko05165 Human papillomavirus infection ko05323 Rheumatoid arthritis Vacuolar H+-ATPase V0 sector, subunit a C Energy production and conversion ; IPR002490 [V-type ATPase, V0 complex, 116kDa subunit family] -- -- Q9CQN7 39S ribosomal protein L41, mitochondrial Mrpl41 1396.4 1324.9 1440 1332.5 1384.4 1394.6 1.012112367749 0.689828059992284 0.0173694712523796 Nonsignificant None -- -- large subunit ribosomal protein L41 -- -- Mitochondrial ribosomal protein L27 J Translation, ribosomal structure and biogenesis ; IPR019189 [Ribosomal protein L27/L41, mitochondrial] -- -- Q3TR43 Dipeptidyl peptidase 4 Dpp4 356.8 335.5 393.4 455.5 447.7 436.3 0.810526315789474 0.00895781875549364 -0.303069067636047 Nonsignificant None 2 Biological Process:proteolysis (GO:0006508),Molecular Function:serine-type peptidase activity (GO:0008236) dipeptidyl-peptidase 4 3.4.14.5 ko04974 Protein digestion and absorption Dipeptidyl aminopeptidase O Posttranslational modification, protein turnover, chaperones ; IPR001375 [Peptidase S9, prolyl oligopeptidase, catalytic domain] ; IPR002469[Dipeptidylpeptidase IV, N-terminal domain] -- -- Q6PGC1 ATP-dependent RNA helicase DHX29 Dhx29 426 380.2 363.2 358 362.1 361.2 1.08147600110978 0.257531733727985 0.113001651001168 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:helicase activity (GO:0004386),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase DHX29 3.6.4.13 -- ATP-dependent RNA helicase A A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR007502[Helicase-associated domain] ; IPR011545[DEAD/DEAH box helicase domain] ; IPR011709[Domain of unknown function DUF1605] -- -- Q9CXN7 Phenazine biosynthesis-like domain-containing protein 2 Pbld2 297.2 300.8 361 528.6 527.7 552 0.59628178822359 0.000616667854702012 -0.74593382057831 Significant down 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:biosynthetic process (GO:0009058) -- -- -- Predicted PhzC/PhzF-type epimerase R General function prediction only ; IPR003719 [Phenazine biosynthesis PhzF protein] -- -- Q9QY81 Nuclear pore membrane glycoprotein 210 Nup210 738.7 685.4 719.3 732.3 673.1 713.5 1.01156260323753 0.744691964046109 0.0165856076722747 Nonsignificant None -- -- nuclear pore complex protein Nup210 -- ko03013 RNA transport Nuclear pore complex, gp210 component YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; IPR003343 [Bacterial Ig-like, group 2] -- -- Q9CPQ1 Cytochrome c oxidase subunit 6C Cox6c 2543.1 2358.7 3203.9 3574.1 3380.1 3541.3 0.772302415320852 0.0390394297656972 -0.372762211575982 Nonsignificant None -- -- cytochrome c oxidase subunit 6c -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04260 Cardiac muscle contraction ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease -- -- -- -- -- -- A0A494BBA2 Steroid receptor RNA activator 1 (Fragment) Sra1 776.9 822 836.4 855.8 838.7 737.6 1.00131573537272 0.980493288273852 0.00189695722397119 Nonsignificant None -- -- -- -- -- Vesicle coat complex COPII, subunit SEC31 U Intracellular trafficking, secretion, and vesicular transport ; IPR009917 [Steroid receptor RNA activator-protein/coat protein complex II, Sec31] -- -- P14069 Protein S100-A6 S100a6 4606.7 4446.8 5660.5 7585.1 6581.6 7530.4 0.678155145157648 0.00969460083355043 -0.560312730752085 Nonsignificant None -- -- -- -- -- -- -- -- IPR013787 [S100/CaBP-9k-type, calcium binding, subdomain] -- -- Q8BX12 Uncharacterized protein (Fragment) Ncoa5 687.7 717.6 645.9 623.8 619.7 646.3 1.08540586305429 0.0740100309832734 0.11823460684298 Nonsignificant None -- -- -- -- -- Nuclear pore complex, Nup98 component (sc Nup145/Nup100/Nup116) YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; -- -- -- P05533 Lymphocyte antigen 6A-2/6E-1 Ly6a 394.1 411.2 270.9 215.1 228.7 215 1.63357619914997 0.0862848098817335 0.708033751728419 Nonsignificant None -- -- lymphocyte antigen 6 complex locus protein D/E/G6/H -- -- -- -- -- IPR016054 [Ly-6 antigen/uPA receptor-like] -- -- Q62395 Trefoil factor 3 Tff3 901.9 968.8 1302.3 1144.2 1473.5 1304.3 0.809026007139215 0.185022044348526 -0.305742014274511 Nonsignificant None -- -- -- -- -- IPR000519 [P-type trefoil domain] -- -- A0A087WQK5 alpha-1,2-Mannosidase Edem3 210.2 176.4 190.7 180.3 208.3 181.1 1.01334035457258 0.859673115136918 0.0191188191371312 Nonsignificant None 3 Molecular Function:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity (GO:0004571),Molecular Function:calcium ion binding (GO:0005509),Cellular Component:membrane (GO:0016020) ER degradation enhancer, mannosidase alpha-like 3 -- ko04141 Protein processing in endoplasmic reticulum Glycosyl hydrolase, family 47 G Carbohydrate transport and metabolism ; IPR001382 [Glycoside hydrolase family 47] ; IPR003137[PA domain] -- -- A2AT37 Regulator of nonsense transcripts 2 Upf2 239.7 266.9 255.8 235.3 235.5 246 1.06361607142857 0.153741344399888 0.0889774818523378 Nonsignificant None 2 Molecular Function:RNA binding (GO:0003723),Molecular Function:protein binding (GO:0005515) regulator of nonsense transcripts 2 -- ko03013 RNA transport ko03015 mRNA surveillance pathway Nonsense-mediated mRNA decay 2 protein A RNA processing and modification ; IPR003890 [MIF4G-like, type 3] ; IPR007193[Up-frameshift suppressor 2] -- -- A0A0A0MQL2 RIKEN cDNA A430005L14 gene (Fragment) A430005L14Rik 242.9 237.3 203.3 238.5 266.8 224.2 0.936943111720356 0.432804714241316 -0.0939666403118308 Nonsignificant None -- -- -- -- -- -- -- -- IPR031530 [UPF0688 family] -- -- D6RGM8 Transmembrane 9 superfamily member Tm9sf1 344.5 334.7 402 388.7 366.2 373 0.958595620179094 0.518676944479043 -0.0610057465853337 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) transmembrane 9 superfamily member 1 -- -- Endosomal membrane proteins, EMP70 U Intracellular trafficking, secretion, and vesicular transport ; IPR004240 [Nonaspanin (TM9SF)] -- -- Q8C4X2 Casein kinase I isoform gamma-3 Csnk1g3 497 465.6 536.9 532.6 550.9 547.2 0.919543754215981 0.110179430650049 -0.121009871540427 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) casein kinase 1, gamma 2.7.11.1 ko04340 Hedgehog signaling pathway Casein kinase (serine/threonine/tyrosine protein kinase) T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR022247[Casein kinase 1 gamma C-terminal] -- -- Q3U487 E3 ubiquitin-protein ligase HECTD3 Hectd3 688.5 660.3 681.4 690.2 706.6 640.8 0.996368276403612 0.914236392020328 -0.00524900687322633 Nonsignificant None 1 Molecular Function:ubiquitin-protein transferase activity (GO:0004842) E3 ubiquitin-protein ligase HECTD3 2.3.2.26 -- E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein OK Posttranslational modification, protein turnover, chaperones ; Transcription ; IPR000569 [HECT domain] ; IPR004939[APC10/DOC domain] -- -- Q8CF89 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Tab1 224.8 232.8 236 221 211.6 236.9 1.03599701269604 0.377441792568444 0.0510198430101624 Nonsignificant None 1 Molecular Function:catalytic activity (GO:0003824) TAK1-binding protein 1 -- ko04010 MAPK signaling pathway ko04064 NF-kappa B signaling pathway ko04380 Osteoclast differentiation ko04620 Toll-like receptor signaling pathway ko04621 NOD-like receptor signaling pathway ko04668 TNF signaling pathway ko05140 Leishmaniasis ko05145 Toxoplasmosis ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection Serine/threonine protein phosphatase T Signal transduction mechanisms ; IPR001932 [PPM-type phosphatase domain] -- -- A0A5H1ZRL3 Negative elongation factor B Nelfb 604 607.5 617.9 590.6 621 618.1 0.999836038694868 0.992889344685115 -0.000236565556140412 Nonsignificant None 1 Cellular Component:nucleus (GO:0005634) negative elongation factor B -- -- -- -- -- IPR010405 [Cofactor of BRCA1] -- -- Q8R378 Leucine-rich repeat protein SHOC-2 Shoc2 540.6 533.8 528.9 537.3 535.3 528.3 1.00149915672434 0.863138262579447 0.00216120638265127 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) leucine-rich repeat protein SHOC2 -- ko04014 Ras signaling pathway FOG: Leucine rich repeat R General function prediction only ; IPR001611 [Leucine-rich repeat] -- -- Q91YD9 Actin nucleation-promoting factor WASL Wasl 1046 1017.5 1014.1 1090.9 1172.3 1105.9 0.913478377014633 0.0227257134027919 -0.130557515725861 Nonsignificant None 1 Molecular Function:actin binding (GO:0003779) Wiskott-Aldrich syndrome protein -- ko04062 Chemokine signaling pathway ko04144 Endocytosis ko04520 Adherens junction ko04530 Tight junction ko04666 Fc gamma R-mediated phagocytosis ko04810 Regulation of actin cytoskeleton ko05100 Bacterial invasion of epithelial cells ko05132 Salmonella infection ko05231 Choline metabolism in cancer Actin regulatory protein (Wiskott-Aldrich syndrome protein) TZ Signal transduction mechanisms ; Cytoskeleton ; IPR000095 [CRIB domain] ; IPR000697[WH1/EVH1 domain] ; IPR003124[WH2 domain] -- -- Q3TQ29 Pumilio homolog 2 Pum2 217.5 222.3 236.6 203.5 205.5 195 1.11986754966887 0.021412881001888 0.163328110197542 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) pumilio RNA-binding family -- -- Translational repressor Pumilio/PUF3 and related RNA-binding proteins (Puf superfamily) J Translation, ribosomal structure and biogenesis ; IPR001313 [Pumilio RNA-binding repeat] -- -- Q78P92 FSHD Region Gene 1 protein Frg1 546.9 558.4 541.5 535.7 533.6 511.7 1.0416192283365 0.074594037588034 0.058827986075536 Nonsignificant None -- -- protein FRG1 -- -- Predicted actin-bundling protein Z Cytoskeleton ; IPR010414 [Protein FRG1] -- -- A0A1D5RMF7 Beta-1,4-N-acetylgalactosaminyltransferase B4galnt3 573.2 614.7 516.3 726.2 814.8 757 0.741601392515231 0.00683193019405771 -0.431284141952867 Nonsignificant None 2 Molecular Function:acetylgalactosaminyltransferase activity (GO:0008376),Cellular Component:Golgi cisterna membrane (GO:0032580) beta-1,4-N-acetylgalactosaminyltransferase 3 2.4.1.244 ko01100 Metabolic pathways -- -- -- IPR008428 [Chondroitin N-acetylgalactosaminyltransferase] ; IPR011658[PA14 domain] -- -- Q05D14 Clmn protein (Fragment) Clmn 802.9 810.6 898.4 902.6 973.4 935.5 0.893437666725947 0.0534626582588549 -0.162561015919787 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Dystonin, GAS (Growth-arrest-specific protein), and related proteins Z Cytoskeleton ; IPR001715 [Calponin homology domain] -- -- A0A077K846 GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase Alg11 451.2 444.5 494.8 480.5 478.4 465.7 0.976063456408817 0.527175543656358 -0.0349531507156417 Nonsignificant None -- -- alpha-1,2-mannosyltransferase 2.4.1.131 ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways Glycosyltransferase M Cell wall/membrane/envelope biogenesis ; IPR001296 [Glycosyl transferase, family 1] ; IPR031814[ALG11 mannosyltransferase, N-terminal] -- -- E9Q9M1 Cytosolic purine 5-nucleotidase Nt5c2 614 581.7 613.5 520.6 505.1 514.9 1.17434765675711 0.0015186045967317 0.231859570654236 Nonsignificant None -- -- 5'-nucleotidase 3.1.3.5 ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko00760 Nicotinate and nicotinamide metabolism ko01100 Metabolic pathways IMP-GMP specific 5'-nucleotidase F Nucleotide transport and metabolism ; IPR008380 [HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase] -- -- Q9Z0T9 Integrin beta-6 Itgb6 826.4 817.7 753.9 742.1 802.8 699.1 1.06862745098039 0.245780652944279 0.0957589828054307 Nonsignificant None -- -- integrin beta 6 -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04810 Regulation of actin cytoskeleton ko05165 Human papillomavirus infection ko05410 Hypertrophic cardiomyopathy (HCM) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05414 Dilated cardiomyopathy (DCM) Integrin beta subunit (N-terminal portion of extracellular region) TW Signal transduction mechanisms ; Extracellular structures ; IPR002369 [Integrin beta subunit, VWA domain] ; IPR012896[Integrin beta subunit, tail] ; IPR014836[Integrin beta subunit, cytoplasmic domain] ; IPR033760[Integrin beta N-terminal] -- -- Q9Z2X2 26S proteasome non-ATPase regulatory subunit 10 Psmd10 1242.4 1228.4 1210 1185.7 1241.8 1292.9 0.98935598322761 0.704122311716604 -0.0154383799388875 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) 26S proteasome non-ATPase regulatory subunit 10 -- -- 26S proteasome regulatory complex, subunit PSMD10 O Posttranslational modification, protein turnover, chaperones ; IPR002110 [Ankyrin repeat] ; IPR020683[Ankyrin repeat-containing domain] -- -- A2AE27 AMP deaminase Ampd2 818.6 852.7 990.8 905.3 852.5 887.8 1.00623677048685 0.925003049913423 0.00896981549708039 Nonsignificant None 1 Molecular Function:deaminase activity (GO:0019239) AMP deaminase 3.5.4.6 ko00230 Purine metabolism ko01100 Metabolic pathways Adenosine monophosphate deaminase F Nucleotide transport and metabolism ; IPR001365 [Adenosine/AMP deaminase domain] -- -- A2A7Z4 Transcription factor BTF3 Btf3l4 748.2 717.2 1238.3 1140 1138.8 1118.6 0.79581444634132 0.304103113039802 -0.329496006516919 Nonsignificant None -- -- nascent polypeptide-associated complex subunit beta -- RNA polymerase II general transcription factor BTF3 and related proteins K Transcription ; IPR002715 [Nascent polypeptide-associated complex NAC domain] -- -- A6H5Y3 Methionine synthase Mtr 357 362.2 303.1 333.4 330.1 346.3 1.01237868884928 0.841480383154177 0.0177490433247012 Nonsignificant None 6 Cellular Component:intracellular (GO:0005622),Molecular Function:methionine synthase activity (GO:0008705),Biological Process:methionine biosynthetic process (GO:0009086),Molecular Function:cobalamin binding (GO:0031419),Biological Process:pteridine-containing compound metabolic process (GO:0042558),Molecular Function:metal ion binding (GO:0046872) 5-methyltetrahydrofolate--homocysteine methyltransferase 2.1.1.13 ko00270 Cysteine and methionine metabolism ko00450 Selenocompound metabolism ko00670 One carbon pool by folate ko01100 Metabolic pathways ko01230 Biosynthesis of amino acids -- -- -- IPR000489 [Pterin-binding domain] ; IPR003726[Homocysteine-binding domain] ; IPR003759[Cobalamin (vitamin B12)-binding module, cap domain] ; IPR004223[Vitamin B12-dependent methionine synthase, activation domain] ; IPR006158[Cobalamin (vitamin B12)-binding domain] -- -- Q4VA90 Small monomeric GTPase Rab27b 327.7 333.1 461.3 553 511.5 492.1 0.720865989978158 0.0373748151579238 -0.472197009573151 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-27B -- ko04972 Pancreatic secretion GTPase Rab27, small G protein superfamily U Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- Q9D1L9 Ragulator complex protein LAMTOR5 Lamtor5 267 284.2 254.1 310 301.4 296.3 0.887187396716977 0.0236128623309156 -0.172689224003459 Nonsignificant None 5 Cellular Component:cytoplasm (GO:0005737),Biological Process:viral genome replication (GO:0019079),Biological Process:negative regulation of apoptotic process (GO:0043066),Biological Process:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043154),Cellular Component:Ragulator complex (GO:0071986) ragulator complex protein LAMTOR5 -- ko04150 mTOR signaling pathway ko05161 Hepatitis B -- -- -- IPR024135 [Ragulator complex protein LAMTOR5] -- -- Q9D8B4 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 Ndufa11 710.8 403.3 502.2 747.8 775.2 696.3 0.728292704906953 0.0981004896244381 -0.457409700717236 Nonsignificant None -- -- NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 11 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease -- -- -- IPR003397 [Mitochondrial inner membrane translocase subunit Tim17/Tim22/Tim23/peroxisomal protein PMP24] -- -- Q3U5Y4 Anaphase-promoting complex subunit 5 Anapc5 350.7 336.2 305 302.9 334 318.1 1.0386387434555 0.489951370545528 0.0546939471651492 Nonsignificant None -- -- anaphase-promoting complex subunit 5 -- ko04110 Cell cycle ko04114 Oocyte meiosis ko04120 Ubiquitin mediated proteolysis ko04657 IL-17 signaling pathway ko04914 Progesterone-mediated oocyte maturation ko05166 HTLV-I infection Anaphase-promoting complex (APC), subunit 5 DO Cell cycle control, cell division, chromosome partitioning ; Posttranslational modification, protein turnover, chaperones ; IPR026000 [Anaphase-promoting complex subunit 5] -- -- Q9JIX0 Transcription and mRNA export factor ENY2 Eny2 1895.3 1964.9 1513.1 1331.9 1315.1 1427 1.31892488954345 0.0402162757505793 0.399362407979428 Nonsignificant None -- -- enhancer of yellow 2 transcription factor -- -- Transcription factor e(y)2 K Transcription ; -- -- -- Q6KAM0 MFLJ00394 protein (Fragment) Ubxn6 410.1 416.3 439.1 457.1 430 446 0.949291125947041 0.12917654225083 -0.0750774981042456 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) UBX domain-containing protein 6 -- ko04141 Protein processing in endoplasmic reticulum Predicted ubiquitin regulatory protein O Posttranslational modification, protein turnover, chaperones ; IPR001012 [UBX domain] ; IPR018997[PUB domain] -- -- B0FTY3 NudC-like protein Nudcd3 748.3 754.7 686.3 539.3 551.3 550.5 1.33404423862044 0.00117818318664854 0.415806508936355 Nonsignificant None -- -- -- -- -- Nuclear distribution protein NUDC T Signal transduction mechanisms ; IPR007052 [CS domain] ; IPR025934[NudC N-terminal domain] -- -- Q80Y14 Glutaredoxin-related protein 5, mitochondrial Glrx5 694.8 652 437.7 475 486.3 491.6 1.22823318879482 0.298891230640575 0.296584492613604 Nonsignificant None 3 Molecular Function:electron carrier activity (GO:0009055),Molecular Function:protein disulfide oxidoreductase activity (GO:0015035),Biological Process:cell redox homeostasis (GO:0045454) monothiol glutaredoxin -- -- Glutaredoxin-related protein O Posttranslational modification, protein turnover, chaperones ; IPR002109 [Glutaredoxin] -- -- Q9D6Y7 Mitochondrial peptide methionine sulfoxide reductase Msra 505.7 532.9 525.3 550.3 557.5 548.6 0.94415600096595 0.0226281774712954 -0.0829028420527099 Nonsignificant None 2 Molecular Function:peptide-methionine (S)-S-oxide reductase activity (GO:0008113),Biological Process:oxidation-reduction process (GO:0055114) peptide-methionine (S)-S-oxide reductase 1.8.4.11 -- Peptide methionine sulfoxide reductase O Posttranslational modification, protein turnover, chaperones ; IPR002569 [Peptide methionine sulphoxide reductase MsrA] -- -- A0A498WGL8 Protein-serine/threonine phosphatase Ssh3 556.4 537.6 591 605.1 658.2 673.7 0.869901910170366 0.031952141883928 -0.201075362534033 Nonsignificant None 2 Biological Process:protein dephosphorylation (GO:0006470),Molecular Function:protein tyrosine/serine/threonine phosphatase activity (GO:0008138) -- -- ko04360 Axon guidance ko04810 Regulation of actin cytoskeleton -- -- -- IPR000340 [Dual specificity phosphatase, catalytic domain] ; IPR014876[DEK, C-terminal] -- -- Q9QZ23 NFU1 iron-sulfur cluster scaffold homolog, mitochondrial Nfu1 946.5 896.1 1016 1094.2 973.4 1015.6 0.927153606642449 0.205762785128403 -0.109119717004383 Nonsignificant None 3 Molecular Function:iron ion binding (GO:0005506),Biological Process:iron-sulfur cluster assembly (GO:0016226),Molecular Function:iron-sulfur cluster binding (GO:0051536) NFU1 iron-sulfur cluster scaffold homolog, mitochondrial -- -- NifU-like domain-containing proteins O Posttranslational modification, protein turnover, chaperones ; IPR001075 [NIF system FeS cluster assembly, NifU, C-terminal] ; IPR014824[Scaffold protein Nfu/NifU, N-terminal] -- -- D3YVW2 Golgi integral membrane protein 4 Golim4 1712 1748.5 2229.6 2091.4 1969 1805.5 0.970030174397791 0.768725588554423 -0.0438984694670064 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- A2APM3 CD44 antigen Cd44 632.6 765.9 742.9 606.5 598 556.6 1.21594458009199 0.0447636261535797 0.282077475616625 Nonsignificant None 2 Molecular Function:hyaluronic acid binding (GO:0005540),Biological Process:cell adhesion (GO:0007155) CD44 antigen -- ko04512 ECM-receptor interaction ko04640 Hematopoietic cell lineage ko05169 Epstein-Barr virus infection ko05205 Proteoglycans in cancer ko05206 MicroRNAs in cancer -- -- -- IPR000538 [Link domain] -- -- Q3TAQ9 WD repeat domain 36 Wdr36 229.2 230.7 204.1 198.8 187.3 200.3 1.13233287858117 0.0536942112147059 0.179298138100475 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Biological Process:rRNA processing (GO:0006364),Cellular Component:small-subunit processome (GO:0032040) U3 small nucleolar RNA-associated protein 21 -- ko03008 Ribosome biogenesis in eukaryotes WD repeat protein R General function prediction only ; IPR001680 [WD40 repeat] ; IPR007319[Small-subunit processome, Utp21] ; IPR024977[Anaphase-promoting complex subunit 4, WD40 domain] -- -- F8VQ87 5-3 exoribonuclease 1 Xrn1 298.6 291 247.8 301.6 340.4 310 0.879621848739496 0.124888714655633 -0.185044655455004 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:exonuclease activity (GO:0004527) 5'-3' exoribonuclease 1 3.1.13.- ko03008 Ribosome biogenesis in eukaryotes ko03018 RNA degradation 5'-3' exonuclease XRN1/KEM1/SEP1 involved in DNA strand exchange and mRNA turnover LD Replication, recombination and repair ; Cell cycle control, cell division, chromosome partitioning ; IPR004859 [Putative 5-3 exonuclease] -- -- G5E8F8 Integrin beta Itgb5 291.6 302.7 272 317.1 332.1 335.8 0.879492385786802 0.0205058854387733 -0.185257007281283 Nonsignificant None -- -- integrin beta 5 -- ko04145 Phagosome ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04810 Regulation of actin cytoskeleton ko05165 Human papillomavirus infection ko05205 Proteoglycans in cancer ko05410 Hypertrophic cardiomyopathy (HCM) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05414 Dilated cardiomyopathy (DCM) Integrin beta subunit (N-terminal portion of extracellular region) TW Signal transduction mechanisms ; Extracellular structures ; IPR002369 [Integrin beta subunit, VWA domain] ; IPR012896[Integrin beta subunit, tail] ; IPR033760[Integrin beta N-terminal] -- -- Q8VD65 Phosphoinositide 3-kinase regulatory subunit 4 Pik3r4 244.1 278.9 305.8 268.9 301 285.3 0.969130028063611 0.68443181224411 -0.0452378500339368 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) phosphoinositide-3-kinase, regulatory subunit 4 2.7.11.1 ko04136 Autophagy - other ko04140 Autophagy - animal ko04371 Apelin signaling pathway Protein kinase containing WD40 repeats T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR001680[WD40 repeat] -- -- P49935 Pro-cathepsin H Ctsh 630.4 622 630.8 610 706.6 602.3 0.981395591224139 0.757176987547159 -0.0270933045626956 Nonsignificant None 2 Biological Process:proteolysis (GO:0006508),Molecular Function:cysteine-type peptidase activity (GO:0008234) cathepsin H 3.4.22.16 ko04142 Lysosome ko04210 Apoptosis Cysteine proteinase Cathepsin L O Posttranslational modification, protein turnover, chaperones ; IPR000668 [Peptidase C1A, papain C-terminal] ; IPR013201[Cathepsin propeptide inhibitor domain (I29)] -- -- Q8BY26 AAA domain-containing protein Rfc3 229.7 265.4 264.3 252 272.3 258.9 0.969611848825332 0.578822592732108 -0.044520765984606 Nonsignificant None -- -- replication factor C subunit 3/5 -- ko03030 DNA replication ko03420 Nucleotide excision repair ko03430 Mismatch repair Replication factor C, subunit RFC3 DL Cell cycle control, cell division, chromosome partitioning ; Replication, recombination and repair ; -- -- -- A2AKD7 Alpha-1-syntrophin Snta1 75 74.2 96.2 115.8 102.3 120.7 0.724321133412042 0.0264209203686556 -0.465298625669294 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Syntrophins (type beta) W Extracellular structures ; IPR001478 [PDZ domain] ; IPR001849[Pleckstrin homology domain] -- -- Q6KCD5 Nipped-B-like protein Nipbl 87.6 90.2 105.5 92.4 94 92.1 1.01723518850987 0.801961989230645 0.0246532741507047 Nonsignificant None -- -- cohesin loading factor subunit SCC2 -- Sister chromatid cohesion protein SCC2/Nipped-B BDL Chromatin structure and dynamics ; Cell cycle control, cell division, chromosome partitioning ; Replication, recombination and repair ; IPR024986 [Sister chromatid cohesion C-terminal domain] ; IPR026003[HEAT repeat associated with sister chromatid cohesion protein] -- -- A2RT28 Methionine--tRNA ligase, mitochondrial Mars2 211.8 199.2 181.3 188.1 186.2 191.6 1.04665135182895 0.383023252119968 0.0657809487122311 Nonsignificant None 4 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation for protein translation (GO:0006418) methionyl-tRNA synthetase 6.1.1.10 ko00450 Selenocompound metabolism ko00970 Aminoacyl-tRNA biosynthesis Methionyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR015413 [Methionyl/Leucyl tRNA synthetase] -- -- Q3UE37 Ubiquitin-conjugating enzyme E2 Z Ube2z 997.7 933.5 817.9 770.8 787.7 826 1.15290417278255 0.0919936502362137 0.205272603885826 Nonsignificant None -- -- ubiquitin-conjugating enzyme E2 Z 2.3.2.23 ko04120 Ubiquitin mediated proteolysis Ubiquitin-conjugating enzyme O Posttranslational modification, protein turnover, chaperones ; IPR000608 [Ubiquitin-conjugating enzyme E2] -- -- Q4PZA2 Endothelin-converting enzyme 1 Ece1 598.2 631.2 707.8 779.1 808.1 758.9 0.825710754017305 0.0184068825735051 -0.276291599955925 Nonsignificant None 2 Molecular Function:metalloendopeptidase activity (GO:0004222),Biological Process:proteolysis (GO:0006508) endothelin-converting enzyme 3.4.24.71 -- M13 family peptidase E Amino acid transport and metabolism ; IPR008753 [Peptidase M13, N-terminal domain] ; IPR018497[Peptidase M13, C-terminal domain] -- -- Q8R2M2 Deoxynucleotidyltransferase terminal-interacting protein 2 Dnttip2 365.4 407.4 381.4 397.5 428 396.5 0.944517184942717 0.231146761965102 -0.0823510490348711 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR014810 [Fcf2 pre-rRNA processing] -- -- Q9D902 General transcription factor IIE subunit 2 Gtf2e2 588.7 591.7 586.3 516.1 536.4 552.5 1.1007476635514 0.0337170014636472 0.138483782011455 Nonsignificant None 1 Biological Process:transcription initiation from RNA polymerase II promoter (GO:0006367) transcription initiation factor TFIIE subunit beta -- ko03022 Basal transcription factors ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis Transcription initiation factor IIE, beta subunit K Transcription ; IPR003166 [Transcription factor TFIIE beta subunit, DNA-binding domain] -- -- Q9WUR9 Adenylate kinase 4, mitochondrial Ak4 571.2 541.4 511 518.8 529.6 563.3 1.00738350809704 0.865351224168379 0.0106130179020962 Nonsignificant None 1 Molecular Function:adenylate kinase activity (GO:0004017) adenylate kinase 2.7.4.3 ko00230 Purine metabolism ko00730 Thiamine metabolism ko01100 Metabolic pathways Adenylate kinase F Nucleotide transport and metabolism ; IPR007862 [Adenylate kinase, active site lid domain] -- -- Q7M754 Try10-like trypsinogen Gm5409 100.8 81.6 76.7 73.1 94.6 79.6 1.04771532551557 0.70661898733809 0.0672467757901566 Nonsignificant None 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) -- -- -- Trypsin E Amino acid transport and metabolism ; IPR001254 [Serine proteases, trypsin domain] -- -- E9Q238 KN motif and ankyrin repeat domains 1 Kank1 211.6 212.3 163.5 184.8 197.1 199.8 1.00979886539453 0.915393898561362 0.0140679614969027 Nonsignificant None -- -- -- -- -- Ankyrin repeat protein R General function prediction only ; IPR020683 [Ankyrin repeat-containing domain] ; IPR021939[Kank N-terminal motif] -- -- O88952 Protein lin-7 homolog C Lin7c 1265.2 1204.7 1360 1285.3 1288.2 1342.3 0.97806323101282 0.589238819974167 -0.0320003576037053 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) protein lin-7 -- -- Receptor targeting protein Lin-7 W Extracellular structures ; IPR001478 [PDZ domain] ; IPR014775[L27 domain, C-terminal] -- -- Q6PKB0 Fcgrt protein Fcgrt 601.7 656.9 507.5 448.4 469.2 473.7 1.26938834183857 0.0478379256043427 0.344133497970515 Nonsignificant None -- -- -- -- -- -- -- -- IPR003597 [Immunoglobulin C1-set] ; IPR011161[MHC class I-like antigen recognition-like] -- -- E0CZ78 Serine/threonine-protein phosphatase Ppp3cb 55.3 61.7 66.5 53.3 59.4 57.4 1.0787771898883 0.294732547560065 0.10939692206719 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) serine/threonine-protein phosphatase 2B catalytic subunit 3.1.3.16 ko04010 MAPK signaling pathway ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04114 Oocyte meiosis ko04218 Cellular senescence ko04310 Wnt signaling pathway ko04360 Axon guidance ko04370 VEGF signaling pathway ko04380 Osteoclast differentiation ko04650 Natural killer cell mediated cytotoxicity ko04658 Th1 and Th2 cell differentiation ko04659 Th17 cell differentiation ko04660 T cell receptor signaling pathway ko04662 B cell receptor signaling pathway ko04720 Long-term potentiation ko04724 Glutamatergic synapse ko04728 Dopaminergic synapse ko04921 Oxytocin signaling pathway ko04922 Glucagon signaling pathway ko04924 Renin secretion ko05010 Alzheimer's disease ko05014 Amyotrophic lateral sclerosis (ALS) ko05031 Amphetamine addiction ko05152 Tuberculosis ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection Serine-threonine phosphatase 2B, catalytic subunit R General function prediction only ; IPR004843 [Calcineurin-like phosphoesterase domain, ApaH type] -- -- P56213 FAD-linked sulfhydryl oxidase ALR Gfer 774.4 710.6 592.4 794.4 715.4 752.4 0.918309610114048 0.348029381194024 -0.122947451412448 Nonsignificant None 2 Molecular Function:thiol oxidase activity (GO:0016972),Biological Process:oxidation-reduction process (GO:0055114) mitochondrial FAD-linked sulfhydryl oxidase 1.8.3.2 -- Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins O Posttranslational modification, protein turnover, chaperones ; IPR017905 [ERV/ALR sulfhydryl oxidase domain] -- -- Q3TCY0 Uncharacterized protein Rab33b 413.6 429.4 484.9 450.4 493.9 453.8 0.949788999356269 0.414715752649488 -0.0743210481731763 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-33B -- ko04140 Autophagy - animal GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- Q8CHP5 Partner of Y14 and mago Pym1 302.4 287.3 227.5 202.7 215.3 198.7 1.32511756121291 0.046165525300836 0.40612035775521 Nonsignificant None -- -- partner of Y14 and mago -- ko03013 RNA transport ko03015 mRNA surveillance pathway Uncharacterized conserved protein S Function unknown ; IPR015362 [WIBG family] -- -- E9Q499 Serine protease inhibitor A3G (Fragment) Serpina3g 58 66.9 53.6 48 48.6 52.1 1.20040349697377 0.0732679878420147 0.263519426864043 Nonsignificant None -- -- serpin peptidase inhibitor, clade A -- -- Serpin V Defense mechanisms ; IPR023796 [Serpin domain] -- -- P70444 BH3-interacting domain death agonist Bid 568.4 579.7 1294.6 514.5 503.6 488.9 1.62090245520902 0.323644064552986 0.696797273075961 Nonsignificant None 2 Cellular Component:cytoplasm (GO:0005737),Biological Process:positive regulation of apoptotic process (GO:0043065) BH3 interacting domain death agonist -- ko01524 Platinum drug resistance ko04071 Sphingolipid signaling pathway ko04115 p53 signaling pathway ko04210 Apoptosis ko04215 Apoptosis - multiple species ko04217 Necroptosis ko04650 Natural killer cell mediated cytotoxicity ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05014 Amyotrophic lateral sclerosis (ALS) ko05152 Tuberculosis ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05200 Pathways in cancer ko05416 Viral myocarditis -- -- -- IPR010479 [BH3-interacting domain death agonist] -- -- Q8K268 ATP-binding cassette sub-family F member 3 Abcf3 232.3 215.4 159.1 158.7 154.6 182 1.22511609125782 0.192144466580374 0.292918464612619 Nonsignificant None 2 Molecular Function:ATP binding (GO:0005524),Molecular Function:ATPase activity (GO:0016887) ATP-binding cassette, subfamily F, member 3 -- -- ATPase component of ABC transporters with duplicated ATPase domains/Translation elongation factor EF-3b EJ Amino acid transport and metabolism ; Translation, ribosomal structure and biogenesis ; IPR003439 [ABC transporter-like] ; IPR032781[ABC-transporter extension domain] -- -- Q640N1 Adipocyte enhancer-binding protein 1 Aebp1 895.9 869.5 995.7 934 899.8 907.2 1.0073330901131 0.874512677220491 0.0105408114433954 Nonsignificant None 3 Molecular Function:metallocarboxypeptidase activity (GO:0004181),Biological Process:proteolysis (GO:0006508),Molecular Function:zinc ion binding (GO:0008270) adipocyte enhancer-binding protein 1 -- -- Zinc carboxypeptidase R General function prediction only ; IPR000421 [Coagulation factor 5/8 C-terminal domain] ; IPR000834[Peptidase M14, carboxypeptidase A] -- -- A2AH75 Kinesin-like protein KIF1B Kif1b 42.2 50.9 67.6 54.7 47.8 53.4 1.03078896728672 0.846470408257843 0.0437490009773088 Nonsignificant None 5 Molecular Function:microtubule motor activity (GO:0003777),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Biological Process:microtubule-based movement (GO:0007018),Molecular Function:microtubule binding (GO:0008017) kinesin family member 1 -- -- Kinesin-like protein Z Cytoskeleton ; IPR000253 [Forkhead-associated (FHA) domain] ; IPR001752[Kinesin motor domain] ; IPR032405[Kinesin-associated] -- -- P59708 Splicing factor 3B subunit 6 Sf3b6 766.8 738.7 850.6 790.1 811.6 802.8 0.979871075067582 0.661558582704749 -0.0293361534109358 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) pre-mRNA branch site protein p14 -- ko03040 Spliceosome Predicted RNA-binding protein (RRM superfamily) R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- Q91VU7 Pseudouridylate synthase 7 homolog Pus7 806 904.2 1057.5 984.9 997.1 990 0.931258411843876 0.450367148051098 -0.102746542832572 Nonsignificant None 4 Biological Process:pseudouridine synthesis (GO:0001522),Molecular Function:RNA binding (GO:0003723),Biological Process:RNA modification (GO:0009451),Molecular Function:pseudouridine synthase activity (GO:0009982) tRNA pseudouridine13 synthase 5.4.99.27 -- Uncharacterized conserved protein S Function unknown ; IPR001656 [Pseudouridine synthase, TruD] -- -- Q9DB34 Charged multivesicular body protein 2a Chmp2a 1098.3 1062.4 1102.6 1045.9 1107.9 1045.3 1.02006814416555 0.42938320172215 0.0286655325554535 Nonsignificant None 1 Biological Process:vacuolar transport (GO:0007034) charged multivesicular body protein 2A -- ko04144 Endocytosis ko04217 Necroptosis Vacuolar assembly/sorting protein DID4 U Intracellular trafficking, secretion, and vesicular transport ; IPR005024 [Snf7 family] -- -- Q7TPZ8 Carboxypeptidase A1 Cpa1 268.3 236.7 196.7 247.1 637.2 264 0.611077244622485 0.312704126660475 -0.710573336136228 Nonsignificant None 4 Molecular Function:carboxypeptidase activity (GO:0004180),Molecular Function:metallocarboxypeptidase activity (GO:0004181),Biological Process:proteolysis (GO:0006508),Molecular Function:zinc ion binding (GO:0008270) carboxypeptidase A1 3.4.17.1 ko04972 Pancreatic secretion ko04974 Protein digestion and absorption Zinc carboxypeptidase S Function unknown ; IPR000834 [Peptidase M14, carboxypeptidase A] ; IPR003146[Carboxypeptidase, activation peptide] -- -- Q3TSA8 Secretory carrier-associated membrane protein Scamp1 960.2 935.8 853.7 980.6 984.4 1018.2 0.921728345400912 0.0861688372726101 -0.117586477085702 Nonsignificant None 2 Biological Process:protein transport (GO:0015031),Cellular Component:integral component of membrane (GO:0016021) secretory carrier-associated membrane protein -- -- Secretory carrier membrane protein U Intracellular trafficking, secretion, and vesicular transport ; IPR007273 [SCAMP] -- -- Q5FW62 Serine (Or cysteine) peptidase inhibitor, clade D, member 1 Serpind1 976.4 1001.1 712.7 443.1 475.8 468.6 1.93888288288288 0.0409415612566469 0.955225660903673 Significant up -- -- heparin cofactor II -- ko04610 Complement and coagulation cascades Serpin V Defense mechanisms ; IPR023796 [Serpin domain] -- -- Q69ZR2 E3 ubiquitin-protein ligase HECTD1 Hectd1 1491.7 1503.4 1413.6 1289.3 1276.8 1244.1 1.15707836858958 0.00308651339708 0.210486581080345 Nonsignificant None 3 Molecular Function:ubiquitin-protein transferase activity (GO:0004842),Biological Process:protein ubiquitination (GO:0016567),Molecular Function:metal ion binding (GO:0046872) E3 ubiquitin-protein ligase HECTD1 2.3.2.26 -- Predicted hormone receptor interactor R General function prediction only ; IPR000569 [HECT domain] ; IPR010606[Mib-herc2] ; IPR012919[SUN domain] ; IPR020683[Ankyrin repeat-containing domain] -- -- Q5EBG8 Uncharacterized protein C1orf50 homolog 198.9 183.1 184.4 219.4 210.7 212.4 0.881556420233463 0.011387828017711 -0.181875188885605 Nonsignificant None -- -- -- -- -- -- -- -- IPR019534 [Protein of unknown function DUF2452] -- -- Q8R035 Peptidyl-tRNA hydrolase ICT1, mitochondrial Mrpl58 1031.7 1008 1172.6 1098.2 1070.9 1121.6 0.976175281854924 0.650323354734618 -0.0347878737814641 Nonsignificant None 2 Molecular Function:translation release factor activity (GO:0003747),Biological Process:translational termination (GO:0006415) peptidyl-tRNA hydrolase ICT1 3.1.1.29 -- Predicted peptidyl-tRNA hydrolase J Translation, ribosomal structure and biogenesis ; IPR000352 [Peptide chain release factor class I/class II] -- -- Q6ZQ74 MKIAA0666 protein (Fragment) Daam1 603.7 644.3 670.7 703 675.7 663.1 0.9397100597512 0.145850169364759 -0.0897124018027854 Nonsignificant None 4 Molecular Function:actin binding (GO:0003779),Biological Process:cellular component organization (GO:0016043),Molecular Function:Rho GTPase binding (GO:0017048),Biological Process:actin cytoskeleton organization (GO:0030036) dishevelled associated activator of morphogenesis -- ko04310 Wnt signaling pathway Rho GTPase effector BNI1 and related formins TZ Signal transduction mechanisms ; Cytoskeleton ; IPR010472 [Formin, FH3 domain] ; IPR010473[Formin, GTPase-binding domain] ; IPR015425[Formin, FH2 domain] -- -- Q8C1Y8 Vacuolar fusion protein CCZ1 homolog Ccz1 670.4 675.9 656.4 689.8 680.6 690.5 0.971759910718618 0.0428553882634506 -0.0413281785881946 Nonsignificant None -- -- -- -- -- Putative myrosinase precursor V Defense mechanisms ; IPR013176 [Protein of unknown function DUF1712, fungi] -- -- O35075 Vacuolar protein sorting-associated protein 26C Vps26c 296.8 291.8 338.8 313.4 331 306.3 0.975491742926265 0.664483675124613 -0.0357984337288641 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein with similarity to embryogenesis protein H beta 58 and VPS26 R General function prediction only ; IPR028934 [Vacuolar protein sorting protein 26 related] -- -- P08551 Neurofilament light polypeptide Nefl 359.2 369.5 428.1 466.7 462.2 457.6 0.834331049404977 0.0682784572459393 -0.261308158975723 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) neurofilament light polypeptide -- ko05014 Amyotrophic lateral sclerosis (ALS) -- -- -- IPR001664 [Intermediate filament protein] ; IPR006821[Intermediate filament head, DNA-binding domain] -- -- Q9Z1Q2 Phosphatidylserine lipase ABHD16A Abhd16a 981.7 909.4 1021.8 1040.6 999.9 1036.4 0.946699600247002 0.196757919453169 -0.0790213819560781 Nonsignificant None -- -- -- -- -- Predicted alpha/beta hydrolase BAT5 R General function prediction only ; IPR000073 [Alpha/beta hydrolase fold-1] -- -- Q80U56 Late secretory pathway protein AVL9 homolog Avl9 184.2 209.8 179.7 236.5 222.3 211 0.856524335622574 0.0549169536567029 -0.223433858054747 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR018307 [AVL9/DENND6 domain] -- -- Q5NCJ9 Complex III subunit 9 Uqcr10 529 544.6 590.2 715.8 696.1 696.7 0.789054348857062 0.00159531979549516 -0.34180342059773 Nonsignificant None 2 Cellular Component:mitochondrial inner membrane (GO:0005743),Cellular Component:mitochondrial respiratory chain complex III (GO:0005750) ubiquinol-cytochrome c reductase subunit 9 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04260 Cardiac muscle contraction ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Ubiquinol cytochrome c oxidoreductase, subunit QCR9 C Energy production and conversion ; IPR008027 [Cytochrome b-c1 complex subunit 9] -- -- Q3TJX6 Uncharacterized protein Utp18 527.3 550.8 504.7 365.9 371.1 372.2 1.42697439596105 0.00615549574477274 0.512959448933222 Nonsignificant None -- -- U3 small nucleolar RNA-associated protein 18 -- ko03008 Ribosome biogenesis in eukaryotes WD40 repeat protein R General function prediction only ; -- -- -- Q8CD92 Tetratricopeptide repeat protein 27 Ttc27 589.6 613.7 518.5 478.1 481.2 527.7 1.15790181573638 0.0753084460342212 0.211512925213464 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Uncharacterized conserved protein, contains TPR repeats R General function prediction only ; IPR019734 [Tetratricopeptide repeat] -- -- Q14DI6 Acyl-CoA thioesterase 4 Acot4 14.2 9.9 21.4 12.4 8.5 11 1.42633228840125 0.269935327332671 0.512310121321189 Nonsignificant None -- -- acyl-coenzyme A thioesterase 1/2/4 3.1.2.2 ko00062 Fatty acid elongation ko01040 Biosynthesis of unsaturated fatty acids ko01100 Metabolic pathways -- -- -- IPR006862 [Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase] ; IPR014940[BAAT/Acyl-CoA thioester hydrolase C-terminal] -- -- Q9QUJ7 Long-chain-fatty-acid--CoA ligase 4 Acsl4 326.3 415.9 400.3 457.1 591.9 356.5 0.812877979366773 0.299338946138504 -0.298889288434911 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) long-chain acyl-CoA synthetase 6.2.1.3 ko00061 Fatty acid biosynthesis ko00071 Fatty acid degradation ko01100 Metabolic pathways ko01212 Fatty acid metabolism ko03320 PPAR signaling pathway ko04146 Peroxisome ko04216 Ferroptosis ko04920 Adipocytokine signaling pathway Acyl-CoA synthetase I Lipid transport and metabolism ; IPR000873 [AMP-dependent synthetase/ligase] -- -- Q91VE6 MKI67 FHA domain-interacting nucleolar phosphoprotein Nifk 524.2 530.9 337.1 359.4 361.9 341.4 1.3100592829585 0.224958879626398 0.389632098247509 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) nucleolar protein 15 -- -- Nucleolar RNA-binding protein NIFK R General function prediction only ; IPR000504 [RNA recognition motif domain] ; IPR021043[MKI67 FHA domain-interacting nucleolar phosphoprotein, FHA Ki67 binding] -- -- A0A338P7E3 Ribonuclease T2-B Rnaset2b 1386 1464.3 1691.4 1553.1 1398.8 1616.3 0.99419902806357 0.940962734472312 -0.00839340199564953 Nonsignificant None 2 Molecular Function:RNA binding (GO:0003723),Molecular Function:ribonuclease T2 activity (GO:0033897) ribonuclease T2 3.1.27.1 -- Ribonuclease, T2 family A RNA processing and modification ; IPR001568 [Ribonuclease T2-like] -- -- P60521 Gamma-aminobutyric acid receptor-associated protein-like 2 Gabarapl2 738.5 720 730.3 643.3 706.2 714.5 1.06046511627907 0.146176217214528 0.0846971645752813 Nonsignificant None -- -- GABA(A) receptor-associated protein -- ko04068 FoxO signaling pathway ko04136 Autophagy - other ko04137 Mitophagy - animal ko04140 Autophagy - animal ko04371 Apelin signaling pathway ko04621 NOD-like receptor signaling pathway ko04727 GABAergic synapse ko05167 Kaposi's sarcoma-associated herpesvirus infection Microtubule-associated anchor protein involved in autophagy and membrane trafficking Z Cytoskeleton ; IPR004241 [Autophagy protein Atg8 ubiquitin-like] -- -- P43024 Cytochrome c oxidase subunit 6A1, mitochondrial Cox6a1 468.6 644.5 712.2 998.7 955.5 910.7 0.63712520506824 0.0107771287713509 -0.650351182403742 Significant down 3 Molecular Function:cytochrome-c oxidase activity (GO:0004129),Cellular Component:mitochondrial inner membrane (GO:0005743),Cellular Component:mitochondrial respiratory chain complex IV (GO:0005751) cytochrome c oxidase subunit 6a -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04260 Cardiac muscle contraction ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Cytochrome c oxidase, subunit VIa/COX13 C Energy production and conversion ; IPR001349 [Cytochrome c oxidase, subunit VIa] -- -- Q8VBV3 Exosome complex component RRP4 Exosc2 277.4 270.9 264.6 313 309.7 322.6 0.859938643816778 0.00117804832626755 -0.217694366955248 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) exosome complex component RRP4 -- ko03018 RNA degradation Exosomal 3'-5' exoribonuclease complex, subunit Rrp4 A RNA processing and modification ; IPR004088 [K Homology domain, type 1] ; IPR025721[Exosome complex component, N-terminal domain] -- -- Q8CD15 Ribosomal oxygenase 2 Riox2 755.1 694.9 577.5 553.8 588.6 578.3 1.17829952926135 0.126718045357251 0.236706325629015 Nonsignificant None -- -- bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA 1.14.11.- -- Uncharacterized conserved protein S Function unknown ; IPR003347 [JmjC domain] -- -- E9QMU3 Ensconsin Map7 536.7 523.1 456.4 567.8 559.9 542.4 0.907849829351536 0.11894305247684 -0.139474418921058 Nonsignificant None 2 Biological Process:microtubule cytoskeleton organization (GO:0000226),Cellular Component:microtubule cytoskeleton (GO:0015630) microtubule-associated protein 7 -- -- -- -- -- IPR008604 [Microtubule-associated protein 7 family] -- -- Q9CTE8 Dolichyl-phosphate beta-glucosyltransferase (Fragment) Alg5 858 881.4 869.9 778.3 769.3 757.6 1.13191913933715 0.000358694366260346 0.178770900357069 Nonsignificant None -- -- dolichyl-phosphate beta-glucosyltransferase 2.4.1.117 ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways Glycosyltransferase R General function prediction only ; IPR001173 [Glycosyltransferase 2-like] -- -- E9Q8X9 Actin filament-associated protein 1 (Fragment) Afap1 151.6 139.4 131.9 158.1 169.3 135.9 0.912799481977121 0.301824485343431 -0.13163012200447 Nonsignificant None -- -- actin filament associated protein 1 -- -- -- -- -- IPR001849 [Pleckstrin homology domain] -- -- A2APF7 Z-DNA-binding protein 1 Zbp1 281.9 272.2 278.9 264.8 322.9 293.9 0.944872958257713 0.394969531845476 -0.0818077283182479 Nonsignificant None 2 Molecular Function:RNA binding (GO:0003723),Molecular Function:double-stranded RNA adenosine deaminase activity (GO:0003726) Z-DNA binding protein 1 -- ko04217 Necroptosis ko04623 Cytosolic DNA-sensing pathway -- -- -- IPR000607 [Double-stranded RNA-specific adenosine deaminase (DRADA)] ; IPR025735[RHIM domain] -- -- Q922V4 Pleiotropic regulator 1 Plrg1 270.3 265.5 245.1 233.9 239 262.5 1.06187109056296 0.26513315425418 0.0866086359219721 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) pleiotropic regulator 1 -- ko03040 Spliceosome Pleiotropic regulator 1 A RNA processing and modification ; IPR001680 [WD40 repeat] -- -- Q7TPS7 Nfyc protein Nfyc 1116.5 1172.6 1071.5 1030.9 1095 1061.1 1.05447128961406 0.169865743279896 0.0765198150032989 Nonsignificant None -- -- nuclear transcription factor Y, gamma -- ko04612 Antigen processing and presentation ko05152 Tuberculosis CCAAT-binding factor, subunit C (HAP5) K Transcription ; IPR003958 [Transcription factor CBF/NF-Y/archaeal histone domain] -- NF-YC Q4JFI8 Pentaxin Apcs 1123.2 1148.6 1083.1 670.8 666.1 778.9 1.58564136496833 0.000571521080076214 0.665066504024697 Significant up -- -- -- -- -- -- -- -- IPR001759 [Pentraxin-related] -- -- A6PW47 Mediator of RNA polymerase II transcription subunit 24 Med24 255.9 235 245.6 201.1 199.8 235.6 1.15710919088767 0.0647838435851164 0.210525011134491 Nonsignificant None -- -- mediator of RNA polymerase II transcription subunit 24 -- ko04919 Thyroid hormone signaling pathway -- -- -- IPR021429 [Mediator complex, subunit Med24, N-terminal] -- -- Q5NC03 LIM domain kinase 2 Limk2 990 935.7 870.4 826.9 889.8 917.4 1.06150108196348 0.284485826864851 0.0861058417496966 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein binding (GO:0005515),Biological Process:protein phosphorylation (GO:0006468),Molecular Function:zinc ion binding (GO:0008270) LIM domain kinase 2 2.7.11.1 ko04360 Axon guidance ko04666 Fc gamma R-mediated phagocytosis ko04810 Regulation of actin cytoskeleton -- -- -- IPR001245 [Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR001478[PDZ domain] ; IPR001781[Zinc finger, LIM-type] -- -- A0A0R4J1I5 Forkhead box protein P4 Foxp4 219.4 211 211.3 213.7 199.5 224.1 1.00690412678487 0.857153758342879 0.00992632247405673 Nonsignificant None 1 Molecular Function:sequence-specific DNA binding (GO:0043565) forkhead box protein P -- -- Predicted forkhead transcription factor K Transcription ; IPR001766 [Fork head domain] ; IPR032354[FOXP, coiled-coil domain] -- Fork head Q9R097 Kunitz-type protease inhibitor 1 Spint1 1135.2 1103.6 1336.4 1299.1 1342.3 1276.4 0.912552963397825 0.204566119356319 -0.132019801416684 Nonsignificant None 2 Molecular Function:serine-type endopeptidase inhibitor activity (GO:0004867),Molecular Function:protein binding (GO:0005515) Kunitz-type protease inhibitor 1 -- ko05202 Transcriptional misregulation in cancer ko05215 Prostate cancer Serine proteinase inhibitor (KU family) O Posttranslational modification, protein turnover, chaperones ; IPR002172 [Low-density lipoprotein (LDL) receptor class A repeat] ; IPR002223[Pancreatic trypsin inhibitor Kunitz domain] ; IPR011106[Seven cysteines, N-terminal] -- -- Q91W96 Anaphase-promoting complex subunit 4 Anapc4 140.9 136 116.2 129.6 129.9 119.7 1.03665611814346 0.604800909722734 0.0519373995258349 Nonsignificant None -- -- anaphase-promoting complex subunit 4 -- ko04110 Cell cycle ko04114 Oocyte meiosis ko04120 Ubiquitin mediated proteolysis ko04914 Progesterone-mediated oocyte maturation ko05166 HTLV-I infection Anaphase-promoting complex (APC), subunit 4 DO Cell cycle control, cell division, chromosome partitioning ; Posttranslational modification, protein turnover, chaperones ; IPR024790 [Anaphase-promoting complex subunit 4 long domain] ; IPR024977[Anaphase-promoting complex subunit 4, WD40 domain] -- -- Q3UK06 Uncharacterized protein Cyp4f16 311.3 295.8 319.3 345 343.7 317.7 0.920508744038156 0.0768489121991266 -0.119496668890053 Nonsignificant None 3 Molecular Function:iron ion binding (GO:0005506),Molecular Function:heme binding (GO:0020037),Biological Process:oxidation-reduction process (GO:0055114) cytochrome P450 family 4 subfamily F 1.14.14.1 -- Cytochrome P450 CYP4/CYP19/CYP26 subfamilies QI Secondary metabolites biosynthesis, transport and catabolism ; Lipid transport and metabolism ; IPR001128 [Cytochrome P450] -- -- Q91WX5 Bak1 protein Bak1 278.4 251.5 243.4 294.9 263.9 276.1 0.926218708827404 0.213660950765946 -0.110575196342931 Nonsignificant None -- -- Bcl-2 homologous antagonist/killer -- ko01524 Platinum drug resistance ko04141 Protein processing in endoplasmic reticulum ko04210 Apoptosis ko04215 Apoptosis - multiple species ko05165 Human papillomavirus infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05200 Pathways in cancer ko05202 Transcriptional misregulation in cancer ko05203 Viral carcinogenesis ko05206 MicroRNAs in cancer ko05210 Colorectal cancer ko05212 Pancreatic cancer ko05213 Endometrial cancer ko05214 Glioma ko05216 Thyroid cancer ko05217 Basal cell carcinoma ko05218 Melanoma ko05220 Chronic myeloid leukemia ko05222 Small cell lung cancer ko05223 Non-small cell lung cancer ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer Anti-apoptotic Bcl-2 family proteins, prevent opening of mitochondrial porin channel T Signal transduction mechanisms ; -- -- -- O08746 Matrilin-2 Matn2 644.2 603.4 652 697.1 736 677.1 0.900199033266989 0.0376377382665742 -0.151684079488126 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) -- -- -- Fibrillins and related proteins containing Ca2+-binding EGF-like domains T Signal transduction mechanisms ; IPR001881 [EGF-like calcium-binding domain] ; IPR002035[von Willebrand factor, type A] ; IPR019466[Matrilin, coiled-coil trimerisation domain] -- -- Q9CQ91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 Ndufa3 626.7 500.2 604.2 801.5 754.4 829.4 0.72573680459481 0.00816203144572586 -0.462481658994702 Nonsignificant None 2 Cellular Component:mitochondrial inner membrane (GO:0005743),Cellular Component:mitochondrial respiratory chain complex I (GO:0005747) NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 3 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease -- -- -- IPR026626 [NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3] -- -- Q3TMW7 Uncharacterized protein Glmn 342.1 346.3 361 368.2 353.3 366.1 0.96487679293858 0.159679816613987 -0.0515833613819513 Nonsignificant None -- -- -- -- -- -- -- -- IPR013877 [YAP-binding/ALF4/Glomulin] -- -- Q3UY41 TLE_N domain-containing protein Tle4 237.7 229.4 299.5 243 248.8 278.7 0.994938351719663 0.960589672308763 -0.00732095860162966 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Transducin-like enhancer of split protein (contains WD40 repeats) B Chromatin structure and dynamics ; IPR001680 [WD40 repeat] ; IPR005617[Groucho/TLE, N-terminal Q-rich domain] -- -- Q80XT4 Dihydropyrimidine dehydrogenase [NADP(+)] (Fragment) Dpyd 102.6 89.9 122 144.3 125.1 148.3 0.752932726837443 0.0430606681760408 -0.409407126396141 Nonsignificant None 3 Cellular Component:cytoplasm (GO:0005737),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) dihydropyrimidine dehydrogenase (NADP+) 1.3.1.2 ko00240 Pyrimidine metabolism ko00410 beta-Alanine metabolism ko00770 Pantothenate and CoA biosynthesis ko00983 Drug metabolism - other enzymes ko01100 Metabolic pathways Dihydropyrimidine dehydrogenase F Nucleotide transport and metabolism ; IPR005720 [Dihydroorotate dehydrogenase domain] ; IPR023753[FAD/NAD(P)-binding domain] -- -- Q2M4I1 E3 ubiquitin-protein ligase Ubr1 307.4 305.8 282.7 283.3 278.8 278.2 1.06616684517434 0.0851029204107226 0.0924332240918914 Nonsignificant None 2 Molecular Function:zinc ion binding (GO:0008270),Biological Process:protein catabolic process (GO:0030163) E3 ubiquitin-protein ligase UBR1 2.3.2.27 -- N-end rule pathway, recognition component UBR1 O Posttranslational modification, protein turnover, chaperones ; IPR003126 [Zinc finger, UBR-type] ; IPR003769[Adaptor protein ClpS, core] -- -- Q9DB73 NADH-cytochrome b5 reductase 1 Cyb5r1 441 430.7 473.7 492.7 497.9 510.6 0.896216360245137 0.0207112412165441 -0.158081032055622 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) cytochrome-b5 reductase 1.6.2.2 ko00520 Amino sugar and nucleotide sugar metabolism NADH-cytochrome b-5 reductase HC Coenzyme transport and metabolism ; Energy production and conversion ; IPR001433 [Oxidoreductase FAD/NAD(P)-binding] ; IPR008333[Oxidoreductase, FAD-binding domain] -- -- Q3V377 Leucine--tRNA ligase (Fragment) Lars2 377.9 351.2 374.5 400.1 430.4 417.3 0.884436608430838 0.0166870374004804 -0.177169352740279 Nonsignificant None 4 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation for protein translation (GO:0006418) leucyl-tRNA synthetase 6.1.1.4 ko00970 Aminoacyl-tRNA biosynthesis Leucyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR002300 [Aminoacyl-tRNA synthetase, class Ia] -- -- Q14B51 Polypeptide N-acetylgalactosaminyltransferase Galnt5 195.9 178.4 211.3 268.7 241.2 244.1 0.776657824933687 0.0121453346639964 -0.364648969871984 Nonsignificant None -- -- polypeptide N-acetylgalactosaminyltransferase 2.4.1.41 ko00512 Mucin type O-glycan biosynthesis ko01100 Metabolic pathways Polypeptide N-acetylgalactosaminyltransferase O Posttranslational modification, protein turnover, chaperones ; IPR000772 [Ricin B, lectin domain] ; IPR001173[Glycosyltransferase 2-like] -- -- Q3TCN2 Putative phospholipase B-like 2 Plbd2 598.2 660.7 882.8 887.6 848.6 806.2 0.842393014474512 0.209874780520407 -0.247434621990927 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein Lama T Signal transduction mechanisms ; IPR007000 [Phospholipase B-like] -- -- A2BDX2 Dolichol-phosphate mannosyltransferase subunit 1 Dpm1 1106.4 1128.4 1244.6 1213.2 1231.7 1185.2 0.958485992121429 0.326382767080468 -0.0611707472345422 Nonsignificant None -- -- dolichol-phosphate mannosyltransferase 2.4.1.83 ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways Dolichol-phosphate mannosyltransferase R General function prediction only ; IPR001173 [Glycosyltransferase 2-like] -- -- Q8K2T8 RNA polymerase II-associated factor 1 homolog Paf1 451.5 439.2 463.2 430.1 456.7 427.7 1.02997337390643 0.320513884395443 0.0426070424282353 Nonsignificant None 3 Biological Process:transcription elongation from RNA polymerase II promoter (GO:0006368),Biological Process:histone modification (GO:0016570),Cellular Component:Cdc73/Paf1 complex (GO:0016593) RNA polymerase II-associated factor 1 -- Putative RNA polymerase II regulator K Transcription ; IPR007133 [RNA polymerase II associated factor Paf1] -- -- Q8C541 Fatty acid amide hydrolase Faah 251.4 265.2 295.6 311.2 297.7 307.1 0.886681222707424 0.0643834629604926 -0.173512571059981 Nonsignificant None -- -- fatty acid amide hydrolase 3.5.1.99 ko04723 Retrograde endocannabinoid signaling Amidases JIT Translation, ribosomal structure and biogenesis ; Lipid transport and metabolism ; Signal transduction mechanisms ; IPR023631 [Amidase signature domain] -- -- E9QMN5 Transcriptional repressor p66 alpha Gatad2a 955.1 942.7 962.2 864.4 913.2 765 1.12483284826555 0.133768092220701 0.16971063086897 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR032346 [Transcriptional repressor p66, coiled-coil MBD2-interaction domain] -- -- Q7TPU5 TBC1 domain family, member 15 Tbc1d15 869.5 880.3 921.2 850.7 893.9 874.8 1.01969916774834 0.440442134252232 0.0281435902240841 Nonsignificant None -- -- TBC1 domain family member 15 -- ko04137 Mitophagy - animal Ypt/Rab-specific GTPase-activating protein GYP7 and related proteins T Signal transduction mechanisms ; IPR000195 [Rab-GTPase-TBC domain] ; IPR021935[Domain of unknown function DUF3548] -- -- A2A5V2 SH3 domain-binding protein 1 Sh3bp1 331.8 397.7 381.9 385.9 412.7 323.8 0.990199572344975 0.916834541224087 -0.0142087686694104 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Cellular Component:cytoplasm (GO:0005737),Biological Process:signal transduction (GO:0007165) SH3-domain binding protein 1 -- -- GTPase-activator protein T Signal transduction mechanisms ; IPR000198 [Rho GTPase-activating protein domain] ; IPR004148[BAR domain] -- -- E9Q6C1 Oxysterol-binding protein Osbpl9 1056 1036.9 1038.6 891.7 951.5 975.4 1.11101255942667 0.0152282317191396 0.151875125746043 Nonsignificant None -- -- oxysterol-binding protein-related protein 9/10/11 -- -- Oxysterol-binding protein T Signal transduction mechanisms ; IPR000648 [Oxysterol-binding protein] -- -- Q91ZE0 Trimethyllysine dioxygenase, mitochondrial Tmlhe 873.4 846.4 963.8 1034.7 972.6 1030 0.883547887926777 0.0443465739697013 -0.178619764522259 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) trimethyllysine dioxygenase 1.14.11.8 ko00310 Lysine degradation Predicted gamma-butyrobetaine,2-oxoglutarate dioxygenase I Lipid transport and metabolism ; IPR003819 [TauD/TfdA-like domain] ; IPR010376[Domain of unknown function DUF971] -- -- F6UK66 Coiled-coil domain-containing protein 50 (Fragment) Ccdc50 563.7 598.7 549 441.9 427.1 431.2 1.31625903707122 0.000877759503633329 0.396443436430917 Nonsignificant None -- -- -- -- -- -- -- -- IPR029311 [Coiled-coil domain-containing protein 50, N-terminal] -- -- Q8R3R8 Gamma-aminobutyric acid receptor-associated protein-like 1 Gabarapl1 252.5 245.7 197 222.3 224.5 236.9 1.01682024279655 0.842271866701117 0.0240646568279467 Nonsignificant None -- -- GABA(A) receptor-associated protein -- ko04068 FoxO signaling pathway ko04136 Autophagy - other ko04137 Mitophagy - animal ko04140 Autophagy - animal ko04371 Apelin signaling pathway ko04621 NOD-like receptor signaling pathway ko04727 GABAergic synapse ko05167 Kaposi's sarcoma-associated herpesvirus infection Microtubule-associated anchor protein involved in autophagy and membrane trafficking Z Cytoskeleton ; IPR004241 [Autophagy protein Atg8 ubiquitin-like] -- -- P01671 Ig kappa chain V-III region PC 7175 349.1 370.1 308.3 240.8 243.6 265.4 1.37036543078154 0.00938057369323645 0.454560663168317 Nonsignificant None -- -- pre-B lymphocyte gene -- -- -- -- -- IPR013106 [Immunoglobulin V-set domain] -- -- E9PV44 ATP synthase F1 subunit epsilon Atpif1 2451.7 2506.6 2226.1 2264.4 2231.8 2412.2 1.03995136355741 0.418951750205095 0.0565160579862655 Nonsignificant None 3 Cellular Component:mitochondrion (GO:0005739),Biological Process:negative regulation of ATPase activity (GO:0032780),Molecular Function:ATPase inhibitor activity (GO:0042030) ATPase inhibitor, mitochondrial -- -- -- -- -- IPR007648 [Mitochondrial ATPase inhibitor] -- -- O70145 Neutrophil cytosol factor 2 Ncf2 694.8 858 707.2 521.4 570.2 559.5 1.36878444673248 0.020407649232414 0.452895271931927 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) neutrophil cytosolic factor 2 -- ko04145 Phagosome ko04380 Osteoclast differentiation ko04670 Leukocyte transendothelial migration ko05140 Leishmaniasis ko05418 Fluid shear stress and atherosclerosis Sorbin and SH3 domain-containing protein T Signal transduction mechanisms ; IPR000270 [PB1 domain] ; IPR001440[Tetratricopeptide repeat 1] ; IPR001452[SH3 domain] ; IPR019734[Tetratricopeptide repeat] -- -- D3YTP8 U6 snRNA-associated Sm-like protein LSm4 (Fragment) Lsm4 1907.7 1611.2 1455.1 1307.1 1298.1 1528.9 1.20316392927118 0.140650144215799 0.266833220930017 Nonsignificant None -- -- U6 snRNA-associated Sm-like protein LSm4 -- ko03018 RNA degradation ko03040 Spliceosome Small nuclear ribonucleoprotein (snRNP) A RNA processing and modification ; IPR001163 [LSM domain, eukaryotic/archaea-type] -- -- Q4FJR0 Nudt4 protein Nudt4 940.9 1062.8 1221 1170.3 1177.1 1128.1 0.927837721191196 0.36831708383922 -0.108055594820292 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) diphosphoinositol-polyphosphate diphosphatase 3.6.1.52 -- Diadenosine and diphosphoinositol polyphosphate phosphohydrolase T Signal transduction mechanisms ; IPR000086 [NUDIX hydrolase domain] -- -- Q9WVG6 Histone-arginine methyltransferase CARM1 Carm1 808.3 880.4 943 882.1 873.1 886.3 0.996289986749953 0.940910584462866 -0.00536237111358189 Nonsignificant None 2 Biological Process:protein methylation (GO:0006479),Molecular Function:methyltransferase activity (GO:0008168) type I protein arginine methyltransferase 2.1.1.319 ko01522 Endocrine resistance Protein arginine N-methyltransferase CARM1 OK Posttranslational modification, protein turnover, chaperones ; Transcription ; IPR020989 [Histone-arginine methyltransferase CARM1, N-terminal] ; IPR025799[Protein arginine N-methyltransferase] -- -- D0QMC3 Myeloid cell nuclear differentiation antigen-like protein Mndal 120.9 123.7 117.3 132.1 138.9 128.3 0.90633608815427 0.0260131929389991 -0.141881964260509 Nonsignificant None -- -- -- -- -- -- -- -- IPR004020 [DAPIN domain] ; IPR004021[HIN-200/IF120x] -- -- Q99NB8 Ubiquilin-4 Ubqln4 363.6 342.3 324.2 330.5 351.3 354.5 0.994017176493293 0.886964818090451 -0.00865731329337066 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) ubiquilin -- ko04141 Protein processing in endoplasmic reticulum Ubiquitin-like protein OR Posttranslational modification, protein turnover, chaperones ; General function prediction only ; IPR000626 [Ubiquitin domain] ; IPR015940[Ubiquitin-associated domain] -- -- B2RY30 Exosome complex component RRP45 Exosc9 717.8 639 585.5 605.7 600.2 608.2 1.07066865112177 0.38181995022925 0.0985120661324032 Nonsignificant None -- -- exosome complex component RRP45 -- ko03018 RNA degradation Exosomal 3'-5' exoribonuclease complex, subunit Rrp45 J Translation, ribosomal structure and biogenesis ; IPR001247 [Exoribonuclease, phosphorolytic domain 1] ; IPR015847[Exoribonuclease, phosphorolytic domain 2] -- -- Q9CY73 39S ribosomal protein L44, mitochondrial Mrpl44 469.9 427 453.1 471.8 591.6 492.7 0.867553499132446 0.152918530662577 -0.204975368259039 Nonsignificant None -- -- large subunit ribosomal protein L44 3.1.26.- -- Ribonuclease III domain proteins J Translation, ribosomal structure and biogenesis ; -- -- -- F8VQ05 FRY-like transcription coactivator Fryl 465 478.3 589.3 510 461.1 524.5 1.0247392350896 0.792339225351285 0.0352568345060616 Nonsignificant None -- -- -- -- -- Fry-like conserved proteins R General function prediction only ; IPR025481 [Cell morphogenesis protein C-terminal] ; IPR025614[Cell morphogenesis protein N-terminal] ; IPR029473[Cell morphogenesis central region] -- -- P97792 Coxsackievirus and adenovirus receptor homolog Cxadr 923.3 851.1 868.5 893.5 932.9 965.4 0.946665233899276 0.174386025503479 -0.0790737544925785 Nonsignificant None -- -- coxsackievirus and adenovirus receptor -- ko05416 Viral myocarditis -- -- -- IPR013106 [Immunoglobulin V-set domain] ; IPR013151[Immunoglobulin] -- -- Q8CHW4 Translation initiation factor eIF-2B subunit epsilon Eif2b5 754.1 907.2 950.4 792.7 776.7 844.8 1.081807638141 0.355040833732609 0.113443988839248 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) translation initiation factor eIF-2B subunit epsilon -- ko03013 RNA transport Translation initiation factor 2B, epsilon subunit (eIF-2Bepsilon/GCD6) J Translation, ribosomal structure and biogenesis ; IPR001451 [Hexapeptide repeat] ; IPR003307[W2 domain] -- -- Q91Z31 Polypyrimidine tract-binding protein 2 Ptbp2 84.9 100.6 126.7 116.8 99 108.5 0.962688868331792 0.77568606544041 -0.0548584864778976 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) polypyrimidine tract-binding protein 2 -- -- Polypyrimidine tract-binding protein A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- G3UZM9 Protein kinase C Pkn2 595.6 576.3 729.7 615.9 668.5 625.3 0.995758496098864 0.960228185543142 -0.00613221075493719 Nonsignificant None 5 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468),Biological Process:signal transduction (GO:0007165) protein kinase N 2.7.11.13 ko04151 PI3K-Akt signaling pathway ko05132 Salmonella infection Serine/threonine protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR011072[HR1 rho-binding repeat] ; IPR017892[Protein kinase, C-terminal] -- -- Q8K3X4 Probable E3 ubiquitin-protein ligase IRF2BPL Irf2bpl 708.8 672.3 577.8 647.4 625.6 656.2 1.01539498237611 0.817054579612124 0.022041036049798 Nonsignificant None -- -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR022750 [Interferon regulatory factor 2-binding protein 1 & 2, zinc finger] -- -- Q9D8H5 Peptidase S1 domain-containing protein Prss32 806.5 731.4 861.6 775.8 681.4 859.4 1.03578520245187 0.687147347390265 0.0507248529405422 Nonsignificant None 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) -- -- -- Trypsin E Amino acid transport and metabolism ; IPR001254 [Serine proteases, trypsin domain] -- -- Q3UXF7 Uncharacterized protein (Fragment) Scfd2 448.9 429 388 400.1 400 419 1.03838897547371 0.45792492334205 0.054346971506471 Nonsignificant None 2 Biological Process:vesicle docking involved in exocytosis (GO:0006904),Biological Process:vesicle-mediated transport (GO:0016192) -- -- -- -- -- -- IPR001619 [Sec1-like protein] -- -- Q7JJ13 Bromodomain-containing protein 2 Brd2 674.5 674.3 650.9 579.6 599.7 579.3 1.13709769134539 0.00147776483114963 0.185356205650676 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) bromodomain-containing protein 2 -- -- Transcription initiation factor TFIID, subunit BDF1 and related bromodomain proteins K Transcription ; IPR001487 [Bromodomain] ; IPR027353[NET domain] -- -- J3QN89 Angio-associated migratory protein Aamp 591.2 627.7 585.8 538.3 536.4 529.5 1.12498441590824 0.00761298451565369 0.169905016333314 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Angio-associated migratory cell protein (contains WD40 repeats) S Function unknown ; IPR001680 [WD40 repeat] -- -- Q8VCN0 Angiotensinogen Agt 646.3 624.5 545.7 361.9 376.1 348 1.67265193370166 0.00152882060993886 0.742137262611123 Significant up -- -- angiotensinogen -- ko04614 Renin-angiotensin system ko04924 Renin secretion Serpin V Defense mechanisms ; IPR023796 [Serpin domain] -- -- Q60866 Phosphotriesterase-related protein Pter 445.8 431.4 462.4 627.1 575.6 621.7 0.7342688007016 0.000973026654132901 -0.445619794151039 Nonsignificant None 2 Molecular Function:zinc ion binding (GO:0008270),Biological Process:catabolic process (GO:0009056) phosphotriesterase-related protein -- -- -- -- -- IPR001559 [Phosphotriesterase] -- -- Q9JJH1 Ribonuclease 4 Rnase4 905.2 927 853.9 847.5 863.9 863.2 1.04330769828323 0.171193704099889 0.0611647084999808 Nonsignificant None -- -- ribonuclease 4 3.1.27.- -- -- -- -- IPR023412 [Ribonuclease A-domain] -- -- Q80WR0 Nucleoporin 153 Nup153 544.7 571.1 470.4 429.9 475.3 450 1.17045454545455 0.0792362198851962 0.227068908545921 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) nuclear pore complex protein Nup153 -- ko03013 RNA transport Nuclear pore complex protein YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; IPR001876 [Zinc finger, RanBP2-type] ; IPR013913[Nucleoporin Nup153, N-terminal] ; IPR018892[Retro-transposon transporting motif] -- -- Q9ESP1 Stromal cell-derived factor 2-like protein 1 Sdf2l1 86.7 231.2 270.1 260.7 260 171.9 0.84897487727404 0.610004725080099 -0.236206232473502 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) -- -- -- Uncharacterized secreted protein SDF2 (Stromal cell-derived factor 2), contains MIR domains R General function prediction only ; IPR016093 [MIR motif] -- -- Q9Z1R9 Protease, serine 1 (trypsin 1) Prss1 133.1 104.6 99.2 105.4 140.6 113 0.938440111420613 0.649041773342092 -0.0916634155886564 Nonsignificant None 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) -- -- -- Trypsin E Amino acid transport and metabolism ; IPR001254 [Serine proteases, trypsin domain] -- -- Q9D1M4 Eukaryotic translation elongation factor 1 epsilon-1 Eef1e1 1437.1 1358.7 1210.3 1050.2 1091.1 1048.4 1.25594883531367 0.0160634886038087 0.328777693096772 Nonsignificant None -- -- eukaryotic translation elongation factor 1 epsilon-1 -- -- Glutathione S-transferase O Posttranslational modification, protein turnover, chaperones ; IPR004046 [Glutathione S-transferase, C-terminal] -- -- Q3UFY8 tRNA methyltransferase 10 homolog C Trmt10c 599.8 555.7 503.3 526.9 571.9 569.2 0.994484412470024 0.92705447735666 -0.00797933642606431 Nonsignificant None -- -- mitochondrial ribonuclease P protein 1 2.1.1.- -- Uncharacterized conserved protein S Function unknown ; IPR016009 [tRNA methyltransferase TRMD/TRM10-type domain] -- -- Q5F2E8 Serine/threonine-protein kinase TAO1 Taok1 211.3 182.2 136.8 163.4 206.1 160.9 0.999811463046757 0.999044830409239 -0.000272026971841857 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) thousand and one amino acid protein kinase 2.7.11.1 ko04010 MAPK signaling pathway Serine/threonine protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q9R126 Eosinophil-associated ribonuclease 7 (Fragment) Ear7 212.6 219.7 300 244.6 258.5 258.4 0.961654629021668 0.749083093891882 -0.0564092408723445 Nonsignificant None -- -- -- -- -- -- -- -- IPR023412 [Ribonuclease A-domain] -- -- Q5SUC9 Protein SCO1 homolog, mitochondrial Sco1 919.3 842.7 921.5 1077.9 1081.4 1023.2 0.843205027494108 0.00655164648512064 -0.246044626015656 Nonsignificant None -- -- protein SCO1/2 -- -- Putative cytochrome C oxidase assembly protein C Energy production and conversion ; IPR003782 [Copper chaperone SCO1/SenC] -- -- Q05DV3 Utp3 protein (Fragment) Utp3 200.9 195.8 181.1 153.1 145.7 147.9 1.29348556077905 0.00230616187770417 0.371263949261359 Nonsignificant None -- -- U3 small nucleolar RNA-associated protein 3 -- -- Disrupter of silencing SAS10 B Chromatin structure and dynamics ; IPR007146 [Sas10/Utp3/C1D] -- -- D3Z4D8 BRISC complex subunit Abraxas 2 (Fragment) Abraxas2 814.1 864.9 907 958 892.4 940.9 0.926450041199441 0.108880804966956 -0.110214913839473 Nonsignificant None -- -- BRISC complex subunit Abro1 -- -- -- -- -- -- -- -- Q80W00 Serine/threonine-protein phosphatase 1 regulatory subunit 10 Ppp1r10 425.2 392.4 540.4 503.9 519.1 473 0.907754010695187 0.382050552930755 -0.139626695642905 Nonsignificant None 2 Cellular Component:nucleus (GO:0005634),Molecular Function:metal ion binding (GO:0046872) protein phosphatase 1 regulatory subunit 10 -- -- -- -- -- IPR000571 [Zinc finger, CCCH-type] ; IPR017923[Transcription factor IIS, N-terminal] -- -- Q9CRD2 ER membrane protein complex subunit 2 Emc2 828.3 829.9 610 628.9 581.3 598.3 1.25418855405032 0.108335460172578 0.326754258462269 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; -- -- -- Q8K212 Phosphofurin acidic cluster sorting protein 1 Pacs1 483.3 548.4 597.6 558.5 547.8 539.8 0.989794058684163 0.875506124746452 -0.0147997125456717 Nonsignificant None -- -- -- -- -- PACS-1 cytosolic sorting protein U Intracellular trafficking, secretion, and vesicular transport ; IPR019381 [Phosphofurin acidic cluster sorting protein 1] -- -- Q9CWY6 RNA-binding protein with multiple-splicing 2 Rbpms2 257.1 219.6 216.8 220 198.5 216 1.0929866036249 0.248488459671317 0.128275718482497 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- RNA binding protein (contains RRM repeats) R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- Q05D94 Cpne8 protein Cpne8 329.7 302.8 331.9 313.2 325.3 322.6 1.00343356570596 0.918098434927755 0.00494510339782134 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Copine T Signal transduction mechanisms ; IPR000008 [C2 domain] ; IPR010734[Copine] -- -- O35114 Lysosome membrane protein 2 Scarb2 1014.6 941.5 1002 848.9 824.9 899.7 1.14944627938605 0.0153017129901785 0.200939041719954 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) lysosome membrane protein 2 -- ko04142 Lysosome Plasma membrane glycoprotein CD36 and related membrane receptors T Signal transduction mechanisms ; IPR002159 [CD36 family] -- -- Q6P2B1 Transportin-3 Tnpo3 903.2 901 841.6 670.8 679.7 684.7 1.30001965408805 0.000586843283451711 0.378533434516056 Nonsignificant None -- -- transportin-3 -- -- Nuclear transport regulator U Intracellular trafficking, secretion, and vesicular transport ; IPR013598 [Exportin-1/Importin-beta-like] -- -- Q9Z0R6 Intersectin-2 Itsn2 281.2 262.2 306.4 278 299.7 291.4 0.977793119318836 0.675618520323856 -0.0323988416782733 Nonsignificant None 3 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Molecular Function:protein binding (GO:0005515),Biological Process:regulation of Rho protein signal transduction (GO:0035023) intersectin -- -- Endocytic adaptor protein intersectin TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR000008 [C2 domain] ; IPR000219[Dbl homology (DH) domain] ; IPR000261[EH domain] ; IPR001452[SH3 domain] ; IPR001849[Pleckstrin homology domain] ; IPR011511[Variant SH3 domain] -- -- Q9CPV3 39S ribosomal protein L42, mitochondrial Mrpl42 415.7 395.3 458.6 411.9 459.8 419.7 0.983119095555211 0.775675313966416 -0.0245618989121674 Nonsignificant None -- -- large subunit ribosomal protein L42 -- -- Uncharacterized conserved protein S Function unknown ; IPR019346 [Ribosomal protein S32, mitochondrial] -- -- Q91V04 Translocating chain-associated membrane protein 1 Tram1 988.5 943.6 803.7 814.3 784 804.7 1.1384935497295 0.120407954984465 0.187126117737498 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) translocating chain-associated membrane protein 1 -- ko04141 Protein processing in endoplasmic reticulum Protein transporter of the TRAM (translocating chain-associating membrane) superfamily U Intracellular trafficking, secretion, and vesicular transport ; IPR006634 [TRAM/LAG1/CLN8 homology domain] ; IPR013599[TRAM1-like protein] -- -- Q3U057 Uncharacterized protein Cpsf3 776.9 1629.7 1018.2 892.9 869.6 823.2 1.32451560505859 0.385307551367836 0.405464841222083 Nonsignificant None -- -- cleavage and polyadenylation specificity factor subunit 3 3.1.27.- ko03015 mRNA surveillance pathway mRNA cleavage and polyadenylation factor II complex, BRR5 (CPSF subunit) A RNA processing and modification ; IPR001279 [Metallo-beta-lactamase] ; IPR011108[Zn-dependent metallo-hydrolase, RNA specificity domain] ; IPR021718[Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term] ; IPR022712[Beta-Casp domain] -- -- B2RY19 Cgnl1 protein Cgnl1 353.3 387.9 408.6 421.5 450.8 381.1 0.917344822083932 0.252592081525259 -0.124463962374761 Nonsignificant None 2 Molecular Function:motor activity (GO:0003774),Cellular Component:myosin complex (GO:0016459) cingulin-like protein 1 -- ko04530 Tight junction -- -- -- IPR002928 [Myosin tail] -- -- Q3UJL4 Uncharacterized protein Htatip2 648.3 631.8 632.8 726.4 799.3 711.2 0.85515669006214 0.0175771352913919 -0.225739306158696 Nonsignificant None -- -- oxidoreductase 1.1.1.- -- Serine/threonine kinase TIP30/CC3 T Signal transduction mechanisms ; -- -- -- Q9R0L6 Pericentriolar material 1 protein Pcm1 699.9 750.9 730.6 614.2 661.7 626.9 1.14641580828253 0.010624173133511 0.197130408618461 Nonsignificant None -- -- pericentriolar material 1 protein -- -- -- -- -- IPR031446 [Pericentriolar material 1 protein, C-terminal] -- -- H3BLI9 TSC22 domain family protein 1 Tsc22d1 460.5 483.7 468.2 518 583.3 517.7 0.872390364422483 0.0394446877734544 -0.196954259430328 Nonsignificant None -- -- -- -- -- Transcriptional regulator K Transcription ; IPR000580 [TSC-22 / Dip / Bun] -- TSC22 Q3TPN9 I-kappa-B kinase Chuk 193.5 191 195.9 161 157.9 184.9 1.15204446208813 0.0418490136588145 0.204196397332503 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) inhibitor of nuclear factor kappa-B kinase subunit alpha 2.7.11.10 ko01523 Antifolate resistance ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04062 Chemokine signaling pathway ko04064 NF-kappa B signaling pathway ko04068 FoxO signaling pathway ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04210 Apoptosis ko04380 Osteoclast differentiation ko04620 Toll-like receptor signaling pathway ko04621 NOD-like receptor signaling pathway ko04622 RIG-I-like receptor signaling pathway ko04623 Cytosolic DNA-sensing pathway ko04657 IL-17 signaling pathway ko04658 Th1 and Th2 cell differentiation ko04659 Th17 cell differentiation ko04660 T cell receptor signaling pathway ko04662 B cell receptor signaling pathway ko04668 TNF signaling pathway ko04920 Adipocytokine signaling pathway ko05142 Chagas disease (American trypanosomiasis) ko05145 Toxoplasmosis ko05160 Hepatitis C ko05161 Hepatitis B ko05162 Measles ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05212 Pancreatic cancer ko05215 Prostate cancer ko05220 Chronic myeloid leukemia ko05221 Acute myeloid leukemia ko05222 Small cell lung cancer ko05418 Fluid shear stress and atherosclerosis TANK binding protein kinase TBK1 T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q546B3 DNA-binding protein SATB Satb2 506.2 485.3 392.6 496.6 483.4 478.4 0.949053757542512 0.552928475977399 -0.0754382863096343 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) -- -- -- SATB1 matrix attachment region binding protein K Transcription ; IPR001356 [Homeobox domain] ; IPR003350[CUT domain] ; IPR032355[SATB, CUT1-like DNA-binding domain] ; IPR032392[SATB, ubiquitin-like oligomerisation domain] -- CUT A2AHJ7 Diacylglycerol kinase Dgkz 304.7 265.9 235.2 252.6 231.5 257.5 1.08656957928803 0.378540800882122 0.119780561523068 Nonsignificant None 4 Molecular Function:diacylglycerol kinase activity (GO:0004143),Biological Process:protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205),Molecular Function:kinase activity (GO:0016301),Biological Process:intracellular signal transduction (GO:0035556) diacylglycerol kinase (ATP) 2.7.1.107 ko00561 Glycerolipid metabolism ko00564 Glycerophospholipid metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system ko04072 Phospholipase D signaling pathway ko05231 Choline metabolism in cancer Predicted diacylglycerol kinase T Signal transduction mechanisms ; IPR000756 [Diacylglycerol kinase, accessory domain] ; IPR001206[Diacylglycerol kinase, catalytic domain] ; IPR002219[Protein kinase C-like, phorbol ester/diacylglycerol-binding domain] ; IPR020683[Ankyrin repeat-containing domain] -- -- O09111 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial Ndufb11 500.5 521.1 570.9 689.3 715.6 675.4 0.765514589241936 0.00247412254079566 -0.385498221895905 Nonsignificant None -- -- NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 11 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Uncharacterized conserved protein S Function unknown ; IPR019329 [NADH:ubiquinone oxidoreductase, ESSS subunit] -- -- Q8C2E6 Monocarboxylate transporter 1 Slc16a1 537.6 536.7 800.1 1059.4 957.9 937.2 0.634422068031816 0.0195630589016736 -0.656485139598415 Significant down 2 Cellular Component:integral component of membrane (GO:0016021),Biological Process:transmembrane transport (GO:0055085) MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 1 -- -- Monocarboxylate transporter G Carbohydrate transport and metabolism ; IPR011701 [Major facilitator superfamily] -- -- P09036 Serine protease inhibitor Kazal-type 1 Spink1 803.1 682.2 777.6 1174.8 1512.1 1367.8 0.558093077169704 0.00462071477112037 -0.841422344207545 Significant down 1 Molecular Function:protein binding (GO:0005515) -- -- -- FOG: Kazal-type serine protease inhibitor domain R General function prediction only ; IPR002350 [Kazal domain] -- -- Q3UA06 Pachytene checkpoint protein 2 homolog Trip13 692.6 709.9 617.4 600 587 613.7 1.12173043816294 0.0679535115944277 0.165726025100596 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) AAA+-type ATPase O Posttranslational modification, protein turnover, chaperones ; IPR003959 [ATPase, AAA-type, core] -- -- Q497T6 COMM domain containing 2 Commd2 570.1 525.6 542.4 561.3 600.6 588.2 0.936003656933889 0.0985099639716863 -0.0954139285080833 Nonsignificant None -- -- -- -- -- IPR017920 [COMM domain] -- -- Q61129 Complement factor I Cfi 1143.4 1272.2 745.7 529.2 599.1 579.3 1.85131178261888 0.0899251160942927 0.888547882436774 Nonsignificant None 5 Molecular Function:serine-type endopeptidase activity (GO:0004252),Molecular Function:scavenger receptor activity (GO:0005044),Molecular Function:protein binding (GO:0005515),Biological Process:proteolysis (GO:0006508),Cellular Component:membrane (GO:0016020) complement factor I 3.4.21.45 ko04610 Complement and coagulation cascades ko05150 Staphylococcus aureus infection Trypsin E Amino acid transport and metabolism ; IPR001190 [SRCR domain] ; IPR001254[Serine proteases, trypsin domain] ; IPR002172[Low-density lipoprotein (LDL) receptor class A repeat] ; IPR002350[Kazal domain] -- -- Q3V1L7 GDP-fucose protein O-fucosyltransferase 2 Pofut2 921.5 945.8 1078.7 1006 960.7 1029.1 0.983376727418386 0.769043164595694 -0.0241838821280373 Nonsignificant None -- -- peptide-O-fucosyltransferase 2.4.1.221 ko00514 Other types of O-glycan biosynthesis -- -- -- IPR019378 [GDP-fucose protein O-fucosyltransferase] -- -- E9QP56 Apolipoprotein C-III Apoc3 727.2 827.1 579.5 471.6 502.9 539.9 1.40900686740623 0.0504107512042687 0.494678643264847 Nonsignificant None 4 Cellular Component:extracellular region (GO:0005576),Biological Process:lipid transport (GO:0006869),Molecular Function:lipid binding (GO:0008289),Biological Process:lipoprotein metabolic process (GO:0042157) apolipoprotein C-III -- ko03320 PPAR signaling pathway ko04979 Cholesterol metabolism -- -- -- IPR008403 [Apolipoprotein CIII] -- -- Q9DAK9 14 kDa phosphohistidine phosphatase Phpt1 1055.5 1005.7 1038.8 958.6 1019.4 1112.8 1.00297657564385 0.951284431157084 0.00428791243355818 Nonsignificant None -- -- phosphohistidine phosphatase 3.9.1.3 -- -- -- -- IPR007702 [Janus] -- -- Q9DCE5 p21-activated protein kinase-interacting protein 1 Pak1ip1 489 457.9 355.3 311.8 309.9 340.9 1.3527945148556 0.052997762658836 0.435942715210424 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) protein MAK11 -- -- WD40 repeat-containing protein S Function unknown ; IPR001680 [WD40 repeat] -- -- Q8BMZ5 tRNA-splicing endonuclease subunit Sen34 Tsen34 243.3 225.4 239.6 208.6 219.5 230.6 1.0752998330044 0.119520003150747 0.104738992163658 Nonsignificant None 1 Molecular Function:tRNA-intron endonuclease activity (GO:0000213) tRNA-splicing endonuclease subunit Sen34 3.1.27.9 -- tRNA splicing endonuclease J Translation, ribosomal structure and biogenesis ; IPR006677 [tRNA intron endonuclease, catalytic domain-like] -- -- F8VQ75 Kinesin-like protein KIF13A Kif13a 315 330.2 170.6 251.4 264.4 268.4 1.04029584289722 0.855469214938143 0.0569938652759339 Nonsignificant None 4 Molecular Function:microtubule motor activity (GO:0003777),Molecular Function:ATP binding (GO:0005524),Biological Process:microtubule-based movement (GO:0007018),Molecular Function:microtubule binding (GO:0008017) kinesin family member 13 -- -- Kinesin-like protein Z Cytoskeleton ; IPR001752 [Kinesin motor domain] ; IPR022140[Kinesin-like KIF1-type] ; IPR022164[Kinesin-like] ; IPR032405[Kinesin-associated] -- -- P83870 PHD finger-like domain-containing protein 5A Phf5a 856.5 939 998.2 945 965.5 882.2 1.00035807641351 0.994805525744858 0.000516502597844328 Nonsignificant None -- -- PHD finger-like domain-containing protein 5A -- ko03040 Spliceosome Uncharacterized conserved protein, contains CXXC motifs S Function unknown ; IPR005345 [PHF5-like] -- -- P26618 Platelet-derived growth factor receptor alpha Pdgfra 106.5 170 171.4 176.1 195.8 159.7 0.84255079006772 0.306359623291623 -0.247164438420477 Nonsignificant None 2 Molecular Function:protein kinase activity (GO:0004672),Biological Process:protein phosphorylation (GO:0006468) platelet-derived growth factor receptor alpha 2.7.10.1 ko01521 EGFR tyrosine kinase inhibitor resistance ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04020 Calcium signaling pathway ko04060 Cytokine-cytokine receptor interaction ko04072 Phospholipase D signaling pathway ko04144 Endocytosis ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04540 Gap junction ko04630 Jak-STAT signaling pathway ko04810 Regulation of actin cytoskeleton ko05166 HTLV-I infection ko05200 Pathways in cancer ko05206 MicroRNAs in cancer ko05214 Glioma ko05215 Prostate cancer ko05218 Melanoma ko05230 Central carbon metabolism in cancer ko05231 Choline metabolism in cancer Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases T Signal transduction mechanisms ; IPR001245 [Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR013098[Immunoglobulin I-set] -- -- Q8BFW4 Tripartite motif-containing protein 65 Trim65 118.2 98.5 104.1 90.4 92.2 106.1 1.1111880845168 0.235893497956008 0.152103034218938 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) tripartite motif-containing protein 65 -- -- -- -- -- IPR003877 [SPRY domain] -- -- Q9CS00 Cactin Cactin 521 529.2 489.1 434.1 455.4 467 1.13475856984888 0.0173415415969437 0.182385383743344 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Cactin T Signal transduction mechanisms ; IPR018816 [Cactin, central domain] ; IPR019134[Cactin, C-terminal] -- -- Q3TPE9 Ankyrin repeat and MYND domain-containing protein 2 Ankmy2 689.1 624.5 620.1 591.7 554.6 623.1 1.09285633548095 0.140172381807289 0.128103759919401 Nonsignificant None -- -- -- -- -- MYND Zn-finger and ankyrin repeat protein R General function prediction only ; IPR002893 [Zinc finger, MYND-type] ; IPR020683[Ankyrin repeat-containing domain] -- -- B2RUR6 Receptor protein-tyrosine kinase Mst1r 496.6 487 403.3 479.9 505.8 439.6 0.973058303515049 0.735528134984738 -0.0394018441749025 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein binding (GO:0005515),Biological Process:protein phosphorylation (GO:0006468) macrophage-stimulating 1 receptor 2.7.10.1 -- Plexins (functional semaphorin receptors) T Signal transduction mechanisms ; IPR001245 [Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR001627[Sema domain] ; IPR002909[IPT domain] -- -- Q61151 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Ppp2r5e 794.1 771.6 820.7 794.2 847.3 820.1 0.969450763730907 0.296368864644163 -0.0447604659983322 Nonsignificant None 3 Cellular Component:protein phosphatase type 2A complex (GO:0000159),Biological Process:signal transduction (GO:0007165),Molecular Function:protein phosphatase regulator activity (GO:0019888) serine/threonine-protein phosphatase 2A regulatory subunit B' -- ko03015 mRNA surveillance pathway ko04071 Sphingolipid signaling pathway ko04114 Oocyte meiosis ko04151 PI3K-Akt signaling pathway ko04152 AMPK signaling pathway ko04261 Adrenergic signaling in cardiomyocytes ko04728 Dopaminergic synapse ko05165 Human papillomavirus infection Serine/threonine protein phosphatase 2A, regulatory subunit T Signal transduction mechanisms ; IPR002554 [Protein phosphatase 2A, regulatory B subunit, B56] -- -- Q8BU03 Periodic tryptophan protein 2 homolog Pwp2 492.7 460.6 414.9 395 400.8 419.2 1.12609053497942 0.0976882521085737 0.17132282130372 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) periodic tryptophan protein 2 -- ko03008 Ribosome biogenesis in eukaryotes WD40-repeat-containing subunit of the 18S rRNA processing complex A RNA processing and modification ; IPR001680 [WD40 repeat] ; IPR007148[Small-subunit processome, Utp12] -- -- Q812G0 Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A Mgat4a 650.6 641 940.5 909.4 886 961.2 0.809729376768483 0.157707595633535 -0.304488275815932 Nonsignificant None 2 Biological Process:carbohydrate metabolic process (GO:0005975),Cellular Component:membrane (GO:0016020) alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase A/B 2.4.1.145 ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways -- -- -- IPR006759 [Glycosyl transferase family 54] -- -- B2RXS1 Nbeal2 protein Nbeal2 517.7 525.6 432.2 460.2 444 502.6 1.04883423372192 0.544619063513829 0.0687866806940626 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Kinase A-anchor protein Neurobeachin and related BEACH and WD40 repeat proteins U Intracellular trafficking, secretion, and vesicular transport ; IPR000409 [BEACH domain] ; IPR001680[WD40 repeat] ; IPR023362[PH-BEACH domain] ; IPR031570[Domain of unknown function DUF4704] -- -- Q8VCC2 Liver carboxylesterase 1 Ces1 62.2 62.8 73.6 86.1 83.9 82.6 0.786223277909739 0.00941486228096332 -0.346989016259178 Nonsignificant None -- -- -- -- -- Carboxylesterase and related proteins R General function prediction only ; IPR002018 [Carboxylesterase, type B] -- -- A0A1D5RLV0 Protein IWS1 homolog Iws1 241 224.2 186.8 182 198 203 1.11835334476844 0.252711115594608 0.161376081030581 Nonsignificant None 1 Cellular Component:nucleus (GO:0005634) transcription factor SPN1 -- -- Uncharacterized conserved protein S Function unknown ; IPR017923 [Transcription factor IIS, N-terminal] -- -- Q2TBE6 Phosphatidylinositol 4-kinase type 2-alpha Pi4k2a 401.7 395.2 450.9 415.8 438.1 420.6 0.979050608081601 0.661333308129279 -0.030544658816012 Nonsignificant None 1 Molecular Function:kinase activity (GO:0016301) phosphatidylinositol 4-kinase type 2 2.7.1.67 ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system Phosphatidylinositol 4-kinase T Signal transduction mechanisms ; IPR000403 [Phosphatidylinositol 3-/4-kinase, catalytic domain] -- -- Q0GUM3 Interferon-gamma-inducible p47 GTPase Gm12250 469.4 493 528.9 493.4 599.3 567.7 0.898157070585401 0.190877316322643 -0.154960327939844 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Cellular Component:membrane (GO:0016020) -- -- -- -- -- -- IPR007743 [Immunity-related GTPases-like] -- -- A0A0A0MQ80 Vesicle-fusing ATPase Spata5 36 35.3 33.8 24 26.1 23.1 1.43579234972678 0.000641871822941117 0.521847115678136 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) AAA family ATPase -- ko03008 Ribosome biogenesis in eukaryotes AAA+-type ATPase O Posttranslational modification, protein turnover, chaperones ; IPR003959 [ATPase, AAA-type, core] -- -- Q8K4X7 1-acyl-sn-glycerol-3-phosphate acyltransferase delta Agpat4 757.1 816.9 1053.1 1168.4 1107.5 936.4 0.817825234255829 0.16213396236281 -0.290135516525297 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) -- -- ko00561 Glycerolipid metabolism ko00564 Glycerophospholipid metabolism ko01100 Metabolic pathways ko04072 Phospholipase D signaling pathway Lysophosphatidic acid acyltransferase LPAAT and related acyltransferases I Lipid transport and metabolism ; IPR002123 [Phospholipid/glycerol acyltransferase] ; IPR032098[Acyltransferase, C-terminal domain] -- -- Q8BZS9 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 Dhx32 579.2 580.1 655.6 626.7 635.9 580.9 0.98448603200434 0.770231292671665 -0.0225573577305953 Nonsignificant None 1 Molecular Function:helicase activity (GO:0004386) pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 3.6.4.13 -- mRNA splicing factor ATP-dependent RNA helicase A RNA processing and modification ; IPR007502 [Helicase-associated domain] ; IPR011709[Domain of unknown function DUF1605] -- -- A2AFS3 Endosome/lysosome-associated apoptosis and autophagy regulator 1 Elapor1 604 590.7 793.8 826.3 714.3 806.7 0.847143526605036 0.181962149872639 -0.239321677184186 Nonsignificant None -- -- -- -- -- Fibrillins and related proteins containing Ca2+-binding EGF-like domains T Signal transduction mechanisms ; -- -- -- Q3UHJ0 AP2-associated protein kinase 1 Aak1 393.1 409.4 448.1 429 455.2 492.3 0.90853614239012 0.162690064044847 -0.138384187571789 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) AP2-associated kinase 2.7.11.1 -- ARK protein kinase family T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q9CQN3 Mitochondrial import receptor subunit TOM6 homolog Tomm6 570.8 556.4 495.4 684.9 597.8 568.8 0.876370510396975 0.142324517644931 -0.190387155994916 Nonsignificant None 1 Cellular Component:mitochondrial outer membrane translocase complex (GO:0005742) mitochondrial import receptor subunit TOM6 -- -- -- -- -- IPR029182 [Mitochondrial import receptor subunit TOM6 homologue] -- -- Q0VEW4 Proteolipid protein 2 Plp2 659.5 654.4 530.5 568 572.4 654.7 1.02746365105008 0.762226372298324 0.0390873560700907 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) -- -- -- Members of chemokine-like factor super family and related proteins V Defense mechanisms ; IPR008253 [Marvel domain] -- -- Q9DC71 28S ribosomal protein S15, mitochondrial Mrps15 895.2 904 1082.3 1021.9 1031.3 1053.7 0.92745180083041 0.342515591899619 -0.108655787288481 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S15 -- ko03010 Ribosome Mitochondrial/choloroplast ribosomal protein S15 J Translation, ribosomal structure and biogenesis ; IPR000589 [Ribosomal protein S15] -- -- A2AIY3 Insulin-like peptide INSL5 Insl5 1266.7 987.6 806.1 2055.2 2060.3 2182.2 0.485955189989996 0.00153460731577562 -1.04110480607624 Significant down 2 Molecular Function:hormone activity (GO:0005179),Cellular Component:extracellular region (GO:0005576) insulin-like 5 -- ko04926 Relaxin signaling pathway -- -- -- IPR016179 [Insulin-like] -- -- Q99JV5 StAR-related lipid transfer protein 4 Stard4 591.1 535.6 486.6 577.2 621.9 565.6 0.914206380687936 0.219788612180454 -0.129408206644695 Nonsignificant None 1 Molecular Function:lipid binding (GO:0008289) -- -- -- MLN, STAR and related lipid-binding proteins I Lipid transport and metabolism ; IPR002913 [START domain] -- -- Q8BNU0 Armadillo repeat-containing protein 6 Armc6 223 210.1 239.6 250.1 242 231.4 0.929785763648929 0.169268613101077 -0.105029758587732 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR000225 [Armadillo] -- -- Q4FJM2 Cyclin-dependent kinase inhibitor 1B Cdkn1b 672.6 675.2 629.7 590.4 612.7 627.4 1.08030592734226 0.0550061085979785 0.111439921055609 Nonsignificant None 3 Molecular Function:cyclin-dependent protein serine/threonine kinase inhibitor activity (GO:0004861),Cellular Component:nucleus (GO:0005634),Biological Process:cell cycle arrest (GO:0007050) cyclin-dependent kinase inhibitor 1B -- ko01522 Endocrine resistance ko04012 ErbB signaling pathway ko04066 HIF-1 signaling pathway ko04068 FoxO signaling pathway ko04110 Cell cycle ko04151 PI3K-Akt signaling pathway ko04933 AGE-RAGE signaling pathway in diabetic complications ko05161 Hepatitis B ko05162 Measles ko05165 Human papillomavirus infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05202 Transcriptional misregulation in cancer ko05203 Viral carcinogenesis ko05206 MicroRNAs in cancer ko05215 Prostate cancer ko05220 Chronic myeloid leukemia ko05222 Small cell lung cancer ko05226 Gastric cancer Cyclin-dependent kinase inhibitor T Signal transduction mechanisms ; IPR003175 [Cyclin-dependent kinase inhibitor] -- -- Q9WVJ3 Carboxypeptidase Q Cpq 665 654.6 674.2 853.2 930.1 765.9 0.78212772634552 0.0579120915709098 -0.354523866998956 Nonsignificant None -- -- carboxypeptidase Q 3.4.17.- -- Transferrin receptor and related proteins containing the protease-associated (PA) domain OPR Posttranslational modification, protein turnover, chaperones ; Inorganic ion transport and metabolism ; General function prediction only ; IPR007484 [Peptidase M28] -- -- D3Z2K2 28S ribosomal protein S14, mitochondrial Mrps14 457.7 432.1 389.3 416.2 443.3 407.3 1.00970950426271 0.865451423112741 0.0139402860054297 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S14 -- ko03010 Ribosome Mitochondrial/chloroplast ribosomal protein S14/S29 J Translation, ribosomal structure and biogenesis ; IPR001209 [Ribosomal protein S14] -- -- A0A0X1KG67 ER membrane protein complex subunit 10 Emc10 212.2 217.1 221.7 211.5 213.3 212.9 1.02085620197585 0.188091247424844 0.029779662193343 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; -- -- -- O54692 Centromere/kinetochore protein zw10 homolog Zw10 238.9 209.4 238.5 224.1 226.9 213 1.03433734939759 0.514879512145142 0.0487067977678469 Nonsignificant None 2 Cellular Component:nucleus (GO:0005634),Biological Process:mitotic nuclear division (GO:0007067) protein transport protein DSL1/ZW10 -- -- Centromere/kinetochore protein zw10 involved in mitotic chromosome segregation D Cell cycle control, cell division, chromosome partitioning ; IPR009361 [RZZ complex, subunit Zw10] -- -- Q6GU28 Meis homeobox 2 Meis2 116.7 254.9 336 322.4 295.5 215.8 0.848746551517332 0.588565617065801 -0.23659428723126 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) homeobox protein Meis2 -- -- Transcription factor MEIS1 and related HOX domain proteins K Transcription ; IPR008422 [Homeobox KN domain] ; IPR032453[Homeobox protein PKNOX/Meis, N-terminal] -- Homeobox Q543D7 Uncharacterized protein Fhl2 1077.4 1057.8 1384.5 1118 1144.5 1122.2 1.0398853665022 0.712310763906155 0.0564244992375266 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) four and a half LIM domains protein 2 -- ko04380 Osteoclast differentiation FOG: LIM domain TZR Signal transduction mechanisms ; Cytoskeleton ; General function prediction only ; IPR001781 [Zinc finger, LIM-type] -- -- Q05CC5 Ppig protein (Fragment) Ppig 1104.4 1118.4 1081.2 905.7 997.5 933 1.16493900289119 0.00599628832693134 0.220254416227002 Nonsignificant None 3 Biological Process:protein peptidyl-prolyl isomerization (GO:0000413),Molecular Function:peptidyl-prolyl cis-trans isomerase activity (GO:0003755),Biological Process:protein folding (GO:0006457) peptidyl-prolyl isomerase G (cyclophilin G) 5.2.1.8 -- HSP90 co-chaperone CPR7/Cyclophilin O Posttranslational modification, protein turnover, chaperones ; IPR002130 [Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain] -- -- Q921E6 Polycomb protein EED Eed 541.6 570.1 564.9 578.6 590.8 613.8 0.940219829519964 0.0585112197602153 -0.0889299871610328 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) polycomb protein EED -- -- Transcriptional repressor EED/ESC/FIE, required for transcriptional silencing, WD repeat superfamily K Transcription ; IPR001680 [WD40 repeat] -- -- Q02013 Aquaporin-1 Aqp1 472.1 439.2 482.7 473.4 508.6 529.2 0.922445738485971 0.134980512677748 -0.116464045632584 Nonsignificant None 3 Molecular Function:transporter activity (GO:0005215),Biological Process:transport (GO:0006810),Cellular Component:membrane (GO:0016020) aquaporin-1 -- ko04924 Renin secretion ko04964 Proximal tubule bicarbonate reclamation ko04976 Bile secretion Aquaporin (major intrinsic protein family) G Carbohydrate transport and metabolism ; IPR000425 [Major intrinsic protein] -- -- Q8VC03 Echinoderm microtubule-associated protein-like 3 Eml3 337.3 300.8 367.9 347.6 348.9 336.9 0.973485581575382 0.668015110196678 -0.0387684837319709 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) echinoderm microtubule-associated protein-like 3 -- -- Uncharacterized conserved protein, contains HELP and WD40 domains S Function unknown ; IPR001680 [WD40 repeat] ; IPR005108[HELP] -- -- A0A1L1STZ4 Nitric oxide synthase Nos2 442.1 474.2 292.6 242.8 260.2 234.9 1.63829787234043 0.104518735769602 0.712197689017264 Nonsignificant None 5 Molecular Function:nitric-oxide synthase activity (GO:0004517),Biological Process:nitric oxide biosynthetic process (GO:0006809),Molecular Function:FMN binding (GO:0010181),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) nitric-oxide synthase, inducible 1.14.13.39 ko00220 Arginine biosynthesis ko00330 Arginine and proline metabolism ko01100 Metabolic pathways ko04020 Calcium signaling pathway ko04066 HIF-1 signaling pathway ko04146 Peroxisome ko04371 Apelin signaling pathway ko04926 Relaxin signaling pathway ko05132 Salmonella infection ko05133 Pertussis ko05140 Leishmaniasis ko05142 Chagas disease (American trypanosomiasis) ko05145 Toxoplasmosis ko05146 Amoebiasis ko05152 Tuberculosis ko05200 Pathways in cancer ko05222 Small cell lung cancer NADP/FAD dependent oxidoreductase C Energy production and conversion ; IPR001433 [Oxidoreductase FAD/NAD(P)-binding] ; IPR003097[FAD-binding, type 1] ; IPR004030[Nitric oxide synthase, N-terminal] ; IPR008254[Flavodoxin/nitric oxide synthase] -- -- Q922L6 Negative elongation factor D Nelfcd 955.7 935.9 1004.5 1007.7 932.7 958.8 0.998930739514349 0.974154593730275 -0.00154344211803422 Nonsignificant None 1 Cellular Component:nucleus (GO:0005634) negative elongation factor C/D -- -- -- -- -- IPR006942 [TH1 protein] -- -- P04104 Keratin, type II cytoskeletal 1 Krt1 297.4 137.9 139 661.3 156.2 147.1 0.595376321791416 0.505290803963581 -0.748126248375865 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) type II keratin, basic -- -- -- -- -- IPR001664 [Intermediate filament protein] ; IPR032444[Keratin type II head] ; IPR032449[Keratin type II cytoskeletal 1, tail] -- -- J3QMC5 Midasin Mdn1 705.2 668.1 625.6 574.1 593.6 574.2 1.14754004248235 0.0230544970952429 0.198544496194894 Nonsignificant None 2 Molecular Function:ATP binding (GO:0005524),Molecular Function:ATPase activity (GO:0016887) midasin -- ko03008 Ribosome biogenesis in eukaryotes AAA ATPase containing von Willebrand factor type A (vWA) domain R General function prediction only ; IPR011704 [ATPase, dynein-related, AAA domain] -- -- A0A087WRG0 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 Pfkfb2 410.8 355.9 350.3 341.7 372.8 374.3 1.02590007347539 0.691600880101685 0.0368902138666823 Nonsignificant None 3 Molecular Function:6-phosphofructo-2-kinase activity (GO:0003873),Molecular Function:ATP binding (GO:0005524),Biological Process:fructose metabolic process (GO:0006000) -- -- ko00051 Fructose and mannose metabolism ko04152 AMPK signaling pathway ko04919 Thyroid hormone signaling pathway Fructose-6-phosphate 2-kinase/fructose-2,6-biphosphatase G Carbohydrate transport and metabolism ; IPR013078 [Histidine phosphatase superfamily, clade-1] ; IPR013079[6-phosphofructo-2-kinase] -- -- I6L973 Krtcap3 protein Krtcap3 85.1 86.8 91.2 88.5 76.7 79.8 1.07387755102041 0.203403086564356 0.102829499275956 Nonsignificant None -- -- -- -- -- -- -- -- IPR020977 [Beta-casein-like] -- -- H7BX88 Carnitine O-acetyltransferase Crat 750.2 773 775.9 875.8 833.9 878.6 0.888266429702894 0.00435901469970089 -0.170935626465482 Nonsignificant None -- -- carnitine O-acetyltransferase 2.3.1.7 ko04146 Peroxisome Carnitine O-acyltransferase CRAT I Lipid transport and metabolism ; IPR000542 [Acyltransferase ChoActase/COT/CPT] -- -- Q68FM7 Rho guanine nucleotide exchange factor (GEF) 11 Arhgef11 139.9 131.3 154.4 194.4 203.5 215.2 0.694177132604795 0.00229392313817699 -0.526624253807578 Nonsignificant None 4 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Molecular Function:protein binding (GO:0005515),Cellular Component:cytoplasm (GO:0005737),Biological Process:regulation of Rho protein signal transduction (GO:0035023) Rho guanine nucleotide exchange factor 11 -- ko04270 Vascular smooth muscle contraction ko05200 Pathways in cancer Predicted guanine nucleotide exchange factor T Signal transduction mechanisms ; IPR000219 [Dbl homology (DH) domain] ; IPR001478[PDZ domain] ; IPR015212[Regulator of G protein signalling-like domain] -- -- Q9DBS2 Tumor protein p63-regulated gene 1-like protein Tprg1l 416.2 435 436.3 437 432.8 453.3 0.973093492555362 0.258405806926084 -0.0393496724439396 Nonsignificant None -- -- -- -- -- -- -- -- IPR022158 [Inositol phosphatase] -- -- Q6P9Z1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 Smarcd3 25.6 29 23.4 19.9 26.3 27.3 1.06122448979592 0.624516009698332 0.085729874025884 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D -- ko05225 Hepatocellular carcinoma SWI/SNF transcription activation complex subunit BK Chromatin structure and dynamics ; Transcription ; IPR003121 [SWIB/MDM2 domain] -- -- P62313 U6 snRNA-associated Sm-like protein LSm6 Lsm6 1833.8 1936.7 2191.7 1862.3 1894.1 1897.2 1.05458468940144 0.435804268836153 0.0766749567469844 Nonsignificant None -- -- U6 snRNA-associated Sm-like protein LSm6 -- ko03018 RNA degradation ko03040 Spliceosome Small nuclear ribonucleoprotein F A RNA processing and modification ; IPR001163 [LSM domain, eukaryotic/archaea-type] -- -- Q921C5 Protein bicaudal D homolog 2 Bicd2 183.9 197.3 215.1 234.9 240.7 206.8 0.873827667057444 0.106581013691562 -0.19457930989412 Nonsignificant None 2 Cellular Component:Golgi apparatus (GO:0005794),Biological Process:transport (GO:0006810) protein bicaudal D -- -- Microtubule-associated protein Bicaudal-D U Intracellular trafficking, secretion, and vesicular transport ; IPR018477 [Bicaudal-D protein, microtubule-associated] -- -- P51569 Alpha-galactosidase A Gla 711.2 663 760 794.2 788.1 747.2 0.916162266580811 0.108849984856037 -0.126324950212813 Nonsignificant None 1 Biological Process:carbohydrate metabolic process (GO:0005975) alpha-galactosidase 3.2.1.22 ko00052 Galactose metabolism ko00561 Glycerolipid metabolism ko00600 Sphingolipid metabolism ko00603 Glycosphingolipid biosynthesis - globo and isoglobo series ko04142 Lysosome Alpha-D-galactosidase (melibiase) G Carbohydrate transport and metabolism ; IPR002241 [Glycoside hydrolase, family 27] -- -- Q8BFQ8 Glutamine amidotransferase-like class 1 domain-containing protein 1 Gatd1 344 351.4 335.7 389.3 407.2 401 0.861043841336117 0.00132564322161935 -0.215841398417452 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- A8DIL0 Galectin Lgals8 368.6 379 397.3 420.9 428.9 406.9 0.911036842524071 0.0243186938194641 -0.134418696785386 Nonsignificant None 1 Molecular Function:carbohydrate binding (GO:0030246) galectin-8 -- -- Galectin, galactose-binding lectin W Extracellular structures ; IPR001079 [Galectin, carbohydrate recognition domain] -- -- Q924Z4 Ceramide synthase 2 Cers2 643.6 667.9 540.7 522.9 532.3 503.1 1.1886029647693 0.0701591512103999 0.24926688462474 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Cellular Component:integral component of membrane (GO:0016021) ceramide synthetase 2.3.1.24 ko00600 Sphingolipid metabolism ko01100 Metabolic pathways ko04071 Sphingolipid signaling pathway Protein transporter of the TRAM (translocating chain-associating membrane) superfamily U Intracellular trafficking, secretion, and vesicular transport ; IPR001356 [Homeobox domain] ; IPR006634[TRAM/LAG1/CLN8 homology domain] -- Homeobox A0A0R4J0J8 Cytospin-A Specc1l 463.2 450.1 492.4 538.1 525 539.1 0.877356135313943 0.00790623353043447 -0.188765516347622 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- FOG: Calponin homology domain R General function prediction only ; IPR001715 [Calponin homology domain] -- -- Q8CEC6 Peptidylprolyl isomerase domain and WD repeat-containing protein 1 Ppwd1 817.2 829.6 801.5 765.7 807.8 887.6 0.994799073584982 0.912954563171287 -0.00752293085382764 Nonsignificant None 4 Biological Process:protein peptidyl-prolyl isomerization (GO:0000413),Molecular Function:peptidyl-prolyl cis-trans isomerase activity (GO:0003755),Molecular Function:protein binding (GO:0005515),Biological Process:protein folding (GO:0006457) peptidylprolyl isomerase domain and WD repeat-containing protein 1 5.2.1.8 -- Cyclophilin-related peptidyl-prolyl cis-trans isomerase O Posttranslational modification, protein turnover, chaperones ; IPR001680 [WD40 repeat] ; IPR002130[Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain] -- -- P62311 U6 snRNA-associated Sm-like protein LSm3 Lsm3 270.9 305.3 331.9 320.1 315.6 266.6 1.00642801728915 0.941139478709863 0.00924399012941427 Nonsignificant None -- -- U6 snRNA-associated Sm-like protein LSm3 -- ko03018 RNA degradation ko03040 Spliceosome Small nuclear ribonucleoprotein (snRNP) LSM3 A RNA processing and modification ; IPR001163 [LSM domain, eukaryotic/archaea-type] -- -- P97364 Selenide, water dikinase 2 Sephs2 353.8 342.5 388.8 443.1 422.5 436.2 0.833538177907513 0.00894635901154378 -0.262679815511965 Nonsignificant None -- -- selenide, water dikinase 2.7.9.3 ko00450 Selenocompound metabolism ko01100 Metabolic pathways Selenophosphate synthetase T Signal transduction mechanisms ; IPR010918 [AIR synthase-related protein, C-terminal domain] ; IPR016188[PurM-like, N-terminal domain] -- -- Q5SVF7 NIPSNAP domain-containing protein Nipsnap1 1445.7 1377.4 1599.9 1689.5 1579.1 1856.6 0.862990712557559 0.0877946517514162 -0.212583061577282 Nonsignificant None -- -- -- -- -- NIPSNAP1 protein S Function unknown ; IPR012577 [NIPSNAP] -- -- Q8R0A0 General transcription factor IIF subunit 2 Gtf2f2 473.5 508.6 493.7 466.9 524.2 457.5 1.01877674996548 0.715784611674238 0.026837940605937 Nonsignificant None 3 Cellular Component:transcription factor TFIIF complex (GO:0005674),Biological Process:transcription from RNA polymerase II promoter (GO:0006366),Biological Process:transcription initiation from RNA polymerase II promoter (GO:0006367) transcription initiation factor TFIIF subunit beta 3.6.4.12 ko03022 Basal transcription factors Transcription initiation factor IIF, small subunit (RAP30) K Transcription ; IPR003196 [Transcription initiation factor IIF, beta subunit] -- -- A0A5H1ZRL7 Transformation-related protein 53-binding protein 1 Trp53bp1 587 622.2 340.4 308.3 306.4 339.1 1.62465925770602 0.152578690325466 0.700137171208896 Nonsignificant None -- -- tumor suppressor p53-binding protein 1 -- ko04621 NOD-like receptor signaling pathway DNA damage checkpoint protein RHP9/CRB2/53BP1 L Replication, recombination and repair ; IPR015125 [Tumour suppressor p53-binding protein-1 Tudor domain] -- -- G3X9J0 Signal-induced proliferation-associated 1-like protein 3 Sipa1l3 241.7 226.7 269.8 283.9 279.7 278.8 0.87630579297246 0.108552607822053 -0.190493698780108 Nonsignificant None 2 Molecular Function:GTPase activator activity (GO:0005096),Biological Process:regulation of small GTPase mediated signal transduction (GO:0051056) signal-induced proliferation-associated 1 like protein 3 -- ko04015 Rap1 signaling pathway Rap1-GTPase-activating protein (Rap1GAP) T Signal transduction mechanisms ; IPR000331 [Rap GTPase activating protein domain] ; IPR021818[Signal-induced proliferation-associated 1-like protein, C-terminal] -- -- A0A087WQH8 Probable UDP-sugar transporter protein SLC35A4 Slc35a4 851 823.3 783 783.4 797.1 744.1 1.05708508990794 0.155795355463984 0.0800915109186646 Nonsignificant None -- -- -- -- -- -- -- -- IPR027854 [Protein of unknown function DUF4535] -- -- Q9D1C1 Ubiquitin-conjugating enzyme E2 C Ube2c 405.1 415.2 359.7 302.4 307.8 317.1 1.27251159279629 0.00873575236321011 0.347678799557186 Nonsignificant None -- -- ubiquitin-conjugating enzyme E2 C 2.3.2.23 ko04120 Ubiquitin mediated proteolysis Ubiquitin-protein ligase O Posttranslational modification, protein turnover, chaperones ; IPR000608 [Ubiquitin-conjugating enzyme E2] -- -- P49710 Hematopoietic lineage cell-specific protein Hcls1 1014.9 1267.4 1029.8 971.8 1042 967.4 1.11099557225278 0.265570864060209 0.151853067040524 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) cortactin -- ko04530 Tight junction ko05100 Bacterial invasion of epithelial cells ko05205 Proteoglycans in cancer -- -- -- IPR001452 [SH3 domain] ; IPR003134[Hs1/Cortactin] -- -- Q9JKL4 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 Ndufaf3 456 430.3 408.8 477.7 490.2 426.1 0.929053084648493 0.239814880118069 -0.106167062573175 Nonsignificant None -- -- -- -- -- Uncharacterized conserved nuclear protein S Function unknown ; IPR007523 [NDUFAF3/Mth938 domain-containing protein] -- -- J3QK52 Nucleolar complex protein 2 homolog Noc2l 66.2 111.8 125.8 102.4 126.2 100.9 0.922003034901366 0.687148227096746 -0.117156595393331 Nonsignificant None -- -- nucleolar complex protein 2 -- -- Predicted protein involved in nuclear export of pre-ribosomes J Translation, ribosomal structure and biogenesis ; IPR005343 [Nucleolar complex protein 2] -- -- Q9CZZ8 Uncharacterized protein Angptl2 168.8 163.3 168.4 176.1 177 205.9 0.895348837209302 0.121462671246701 -0.159478214007197 Nonsignificant None -- -- -- -- -- Ficolin and related extracellular proteins R General function prediction only ; -- -- -- P97369 Neutrophil cytosol factor 4 Ncf4 432.3 540.7 466 373.9 395.4 372.1 1.26073243385316 0.0393226623914456 0.33426212395121 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:phosphatidylinositol binding (GO:0035091) neutrophil cytosolic factor 4 -- ko04145 Phagosome ko04380 Osteoclast differentiation ko04670 Leukocyte transendothelial migration ko05140 Leishmaniasis NADPH oxidase C Energy production and conversion ; IPR000270 [PB1 domain] ; IPR001452[SH3 domain] ; IPR001683[Phox homologous domain] -- -- A2RRR3 Clasp2 protein Clasp2 138 148.2 153 142.5 147.9 145.3 1.00803305026394 0.815779189137595 0.0115429410900307 Nonsignificant None -- -- CLIP-associating protein 1/2 -- -- CLIP-associating protein R General function prediction only ; IPR024395 [CLASP N-terminal domain] -- -- Q496S6 Aven protein Aven 301.1 275.1 206.9 212.5 227.8 249.9 1.13459866705303 0.361900263449618 0.182182074218317 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- B6YY24 Skeletal muscle cells re-entry induced Fam91a1 101.1 109.2 147 129.8 139.3 121.9 0.913810741687979 0.495892781258584 -0.130032693609445 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR028091 [FAM91, N-terminal domain] ; IPR028097[FAM91, C-terminal domain] -- -- Q9Z0R9 Acyl-CoA 6-desaturase Fads2 367.1 420.4 468.2 609.6 656.7 587.2 0.677475047207985 0.005034343436712 -0.561760284852221 Nonsignificant None 1 Biological Process:lipid metabolic process (GO:0006629) acyl-CoA 6-desaturase (Delta-6 desaturase) 1.14.19.3 ko00592 alpha-Linolenic acid metabolism ko01040 Biosynthesis of unsaturated fatty acids ko01212 Fatty acid metabolism ko03320 PPAR signaling pathway Delta 6-fatty acid desaturase/delta-8 sphingolipid desaturase I Lipid transport and metabolism ; IPR001199 [Cytochrome b5-like heme/steroid binding domain] ; IPR005804[Fatty acid desaturase domain] -- -- Q91VN4 MICOS complex subunit Mic25 Chchd6 430 505.1 656.1 710.5 706 637.2 0.774796708379997 0.0943193146036678 -0.368110270029755 Nonsignificant None -- -- coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial -- -- Head-elevated expression protein K Transcription ; IPR007964 [Protein of unknown function DUF737] -- -- Q8BTY1 Kynurenine--oxoglutarate transaminase 1 Kyat1 247.4 253.7 282.4 426.4 444.4 419 0.607458520700884 0.000212445444991504 -0.719142194847451 Significant down 2 Biological Process:biosynthetic process (GO:0009058),Molecular Function:pyridoxal phosphate binding (GO:0030170) -- -- ko00380 Tryptophan metabolism ko00450 Selenocompound metabolism ko01100 Metabolic pathways ko05204 Chemical carcinogenesis Kynurenine aminotransferase, glutamine transaminase K E Amino acid transport and metabolism ; IPR004839 [Aminotransferase, class I/classII] -- -- Q80ZS3 28S ribosomal protein S26, mitochondrial Mrps26 643 638.3 791.6 733.7 760.5 686.2 0.950697119794533 0.5490257337667 -0.0729423051880793 Nonsignificant None 1 Cellular Component:mitochondrial small ribosomal subunit (GO:0005763) small subunit ribosomal protein S26 -- -- Uncharacterized conserved protein S Function unknown ; IPR026140 [28S ribosomal protein S26] -- -- Q9CXG2 Uncharacterized protein Rab22a 293.3 288.4 342.3 307.9 343.2 306.5 0.964912280701754 0.621786390104209 -0.0515303006400821 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-22 -- ko04144 Endocytosis GTPase Rab5/YPT51 and related small G protein superfamily GTPases U Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- Q9D7I5 Phospholysine phosphohistidine inorganic pyrophosphate phosphatase Lhpp 1142.2 1122.3 1313 1020.7 898.1 1085.3 1.19087247428514 0.0794553547362886 0.252018929098809 Nonsignificant None -- -- -- -- ko00190 Oxidative phosphorylation Predicted sugar phosphatase (HAD superfamily) R General function prediction only ; IPR006357 [HAD-superfamily hydrolase, subfamily IIA] -- -- Q9CWN7 CCR4-NOT transcription complex subunit 11 Cnot11 192.3 172.5 183.3 177.1 177 188.1 1.01088159350793 0.786982236460982 0.0156140215109331 Nonsignificant None 1 Cellular Component:CCR4-NOT complex (GO:0030014) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019312 [CCR4-NOT transcription complex subunit 11] -- -- Q3TA40 RIKEN cDNA 6430548M08 gene 6430548M08Rik 848.7 874.5 731.1 608.1 701.4 688.8 1.22819396487014 0.0453985600071084 0.296538419061986 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q8CCH2 NHL repeat-containing protein 3 Nhlrc3 473.9 507.9 608.6 600.6 605.9 576.6 0.891929785205541 0.196021943556091 -0.164997952592553 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR001258 [NHL repeat] -- -- Q3UZA1 CapZ-interacting protein Rcsd1 257.7 268.3 207.7 239.1 242.3 246.7 1.00769125120176 0.929801292228969 0.0110536759495922 Nonsignificant None -- -- CapZ-interacting protein -- -- -- -- -- IPR007850 [RCSD] ; IPR029341[FAM21/CAPZIP domain] -- -- S4R248 Rho GTPase-activating protein 12 Arhgap12 486.6 462.8 470.7 483.2 533.2 483.7 0.946670221985201 0.212607102042067 -0.0790661527896639 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Biological Process:signal transduction (GO:0007165) Rho GTPase-activating protein 12/27 -- -- Predicted Rho GTPase-activating protein T Signal transduction mechanisms ; IPR000198 [Rho GTPase-activating protein domain] ; IPR001202[WW domain] ; IPR001452[SH3 domain] ; IPR001849[Pleckstrin homology domain] -- -- Q99JH1 Ribonuclease P protein subunit p25-like protein Rpp25l 300.8 306.6 257.2 272.7 292 282.3 1.02077922077922 0.740962913794263 0.0296708666763428 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) ribonucleases P/MRP protein subunit RPP25 3.1.26.5 ko03008 Ribosome biogenesis in eukaryotes ko03013 RNA transport Uncharacterized conserved protein S Function unknown ; IPR002775 [DNA/RNA-binding protein Alba-like] -- -- Q3U413 Uncharacterized protein Spacdr 315.8 338.1 290.1 277.4 286.1 279.6 1.11967738109358 0.0757127525413968 0.163083100367736 Nonsignificant None -- -- -- -- -- Transcriptional regulator K Transcription ; IPR000580 [TSC-22 / Dip / Bun] -- TSC22 Q05DM9 Ubiquitinyl hydrolase 1 (Fragment) Vcpip1 319.4 306.9 319.5 287.8 350.5 322.5 0.984388009991674 0.801475962958814 -0.0227010092478296 Nonsignificant None -- -- deubiquitinating protein VCIP135 3.4.19.12 -- NF-kappa B regulator AP20/Cezanne T Signal transduction mechanisms ; IPR003323 [OTU domain] -- -- Q9CR59 Growth arrest and DNA damage-inducible proteins-interacting protein 1 Gadd45gip1 695.1 703.5 675.6 1079.9 1071.1 872.8 0.685958066009657 0.0409447571724769 -0.543807710630756 Nonsignificant None 2 Cellular Component:nucleus (GO:0005634),Biological Process:cell cycle (GO:0007049) -- -- -- Extracellular matrix-associated peroxidase WV Extracellular structures ; Defense mechanisms ; IPR018472 [Growth arrest/ DNA-damage-inducible protein-interacting protein 1] -- -- Q8R2Z5 von Willebrand factor A domain-containing protein 1 Vwa1 50.7 51.5 42.6 35 36.6 44.9 1.24291845493562 0.087133893146111 0.313731647541563 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Collagens (type IV and type XIII), and related proteins W Extracellular structures ; IPR002035 [von Willebrand factor, type A] ; IPR003961[Fibronectin type III] -- -- Q5EAT0 Signal recognition particle 9 kDa protein Srp9 711.9 785.5 648.1 712.3 672.7 676.6 1.04069654637175 0.538701176917299 0.057549458776128 Nonsignificant None -- -- signal recognition particle subunit SRP9 -- ko03060 Protein export Signal recognition particle, subunit Srp9 U Intracellular trafficking, secretion, and vesicular transport ; -- -- -- P55284 Cadherin-5 Cdh5 102.9 111.6 113.2 127 123.1 117 0.892672296377009 0.0385400424509925 -0.163797441556787 Nonsignificant None 3 Molecular Function:calcium ion binding (GO:0005509),Biological Process:homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156),Cellular Component:membrane (GO:0016020) cadherin 5, type 2, VE-cadherin -- ko04514 Cell adhesion molecules (CAMs) ko04670 Leukocyte transendothelial migration ko05418 Fluid shear stress and atherosclerosis FOG: Cadherin repeats S Function unknown ; IPR000233 [Cadherin, cytoplasmic domain] ; IPR002126[Cadherin] -- -- Q8VCH6 Delta(24)-sterol reductase Dhcr24 167.7 169.3 211.6 213.1 227.6 231.2 0.816490549188867 0.0558921132856486 -0.292491908080506 Nonsignificant None 3 Molecular Function:oxidoreductase activity (GO:0016491),Molecular Function:flavin adenine dinucleotide binding (GO:0050660),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00100 Steroid biosynthesis ko01100 Metabolic pathways FAD-binding protein DIMINUTO R General function prediction only ; IPR006094 [FAD linked oxidase, N-terminal] -- -- Q3U263 ZIP4_domain domain-containing protein Slc39a4 213.9 195.6 189.6 209 218.6 222.4 0.921692307692308 0.111195360353721 -0.11764288463805 Nonsignificant None 4 Cellular Component:membrane (GO:0016020),Biological Process:metal ion transport (GO:0030001),Molecular Function:metal ion transmembrane transporter activity (GO:0046873),Biological Process:transmembrane transport (GO:0055085) solute carrier family 39 (zinc transporter), member 4 -- ko04978 Mineral absorption Putative zinc transporter P Inorganic ion transport and metabolism ; IPR003689 [Zinc/iron permease] -- -- Q8K1J6 CCA tRNA nucleotidyltransferase 1, mitochondrial Trnt1 773.3 797.1 892.4 799.9 844.6 840.7 0.990986640914212 0.857836707315608 -0.0130624857265805 Nonsignificant None 3 Molecular Function:RNA binding (GO:0003723),Biological Process:RNA processing (GO:0006396),Molecular Function:nucleotidyltransferase activity (GO:0016779) -- -- ko03013 RNA transport tRNA nucleotidyltransferase/poly(A) polymerase J Translation, ribosomal structure and biogenesis ; IPR002646 [Poly A polymerase, head domain] ; IPR032828[tRNA nucleotidyltransferase/poly(A) polymerase, RNA and SrmB- binding domain] -- -- Q9QZK2 Breast cancer anti-estrogen resistance protein 3 homolog Bcar3 475.7 431.9 414.3 387.7 433.5 445.8 1.04333070244672 0.511258678067876 0.0611965185084477 Nonsignificant None 2 Molecular Function:guanyl-nucleotide exchange factor activity (GO:0005085),Biological Process:small GTPase mediated signal transduction (GO:0007264) -- -- -- -- -- -- IPR000980 [SH2 domain] ; IPR001895[Ras guanine-nucleotide exchange factors catalytic domain] -- -- P62315 Small nuclear ribonucleoprotein Sm D1 Snrpd1 1279.5 1014.6 799 745.1 805.2 816.7 1.30675961132235 0.221467192111875 0.385993770475227 Nonsignificant None -- -- small nuclear ribonucleoprotein D1 -- ko03040 Spliceosome ko05322 Systemic lupus erythematosus Small nuclear ribonucleoprotein SMD1 and related snRNPs A RNA processing and modification ; IPR001163 [LSM domain, eukaryotic/archaea-type] -- -- Q9D338 39S ribosomal protein L19, mitochondrial Mrpl19 487.7 430.6 475.9 460.8 467.7 469.7 0.997139178944357 0.946259801151201 -0.00413320735615197 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L19 -- ko03010 Ribosome Mitochondrial/chloroplast ribosomal protein L19 J Translation, ribosomal structure and biogenesis ; IPR001857 [Ribosomal protein L19] -- -- G3X9Q6 La-related protein 4 Larp4 1065.3 1065.5 1017.7 877.4 947.1 923.1 1.14590915708254 0.0066985832106999 0.196492677758634 Nonsignificant None -- -- la-related protein 4 -- -- c-Mpl binding protein, contains La domain T Signal transduction mechanisms ; IPR006630 [RNA-binding protein Lupus La] -- -- Q62313 Trans-Golgi network integral membrane protein 1 Tgoln1 807.4 715.2 880.3 985.3 1060 1195.5 0.74145272772155 0.0230455543487178 -0.431573380165269 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- I7DM66 PexRAP Dhrs7b 771.9 710.7 821.2 733.3 731.2 705.7 1.06156114643812 0.250518823911067 0.0861874735724073 Nonsignificant None -- -- dehydrogenase/reductase SDR family member 7B 1.1.-.- -- Predicted dehydrogenase Q Secondary metabolites biosynthesis, transport and catabolism ; IPR002347 [Short-chain dehydrogenase/reductase SDR] -- -- A0A1G5SJ81 Irgb6 homologue OTTMUSPWKG00059381 1304.9 1722.1 1023.5 691.8 757.2 693.7 1.89037196061044 0.0869134845409719 0.918670135467421 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Cellular Component:membrane (GO:0016020) -- -- -- -- -- -- IPR007743 [Immunity-related GTPases-like] -- -- Q3ULN2 Transcription initiation factor IIB Gtf2b 128 124.4 123.1 136.8 131 124.4 0.957419683834778 0.223731280904209 -0.062776627790515 Nonsignificant None 1 Molecular Function:TBP-class protein binding (GO:0017025) transcription initiation factor TFIIB -- ko03022 Basal transcription factors ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis Transcription initiation factor TFIIB K Transcription ; IPR013137 [Zinc finger, TFIIB-type] ; IPR013150[Transcription factor TFIIB, cyclin-like domain] -- -- Q9Z0F4 Calcium and integrin-binding protein 1 Cib1 528.9 506.3 554.5 489.5 522.2 475.7 1.06877773295684 0.156793789981198 0.0959618559566134 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) calcium and integrin-binding protein 1 -- -- Ca2+/calmodulin-dependent protein phosphatase (calcineurin subunit B), EF-Hand superfamily protein T Signal transduction mechanisms ; IPR002048 [EF-hand domain] -- -- Q3TZX8 Polynucleotide 5-hydroxyl-kinase NOL9 Nol9 511.4 558.6 483.6 481.8 469 464.9 1.09740764286219 0.110280969066572 0.134099528561193 Nonsignificant None -- -- polynucleotide 5'-hydroxyl-kinase GRC3/NOL9 2.7.1.- -- Uncharacterized conserved protein similar to ATP/GTP-binding protein R General function prediction only ; IPR032319 [Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain] -- -- Q3TSG4 RNA demethylase ALKBH5 Alkbh5 316.6 312.5 190.7 222.7 232.8 233.9 1.18914998549463 0.403028719133794 0.249930691267509 Nonsignificant None -- -- mRNA N6-methyladenine demethylase 1.14.11.53 -- Uncharacterized conserved protein S Function unknown ; IPR027450 [Alpha-ketoglutarate-dependent dioxygenase AlkB-like] -- -- Q4FJX5 Dhcr7 protein Dhcr7 633.5 530.4 556.7 703 746.5 685.6 0.805863893962812 0.0182261498904558 -0.311391898920695 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) 7-dehydrocholesterol reductase 1.3.1.21 ko00100 Steroid biosynthesis ko01100 Metabolic pathways Sterol reductase/lamin B receptor IT Lipid transport and metabolism ; Signal transduction mechanisms ; IPR001171 [Ergosterol biosynthesis ERG4/ERG24] -- -- A0PK78 Coiled-coil domain-containing protein 25 Ccdc25 1564.1 1577.2 1340 1134.9 1199.9 1243.5 1.25235446999972 0.0223941496386343 0.324642964611559 Nonsignificant None -- -- -- -- -- Predicted coiled-coil protein R General function prediction only ; IPR008532 [Domain of unknown function DUF814] -- -- A0A0R4J0Q4 Lysyl oxidase homolog Loxl1 345.5 298.6 273.4 284.1 281.7 268.8 1.09932901988977 0.270951739275749 0.136623237354542 Nonsignificant None 2 Molecular Function:copper ion binding (GO:0005507),Biological Process:oxidation-reduction process (GO:0055114) lysyl oxidase-like protein 1 1.4.3.- -- -- -- -- IPR001695 [Lysyl oxidase] -- -- A6PWD6 Predicted gene 5431 Gm5431 33.2 42 44 43.6 57.8 49.4 0.790450928381963 0.117347226778795 -0.339252192806503 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Cellular Component:membrane (GO:0016020) interferon gamma inducible protein 47 -- ko04668 TNF signaling pathway -- -- -- IPR007743 [Immunity-related GTPases-like] -- -- Q64471 Glutathione S-transferase theta-1 Gstt1 1026.7 1025.7 1092.7 1247.6 1344.3 1317.1 0.804579176259913 0.00218332313170371 -0.31369369559561 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) glutathione S-transferase 2.5.1.18 ko00480 Glutathione metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko01524 Platinum drug resistance ko05200 Pathways in cancer ko05204 Chemical carcinogenesis ko05225 Hepatocellular carcinoma ko05418 Fluid shear stress and atherosclerosis Glutathione S-transferase O Posttranslational modification, protein turnover, chaperones ; IPR004045 [Glutathione S-transferase, N-terminal] ; IPR004046[Glutathione S-transferase, C-terminal] -- -- Q8BHJ5 F-box-like/WD repeat-containing protein TBL1XR1 Tbl1xr1 471.3 466.6 492.1 491.7 479.9 475.8 0.987978444106674 0.561442982394394 -0.0174485297167393 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) transducin (beta)-like 1 -- ko04310 Wnt signaling pathway Beta-transducin family (WD-40 repeat) protein B Chromatin structure and dynamics ; IPR001680 [WD40 repeat] ; IPR006594[LIS1 homology motif] -- -- Q6P5G6 UBX domain-containing protein 7 Ubxn7 306.7 291.6 303.3 289.6 299.7 322.8 0.98848810437452 0.762918788846398 -0.0167044904535174 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Predicted ubiquitin regulatory protein, contains UAS and UBX domains O Posttranslational modification, protein turnover, chaperones ; IPR001012 [UBX domain] -- -- Q61789 Laminin subunit alpha-3 Lama3 649.4 653.8 581.7 533.6 569.3 581.9 1.11876780626781 0.0720198154466055 0.161910644441544 Nonsignificant None 5 Molecular Function:receptor binding (GO:0005102),Biological Process:cell adhesion (GO:0007155),Biological Process:regulation of cell adhesion (GO:0030155),Biological Process:regulation of cell migration (GO:0030334),Biological Process:regulation of embryonic development (GO:0045995) laminin, alpha 3/5 -- ko01100 Metabolic pathways ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko05145 Toxoplasmosis ko05146 Amoebiasis ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05222 Small cell lung cancer Extracellular matrix glycoprotein Laminin subunits alpha and gamma W Extracellular structures ; IPR000034 [Laminin IV] ; IPR001791[Laminin G domain] ; IPR002049[Laminin EGF domain] ; IPR008211[Laminin, N-terminal] ; IPR009254[Laminin alpha, domain I] ; IPR010307[Laminin domain II] -- -- V9GXJ1 Predicted gene, 28036 Gm28036 810.4 761.5 850.6 760.4 751.5 793.6 1.05074821080026 0.246733976957679 0.0714169998905158 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- RNA binding protein RBM12/SWAN R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- G5E897 Protein O-glucosyltransferase 3 Poglut3 904.7 941.9 717.7 734.3 741.9 683.2 1.18750578864499 0.133222924009875 0.247934546057541 Nonsignificant None -- -- -- -- -- Endoplasmic reticulum protein EP58, contains filamin rod domain and KDEL motif R General function prediction only ; IPR006598 [Lipopolysaccharide-modifying protein] ; IPR017868[Filamin/ABP280 repeat-like] -- -- Q9D816 Cytochrome P450 2C55 Cyp2c55 238.7 219.4 330 608.8 343.9 429.7 0.570095486111111 0.0805947212201128 -0.81072451630868 Nonsignificant None 3 Molecular Function:iron ion binding (GO:0005506),Molecular Function:heme binding (GO:0020037),Biological Process:oxidation-reduction process (GO:0055114) cytochrome P450 family 2 subfamily C 1.14.14.1 ko00140 Steroid hormone biosynthesis ko00590 Arachidonic acid metabolism ko00591 Linoleic acid metabolism ko00830 Retinol metabolism ko01100 Metabolic pathways ko04726 Serotonergic synapse ko04750 Inflammatory mediator regulation of TRP channels ko05204 Chemical carcinogenesis Cytochrome P450 CYP2 subfamily Q Secondary metabolites biosynthesis, transport and catabolism ; IPR001128 [Cytochrome P450] -- -- Q8BM55 Transmembrane protein 214 Tmem214 1420 1328 1352.3 1187.8 1148.7 1253 1.14230394205321 0.014257600125406 0.191946571323051 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019308 [Transmembrane protein 214] -- -- Q9D7A8 Armadillo repeat-containing protein 1 Armc1 585.8 560.1 630 586.8 541.7 591.8 1.03231994419578 0.513715175761491 0.0458901707309264 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) armadillo repeat-containing protein 1 -- -- -- -- -- IPR000225 [Armadillo] -- -- Q99LU0 Charged multivesicular body protein 1b-1 Chmp1b1 696.1 767.8 1182.8 1029.8 997.5 926.8 0.895941234216851 0.544008902172604 -0.15852398747536 Nonsignificant None 1 Biological Process:vacuolar transport (GO:0007034) charged multivesicular body protein 1 -- ko04144 Endocytosis ko04217 Necroptosis Vacuolar assembly/sorting protein DID2 U Intracellular trafficking, secretion, and vesicular transport ; IPR005024 [Snf7 family] -- -- Q9CPT0 Apoptosis facilitator Bcl-2-like protein 14 Bcl2l14 1389.5 1389.1 1686.4 1863.3 1869.3 1791.7 0.808247198740112 0.0258738981491728 -0.307131492685401 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- E9Q4Z2 Acetyl-CoA carboxylase 2 Acacb 198 171.8 213.8 160.6 164.5 176.1 1.16440542697526 0.10408579998053 0.21959346859603 Nonsignificant None 3 Molecular Function:acetyl-CoA carboxylase activity (GO:0003989),Molecular Function:ATP binding (GO:0005524),Biological Process:fatty acid biosynthetic process (GO:0006633) -- -- ko00061 Fatty acid biosynthesis ko00620 Pyruvate metabolism ko00640 Propanoate metabolism ko01100 Metabolic pathways ko04152 AMPK signaling pathway ko04910 Insulin signaling pathway ko04920 Adipocytokine signaling pathway ko04922 Glucagon signaling pathway ko04931 Insulin resistance Acetyl-CoA carboxylase I Lipid transport and metabolism ; IPR000022 [Carboxyl transferase] ; IPR000089[Biotin/lipoyl attachment] ; IPR005479[Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain] ; IPR005481[Biotin carboxylase-like, N-terminal domain] ; IPR005482[Biotin carboxylase, C-terminal] ; IPR013537[Acetyl-CoA carboxylase, central domain] -- -- B9EJ37 SH3 and PX domains 2B Sh3pxd2b 634.1 687.7 729.2 632.4 640.7 614.9 1.08633474576271 0.12985408876128 0.119468727118011 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:phosphatidylinositol binding (GO:0035091) -- -- -- -- -- -- IPR001452 [SH3 domain] ; IPR001683[Phox homologous domain] ; IPR011511[Variant SH3 domain] -- -- Q8VHK9 ATP-dependent DNA/RNA helicase DHX36 Dhx36 226.9 189.8 209.6 227.1 227.4 226.7 0.919406928948914 0.229834083602863 -0.121224556073772 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:helicase activity (GO:0004386),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase DHX36 3.6.4.13 ko03018 RNA degradation ATP-dependent RNA helicase A A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR007502[Helicase-associated domain] ; IPR011545[DEAD/DEAH box helicase domain] ; IPR011709[Domain of unknown function DUF1605] -- -- Q2YDW2 Protein misato homolog 1 Msto1 312.5 266.4 259.4 260.9 237.9 251.9 1.11669108831757 0.179125593636516 0.159230146439743 Nonsignificant None -- -- -- -- -- Members of tubulin/FtsZ family Z Cytoskeleton ; IPR019605 [Misato Segment II tubulin-like domain] ; IPR029209[DML1/Misato, tubulin domain] -- -- Q922M3 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 Kctd10 425.1 462.2 343.4 317.7 318.5 340.3 1.26031746031746 0.0774375353291103 0.333787178755679 Nonsignificant None 1 Biological Process:protein homooligomerization (GO:0051260) BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein -- -- Polymerase delta-interacting protein PDIP1 and related proteins, contain BTB/POZ domain P Inorganic ion transport and metabolism ; IPR003131 [Potassium channel tetramerisation-type BTB domain] -- ZBTB Q3U1V6 Ubiquitin-conjugating enzyme E2 variant 3 Uevld 379.7 364.7 336.8 454.1 453.2 434.3 0.805903398926655 0.00356102168936587 -0.311321177029652 Nonsignificant None 4 Biological Process:cellular protein modification process (GO:0006464),Biological Process:protein transport (GO:0015031),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) -- -- -- Lactate dehydrogenase C Energy production and conversion ; IPR001236 [Lactate/malate dehydrogenase, N-terminal] ; IPR008883[Ubiquitin E2 variant, N-terminal] ; IPR022383[Lactate/malate dehydrogenase, C-terminal] -- -- Q5SVR0 TBC1 domain family member 9B Tbc1d9b 83.6 80.3 80.8 106 115.7 103.6 0.752228711958192 0.00219340720304896 -0.410756720961742 Nonsignificant None -- -- TBC1 domain family member 8/9 -- -- GTPase-activating protein VRP R General function prediction only ; IPR000195 [Rab-GTPase-TBC domain] ; IPR004182[GRAM domain] -- -- A0A0G2JGL8 RNA helicase Dhx30 366 504.5 521.8 467.3 455 441.2 1.02112211221122 0.864436011029699 0.0301554030887223 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:helicase activity (GO:0004386),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase DHX30 3.6.4.13 -- ATP-dependent RNA helicase A A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR007502[Helicase-associated domain] ; IPR011545[DEAD/DEAH box helicase domain] ; IPR011709[Domain of unknown function DUF1605] -- -- Q3TYE9 Uncharacterized protein (Fragment) Reep2 20.3 19.3 29.4 23.4 30.2 27.6 0.849753694581281 0.341954672726784 -0.234883365519645 Nonsignificant None -- -- receptor expression-enhancing protein 1/2/3/4 -- -- HVA22/DP1 gene product-related proteins V Defense mechanisms ; -- -- -- D3Z5U5 P2X purinoceptor P2rx4 996.4 964.5 1336.4 1518.9 1615.4 1582.2 0.699098908088625 0.0180357521887725 -0.516431513228937 Nonsignificant None 5 Molecular Function:purinergic nucleotide receptor activity (GO:0001614),Molecular Function:extracellular ATP-gated cation channel activity (GO:0004931),Cellular Component:integral component of plasma membrane (GO:0005887),Biological Process:response to ATP (GO:0033198),Biological Process:cation transmembrane transport (GO:0098655) P2X purinoceptor 4 -- ko04020 Calcium signaling pathway ko04080 Neuroactive ligand-receptor interaction -- -- -- IPR001429 [P2X purinoreceptor] -- -- Q8K124 Pleckstrin homology domain-containing family O member 2 Plekho2 452.3 481.8 417.1 435.5 458.7 436.2 1.01563439567048 0.74863193814543 0.0223811595141169 Nonsignificant None -- -- -- -- -- -- -- -- IPR001849 [Pleckstrin homology domain] -- -- Q8K3C3 Protein LZIC Lzic 478.5 412 393.2 442.3 440.7 456.8 0.958128078817734 0.517494745709986 -0.0617095721989845 Nonsignificant None 1 Molecular Function:beta-catenin binding (GO:0008013) -- -- -- -- -- -- IPR009428 [Beta-catenin-interacting ICAT] -- -- Q8BWR2 PITH domain-containing protein 1 Pithd1 487.5 483.3 498.4 540.8 539.5 556 0.897879361975188 0.00131486435449562 -0.155406475724706 Nonsignificant None -- -- -- -- -- Thioredoxin-like protein O Posttranslational modification, protein turnover, chaperones ; IPR010400 [PITH domain] -- -- Q9CY97 RNA polymerase II subunit A C-terminal domain phosphatase SSU72 Ssu72 497 469.2 448.7 417 377.9 422.1 1.16261298274445 0.0289185316647822 0.217370924155911 Nonsignificant None 3 Molecular Function:phosphoprotein phosphatase activity (GO:0004721),Cellular Component:nucleus (GO:0005634),Biological Process:mRNA processing (GO:0006397) RNA polymerase II subunit A C-terminal domain phosphatase SSU72 3.1.3.16 ko03015 mRNA surveillance pathway Protein involved in transcription start site selection K Transcription ; IPR006811 [RNA polymerase II subunit A] -- -- Q923U0 TOM1-like protein 1 Tom1l1 458.4 445.6 513.5 480.3 474.2 504 0.971888926979774 0.580029080186025 -0.0411366510685865 Nonsignificant None 2 Cellular Component:intracellular (GO:0005622),Biological Process:intracellular protein transport (GO:0006886) -- -- -- Cytosolic sorting protein GGA2/TOM1 U Intracellular trafficking, secretion, and vesicular transport ; IPR002014 [VHS domain] ; IPR004152[GAT domain] -- -- Q91VV4 DENN domain-containing protein 2D Dennd2d 148.4 170.3 201.9 189.7 168 168.2 0.989922038410344 0.922761062256822 -0.014613185076582 Nonsignificant None -- -- DENN domain-containing protein 2 -- -- RAS signaling inhibitor ST5 T Signal transduction mechanisms ; IPR001194 [DENN domain] ; IPR005112[dDENN domain] ; IPR005113[uDENN domain] -- -- Q91WN1 DnaJ homolog subfamily C member 9 Dnajc9 718.4 725.8 760.5 659 659.8 650.2 1.11970543423057 0.00415166125152159 0.163119246149817 Nonsignificant None -- -- DnaJ homolog subfamily C member 9 -- -- Molecular chaperone (DnaJ superfamily) O Posttranslational modification, protein turnover, chaperones ; IPR001623 [DnaJ domain] -- -- A0A2R8W6P0 Leukocyte surface antigen CD47 Cd47 208.2 214.9 277.2 246.9 262.9 229.4 0.947375541125541 0.617742487200149 -0.0779916692762586 Nonsignificant None -- -- CD47 antigen (Rh-related antigen, integrin-associated signal transducer) -- ko04512 ECM-receptor interaction -- -- -- IPR013147 [CD47 transmembrane] ; IPR013270[CD47 immunoglobulin-like] -- -- Q9D937 Uncharacterized protein C11orf98 homolog 454.3 478.2 490.7 470.6 449.3 452.1 1.03731778425656 0.246932574004091 0.0528579342069851 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- P52800 Ephrin-B2 Efnb2 149.2 147.2 131.1 163 157.1 181.3 0.852612684483446 0.0565162864779994 -0.230037576173317 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) ephrin-B -- ko04360 Axon guidance Ephrin, ligand for Eph receptor tyrosine kinase T Signal transduction mechanisms ; IPR001799 [Ephrin receptor-binding domain] -- -- O88895 Histone deacetylase 3 Hdac3 153.1 139.2 125.8 130.9 145.9 131.3 1.0245037980887 0.738107750837266 0.0349253327860369 Nonsignificant None -- -- histone deacetylase 3 3.5.1.98 ko04919 Thyroid hormone signaling pathway ko05034 Alcoholism ko05165 Human papillomavirus infection ko05203 Viral carcinogenesis Histone deacetylase complex, catalytic component RPD3 B Chromatin structure and dynamics ; IPR023801 [Histone deacetylase domain] -- -- Q99JI1 Musculoskeletal embryonic nuclear protein 1 Mustn1 1111.3 1194.2 849.5 1016.4 1136.4 1237.3 0.930651013244447 0.555397063571252 -0.103687824901955 Nonsignificant None 4 Biological Process:chondrocyte differentiation (GO:0002062),Cellular Component:nucleus (GO:0005634),Biological Process:chondrocyte proliferation (GO:0035988),Biological Process:tissue regeneration (GO:0042246) -- -- -- -- -- -- IPR031394 [Musculoskeletal embryonic nuclear protein 1] -- -- Q6NVF2 Phospholipase Pld1 473.1 430.3 488.2 469.5 453.6 466.9 1.00115107913669 0.977813610421648 0.00165970112165816 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Molecular Function:phosphatidylinositol binding (GO:0035091) phospholipase D1/2 3.1.4.4 ko00564 Glycerophospholipid metabolism ko00565 Ether lipid metabolism ko01100 Metabolic pathways ko04014 Ras signaling pathway ko04024 cAMP signaling pathway ko04071 Sphingolipid signaling pathway ko04072 Phospholipase D signaling pathway ko04144 Endocytosis ko04666 Fc gamma R-mediated phagocytosis ko04724 Glutamatergic synapse ko04912 GnRH signaling pathway ko05231 Choline metabolism in cancer Phospholipase D1 I Lipid transport and metabolism ; IPR001683 [Phox homologous domain] ; IPR001736[Phospholipase D/Transphosphatidylase] ; IPR001849[Pleckstrin homology domain] ; IPR025202[Phospholipase D-like domain] -- -- E3VRZ6 Calcium-activated potassium channel subunit alpha-1 Kcnma1 88.2 80.4 92.6 72.7 91.8 99 0.991271347248577 0.933401904533711 -0.0126480649781461 Nonsignificant None 5 Molecular Function:ion channel activity (GO:0005216),Biological Process:ion transport (GO:0006811),Biological Process:potassium ion transport (GO:0006813),Cellular Component:membrane (GO:0016020),Biological Process:transmembrane transport (GO:0055085) potassium large conductance calcium-activated channel subfamily M alpha member 1 -- ko04022 cGMP-PKG signaling pathway ko04270 Vascular smooth muscle contraction ko04911 Insulin secretion ko04924 Renin secretion ko04970 Salivary secretion ko04972 Pancreatic secretion Ca2+-activated K+ channel Slowpoke, alpha subunit PT Inorganic ion transport and metabolism ; Signal transduction mechanisms ; IPR003929 [Potassium channel, BK, alpha subunit] ; IPR005821[Ion transport domain] -- -- Q8K2Q0 COMM domain-containing protein 9 Commd9 160.8 152.3 148.4 140.8 141.5 169 1.022601373809 0.750510723175635 0.0322438693206493 Nonsignificant None -- -- -- -- -- IPR017920 [COMM domain] -- -- F8VQ52 Adenylate cyclase type 6 Adcy6 146.3 153.1 144.8 146.1 148.7 162.4 0.97156605424322 0.48690033960995 -0.0416160106674977 Nonsignificant None 6 Molecular Function:adenylate cyclase activity (GO:0004016),Cellular Component:plasma membrane (GO:0005886),Biological Process:cAMP biosynthetic process (GO:0006171),Biological Process:cyclic nucleotide biosynthetic process (GO:0009190),Molecular Function:phosphorus-oxygen lyase activity (GO:0016849),Biological Process:intracellular signal transduction (GO:0035556) adenylate cyclase 6 4.6.1.1 ko00230 Purine metabolism ko01522 Endocrine resistance ko04015 Rap1 signaling pathway ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04062 Chemokine signaling pathway ko04072 Phospholipase D signaling pathway ko04114 Oocyte meiosis ko04211 Longevity regulating pathway ko04213 Longevity regulating pathway - multiple species ko04261 Adrenergic signaling in cardiomyocytes ko04270 Vascular smooth muscle contraction ko04371 Apelin signaling pathway ko04540 Gap junction ko04611 Platelet activation ko04713 Circadian entrainment ko04723 Retrograde endocannabinoid signaling ko04724 Glutamatergic synapse ko04725 Cholinergic synapse ko04727 GABAergic synapse ko04742 Taste transduction ko04750 Inflammatory mediator regulation of TRP channels ko04911 Insulin secretion ko04912 GnRH signaling pathway ko04913 Ovarian steroidogenesis ko04914 Progesterone-mediated oocyte maturation ko04915 Estrogen signaling pathway ko04916 Melanogenesis ko04918 Thyroid hormone synthesis ko04921 Oxytocin signaling pathway ko04923 Regulation of lipolysis in adipocytes ko04924 Renin secretion ko04925 Aldosterone synthesis and secretion ko04926 Relaxin signaling pathway ko04961 Endocrine and other factor-regulated calcium reabsorption ko04962 Vasopressin-regulated water reabsorption ko04970 Salivary secretion ko04971 Gastric acid secretion ko04972 Pancreatic secretion ko04976 Bile secretion ko05032 Morphine addiction ko05166 HTLV-I infection ko05200 Pathways in cancer ko05414 Dilated cardiomyopathy (DCM) Adenylate/guanylate cyclase C Energy production and conversion ; IPR001054 [Adenylyl cyclase class-3/4/guanylyl cyclase] ; IPR009398[Adenylate cyclase, conserved domain] ; IPR032628[Adenylate cyclase, N-terminal] -- -- O35218 Cleavage and polyadenylation specificity factor subunit 2 Cpsf2 375.5 366.2 477.2 480.9 511.5 473 0.831786542923434 0.0932092573895715 -0.265714750387193 Nonsignificant None -- -- cleavage and polyadenylation specificity factor subunit 2 -- ko03015 mRNA surveillance pathway mRNA cleavage and polyadenylation factor II complex, subunit CFT2 (CPSF subunit) A RNA processing and modification ; IPR001279 [Metallo-beta-lactamase] ; IPR011108[Zn-dependent metallo-hydrolase, RNA specificity domain] ; IPR022712[Beta-Casp domain] ; IPR025069[Cleavage and polyadenylation specificity factor 2, C-terminal] -- -- D6RI20 Immediate early response 3-interacting protein 1 Gm50364 531.6 514.4 504.4 541.8 557.7 521.6 0.956387638023564 0.146945165969721 -0.0643326125556812 Nonsignificant None -- -- -- -- -- Predicted membrane protein S Function unknown ; IPR013880 [Yos1-like] -- -- Q8C027 Vacuolar protein sorting-associated protein 11 homolog Vps11 511.8 509.8 417.4 431.7 466.8 453.8 1.06411299267914 0.427777832716279 0.0896513513303969 Nonsignificant None 2 Biological Process:intracellular protein transport (GO:0006886),Biological Process:vesicle-mediated transport (GO:0016192) vacuolar protein sorting-associated protein 11 -- Vacuolar assembly/sorting protein PEP5/VPS11 U Intracellular trafficking, secretion, and vesicular transport ; IPR000547 [Clathrin, heavy chain/VPS, 7-fold repeat] -- -- Q3TMQ3 Claudin (Fragment) Cldn3 862.1 754.6 774.8 964.7 968.2 925.4 0.836686142112444 0.0121058918856315 -0.257241554710009 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) claudin -- ko04514 Cell adhesion molecules (CAMs) ko04530 Tight junction ko04670 Leukocyte transendothelial migration ko05160 Hepatitis C -- -- -- IPR004031 [PMP-22/EMP/MP20/Claudin superfamily] -- -- O35609 Secretory carrier-associated membrane protein 3 Scamp3 610.1 653.2 509.7 560.5 616.2 545.5 1.029497154802 0.740220209118899 0.0419398428320215 Nonsignificant None 2 Biological Process:protein transport (GO:0015031),Cellular Component:integral component of membrane (GO:0016021) secretory carrier-associated membrane protein -- -- Secretory carrier membrane protein U Intracellular trafficking, secretion, and vesicular transport ; IPR007273 [SCAMP] -- -- A0A5F8MPS7 Lysosomal acid phosphatase Acp2 642.7 606.5 631.4 716.8 729.6 682 0.883574516068408 0.00971786966059644 -0.178576285601053 Nonsignificant None 1 Molecular Function:acid phosphatase activity (GO:0003993) lysosomal acid phosphatase 3.1.3.2 ko00740 Riboflavin metabolism ko01100 Metabolic pathways ko04142 Lysosome Lysosomal & prostatic acid phosphatases I Lipid transport and metabolism ; IPR000560 [Histidine phosphatase superfamily, clade-2] -- -- A0A140LHT6 39S ribosomal protein L48, mitochondrial Mrpl48 969.3 1024.1 1190.5 1208.5 1167.1 1190.7 0.892774023497743 0.132339954877728 -0.163633044328899 Nonsignificant None -- -- large subunit ribosomal protein L48 -- -- Uncharacterized conserved protein S Function unknown ; IPR027486 [Ribosomal protein S10 domain] -- -- Q9DCL8 Protein phosphatase inhibitor 2 Ppp1r2 711.7 774.5 614.3 649 593 689.9 1.08727159790879 0.360028250904559 0.12071236723972 Nonsignificant None 3 Molecular Function:protein phosphatase inhibitor activity (GO:0004864),Biological Process:regulation of signal transduction (GO:0009966),Biological Process:regulation of phosphoprotein phosphatase activity (GO:0043666) protein phosphatase inhibitor 2 -- -- Protein phosphatase 1, regulatory (inhibitor) subunit PPP1R2 OT Posttranslational modification, protein turnover, chaperones ; Signal transduction mechanisms ; IPR007062 [Protein phosphatase inhibitor 2 (IPP-2)] -- -- G3UZ04 Myotubularin-related protein 12 Mtmr12 156.6 183.4 251.9 226.5 223.2 228.5 0.872751400766736 0.417406745900473 -0.196357327580716 Nonsignificant None -- -- myotubularin-related protein 10/11/12 -- -- Myotubularin-related phosphatidylinositol 3-phosphate 3-phosphatase MTM6 R General function prediction only ; IPR010569 [Myotubularin-like phosphatase domain] -- -- Q2KHK7 Mal, T-cell differentiation protein 2 Mal2 666.8 622.9 736.3 616.3 550.2 568.2 1.16792528967545 0.0650262608910462 0.223947990260693 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) -- -- -- Members of chemokine-like factor super family and related proteins V Defense mechanisms ; IPR008253 [Marvel domain] -- -- A2AMU9 Ribosome assembly factor mrt4 Mrto4 840.5 841.2 793.2 610 644 686.7 1.27526150358118 0.00284859084218015 0.35079311472009 Nonsignificant None 2 Cellular Component:intracellular (GO:0005622),Biological Process:ribosome biogenesis (GO:0042254) mRNA turnover protein 4 -- -- Protein involved in mRNA turnover A RNA processing and modification ; IPR001790 [Ribosomal protein L10P] -- -- Q6NTA4 Ras-related GTP-binding protein B Rragb 470.3 463.1 384.4 479.5 461.1 457.1 0.942834656936395 0.40089264034706 -0.0849233044035307 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) Ras-related GTP-binding protein A/B -- ko04140 Autophagy - animal ko04150 mTOR signaling pathway GTP-binding protein T Signal transduction mechanisms ; IPR006762 [Gtr1/RagA G protein] -- -- Q3UDR8 Protein YIPF3 Yipf3 160.6 200.8 131.3 157.1 224.5 165.2 0.901060716898318 0.571259712909394 -0.150303771293876 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; -- -- -- A2AP78 High mobility group protein B3 (Fragment) Hmgb3 945.3 945.9 1168 1135.5 1148.7 1162.9 0.887470627483972 0.222208885354517 -0.172228723308826 Nonsignificant None -- -- high mobility group protein B3 -- -- HMG box-containing protein R General function prediction only ; IPR009071 [High mobility group box domain] -- HMG D6RJK7 TATA element modulatory factor Tmf1 810.1 766.2 701.4 715 722 723.1 1.054441923985 0.340075747580178 0.0764796372974153 Nonsignificant None -- -- TATA element modulatory factor -- -- Transcription factor TMF, TATA element modulatory factor K Transcription ; IPR022092 [TATA element modulatory factor 1 DNA binding] -- -- Q921N6 Probable ATP-dependent RNA helicase DDX27 Ddx27 998.7 929.2 948.7 942.7 964 980.2 0.996432159063355 0.890320018432961 -0.00515651071073914 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase DDX27 3.6.4.13 -- ATP-dependent RNA helicase A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR011545[DEAD/DEAH box helicase domain] -- -- A0A0R4J124 SRSF protein kinase 2 Srpk2 126.3 124.9 123.6 88.5 99.9 109.7 1.25729620932573 0.0508187825297572 0.330324577668018 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) serine/threonine-protein kinase SRPK2 2.7.11.1 -- Serine/threonine protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- A2A8L5 Receptor-type tyrosine-protein phosphatase F Ptprf 193.4 184 234.6 232.6 241.8 228.4 0.87080250426864 0.132120010028116 -0.199582538428362 Nonsignificant None 3 Molecular Function:protein tyrosine phosphatase activity (GO:0004725),Molecular Function:protein binding (GO:0005515),Biological Process:protein dephosphorylation (GO:0006470) receptor-type tyrosine-protein phosphatase F 3.1.3.48 ko04514 Cell adhesion molecules (CAMs) ko04520 Adherens junction ko04910 Insulin signaling pathway ko04931 Insulin resistance Protein tyrosine phosphatase T Signal transduction mechanisms ; IPR000242 [PTP type protein phosphatase] ; IPR003961[Fibronectin type III] ; IPR013098[Immunoglobulin I-set] -- -- P20352 Tissue factor F3 140.9 160.8 137.1 179.5 217.9 156.8 0.791771923493324 0.116845181370547 -0.336843185078224 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) coagulation factor III (tissue factor) -- ko04610 Complement and coagulation cascades ko04933 AGE-RAGE signaling pathway in diabetic complications -- -- -- IPR003961 [Fibronectin type III] ; IPR015373[Interferon/interleukin receptor domain] -- -- Q5M8N4 Epimerase family protein SDR39U1 Sdr39u1 291.8 293.8 326.1 355 336.7 393.5 0.840121636564689 0.0450913531647476 -0.251329872038415 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Molecular Function:coenzyme binding (GO:0050662) uncharacterized protein -- -- Predicted nucleoside-diphosphate sugar epimerase F Nucleotide transport and metabolism ; IPR001509 [NAD-dependent epimerase/dehydratase] ; IPR013549[Domain of unknown function DUF1731] -- -- Q3UPW2 ETS-related transcription factor Elf-3 Elf3 554.9 532.5 462.1 399.7 414.6 390.1 1.28653271338426 0.0163059881165858 0.363488141748901 Nonsignificant None 2 Cellular Component:nucleus (GO:0005634),Molecular Function:sequence-specific DNA binding (GO:0043565) E74-like factor 3 -- -- Transcription factor NERF and related proteins, contain ETS domain K Transcription ; IPR000418 [Ets domain] ; IPR003118[Pointed domain] -- ETS Q8VC88 Grancalcin Gca 497.6 531.7 446.7 514.3 502.7 509.2 0.967107849561001 0.568976127930678 -0.0482513103033858 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) -- -- -- Ca2+-binding protein, EF-Hand protein superfamily T Signal transduction mechanisms ; IPR002048 [EF-hand domain] -- -- Q99PN3 Tripartite motif-containing protein 26 Trim26 240.2 219.2 231.9 245.3 237.7 249.1 0.944269908482448 0.122609682263993 -0.0827287988895145 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Cellular Component:intracellular (GO:0005622),Molecular Function:zinc ion binding (GO:0008270) tripartite motif-containing protein 26 -- -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR000315 [B-box-type zinc finger] ; IPR003877[SPRY domain] ; IPR006574[SPRY-associated] -- -- Q3TYS2 Cytochrome b-245 chaperone 1 Cybc1 370.7 369.1 472.9 494.4 538.2 505.5 0.788440283466615 0.0419652034770158 -0.342926605577474 Nonsignificant None -- -- -- -- -- -- -- -- IPR027846 [Protein of unknown function DUF4564] -- -- Q3U896 Myotubularin phosphatase domain-containing protein Mtmr9 989.3 901.3 888.8 847.7 937.9 930.5 1.02330547476161 0.648214506068867 0.033236879333231 Nonsignificant None -- -- myotubularin-related protein 9 -- -- Myotubularin-related phosphatidylinositol 3-phosphate 3-phosphatase MTM6 R General function prediction only ; IPR010569 [Myotubularin-like phosphatase domain] -- -- Q8K3K8 Optineurin Optn 552.7 543.1 545.9 508.2 535.6 488.2 1.07160574412533 0.0596646639623537 0.0997742195879205 Nonsignificant None -- -- optineurin -- ko04137 Mitophagy - animal -- -- -- IPR021063 [NF-kappa-B essential modulator NEMO, N-terminal] ; IPR032419[NF-kappa-B essential modulator NEMO, CC2-LZ domain] -- -- Q8BH74 Nuclear pore complex protein Nup107 Nup107 583.3 552.8 498.1 521.2 552.2 513.3 1.02993634587509 0.596984978528865 0.0425551759248803 Nonsignificant None 2 Cellular Component:nuclear pore (GO:0005643),Biological Process:transport (GO:0006810) nuclear pore complex protein Nup107 -- ko03013 RNA transport Nuclear pore complex, rNup107 component (sc Nup84) YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; IPR007252 [Nuclear pore protein 84/107] -- -- A0A1L1ST22 CLIP-associating protein 2 Clasp2 125.7 134.9 170.9 191.5 218.2 171.3 0.742685025817556 0.0616856908615245 -0.429177604225574 Nonsignificant None -- -- CLIP-associating protein 1/2 -- -- CLIP-associating protein R General function prediction only ; IPR024395 [CLASP N-terminal domain] -- -- Q8C9S4 Coiled-coil domain-containing protein 186 Ccdc186 413.6 379.6 412.1 474.4 492.6 450.7 0.85017986880158 0.0125718016178046 -0.234159996724175 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; -- -- -- I7HLV5 Novel protein (Fragment) Fam3a 83.9 73.3 68.7 104.6 92 110.2 0.736310299869622 0.0183989509139836 -0.441614212109849 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q8R1G6 PDZ and LIM domain protein 2 Pdlim2 243.6 337.5 446.2 372.9 386.6 264.7 1.00302675258739 0.988943741966196 0.00436008582091707 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:zinc ion binding (GO:0008270) -- -- -- Adaptor protein Enigma and related PDZ-LIM proteins TZ Signal transduction mechanisms ; Cytoskeleton ; IPR001478 [PDZ domain] ; IPR001781[Zinc finger, LIM-type] ; IPR031847[Domain of unknown function DUF4749] -- -- A0A4E9FT70 IgG3 (Fragment) IGHG3 39 37.2 57.7 54.8 69 44.6 0.795130641330166 0.29899942134224 -0.330736177742086 Nonsignificant None -- -- immunoglobulin lambda-like polypeptide 1 -- -- -- -- -- IPR003597 [Immunoglobulin C1-set] -- -- Q6DVA0 LEM domain-containing protein 2 Lemd2 573.4 563.2 541 597.6 621.9 611.1 0.916420845624385 0.0126791797328616 -0.12591781920322 Nonsignificant None 1 Cellular Component:integral component of nuclear inner membrane (GO:0005639) -- -- -- -- -- -- IPR003887 [LEM domain] ; IPR018996[Inner nuclear membrane protein MAN1] -- -- Q3UKS6 Uncharacterized protein Mrpl40 550.7 556.5 729.7 721.9 650.6 659.5 0.903986220472441 0.359326972355171 -0.145627313184497 Nonsignificant None -- -- large subunit ribosomal protein L40 -- -- Mitochondrial ribosomal protein L28 J Translation, ribosomal structure and biogenesis ; IPR019192 [Ribosomal protein L28/L40, mitochondrial] -- -- Q9CXW2 28S ribosomal protein S22, mitochondrial Mrps22 988.8 998.4 1143.5 1027.8 1083.8 1022.7 0.998851418179498 0.983252779275657 -0.00165800565645187 Nonsignificant None -- -- small subunit ribosomal protein S22 -- -- Mitochondrial 28S ribosomal protein S22 J Translation, ribosomal structure and biogenesis ; IPR019374 [Ribosomal protein S22, mitochondrial] -- -- Q9JHS9 Spliceosome-associated protein CWC15 homolog Cwc15 1155.8 1360.1 614.1 507.2 552.6 460.2 2.05921052631579 0.135496914302118 1.04209133348903 Nonsignificant None 1 Cellular Component:spliceosomal complex (GO:0005681) protein CWC15 -- ko03040 Spliceosome Uncharacterized conserved protein S Function unknown ; IPR006973 [Pre-mRNA-splicing factor Cwf15/Cwc15] -- -- Q8R5K4 Nucleolar protein 6 Nol6 274 280.2 282.2 286 283.2 289.5 0.974030511237918 0.0725567970306355 -0.0379611298464843 Nonsignificant None -- -- U3 small nucleolar RNA-associated protein 22 -- ko03008 Ribosome biogenesis in eukaryotes Nucleolar RNA-associated protein (NRAP) S Function unknown ; IPR005554 [Nrap protein] -- -- A0A1L1SRX2 AMP deaminase Ampd3 668.7 636.4 746.2 693.8 682.1 677.2 0.999123276995762 0.987060551259724 -0.0012653987136166 Nonsignificant None 1 Molecular Function:deaminase activity (GO:0019239) AMP deaminase 3.5.4.6 ko00230 Purine metabolism ko01100 Metabolic pathways Adenosine monophosphate deaminase F Nucleotide transport and metabolism ; IPR001365 [Adenosine/AMP deaminase domain] -- -- Q6PG96 Ppl protein Ppl 226.6 215.3 183.5 152.9 153.8 185.6 1.27036359943124 0.0574896806321195 0.345241479690172 Nonsignificant None -- -- periplakin -- -- Dystonin, GAS (Growth-arrest-specific protein), and related proteins Z Cytoskeleton ; -- -- -- Q3UUT0 Eukaryotic translation initiation factor 4E type 2 Eif4e2 496.6 493.5 458.8 496.6 504.9 509.6 0.958837932631858 0.177860181474363 -0.0606411102459973 Nonsignificant None 4 Molecular Function:RNA binding (GO:0003723),Molecular Function:translation initiation factor activity (GO:0003743),Cellular Component:cytoplasm (GO:0005737),Biological Process:translational initiation (GO:0006413) translation initiation factor 4E -- ko01521 EGFR tyrosine kinase inhibitor resistance ko03013 RNA transport ko04066 HIF-1 signaling pathway ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04211 Longevity regulating pathway ko04910 Insulin signaling pathway Predicted mRNA cap-binding protein related to eIF-4E J Translation, ribosomal structure and biogenesis ; IPR001040 [Translation Initiation factor eIF- 4e] -- -- Q8BZ20 Protein mono-ADP-ribosyltransferase PARP12 Parp12 304.3 323.4 400.9 348 394.1 364.2 0.929765886287625 0.46981443130571 -0.105060601474598 Nonsignificant None 2 Molecular Function:NAD+ ADP-ribosyltransferase activity (GO:0003950),Molecular Function:metal ion binding (GO:0046872) poly [ADP-ribose] polymerase 7/11/12/13 2.4.2.30 -- -- -- -- IPR000571 [Zinc finger, CCCH-type] ; IPR004170[WWE domain] ; IPR012317[Poly(ADP-ribose) polymerase, catalytic domain] -- -- Q80TL7 Protein MON2 homolog Mon2 276 269.1 303.3 285.3 292.9 281.2 0.987200372352804 0.755408474560146 -0.0185851562433833 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR015403 [Sec7, C-terminal] ; IPR032629[Mon2, dimerisation and cyclophilin-binding domain] ; IPR032691[Guanine nucleotide exchange factor, N-terminal] ; IPR032817[Mon2, C-terminal] -- -- Q9D7M8 DNA-directed RNA polymerase II subunit RPB4 Polr2d 107.3 107.4 125.6 151.4 111.1 122.5 0.883896103896104 0.330016849182904 -0.178051294504618 Nonsignificant None 1 Molecular Function:DNA-directed 5'-3' RNA polymerase activity (GO:0003899) DNA-directed RNA polymerase II subunit RPB4 -- ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways ko03020 RNA polymerase ko05016 Huntington's disease ko05169 Epstein-Barr virus infection RNA polymerase II, fourth largest subunit K Transcription ; IPR005574 [RNA polymerase II, Rpb4] -- -- E9Q360 Integrator complex subunit 10 Ints10 379.4 362.4 352.2 344 367.6 375.6 1.00625459896983 0.863477123763859 0.00899537691252742 Nonsignificant None -- -- integrator complex subunit 10 -- -- -- -- -- -- -- -- Q9CXJ4 Mitochondrial potassium channel ATP-binding subunit Abcb8 329 305.3 306.1 306.7 306.2 330.1 0.997242841993637 0.941356964566854 -0.00398323190943739 Nonsignificant None 5 Molecular Function:ATP binding (GO:0005524),Biological Process:transport (GO:0006810),Cellular Component:integral component of membrane (GO:0016021),Molecular Function:ATPase activity (GO:0016887),Biological Process:transmembrane transport (GO:0055085) ATP-binding cassette, subfamily B (MDR/TAP), member 8 -- ko02010 ABC transporters Peptide exporter, ABC superfamily U Intracellular trafficking, secretion, and vesicular transport ; IPR003439 [ABC transporter-like] ; IPR011527[ABC transporter type 1, transmembrane domain] -- -- Q9CWE0 Mitochondrial fission regulator 1-like Mtfr1l 131.7 138.7 126.1 136.6 145 130.3 0.962612284535081 0.411553965094583 -0.0549732602769162 Nonsignificant None -- -- -- -- -- -- -- -- IPR007972 [Mitochondrial fission regulator 1] -- -- E9PX30 Mitogen-activated protein kinase kinase kinase kinase 5 Map4k5 691.3 655.8 582.8 510.6 525.5 522.2 1.23846499390361 0.0578751615765648 0.308553090356254 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) mitogen-activated protein kinase kinase kinase kinase 5 2.7.11.1 -- Mitogen-activated protein kinase kinase kinase kinase (MAP4K), germinal center kinase family T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR001180[Citron homology (CNH) domain] -- -- A0A0A6YXW6 Immunoglobulin heavy constant alpha (Fragment) Igha 344.5 280.7 496.5 297.8 777.2 358.6 0.782435825892857 0.559925298318784 -0.353955665478279 Nonsignificant None -- -- -- -- -- -- -- -- IPR003597 [Immunoglobulin C1-set] -- -- P05622 Platelet-derived growth factor receptor beta Pdgfrb 280.5 307.9 209.6 177.3 183.6 196.6 1.43139013452915 0.0548253564649855 0.517416941414679 Nonsignificant None 2 Molecular Function:protein kinase activity (GO:0004672),Biological Process:protein phosphorylation (GO:0006468) platelet-derived growth factor receptor beta 2.7.10.1 ko01521 EGFR tyrosine kinase inhibitor resistance ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04020 Calcium signaling pathway ko04060 Cytokine-cytokine receptor interaction ko04072 Phospholipase D signaling pathway ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04540 Gap junction ko04630 Jak-STAT signaling pathway ko04810 Regulation of actin cytoskeleton ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05200 Pathways in cancer ko05206 MicroRNAs in cancer ko05214 Glioma ko05215 Prostate cancer ko05218 Melanoma ko05230 Central carbon metabolism in cancer ko05231 Choline metabolism in cancer Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases T Signal transduction mechanisms ; IPR001245 [Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR013151[Immunoglobulin] -- -- O55033 Cytoplasmic protein NCK2 Nck2 332.5 330.5 368.2 387.7 401.1 329.6 0.922031473533619 0.311785817111199 -0.117112097013785 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) NCK adaptor protein 2 -- ko04012 ErbB signaling pathway ko04360 Axon guidance ko04660 T cell receptor signaling pathway Adaptor protein NCK/Dock, contains SH2 and SH3 domains T Signal transduction mechanisms ; IPR000980 [SH2 domain] ; IPR001452[SH3 domain] -- -- Q91YP0 L-2-hydroxyglutarate dehydrogenase, mitochondrial L2hgdh 533.6 575.1 663.3 643.4 638.1 662.1 0.911710228442066 0.215667453063134 -0.133352733674905 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) 2-hydroxyglutarate dehydrogenase 1.1.99.2 ko00650 Butanoate metabolism Predicted FAD-dependent oxidoreductase S Function unknown ; IPR006076 [FAD dependent oxidoreductase] -- -- A0A0U1RNL7 Protein-serine/threonine kinase Bckdk 206.7 200.2 327.8 368.4 352.7 366.2 0.675710475489745 0.103321813990206 -0.565522873599241 Nonsignificant None -- -- [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase 2.7.11.4 -- Dehydrogenase kinase T Signal transduction mechanisms ; IPR018955 [Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal] -- -- Q9WTQ8 Mitochondrial import inner membrane translocase subunit Tim23 Timm23 844.6 755.1 577 616.9 631.7 659.9 1.14052921142258 0.324521065903212 0.189703397666977 Nonsignificant None -- -- mitochondrial import inner membrane translocase subunit TIM23 -- Mitochondrial import inner membrane translocase, subunit TIM23 U Intracellular trafficking, secretion, and vesicular transport ; IPR003397 [Mitochondrial inner membrane translocase subunit Tim17/Tim22/Tim23/peroxisomal protein PMP24] -- -- Q91WK1 SPRY domain-containing protein 4 Spryd4 390.8 382.8 397 403.2 430.4 455.3 0.908216308480099 0.0647751433491116 -0.138892151989771 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR003877 [SPRY domain] -- -- Q9JKP8 Chromatin accessibility complex protein 1 Chrac1 358.4 372.8 333.6 290.4 266.8 278 1.27490421455939 0.00455178318172592 0.350388859342008 Nonsignificant None -- -- chromatin accessibility complex protein 1 -- -- CCAAT-binding factor, subunit C (HAP5) K Transcription ; IPR003958 [Transcription factor CBF/NF-Y/archaeal histone domain] -- NF-YC Q9CQX8 Alpha-ketoglutarate dehydrogenase component 4 Mrps36 828 846.1 910.5 853.6 865.9 945.8 0.969721982516039 0.520533519284555 -0.044356906284928 Nonsignificant None -- -- small subunit ribosomal protein S36 -- -- -- -- -- IPR020373 [Ribosomal protein S36, mitochondrial] -- -- E9QMY1 OX-2 membrane glycoprotein Cd200 689.2 682.3 705.8 675.1 665 708.2 1.01415808231216 0.549131335334777 0.0202825505582692 Nonsignificant None -- -- CD200 antigen -- -- -- -- -- IPR013151 [Immunoglobulin] -- -- A7L9Z8 Calcium-transporting ATPase type 2C member 2 Atp2c2 123.4 109.4 120.6 157.1 177.9 159.9 0.714083653263285 0.0037643912487442 -0.485835002315386 Nonsignificant None 2 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:metal ion binding (GO:0046872) Ca2+-transporting ATPase 3.6.3.8 -- Ca2+ transporting ATPase P Inorganic ion transport and metabolism ; IPR004014 [Cation-transporting P-type ATPase, N-terminal] ; IPR006068[Cation-transporting P-type ATPase, C-terminal] ; IPR008250[P-type ATPase, A domain] -- -- P35831 Tyrosine-protein phosphatase non-receptor type 12 Ptpn12 233.8 273.4 280 304.1 317 264.3 0.889089676982155 0.201527618583498 -0.169599152758626 Nonsignificant None 2 Molecular Function:protein tyrosine phosphatase activity (GO:0004725),Biological Process:protein dephosphorylation (GO:0006470) tyrosine-protein phosphatase non-receptor type 12/18/22 3.1.3.48 -- Protein tyrosine phosphatase T Signal transduction mechanisms ; IPR000242 [PTP type protein phosphatase] -- -- G3X9H5 Huntingtin Htt 274.1 287.8 295.1 306.7 320.7 323.4 0.901346234749685 0.0177226058751646 -0.149846698942572 Nonsignificant None -- -- huntingtin -- ko05016 Huntington's disease -- -- -- IPR024613 [Huntingtin, middle-repeat] -- -- P62077 Mitochondrial import inner membrane translocase subunit Tim8 B Timm8b 1019.8 1004.3 1028.7 1009.7 1018.8 999.9 1.00805705983358 0.416213947416214 0.0115773031325513 Nonsignificant None -- -- mitochondrial import inner membrane translocase subunit TIM8 -- -- Mitochondrial import inner membrane translocase, subunit TIM8 U Intracellular trafficking, secretion, and vesicular transport ; IPR004217 [Tim10/DDP family zinc finger] -- -- Q148P2 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial Oxsm 766.8 757 827.6 855.2 881.9 887.9 0.895771428571429 0.0197914648177171 -0.158797444004844 Nonsignificant None -- -- 3-oxoacyl-[acyl-carrier-protein] synthase II 2.3.1.179 ko00061 Fatty acid biosynthesis ko00780 Biotin metabolism ko01100 Metabolic pathways ko01212 Fatty acid metabolism 3-oxoacyl-(acyl-carrier-protein) synthase (I and II) IQ Lipid transport and metabolism ; Secondary metabolites biosynthesis, transport and catabolism ; IPR014030 [Beta-ketoacyl synthase, N-terminal] ; IPR014031[Beta-ketoacyl synthase, C-terminal] -- -- Q2M4I5 Sp3 (Fragment) Sp3 435.4 466.2 411.6 518.6 452.1 450.8 0.923812873724938 0.258111353707195 -0.114327443991909 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) transcription factor Sp3 -- -- FOG: Zn-finger R General function prediction only ; IPR007087 [Zinc finger, C2H2] -- zf-C2H2 P97825 Jupiter microtubule associated homolog 1 Jpt1 259.4 227 177.5 262.1 301.6 251.2 0.814701190330102 0.150051800661168 -0.295657078826331 Nonsignificant None -- -- -- -- -- -- -- -- IPR033335 [Microtubule-associated protein Jupiter/Hematological and neurological expressed 1] -- -- Q9DC70 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial Ndufs7 687.7 648.1 741.8 893.7 890 868 0.783497379039861 0.00250016727601645 -0.351999646293552 Nonsignificant None 2 Molecular Function:iron-sulfur cluster binding (GO:0051536),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease NADH-ubiquinone oxidoreductase, NUFS7/PSST/20 kDa subunit C Energy production and conversion ; IPR006137 [NADH:ubiquinone oxidoreductase-like, 20kDa subunit] -- -- W0UVF7 Ribonuclease A f3 Ear2 437.2 757.1 504.4 169.7 167.6 150.7 3.48094262295082 0.0530862564819095 1.79947803403674 Nonsignificant None -- -- -- -- -- -- -- -- IPR023412 [Ribonuclease A-domain] -- -- Q9R125 Ribonuclease 8 (Fragment) R8 293.5 463.6 307.4 117 122.2 107.4 3.07126370455857 0.047398903215903 1.61883239017949 Significant up -- -- -- -- -- -- -- -- IPR023412 [Ribonuclease A-domain] -- -- Q8BSK8 Ribosomal protein S6 kinase beta-1 Rps6kb1 272.6 260.2 257.4 246.3 239.9 242.1 1.08499244816696 0.0148643663208773 0.117685001167463 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) ribosomal protein S6 kinase beta 2.7.11.1 ko01521 EGFR tyrosine kinase inhibitor resistance ko01522 Endocrine resistance ko04012 ErbB signaling pathway ko04066 HIF-1 signaling pathway ko04140 Autophagy - animal ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04152 AMPK signaling pathway ko04211 Longevity regulating pathway ko04213 Longevity regulating pathway - multiple species ko04350 TGF-beta signaling pathway ko04371 Apelin signaling pathway ko04666 Fc gamma R-mediated phagocytosis ko04910 Insulin signaling pathway ko04931 Insulin resistance ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05212 Pancreatic cancer ko05221 Acute myeloid leukemia ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer ko05231 Choline metabolism in cancer Ribosomal protein S6 kinase and related proteins RT General function prediction only ; Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR017892[Protein kinase, C-terminal] -- -- A8Y5N8 Pleckstrin homology domain-containing family F member 2 (Fragment) Plekhf2 543.1 563.2 538.5 567 598.9 604.7 0.928950638201739 0.0397906684444909 -0.106326156959285 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) -- -- -- FYVE finger containing protein R General function prediction only ; IPR000306 [FYVE zinc finger] ; IPR001849[Pleckstrin homology domain] -- -- Q8R3F5 Malonyl-CoA-acyl carrier protein transacylase, mitochondrial Mcat 194.6 171.6 242.3 253.4 263.9 241.7 0.80171277997365 0.0826858595640838 -0.318842622701738 Nonsignificant None -- -- [acyl-carrier-protein] S-malonyltransferase 2.3.1.39 ko00061 Fatty acid biosynthesis ko01100 Metabolic pathways ko01212 Fatty acid metabolism Malonyl-CoA:ACP transacylase I Lipid transport and metabolism ; IPR014043 [Acyl transferase] -- -- Q3TLM9 Uncharacterized protein Ppp4r1 172.4 171.5 178.9 181.3 158.8 181.4 1.00249280920422 0.958729554183485 0.0035918883883053 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) serine/threonine-protein phosphatase 4 regulatory subunit 1 -- -- Protein phosphatase 2A regulatory subunit A and related proteins T Signal transduction mechanisms ; IPR000357 [HEAT repeat] -- -- E9QPK1 Cell growth regulator with EF hand domain protein 1 Cgref1 64.3 65.7 69.2 93 72.7 85.1 0.794258373205742 0.0475065289702991 -0.332319700733958 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q3TGL4 Uncharacterized protein Fbln2 453.2 454.1 386.3 400.1 377.6 383.2 1.11430786458782 0.132291584384336 0.156147880211347 Nonsignificant None 2 Molecular Function:calcium ion binding (GO:0005509),Cellular Component:extracellular region (GO:0005576) fibulin 1/2 -- -- Fibrillins and related proteins containing Ca2+-binding EGF-like domains T Signal transduction mechanisms ; IPR000020 [Anaphylatoxin/fibulin] ; IPR001881[EGF-like calcium-binding domain] ; IPR026823[Complement Clr-like EGF domain] -- -- B7ZNU5 Olfm4 protein Olfm4 540.7 759.3 493.7 356 369.3 377.1 1.62708635703919 0.105547296423324 0.702290823577079 Nonsignificant None -- -- -- -- -- -- -- -- IPR003112 [Olfactomedin-like domain] -- -- Q6NXI6 Regulation of nuclear pre-mRNA domain-containing protein 2 Rprd2 324.4 289.3 280.5 283.3 283.2 293.8 1.0394048587702 0.460753155758159 0.0557577081123761 Nonsignificant None -- -- -- -- -- Regulator of nuclear mRNA A RNA processing and modification ; IPR006903 [RNA polymerase II-binding domain] ; IPR032337[Cell-cycle alteration and expression-elevated protein in tumour] -- -- Q61189 Methylosome subunit pICln Clns1a 377.3 351.8 331.6 365.7 403.5 367.2 0.933386131643787 0.235690471208204 -0.0994540631513779 Nonsignificant None -- -- chloride channel, nucleotide-sensitive, 1A -- ko03013 RNA transport Chloride ion current inducer protein P Inorganic ion transport and metabolism ; -- -- -- Q923B6 Metalloreductase STEAP4 Steap4 247.9 291.9 237.4 221.6 236.3 233.6 1.12393347794649 0.173926762835204 0.168556649547488 Nonsignificant None -- -- metalloreductase STEAP4 1.16.1.- -- -- -- -- IPR013130 [Ferric reductase transmembrane component-like domain] ; IPR028939[Pyrroline-5-carboxylate reductase, catalytic, N-terminal] -- -- Q9QZH3 Peptidyl-prolyl cis-trans isomerase E Ppie 264.6 256.4 223.9 254 272.1 250.4 0.959304571796523 0.497281143744694 -0.0599391623766667 Nonsignificant None 4 Biological Process:protein peptidyl-prolyl isomerization (GO:0000413),Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:peptidyl-prolyl cis-trans isomerase activity (GO:0003755),Biological Process:protein folding (GO:0006457) peptidyl-prolyl isomerase E (cyclophilin E) 5.2.1.8 ko03040 Spliceosome Cyclophilin-type peptidyl-prolyl cis-trans isomerase O Posttranslational modification, protein turnover, chaperones ; IPR000504 [RNA recognition motif domain] ; IPR002130[Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain] -- -- Q8VCC1 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Hpgd 221 190.2 309.6 533 422.5 393.1 0.534480201690642 0.0197430661288599 -0.90379158651454 Significant down -- -- 15-hydroxyprostaglandin dehydrogenase (NAD) 1.1.1.141 ko05202 Transcriptional misregulation in cancer 15-hydroxyprostaglandin dehydrogenase and related dehydrogenases IR Lipid transport and metabolism ; General function prediction only ; IPR002347 [Short-chain dehydrogenase/reductase SDR] -- -- E9Q3M0 Mothers against decapentaplegic homolog Smad2 346.1 354.9 355.8 360.2 320.2 357.7 1.01801367883634 0.663745107023617 0.0257569467345931 Nonsignificant None 1 Cellular Component:intracellular (GO:0005622) mothers against decapentaplegic homolog 2/3 -- ko04068 FoxO signaling pathway ko04110 Cell cycle ko04144 Endocytosis ko04218 Cellular senescence ko04350 TGF-beta signaling pathway ko04371 Apelin signaling pathway ko04390 Hippo signaling pathway ko04520 Adherens junction ko04550 Signaling pathways regulating pluripotency of stem cells ko04659 Th17 cell differentiation ko04926 Relaxin signaling pathway ko04933 AGE-RAGE signaling pathway in diabetic complications ko05142 Chagas disease (American trypanosomiasis) ko05166 HTLV-I infection ko05200 Pathways in cancer ko05210 Colorectal cancer ko05212 Pancreatic cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer ko05321 Inflammatory bowel disease (IBD) TGFbeta receptor signaling protein SMAD and related proteins TK Signal transduction mechanisms ; Transcription ; IPR001132 [SMAD domain, Dwarfin-type] ; IPR003619[MAD homology 1, Dwarfin-type] -- MH1 G3UWX1 Replication factor C subunit 1 Rfc1 101.8 95.7 100.6 109.3 115.7 116.2 0.873681125439625 0.00774800740834498 -0.194821271327121 Nonsignificant None 4 Molecular Function:DNA clamp loader activity (GO:0003689),Molecular Function:ATP binding (GO:0005524),Cellular Component:DNA replication factor C complex (GO:0005663),Biological Process:DNA replication (GO:0006260) replication factor C subunit 1 -- ko03030 DNA replication ko03420 Nucleotide excision repair ko03430 Mismatch repair Replication factor C, subunit RFC1 (large subunit) L Replication, recombination and repair ; IPR001357 [BRCT domain] ; IPR003959[ATPase, AAA-type, core] ; IPR013725[DNA replication factor RFC1, C-terminal] -- -- Q3UV75 Non-specific serine/threonine protein kinase Ksr1 533.5 554.9 533.6 530.6 557.9 556.2 0.986198090837235 0.541170781699151 -0.0200506349324511 Nonsignificant None 2 Molecular Function:protein kinase activity (GO:0004672),Biological Process:protein phosphorylation (GO:0006468) kinase suppressor of Ras 1 -- ko04014 Ras signaling pathway ko05152 Tuberculosis Serine/threonine protein kinase RAF T Signal transduction mechanisms ; IPR001245 [Serine-threonine/tyrosine-protein kinase catalytic domain] -- -- Q9D211 CDKN2AIP N-terminal-like protein Cdkn2aipnl 446.1 414.1 391.2 349.3 355.7 358.6 1.17657013915006 0.0179213386337231 0.23458732684167 Nonsignificant None -- -- -- -- -- -- -- -- IPR021859 [XRN-Two Binding Domain, XTBD] -- -- Q91YT7 YTH domain-containing family protein 2 Ythdf2 923.9 868.6 607.5 543.8 576.1 624.9 1.37551581843191 0.0951795287556557 0.459972730742493 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) YTH domain-containing family protein -- -- Uncharacterized high-glucose-regulated protein R General function prediction only ; IPR007275 [YTH domain] -- -- Q9D0D5 General transcription factor IIE subunit 1 Gtf2e1 292.3 297.8 280.2 239.5 258.9 263 1.14302600472813 0.0152228054618668 0.192858226356892 Nonsignificant None -- -- transcription initiation factor TFIIE subunit alpha -- ko03022 Basal transcription factors ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis Transcription initiation factor IIE, alpha subunit K Transcription ; IPR013137 [Zinc finger, TFIIB-type] ; IPR021600[Transcription factor TFIIE alpha subunit, C-terminal] ; IPR024550[TFIIEalpha/SarR/Rpc3 HTH domain] -- -- B1ARD6 Schlafen family member 9 Slfn9 511 477.7 456.4 376.7 412.9 378.6 1.23703133025167 0.00952508767885939 0.306882039866683 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) -- -- -- -- -- -- IPR007421 [Schlafen, AAA domain] ; IPR018647[Domain of unknown function DUF2075] -- -- Q9EQ61 Pescadillo homolog Pes1 830.5 749 698.7 622.4 593.2 665.1 1.21135747328123 0.0387277598154284 0.276624669183368 Nonsignificant None 2 Cellular Component:nucleolus (GO:0005730),Biological Process:ribosome biogenesis (GO:0042254) pescadillo -- -- Protein required for normal rRNA processing A RNA processing and modification ; IPR001357 [BRCT domain] ; IPR010613[Pescadillo] -- -- A0A0R4J069 Selenocysteine lyase Scly 514.8 533.7 598.4 610.4 652.8 609.5 0.879425428525658 0.0607084533632544 -0.185366846306011 Nonsignificant None -- -- selenocysteine lyase 4.4.1.16 ko00450 Selenocompound metabolism ko01100 Metabolic pathways Cysteine desulfurase NFS1 E Amino acid transport and metabolism ; IPR000192 [Aminotransferase class V domain] -- -- Q3TXV4 Rab22B Rab31 278.8 269.4 276.7 280.1 302.9 271.5 0.965359859566998 0.37062991985117 -0.0508612552682968 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-22 -- ko04144 Endocytosis GTPase Rab5/YPT51 and related small G protein superfamily GTPases U Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- Q9CYD3 Cartilage-associated protein Crtap 1118.5 1110.6 1018.5 944.4 955 878 1.16929502412328 0.0174656079954995 0.225638981315146 Nonsignificant None -- -- cartilage-associated protein -- -- Membrane-associated proteoglycan Leprecan S Function unknown ; -- -- -- B2RTN5 Glucocorticoid receptor DNA binding factor 1 Arhgap35 297.3 275.7 262.7 299 324.4 319.8 0.886026293469042 0.0484255648646635 -0.17457858245635 Nonsignificant None 3 Molecular Function:GTP binding (GO:0005525),Biological Process:signal transduction (GO:0007165),Biological Process:small GTPase mediated signal transduction (GO:0007264) glucocorticoid receptor DNA-binding factor 1 -- ko04510 Focal adhesion ko04611 Platelet activation ko04670 Leukocyte transendothelial migration ko04810 Regulation of actin cytoskeleton Rho-GTPase activating protein T Signal transduction mechanisms ; IPR000198 [Rho GTPase-activating protein domain] ; IPR001806[Small GTPase superfamily] ; IPR002713[FF domain] ; IPR032835[Rho GTPase-activating protein, FF domain] -- -- Q80VY1 HZGJ-like protein 43.5 42.5 42.6 34.4 48.4 42.4 1.02715654952077 0.806417843234411 0.0386560803953291 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR001680 [WD40 repeat] -- -- Q9QZZ6 Dermatopontin Dpt 1000.6 989.7 929.2 1317.4 1199.7 1313.4 0.762172040203629 0.00241502871315055 -0.391811410116233 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q8BTV2 Cleavage and polyadenylation specificity factor subunit 7 Cpsf7 844.6 791.3 892.9 820.4 806.3 864.2 1.01521538399775 0.730025787927445 0.0217858362391584 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) cleavage and polyadenylation specificity factor subunit 6/7 -- ko03015 mRNA surveillance pathway mRNA cleavage factor I subunit/CPSF subunit A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- Q9D1E8 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon Agpat5 647.9 632.9 778.1 768.3 773 764.8 0.892806036164954 0.21553836122807 -0.163581313782306 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) lysophosphatidiate acyltransferase 2.3.1.51 ko00561 Glycerolipid metabolism ko00564 Glycerophospholipid metabolism ko01100 Metabolic pathways ko04072 Phospholipase D signaling pathway Lysophosphatidic acid acyltransferase LPAAT and related acyltransferases I Lipid transport and metabolism ; IPR002123 [Phospholipid/glycerol acyltransferase] ; IPR032098[Acyltransferase, C-terminal domain] -- -- O08691 Arginase-2, mitochondrial Arg2 189.5 160.2 177.5 147.4 163.6 168.2 1.10016694490818 0.205289913732784 0.137722462219266 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) arginase 3.5.3.1 ko00220 Arginine biosynthesis ko00330 Arginine and proline metabolism ko01100 Metabolic pathways ko01230 Biosynthesis of amino acids ko05146 Amoebiasis Arginase E Amino acid transport and metabolism ; IPR006035 [Ureohydrolase] -- -- Q3UYK7 SPARC-like protein 1 Sparcl1 514.1 501.8 347 273.7 278 304.5 1.59180098107919 0.0364996969470235 0.670659970580979 Significant up 4 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:protein binding (GO:0005515),Cellular Component:proteinaceous extracellular matrix (GO:0005578),Biological Process:signal transduction (GO:0007165) -- -- -- -- -- -- IPR002350 [Kazal domain] ; IPR015369[Follistatin/Osteonectin EGF domain] ; IPR019577[SPARC/Testican, calcium-binding domain] -- -- Q3TLQ5 Uncharacterized protein Chmp4c 339.1 327.9 316.8 407.5 396.2 391.5 0.823125836680054 0.000916112483957983 -0.280815093065909 Nonsignificant None 1 Biological Process:vacuolar transport (GO:0007034) charged multivesicular body protein 4 -- ko04144 Endocytosis ko04217 Necroptosis Protein involved in glucose derepression and pre-vacuolar endosome protein sorting U Intracellular trafficking, secretion, and vesicular transport ; IPR005024 [Snf7 family] -- -- A0A0A0MQ70 Solute carrier family 25 member 35 Slc25a35 388.3 410 476.7 667 608.9 633.5 0.667749031109249 0.00255691402327363 -0.582622117347675 Nonsignificant None -- -- solute carrier family 25, member 34/35 -- -- Mitochondrial oxaloacetate carrier protein C Energy production and conversion ; IPR018108 [Mitochondrial substrate/solute carrier] -- -- O35083 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha Agpat1 487.8 461.7 413 444.9 505.8 487.2 0.947562417414285 0.425779769881968 -0.0777071159011055 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) lysophosphatidate acyltransferase 2.3.1.51 ko00561 Glycerolipid metabolism ko00564 Glycerophospholipid metabolism ko01100 Metabolic pathways ko04072 Phospholipase D signaling pathway ko04975 Fat digestion and absorption 1-acyl-sn-glycerol-3-phosphate acyltransferase I Lipid transport and metabolism ; IPR002123 [Phospholipid/glycerol acyltransferase] -- -- A2AUF7 Rab9 effector protein with kelch motifs Rabepk 454.6 421.6 443.2 404 410.3 476.4 1.02223599597118 0.722431045507532 0.0317282989304845 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) Rab9 effector protein with kelch motifs -- -- Kelch repeat-containing proteins R General function prediction only ; IPR006652 [Kelch repeat type 1] ; IPR011498[Kelch repeat type 2] -- -- Q3UHE7 Kinesin motor domain-containing protein Kif21a 364.4 384.3 300.3 358.8 366.2 388.8 0.941820793679296 0.467011691615346 -0.0864755198323817 Nonsignificant None 5 Molecular Function:microtubule motor activity (GO:0003777),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Biological Process:microtubule-based movement (GO:0007018),Molecular Function:microtubule binding (GO:0008017) kinesin family member 4/21/27 -- -- Kinesin-like protein Z Cytoskeleton ; IPR001680 [WD40 repeat] ; IPR001752[Kinesin motor domain] -- -- Q5HZH8 MAD2 mitotic arrest deficient-like 1 (Yeast) Mad2l1 373.1 357.6 348.9 318.3 288 307.9 1.18092321155108 0.00832556149169181 0.239915157862817 Nonsignificant None -- -- mitotic spindle assembly checkpoint protein MAD2 -- ko04110 Cell cycle ko04114 Oocyte meiosis ko04914 Progesterone-mediated oocyte maturation ko05166 HTLV-I infection Spindle assembly checkpoint protein DZ Cell cycle control, cell division, chromosome partitioning ; Cytoskeleton ; IPR003511 [HORMA domain] -- -- Q571E0 Pre-mRNA-splicing regulator WTAP (Fragment) Wtap 479.1 443.8 252.2 260.1 249.9 257 1.53207301173403 0.193192640705704 0.615485051281607 Nonsignificant None 2 Cellular Component:nucleus (GO:0005634),Biological Process:mRNA methylation (GO:0080009) -- -- -- Splicing regulator A RNA processing and modification ; IPR029732 [WTAP/Mum2 family] -- -- Q3TUQ8 Poly(A)-specific ribonuclease PARN Parn 417.8 391.2 459.1 384.9 422.3 426.1 1.02821697883727 0.650523987957781 0.0401447404668551 Nonsignificant None 8 Biological Process:nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289),Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:RNA binding (GO:0003723),Molecular Function:poly(A)-specific ribonuclease activity (GO:0004535),Cellular Component:nucleus (GO:0005634),Cellular Component:cytoplasm (GO:0005737),Biological Process:mRNA catabolic process (GO:0006402),Molecular Function:metal ion binding (GO:0046872) poly(A)-specific ribonuclease 3.1.13.4 ko03018 RNA degradation Poly(A)-specific exoribonuclease PARN L Replication, recombination and repair ; IPR001374 [R3H domain] ; IPR006941[Ribonuclease CAF1] ; IPR014789[Poly(A)-specific ribonuclease, RNA-binding] -- -- Z4YM84 Acyl-CoA-binding domain-containing protein 5 Acbd5 639.7 555.8 585.2 562.1 595.4 553.5 1.04073641145529 0.448825609004963 0.0576047218179835 Nonsignificant None 1 Molecular Function:fatty-acyl-CoA binding (GO:0000062) -- -- -- Acyl-CoA-binding protein I Lipid transport and metabolism ; IPR000582 [Acyl-CoA-binding protein, ACBP] -- -- A0A0R4J0S3 Reticulon-4-interacting protein 1, mitochondrial Rtn4ip1 546.7 514.7 483.8 471.6 438.5 492.4 1.10174688057041 0.118546406464716 0.139792811848414 Nonsignificant None 1 Biological Process:oxidation-reduction process (GO:0055114) -- -- -- Zinc-binding oxidoreductase CR Energy production and conversion ; General function prediction only ; IPR013154 [Alcohol dehydrogenase, N-terminal] -- -- Q9Z0G2 SRSF protein kinase 3 Srpk3 9 9.1 6.9 5.7 10.5 10 0.954198473282443 0.823907053613042 -0.0676387168753634 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) serine/threonine-protein kinase SRPK3 2.7.11.1 -- Serine/threonine protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q62074 Protein kinase C iota type Prkci 484.1 452.4 462.1 503.3 535.1 514.7 0.900521537570021 0.0175560600114676 -0.151167313732061 Nonsignificant None 6 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468),Biological Process:intracellular signal transduction (GO:0035556) atypical protein kinase C iota type 2.7.11.13 ko04015 Rap1 signaling pathway ko04144 Endocytosis ko04390 Hippo signaling pathway ko04530 Tight junction ko04611 Platelet activation ko04910 Insulin signaling pathway ko05165 Human papillomavirus infection Serine/threonine protein kinase T Signal transduction mechanisms ; IPR000270 [PB1 domain] ; IPR000719[Protein kinase domain] ; IPR002219[Protein kinase C-like, phorbol ester/diacylglycerol-binding domain] ; IPR017892[Protein kinase, C-terminal] -- -- Q3V493 Trafficking protein particle complex subunit Trappc4 370.7 354.4 371.2 373.5 387.1 411.4 0.935409556313993 0.111226423375176 -0.0963299272205423 Nonsignificant None 2 Biological Process:transport (GO:0006810),Cellular Component:TRAPP complex (GO:0030008) trafficking protein particle complex subunit 4 -- -- Transport protein particle (TRAPP) complex subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR007233 [Trafficking protein particle complex subunit] -- -- Q5F283 Phospholipid scramblase Plscr3 292.3 281.5 228 226.3 198.5 224.8 1.23429802955665 0.0808072113205626 0.303690784965594 Nonsignificant None -- -- -- -- -- Phospholipid scramblase M Cell wall/membrane/envelope biogenesis ; IPR005552 [Scramblase] -- -- P49442 Inositol polyphosphate 1-phosphatase Inpp1 364.4 371.7 403.6 456.5 455.6 437.3 0.844597598932859 0.00672960250802791 -0.243663949112794 Nonsignificant None 1 Biological Process:phosphatidylinositol phosphorylation (GO:0046854) inositol polyphosphate 1-phosphatase 3.1.3.57 ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system Bisphosphate 3'-nucleotidase BPNT1/Inositol polyphosphate 1-phosphatase F Nucleotide transport and metabolism ; IPR000760 [Inositol monophosphatase-like] -- -- G5E881 Phosphatidate cytidylyltransferase, mitochondrial Tamm41 536.2 504.8 519.6 534.5 526.4 532.3 0.979538036655787 0.31139657328854 -0.0298265797000383 Nonsignificant None -- -- mitochondrial translocator assembly and maintenance protein 41 -- -- Uncharacterized conserved protein S Function unknown ; IPR015222 [Mitochondrial matrix Mmp37] -- -- Q8K1A6 Coiled-coil and C2 domain-containing protein 1A Cc2d1a 370.4 359 383.3 330.1 335.4 350.9 1.09474616292798 0.026836027725949 0.130596393170811 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) coiled-coil and C2 domain-containing protein 1 -- -- Uncharacterized conserved protein, contains DM14 and C2 domains R General function prediction only ; IPR000008 [C2 domain] -- -- Q8K3A9 7SK snRNA methylphosphate capping enzyme Mepce 1086.3 1024.8 1097.6 917.9 916 919.9 1.16518991938412 0.021315818672663 0.220565125199341 Nonsignificant None 1 Molecular Function:methyltransferase activity (GO:0008168) 7SK snRNA methylphosphate capping enzyme 2.1.1.- -- Predicted methyltransferase R General function prediction only ; IPR010675 [RNA methyltransferase bin3, C-terminal] ; IPR025714[Methyltransferase domain] -- -- Q9R0M6 Ras-related protein Rab-9A Rab9a 219.9 204.7 240.1 254.8 234.2 238 0.914305364511692 0.159894698737603 -0.129252010249265 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-9A -- ko05162 Measles Ras-related GTPase R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- Q812E0 Cytoplasmic polyadenylation element-binding protein 2 Cpeb2 263.8 237.2 263.8 248.1 283 259.8 0.966999620685295 0.555972330877977 -0.0484127710958464 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) cytoplasmic polyadenylation element-binding protein -- ko04114 Oocyte meiosis ko04914 Progesterone-mediated oocyte maturation Predicted RNA-binding protein (RRM superfamily) J Translation, ribosomal structure and biogenesis ; IPR000504 [RNA recognition motif domain] ; IPR032296[Cytoplasmic polyadenylation element-binding protein, ZZ domain] -- -- A2N494 Aberrantly recombined kappa chain Vk8/J1 region (Fragment) 584.9 530.5 353.6 310.2 290 374.8 1.50666666666667 0.0911681164784385 0.591360271919307 Nonsignificant None -- -- pre-B lymphocyte gene -- -- -- -- -- IPR013106 [Immunoglobulin V-set domain] -- -- Q9WUX5 Inositol 1,4,5-triphosphate receptor associated 1 Irag1 210.3 245.8 265.4 279.9 307.1 287.7 0.824854235737967 0.0473035508350898 -0.277788899114236 Nonsignificant None -- -- inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate -- ko04022 cGMP-PKG signaling pathway ko04270 Vascular smooth muscle contraction -- -- -- IPR008677 [MRVI1] -- -- Q8BYW9 EGF domain-specific O-linked N-acetylglucosamine transferase Eogt 757.4 738.2 970.4 943.4 880.1 1037.7 0.86187613588704 0.206085196025179 -0.214447546897414 Nonsignificant None -- -- protein O-GlcNAc transferase 2.4.1.255 ko00514 Other types of O-glycan biosynthesis Uncharacterized conserved protein S Function unknown ; IPR007657 [Glycosyltransferase 61] -- -- D3Z6F0 Interferon-induced protein with tetratricpeptide repeats 1B-like 1 Ifit1bl1 271.9 268 345.9 414.2 504.7 475.5 0.635255306942054 0.00996758439506105 -0.654591572240369 Significant down 1 Molecular Function:protein binding (GO:0005515) interferon-induced protein with tetratricopeptide repeats 1 -- ko05160 Hepatitis C ko05168 Herpes simplex infection FOG: TPR repeat R General function prediction only ; IPR019734 [Tetratricopeptide repeat] -- -- Q8CI95 Oxysterol-binding protein-related protein 11 Osbpl11 220.9 195 225.8 188.5 207.9 216.4 1.04716057441253 0.488063470052103 0.0664826859612432 Nonsignificant None -- -- oxysterol-binding protein-related protein 9/10/11 -- -- Oxysterol-binding protein T Signal transduction mechanisms ; IPR000648 [Oxysterol-binding protein] ; IPR001849[Pleckstrin homology domain] -- -- A0A0R4J092 Beta-mannosidase Manba 300.7 336.3 348.9 438.4 435.2 443.9 0.74831119544592 0.00165501412177916 -0.418289735522407 Nonsignificant None 1 Biological Process:carbohydrate metabolic process (GO:0005975) beta-mannosidase 3.2.1.25 ko00511 Other glycan degradation ko04142 Lysosome Predicted beta-mannosidase G Carbohydrate transport and metabolism ; IPR006103 [Glycoside hydrolase family 2, catalytic domain] ; IPR006104[Glycosyl hydrolases family 2, sugar binding domain] -- -- Q9D3U0 tRNA pseudouridine synthase Pus10 Pus10 577.8 539 524.8 489.9 545.6 518.7 1.05623471882641 0.26637754012424 0.0789304692217194 Nonsignificant None -- -- tRNA pseudouridine synthase 10 5.4.99.25 -- Predicted pseudouridylate synthase J Translation, ribosomal structure and biogenesis ; -- -- -- P70452 Syntaxin-4 Stx4 377.9 341.7 397.3 496.6 457.6 539.4 0.747790573111944 0.0119142859476428 -0.419293810653533 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:membrane (GO:0016020) syntaxin 4 -- ko04130 SNARE interactions in vesicular transport ko04962 Vasopressin-regulated water reabsorption SNARE protein Syntaxin 1 and related proteins U Intracellular trafficking, secretion, and vesicular transport ; IPR000727 [Target SNARE coiled-coil homology domain] ; IPR006011[Syntaxin, N-terminal domain] -- -- Q80U95 Ubiquitin-protein ligase E3C Ube3c 149.4 191.3 162.9 143.3 153.5 135.5 1.16493176035161 0.150858421594616 0.220245446823113 Nonsignificant None 1 Molecular Function:ubiquitin-protein transferase activity (GO:0004842) ubiquitin-protein ligase E3 C 2.3.2.26 ko04120 Ubiquitin mediated proteolysis E3 ubiquitin protein ligase O Posttranslational modification, protein turnover, chaperones ; IPR000569 [HECT domain] -- -- O35435 Dihydroorotate dehydrogenase (quinone), mitochondrial Dhodh 274.1 278.7 275.6 302.8 307.5 319.5 0.890944289094429 0.00279462126152932 -0.166592872298452 Nonsignificant None 2 Cellular Component:cytoplasm (GO:0005737),Biological Process:oxidation-reduction process (GO:0055114) dihydroorotate dehydrogenase 1.3.5.2 ko00240 Pyrimidine metabolism ko01100 Metabolic pathways Dihydroorotate dehydrogenase F Nucleotide transport and metabolism ; IPR005720 [Dihydroorotate dehydrogenase domain] -- -- Q8BKR5 Protein phosphatase 1 regulatory subunit 37 Ppp1r37 213.4 229.2 226.7 222.7 236.1 220.7 0.984988962472406 0.64736099118386 -0.0218205366894569 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) protein phosphatase 1 regulatory subunit 37 -- -- Ribonuclease inhibitor type leucine-rich repeat proteins A RNA processing and modification ; IPR001611 [Leucine-rich repeat] -- -- Q3TBA3 Antigen peptide transporter 1 Tap1 327.5 354.6 288.2 346.8 363.4 315 0.946449473273508 0.4872466470274 -0.079402605972084 Nonsignificant None 5 Molecular Function:ATP binding (GO:0005524),Biological Process:transport (GO:0006810),Cellular Component:integral component of membrane (GO:0016021),Molecular Function:ATPase activity (GO:0016887),Biological Process:transmembrane transport (GO:0055085) ATP-binding cassette, subfamily B (MDR/TAP), member 2 -- ko02010 ABC transporters ko04145 Phagosome ko04612 Antigen processing and presentation ko05168 Herpes simplex infection ko05340 Primary immunodeficiency Peptide exporter, ABC superfamily U Intracellular trafficking, secretion, and vesicular transport ; IPR003439 [ABC transporter-like] ; IPR011527[ABC transporter type 1, transmembrane domain] -- -- E9QMH7 Inhibitor of nuclear factor kappa-B kinase-interacting protein Ikbip 751.3 783.7 732.5 685.7 728.3 567.8 1.14416187304471 0.131117676545839 0.194291175296566 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- P70388 DNA repair protein RAD50 Rad50 539.6 491 516.3 522 541 591.1 0.93519134272414 0.225113198983594 -0.0966665203073153 Nonsignificant None -- -- DNA repair protein RAD50 3.6.-.- ko03440 Homologous recombination ko03450 Non-homologous end-joining ko04218 Cellular senescence DNA repair protein RAD50, ABC-type ATPase/SMC superfamily L Replication, recombination and repair ; IPR013134 [RAD50, zinc hook] -- -- E9Q9H3 DnaJ homolog subfamily C member 2 Dnajc2 730.8 783.5 741.6 798.4 820.3 752.3 0.951455082243779 0.209597846771553 -0.0717925457488372 Nonsignificant None -- -- DnaJ homolog subfamily C member 2 -- -- Zuotin and related molecular chaperones (DnaJ superfamily), contains DNA-binding domains O Posttranslational modification, protein turnover, chaperones ; IPR001005 [SANT/Myb domain] ; IPR001623[DnaJ domain] ; IPR032003[Ribosome-associated complex head domain] -- MYB Q3UG63 CUE domain-containing protein Ascc2 211.9 196.3 212.4 207.6 224.1 215.8 0.958455598455598 0.276084487800423 -0.0612164959325595 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) activating signal cointegrator complex subunit 2 -- -- Transcription coactivator complex, P100 component K Transcription ; IPR003892 [Ubiquitin system component Cue] -- -- B1AVK5 Collagen, type IV, alpha 6 Col4a6 927.1 957.2 1221 1259.2 1318.9 1227.1 0.816067486597288 0.0742454441455966 -0.293239630738005 Nonsignificant None 2 Molecular Function:extracellular matrix structural constituent (GO:0005201),Cellular Component:collagen trimer (GO:0005581) collagen, type IV, alpha -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04926 Relaxin signaling pathway ko04933 AGE-RAGE signaling pathway in diabetic complications ko04974 Protein digestion and absorption ko05146 Amoebiasis ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05222 Small cell lung cancer Collagens (type IV and type XIII), and related proteins W Extracellular structures ; IPR001442 [Collagen IV, non-collagenous] ; IPR008160[Collagen triple helix repeat] -- -- A0A0A0MQC7 Microtubule-associated protein Mapt 645.9 610.4 627.3 750 719.6 733 0.855171161354763 0.0014077935448581 -0.225714892521176 Nonsignificant None 1 Molecular Function:tubulin binding (GO:0015631) microtubule-associated protein tau -- ko04010 MAPK signaling pathway ko05010 Alzheimer's disease Microtubule-associated protein TAU Z Cytoskeleton ; IPR001084 [Microtubule associated protein, tubulin-binding repeat] -- -- F7C0H6 CB1 cannabinoid receptor-interacting protein 1 (Fragment) Cnrip1 415.6 420.6 439.3 442.7 430 447.6 0.966068317806559 0.169328012060112 -0.0498028786258677 Nonsignificant None -- -- -- -- -- -- -- -- IPR029204 [CB1 cannabinoid receptor-interacting protein 1] -- -- Q8BH57 WD repeat-containing protein 48 Wdr48 597.5 643.1 726.7 694.4 708.2 708.9 0.931707317073171 0.331265317066582 -0.102051271469697 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) WD repeat-containing protein 48 -- ko03460 Fanconi anemia pathway Conserved WD40 repeat-containing protein S Function unknown ; IPR001680 [WD40 repeat] ; IPR021772[Protein of unknown function DUF3337] -- -- Q9CQV1 Mitochondrial import inner membrane translocase subunit TIM16 Pam16 394.9 376.9 366.5 377.7 337.5 375.7 1.04345036208635 0.365348857395254 0.061361971772143 Nonsignificant None -- -- mitochondrial import inner membrane translocase subunit TIM16 -- -- Uncharacterized conserved protein S Function unknown ; -- -- -- Q9ER39 Torsin-1A Tor1a 340.5 368.7 353.6 313.6 348.1 347.7 1.05290271448385 0.273635581598356 0.0743721411920798 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) -- -- -- ATPase of the AAA+ superfamily R General function prediction only ; IPR010448 [Torsin] -- -- J3QNE8 Putative sodium-coupled neutral amino acid transporter 10 Slc38a10 288.6 263.7 259.1 236.7 232.6 240.2 1.14362226920366 0.0226633106263137 0.193610618258359 Nonsignificant None -- -- solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 10 -- -- Amino acid transporter protein E Amino acid transport and metabolism ; IPR013057 [Amino acid transporter, transmembrane domain] -- -- Q8CD57 FAS-associated death domain protein Fadd 117.2 108.7 100 109.1 128.1 100.9 0.963916001183082 0.689519067962311 -0.0530206641548131 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Biological Process:signal transduction (GO:0007165),Biological Process:regulation of apoptotic process (GO:0042981) FAS-associated death domain protein -- ko01524 Platinum drug resistance ko04210 Apoptosis ko04215 Apoptosis - multiple species ko04217 Necroptosis ko04620 Toll-like receptor signaling pathway ko04621 NOD-like receptor signaling pathway ko04622 RIG-I-like receptor signaling pathway ko04657 IL-17 signaling pathway ko04668 TNF signaling pathway ko05010 Alzheimer's disease ko05142 Chagas disease (American trypanosomiasis) ko05152 Tuberculosis ko05161 Hepatitis B ko05165 Human papillomavirus infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection ko05200 Pathways in cancer -- -- -- IPR000488 [Death domain] ; IPR001875[Death effector domain] -- -- Q80ZK0 28S ribosomal protein S10, mitochondrial Mrps10 694.1 721.8 816.3 784.6 914.1 806.5 0.891026664537761 0.170275903699497 -0.166459488930526 Nonsignificant None -- -- small subunit ribosomal protein S10 -- ko03010 Ribosome Mitochondrial ribosomal protein S10 J Translation, ribosomal structure and biogenesis ; IPR027486 [Ribosomal protein S10 domain] -- -- F7BCN0 COMM domain-containing protein 1 (Fragment) Commd1b 51.9 46.9 40.1 49.9 55 52.6 0.881904761904762 0.17120990414069 -0.181305229293249 Nonsignificant None -- -- -- -- -- -- -- -- IPR017920 [COMM domain] ; IPR033776[COMMD1 N-terminal domain] -- -- Q99PW4 EKC/KEOPS complex subunit Tp53rkb Tp53rkb 39.5 38.1 49.7 47.4 48.6 47.9 0.884642112578179 0.268721975423597 -0.17683417283894 Nonsignificant None 2 Molecular Function:ATP binding (GO:0005524),Cellular Component:membrane (GO:0016020) TP53 regulating kinase and related kinases 2.7.11.1 -- Serine/threonine protein kinase R General function prediction only ; IPR010440 [Lipopolysaccharide kinase] -- -- Q3TVW6 Uncharacterized protein Lmcd1 190.2 199 147.5 181.8 178.1 190.8 0.974577810059924 0.789429668137207 -0.0371507203778138 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) -- -- -- FOG: LIM domain TZR Signal transduction mechanisms ; Cytoskeleton ; General function prediction only ; IPR001781 [Zinc finger, LIM-type] ; IPR010442[PET domain] -- -- Q3UWC0 Uncharacterized protein Nxpe4 334.1 328.2 298.7 506.2 735.8 742.2 0.484326176796694 0.0456431481677244 -1.04594911525116 Significant down -- -- -- -- -- -- -- -- IPR026845 [Neurexophilin/NXPE] -- -- Q62467 Sodium channel protein Scn7a 180.8 171.8 198.1 260.3 276.9 321.2 0.641542404473439 0.00654261632169197 -0.640383467605644 Significant down 7 Cellular Component:voltage-gated sodium channel complex (GO:0001518),Molecular Function:ion channel activity (GO:0005216),Molecular Function:voltage-gated sodium channel activity (GO:0005248),Biological Process:ion transport (GO:0006811),Biological Process:sodium ion transport (GO:0006814),Cellular Component:membrane (GO:0016020),Biological Process:transmembrane transport (GO:0055085) voltage-gated sodium channel type VII alpha -- ko04261 Adrenergic signaling in cardiomyocytes Voltage-gated Ca2+ channels, alpha1 subunits PT Inorganic ion transport and metabolism ; Signal transduction mechanisms ; IPR005821 [Ion transport domain] ; IPR010526[Sodium ion transport-associated] -- -- Q69ZR9 Protein TASOR Tasor 231.2 226.8 220.6 235.3 236.8 232.3 0.963373083475298 0.0620207924706252 -0.0538334791202318 Nonsignificant None -- -- protein TASOR -- -- -- -- -- IPR022188 [Protein of unknown function DUF3715] -- -- Q9D7E3 Esterase OVCA2 Ovca2 644 594 572.3 533.2 540.2 682 1.03127492309445 0.746910908666711 0.0444289857732712 Nonsignificant None -- -- -- -- -- Phospholipase/carboxyhydrolase E Amino acid transport and metabolism ; IPR005645 [Serine hydrolase FSH] -- -- A2AKA9 Bromodomain-containing protein 3 (Fragment) Brd3 390.6 393.3 434.7 376.9 387.9 390.9 1.05442588907156 0.231928554484899 0.0764576980464472 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) bromodomain-containing protein 3 -- -- Transcription initiation factor TFIID, subunit BDF1 and related bromodomain proteins K Transcription ; IPR001487 [Bromodomain] ; IPR027353[NET domain] -- -- A0A494B9Q5 CWF19-like protein 1 (Fragment) Cwf19l1 987.3 1108.7 907.2 827.9 874 837 1.18287447319705 0.0620511543311799 0.242296982802991 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; -- -- -- Q80SZ7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 Gng5 761.6 715.3 887.7 770.8 794.7 710.5 1.03892794376098 0.633340108867289 0.0550955976650456 Nonsignificant None 3 Molecular Function:signal transducer activity (GO:0004871),Cellular Component:heterotrimeric G-protein complex (GO:0005834),Biological Process:G-protein coupled receptor signaling pathway (GO:0007186) guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 -- ko04014 Ras signaling pathway ko04062 Chemokine signaling pathway ko04151 PI3K-Akt signaling pathway ko04371 Apelin signaling pathway ko04713 Circadian entrainment ko04723 Retrograde endocannabinoid signaling ko04724 Glutamatergic synapse ko04725 Cholinergic synapse ko04726 Serotonergic synapse ko04727 GABAergic synapse ko04728 Dopaminergic synapse ko04926 Relaxin signaling pathway ko05032 Morphine addiction ko05034 Alcoholism ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05200 Pathways in cancer G protein gamma subunit T Signal transduction mechanisms ; IPR015898 [G-protein gamma-like domain] -- -- Q8CHT3 Integrator complex subunit 5 Ints5 195.3 187.4 194.3 153.1 158.8 176.6 1.18116683725691 0.0170578964236847 0.240212756677097 Nonsignificant None -- -- integrator complex subunit 5 -- -- -- -- -- IPR029444 [Integrator complex subunit 5, C-terminal] ; IPR029445[Integrator complex subunit 5, N-terminal] -- -- Q9ESU6 Bromodomain-containing protein 4 Brd4 243.5 248.4 237.9 242.4 223.2 236.9 1.03886120996441 0.231978453138069 0.0550029255888309 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) bromodomain-containing protein 4 -- -- Transcription initiation factor TFIID, subunit BDF1 and related bromodomain proteins K Transcription ; IPR001487 [Bromodomain] ; IPR027353[NET domain] ; IPR031354[Bromodomain protein 4, C-terminal] -- -- Q8K1X4 Nck-associated protein 1-like Nckap1l 689.2 719.2 592.4 548.1 573 585 1.17273313404841 0.0689580468420192 0.229874752507582 Nonsignificant None -- -- NCK-associated protein 1 -- ko04810 Regulation of actin cytoskeleton Membrane-associated hematopoietic protein R General function prediction only ; IPR019137 [Nck-associated protein 1] -- -- Q9ET78 Junctophilin-2 Jph2 1271.5 1310.2 1193.5 1173.9 1215 1157.8 1.06442608622099 0.117712414167387 0.0900757724818842 Nonsignificant None -- -- junctophilin -- -- Junctional membrane complex protein Junctophilin and related MORN repeat proteins R General function prediction only ; IPR003409 [MORN motif] -- -- Q6NVD0 FRAS1-related extracellular matrix protein 2 Frem2 400.3 411 425.3 376.3 418.2 351.9 1.07868108862526 0.219468966199462 0.109268395998267 Nonsignificant None 2 Biological Process:cell communication (GO:0007154),Cellular Component:integral component of membrane (GO:0016021) -- -- -- Proteoglycan R General function prediction only ; IPR003644 [Na-Ca exchanger/integrin-beta4] -- -- D3YYN3 Ribosomal RNA-processing protein 43 (Fragment) Exosc8 135.7 125.8 116.8 124.8 154.6 119.6 0.94812030075188 0.601716690162659 -0.0768579700603321 Nonsignificant None -- -- exosome complex component RRP43 -- ko03018 RNA degradation Exosomal 3'-5' exoribonuclease complex, subunit Rrp43 J Translation, ribosomal structure and biogenesis ; IPR001247 [Exoribonuclease, phosphorolytic domain 1] -- -- Q9JLZ8 Single Ig IL-1-related receptor Sigirr 513 499.2 477.2 621 636.3 596.5 0.80343079080807 0.00146345729201803 -0.315754342372686 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Biological Process:signal transduction (GO:0007165) single Ig IL-1R-related molecule -- -- -- -- -- IPR000157 [Toll/interleukin-1 receptor homology (TIR) domain] ; IPR007110[Immunoglobulin-like domain] -- -- P54265 Myotonin-protein kinase Dmpk 90.2 90.3 159.4 145.5 135.4 113.8 0.86116037496833 0.503451858156881 -0.215646157351431 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) dystrophia myotonica-protein kinase 2.7.11.1 -- Rho-associated, coiled-coil containing protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR014930[Myotonic dystrophy protein kinase, coiled coil] -- -- O35134 DNA-directed RNA polymerase I subunit RPA1 Polr1a 198.8 205 184.1 164 195.8 174.6 1.1001122754491 0.187042358399506 0.137650770084207 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Molecular Function:DNA-directed 5'-3' RNA polymerase activity (GO:0003899) DNA-directed RNA polymerase I subunit RPA1 2.7.7.6 ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways ko03020 RNA polymerase RNA polymerase I, large subunit K Transcription ; IPR000722 [RNA polymerase, alpha subunit] ; IPR007066[RNA polymerase Rpb1, domain 3] ; IPR007080[RNA polymerase Rpb1, domain 1] ; IPR007081[RNA polymerase Rpb1, domain 5] ; IPR007083[RNA polymerase Rpb1, domain 4] -- -- Q9D7M1 Glucose-induced degradation protein 8 homolog Gid8 560.4 516.9 460.2 475.2 498.1 538 1.01733606828558 0.811706394876711 0.0247963399212174 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- LisH motif-containing protein Z Cytoskeleton ; IPR006594 [LIS1 homology motif] ; IPR024964[CTLH/CRA C-terminal to LisH motif domain] -- -- Q61466 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 Smarcd1 126.3 112.9 83 77.3 100.5 99.4 1.16233766233766 0.369959826953686 0.217029236569355 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D -- ko05225 Hepatocellular carcinoma SWI/SNF transcription activation complex subunit BK Chromatin structure and dynamics ; Transcription ; IPR003121 [SWIB/MDM2 domain] -- -- Q8VC49 Interferon alpha-inducible protein 27-like protein 2B Ifi27l2b 232.7 195.2 295.9 324.6 279.7 284.4 0.814448070214921 0.167620977538959 -0.296105380460445 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) -- -- -- -- -- -- IPR009311 [Interferon alpha-inducible protein 6/27] -- -- Q9CZP5 Mitochondrial chaperone BCS1 Bcs1l 224.8 219.4 279.4 288 279.7 304.5 0.829626232515478 0.0730832647535536 -0.269466582460365 Nonsignificant None 2 Molecular Function:ATP binding (GO:0005524),Biological Process:mitochondrial respiratory chain complex III assembly (GO:0034551) mitochondrial chaperone BCS1 -- -- AAA+-type ATPase O Posttranslational modification, protein turnover, chaperones ; IPR003959 [ATPase, AAA-type, core] ; IPR014851[BCS1, N-terminal] -- -- O88653 Ragulator complex protein LAMTOR3 Lamtor3 326.7 330.6 280.2 274.2 282.1 319.2 1.07081667618504 0.387251173795407 0.098711511837048 Nonsignificant None 1 Biological Process:regulation of TOR signaling (GO:0032006) ragulator complex protein LAMTOR3 -- ko04010 MAPK signaling pathway ko04150 mTOR signaling pathway -- -- -- IPR015019 [Ragulator complex protein LAMTOR3] -- -- Q91X21 Uncharacterized protein KIAA2013 Kiaa2013 233.7 207.1 212.4 238.9 224.3 223.4 0.951354500436936 0.308716536984444 -0.0719450663955617 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR018795 [Protein of unknown function DUF2152] -- -- G3X9C2 F-box only protein 50 Nccrp1 202.7 172.1 179.1 217.4 266.1 237.6 0.768132020524199 0.0299341212816766 -0.380573803489405 Nonsignificant None -- -- -- -- -- -- -- -- IPR007397 [F-box associated (FBA) domain] -- -- P28825 Meprin A subunit alpha Mep1a 173.7 180.3 224.5 230.4 214 238.7 0.846874542526717 0.1174526315802 -0.239779832862926 Nonsignificant None 4 Molecular Function:metalloendopeptidase activity (GO:0004222),Molecular Function:protein binding (GO:0005515),Biological Process:proteolysis (GO:0006508),Cellular Component:membrane (GO:0016020) meprin A 3.4.24.18 ko04974 Protein digestion and absorption Meprin A metalloprotease O Posttranslational modification, protein turnover, chaperones ; IPR000742 [EGF-like domain] ; IPR000998[MAM domain] ; IPR001506[Peptidase M12A] -- -- Q6ZWY3 40S ribosomal protein S27-like Rps27l 2150.3 2196.7 1996.4 1933.5 2220.2 1974.4 1.03513323868736 0.542983870379236 0.0498164782771189 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S27e -- ko03010 Ribosome 40s ribosomal protein S27 J Translation, ribosomal structure and biogenesis ; IPR000592 [Ribosomal protein S27e] -- -- O35127 Protein C10 Grcc10 278.2 257.3 327.8 278.6 364.7 314.7 0.901148225469729 0.387209136055398 -0.150163667470017 Nonsignificant None -- -- -- -- -- -- -- -- IPR026317 [Protein C10] -- -- Q921W0 Charged multivesicular body protein 1a Chmp1a 1045 990.4 1165.5 1250.9 1268 1258.8 0.847314503533896 0.0641035225230323 -0.239030530913434 Nonsignificant None 1 Biological Process:vacuolar transport (GO:0007034) charged multivesicular body protein 1 -- ko04144 Endocytosis ko04217 Necroptosis Vacuolar assembly/sorting protein DID2 U Intracellular trafficking, secretion, and vesicular transport ; IPR005024 [Snf7 family] -- -- H3BJM1 Forkhead box protein P1 Foxp1 132.4 117.2 128.6 97.1 98.1 114.5 1.2211817888279 0.0346455965020529 0.288277980275098 Nonsignificant None 1 Molecular Function:sequence-specific DNA binding (GO:0043565) forkhead box protein P -- -- Predicted forkhead transcription factor K Transcription ; IPR001766 [Fork head domain] ; IPR032354[FOXP, coiled-coil domain] -- Fork head Q8BTW3 Exosome complex component MTR3 Exosc6 152.7 145.1 146.7 160.4 160.6 153.8 0.936183656276327 0.0348271673463215 -0.0951365159247746 Nonsignificant None -- -- exosome complex component MTR3 -- ko03018 RNA degradation Exosomal 3'-5' exoribonuclease complex, subunit Rrp41 and related exoribonucleases J Translation, ribosomal structure and biogenesis ; IPR001247 [Exoribonuclease, phosphorolytic domain 1] -- -- Q3TNL3 Pannexin_like domain-containing protein (Fragment) Lrrc8c 45.2 37.5 34.3 43.1 35.5 45.9 0.939759036144578 0.606976199774936 -0.0896372124846764 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) volume-regulated anion channel -- -- FOG: Leucine rich repeat R General function prediction only ; IPR001611 [Leucine-rich repeat] ; IPR021040[LRRC8, pannexin-like TM region] -- -- P28076 Proteasome subunit beta type-9 Psmb9 1229.7 1340.4 1472.1 1343.9 1526.7 1375.2 0.952046728531726 0.492631755203534 -0.0708957089943502 Nonsignificant None 3 Molecular Function:threonine-type endopeptidase activity (GO:0004298),Cellular Component:proteasome core complex (GO:0005839),Biological Process:proteolysis involved in cellular protein catabolic process (GO:0051603) 20S proteasome subunit beta 9 3.4.25.1 ko03050 Proteasome 20S proteasome, regulatory subunit beta type PSMB6/PSMB9/PRE3 O Posttranslational modification, protein turnover, chaperones ; IPR001353 [Proteasome, subunit alpha/beta] -- -- Q80WT5 Aftiphilin Aftph 141.9 155.2 161 171 152.5 165.9 0.936044135676338 0.257062710009548 -0.095351538561382 Nonsignificant None -- -- -- -- -- -- -- -- IPR029205 [Aftiphilin, clathrin-binding box] -- -- Q3UHE0 E3 ubiquitin-protein ligase Ubr2 433.2 439.9 417.1 363.1 360.3 396.4 1.15217003036256 0.0133584024283857 0.204353636797486 Nonsignificant None 2 Molecular Function:zinc ion binding (GO:0008270),Biological Process:protein catabolic process (GO:0030163) E3 ubiquitin-protein ligase UBR2 2.3.2.27 -- N-end rule pathway, recognition component UBR1 O Posttranslational modification, protein turnover, chaperones ; IPR003126 [Zinc finger, UBR-type] ; IPR003769[Adaptor protein ClpS, core] -- -- O88845 A-kinase anchor protein 10, mitochondrial Akap10 203.1 194.1 198.4 201.1 199.5 224.7 0.952502798656645 0.311382254174191 -0.0702047633290343 Nonsignificant None -- -- A-kinase anchor protein 10 -- -- Protein kinase A anchoring protein T Signal transduction mechanisms ; IPR016137 [RGS domain] -- -- Q9D1B9 39S ribosomal protein L28, mitochondrial Mrpl28 859.2 838.8 965.2 890.4 947.8 893.9 0.974781303759013 0.624371798691051 -0.0368495143562924 Nonsignificant None 1 Molecular Function:structural constituent of ribosome (GO:0003735) large subunit ribosomal protein L28 -- ko03010 Ribosome Uncharacterized conserved protein (melanoma antigen P15) S Function unknown ; IPR026569 [Ribosomal protein L28/L24] -- -- E9Q9C7 Actin-binding LIM protein 1 Ablim1 233.8 229.5 281.6 296.3 332.5 286.1 0.814187342879003 0.0603833539541163 -0.29656730095504 Nonsignificant None 3 Molecular Function:actin binding (GO:0003779),Biological Process:cytoskeleton organization (GO:0007010),Molecular Function:zinc ion binding (GO:0008270) actin-binding LIM protein -- ko04360 Axon guidance Actin-binding LIM Zn-finger protein Limatin involved in axon guidance TZ Signal transduction mechanisms ; Cytoskeleton ; IPR001781 [Zinc finger, LIM-type] ; IPR003128[Villin headpiece] ; IPR032402[Putative adherens-junction anchoring domain] -- -- O35490 Betaine--homocysteine S-methyltransferase 1 Bhmt 241.4 273.2 284.6 254 283.9 233.9 1.0355014252397 0.663019417688194 0.050329539251164 Nonsignificant None -- -- betaine-homocysteine S-methyltransferase 2.1.1.5 ko00260 Glycine, serine and threonine metabolism ko00270 Cysteine and methionine metabolism ko01100 Metabolic pathways Homocysteine S-methyltransferase E Amino acid transport and metabolism ; IPR003726 [Homocysteine-binding domain] -- -- Q3U7R4 RNA helicase Ddx24 473.3 448.6 407.2 376.9 347.4 393.9 1.18860668932212 0.0407236548190151 0.249271405381991 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase DDX24/MAK5 3.6.4.13 -- RNA helicase A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR011545[DEAD/DEAH box helicase domain] -- -- P53702 Holocytochrome c-type synthase Hccs 163.4 267.5 295.9 310 323.5 262.1 0.811523001339884 0.273595307831431 -0.301296108618482 Nonsignificant None 2 Molecular Function:holocytochrome-c synthase activity (GO:0004408),Cellular Component:mitochondrion (GO:0005739) cytochrome c heme-lyase 4.4.1.17 ko00860 Porphyrin and chlorophyll metabolism Holocytochrome c synthase/heme-lyase CO Energy production and conversion ; Posttranslational modification, protein turnover, chaperones ; IPR000511 [Cytochrome c/c1 haem-lyase] -- -- Q3TRM4 Patatin-like phospholipase domain-containing protein 6 Pnpla6 323.2 298.2 321.2 337.7 325.1 301.5 0.97749662967956 0.615439576569887 -0.0328363667415075 Nonsignificant None 1 Biological Process:lipid metabolic process (GO:0006629) lysophospholipid hydrolase 3.1.1.5 ko00564 Glycerophospholipid metabolism Predicted esterase of the alpha-beta hydrolase superfamily (Neuropathy target esterase), contains cAMP-binding domains R General function prediction only ; IPR000595 [Cyclic nucleotide-binding domain] ; IPR002641[Patatin/Phospholipase A2-related] -- -- P85094 Isochorismatase domain-containing protein 2A Isoc2a 350.8 389.8 436.9 518.8 473.6 547.1 0.764858720363755 0.0212848316070922 -0.386734807544671 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) -- -- -- Mitochondrial associated endoribonuclease MAR1 (isochorismatase superfamily) R General function prediction only ; IPR000868 [Isochorismatase-like] -- -- P70232 Neural cell adhesion molecule L1-like protein Chl1 69.1 66.3 77.2 78.2 69.9 84.8 0.912838127951911 0.279145184782264 -0.131569042679762 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) L1 cell adhesion molecule like protein -- -- Neural cell adhesion molecule L1 T Signal transduction mechanisms ; IPR003961 [Fibronectin type III] ; IPR007110[Immunoglobulin-like domain] ; IPR013098[Immunoglobulin I-set] ; IPR026966[Neurofascin/L1/NrCAM, C-terminal domain] -- -- Q9QXD6 Fructose-1,6-bisphosphatase 1 Fbp1 92.2 91 102.2 116 114.8 123.8 0.804850535815003 0.00704823261993071 -0.313207201422925 Nonsignificant None -- -- fructose-1,6-bisphosphatase I 3.1.3.11 ko00010 Glycolysis / Gluconeogenesis ko00030 Pentose phosphate pathway ko00051 Fructose and mannose metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko04152 AMPK signaling pathway ko04910 Insulin signaling pathway Fructose-1,6-bisphosphatase G Carbohydrate transport and metabolism ; IPR033391 [Fructose-1-6-bisphosphatase class I, N-terminal] -- -- Q6ZPU9 KIF-binding protein Kifbp 259.3 225.7 221.2 292.7 246.4 261.7 0.881868131868132 0.157589448632344 -0.181365153076393 Nonsignificant None -- -- -- -- -- -- -- -- IPR022083 [KIF-1 binding protein] -- -- A0A0R4J1E8 Deoxyribonuclease TATDN1 Tatdn1 195.2 169 156.9 183.8 171.9 190 0.954920285871358 0.547295844161492 -0.0665477889410937 Nonsignificant None -- -- TatD DNase family protein 3.1.21.- -- TatD-related DNase L Replication, recombination and repair ; IPR001130 [TatD family] -- -- Q64434 Protein-tyrosine kinase 6 Ptk6 571.1 519.9 436.9 349.3 404.6 380.1 1.3473544973545 0.0359452857946572 0.430129482789099 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein binding (GO:0005515),Biological Process:protein phosphorylation (GO:0006468) protein tyrosine kinase 6 2.7.10.2 -- Tyrosine kinases T Signal transduction mechanisms ; IPR000980 [SH2 domain] ; IPR001245[Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR001452[SH3 domain] -- -- Q9EPL9 Peroxisomal acyl-coenzyme A oxidase 3 Acox3 364.7 367.3 442.4 397.9 457.6 427.1 0.915640106034617 0.306050760880808 -0.127147438994581 Nonsignificant None 5 Molecular Function:acyl-CoA dehydrogenase activity (GO:0003995),Molecular Function:acyl-CoA oxidase activity (GO:0003997),Cellular Component:peroxisome (GO:0005777),Biological Process:fatty acid beta-oxidation (GO:0006635),Biological Process:oxidation-reduction process (GO:0055114) acyl-CoA oxidase 1.3.3.6 ko00071 Fatty acid degradation ko00592 alpha-Linolenic acid metabolism ko01040 Biosynthesis of unsaturated fatty acids ko01100 Metabolic pathways ko01212 Fatty acid metabolism ko03320 PPAR signaling pathway ko04024 cAMP signaling pathway ko04146 Peroxisome Pristanoyl-CoA/acyl-CoA oxidase IQ Lipid transport and metabolism ; Secondary metabolites biosynthesis, transport and catabolism ; IPR002655 [Acyl-CoA oxidase, C-terminal] ; IPR006091[Acyl-CoA oxidase/dehydrogenase, central domain] ; IPR009075[Acyl-CoA dehydrogenase/oxidase C-terminal] -- -- Q3UWC2 Serum amyloid A protein Saa1 1557.8 1544.9 1639.7 1863.9 2373.6 1876.4 0.775675100999362 0.055116335631762 -0.36647560269324 Nonsignificant None 1 Cellular Component:extracellular region (GO:0005576) serum amyloid A protein -- -- -- -- -- IPR000096 [Serum amyloid A protein] -- -- Q3TJZ7 Uncharacterized protein Jpt2 559.1 676.4 653.4 665.1 736.2 569.8 0.958297397392319 0.67208982563876 -0.0614546443955793 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q3TQK8 Squalene monooxygenase Sqle 288.1 330.5 293.7 306.3 299.9 308.5 0.997376188914398 0.955740148843616 -0.00379033397895039 Nonsignificant None 4 Molecular Function:squalene monooxygenase activity (GO:0004506),Cellular Component:integral component of membrane (GO:0016021),Molecular Function:flavin adenine dinucleotide binding (GO:0050660),Biological Process:oxidation-reduction process (GO:0055114) squalene monooxygenase 1.14.14.17 ko00100 Steroid biosynthesis ko01100 Metabolic pathways Squalene monooxygenase I Lipid transport and metabolism ; IPR013698 [Squalene epoxidase] -- -- Q6P9P6 Kinesin-like protein KIF11 Kif11 244.1 249.3 205.2 203.7 223.2 212.4 1.09275770373846 0.258360937135581 0.127973548891005 Nonsignificant None 4 Molecular Function:microtubule motor activity (GO:0003777),Molecular Function:ATP binding (GO:0005524),Biological Process:microtubule-based movement (GO:0007018),Molecular Function:microtubule binding (GO:0008017) kinesin family member 11 -- -- Kinesin-like protein Z Cytoskeleton ; IPR001752 [Kinesin motor domain] ; IPR025901[Kinesin-associated microtubule-binding domain] -- -- Q91YE7 RNA-binding protein 5 Rbm5 172.9 172.9 181.3 177.1 191.9 174.8 0.969290180213314 0.409263559697875 -0.0449994592952278 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:zinc ion binding (GO:0008270) RNA-binding protein 5/10 -- -- RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains R General function prediction only ; IPR000467 [G-patch domain] ; IPR000504[RNA recognition motif domain] ; IPR001876[Zinc finger, RanBP2-type] -- -- Q922H1 Protein arginine N-methyltransferase 3 Prmt3 305.7 283.7 289.6 276.8 338.9 287.6 0.973098638326137 0.709627380086003 -0.0393420434150674 Nonsignificant None -- -- type I protein arginine methyltransferase 2.1.1.319 -- Protein arginine N-methyltransferase PRMT1 and related enzymes OKT Posttranslational modification, protein turnover, chaperones ; Transcription ; Signal transduction mechanisms ; -- -- -- P62254 Ubiquitin-conjugating enzyme E2 G1 Ube2g1 85.4 87.4 73.9 81 99.7 75.3 0.963671875 0.733361431667727 -0.0533860945872392 Nonsignificant None -- -- ubiquitin-conjugating enzyme E2 G1 2.3.2.23 ko04120 Ubiquitin mediated proteolysis ko04141 Protein processing in endoplasmic reticulum ko05012 Parkinson's disease Ubiquitin-protein ligase O Posttranslational modification, protein turnover, chaperones ; IPR000608 [Ubiquitin-conjugating enzyme E2] -- -- Q3U4T5 PUM-HD domain-containing protein (Fragment) Pum1 459.7 504.9 547.6 546.7 600.8 521.9 0.905834431532287 0.202870261606458 -0.142680716399327 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) pumilio RNA-binding family -- -- Translational repressor Pumilio/PUF3 and related RNA-binding proteins (Puf superfamily) J Translation, ribosomal structure and biogenesis ; IPR001313 [Pumilio RNA-binding repeat] -- -- E9QKV6 Unconventional myosin-IXb Myo9b 524.8 508.6 814.9 889.2 908.6 775.2 0.718344345122425 0.0886581698636032 -0.477252515585325 Nonsignificant None 5 Molecular Function:motor activity (GO:0003774),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Biological Process:signal transduction (GO:0007165),Cellular Component:myosin complex (GO:0016459) myosin IX -- -- Myosin VII, myosin IXB and related myosins N Cell motility ; IPR000048 [IQ motif, EF-hand binding site] ; IPR000159[Ras-associating (RA) domain] ; IPR000198[Rho GTPase-activating protein domain] ; IPR001609[Myosin head, motor domain] -- -- Q9D1Q4 Dolichol-phosphate mannosyltransferase subunit 3 Dpm3 389.5 402.3 352 418.9 421.7 382.2 0.935394177298005 0.253118741575698 -0.0963536466836823 Nonsignificant None -- -- dolichyl-phosphate mannosyltransferase polypeptide 3 -- ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways Dolichol-phosphate mannosyltransferase, subunit 3 OT Posttranslational modification, protein turnover, chaperones ; Signal transduction mechanisms ; IPR013174 [Dolichol-phosphate mannosyltransferase subunit 3] -- -- Q3U054 Uncharacterized protein Cdkn2c 294.7 282.5 294 307.3 291.1 324.6 0.943878656554713 0.173807486471674 -0.0833266938162298 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) cyclin-dependent kinase inhibitor 2C -- ko01522 Endocrine resistance ko04110 Cell cycle ko05166 HTLV-I infection ko05202 Transcriptional misregulation in cancer FOG: Ankyrin repeat R General function prediction only ; IPR002110 [Ankyrin repeat] ; IPR020683[Ankyrin repeat-containing domain] -- -- Q91WV0 Protein Dr1 Dr1 255.4 254.9 237.7 239.3 220.4 238.1 1.0719403840642 0.11835299539406 0.100224672580625 Nonsignificant None -- -- down-regulator of transcription 1 -- -- Class 2 transcription repressor NC2, beta subunit (Dr1) K Transcription ; IPR003958 [Transcription factor CBF/NF-Y/archaeal histone domain] -- NF-YB Q925N0 Sideroflexin-5 Sfxn5 240.9 227.6 193.2 270.3 269.4 260 0.827435288233087 0.0344085477896851 -0.273281608340104 Nonsignificant None 4 Biological Process:ion transport (GO:0006811),Molecular Function:ion transmembrane transporter activity (GO:0015075),Cellular Component:membrane (GO:0016020),Biological Process:transmembrane transport (GO:0055085) -- -- -- Sideroflexin R General function prediction only ; IPR004686 [Tricarboxylate/iron carrier] -- -- Q8VE80 THO complex subunit 3 Thoc3 442.8 426 536.6 543.4 571 538.4 0.850314617618587 0.0830388211654125 -0.233931355641219 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) THO complex subunit 3 -- ko03013 RNA transport ko03040 Spliceosome WD40 repeat protein S Function unknown ; IPR001680 [WD40 repeat] ; IPR013979[Translation initiation factor, beta propellor-like domain] ; IPR024977[Anaphase-promoting complex subunit 4, WD40 domain] -- -- H3BJU7 Rho guanine nucleotide exchange factor 2 Arhgef2 277.4 305.6 295.1 368 374.1 316.8 0.829256775899518 0.0391022198221377 -0.270109199490955 Nonsignificant None 2 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Biological Process:regulation of Rho protein signal transduction (GO:0035023) Rho guanine nucleotide exchange factor 2 -- ko04530 Tight junction ko05418 Fluid shear stress and atherosclerosis Predicted guanine nucleotide exchange factor T Signal transduction mechanisms ; IPR000219 [Dbl homology (DH) domain] ; IPR001849[Pleckstrin homology domain] -- -- Q9D6V8 Polyadenylate-binding protein-interacting protein 2 Paip2 95.8 93.8 66.2 58.2 62.2 66.4 1.36937901498929 0.0796010810643265 0.453521809171975 Nonsignificant None -- -- -- -- -- -- -- -- IPR009818 [Ataxin-2, C-terminal] -- -- Q9ERI2 Ras-related protein Rab-27A Rab27a 91.3 114.7 85.2 111.5 117.2 93.5 0.903786468032278 0.41903785287335 -0.145946138507873 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-27A -- -- GTPase Rab27, small G protein superfamily U Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- Q8K0M3 Sorbs3 protein Sorbs3 740.3 729.1 542.6 566 576.1 605.1 1.15155677655678 0.247104109591263 0.203585543773037 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Sorbin and SH3 domain-containing protein T Signal transduction mechanisms ; IPR001452 [SH3 domain] ; IPR003127[SoHo domain] -- -- B1AZ39 Chromatin modifying protein 6 Chmp6 500.6 499.1 509.1 486.8 522.4 493.3 1.00419301164725 0.86256783596264 0.00603659018918648 Nonsignificant None 1 Biological Process:vacuolar transport (GO:0007034) charged multivesicular body protein 6 -- ko04144 Endocytosis ko04217 Necroptosis Uncharacterized conserved protein predicted to be involved in protein sorting R General function prediction only ; IPR005024 [Snf7 family] -- -- Q80UW5 Serine/threonine-protein kinase MRCK gamma Cdc42bpg 50.8 61.8 55 55 58.3 62.9 0.951191827468786 0.507111376707426 -0.072191775221062 Nonsignificant None 5 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468),Biological Process:intracellular signal transduction (GO:0035556) serine/threonine-protein kinase MRCK 2.7.11.1 -- Rho-associated, coiled-coil containing protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR001180[Citron homology (CNH) domain] ; IPR002219[Protein kinase C-like, phorbol ester/diacylglycerol-binding domain] ; IPR014930[Myotonic dystrophy protein kinase, coiled coil] ; IPR017892[Protein kinase, C-terminal] -- -- Q8BGT6 MICAL-like protein 1 Micall1 169.3 149.8 138.5 153.7 142.6 153 1.018473180503 0.789320493553389 0.0264079902549512 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:zinc ion binding (GO:0008270) MICAL-like protein 1 -- -- -- -- -- IPR001715 [Calponin homology domain] ; IPR001781[Zinc finger, LIM-type] ; IPR022735[Domain of unknown function DUF3585] -- -- B2RUR8 OTU domain-containing protein 7B Otud7b 413.3 400.9 426.1 427.4 416.2 439.8 0.966417328969924 0.222981935161833 -0.0492817708174706 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Molecular Function:zinc ion binding (GO:0008270) OTU domain-containing protein 7 3.4.19.12 -- NF-kappa B regulator AP20/Cezanne T Signal transduction mechanisms ; IPR002653 [Zinc finger, A20-type] ; IPR003323[OTU domain] -- -- Q9ES46 Beta-parvin Parvb 61.4 67.5 73.1 85.5 89.4 68.4 0.830250719276613 0.131611010703601 -0.268381027299272 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) parvin -- ko04510 Focal adhesion Alpha-parvin and related focal adhesion proteins Z Cytoskeleton ; IPR001715 [Calponin homology domain] -- -- A2NVE9 Immnuoglobulin kappa light chain (Fragment) 831.7 827 702.8 454.3 541.9 543.4 1.53383995843076 0.00599246943767229 0.617147959227089 Significant up -- -- pre-B lymphocyte gene -- -- -- -- -- IPR013106 [Immunoglobulin V-set domain] -- -- Q71RI9 Kynurenine--oxoglutarate transaminase 3 Kyat3 451 445.1 503.1 560.3 508 564.7 0.856827924066136 0.0396287003484862 -0.222922596527405 Nonsignificant None 2 Biological Process:biosynthetic process (GO:0009058),Molecular Function:pyridoxal phosphate binding (GO:0030170) -- -- ko00380 Tryptophan metabolism ko00450 Selenocompound metabolism ko01100 Metabolic pathways ko05204 Chemical carcinogenesis Kynurenine aminotransferase, glutamine transaminase K E Amino acid transport and metabolism ; IPR004839 [Aminotransferase, class I/classII] -- -- Q61087 Laminin subunit beta-3 Lamb3 372.2 378.2 364 313.2 324.8 310.3 1.17515554149531 0.000789642612970713 0.232851721975598 Nonsignificant None -- -- laminin, beta 3 -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko05145 Toxoplasmosis ko05146 Amoebiasis ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05222 Small cell lung cancer Extracellular matrix glycoprotein Laminin subunit beta W Extracellular structures ; IPR002049 [Laminin EGF domain] ; IPR008211[Laminin, N-terminal] -- -- Q8BI72 CDKN2A-interacting protein Cdkn2aip 157.8 163.3 191 190.1 220.4 183.8 0.861686017163049 0.14720037930852 -0.214765821861748 Nonsignificant None -- -- -- -- -- -- -- -- IPR021859 [XRN-Two Binding Domain, XTBD] -- -- D3YTR5 Methyl-CpG-binding domain protein 3 Mbd3 626.7 635.6 683.9 558.7 562.5 554.6 1.16135577037833 0.03490144777181 0.215809995920146 Nonsignificant None -- -- methyl-CpG-binding domain protein 3 -- -- Methyl-CpG binding transcription regulators KB Transcription ; Chromatin structure and dynamics ; IPR025884 [Methyl-CpG binding protein 2/3, C-terminal domain] ; IPR032343[Methyl-CpG-binding domain protein 2/3, p55-binding region] -- MBD Q3TYX3 Histone-lysine N-trimethyltransferase SMYD5 Smyd5 613.9 595.4 694.9 606.5 597.8 583.9 1.06486970137569 0.28369429189539 0.0906769115032673 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Predicted histone tail methylase containing SET domain B Chromatin structure and dynamics ; IPR001214 [SET domain] -- -- P53569 CCAAT/enhancer-binding protein zeta Cebpz 148.3 164.8 155.5 164.2 163 178.6 0.926453143534994 0.147762560016887 -0.110210082800103 Nonsignificant None -- -- ribosome biogenesis protein MAK21 -- -- CAATT-binding transcription factor/60S ribosomal subunit biogenesis protein JK Translation, ribosomal structure and biogenesis ; Transcription ; IPR005612 [CCAAT-binding factor] -- -- D6RFU9 Synaptophysin-like protein Sypl 734.4 720.4 1340.2 1464.8 1334.4 1623.9 0.631909746557844 0.0698421775959905 -0.662209576819743 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q9D8X2 Coiled-coil domain-containing protein 124 Ccdc124 612.7 625.2 596.8 558.9 513.9 529.8 1.14482715587171 0.00758474152893577 0.195129799029756 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR010422 [Coiled-coil domain-containing protein 124] -- -- Q3UQM8 Ubiquinone biosynthesis O-methyltransferase, mitochondrial Coq3 554.5 520.3 477 502.3 460.4 503.9 1.0580935497068 0.34523580295359 0.0814671867445708 Nonsignificant None -- -- -- -- ko00130 Ubiquinone and other terpenoid-quinone biosynthesis ko01100 Metabolic pathways Methyltransferases H Coenzyme transport and metabolism ; -- -- -- Q3TGS9 ADP-ribosylation factor GTPase-activating protein 1 Arfgap1 631.1 598.3 593.2 600 613.8 596.9 1.0065720439609 0.774841998435761 0.00945043479818803 Nonsignificant None 1 Molecular Function:GTPase activator activity (GO:0005096) ADP-ribosylation factor GTPase-activating protein 1 -- ko04144 Endocytosis ADP-ribosylation factor GTPase activator TUZ Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; Cytoskeleton ; IPR001164 [Arf GTPase activating protein] -- -- Q9D2Y4 Mixed lineage kinase domain-like protein Mlkl 722.1 736.7 751.5 740.4 797.1 719 0.979525814314203 0.568226756571462 -0.0298445812690863 Nonsignificant None 2 Molecular Function:protein kinase activity (GO:0004672),Biological Process:protein phosphorylation (GO:0006468) mixed lineage kinase domain-like 2.7.11.1 ko04217 Necroptosis ko04668 TNF signaling pathway -- -- -- IPR001245 [Serine-threonine/tyrosine-protein kinase catalytic domain] -- -- Q99L27 GMP reductase 2 Gmpr2 469.7 426.8 391 403.4 417.3 435.3 1.02507961783439 0.690916368814298 0.035735968066316 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:oxidation-reduction process (GO:0055114) GMP reductase 1.7.1.7 ko00230 Purine metabolism IMP dehydrogenase/GMP reductase F Nucleotide transport and metabolism ; IPR001093 [IMP dehydrogenase/GMP reductase] -- -- Q8BHG9 CGG triplet repeat-binding protein 1 Cggbp1 605.8 612.7 610 551.8 568 588.6 1.07029969562163 0.0209371016278111 0.0980148235865887 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q80T21 ADAMTS-like protein 4 Adamtsl4 109.6 123.5 122 112.8 106.7 114.5 1.06317365269461 0.232331462687569 0.088377257659557 Nonsignificant None 3 Molecular Function:metalloendopeptidase activity (GO:0004222),Molecular Function:peptidase activity (GO:0008233),Cellular Component:extracellular matrix (GO:0031012) -- -- -- Serine proteinase inhibitor (KU family) with thrombospondin repeats O Posttranslational modification, protein turnover, chaperones ; IPR000884 [Thrombospondin type-1 (TSP1) repeat] ; IPR010294[ADAM-TS Spacer 1] ; IPR010909[PLAC] -- -- Q8CIE4 Protein mono-ADP-ribosyltransferase PARP10 Parp10 102.1 164.7 169.5 161 170 153.6 0.900330169211721 0.508876194694549 -0.151473931074847 Nonsignificant None 1 Molecular Function:NAD+ ADP-ribosyltransferase activity (GO:0003950) poly [ADP-ribose] polymerase 10/14/15 2.4.2.30 -- -- -- -- IPR012317 [Poly(ADP-ribose) polymerase, catalytic domain] -- -- Q9QXE7 F-box-like/WD repeat-containing protein TBL1X Tbl1x 512.3 543.7 559.7 524.9 543.4 567.9 0.987470969319154 0.733016762316242 -0.0181897599101935 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) transducin (beta)-like 1 -- ko04310 Wnt signaling pathway Beta-transducin family (WD-40 repeat) protein B Chromatin structure and dynamics ; IPR001680 [WD40 repeat] ; IPR006594[LIS1 homology motif] -- -- Q8R2E9 ERO1-like protein beta Ero1b 40.4 43.8 34.6 45.4 65.1 39.9 0.789893617021277 0.263706539276749 -0.340269730876872 Nonsignificant None 3 Molecular Function:protein disulfide isomerase activity (GO:0003756),Cellular Component:endoplasmic reticulum (GO:0005783),Biological Process:oxidation-reduction process (GO:0055114) ERO1-like protein beta 1.8.4.- ko04141 Protein processing in endoplasmic reticulum Endoplasmic reticulum membrane-associated oxidoreductin involved in disulfide bond formation OU Posttranslational modification, protein turnover, chaperones ; Intracellular trafficking, secretion, and vesicular transport ; IPR007266 [Endoplasmic reticulum oxidoreductin 1] -- -- E9QLB2 Palmitoyl-protein hydrolase Lyplal1 400.5 388.1 494.3 595.5 544.1 568.3 0.751156390889396 0.0180887950462161 -0.412814786520083 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) phospholipase/carboxylesterase -- -- Lysophospholipase I Lipid transport and metabolism ; IPR003140 [Phospholipase/carboxylesterase/thioesterase] -- -- Q8CEW1 Uncharacterized protein Hmgn1 145 165.7 190.1 189.7 202 153.3 0.918899082568807 0.493775881617144 -0.122021667619033 Nonsignificant None 3 Cellular Component:chromatin (GO:0000785),Cellular Component:nucleus (GO:0005634),Molecular Function:nucleosomal DNA binding (GO:0031492) high-mobility group nucleosome-binding domain-containing protein 1 -- ko05168 Herpes simplex infection -- -- -- IPR000079 [High mobility group protein HMGN] -- -- Q9CQ40 39S ribosomal protein L49, mitochondrial Mrpl49 238.6 237.3 284.6 247.1 271.2 265.7 0.970025510204082 0.672057076325118 -0.0439054063907115 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L49 -- -- Uncharacterized conserved protein NOF (Neighbor of FAU) S Function unknown ; IPR007740 [Ribosomal protein L49/IMG2] -- -- D3Z3F8 Spastic paraplegia 20, spartin (Troyer syndrome) homolog (human) Spg20 239.4 250.4 324.8 330.3 300.1 341.1 0.838497169325785 0.150878799152703 -0.254122181469292 Nonsignificant None -- -- spartin -- ko04144 Endocytosis Uncharacterized conserved protein S Function unknown ; IPR009686 [Senescence/spartin-associated] -- -- Q99M51 Cytoplasmic protein NCK1 Nck1 367.7 379.6 405.8 451.2 448.6 432.9 0.86523598709387 0.00901769838671961 -0.208834423436123 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) NCK adaptor protein 1 -- ko04012 ErbB signaling pathway ko04360 Axon guidance ko04660 T cell receptor signaling pathway Adaptor protein NCK/Dock, contains SH2 and SH3 domains T Signal transduction mechanisms ; IPR000980 [SH2 domain] ; IPR001452[SH3 domain] -- -- F8WHX2 Copper homeostasis protein cutC homolog Cutc 169.5 161 189.9 233 215.3 220.5 0.77811004784689 0.00793427222166291 -0.361953885363087 Nonsignificant None 2 Molecular Function:copper ion binding (GO:0005507),Biological Process:copper ion homeostasis (GO:0055070) copper homeostasis protein -- -- Predicted Cu2+ homeostasis protein CutC P Inorganic ion transport and metabolism ; IPR005627 [Copper homeostasis protein CutC] -- -- P52432 DNA-directed RNA polymerases I and III subunit RPAC1 Polr1c 384.9 359 397 516.8 455.2 532.3 0.758425845908396 0.00969643016396849 -0.39891996513364 Nonsignificant None 2 Molecular Function:DNA-directed 5'-3' RNA polymerase activity (GO:0003899),Molecular Function:protein dimerization activity (GO:0046983) DNA-directed RNA polymerases I and III subunit RPAC1 -- ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways ko03020 RNA polymerase ko04623 Cytosolic DNA-sensing pathway ko05169 Epstein-Barr virus infection RNA polymerase I and III, subunit RPA40/RPC40 K Transcription ; IPR011262 [DNA-directed RNA polymerase, insert domain] ; IPR011263[DNA-directed RNA polymerase, RpoA/D/Rpb3-type] -- -- Q8BJL1 F-box only protein 30 Fbxo30 101.2 102 107.4 99.9 114.3 119.5 0.930776146239137 0.280574457286517 -0.103493856795018 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:zinc ion binding (GO:0008270) F-box protein 30 -- -- -- -- -- IPR001293 [Zinc finger, TRAF-type] ; IPR001810[F-box domain] -- -- Q9JHP7 Protein O-glucosyltransferase 2 Poglut2 1124.4 1141.9 1158.4 1041.5 1185.9 1114.8 1.02468433965651 0.555742902210387 0.0351795470481931 Nonsignificant None -- -- -- -- -- Endoplasmic reticulum protein EP58, contains filamin rod domain and KDEL motif R General function prediction only ; IPR006598 [Lipopolysaccharide-modifying protein] ; IPR017868[Filamin/ABP280 repeat-like] -- -- A2AI52 Ubiquitin carboxyl-terminal hydrolase 8 Usp8 700.6 694.9 595.9 557.3 571.3 560.6 1.17890125503197 0.0952971213497997 0.237442882998154 Nonsignificant None 2 Biological Process:protein deubiquitination (GO:0016579),Molecular Function:thiol-dependent ubiquitinyl hydrolase activity (GO:0036459) ubiquitin carboxyl-terminal hydrolase 8 3.4.19.12 ko04137 Mitophagy - animal ko04144 Endocytosis Ubiquitin C-terminal hydrolase O Posttranslational modification, protein turnover, chaperones ; IPR001394 [Peptidase C19, ubiquitin carboxyl-terminal hydrolase] ; IPR001763[Rhodanese-like domain] ; IPR015063[USP8 dimerisation domain] -- -- Q9D1C3 Protein preY, mitochondrial Pyurf 80.9 78.1 92.6 103.2 101.9 102.1 0.819010416666667 0.0518172745599872 -0.288046293841867 Nonsignificant None -- -- -- -- -- -- -- -- IPR005651 [Uncharacterised protein family UPF0434/Trm112] -- -- Q61176 Arginase-1 Arg1 582.7 706.9 505.5 482.2 426.3 428.1 1.34303456531498 0.067736071006453 0.425496435492675 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) arginase 3.5.3.1 ko00220 Arginine biosynthesis ko00330 Arginine and proline metabolism ko01100 Metabolic pathways ko01230 Biosynthesis of amino acids ko05146 Amoebiasis Arginase E Amino acid transport and metabolism ; IPR006035 [Ureohydrolase] -- -- P63254 Cysteine-rich protein 1 Crip1 1551.7 1370.5 1480.1 2723.6 2848.7 2859.7 0.52209440227704 0.000039703966594645 -0.93761740421617 Significant down 1 Molecular Function:zinc ion binding (GO:0008270) -- -- -- Regulatory protein MLP and related LIM proteins TZ Signal transduction mechanisms ; Cytoskeleton ; IPR001781 [Zinc finger, LIM-type] -- -- B7ZN75 Trim47 protein Trim47 256.8 261.7 246.2 249.7 255.6 253.2 1.00817402768622 0.693970679738515 0.0117446936089624 Nonsignificant None 2 Cellular Component:intracellular (GO:0005622),Molecular Function:zinc ion binding (GO:0008270) tripartite motif-containing protein 47 -- -- -- -- -- IPR000315 [B-box-type zinc finger] ; IPR006574[SPRY-associated] -- -- Q921I9 Exosome complex component RRP41 Exosc4 219.2 222.4 268.2 265 269 275.1 0.877271041898406 0.108912312158273 -0.188905447895815 Nonsignificant None -- -- exosome complex component RRP41 -- ko03018 RNA degradation Exosomal 3'-5' exoribonuclease complex, subunit Rrp41 and related exoribonucleases J Translation, ribosomal structure and biogenesis ; IPR001247 [Exoribonuclease, phosphorolytic domain 1] ; IPR015847[Exoribonuclease, phosphorolytic domain 2] -- -- A0A0G2JDV3 Guanylate-binding protein 6 Gbp6 307.3 335.8 300 290.4 291.1 276.7 1.0989279888138 0.0759003144069908 0.136096851632878 Nonsignificant None 2 Molecular Function:GTPase activity (GO:0003924),Molecular Function:GTP binding (GO:0005525) guanylate-binding protein 6 -- -- Guanylate-binding protein R General function prediction only ; IPR003191 [Guanylate-binding protein, C-terminal] ; IPR015894[Guanylate-binding protein, N-terminal] -- -- Q80TS8 Protein sel-1 homolog 3 Sel1l3 567.2 522.4 506.6 548.1 572.8 549.4 0.95563671196791 0.281192620891301 -0.06546581711165 Nonsignificant None -- -- -- -- -- Extracellular protein SEL-1 and related proteins MOT Cell wall/membrane/envelope biogenesis ; Posttranslational modification, protein turnover, chaperones ; Signal transduction mechanisms ; IPR006597 [Sel1-like repeat] -- -- Q8BNV1 tRNA (uracil-5-)-methyltransferase homolog A Trmt2a 676.3 762.8 756.1 702 708.6 710.9 1.03473957105821 0.470162523064706 0.049267707994714 Nonsignificant None 2 Biological Process:RNA processing (GO:0006396),Molecular Function:RNA methyltransferase activity (GO:0008173) tRNA (uracil-5-)-methyltransferase 2.1.1.- -- tRNA uracil-5-methyltransferase and related tRNA-modifying enzymes J Translation, ribosomal structure and biogenesis ; IPR010280 [(Uracil-5)-methyltransferase family] -- -- G5E8A7 Protein Smaug homolog 2 Samd4b 45.1 40.8 36.3 52.5 43.2 47.5 0.853351955307263 0.131311609847788 -0.228787207445527 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Predicted RNA-binding protein involved in translational regulation JT Translation, ribosomal structure and biogenesis ; Signal transduction mechanisms ; IPR001660 [Sterile alpha motif domain] -- -- Q9ES00 Ubiquitin conjugation factor E4 B Ube4b 520.9 492.5 464.9 559.7 562.7 532.2 0.893448567629638 0.0356429913767004 -0.16254341359078 Nonsignificant None 5 Cellular Component:ubiquitin ligase complex (GO:0000151),Molecular Function:ubiquitin-protein transferase activity (GO:0004842),Biological Process:ubiquitin-dependent protein catabolic process (GO:0006511),Biological Process:protein ubiquitination (GO:0016567),Molecular Function:ubiquitin-ubiquitin ligase activity (GO:0034450) ubiquitin conjugation factor E4 B 2.3.2.27 ko04120 Ubiquitin mediated proteolysis ko04141 Protein processing in endoplasmic reticulum Ubiquitin fusion degradation protein-2 O Posttranslational modification, protein turnover, chaperones ; IPR003613 [U box domain] ; IPR019474[Ubiquitin conjugation factor E4, core] -- -- E9PYG6 RAS p21 protein activator 1 Rasa1 739.7 778.8 740.2 661.9 720.9 690.5 1.08942265952829 0.044650278760831 0.123563780046741 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Biological Process:regulation of GTPase activity (GO:0043087) Ras GTPase-activating protein 1 -- ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04360 Axon guidance GTPase-activating protein R General function prediction only ; IPR000008 [C2 domain] ; IPR000980[SH2 domain] ; IPR001452[SH3 domain] ; IPR001849[Pleckstrin homology domain] ; IPR001936[Ras GTPase-activating protein] -- -- Q99LR1 Lysophosphatidylserine lipase ABHD12 Abhd12 466.8 435 427.2 392 395.6 387.1 1.13135268579212 0.0141272058895703 0.178048742524939 Nonsignificant None -- -- abhydrolase domain-containing protein 12 3.1.1.23 -- Predicted alpha/beta hydrolase R General function prediction only ; IPR022742 [Serine aminopeptidase, S33] -- -- P04627 Serine/threonine-protein kinase A-Raf Araf 532.6 607.4 636.9 693 679 659 0.874889217134416 0.0600187740154214 -0.192827747667361 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Biological Process:protein phosphorylation (GO:0006468),Biological Process:signal transduction (GO:0007165),Biological Process:intracellular signal transduction (GO:0035556) A-Raf proto-oncogene serine/threonine-protein kinase 2.7.11.1 ko01521 EGFR tyrosine kinase inhibitor resistance ko01522 Endocrine resistance ko04010 MAPK signaling pathway ko04012 ErbB signaling pathway ko04068 FoxO signaling pathway ko04270 Vascular smooth muscle contraction ko04650 Natural killer cell mediated cytotoxicity ko04720 Long-term potentiation ko04726 Serotonergic synapse ko04730 Long-term depression ko04810 Regulation of actin cytoskeleton ko04910 Insulin signaling pathway ko04914 Progesterone-mediated oocyte maturation ko05034 Alcoholism ko05160 Hepatitis C ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05210 Colorectal cancer ko05211 Renal cell carcinoma ko05212 Pancreatic cancer ko05213 Endometrial cancer ko05214 Glioma ko05215 Prostate cancer ko05218 Melanoma ko05219 Bladder cancer ko05220 Chronic myeloid leukemia ko05221 Acute myeloid leukemia ko05223 Non-small cell lung cancer ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer Serine/threonine protein kinase RAF T Signal transduction mechanisms ; IPR001245 [Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR002219[Protein kinase C-like, phorbol ester/diacylglycerol-binding domain] ; IPR003116[Raf-like Ras-binding] -- -- Q5SW15 U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase Mettl16 437.8 443.3 414.3 362.7 382.2 409.2 1.12243306472576 0.0434016236024638 0.16662941372589 Nonsignificant None 1 Molecular Function:methyltransferase activity (GO:0008168) methyltransferase 2.1.1.- -- Predicted DNA methylase S Function unknown ; IPR010286 [Ribosomal RNA large subunit methyltransferase F-like] -- -- Q9DD18 D-aminoacyl-tRNA deacylase 1 Dtd1 279.8 303.7 350.3 392 369.1 362.8 0.830856837796957 0.0481386878039119 -0.267328182504754 Nonsignificant None 2 Cellular Component:cytoplasm (GO:0005737),Biological Process:D-amino acid catabolic process (GO:0019478) D-tyrosyl-tRNA(Tyr) deacylase 3.1.-.- -- D-Tyr-tRNA (Tyr) deacylase J Translation, ribosomal structure and biogenesis ; IPR003732 [D-aminoacyl-tRNA deacylase DTD] -- -- Q8N7N5 DDB1- and CUL4-associated factor 8 Dcaf8 652.2 643.9 660.5 654.7 633.3 656 1.00648148148148 0.657442979327086 0.00932062797647835 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) WD repeat-containing protein 42A -- -- WD40 repeat protein R General function prediction only ; IPR001680 [WD40 repeat] -- -- Q91Z96 BMP-2-inducible protein kinase Bmp2k 130.8 120.4 120.1 147.8 153.3 143 0.83607295654132 0.00622567535283854 -0.258299256112372 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) BMP2 inducible kinase 2.7.11.1 ko05202 Transcriptional misregulation in cancer ARK protein kinase family T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR028182[BMP-2-inducible protein kinase, C-terminal] -- -- Q9CXP8 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 Gng10 42.6 39.6 50.8 61.7 55.9 75.7 0.688049663735127 0.0410660018133903 -0.539415391822684 Nonsignificant None 3 Molecular Function:signal transducer activity (GO:0004871),Cellular Component:heterotrimeric G-protein complex (GO:0005834),Biological Process:G-protein coupled receptor signaling pathway (GO:0007186) guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 -- ko04014 Ras signaling pathway ko04062 Chemokine signaling pathway ko04151 PI3K-Akt signaling pathway ko04371 Apelin signaling pathway ko04713 Circadian entrainment ko04723 Retrograde endocannabinoid signaling ko04724 Glutamatergic synapse ko04725 Cholinergic synapse ko04726 Serotonergic synapse ko04727 GABAergic synapse ko04728 Dopaminergic synapse ko04926 Relaxin signaling pathway ko05032 Morphine addiction ko05034 Alcoholism ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05200 Pathways in cancer G protein gamma subunit T Signal transduction mechanisms ; IPR015898 [G-protein gamma-like domain] -- -- J3QK17 Solute carrier family 2, facilitated glucose transporter member 4 Slc2a4 236 244.9 285.5 311.4 317.8 284.1 0.839154713675682 0.0563907978754658 -0.252991272213386 Nonsignificant None 3 Cellular Component:integral component of membrane (GO:0016021),Molecular Function:transmembrane transporter activity (GO:0022857),Biological Process:transmembrane transport (GO:0055085) MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 4 -- ko04068 FoxO signaling pathway ko04152 AMPK signaling pathway ko04910 Insulin signaling pathway ko04920 Adipocytokine signaling pathway ko04930 Type II diabetes mellitus ko04931 Insulin resistance Permease of the major facilitator superfamily G Carbohydrate transport and metabolism ; IPR005828 [Major facilitator, sugar transporter-like] -- -- Q9CQ80 Vacuolar protein-sorting-associated protein 25 Vps25 763.6 767.2 877.3 862.5 906.8 807.9 0.934386155517616 0.296731979441551 -0.0979091964336096 Nonsignificant None -- -- ESCRT-II complex subunit VPS25 -- ko04144 Endocytosis Uncharacterized conserved protein S Function unknown ; IPR008570 [ESCRT-II complex, vps25 subunit] -- -- Q3TYE1 Casein kinase I isoform epsilon Csnk1e 315.3 288.3 261 315.5 339.7 330.8 0.876876267748479 0.0782188206964857 -0.18955481036937 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) casein kinase 1, epsilon 2.7.11.1 ko04068 FoxO signaling pathway ko04310 Wnt signaling pathway ko04340 Hedgehog signaling pathway ko04390 Hippo signaling pathway ko04392 Hippo signaling pathway - multiple species ko04710 Circadian rhythm Casein kinase (serine/threonine/tyrosine protein kinase) T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q8BLG5 CAP10 domain-containing protein Poglut1 577.3 542.6 574 521.6 576.5 540.1 1.03400073251129 0.396120141051524 0.0482372076935005 Nonsignificant None -- -- protein glucosyltransferase 2.4.1.- ko00514 Other types of O-glycan biosynthesis Endoplasmic reticulum protein EP58, contains filamin rod domain and KDEL motif R General function prediction only ; IPR006598 [Lipopolysaccharide-modifying protein] -- -- Q9D187 Cytosolic iron-sulfur assembly component 2B Ciao2b 71.5 59.5 56.6 69.4 68.6 63.2 0.932405566600398 0.412355739763326 -0.100970477290151 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR002744 [Domain of unknown function DUF59] -- -- Q3U0M1 Trafficking protein particle complex subunit 9 Trappc9 131.7 128.7 194.5 210.6 213.6 225.1 0.700600646850454 0.0416067505082027 -0.513335774735522 Nonsignificant None -- -- trafficking protein particle complex subunit 9 -- -- Targeting complex (TRAPP) subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR013935 [TRAPP II complex, Trs120] -- -- A0A1L1SQR4 Dedicator of cytokinesis protein 6 Dock6 90.8 93.1 86.3 99.7 122.9 111.5 0.808739898234062 0.0381152177293429 -0.306252308009286 Nonsignificant None -- -- dedicator of cytokinesis protein 6/7/8 -- -- PH domain-containing protein T Signal transduction mechanisms ; IPR010703 [Dedicator of cytokinesis, C-terminal] ; IPR021816[Dedicator of cytokinesis C/D, N-terminal] ; IPR027007[DHR-1 domain] -- -- A0A0A6YVS2 Calcium load-activated calcium channel (Fragment) Tmco1 410 428.5 559.9 557.9 577.6 543.3 0.832975935191804 0.12462480656662 -0.263653278385311 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) calcium load-activated calcium channel -- -- Predicted membrane protein S Function unknown ; IPR002809 [Integral membrane protein EMC3/TMCO1-like] -- -- Q3UWV9 Calponin-homology (CH) domain-containing protein Hook2 325.6 333.4 353.1 322.6 356.6 340.1 0.992936328853134 0.860174832642328 -0.0102268856865077 Nonsignificant None -- -- protein HOOK2 -- -- -- -- -- IPR008636 [Hook-related protein family] -- -- Q8R3Y8 Interferon regulatory factor 2-binding protein 1 Irf2bp1 302.2 318 316 327.5 350.9 325.7 0.932377253261627 0.0761140576099697 -0.101014286695732 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR018957 [Zinc finger, C3HC4 RING-type] ; IPR022750[Interferon regulatory factor 2-binding protein 1 & 2, zinc finger] -- -- Q99ME2 WD repeat-containing protein 6 Wdr6 66.8 64.6 68.1 62.9 64.8 71.2 1.00301659125189 0.9447217997552 0.00434547027596418 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- WD-repeat protein WDR6, WD repeat superfamily R General function prediction only ; IPR001680 [WD40 repeat] -- -- Q9JJF9 Signal peptide peptidase-like 2A Sppl2a 228.6 310.1 333 274.2 302.5 246.3 1.0591737545565 0.671996782922459 0.0829392789191167 Nonsignificant None 2 Molecular Function:aspartic-type endopeptidase activity (GO:0004190),Cellular Component:integral component of membrane (GO:0016021) signal peptide peptidase-like 2A 3.4.23.- -- Uncharacterized conserved protein, contains PA domain R General function prediction only ; IPR003137 [PA domain] ; IPR007369[Peptidase A22B, signal peptide peptidase] -- -- Q3UKC1 Tax1-binding protein 1 homolog Tax1bp1 528.1 519.4 555.8 462 511 515.3 1.077269367735 0.132210637439897 0.107379036238094 Nonsignificant None -- -- Tax1-binding protein 1 -- ko04137 Mitophagy - animal -- -- -- IPR012852 [Calcium binding and coiled-coil domain-like] -- -- Q69ZQ2 Pre-mRNA-splicing factor ISY1 homolog Isy1 353.2 329.5 306.9 300.2 298.1 299 1.10286414799955 0.147696157858603 0.141255089135861 Nonsignificant None -- -- pre-mRNA-splicing factor ISY1 -- ko03040 Spliceosome mRNA splicing factor A RNA processing and modification ; IPR009360 [Isy1-like splicing] -- -- Q9JM08 Histone deacetylase Hdac3 32.7 26.6 24.5 38.5 24.5 31.3 0.888653234358431 0.500516110677286 -0.170307526975745 Nonsignificant None -- -- histone deacetylase 3 3.5.1.98 ko04919 Thyroid hormone signaling pathway ko05034 Alcoholism ko05165 Human papillomavirus infection ko05203 Viral carcinogenesis Histone deacetylase complex, catalytic component RPD3 B Chromatin structure and dynamics ; IPR023801 [Histone deacetylase domain] -- -- Q8R4R6 Nucleoporin NUP35 Nup35 370 369.7 363.8 395 446.8 406.2 0.884214743589744 0.0898762482734281 -0.177531304582634 Nonsignificant None -- -- nuclear pore complex protein Nup53 -- ko03013 RNA transport Mitotic phosphoprotein D Cell cycle control, cell division, chromosome partitioning ; IPR007846 [RNA-recognition motif (RRM) Nup35-type domain] -- -- Q3UDY2 acidPPc domain-containing protein Sgpp1 122.2 111.8 109.4 113.6 105.6 107.3 1.05176110260337 0.289775440242698 0.072807047568341 Nonsignificant None -- -- sphingosine-1-phosphate phosphatase 1 3.1.3.- ko00600 Sphingolipid metabolism ko04071 Sphingolipid signaling pathway Sphingoid base-phosphate phosphatase I Lipid transport and metabolism ; IPR000326 [Phosphatidic acid phosphatase type 2/haloperoxidase] -- -- B1AYU7 Pre-mRNA-splicing factor CWC22 homolog Cwc22 1073.4 1006.5 928.9 832.2 859.1 930.1 1.1477836270695 0.0643559240848254 0.198850699874933 Nonsignificant None 2 Molecular Function:RNA binding (GO:0003723),Molecular Function:protein binding (GO:0005515) pre-mRNA-splicing factor CWC22 -- -- Uncharacterized conserved protein R General function prediction only ; IPR003890 [MIF4G-like, type 3] ; IPR003891[Initiation factor eIF-4 gamma, MA3] -- -- Q52L66 Ubiquitin-like 7 (Bone marrow stromal cell-derived) Ubl7 22.6 18 26.1 28.7 20.6 20.9 0.95014245014245 0.758258466914462 -0.0737842691199756 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Ubiquitin-like protein OR Posttranslational modification, protein turnover, chaperones ; General function prediction only ; IPR000626 [Ubiquitin domain] ; IPR015940[Ubiquitin-associated domain] -- -- E9Q137 Testis-expressed protein 264 homolog Tex264 961.3 982.1 1050.1 927.3 976.5 956.4 1.04660513250822 0.217410255486536 0.065717238999333 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- P58064 28S ribosomal protein S6, mitochondrial Mrps6 1849.5 1853.3 2113.1 1770.9 1820.5 1808.6 1.07701851851852 0.192347264419966 0.107043056145021 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412),Molecular Function:rRNA binding (GO:0019843) small subunit ribosomal protein S6 -- ko03010 Ribosome Mitochondrial ribosomal protein MRP17 J Translation, ribosomal structure and biogenesis ; IPR000529 [Ribosomal protein S6] -- -- Q8C8K1 Receptor protein-tyrosine kinase Ephb4 190.1 170.4 175.8 214.5 201.1 203.2 0.866677440206852 0.018796474288091 -0.206432943425436 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein binding (GO:0005515),Biological Process:protein phosphorylation (GO:0006468) Eph receptor B4 2.7.10.1 ko04360 Axon guidance Tyrosine kinase, EPH (ephrin) receptor family T Signal transduction mechanisms ; IPR001090 [Ephrin receptor ligand binding domain] ; IPR001245[Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR001660[Sterile alpha motif domain] ; IPR003961[Fibronectin type III] ; IPR011641[Tyrosine-protein kinase ephrin type A/B receptor-like] ; IPR027936[Ephrin receptor, transmembrane domain] -- -- Q7YQ01 MHC class II antigen A beta (Fragment) H2-Ab1 630.9 618 808.9 807.8 787.9 807.2 0.856381871904782 0.201620050001306 -0.22367383815259 Nonsignificant None 4 Biological Process:immune response (GO:0006955),Cellular Component:membrane (GO:0016020),Biological Process:antigen processing and presentation (GO:0019882),Cellular Component:MHC class II protein complex (GO:0042613) major histocompatibility complex, class II -- ko04145 Phagosome ko04514 Cell adhesion molecules (CAMs) ko04612 Antigen processing and presentation ko04640 Hematopoietic cell lineage ko04658 Th1 and Th2 cell differentiation ko04659 Th17 cell differentiation ko04672 Intestinal immune network for IgA production ko04940 Type I diabetes mellitus ko05140 Leishmaniasis ko05145 Toxoplasmosis ko05150 Staphylococcus aureus infection ko05152 Tuberculosis ko05164 Influenza A ko05166 HTLV-I infection ko05168 Herpes simplex infection ko05310 Asthma ko05320 Autoimmune thyroid disease ko05321 Inflammatory bowel disease (IBD) ko05322 Systemic lupus erythematosus ko05323 Rheumatoid arthritis ko05330 Allograft rejection ko05332 Graft-versus-host disease ko05416 Viral myocarditis -- -- -- IPR000353 [MHC class II, beta chain, N-terminal] ; IPR003597[Immunoglobulin C1-set] -- -- Q9CQE3 28S ribosomal protein S17, mitochondrial Mrps17 340.3 341.6 410.8 389.5 357.7 358 0.988689829895042 0.878433913205847 -0.0164101027769787 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S17 -- ko03010 Ribosome Mitochondrial/chloroplast ribosomal S17-like protein J Translation, ribosomal structure and biogenesis ; IPR000266 [Ribosomal protein S17/S11] -- -- Q8BVL3 Sorting nexin-17 Snx17 477.4 441.7 461 533.7 517.6 595.4 0.838100443310864 0.026370864493311 -0.254804938811527 Nonsignificant None 1 Molecular Function:phosphatidylinositol binding (GO:0035091) sorting nexin-17 -- -- Sorting nexin protein SNX27 RTU General function prediction only ; Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR001683 [Phox homologous domain] -- -- Q3TGF2 Protein FAM107B Fam107b 560.2 665.6 561.3 382.4 424.3 410.8 1.46784394250513 0.00687631904076118 0.553698592607656 Nonsignificant None -- -- -- -- -- -- -- -- IPR009533 [Protein of unknown function DUF1151] -- -- A0A087WRY3 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 Nucks1 891.4 902.4 769 833 911 819.5 0.99972693582992 0.996594684360432 -0.000394002120398411 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q7TPH6 E3 ubiquitin-protein ligase MYCBP2 Mycbp2 185.4 173.4 150 174.8 176.3 176.7 0.964001515725654 0.604496244642828 -0.0528926800419131 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:zinc ion binding (GO:0008270) E3 ubiquitin-protein ligase MYCBP2 2.3.2.27 -- Inhibitor of type V adenylyl cyclases/Neuronal presynaptic protein Highwire/PAM/RPM-1 T Signal transduction mechanisms ; IPR000408 [Regulator of chromosome condensation, RCC1] ; IPR001841[Zinc finger, RING-type] ; IPR003646[SH3-like domain, bacterial-type] ; IPR004939[APC10/DOC domain] ; IPR012983[PHR] ; IPR017868[Filamin/ABP280 repeat-like] -- -- D3YWY5 Mth938 domain-containing protein (Fragment) Aamdc 498 518.1 718.5 587.6 560.5 570.1 1.00954487254103 0.945355851763845 0.0137050374189292 Nonsignificant None -- -- -- -- -- -- -- -- IPR007523 [NDUFAF3/Mth938 domain-containing protein] -- -- O54782 Epididymis-specific alpha-mannosidase Man2b2 203.3 186.9 196.4 268.3 225.6 254.3 0.784014969259556 0.0160108680131246 -0.351046894793871 Nonsignificant None 5 Molecular Function:alpha-mannosidase activity (GO:0004559),Biological Process:carbohydrate metabolic process (GO:0005975),Biological Process:mannose metabolic process (GO:0006013),Molecular Function:zinc ion binding (GO:0008270),Molecular Function:mannosidase activity (GO:0015923) epididymis-specific alpha-mannosidase 3.2.1.24 ko00511 Other glycan degradation Glycosyl hydrolase, family 38 - alpha-mannosidase G Carbohydrate transport and metabolism ; IPR000602 [Glycoside hydrolase family 38, N-terminal domain] ; IPR011682[Glycosyl hydrolase family 38, C-terminal] ; IPR015341[Glycoside hydrolase family 38, central domain] -- -- Q4VC42 Aim1 protein (Fragment) Crybg1 453.3 434 321.2 300.8 311.9 330 1.28195608358969 0.102922584673173 0.358346839903148 Nonsignificant None -- -- -- -- -- -- -- -- IPR000772 [Ricin B, lectin domain] ; IPR001064[Beta/gamma crystallin] -- -- O88630 Golgi SNAP receptor complex member 1 Gosr1 607.3 630.8 694.3 672.5 655.4 648.8 0.977588910810948 0.612589749834847 -0.0327001747151622 Nonsignificant None -- -- golgi SNAP receptor complex member 1 -- ko04130 SNARE interactions in vesicular transport SNARE protein GS28 U Intracellular trafficking, secretion, and vesicular transport ; -- -- -- Q8K1H1 Tudor domain-containing protein 7 Tdrd7 397 400.3 492.1 500.5 477.5 465.7 0.893121839717393 0.191900417579373 -0.163071093599397 Nonsignificant None -- -- tudor domain-containing protein 1/4/6/7 -- -- Transcriptional coactivator p100 K Transcription ; IPR002999 [Tudor domain] ; IPR025605[OST-HTH/LOTUS domain] -- -- Q8CGA0 Protein phosphatase 1F Ppm1f 416.7 439.7 417.4 420.9 420.1 427.6 1.00409900677913 0.837439802462426 0.00590152979366369 Nonsignificant None 1 Molecular Function:catalytic activity (GO:0003824) protein phosphatase 1F 3.1.3.16 -- Serine/threonine protein phosphatase T Signal transduction mechanisms ; IPR001932 [PPM-type phosphatase domain] -- -- O88593 Peptidoglycan recognition protein 1 Pglyrp1 986.8 1228.2 1065.8 542 661.9 598.8 1.81993676152438 0.00337513277799401 0.863888321072196 Significant up 2 Molecular Function:N-acetylmuramoyl-L-alanine amidase activity (GO:0008745),Biological Process:peptidoglycan catabolic process (GO:0009253) peptidoglycan recognition protein -- -- -- -- -- IPR002502 [N-acetylmuramoyl-L-alanine amidase domain] -- -- Q8C112 Uncharacterized protein (Fragment) P3h4 298.2 321.1 394 382.8 383.1 296.3 0.953963472039164 0.710245303825228 -0.0679940694499456 Nonsignificant None -- -- Membrane-associated proteoglycan Leprecan S Function unknown ; -- -- -- Q9D4I9 Ras-related protein Rab-23 Rab23 621.4 614.4 721.8 695.9 697.4 704.1 0.933346047487365 0.311101252831022 -0.0995160208487314 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-23 -- -- GTP-binding protein T Signal transduction mechanisms ; IPR001806 [Small GTPase superfamily] -- -- Q8BG60 Thioredoxin-interacting protein Txnip 877.6 830 797.3 714.6 749.6 755.6 1.12843499414362 0.0232877311133105 0.174323311460292 Nonsignificant None -- -- thioredoxin-interacting protein -- ko04621 NOD-like receptor signaling pathway Thioredoxin binding protein TBP-2/VDUP1 R General function prediction only ; IPR011021 [Arrestin-like, N-terminal] ; IPR011022[Arrestin C-terminal-like domain] -- -- Q3TZB3 Carbonic anhydrase Car12 362.9 342.3 338.5 349.1 344.8 299.2 1.05095156580405 0.393938092675067 0.0716961827306967 Nonsignificant None -- -- carbonic anhydrase 4.2.1.1 ko00910 Nitrogen metabolism Carbonic anhydrase R General function prediction only ; IPR001148 [Alpha carbonic anhydrase] -- -- E9QKK8 Phospholipid-transporting ATPase Atp11c 136.7 125.5 120.3 133.3 138.2 144.8 0.918808551525342 0.12759969099766 -0.122163810672842 Nonsignificant None 2 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:metal ion binding (GO:0046872) phospholipid-translocating ATPase 3.6.3.1 -- P-type ATPase R General function prediction only ; IPR008250 [P-type ATPase, A domain] ; IPR032630[P-type ATPase, C-terminal] ; IPR032631[P-type ATPase, N-terminal] -- -- B8JJ89 Apoptotic chromatin condensation inducer in the nucleus (Fragment) Acin1 139.7 128.6 160.5 187.4 184.9 209.7 0.736769759450172 0.0139663083632191 -0.440714247337874 Nonsignificant None -- -- apoptotic chromatin condensation inducer in the nucleus -- ko03013 RNA transport ko03015 mRNA surveillance pathway ko03040 Spliceosome Acinus (induces apoptotic chromatin condensation) B Chromatin structure and dynamics ; -- -- -- Q3UWA6 Guanylyl cyclase C Gucy2c 347.2 330 327.8 299.6 302.5 311.1 1.10052562417871 0.0121791976600982 0.138192736728951 Nonsignificant None 5 Molecular Function:protein kinase activity (GO:0004672),Biological Process:protein phosphorylation (GO:0006468),Biological Process:cyclic nucleotide biosynthetic process (GO:0009190),Molecular Function:phosphorus-oxygen lyase activity (GO:0016849),Biological Process:intracellular signal transduction (GO:0035556) heat-stable enterotoxin receptor 4.6.1.2 ko00230 Purine metabolism Natriuretic peptide receptor, guanylate cyclase T Signal transduction mechanisms ; IPR001054 [Adenylyl cyclase class-3/4/guanylyl cyclase] ; IPR001245[Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR001828[Receptor, ligand binding region] -- -- Q9D0A3 Arpin Arpin 1271.9 1316.3 1411.1 1144.4 1145.4 1188.3 1.14985193065179 0.0162467576899118 0.201448093632345 Nonsignificant None -- -- -- -- -- -- -- -- IPR018889 [Uncharacterised protein family UPF0552] -- -- Q6P1G0 HEAT repeat-containing protein 6 Heatr6 270.8 243.1 253 218.4 238.8 213.7 1.14309136980176 0.0458409175306829 0.192940725942122 Nonsignificant None -- -- -- -- -- HEAT and armadillo repeat-containing protein R General function prediction only ; IPR025283 [Domain of unknown function DUF4042] -- -- A2A513 Keratin, type I cytoskeletal 10 Krt10 567.2 205.6 133.5 815.9 149.2 154.3 0.809630159013757 0.797369987364358 -0.304665062946555 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) type I keratin, acidic -- -- -- -- -- IPR001664 [Intermediate filament protein] -- -- Q9Z266 SNARE-associated protein Snapin Snapin 101.6 106.6 94.8 129.8 129.9 123.8 0.790091264667536 0.00249899568409187 -0.339908784029983 Nonsignificant None -- -- SNARE-associated protein Snapin -- -- -- -- -- IPR028119 [Snapin/Pallidin/Snn1] -- -- Q80WW9 DDRGK domain-containing protein 1 Ddrgk1 35.9 37.6 24.2 29.7 27.8 34 1.06775956284153 0.67610899472245 0.0945868187969803 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019153 [DDRGK domain containing protein] -- -- Q059U9 A kinase (PRKA) anchor protein 8 Akap8 871.9 842.1 871.8 773.4 789.9 785.1 1.10109010390053 0.00202011386030707 0.138932531692082 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634) A-kinase anchor protein 8 -- -- -- -- -- IPR007071 [A-kinase anchoring protein 95 (AKAP95)] -- -- A0A1D5RME6 Pleckstrin homology domain-containing family A member 6 (Fragment) Plekha6 100.9 90.5 87.1 92.6 76.4 86.7 1.08916699256942 0.293883109075776 0.123225166985745 Nonsignificant None -- -- -- -- -- -- -- -- IPR001849 [Pleckstrin homology domain] -- -- Q5HZY7 V-type proton ATPase subunit G Atp6v1g1 587.1 584.5 600.1 539.5 597.3 568.3 1.0390592927101 0.270335019010784 0.0552779823057682 Nonsignificant None -- -- V-type H+-transporting ATPase subunit G -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04145 Phagosome ko04150 mTOR signaling pathway ko04721 Synaptic vesicle cycle ko04966 Collecting duct acid secretion ko05323 Rheumatoid arthritis Vacuolar H+-ATPase V1 sector, subunit G C Energy production and conversion ; -- -- -- Q8VDT9 39S ribosomal protein L50, mitochondrial Mrpl50 317.3 333.4 359.1 338.5 347 337.6 0.987000293226469 0.7414394701565 -0.0188775815974734 Nonsignificant None 1 Cellular Component:mitochondrion (GO:0005739) large subunit ribosomal protein L50 -- -- -- -- -- IPR018305 [Ribosomal protein L50, mitochondria] -- -- F6R7Y0 CMP-sialic acid transporter (Fragment) Slc35a1 601.3 619.6 717.7 975.9 965.1 976.2 0.664541341011929 0.0114239617449559 -0.589569142763365 Significant down 4 Cellular Component:Golgi membrane (GO:0000139),Molecular Function:sugar:proton symporter activity (GO:0005351),Biological Process:carbohydrate transport (GO:0008643),Cellular Component:integral component of membrane (GO:0016021) solute carrier family 35 (UDP-sugar transporter), member A1/2/3 -- -- Predicted UDP-galactose transporter G Carbohydrate transport and metabolism ; IPR007271 [Nucleotide-sugar transporter] -- -- A0A1W2P6P0 Protein PALS1 Pals1 61.4 50.6 58.2 60.2 69.9 60.5 0.892969569779643 0.206631701954729 -0.163317082223979 Nonsignificant None -- -- MAGUK p55 subfamily member 5 -- ko04390 Hippo signaling pathway ko04530 Tight junction ko05165 Human papillomavirus infection Calcium/calmodulin-dependent serine protein kinase/membrane-associated guanylate kinase T Signal transduction mechanisms ; IPR014775 [L27 domain, C-terminal] ; IPR015145[L27-N] -- -- Q8R4Z6 RNA helicase Ddx20 113.4 118.5 107.2 101.8 87.4 102.6 1.16209732693626 0.0562400485873189 0.21673090110754 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase DDX20 3.6.4.13 ko03013 RNA transport DEAD box protein K Transcription ; IPR001650 [Helicase, C-terminal] ; IPR011545[DEAD/DEAH box helicase domain] -- -- A0A494BB76 Leucine zipper putative tumor suppressor 2 Lzts2 80.2 79.5 89.3 87.1 75.1 85.7 1.00443727309399 0.94429416785602 0.0063874708687213 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q8C6S5 FAD-binding FR-type domain-containing protein Cybb 869.3 1454.9 1243 725.6 729 684.2 1.66785113147559 0.107588425173477 0.737990522915286 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) NADPH oxidase 2 1.-.-.- ko04066 HIF-1 signaling pathway ko04145 Phagosome ko04216 Ferroptosis ko04217 Necroptosis ko04621 NOD-like receptor signaling pathway ko04670 Leukocyte transendothelial migration ko04933 AGE-RAGE signaling pathway in diabetic complications ko05140 Leishmaniasis Ferric reductase, NADH/NADPH oxidase and related proteins PQ Inorganic ion transport and metabolism ; Secondary metabolites biosynthesis, transport and catabolism ; IPR013112 [FAD-binding 8] ; IPR013121[Ferric reductase, NAD binding domain] ; IPR013130[Ferric reductase transmembrane component-like domain] -- -- A0A494B9D7 N-alpha-acetyltransferase 40 Naa40 245.1 228 199.5 187.5 199.5 177.5 1.19149689991143 0.0708852938490545 0.25277519786622 Nonsignificant None 1 Molecular Function:N-acetyltransferase activity (GO:0008080) N-alpha-acetyltransferase 40 2.3.1.257 -- Acetyltransferase (GNAT) domain-containing protein R General function prediction only ; IPR000182 [GNAT domain] -- -- B2RXL7 Kidins220 protein Kidins220 249.5 227.6 220.4 262.6 248 261.6 0.903263403263403 0.0663545556822652 -0.146781337337946 Nonsignificant None -- -- ankyrin repeat-rich membrane spanning protein -- ko04722 Neurotrophin signaling pathway Integral membrane ankyrin-repeat protein Kidins220 (protein kinase D substrate) R General function prediction only ; IPR011646 [KAP family P-loop domain] ; IPR020683[Ankyrin repeat-containing domain] -- -- Q64310 Surfeit locus protein 4 Surf4 500.8 569.7 570.9 586.4 554.2 537.7 0.978013466007269 0.674854450167484 -0.0320737654888286 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) ER-derived vesicles protein -- -- Putative cargo transport protein ERV29 U Intracellular trafficking, secretion, and vesicular transport ; IPR002995 [Surfeit locus 4] -- -- A1A553 Non-specific serine/threonine protein kinase Stk10 437.1 454.5 419 457.5 495.5 434.6 0.944508503891611 0.278862634616785 -0.0823643088962415 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) serine/threonine kinase 10 2.7.11.1 ko04914 Progesterone-mediated oocyte maturation Ste20-like serine/threonine protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR022165[Polo kinase kinase] -- -- Q9D706 RNA polymerase II-associated protein 3 Rpap3 260.6 275.1 266.2 258.9 273.8 279.4 0.987439970446989 0.671104067397912 -0.0182350499718854 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Uncharacterized conserved protein, contains LRR repeats S Function unknown ; IPR001440 [Tetratricopeptide repeat 1] ; IPR019734[Tetratricopeptide repeat] ; IPR025986[RNA-polymerase II-associated protein 3-like, C-terminal domain] -- -- Q99JP0 Mitogen-activated protein kinase kinase kinase kinase 3 Map4k3 605.7 841.7 763.8 660.4 723.7 579.6 1.12603758211539 0.365955523462321 0.171254978951617 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) mitogen-activated protein kinase kinase kinase kinase 3 2.7.11.1 ko04010 MAPK signaling pathway Mitogen-activated protein kinase kinase kinase kinase (MAP4K), germinal center kinase family T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR001180[Citron homology (CNH) domain] -- -- Q80XK6 Autophagy-related protein 2 homolog B Atg2b 583.8 588.8 506.4 499.9 502.9 527.2 1.09738562091503 0.151191237351872 0.134070577357016 Nonsignificant None -- -- autophagy-related protein 2 -- ko04136 Autophagy - other ko04140 Autophagy - animal Cytoplasm to vacuole targeting protein U Intracellular trafficking, secretion, and vesicular transport ; IPR015412 [Autophagy-related, C-terminal] ; IPR026854[Vacuolar protein sorting-associated protein 13, N-terminal domain] ; IPR026885[Autophagy-related protein 2 CAD motif] -- -- Q5QGU0 Receptor expression-enhancing protein Reep5 1193.4 1293.4 1689.5 1615 1635.8 1564.4 0.867315999335438 0.294071038597187 -0.205370371781551 Nonsignificant None -- -- receptor expression-enhancing protein 5/6 -- -- Protein involved in membrane traffic (YOP1/TB2/DP1/HVA22 family) U Intracellular trafficking, secretion, and vesicular transport ; IPR004345 [TB2/DP1/HVA22-related protein] -- -- Q6ZPR5 Sphingomyelin phosphodiesterase 4 Smpd4 205.5 218.6 231.9 209.6 225.2 223.1 0.997112023103815 0.947589198265951 -0.00417249788930363 Nonsignificant None 1 Molecular Function:sphingomyelin phosphodiesterase D activity (GO:0050290) sphingomyelin phosphodiesterase 4 3.1.4.12 ko00600 Sphingolipid metabolism ko01100 Metabolic pathways Predicted membrane-anchored protein S Function unknown ; IPR024129 [Sphingomyelin phosphodiesterase 4] -- -- Q8VI84 Nucleolar complex protein 3 homolog Noc3l 923.8 819.9 691.6 627.3 644.2 658.4 1.26187885382662 0.126458678225675 0.3355734116097 Nonsignificant None -- -- nucleolar complex protein 3 -- -- Protein involved in the nuclear export of pre-ribosomes JU Translation, ribosomal structure and biogenesis ; Intracellular trafficking, secretion, and vesicular transport ; IPR005612 [CCAAT-binding factor] ; IPR011501[Nucleolar complex-associated protein 3, N-terminal] -- -- Q7M6W1 Reticulon Rtn1 280.5 300.6 416.8 283.1 286.5 307.4 1.13785632839225 0.403254982199092 0.186318407028296 Nonsignificant None -- -- reticulon-1 -- -- Reticulon U Intracellular trafficking, secretion, and vesicular transport ; IPR003388 [Reticulon] -- -- O70514 Fibroblast growth factor-binding protein 1 Fgfbp1 262.4 227.2 235.2 213.9 248.8 243.3 1.02662889518414 0.701163876642496 0.0379147718876922 Nonsignificant None -- -- -- -- -- -- -- -- IPR010510 [FGF binding 1] -- -- A1A4A7 Pgam5 protein (Fragment) Pgam5 982 1096 916.3 979.2 861.3 782.6 1.14151195150776 0.185983577082667 0.190945964504104 Nonsignificant None -- -- serine/threonine-protein phosphatase PGAM5 3.1.3.16 ko04137 Mitophagy - animal ko04217 Necroptosis ko04668 TNF signaling pathway Predicted phosphoglycerate mutase R General function prediction only ; IPR013078 [Histidine phosphatase superfamily, clade-1] -- -- A4FUS0 Eif2b3 protein Eif2b3 967.8 951.2 949.3 907.7 902.2 931.5 1.04629021667761 0.0169851490716539 0.065283077290561 Nonsignificant None -- -- translation initiation factor eIF-2B subunit gamma -- ko03013 RNA transport Translation initiation factor 2B, gamma subunit (eIF-2Bgamma/GCD1) J Translation, ribosomal structure and biogenesis ; -- -- -- Q9CWW6 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 Pin4 648.4 618 486.3 512.1 543 532.6 1.10392391509731 0.337903232194224 0.142640741776939 Nonsignificant None -- -- peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 5.2.1.8 -- Parvulin-like peptidyl-prolyl cis-trans isomerase O Posttranslational modification, protein turnover, chaperones ; -- -- -- D3Z6P0 Protein disulfide-isomerase A2 Pdia2 273.2 268.4 276.7 278.8 693.3 251.4 0.668818961994279 0.44448052953369 -0.580312344377492 Nonsignificant None 1 Biological Process:cell redox homeostasis (GO:0045454) protein disulfide isomerase family A, member 2 5.3.4.1 -- Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) O Posttranslational modification, protein turnover, chaperones ; IPR013766 [Thioredoxin domain] -- -- Q80WG5 Volume-regulated anion channel subunit LRRC8A Lrrc8a 281.3 277.4 239.3 244.4 238.8 240.6 1.10251450676983 0.204635287994939 0.140797638737169 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) volume-regulated anion channel -- -- FOG: Leucine rich repeat R General function prediction only ; IPR001611 [Leucine-rich repeat] ; IPR021040[LRRC8, pannexin-like TM region] -- -- M4TKR7 Tyrosine-protein kinase receptor Insr 251.2 246.4 319.3 432.9 416 456.7 0.625689338235294 0.00347122185023666 -0.676481574206543 Significant down 7 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:transmembrane receptor protein tyrosine kinase activity (GO:0004714),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468),Biological Process:transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169),Cellular Component:membrane (GO:0016020) insulin receptor 2.7.10.1 ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04022 cGMP-PKG signaling pathway ko04066 HIF-1 signaling pathway ko04068 FoxO signaling pathway ko04072 Phospholipase D signaling pathway ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04152 AMPK signaling pathway ko04211 Longevity regulating pathway ko04213 Longevity regulating pathway - multiple species ko04520 Adherens junction ko04910 Insulin signaling pathway ko04913 Ovarian steroidogenesis ko04923 Regulation of lipolysis in adipocytes ko04930 Type II diabetes mellitus ko04931 Insulin resistance ko04932 Non-alcoholic fatty liver disease (NAFLD) ko04960 Aldosterone-regulated sodium reabsorption Insulin/growth factor receptor (contains protein kinase domain) T Signal transduction mechanisms ; IPR000494 [Receptor L-domain] ; IPR001245[Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR003961[Fibronectin type III] ; IPR006211[Furin-like cysteine-rich domain] -- -- Q8C051 CNH domain-containing protein Vps39 241.5 273 246.2 257.7 273.8 258.4 0.963033295353842 0.431171618914629 -0.0543424170559119 Nonsignificant None -- -- Vam6/Vps39-like protein vacuolar protein sorting-associated protein 39 -- Vacuolar assembly/sorting proteins VPS39/VAM6/VPS3 U Intracellular trafficking, secretion, and vesicular transport ; IPR001180 [Citron homology (CNH) domain] -- -- Q921H9 Cytochrome c oxidase assembly factor 7 Coa7 546.3 593.5 562.7 533.2 481.2 553.7 1.08570881959059 0.155411648616915 0.118637233105747 Nonsignificant None -- -- cytochrome c oxidase assembly factor 7 -- -- Uncharacterized conserved protein (contains TPR repeat) S Function unknown ; IPR006597 [Sel1-like repeat] -- -- Q8CBQ5 Phosphatidylinositol 4-kinase type 2-beta Pi4k2b 206 180.6 163.8 179.9 187.5 176 1.01288185498712 0.863402588456963 0.018465904480123 Nonsignificant None 1 Molecular Function:kinase activity (GO:0016301) phosphatidylinositol 4-kinase type 2 2.7.1.67 ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system Phosphatidylinositol 4-kinase T Signal transduction mechanisms ; IPR000403 [Phosphatidylinositol 3-/4-kinase, catalytic domain] -- -- Q3TRG5 GRAM domain-containing protein Wbp2 452.5 445.2 552.3 559.3 574.1 562 0.85525539695647 0.139203860782664 -0.225572791962274 Nonsignificant None -- -- WW domain binding protein WBP-2, contains GRAM domain T Signal transduction mechanisms ; IPR004182 [GRAM domain] -- -- Q9D939 Sulfotransferase 1C2 Sult1c2 577.6 512.7 630.8 1184.5 934.7 1280.9 0.506190994382518 0.00674219565559181 -0.982246254122396 Significant down 1 Molecular Function:sulfotransferase activity (GO:0008146) sulfotransferase 2.8.2.- -- Sulfotransferase R General function prediction only ; IPR000863 [Sulfotransferase domain] -- -- Q8K301 Probable ATP-dependent RNA helicase DDX52 Ddx52 377.2 348.4 300 254.2 262.6 261.6 1.31757451181912 0.065368579401393 0.397884551837629 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase DDX52/ROK1 3.6.4.13 -- ATP-dependent RNA helicase A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR011545[DEAD/DEAH box helicase domain] -- -- P0DN34 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 Ndufb1 430.9 408.2 544.8 617.3 542.4 604 0.784657254635142 0.0582258868314659 -0.349865485492603 Nonsignificant None 2 Molecular Function:NADH dehydrogenase activity (GO:0003954),Cellular Component:mitochondrion (GO:0005739) -- -- -- -- -- -- IPR012575 [NADH:ubiquinone oxidoreductase, MNLL subunit] -- -- A0A0R4J091 DNA polymerase epsilon subunit 3 Pole3 158.1 157.4 160.7 152.9 138.2 153.6 1.07083427029458 0.109598664838938 0.0987352159188259 Nonsignificant None -- -- DNA polymerase epsilon subunit 3 2.7.7.7 ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways ko03030 DNA replication ko03410 Base excision repair ko03420 Nucleotide excision repair ko05166 HTLV-I infection DNA polymerase epsilon, subunit D K Transcription ; IPR003958 [Transcription factor CBF/NF-Y/archaeal histone domain] -- NF-YB Q8K352 SAM and SH3 domain-containing protein 3 Sash3 127 145.8 103 91.8 109.7 109.5 1.20836012861736 0.190874856631576 0.273050486402091 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Uncharacterized SAM domain protein R General function prediction only ; IPR001660 [Sterile alpha motif domain] ; IPR011511[Variant SH3 domain] ; IPR021090[SAM/SH3 domain-containing] -- -- G5E8T6 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 Magi3 167.8 164.6 142.9 194 162.5 167.1 0.907754010695187 0.269051021697259 -0.139626695642905 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) membrane-associated guanylate kinase-related -- ko04015 Rap1 signaling pathway WW domain-containing protein R General function prediction only ; IPR001202 [WW domain] ; IPR001478[PDZ domain] ; IPR008145[Guanylate kinase/L-type calcium channel beta subunit] -- -- Q8R0F6 Integrin-linked kinase-associated serine/threonine phosphatase 2C Ilkap 488.5 515.7 520.1 569.1 543.9 524.3 0.930983936969401 0.0819911333582243 -0.103171818891163 Nonsignificant None 1 Molecular Function:catalytic activity (GO:0003824) integrin-linked kinase-associated serine/threonine phosphatase 2C 3.1.3.16 -- Serine/threonine protein phosphatase T Signal transduction mechanisms ; IPR001932 [PPM-type phosphatase domain] -- -- Q8BLN5 Lanosterol synthase Lss 532.5 515.9 534.1 566.4 589.2 597.3 0.902789662844429 0.00652683964346686 -0.147538195463129 Nonsignificant None -- -- lanosterol synthase 5.4.99.7 ko00100 Steroid biosynthesis ko01100 Metabolic pathways Oxidosqualene-lanosterol cyclase and related proteins I Lipid transport and metabolism ; IPR032696 [Squalene cyclase, C-terminal] ; IPR032697[Squalene cyclase, N-terminal] -- -- E9PZQ1 DExD/H box helicase 60 Ddx60 168.5 156 132.2 175.2 198.7 191.4 0.807889616133027 0.0464956584628564 -0.307769907277063 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase DDX60 3.6.4.13 -- Predicted helicase, DEAD-box superfamily R General function prediction only ; IPR001650 [Helicase, C-terminal] ; IPR011545[DEAD/DEAH box helicase domain] -- -- Q91VN6 Probable ATP-dependent RNA helicase DDX41 Ddx41 787.1 732 675.1 715.6 658.4 711.5 1.05212179333493 0.385347008630425 0.0733017202859364 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase DDX41 3.6.4.13 -- DEAD-box protein abstrakt A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR011545[DEAD/DEAH box helicase domain] -- -- Q60648 Ganglioside GM2 activator Gm2a 553.9 526.7 692.4 660.4 652.1 605.3 0.924496819272083 0.422684451033653 -0.113259738836352 Nonsignificant None -- -- ganglioside GM2 activator -- ko04142 Lysosome -- -- -- IPR003172 [MD-2-related lipid-recognition domain] -- -- H3BK68 tRNA (guanine(26)-N(2))-dimethyltransferase (Fragment) Trmt1 105.3 87.9 87.6 98.5 101.4 102.2 0.929493545183714 0.299233254326479 -0.10548324842338 Nonsignificant None 3 Molecular Function:RNA binding (GO:0003723),Molecular Function:tRNA (guanine-N2-)-methyltransferase activity (GO:0004809),Biological Process:tRNA processing (GO:0008033) -- -- -- tRNA methyltransferase J Translation, ribosomal structure and biogenesis ; IPR002905 [tRNA methyltransferase, Trm1] -- -- Q8VCY6 U3 small nucleolar RNA-associated protein 6 homolog Utp6 641.6 658.5 669.3 543.4 552.6 559.8 1.18939485445102 0.000365007501928038 0.250227739466361 Nonsignificant None 1 Molecular Function:snoRNA binding (GO:0030515) U3 small nucleolar RNA-associated protein 6 -- ko03008 Ribosome biogenesis in eukaryotes HAT (Half-A-TPR) repeat-containing protein R General function prediction only ; IPR013949 [U3 small nucleolar RNA-associated protein 6] -- -- A0PJ46 Prpf39 protein (Fragment) Prpf39 381.9 363.2 351.7 376.3 404.8 364.7 0.957235119567115 0.3320185350786 -0.0630547666529721 Nonsignificant None -- -- pre-mRNA-processing factor 39 -- -- mRNA processing protein A RNA processing and modification ; -- -- -- Q5ND36 Serine or cysteine peptidase inhibitor clade F member 2 Serpinf2 1500.1 1584.4 1162.5 856 945.2 862.1 1.59463823076634 0.0161699978063168 0.673229162624547 Significant up -- -- alpha-2-antiplasmin -- ko04610 Complement and coagulation cascades Serpin V Defense mechanisms ; IPR023796 [Serpin domain] -- -- Q9D5J6 Sedoheptulokinase Shpk 54.5 47.9 50.6 62.7 71.6 64.1 0.77116935483871 0.0108141831276972 -0.374880372806861 Nonsignificant None 1 Biological Process:carbohydrate metabolic process (GO:0005975) sedoheptulokinase 2.7.1.14 Ribulose kinase and related carbohydrate kinases G Carbohydrate transport and metabolism ; IPR018484 [Carbohydrate kinase, FGGY, N-terminal] -- -- Q80YQ8 E3 ubiquitin-protein ligase RMND5A Rmnd5a 115.1 108.3 205.2 158.3 169.5 155.6 0.886636326023997 0.618937004106554 -0.173585623089035 Nonsignificant None -- -- -- -- -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR024964 [CTLH/CRA C-terminal to LisH motif domain] -- -- D6RHN4 Peroxisomal trans-2-enoyl-CoA reductase Pecr 466.5 461 501.4 525.3 500.3 545.5 0.909490166125644 0.0596911897550614 -0.136870056085329 Nonsignificant None -- -- peroxisomal trans-2-enoyl-CoA reductase 1.3.1.38 ko01040 Biosynthesis of unsaturated fatty acids ko01212 Fatty acid metabolism ko04146 Peroxisome Reductases with broad range of substrate specificities R General function prediction only ; IPR002347 [Short-chain dehydrogenase/reductase SDR] -- -- Q3TJD3 Alkaline phosphatase Alpl 505.7 514.8 397.6 395.9 387.3 424.4 1.17431268631997 0.148554577279496 0.231816608566181 Nonsignificant None 2 Biological Process:metabolic process (GO:0008152),Molecular Function:phosphatase activity (GO:0016791) alkaline phosphatase 3.1.3.1 ko00730 Thiamine metabolism ko00790 Folate biosynthesis ko01100 Metabolic pathways Alkaline phosphatase P Inorganic ion transport and metabolism ; IPR001952 [Alkaline phosphatase] -- -- Q61112 45 kDa calcium-binding protein Sdf4 994.4 1256.6 1368.5 1260.9 1377.8 1149.4 0.955492199255563 0.685537763930155 -0.0656839999590979 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) calcium-binding protein -- -- Calcium binding protein R General function prediction only ; IPR002048 [EF-hand domain] -- -- Q05BE7 Numb protein Numb 415.7 475 413.8 483.2 483 460.3 0.914475990185769 0.131263960031459 -0.128982802764268 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) numb -- ko04330 Notch signaling pathway Adaptor protein NUMB T Signal transduction mechanisms ; IPR006020 [PTB/PI domain] ; IPR010449[NUMB domain] -- -- A2AGS6 Tumor protein p53-inducible protein 11 (Fragment) Trp53i11 475.7 541.9 529.5 524.5 492.6 434.8 1.06556925408086 0.393232883920398 0.091624360621472 Nonsignificant None -- -- -- -- -- -- -- -- IPR028266 [Tumor protein p53-inducible protein 11] -- -- Q0VDM9 Krt78 protein (Fragment) Krt78 523.8 304.4 311.8 1110.7 317 322.6 0.651316917099926 0.497974594970214 -0.618568395621092 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) -- -- -- -- -- -- IPR001664 [Intermediate filament protein] ; IPR032444[Keratin type II head] -- -- Q99JZ0 Syntenin-2 Sdcbp2 362.4 396.3 604.5 487.2 518.9 467.9 0.92483039348711 0.657055501817828 -0.112739283756594 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR001478 [PDZ domain] -- -- Q7TN73 N-acetylneuraminate 9-O-acetyltransferase Casd1 394.5 361.3 382.7 480.3 526.1 529 0.741500586166471 0.00203334369053309 -0.431480261736618 Nonsignificant None -- -- N-acetylneuraminate 9-O-acetyltransferase 2.3.1.45 -- O-acetyltransferase R General function prediction only ; IPR012419 [Cas1p 10 TM acyl transferase domain] -- -- A0A1L1SVG6 Choline transporter-like protein Slc44a2 451.4 431 428.6 511.9 512.8 510 0.854238613409787 0.00861084463711248 -0.227288982536263 Nonsignificant None -- -- solute carrier family 44 (choline transporter-like protein), member 2/4/5 -- ko05231 Choline metabolism in cancer Choline transporter-like protein I Lipid transport and metabolism ; IPR007603 [Choline transporter-like] -- -- Q9R1S8 Calpain-7 Capn7 139.8 148.7 183.3 201.9 207 193.3 0.783460644304218 0.0349550107959015 -0.352067289485215 Nonsignificant None 3 Molecular Function:calcium-dependent cysteine-type endopeptidase activity (GO:0004198),Cellular Component:intracellular (GO:0005622),Biological Process:proteolysis (GO:0006508) calpain-7 3.4.22.- -- Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) OT Posttranslational modification, protein turnover, chaperones ; Signal transduction mechanisms ; IPR001300 [Peptidase C2, calpain, catalytic domain] ; IPR007330[MIT] ; IPR022682[Peptidase C2, calpain, large subunit, domain III] -- -- Q3UU11 Peptidylprolyl isomerase Fkbp7 630.8 595.9 702.8 712.1 704.7 652.2 0.932576123731271 0.273762498200235 -0.100706601318755 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) FK506-binding protein 7 5.2.1.8 -- FKBP-type peptidyl-prolyl cis-trans isomerase O Posttranslational modification, protein turnover, chaperones ; IPR001179 [FKBP-type peptidyl-prolyl cis-trans isomerase domain] ; IPR002048[EF-hand domain] -- -- Q3TDA1 Oxysterol-binding protein Osbpl2 186.8 205.4 186.3 230.6 252.6 251.9 0.786967759488505 0.0054940057286323 -0.345623562304301 Nonsignificant None -- -- oxysterol-binding protein-related protein 1/2 -- -- Oxysterol-binding protein T Signal transduction mechanisms ; IPR000648 [Oxysterol-binding protein] -- -- A0A338P6E8 High mobility group protein HMG-I/HMG-Y Hmga1 878.3 786.9 826.7 853 787.9 844.9 1.00245393836994 0.954459227860416 0.00353594798996572 Nonsignificant None -- -- high mobility group AT-hook protein 1 -- -- -- -- -- -- -- HMGI/HMGY Q9DBL9 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 Abhd5 105.6 85.3 86.5 84.5 95.7 86.5 1.04011998500187 0.656072360384004 0.0567499627726766 Nonsignificant None -- -- abhydrolase domain-containing protein 5 2.3.1.51 ko04923 Regulation of lipolysis in adipocytes Predicted hydrolase/acyltransferase (alpha/beta hydrolase superfamily) R General function prediction only ; IPR000073 [Alpha/beta hydrolase fold-1] -- -- Q543H3 Ornithine transcarbamylase, mitochondrial Otc 548.1 528.2 866 931.5 776.5 844.1 0.761059519611301 0.160812741021313 -0.393918808976887 Nonsignificant None 3 Biological Process:cellular amino acid metabolic process (GO:0006520),Molecular Function:amino acid binding (GO:0016597),Molecular Function:carboxyl- or carbamoyltransferase activity (GO:0016743) ornithine carbamoyltransferase 2.1.3.3 ko00220 Arginine biosynthesis ko01100 Metabolic pathways ko01230 Biosynthesis of amino acids Ornithine carbamoyltransferase OTC/ARG3 E Amino acid transport and metabolism ; IPR006131 [Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain] ; IPR006132[Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding] -- -- Q8R4H2 Rho guanine nucleotide exchange factor 12 Arhgef12 254 269.2 291.8 336.2 341.5 319.2 0.817534356505166 0.00925058632926052 -0.290648734407385 Nonsignificant None 4 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Molecular Function:protein binding (GO:0005515),Cellular Component:cytoplasm (GO:0005737),Biological Process:regulation of Rho protein signal transduction (GO:0035023) Rho guanine nucleotide exchange factor 12 -- ko04270 Vascular smooth muscle contraction ko04360 Axon guidance ko04611 Platelet activation ko04810 Regulation of actin cytoskeleton ko05152 Tuberculosis ko05200 Pathways in cancer ko05205 Proteoglycans in cancer Predicted guanine nucleotide exchange factor T Signal transduction mechanisms ; IPR000219 [Dbl homology (DH) domain] ; IPR001478[PDZ domain] ; IPR015212[Regulator of G protein signalling-like domain] -- -- Q8K2I1 Protein farnesyltransferase subunit beta Fntb 395.4 411.7 432.2 460.4 507.5 458.8 0.86864792878671 0.0312535507653445 -0.20315653731172 Nonsignificant None 1 Molecular Function:catalytic activity (GO:0003824) protein farnesyltransferase subunit beta 2.5.1.58 ko00900 Terpenoid backbone biosynthesis Beta subunit of farnesyltransferase O Posttranslational modification, protein turnover, chaperones ; IPR001330 [PFTB repeat] -- -- Q9CQK7 RWD domain-containing protein 1 Rwdd1 582.1 560.1 590.2 487.7 517.6 555.6 1.10987250944968 0.057240314847167 0.15039396436972 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Uncharacterized conserved protein, contains RWD domain S Function unknown ; IPR006575 [RWD domain] ; IPR032378[ZC3H15/TMA46 family, C-terminal] -- -- Q4FJT5 Pltp protein Pltp 75.9 70.3 81.9 70 73.8 68.6 1.07391713747646 0.229316029806122 0.102882680507984 Nonsignificant None 1 Molecular Function:lipid binding (GO:0008289) phospholipid transfer protein -- ko03320 PPAR signaling pathway ko04979 Cholesterol metabolism BPI/LBP/CETP family protein V Defense mechanisms ; IPR001124 [Lipid-binding serum glycoprotein, C-terminal] ; IPR017942[Lipid-binding serum glycoprotein, N-terminal] -- -- H3BLL3 Leucine-rich repeat and calponin homology domain-containing protein 4 Lrch4 78.2 73.3 67.3 72.3 82.8 79.7 0.931856899488927 0.295106974457434 -0.101819670317496 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Leucine-rich repeat (LRR) protein, contains calponin homology domain Z Cytoskeleton ; IPR001611 [Leucine-rich repeat] ; IPR001715[Calponin homology domain] -- -- B2RY04 Dedicator of cytokinesis protein 5 Dock5 826.2 799 664.1 545.5 633.3 620.3 1.27246956811739 0.0458529707062897 0.347631153785361 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) dedicator of cytokinesis protein 5 -- -- Signaling protein DOCK180 T Signal transduction mechanisms ; IPR001452 [SH3 domain] ; IPR010703[Dedicator of cytokinesis, C-terminal] ; IPR027007[DHR-1 domain] ; IPR032376[Dedicator of cytokinesis, N-terminal domain] -- -- Q9ER73 Elongator complex protein 4 Elp4 330.1 355.6 311.6 324.4 333.6 358.1 0.981497884066529 0.719281666569922 -0.0269429373844193 Nonsignificant None 1 Cellular Component:Elongator holoenzyme complex (GO:0033588) elongator complex protein 4 -- -- RNA polymerase II elongator complex, subunit ELP4 BK Chromatin structure and dynamics ; Transcription ; IPR008728 [Elongator complex protein 4] -- -- O89116 Vesicle transport through interaction with t-SNAREs homolog 1A Vti1a 184.9 223.3 224.2 243.4 260.4 222.6 0.870594713656388 0.138186021107927 -0.199926834932544 Nonsignificant None 2 Biological Process:intracellular protein transport (GO:0006886),Cellular Component:membrane (GO:0016020) vesicle transport through interaction with t-SNAREs 1 -- ko04130 SNARE interactions in vesicular transport V-SNARE U Intracellular trafficking, secretion, and vesicular transport ; IPR007705 [Vesicle transport v-SNARE, N-terminal] -- -- I3RSH5 E3 ubiquitin-protein ligase Wwp2 265.9 283.9 197.3 181.5 179 204.6 1.32206689081578 0.092960897782531 0.40279517276607 Nonsignificant None 2 Molecular Function:ubiquitin-protein transferase activity (GO:0004842),Molecular Function:protein binding (GO:0005515) NEDD4-like E3 ubiquitin-protein ligase WWP2 2.3.2.26 ko04120 Ubiquitin mediated proteolysis Ubiquitin protein ligase RSP5/NEDD4 O Posttranslational modification, protein turnover, chaperones ; IPR000569 [HECT domain] ; IPR001202[WW domain] -- -- Q3UL64 Exo-alpha-sialidase Neu1 602.9 650.7 570.9 714.8 723.9 699 0.853487392992469 0.0126837972055004 -0.228558251770934 Nonsignificant None -- -- sialidase-1 3.2.1.18 ko00511 Other glycan degradation ko00600 Sphingolipid metabolism ko04142 Lysosome -- -- -- IPR011040 [Sialidases] -- -- D3Z223 Phosphoglycerate mutase (Fragment) Bpgm 437.9 421.5 500.3 518.4 563.6 515.6 0.851089133700551 0.0502088242674534 -0.232617863077379 Nonsignificant None -- -- -- -- ko00010 Glycolysis / Gluconeogenesis ko00260 Glycine, serine and threonine metabolism ko01100 Metabolic pathways Phosphoglycerate mutase G Carbohydrate transport and metabolism ; IPR013078 [Histidine phosphatase superfamily, clade-1] -- -- A0A494B9V8 Protein prenyltransferase alpha subunit repeat-containing 1 Ptar1 806 812.4 859.2 848.1 835.7 833.5 0.984229134390021 0.488680482155008 -0.0229338722438411 Nonsignificant None 2 Molecular Function:protein prenyltransferase activity (GO:0008318),Biological Process:protein prenylation (GO:0018342) protein prenyltransferase alpha subunit repeat containing protein 1 -- -- -- -- -- IPR002088 [Protein prenyltransferase, alpha subunit] -- -- Q5XK33 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial Sdhc 370.9 378.9 461.6 566.8 516.3 562.4 0.736189608021878 0.0120606085835053 -0.441850709959082 Nonsignificant None -- -- succinate dehydrogenase (ubiquinone) cytochrome b560 subunit -- ko00020 Citrate cycle (TCA cycle) ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko01200 Carbon metabolism ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Succinate dehydrogenase, cytochrome b subunit G Carbohydrate transport and metabolism ; IPR000701 [Succinate dehydrogenase/Fumarate reductase, transmembrane subunit] -- -- Q542D8 Uncharacterized protein Mbnl3 76.8 125 137.7 167.3 175.9 124.9 0.725272377697073 0.153042010045568 -0.46340519057986 Nonsignificant None -- -- muscleblind -- -- C3H1-type Zn-finger protein K Transcription ; -- -- -- Q91VS7 Microsomal glutathione S-transferase 1 Mgst1 679.9 651.6 812.2 698.5 777.6 749.9 0.963027852650494 0.642063265455449 -0.0543505706507625 Nonsignificant None -- -- glutathione S-transferase 2.5.1.18 ko00480 Glutathione metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko01524 Platinum drug resistance ko05200 Pathways in cancer ko05204 Chemical carcinogenesis ko05225 Hepatocellular carcinoma ko05418 Fluid shear stress and atherosclerosis -- -- -- IPR001129 [Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein] -- -- Q91YJ2 Sorting nexin-4 Snx4 539.3 501.7 475.6 460.8 435.9 492 1.09210052567149 0.158121753454174 0.127105659566167 Nonsignificant None 1 Molecular Function:phosphatidylinositol binding (GO:0035091) sorting nexin-4 -- ko04144 Endocytosis Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins U Intracellular trafficking, secretion, and vesicular transport ; IPR001683 [Phox homologous domain] -- -- Q8R4K2 Interleukin-1 receptor-associated kinase 4 Irak4 447.7 451.6 471.8 441.9 454.7 422.8 1.03918447779294 0.221237894701392 0.0554517866505478 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) interleukin-1 receptor-associated kinase 4 2.7.11.1 ko04010 MAPK signaling pathway ko04064 NF-kappa B signaling pathway ko04620 Toll-like receptor signaling pathway ko04621 NOD-like receptor signaling pathway ko04722 Neurotrophin signaling pathway ko05133 Pertussis ko05140 Leishmaniasis ko05142 Chagas disease (American trypanosomiasis) ko05145 Toxoplasmosis ko05152 Tuberculosis ko05162 Measles ko05164 Influenza A Serine/threonine protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q8C6F0 Peroxisomal assembly protein PEX3 Pex3 163.6 157.5 178 184.8 194.3 186.5 0.882425742574257 0.0303119440567511 -0.180453216307907 Nonsignificant None 2 Cellular Component:integral component of peroxisomal membrane (GO:0005779),Biological Process:peroxisome organization (GO:0007031) peroxin-3 -- ko04146 Peroxisome Peroxisomal assembly protein PEX3 MU Cell wall/membrane/envelope biogenesis ; Intracellular trafficking, secretion, and vesicular transport ; IPR006966 [Peroxin-3] -- -- Q8BRW2 C1q domain-containing protein Adipoq 1015.4 1030.8 1106.2 1139.3 1101.1 1150.8 0.929582448690729 0.0666707458011821 -0.105345265200307 Nonsignificant None -- -- adiponectin -- ko03320 PPAR signaling pathway ko04152 AMPK signaling pathway ko04211 Longevity regulating pathway ko04920 Adipocytokine signaling pathway ko04930 Type II diabetes mellitus ko04932 Non-alcoholic fatty liver disease (NAFLD) -- -- -- IPR001073 [C1q domain] ; IPR008160[Collagen triple helix repeat] -- -- F8VPY2 Transcription initiation factor TFIID subunit 5 Taf5 66.1 59.3 59.1 72.3 69.7 72 0.86214953271028 0.0157953697190459 -0.213989980340751 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) transcription initiation factor TFIID subunit 5 -- ko03022 Basal transcription factors ko05168 Herpes simplex infection Transcription initiation factor TFIID, subunit TAF5 (also component of histone acetyltransferase SAGA) K Transcription ; IPR001680 [WD40 repeat] ; IPR007582[TFIID subunit TAF5, NTD2 domain] -- -- Q9D6T0 Nitric oxide synthase-interacting protein Nosip 557.7 566.1 586.3 447.1 475.5 499.7 1.20234830907685 0.00529172058198596 0.265854891877309 Nonsignificant None -- -- nitric oxide synthase-interacting protein -- -- Uncharacterized conserved protein S Function unknown ; IPR031790 [Nitric oxide synthase-interacting protein, zinc-finger] -- -- D3YU58 Anaphase-promoting complex subunit 7 Anapc7 135.2 140.8 154.7 156.3 170.2 152.1 0.899916422900125 0.115662717412708 -0.152137073296641 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) anaphase-promoting complex subunit 7 -- ko04110 Cell cycle ko04114 Oocyte meiosis ko04120 Ubiquitin mediated proteolysis ko04914 Progesterone-mediated oocyte maturation ko05166 HTLV-I infection Anaphase-promoting complex (APC), subunit 7 DO Cell cycle control, cell division, chromosome partitioning ; Posttranslational modification, protein turnover, chaperones ; IPR019734 [Tetratricopeptide repeat] -- -- Q05CE4 E3 ubiquitin-protein ligase Wwp1 6.8 6.8 6.6 9.4 5.5 8.6 0.859574468085106 0.452732523984277 -0.218305463813205 Nonsignificant None 2 Molecular Function:ubiquitin-protein transferase activity (GO:0004842),Molecular Function:protein binding (GO:0005515) NEDD4-like E3 ubiquitin-protein ligase WWP1 2.3.2.26 ko04120 Ubiquitin mediated proteolysis ko04144 Endocytosis Ubiquitin protein ligase RSP5/NEDD4 O Posttranslational modification, protein turnover, chaperones ; IPR000569 [HECT domain] ; IPR001202[WW domain] -- -- G5E874 Laminin subunit gamma-2 Lamc2 234.6 242 245.9 266.8 266.6 251.6 0.920382165605096 0.0258898025713061 -0.119695066390948 Nonsignificant None -- -- laminin, gamma 2 -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko05145 Toxoplasmosis ko05146 Amoebiasis ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05222 Small cell lung cancer Extracellular matrix glycoprotein Laminin subunits alpha and gamma W Extracellular structures ; IPR000034 [Laminin IV] ; IPR002049[Laminin EGF domain] -- -- Q9JL46 ATP-binding cassette protein (Fragment) Abcd4 13.1 14.5 16.2 15.5 13.4 14.8 1.00228832951945 0.977033342308886 0.00329759010057487 Nonsignificant None 2 Molecular Function:ATP binding (GO:0005524),Molecular Function:ATPase activity (GO:0016887) ATP-binding cassette, subfamily D (ALD), member 4 -- ko02010 ABC transporters ko04146 Peroxisome Long-chain acyl-CoA transporter, ABC superfamily (involved in peroxisome organization and biogenesis) IR Lipid transport and metabolism ; General function prediction only ; IPR003439 [ABC transporter-like] -- -- A0A1W2P7Q6 Exportin-T Xpot 84.5 88.3 95.3 102.8 94.8 103.4 0.890697674418605 0.0595762936090855 -0.166992267664503 Nonsignificant None 2 Biological Process:intracellular protein transport (GO:0006886),Molecular Function:Ran GTPase binding (GO:0008536) exportin-T -- ko03013 RNA transport Nuclear mRNA export factor receptor LOS1/Exportin-t (importin beta superfamily) YUJ Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; Translation, ribosomal structure and biogenesis ; IPR001494 [Importin-beta, N-terminal domain] ; IPR013598[Exportin-1/Importin-beta-like] -- -- Q3UHD6 Sorting nexin-27 Snx27 205.1 196.6 207.2 200.3 201.1 214 0.989437764055899 0.713541442100593 -0.0153191307289674 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Biological Process:signal transduction (GO:0007165),Molecular Function:phosphatidylinositol binding (GO:0035091) sorting nexin-27 -- -- Sorting nexin protein SNX27 RTU General function prediction only ; Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR000159 [Ras-associating (RA) domain] ; IPR001478[PDZ domain] ; IPR001683[Phox homologous domain] -- -- Q9CR60 Vesicle transport protein GOT1B Golt1b 172.8 168.2 134.4 182.2 189.7 172.6 0.873094582185491 0.153016188190065 -0.195790145661835 Nonsignificant None 1 Biological Process:vesicle-mediated transport (GO:0016192) -- -- -- Ferric reductase-like proteins P Inorganic ion transport and metabolism ; IPR007305 [Vesicle transport protein, Got1/SFT2-like] -- -- Q03147 Cyclin-dependent kinase 7 Cdk7 211.2 195 205.2 182.4 183.3 157.9 1.16768525592055 0.0377317904837312 0.223651454941729 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) -- -- ko03022 Basal transcription factors ko03420 Nucleotide excision repair ko04110 Cell cycle Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, kinase subunit CDK7 DKL Cell cycle control, cell division, chromosome partitioning ; Transcription ; Replication, recombination and repair ; IPR000719 [Protein kinase domain] -- -- A0A2I3BRW0 Signal peptidase complex subunit 1 Spcs1 573.4 564.2 644.6 492.3 537.5 529.3 1.14309537553717 0.0621229233437087 0.192945781569903 Nonsignificant None 4 Cellular Component:signal peptidase complex (GO:0005787),Biological Process:signal peptide processing (GO:0006465),Molecular Function:peptidase activity (GO:0008233),Cellular Component:integral component of membrane (GO:0016021) signal peptidase complex subunit 1 3.4.-.- ko03060 Protein export Signal peptidase subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR009542 [Microsomal signal peptidase 12kDa subunit] -- -- Q9JKS4 LIM domain-binding protein 3 Ldb3 367 367 370.6 406.2 414.2 346.2 0.946854105948911 0.437167120100913 -0.0787859467427024 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:zinc ion binding (GO:0008270) LIM domain-binding protein 3 -- -- Adaptor protein Enigma and related PDZ-LIM proteins TZ Signal transduction mechanisms ; Cytoskeleton ; IPR001478 [PDZ domain] ; IPR001781[Zinc finger, LIM-type] ; IPR031847[Domain of unknown function DUF4749] -- -- Q9D1R2 Protein KTI12 homolog Kti12 342.6 329.2 303.1 269.3 281.5 272.4 1.18428085519922 0.0141692925757699 0.244011260319566 Nonsignificant None -- -- protein KTI12 -- -- RNA polymerase II elongator associated protein R General function prediction only ; IPR013641 [Protein KTI12/L-seryl-tRNA(Sec) kinase] -- -- P60060 Protein transport protein Sec61 subunit gamma Sec61g 15.1 17.6 23.1 17.1 25.6 21.8 0.865116279069768 0.442965804047623 -0.209034038481429 Nonsignificant None 3 Biological Process:protein targeting (GO:0006605),Biological Process:intracellular protein transport (GO:0006886),Cellular Component:membrane (GO:0016020) protein transport protein SEC61 subunit gamma and related proteins -- ko03060 Protein export ko04141 Protein processing in endoplasmic reticulum ko04145 Phagosome Preprotein translocase, gamma subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR001901 [Protein translocase complex, SecE/Sec61-gamma subunit] -- -- Q8BIY6 Rho GTPase-activating protein 26 Arhgap26 35.5 30.9 26.7 46.4 40.3 43.1 0.717257318952234 0.0167421261095034 -0.479437310440345 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Biological Process:signal transduction (GO:0007165) Rho GTPase-activating protein 26 -- -- Oligophrenin-1 and related Rho GTPase-activating proteins T Signal transduction mechanisms ; IPR000198 [Rho GTPase-activating protein domain] ; IPR001452[SH3 domain] -- -- O35621 Phosphomannomutase 1 Pmm1 35.3 32.6 41.2 36 31.8 37.3 1.03805899143673 0.682977588154596 0.053888432361429 Nonsignificant None 3 Molecular Function:phosphomannomutase activity (GO:0004615),Cellular Component:cytoplasm (GO:0005737),Biological Process:GDP-mannose biosynthetic process (GO:0009298) phosphomannomutase 5.4.2.8 ko00051 Fructose and mannose metabolism ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways Phosphomannomutase I Lipid transport and metabolism ; IPR005002 [Phosphomannomutase] -- -- Q78IS1 Transmembrane emp24 domain-containing protein 3 Tmed3 509.3 494.8 595.7 657 595.6 681.4 0.827197518097208 0.0514855836785937 -0.273696237854222 Nonsignificant None 2 Biological Process:transport (GO:0006810),Cellular Component:integral component of membrane (GO:0016021) p24 family protein gamma-4 -- -- emp24/gp25L/p24 family of membrane trafficking proteins U Intracellular trafficking, secretion, and vesicular transport ; IPR009038 [GOLD domain] -- -- Q9ERR1 Nuclear distribution protein nudE-like 1 Ndel1 400.3 531.4 376.4 503.3 476.4 400.8 0.94755523361101 0.694380988948966 -0.0777180535200476 Nonsignificant None -- -- nuclear distribution protein NudE-like 1 -- -- LIS1-interacting protein NUDE Z Cytoskeleton ; IPR006964 [NUDE domain] -- -- Q8BJ56 Patatin-like phospholipase domain-containing protein 2 Pnpla2 154.6 130.1 123.9 134.1 136 143.4 0.988149939540508 0.875622803781169 -0.01719812532541 Nonsignificant None 1 Biological Process:lipid metabolic process (GO:0006629) patatin-like phospholipase domain-containing protein 2 3.1.1.3 ko00561 Glycerolipid metabolism ko01100 Metabolic pathways ko04923 Regulation of lipolysis in adipocytes Adiponutrin and related vesicular transport proteins; predicted alpha/beta hydrolase U Intracellular trafficking, secretion, and vesicular transport ; IPR002641 [Patatin/Phospholipase A2-related] -- -- P82343 N-acylglucosamine 2-epimerase Renbp 400.4 400.6 411.3 455.7 444.9 442 0.902949500968271 0.00139843350130363 -0.147282790171119 Nonsignificant None -- -- N-acylglucosamine 2-epimerase 5.1.3.8 ko00520 Amino sugar and nucleotide sugar metabolism -- -- -- -- -- -- Q9ES82 Popeye domain-containing protein 2 Popdc2 180.9 198.2 172.3 214.1 207.4 219.3 0.860486891385768 0.0234768606121923 -0.216774880398519 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) -- -- -- -- -- -- IPR006916 [Popeye protein] -- -- Q8BHL3 TBC1 domain family member 10B Tbc1d10b 146.2 144.8 152.5 162.2 173.7 161.6 0.891457286432161 0.0172800327748951 -0.165762421129947 Nonsignificant None -- -- TBC1 domain family member 10 -- -- PDZ-domain interacting protein EPI64, contains TBC domain U Intracellular trafficking, secretion, and vesicular transport ; IPR000195 [Rab-GTPase-TBC domain] -- -- Q80Y55 BSD domain-containing protein 1 Bsdc1 288 298.1 291 260.7 285.2 287.8 1.05205709487825 0.18853480497922 0.0732130014577468 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein, contains BSD domain S Function unknown ; IPR005607 [BSD domain] -- -- Q9DCB8 Iron-sulfur cluster assembly 2 homolog, mitochondrial Isca2 224.6 247.4 234.4 314.5 312.1 306.6 0.756965280754394 0.000418096530736507 -0.401700964335733 Nonsignificant None -- -- iron-sulfur cluster assembly 2 -- -- Mitochondrial Fe-S cluster biosynthesis protein ISA2 (contains a HesB-like domain) CU Energy production and conversion ; Intracellular trafficking, secretion, and vesicular transport ; IPR000361 [FeS cluster biogenesis] -- -- Q8CEX1 CHCH domain-containing protein (Fragment) 873.9 799.9 446.7 428 445.1 508 1.53537035696184 0.139788198360068 0.618586699702634 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR010625 [CHCH] -- -- D3YVS7 Cysteine-rich and transmembrane domain-containing protein 1 (Fragment) Cystm1 397.3 392.2 448.1 447.2 501.8 417.3 0.905803996194101 0.232320265238245 -0.142729190654235 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q8CIG9 F-box/LRR-repeat protein 8 Fbxl8 218.8 225.4 234.6 269.9 267.2 244.2 0.868808396262639 0.0217136978511811 -0.202890049309614 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) F-box and leucine-rich repeat protein 8 -- -- -- -- -- IPR001810 [F-box domain] -- -- A0A2I3BPP1 Tuberin Tsc2 326.3 320.4 321.2 302.6 300.1 302.9 1.06879416961131 0.000534495015766542 0.0959840428873687 Nonsignificant None 3 Molecular Function:GTPase activator activity (GO:0005096),Biological Process:positive regulation of GTPase activity (GO:0043547),Biological Process:regulation of small GTPase mediated signal transduction (GO:0051056) tuberous sclerosis 2 -- ko04072 Phospholipase D signaling pathway ko04115 p53 signaling pathway ko04140 Autophagy - animal ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04152 AMPK signaling pathway ko04211 Longevity regulating pathway ko04218 Cellular senescence ko04910 Insulin signaling pathway ko04919 Thyroid hormone signaling pathway ko05165 Human papillomavirus infection ko05231 Choline metabolism in cancer Tuberin - Rap/ran-GTPase-activating protein DT Cell cycle control, cell division, chromosome partitioning ; Signal transduction mechanisms ; IPR000331 [Rap GTPase activating protein domain] ; IPR018515[Tuberin-type domain] ; IPR024584[Tuberin, N-terminal] -- -- Q8R2S3 Nucleolar protein 3 (Apoptosis repressor with CARD domain) Nol3 152.3 151.6 130 168.5 169.1 171.9 0.85161923454367 0.0721774002223066 -0.231719560236434 Nonsignificant None 1 Biological Process:regulation of apoptotic process (GO:0042981) -- -- -- -- -- -- IPR001315 [CARD domain] -- -- Q6KAU3 MFLJ00023 protein (Fragment) Mrps25 243.8 202 263.5 247.9 240.1 255.3 0.954258038477062 0.576306207911147 -0.0675486604235817 Nonsignificant None -- -- small subunit ribosomal protein S25 -- -- Putative mitochondrial ribosomal protein mRpS25 J Translation, ribosomal structure and biogenesis ; IPR007741 [Ribosomal protein/NADH dehydrogenase domain] -- -- S4R2J8 Bridging integrator 2 Bin2 453.3 494.6 417.6 373.7 350.7 353.8 1.26646262289 0.0149121688797069 0.340804499421551 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:cytoplasm (GO:0005737) bridging integrator 2 -- -- Amphiphysin U Intracellular trafficking, secretion, and vesicular transport ; IPR004148 [BAR domain] -- -- E9PUH7 Nuclear factor 1 Nfix 90.3 96.5 88.7 96.7 108.9 96.2 0.912856196156395 0.140913392637951 -0.131540487068164 Nonsignificant None 3 Cellular Component:intracellular (GO:0005622),Cellular Component:nucleus (GO:0005634),Biological Process:DNA replication (GO:0006260) nuclear factor I/X -- -- Nuclear factor I K Transcription ; IPR000647 [CTF transcription factor/nuclear factor 1] ; IPR003619[MAD homology 1, Dwarfin-type] ; IPR019548[CTF transcription factor/nuclear factor 1, N-terminal] -- CTF/NFI Q543B5 Mitogen-activated protein kinase kinase kinase 7 Map3k7 146.5 138.2 125.6 116.6 136.9 118.4 1.10325356278569 0.223262882905198 0.141764406280547 Nonsignificant None 2 Molecular Function:protein kinase activity (GO:0004672),Biological Process:protein phosphorylation (GO:0006468) mitogen-activated protein kinase kinase kinase 7 2.7.11.25 ko04010 MAPK signaling pathway ko04064 NF-kappa B signaling pathway ko04140 Autophagy - animal ko04152 AMPK signaling pathway ko04310 Wnt signaling pathway ko04380 Osteoclast differentiation ko04520 Adherens junction ko04620 Toll-like receptor signaling pathway ko04621 NOD-like receptor signaling pathway ko04622 RIG-I-like receptor signaling pathway ko04657 IL-17 signaling pathway ko04660 T cell receptor signaling pathway ko04668 TNF signaling pathway ko05140 Leishmaniasis ko05145 Toxoplasmosis ko05162 Measles ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection ko05418 Fluid shear stress and atherosclerosis Tyrosine kinase specific for activated (GTP-bound) p21cdc42Hs T Signal transduction mechanisms ; IPR001245 [Serine-threonine/tyrosine-protein kinase catalytic domain] -- -- D3YZP9 Coiled-coil domain-containing protein 6 Ccdc6 268.1 247 249.2 201.7 223.2 217.2 1.19031303535275 0.0117315859377433 0.251341031652323 Nonsignificant None -- -- coiled-coil domain-containing protein 6 -- ko05200 Pathways in cancer ko05216 Thyroid cancer Uncharacterized conserved protein H4 S Function unknown ; IPR019152 [Protein of unknown function DUF2046] -- -- Q3U0P5 Ectonucleoside triphosphate diphosphohydrolase 6 Entpd6 292.7 251.3 255.2 262.3 270.5 290.3 0.970963430931843 0.636399283587855 -0.0425111339563565 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) ectonucleoside triphosphate diphosphohydrolase 5/6 3.6.1.6 ko00230 Purine metabolism ko00240 Pyrimidine metabolism Nucleoside phosphatase F Nucleotide transport and metabolism ; IPR000407 [Nucleoside phosphatase GDA1/CD39] -- -- G3X8S1 Mitochondrial import inner membrane translocase subunit TIM14 Dnajc19 211.4 220.5 282.7 259.3 254.5 245 0.941750131787032 0.553275279685646 -0.0865837648262055 Nonsignificant None -- -- DnaJ homolog subfamily C member 19 -- -- Molecular chaperone (DnaJ superfamily) O Posttranslational modification, protein turnover, chaperones ; -- -- -- A2A591 Keratin-associated protein 3-1 Krtap3-1 432.7 335.6 434.4 284.7 251.5 247.6 1.53444756315387 0.0158275091317404 0.617719345269717 Significant up 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:keratin filament (GO:0045095) -- -- -- Ultrahigh sulfur keratin-associated protein W Extracellular structures ; IPR007659 [Keratin, high-sulphur matrix protein] -- -- Q8C407 Protein YIPF4 Yipf4 558.7 546.6 632.2 546.5 546.3 507.7 1.0855982505467 0.198895606758236 0.118490300952651 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) -- -- -- Rab GTPase interacting factor, Golgi membrane protein U Intracellular trafficking, secretion, and vesicular transport ; IPR006977 [Yip1 domain] -- -- Q6SLK2 Non-specific serine/threonine protein kinase Wnk1 177.3 146.3 140.1 133.3 123.5 125.4 1.21323914181057 0.084362692884667 0.278863948397069 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) WNK lysine deficient protein kinase 2.7.11.1 -- Serine/threonine protein kinase R General function prediction only ; IPR000719 [Protein kinase domain] ; IPR024678[Serine/threonine-protein kinase OSR1/WNK, CCT domain] -- -- Q3UNZ6 Uncharacterized protein (Fragment) Arhgap27 166.6 172.9 183 209.2 188.2 204.4 0.86822864739116 0.0292230101256214 -0.20385306947773 Nonsignificant None 1 Biological Process:signal transduction (GO:0007165) Rho GTPase-activating protein 12/27 -- -- Predicted Rho GTPase-activating protein T Signal transduction mechanisms ; IPR000198 [Rho GTPase-activating protein domain] ; IPR001849[Pleckstrin homology domain] -- -- A2ALU4 Protein Shroom2 Shroom2 191.7 180.3 178.6 180.3 207 178.2 0.973651635720601 0.649956056737284 -0.0385224142816217 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:actin filament binding (GO:0051015) protein Shroom -- -- -- -- -- IPR001478 [PDZ domain] ; IPR014799[Apx/Shrm Domain 2] ; IPR014800[Apx/Shrm Domain 1] -- -- A3KGR9 Histocompatibility 13 (Fragment) H13 578.8 572 682.2 604.1 615.1 583.3 1.01692094313454 0.796313696054692 0.0242075264117009 Nonsignificant None 2 Molecular Function:aspartic-type endopeptidase activity (GO:0004190),Cellular Component:integral component of membrane (GO:0016021) minor histocompatibility antigen H13 3.4.23.- -- Uncharacterized conserved protein S Function unknown ; IPR007369 [Peptidase A22B, signal peptide peptidase] -- -- Q8C8B2 Rho-GAP domain-containing protein Arhgap6 73.8 82 71.4 67.2 66.4 73.1 1.09917755200774 0.149932439720976 0.136424446079235 Nonsignificant None 1 Biological Process:signal transduction (GO:0007165) Rho GTPase-activating protein 6 -- -- Rho GTPase-activating protein TZ Signal transduction mechanisms ; Cytoskeleton ; IPR000198 [Rho GTPase-activating protein domain] -- -- P34928 Apolipoprotein C-I Apoc1 821.8 1123.9 713 510.7 551.8 503.8 1.69743982634234 0.0954416033233804 0.763360432333796 Nonsignificant None 2 Cellular Component:extracellular region (GO:0005576),Biological Process:lipoprotein metabolic process (GO:0042157) apolipoprotein C-I -- ko04979 Cholesterol metabolism -- -- -- IPR006781 [Apolipoprotein C-I] -- -- Q3URS9 Mitochondrial potassium channel Ccdc51 53.8 58.5 58.2 61.3 65.1 60.1 0.914209115281501 0.0673109500752991 -0.129403891231065 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q80U27 Kinesin-like protein (Fragment) Kif3b 99.2 100.9 109.4 105.4 87.6 110.1 1.02111514351699 0.791366289701545 0.0301455573172981 Nonsignificant None 4 Molecular Function:microtubule motor activity (GO:0003777),Molecular Function:ATP binding (GO:0005524),Biological Process:microtubule-based movement (GO:0007018),Molecular Function:microtubule binding (GO:0008017) kinesin family member 3B -- -- Kinesin-like protein Z Cytoskeleton ; IPR001752 [Kinesin motor domain] -- -- Q9CQS8 Protein transport protein Sec61 subunit beta Sec61b 292 260.7 254.7 250.7 251.5 259.7 1.05971912324452 0.272038845445893 0.0836819315820042 Nonsignificant None -- -- protein transport protein SEC61 subunit beta -- ko03060 Protein export ko04141 Protein processing in endoplasmic reticulum ko04145 Phagosome Sec61 protein translocation complex, beta subunit O Posttranslational modification, protein turnover, chaperones ; IPR016482 [Protein transport protein SecG/Sec61-beta/Sbh] -- -- A0A2R8VI94 Leukocyte surface antigen CD47 Cd47 29.8 31.9 47.5 42.3 44.9 50.6 0.792452830188679 0.192971882334773 -0.335603031784439 Nonsignificant None -- -- CD47 antigen (Rh-related antigen, integrin-associated signal transducer) -- ko04512 ECM-receptor interaction -- -- -- IPR013147 [CD47 transmembrane] ; IPR013270[CD47 immunoglobulin-like] -- -- B7ZWK9 2310021P13Rik protein Zswim8 35 34 31 37.2 35.9 30.3 0.967117988394584 0.665736773224642 -0.0482361856528475 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; -- -- -- Q0P5W2 Thioredoxin domain containing 13 Tmx4 313.6 319.8 287.4 332.8 343.7 313.1 0.930476960388036 0.161452876552968 -0.103957666844139 Nonsignificant None 1 Biological Process:cell redox homeostasis (GO:0045454) -- -- -- Thiol-disulfide isomerase and thioredoxin OC Posttranslational modification, protein turnover, chaperones ; Energy production and conversion ; IPR013766 [Thioredoxin domain] -- -- B1AXC8 Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 (Fragment) Chchd7 123.6 118.4 143.7 146.3 145.4 151 0.871244635193133 0.0741225564490531 -0.198850227469104 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; -- -- -- P45700 Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA Man1a1 179 163 132.4 134.9 150.9 140 1.11413809300141 0.325353579706997 0.15592806009371 Nonsignificant None 3 Molecular Function:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity (GO:0004571),Molecular Function:calcium ion binding (GO:0005509),Cellular Component:membrane (GO:0016020) mannosyl-oligosaccharide alpha-1,2-mannosidase 3.2.1.113 ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways ko04141 Protein processing in endoplasmic reticulum Mannosyl-oligosaccharide alpha-1,2-mannosidase and related glycosyl hydrolases G Carbohydrate transport and metabolism ; IPR001382 [Glycoside hydrolase family 47] -- -- Q9JHE7 Protein TSSC4 Tssc4 775.5 851.3 889.7 763 861.5 792.9 1.04099445685447 0.498661181588556 0.0579623865145096 Nonsignificant None -- -- -- -- -- -- -- -- IPR029338 [Tumour suppressing sub-chromosomal transferable candidate 4] -- -- Q3U8S0 Adaptor-related protein complex 3, sigma 1 subunit Ap3s1 547.3 613.1 658.6 679.4 707.3 667.1 0.885675333528094 0.0854024128293316 -0.175150155192145 Nonsignificant None -- -- AP-3 complex subunit sigma -- ko04142 Lysosome Clathrin adaptor complex, small subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR022775 [AP complex, mu/sigma subunit] -- -- Q99JR6 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 Nmnat3 544.7 506.7 636.6 613.2 609.4 603.4 0.924424972617744 0.355125728058609 -0.113371861277037 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:biosynthetic process (GO:0009058) -- -- ko00760 Nicotinate and nicotinamide metabolism ko01100 Metabolic pathways Nicotinamide mononucleotide adenylyl transferase H Coenzyme transport and metabolism ; IPR004821 [Cytidyltransferase-like domain] -- -- Q8CJF7 Protein ELYS Ahctf1 271 271.1 239.6 227.5 251.5 244.9 1.07984528249758 0.203681278546376 0.110824621496885 Nonsignificant None -- -- -- -- -- -- -- -- IPR025151 [ELYS-like domain] ; IPR032040[ELYS, beta-propeller domain] -- -- P49813 Tropomodulin-1 Tmod1 96.5 75.5 86 103.2 94 102.4 0.861148197596796 0.108721308813402 -0.215666558148135 Nonsignificant None 2 Molecular Function:tropomyosin binding (GO:0005523),Biological Process:pointed-end actin filament capping (GO:0051694) tropomodulin -- -- Tropomodulin and leiomodulin Z Cytoskeleton ; IPR004934 [Tropomodulin] -- -- Q9JIQ3 Diablo IAP-binding mitochondrial protein Diablo 123 174.8 199.7 219.8 246 171.6 0.780514590524004 0.21151664115504 -0.357502493459479 Nonsignificant None 3 Cellular Component:mitochondrion (GO:0005739),Biological Process:apoptotic process (GO:0006915),Biological Process:activation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0006919) diablo -- ko04210 Apoptosis ko04215 Apoptosis - multiple species -- -- -- IPR015142 [Smac/DIABLO protein] -- -- Q9D1K2 V-type proton ATPase subunit F Atp6v1f 898.6 792.2 798.7 775.4 762.7 870.3 1.03367380833749 0.605942669881381 0.0477809928696386 Nonsignificant None 1 Biological Process:ion transmembrane transport (GO:0034220) V-type H+-transporting ATPase subunit F -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04145 Phagosome ko04150 mTOR signaling pathway ko04721 Synaptic vesicle cycle ko04966 Collecting duct acid secretion ko05323 Rheumatoid arthritis Vacuolar H+-ATPase V1 sector, subunit F C Energy production and conversion ; IPR008218 [ATPase, V1 complex, subunit F] -- -- Q3UM95 Spermatogenesis-defective protein 39 homolog Vipas39 316.2 304.5 347.3 370.8 353.3 367.9 0.886446886446887 0.0407536684912338 -0.173893903645258 Nonsignificant None 2 Cellular Component:cytoplasm (GO:0005737),Biological Process:intracellular protein transport (GO:0006886) -- -- -- Golgi integral membrane protein UR Intracellular trafficking, secretion, and vesicular transport ; General function prediction only ; IPR006925 [Vps16, C-terminal] -- -- H9H9R4 Glycosylated lysosomal membrane protein Glmp 49.9 62.1 58.8 46.4 56.3 59.8 1.05107692307692 0.636607506100705 0.0718682568173111 Nonsignificant None -- -- -- -- -- -- -- -- IPR029382 [Lysosomal transcription factor, NCU-G1] -- NCU-G1 P56873 Protein ZNRD2 Znrd2 221.4 211.9 177.5 154.3 176.3 180.9 1.1941348973607 0.102048566912087 0.25596582216416 Nonsignificant None -- -- -- -- -- Zn-ribbon-containing protein implicated in mitosis DV Cell cycle control, cell division, chromosome partitioning ; Defense mechanisms ; IPR009563 [Sjoegren syndrome/scleroderma autoantigen 1] -- -- Q920A7 AFG3-like protein 1 Afg3l1 294.6 247.2 208.8 241.8 220.8 237.7 1.07182636013137 0.548734969743084 0.100071202747177 Nonsignificant None 5 Molecular Function:metalloendopeptidase activity (GO:0004222),Molecular Function:ATP binding (GO:0005524),Biological Process:proteolysis (GO:0006508),Molecular Function:zinc ion binding (GO:0008270),Cellular Component:integral component of membrane (GO:0016021) AFG3 family protein 3.4.24.- -- AAA+-type ATPase containing the peptidase M41 domain O Posttranslational modification, protein turnover, chaperones ; IPR000642 [Peptidase M41] ; IPR003959[ATPase, AAA-type, core] ; IPR011546[Peptidase M41, FtsH extracellular] -- -- A0A571BEF4 SH3 domain-containing protein 19 Sh3d19 660.1 628.7 613.5 622.8 633.9 629.3 1.00864262990456 0.719472832598478 0.0124151066642747 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Sorbin and SH3 domain-containing protein T Signal transduction mechanisms ; IPR001452 [SH3 domain] ; IPR011511[Variant SH3 domain] -- -- Q8CAK1 Putative transferase CAF17 homolog, mitochondrial Iba57 317.8 310.9 363.2 352.7 332.5 349.2 0.958913379737046 0.464773520703092 -0.0605275948346317 Nonsignificant None -- -- transferase CAF17, mitochondrial 2.1.-.- -- Transcription factor, component of CCR4 transcriptional complex K Transcription ; IPR013977 [Glycine cleavage T-protein, C-terminal barrel domain] -- -- Q8R219 Cda protein (Fragment) Cda 142.8 152 128 182.4 181.6 187.4 0.766775480594849 0.00404013074094672 -0.383123890627508 Nonsignificant None -- -- cytidine deaminase 3.5.4.5 ko00240 Pyrimidine metabolism ko00983 Drug metabolism - other enzymes ko01100 Metabolic pathways Cytidine deaminase F Nucleotide transport and metabolism ; -- -- -- A2AUX5 Disabled homolog 2-interacting protein Dab2ip 761 735.8 380.8 386.9 375.7 407.1 1.60519791399504 0.193874131964327 0.682751186404378 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Biological Process:regulation of GTPase activity (GO:0043087) disabled homolog 2-interacting protein -- ko04210 Apoptosis ko04668 TNF signaling pathway GTPase-activating protein R General function prediction only ; IPR000008 [C2 domain] ; IPR001936[Ras GTPase-activating protein] ; IPR021887[Domain of unknown function DUF3498] -- -- A6H5Z3 Exocyst complex component 6B Exoc6b 173 146.6 160.5 140 140 148.8 1.11963619402985 0.104454671373407 0.163030030200822 Nonsignificant None 2 Cellular Component:exocyst (GO:0000145),Biological Process:vesicle docking involved in exocytosis (GO:0006904) exocyst complex component 6 -- -- Exocyst complex, subunit SEC15 U Intracellular trafficking, secretion, and vesicular transport ; IPR007225 [Exocyst complex component EXOC6/Sec15] -- -- Q542X9 Superoxide dismutase [Cu-Zn] Sod3 385.5 446.5 409.7 314.5 336.7 290.4 1.31871282922685 0.0107877778430066 0.399130428913002 Nonsignificant None 3 Biological Process:superoxide metabolic process (GO:0006801),Molecular Function:metal ion binding (GO:0046872),Biological Process:oxidation-reduction process (GO:0055114) superoxide dismutase, Cu-Zn family 1.15.1.1 -- Cu2+/Zn2+ superoxide dismutase SOD1 P Inorganic ion transport and metabolism ; IPR001424 [Superoxide dismutase, copper/zinc binding domain] -- -- Q80U35 Rho guanine nucleotide exchange factor 17 Arhgef17 275.7 269.3 311.6 321.4 276.9 292.5 0.961607543780871 0.571609867824226 -0.0564798808967472 Nonsignificant None 2 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Biological Process:regulation of Rho protein signal transduction (GO:0035023) Rho guanine nucleotide exchange factor 17 -- -- Predicted guanine nucleotide exchange factor T Signal transduction mechanisms ; IPR000219 [Dbl homology (DH) domain] -- -- Q8K0B2 Lysosomal cobalamin transport escort protein LMBD1 Lmbrd1 110.6 113.5 132.7 142.9 140.2 127.9 0.868126520681265 0.0959353468334818 -0.204022778648741 Nonsignificant None -- -- LMBR1 domain-containing protein 1 -- ko04977 Vitamin digestion and absorption -- -- -- IPR006876 [LMBR1-like membrane protein] -- -- Q9JL08 Protein S100 (Fragment) S100A1 270.1 238.3 342.3 437.2 433.5 549.3 0.599084507042254 0.0178223866112354 -0.739168570518564 Significant down -- -- -- -- -- -- -- -- IPR013787 [S100/CaBP-9k-type, calcium binding, subdomain] -- -- Q0GNC1 Inverted formin-2 Inf2 77.3 72.6 71.4 72.9 88.1 69.8 0.958838821490468 0.621875772604199 -0.060639772844471 Nonsignificant None 4 Molecular Function:actin binding (GO:0003779),Biological Process:cellular component organization (GO:0016043),Molecular Function:Rho GTPase binding (GO:0017048),Biological Process:actin cytoskeleton organization (GO:0030036) -- -- -- -- -- -- IPR003124 [WH2 domain] ; IPR010472[Formin, FH3 domain] ; IPR010473[Formin, GTPase-binding domain] ; IPR015425[Formin, FH2 domain] -- -- Q64430 Copper-transporting ATPase 1 Atp7a 319.7 309 306.9 323.2 337.8 299.3 0.974278871186088 0.527107541105862 -0.0375933159143099 Nonsignificant None 3 Molecular Function:nucleotide binding (GO:0000166),Biological Process:metal ion transport (GO:0030001),Molecular Function:metal ion binding (GO:0046872) Cu+-exporting ATPase 3.6.3.54 ko01524 Platinum drug resistance Cation transport ATPase P Inorganic ion transport and metabolism ; IPR006121 [Heavy metal-associated domain, HMA] ; IPR008250[P-type ATPase, A domain] -- -- D6RE34 Ceroid-lipofuscinosis, neuronal 6 Cln6 126.7 132.4 135.5 136.8 140.8 130.3 0.967393969110076 0.329899360460068 -0.0478245510689644 Nonsignificant None -- -- ceroid-lipofuscinosis neuronal protein 6 -- -- -- -- -- -- -- -- E9PWR4 Disco-interacting protein 2 homolog C Dip2c 263.3 275.9 241 243.4 279.5 254.5 1.00360174942115 0.952638360299193 0.00518689068536481 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) -- -- -- Predicted AMP-binding protein R General function prediction only ; IPR000873 [AMP-dependent synthetase/ligase] ; IPR010506[DMAP1-binding domain] -- -- P97287 Induced myeloid leukemia cell differentiation protein Mcl-1 homolog Mcl1 256.5 259 235.7 232.8 252.8 256.5 1.01226249831559 0.785588060463512 0.0175834559524853 Nonsignificant None 1 Biological Process:regulation of apoptotic process (GO:0042981) myeloid leukemia cell differntiation protein MCL-1 -- ko04151 PI3K-Akt signaling pathway ko04210 Apoptosis ko04630 Jak-STAT signaling pathway ko05206 MicroRNAs in cancer Anti-apoptotic Bcl-2 family proteins, prevent opening of mitochondrial porin channel T Signal transduction mechanisms ; IPR026298 [Blc2 family] -- -- Q9QZF2 Glypican-1 Gpc1 127.4 127.2 121.2 133.9 129.5 159.7 0.888206097849208 0.177151030180581 -0.171033618936295 Nonsignificant None 3 Cellular Component:proteinaceous extracellular matrix (GO:0005578),Cellular Component:membrane (GO:0016020),Molecular Function:heparan sulfate proteoglycan binding (GO:0043395) glypican 1 -- ko05205 Proteoglycans in cancer ko05418 Fluid shear stress and atherosclerosis Heparin sulfate cell surface proteoglycan T Signal transduction mechanisms ; IPR001863 [Glypican] -- -- E9Q7D5 Rho guanine nucleotide exchange factor 5 Arhgef5 313.2 301.4 319.5 316.1 328.6 317.7 0.970594347464672 0.226151345996499 -0.04305963671028 Nonsignificant None 3 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Molecular Function:protein binding (GO:0005515),Biological Process:regulation of Rho protein signal transduction (GO:0035023) Rho guanine nucleotide exchange factor 5 -- -- Putative guanine nucleotide exchange factor TIM T Signal transduction mechanisms ; IPR000219 [Dbl homology (DH) domain] ; IPR001452[SH3 domain] ; IPR029212[Rho guanine nucleotide exchange factor 5/35, N-terminal] -- -- A0A4W7N3B2 Methyltransferase N6AMT1 N6amt1 80.1 83.7 83.3 133.7 120.3 131.8 0.640487299118714 0.000439084506396101 -0.642758132720319 Significant down 1 Molecular Function:methyltransferase activity (GO:0008168) release factor glutamine methyltransferase 2.1.1.297 -- Predicted N6-DNA-methyltransferase J Translation, ribosomal structure and biogenesis ; IPR007848 [Methyltransferase small domain] -- -- G3UX48 Protein PRRC2A Prrc2a 354.3 372.8 464.3 483.8 471.8 473.1 0.83390494855463 0.143883573649438 -0.262045145346757 Nonsignificant None -- -- -- -- -- -- -- -- IPR009738 [BAT2, N-terminal] -- -- Q8C288 Phospholipid-transporting ATPase Atp9a 330.8 329.4 374.2 367 361.9 343.1 0.964925373134328 0.487406463012707 -0.0515107255348803 Nonsignificant None 2 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:metal ion binding (GO:0046872) phospholipid-translocating ATPase 3.6.3.1 -- P-type ATPase P Inorganic ion transport and metabolism ; IPR008250 [P-type ATPase, A domain] ; IPR032630[P-type ATPase, C-terminal] ; IPR032631[P-type ATPase, N-terminal] -- -- P62307 Small nuclear ribonucleoprotein F Snrpf 1563.4 1532.1 1635.1 1294.2 1310.1 1453.4 1.16583286098036 0.0191774073268011 0.221360972141554 Nonsignificant None -- -- small nuclear ribonucleoprotein F -- ko03040 Spliceosome Small nuclear ribonucleoprotein (snRNP) SMF A RNA processing and modification ; IPR001163 [LSM domain, eukaryotic/archaea-type] -- -- Q91VJ1 Interferon-inducible protein AIM2 Aim2 552.9 519.5 490.7 486.6 527.9 521.4 1.01770948629468 0.702347274351717 0.0253257907875524 Nonsignificant None -- -- absent in melanoma 2 -- ko04621 NOD-like receptor signaling pathway ko04623 Cytosolic DNA-sensing pathway -- -- -- IPR004020 [DAPIN domain] ; IPR004021[HIN-200/IF120x] -- -- Q6Y685 Transforming acidic coiled-coil-containing protein 1 Tacc1 350 375.5 346.7 336.6 337.8 350.5 1.04615084398478 0.194535188947101 0.0650908880845084 Nonsignificant None -- -- transforming acidic coiled-coil-containing protein 1 -- -- -- -- -- IPR007707 [Transforming acidic coiled-coil-containing protein] -- -- Q91ZT5 FYVE, RhoGEF and PH domain-containing protein 4 Fgd4 54.8 56.7 62.6 76.5 77.1 70.8 0.775846702317291 0.00559044694763426 -0.366156472957692 Nonsignificant None 3 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Biological Process:regulation of Rho protein signal transduction (GO:0035023),Molecular Function:metal ion binding (GO:0046872) FYVE, RhoGEF and PH domain containing 4 -- -- Predicted Rho/Rac guanine nucleotide exchange factor/faciogenital dysplasia protein 3 T Signal transduction mechanisms ; IPR000219 [Dbl homology (DH) domain] ; IPR000306[FYVE zinc finger] ; IPR001849[Pleckstrin homology domain] -- -- Q9CQ10 Charged multivesicular body protein 3 Chmp3 463.2 391.3 453.1 419.9 456 446.5 0.988808227465215 0.85281393638292 -0.0162373475250477 Nonsignificant None 1 Biological Process:vacuolar transport (GO:0007034) charged multivesicular body protein 3 -- ko04144 Endocytosis ko04217 Necroptosis Vacuolar sorting protein VPS24 U Intracellular trafficking, secretion, and vesicular transport ; IPR005024 [Snf7 family] -- -- E0CYA9 DNA polymerase epsilon subunit 4 Pole4 20.4 20.4 18.1 21.6 23 22.8 0.873887240356083 0.0325763424496492 -0.194480957351398 Nonsignificant None -- -- DNA polymerase epsilon subunit 4 2.7.7.7 ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways ko03030 DNA replication ko03410 Base excision repair ko03420 Nucleotide excision repair ko05166 HTLV-I infection DNA polymerase epsilon, subunit C L Replication, recombination and repair ; IPR003958 [Transcription factor CBF/NF-Y/archaeal histone domain] -- NF-YC Q5RKZ7 Molybdenum cofactor biosynthesis protein 1 Mocs1 239.1 212.5 188.8 223.1 254.5 216.6 0.922500720253529 0.390825265423768 -0.116378057312389 Nonsignificant None 4 Molecular Function:catalytic activity (GO:0003824),Biological Process:Mo-molybdopterin cofactor biosynthetic process (GO:0006777),Cellular Component:molybdopterin synthase complex (GO:0019008),Molecular Function:iron-sulfur cluster binding (GO:0051536) -- -- ko00790 Folate biosynthesis ko01100 Metabolic pathways Molybdenum cofactor biosynthesis pathway protein H Coenzyme transport and metabolism ; IPR002820 [Molybdopterin cofactor biosynthesis C (MoaC) domain] ; IPR007197[Radical SAM] ; IPR010505[Molybdenum cofactor synthesis C-terminal] -- -- P01872 Immunoglobulin heavy constant mu Ighm 312.5 271.8 250.9 298.6 303.4 340.9 0.885777919185491 0.185703364300138 -0.174983060950023 Nonsignificant None -- -- major histocompatibility complex, class II -- ko04145 Phagosome ko04514 Cell adhesion molecules (CAMs) ko04612 Antigen processing and presentation ko04640 Hematopoietic cell lineage ko04658 Th1 and Th2 cell differentiation ko04659 Th17 cell differentiation ko04672 Intestinal immune network for IgA production ko04940 Type I diabetes mellitus ko05140 Leishmaniasis ko05145 Toxoplasmosis ko05150 Staphylococcus aureus infection ko05152 Tuberculosis ko05164 Influenza A ko05166 HTLV-I infection ko05168 Herpes simplex infection ko05310 Asthma ko05320 Autoimmune thyroid disease ko05321 Inflammatory bowel disease (IBD) ko05322 Systemic lupus erythematosus ko05323 Rheumatoid arthritis ko05330 Allograft rejection ko05332 Graft-versus-host disease ko05416 Viral myocarditis -- -- -- IPR003597 [Immunoglobulin C1-set] -- -- Q8CBY1 Protein Smaug homolog 1 Samd4a 64.7 56 55 75.1 79.5 68.2 0.788599640933573 0.0252508871384448 -0.342635041331655 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Predicted RNA-binding protein involved in translational regulation JT Translation, ribosomal structure and biogenesis ; Signal transduction mechanisms ; IPR001660 [Sterile alpha motif domain] -- -- Q3UGB8 Derlin Derl1 141.9 134.3 111.8 141.9 139.1 137.9 0.926235378371927 0.372406147198606 -0.110549231792033 Nonsignificant None -- -- Derlin-1 -- ko04141 Protein processing in endoplasmic reticulum ko05014 Amyotrophic lateral sclerosis (ALS) Predicted membrane protein S Function unknown ; -- -- -- Q8C0J6 Ankyrin repeat domain-containing protein SOWAHC Sowahc 24.7 35.2 34.6 46.2 34.4 26.4 0.883177570093458 0.566758310670985 -0.179224562180074 Nonsignificant None -- -- -- -- -- -- -- -- IPR020683 [Ankyrin repeat-containing domain] -- -- Q920I9 WD repeat-containing protein 7 Wdr7 152.9 130.6 145.1 166.5 164.9 181.2 0.836129535700351 0.02840086211074 -0.25820162861503 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- FOG: WD40 repeat R General function prediction only ; IPR001680 [WD40 repeat] -- -- P27808 Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Mgat1 735.9 704.5 713 746.3 817.5 791.5 0.914278435868042 0.0419880698940802 -0.129294501953114 Nonsignificant None 2 Biological Process:protein glycosylation (GO:0006486),Molecular Function:acetylglucosaminyltransferase activity (GO:0008375) alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 2.4.1.101 ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways N-acetylglucosaminyltransferase I G Carbohydrate transport and metabolism ; IPR004139 [Glycosyl transferase, family 13] -- -- A0A0R4J098 Zinc finger protein 326 Zfp326 381.5 401.2 442.1 452 403 417.6 0.962439101052962 0.526763142984139 -0.0552328387519235 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634) zinc finger protein 326 -- -- -- -- -- IPR007071 [A-kinase anchoring protein 95 (AKAP95)] -- -- A0A1L1SRC3 RNA-binding protein 7 Rbm7 180.5 180.8 169.2 141.2 151.6 164.8 1.15930944055944 0.0360087586792411 0.213265699023738 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) RNA-binding protein 7 -- -- RNA binding protein (RRM superfamily) R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- A0A5F8MPL9 Dedicator of cytokinesis protein 9 Dock9 193.3 186.3 193.7 168.1 151.4 185.3 1.13569730586371 0.0861201643738278 0.183578368716064 Nonsignificant None -- -- dedicator of cytokinesis protein 9/10/11 -- -- PH domain-containing protein T Signal transduction mechanisms ; IPR001849 [Pleckstrin homology domain] ; IPR010703[Dedicator of cytokinesis, C-terminal] ; IPR021816[Dedicator of cytokinesis C/D, N-terminal] ; IPR027007[DHR-1 domain] -- -- F6ZBR8 Protein Wiz Wiz 230.9 229.9 237.1 213.7 198 211.7 1.1195059351941 0.0101924521887555 0.162862176830432 Nonsignificant None -- -- -- -- -- FOG: Zn-finger R General function prediction only ; -- -- zf-C2H2 Q6KAR6 Exocyst complex component 3 Exoc3 548.9 547.3 433.8 506.6 516.1 508 0.999542692885608 0.995677019547803 -0.000659905607364502 Nonsignificant None 2 Cellular Component:exocyst (GO:0000145),Biological Process:exocytosis (GO:0006887) exocyst complex component 3 -- -- Exocyst complex subunit SEC6 U Intracellular trafficking, secretion, and vesicular transport ; IPR010326 [Exocyst complex component EXOC3/Sec6] -- -- Q8R418 Endoribonuclease Dicer Dicer1 192.9 189.3 245.4 245.7 258.9 246.2 0.835908364411295 0.0922938953154362 -0.258583297862776 Nonsignificant None 6 Molecular Function:DNA binding (GO:0003677),Molecular Function:ribonuclease III activity (GO:0004525),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Biological Process:RNA processing (GO:0006396),Molecular Function:hydrolase activity (GO:0016787) endoribonuclease Dicer 3.1.26.- ko05206 MicroRNAs in cancer dsRNA-specific nuclease Dicer and related ribonucleases A RNA processing and modification ; IPR000999 [Ribonuclease III domain] ; IPR001650[Helicase, C-terminal] ; IPR003100[PAZ domain] ; IPR005034[Dicer dimerisation domain] ; IPR006935[Helicase/UvrB, N-terminal] -- -- A2ABV5 Mediator of RNA polymerase II transcription subunit 14 Med14 287.8 288.8 323.4 447.8 409.4 406.9 0.711968989795111 0.00235260933738042 -0.490113689711274 Nonsignificant None 3 Molecular Function:RNA polymerase II transcription cofactor activity (GO:0001104),Biological Process:regulation of transcription from RNA polymerase II promoter (GO:0006357),Cellular Component:mediator complex (GO:0016592) mediator of RNA polymerase II transcription subunit 14 -- ko04919 Thyroid hormone signaling pathway Thyroid hormone receptor-associated coactivator complex component (TRAP170) K Transcription ; IPR013947 [Mediator complex, subunit Med14] -- -- Q3TMN9 Ubiquitin-like domain-containing protein Herpud1 141.9 134.9 115.4 116.2 144.1 127.2 1.01212903225806 0.896834208761098 0.017393225143187 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein -- ko04141 Protein processing in endoplasmic reticulum Membrane-associated ER protein involved in stress response (contains ubiquitin-like domain) O Posttranslational modification, protein turnover, chaperones ; IPR000626 [Ubiquitin domain] -- -- Q8R3G1 Nuclear inhibitor of protein phosphatase 1 Ppp1r8 470.2 470.2 670.4 553.2 520.4 495 1.02690297080199 0.848036122435497 0.0382998718645687 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) nuclear inhibitor of protein phosphatase 1 3.1.4.- -- Nuclear inhibitor of phosphatase-1 R General function prediction only ; IPR000253 [Forkhead-associated (FHA) domain] -- -- F6SQH7 Polymerase delta-interacting protein 2 (Fragment) Poldip2 436.8 354.4 352.5 338.3 328.6 351.7 1.12281562929511 0.218368058370039 0.167121051034339 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) polymerase delta-interacting protein 2 -- -- Putative Mg2+ and Co2+ transporter CorD P Inorganic ion transport and metabolism ; IPR007474 [ApaG domain] ; IPR011722[Hemimethylated DNA-binding domain] -- -- A0A0R4J139 Peptide-methionine (R)-S-oxide reductase Msrb3 687.3 734.2 769.6 756.7 740.8 734.2 0.98180759062598 0.61362758787268 -0.0264877742659776 Nonsignificant None 2 Molecular Function:peptide-methionine (R)-S-oxide reductase activity (GO:0033743),Biological Process:oxidation-reduction process (GO:0055114) peptide-methionine (R)-S-oxide reductase 1.8.4.12 -- Predicted pilin-like transcription factor O Posttranslational modification, protein turnover, chaperones ; IPR002579 [Peptide methionine sulphoxide reductase MrsB] -- -- Q9CT51 Uncharacterized protein (Fragment) Rnf25 151.9 141.2 142.6 143.5 142.6 131 1.04459362263246 0.302382035815631 0.062941801025942 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:zinc ion binding (GO:0008270) E3 ubiquitin-protein ligase RNF25 2.3.2.27 -- Uncharacterized conserved protein, contains RWD domain S Function unknown ; IPR001841 [Zinc finger, RING-type] -- -- Q9D0B0 Serine/arginine-rich splicing factor 9 Srsf9 208.7 218.9 231.6 189.3 194.1 217.8 1.09647371922821 0.154281541403938 0.132871233266854 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) splicing factor, arginine/serine-rich 9 -- ko03040 Spliceosome ko05168 Herpes simplex infection Alternative splicing factor ASF/SF2 (RRM superfamily) A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- A0A024QYR9 Mitochondrial PTENalpha Pten 189.2 210.7 306.1 291.9 302.3 292 0.796659896185963 0.235694724561229 -0.327964143327403 Nonsignificant None 2 Biological Process:protein dephosphorylation (GO:0006470),Molecular Function:protein tyrosine/serine/threonine phosphatase activity (GO:0008138) -- -- ko00562 Inositol phosphate metabolism ko01521 EGFR tyrosine kinase inhibitor resistance ko04068 FoxO signaling pathway ko04070 Phosphatidylinositol signaling system ko04071 Sphingolipid signaling pathway ko04115 p53 signaling pathway ko04140 Autophagy - animal ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04218 Cellular senescence ko04510 Focal adhesion ko04931 Insulin resistance ko05161 Hepatitis B ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05206 MicroRNAs in cancer ko05213 Endometrial cancer ko05214 Glioma ko05215 Prostate cancer ko05218 Melanoma ko05222 Small cell lung cancer ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05230 Central carbon metabolism in cancer Clathrin coat dissociation kinase GAK/PTEN/Auxilin and related tyrosine phosphatases TR Signal transduction mechanisms ; General function prediction only ; IPR000340 [Dual specificity phosphatase, catalytic domain] ; IPR014020[Tensin phosphatase, C2 domain] -- -- Q8K0L9 Zinc finger and BTB domain-containing protein 20 Zbtb20 234.7 212.3 232.4 264.6 251 302.7 0.830257851643652 0.053058365541949 -0.26836863371006 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:metal ion binding (GO:0046872) zinc finger and BTB domain-containing protein 20 -- -- FOG: Zn-finger R General function prediction only ; IPR000210 [BTB/POZ domain] ; IPR007087[Zinc finger, C2H2] -- ZBTB B9EJ80 PDZ domain-containing protein 8 Pdzd8 248.1 233.7 241 225.9 210.1 235 1.07719821162444 0.108343779473348 0.107283739777054 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Biological Process:intracellular signal transduction (GO:0035556) -- -- -- Predicted protein kinase R General function prediction only ; IPR001478 [PDZ domain] ; IPR002219[Protein kinase C-like, phorbol ester/diacylglycerol-binding domain] -- -- Q6ZQ73 Cullin-associated NEDD8-dissociated protein 2 Cand2 152.3 152.1 198.9 227.9 250.8 196.6 0.745298385902562 0.0605261413833289 -0.42410995967841 Nonsignificant None -- -- -- -- -- TATA-binding protein-interacting protein R General function prediction only ; IPR013932 [TATA-binding protein interacting (TIP20)] -- -- Q91YR5 eEF1A lysine and N-terminal methyltransferase Mettl13 249.9 262.3 240.1 255.2 256.1 253.6 0.983527258465159 0.581073009649008 -0.0239630575258583 Nonsignificant None 2 Biological Process:metabolic process (GO:0008152),Molecular Function:methyltransferase activity (GO:0008168) -- -- -- Predicted spermine/spermidine synthase E Amino acid transport and metabolism ; IPR013216 [Methyltransferase type 11] -- -- Q9DCA2 28S ribosomal protein S11, mitochondrial Mrps11 717.7 709.8 694.6 712.3 673.1 696.3 1.01940721525676 0.366789385986955 0.027730469635415 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S11 -- ko03010 Ribosome Mitochondrial/chloroplast ribosomal protein S11 J Translation, ribosomal structure and biogenesis ; IPR001971 [Ribosomal protein S11] -- -- Q9JM93 ADP-ribosylation factor-like protein 6-interacting protein 4 Arl6ip4 193.3 196.9 232.2 189.5 199.3 189.7 1.07588591184097 0.317531733723384 0.10552510099134 Nonsignificant None -- -- -- -- -- -- -- -- IPR019532 [Nuclear RNA-splicing-associated protein, SR-25] -- -- Q6LD55 Apolipoprotein A-II Apoa2 238.9 268.8 258.3 347.8 362.3 435.5 0.668645251396648 0.0113625026522417 -0.580687100451937 Nonsignificant None -- -- apolipoprotein A-II -- ko03320 PPAR signaling pathway ko04979 Cholesterol metabolism -- -- -- -- -- -- P33215 Protein NEDD1 Nedd1 277.8 260.2 149.5 187.9 167.1 186.3 1.27009052281544 0.297349110960068 0.344931325472104 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) protein NEDD1 -- -- Nuclear protein COP1 T Signal transduction mechanisms ; IPR001680 [WD40 repeat] -- -- Q8CHI8 E1A-binding protein p400 Ep400 31.5 36.3 44 39.1 38.3 30.5 1.03614457831325 0.789657045084738 0.0512253233551732 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) E1A-binding protein p400 3.6.4.- -- SNF2 family DNA-dependent ATPase R General function prediction only ; IPR000330 [SNF2-related, N-terminal domain] ; IPR001650[Helicase, C-terminal] ; IPR014012[Helicase/SANT-associated domain] ; IPR031575[E1A-binding protein p400, N-terminal] -- -- Q91XU0 ATPase WRNIP1 Wrnip1 100.6 110.4 69.2 64.9 60.9 69.5 1.4347158218126 0.0892910280246256 0.520765006544027 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) putative ATPase -- -- ATPase related to the helicase subunit of the Holliday junction resolvase L Replication, recombination and repair ; IPR003959 [ATPase, AAA-type, core] ; IPR021886[MgsA AAA+ ATPase C-terminal] ; IPR032423[AAA ATPase, C-terminal domain] -- -- Q91W53 Golgin subfamily A member 7 Golga7 253.7 255.9 297 251.2 276.7 271.9 1.00850212553138 0.894898868205851 0.0122141245957471 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019383 [Golgin subfamily A member 7/ERF4] -- -- A0A0U1RNF2 Leucine carboxyl methyltransferase 1 Lcmt1 522.7 492.3 520.9 519 514.8 554.7 0.966887000314762 0.335693713348503 -0.0485808025083297 Nonsignificant None 2 Molecular Function:methyltransferase activity (GO:0008168),Biological Process:methylation (GO:0032259) [phosphatase 2A protein]-leucine-carboxy methyltransferase 2.1.1.233 -- Carboxymethyl transferase O Posttranslational modification, protein turnover, chaperones ; IPR007213 [Methyltransferase Ppm1/Ppm2/Tcmp] -- -- Q3U3W5 Protein arginine N-methyltransferase 9 Prmt9 536 523.1 479.7 448 458.7 475.9 1.11297555330537 0.0508787562407051 0.154421903989435 Nonsignificant None -- -- type II protein arginine methyltransferase 2.1.1.320 -- -- -- -- -- -- -- Q8BXX3 GPI-anchor transamidase Pigk 271.3 263.8 242.3 270.1 294 291.8 0.908283677999766 0.086387112196014 -0.138785139963679 Nonsignificant None 2 Biological Process:proteolysis (GO:0006508),Molecular Function:peptidase activity (GO:0008233) phosphatidylinositol glycan, class K 2.6.-.- ko00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis ko01100 Metabolic pathways Gpi-anchor transamidase O Posttranslational modification, protein turnover, chaperones ; IPR001096 [Peptidase C13, legumain] -- -- Q8BHL4 Retinoic acid-induced protein 3 Gprc5a 681.4 580.2 439.1 476 475.5 459.8 1.20505916530858 0.303169413958924 0.269103980813603 Nonsignificant None 3 Molecular Function:G-protein coupled receptor activity (GO:0004930),Biological Process:G-protein coupled receptor signaling pathway (GO:0007186),Cellular Component:integral component of membrane (GO:0016021) G protein-coupled receptor family C group 5 member A -- -- -- -- -- IPR017978 [GPCR family 3, C-terminal] -- -- E9QLS6 Phosphatidylinositol 3-kinase catalytic subunit type 3 Pik3c3 156.9 155.5 178 202.9 205.7 195.8 0.811383189940437 0.00840173805640303 -0.301544681474048 Nonsignificant None 1 Molecular Function:kinase activity (GO:0016301) phosphatidylinositol 3-kinase 2.7.1.137 ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system ko04136 Autophagy - other ko04140 Autophagy - animal ko04145 Phagosome ko04371 Apelin signaling pathway ko05152 Tuberculosis ko05167 Kaposi's sarcoma-associated herpesvirus infection Phosphatidylinositol 3-kinase VPS34, involved in signal transduction TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR000403 [Phosphatidylinositol 3-/4-kinase, catalytic domain] ; IPR001263[Phosphoinositide 3-kinase, accessory (PIK) domain] ; IPR002420[Phosphatidylinositol 3-kinase, C2 domain] -- -- Q9D7T1 Rab15 effector protein Rep15 499.2 413.6 552 756.7 844.6 837.1 0.600721784776903 0.00273009994935825 -0.735231111695985 Significant down 1 Biological Process:receptor recycling (GO:0001881) Rab15 effector protein -- -- -- -- -- IPR027985 [Rab15 effector] -- -- Q5DU62 MFLJ00139 protein (Fragment) Micall2 60.3 59.8 59.3 63.1 69.4 64.7 0.90973630831643 0.0850574269932872 -0.13647966145865 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:zinc ion binding (GO:0008270) MICAL-like protein 2 -- ko04530 Tight junction -- -- -- IPR001715 [Calponin homology domain] ; IPR001781[Zinc finger, LIM-type] ; IPR022735[Domain of unknown function DUF3585] -- -- F6TLV3 Fibronectin type-III domain-containing protein 3A (Fragment) Fndc3a 952.6 956.1 1022.1 1002.4 1114.9 986 0.944414010891631 0.282928673418912 -0.0825086500023658 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR003961 [Fibronectin type III] -- -- Q6R891 Neurabin-2 Ppp1r9b 192.9 192.8 198.6 183.8 213.8 195.8 0.984664644421975 0.75107983101989 -0.0222956375352284 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) neurabin -- -- Protein phosphatase 1 binding protein spinophilin/neurabin II T Signal transduction mechanisms ; IPR001478 [PDZ domain] -- -- A0A1L1SRN0 6-pyruvoyl tetrahydrobiopterin synthase Pts 521.3 485.4 522.9 591.7 561.2 571.3 0.887136063101728 0.0129083620078961 -0.172772702302482 Nonsignificant None -- -- -- -- ko00790 Folate biosynthesis ko01100 Metabolic pathways 6-pyruvoyl tetrahydrobiopterin synthase H Coenzyme transport and metabolism ; IPR007115 [6-pyruvoyl tetrahydropterin synthase/QueD family protein] -- -- Q99MU3 Double-stranded RNA-specific adenosine deaminase Adar 443.6 414.8 386 344.2 405.4 385 1.09677419354839 0.209482464011126 0.133266530863464 Nonsignificant None 4 Molecular Function:RNA binding (GO:0003723),Molecular Function:double-stranded RNA adenosine deaminase activity (GO:0003726),Molecular Function:adenosine deaminase activity (GO:0004000),Biological Process:RNA processing (GO:0006396) double-stranded RNA-specific adenosine deaminase 3.5.4.37 ko04623 Cytosolic DNA-sensing pathway ko05162 Measles ko05164 Influenza A tRNA-specific adenosine deaminase 1 A RNA processing and modification ; IPR000607 [Double-stranded RNA-specific adenosine deaminase (DRADA)] ; IPR002466[Adenosine deaminase/editase] ; IPR014720[Double-stranded RNA-binding domain] -- -- Q8BTI7 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C Ankrd52 473.9 491.3 415.4 396.1 457.8 419.5 1.08418407413224 0.287657277183371 0.116609720061409 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C -- -- FOG: Ankyrin repeat R General function prediction only ; IPR002110 [Ankyrin repeat] ; IPR020683[Ankyrin repeat-containing domain] -- -- E9Q6H8 Pleckstrin homology domain-containing, family A member 5 Plekha5 329.8 313.9 349.2 377.9 384.4 385.4 0.865121547442711 0.00789320204336159 -0.209025252804219 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR001202 [WW domain] ; IPR001849[Pleckstrin homology domain] -- -- Q91VZ6 Stromal membrane-associated protein 1 Smap1 317.9 312.3 346.7 336.2 359.7 324.8 0.957088272753992 0.37983227305898 -0.063276103518339 Nonsignificant None 1 Molecular Function:GTPase activator activity (GO:0005096) stromal membrane-associated protein -- ko04144 Endocytosis Predicted GTPase-activating protein T Signal transduction mechanisms ; IPR001164 [Arf GTPase activating protein] -- -- Q3TV38 UBC core domain-containing protein Ube2j1 434.2 417 488.5 348.8 411.8 364.7 1.19052697058562 0.0672955762063981 0.251600304261652 Nonsignificant None -- -- ubiquitin-conjugating enzyme E2 J1 2.3.2.23 ko04120 Ubiquitin mediated proteolysis ko04141 Protein processing in endoplasmic reticulum ko05012 Parkinson's disease Non-canonical ubiquitin conjugating enzyme 1 O Posttranslational modification, protein turnover, chaperones ; IPR000608 [Ubiquitin-conjugating enzyme E2] -- -- Q60790 Ras GTPase-activating protein 3 Rasa3 723.1 743.7 674.8 482 489.1 497.8 1.45796174007761 0.00042961780885788 0.54395286086887 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Biological Process:intracellular signal transduction (GO:0035556),Biological Process:regulation of GTPase activity (GO:0043087) Ras GTPase-activating protein 3 -- ko04014 Ras signaling pathway Ras GTPase-activating protein T Signal transduction mechanisms ; IPR000008 [C2 domain] ; IPR001562[Zinc finger, Btk motif] ; IPR001849[Pleckstrin homology domain] ; IPR001936[Ras GTPase-activating protein] -- -- E9Q3U1 Ubiquitin-conjugating enzyme E2 H Ube2h 254.5 261.7 318.4 281.7 250.6 232.6 1.09112302261734 0.401522803155829 0.125813772710124 Nonsignificant None -- -- ubiquitin-conjugating enzyme E2 H 2.3.2.23 ko04120 Ubiquitin mediated proteolysis Ubiquitin-protein ligase O Posttranslational modification, protein turnover, chaperones ; IPR000608 [Ubiquitin-conjugating enzyme E2] -- -- Q3V3N5 Nucleolar GTP-binding protein 2 (Fragment) Gnl2 34.1 31.6 31.6 29.3 33.3 28.3 1.07040704070407 0.287433857883434 0.0981595105870045 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) nuclear GTP-binding protein -- ko03008 Ribosome biogenesis in eukaryotes Nucleolar GTPase R General function prediction only ; IPR006073 [GTP binding domain] ; IPR012971[Nucleolar GTP-binding protein 2, N-terminal domain] -- -- B2KGA7 Protein archease Zbtb8os 572.5 541.9 625.3 610 607.2 598.7 0.958037336857756 0.406751985501058 -0.0618462127778061 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR023572 [Archease domain] -- -- Q3V0H4 Uncharacterized protein Trim24 248.3 210.9 231.1 225.9 215.8 239.6 1.01321003963012 0.826479393098123 0.0189332775172018 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Cellular Component:intracellular (GO:0005622),Molecular Function:zinc ion binding (GO:0008270) tripartite motif-containing protein 24 2.3.2.27 -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR000315 [B-box-type zinc finger] ; IPR001487[Bromodomain] ; IPR019787[Zinc finger, PHD-finger] -- -- A2ARP1 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 Ppip5k1 78.3 80.4 80 91.2 94.4 85.2 0.881462333825702 0.0181529070588513 -0.18202917249322 Nonsignificant None 1 Molecular Function:acid phosphatase activity (GO:0003993) inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase 2.7.4.24 ko04070 Phosphatidylinositol signaling system Arp2/3 complex-interacting protein VIP1/Asp1, involved in regulation of actin cytoskeleton Z Cytoskeleton ; IPR000560 [Histidine phosphatase superfamily, clade-2] -- -- A0A1W6AWH1 Nurim Nrm 179.7 190.7 176.4 178.3 188.8 183.1 0.993820428934933 0.840596256299157 -0.00894289671015077 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q9ESZ9 Elastin (Fragment) 167.5 180.6 144.2 159.4 161 169.6 1.00469387755102 0.948275680501022 0.00675599034493593 Nonsignificant None -- -- elastin -- ko04974 Protein digestion and absorption -- -- -- -- -- -- Q6NVE8 WD repeat-containing protein 44 Wdr44 917.5 868.2 1022.6 1041.9 989.9 935.7 0.946352148272957 0.388414070673579 -0.0795509683722154 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) WD repeat-containing protein 44 -- -- WD40 repeat-containing protein S Function unknown ; IPR001680 [WD40 repeat] -- -- Q8BQ99 Uncharacterized protein Mrps2 141.3 138.9 121.4 149.8 154 189.6 0.813944061613296 0.0957379011318885 -0.296998446349351 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S2 -- ko03010 Ribosome Mitochondrial/chloroplast ribosomal protein S2 J Translation, ribosomal structure and biogenesis ; IPR001865 [Ribosomal protein S2] -- -- E9QP19 E3 ubiquitin-protein ligase TRIM33 Trim33 474.1 404.6 358 413.6 423.4 402.4 0.997821526545102 0.980308028393513 -0.00314630116252361 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Cellular Component:intracellular (GO:0005622),Molecular Function:zinc ion binding (GO:0008270) tripartite motif-containing protein 33 2.3.2.27 -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR000315 [B-box-type zinc finger] ; IPR001487[Bromodomain] ; IPR019787[Zinc finger, PHD-finger] ; IPR027370[RING-type zinc-finger, LisH dimerisation motif] -- -- Q8R322 mRNA export factor GLE1 Gle1 130.4 163.6 175 203.9 221.5 173.1 0.783625730994152 0.0908877134584275 -0.351763324428125 Nonsignificant None 2 Cellular Component:nuclear pore (GO:0005643),Biological Process:poly(A)+ mRNA export from nucleus (GO:0016973) nucleoporin GLE1 -- -- Nuclear-export-signal (NES)-containing protein/polyadenylated-RNA export factor A RNA processing and modification ; IPR012476 [GLE1-like] -- -- V9GXD9 Synergin gamma Synrg 118.9 120.6 136.6 123.7 132.5 138.5 0.952875601722827 0.431185961054832 -0.069640212852797 Nonsignificant None -- -- -- -- -- Synaptic vesicle protein EHS-1 and related EH domain proteins TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; -- -- -- Q8VCK7 Syncollin Sycn 201.5 189.8 197.3 321.2 482.1 428.5 0.477837311251827 0.0447327444743598 -1.06540858588936 Significant down 2 Biological Process:exocytosis (GO:0006887),Cellular Component:secretory granule membrane (GO:0030667) syncollin -- -- -- -- -- IPR028137 [Syncollin] -- -- Q8BV49 Pyrin and HIN domain-containing protein 1 Pyhin1 550.7 594.2 500.9 455.9 496.8 435.9 1.18522252628547 0.0570605947618774 0.245157951468784 Nonsignificant None -- -- -- -- -- -- -- -- IPR004020 [DAPIN domain] ; IPR004021[HIN-200/IF120x] -- -- Q04690 Neurofibromin Nf1 64 73.7 73.1 78.8 71.8 78.4 0.920524017467249 0.192302498242577 -0.119472731347092 Nonsignificant None 1 Biological Process:regulation of GTPase activity (GO:0043087) neurofibromin 1 -- ko01521 EGFR tyrosine kinase inhibitor resistance ko04010 MAPK signaling pathway ko04014 Ras signaling pathway Ras GTPase activating protein RasGAP/neurofibromin V Defense mechanisms ; IPR001251 [CRAL-TRIO lipid binding domain] ; IPR001936[Ras GTPase-activating protein] -- -- Q8C3F2 Constitutive coactivator of PPAR-gamma-like protein 2 Fam120c 78 61.2 67.6 72.1 66.8 75.5 0.96455223880597 0.669621381067565 -0.0520687201428378 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- O35386 Phytanoyl-CoA dioxygenase, peroxisomal Phyh 409.4 463.5 472 472.8 449.7 440.7 0.986575704225352 0.793591457056254 -0.0194983354539936 Nonsignificant None -- -- phytanoyl-CoA hydroxylase 1.14.11.18 ko04146 Peroxisome Peroxisomal phytanoyl-CoA hydroxylase I Lipid transport and metabolism ; IPR008775 [Phytanoyl-CoA dioxygenase] -- -- E9Q5K9 YTH domain-containing protein 1 Ythdc1 563.1 537.3 533.6 534.5 553.5 536.7 1.00572413368622 0.792964513964198 0.00823463363095904 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) YTH domain-containing protein 1 -- -- Putative signal transduction protein involved in RNA splicing TA Signal transduction mechanisms ; RNA processing and modification ; IPR007275 [YTH domain] -- -- A0A0A0MQE8 Rho GTPase-activating protein 21 Arhgap21 353.5 379.2 374.8 465.5 431.1 409.1 0.848204028490465 0.0222759915503643 -0.237516759949461 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Biological Process:signal transduction (GO:0007165) Rho GTPase-activating protein 21/23 -- -- Predicted Rho GTPase-activating protein R General function prediction only ; IPR000198 [Rho GTPase-activating protein domain] ; IPR001478[PDZ domain] -- -- Q6P6M7 O-phosphoseryl-tRNA(Sec) selenium transferase Sepsecs 403.3 398.2 434.9 460.4 452.5 484.2 0.884976021759359 0.0229407872215257 -0.176289728683261 Nonsignificant None 1 Molecular Function:transferase activity (GO:0016740) O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase 2.9.1.2 ko00450 Selenocompound metabolism ko00970 Aminoacyl-tRNA biosynthesis Predicted serine hydroxymethyltransferase SLA/LP (autoimmune hepatitis marker in humans) J Translation, ribosomal structure and biogenesis ; IPR008829 [SepSecS/SepCysS family] -- -- P62322 U6 snRNA-associated Sm-like protein LSm5 Lsm5 102 154.9 121.7 160.4 154.9 153.4 0.807766161723917 0.189065529668839 -0.307990383775319 Nonsignificant None -- -- U6 snRNA-associated Sm-like protein LSm5 -- ko03018 RNA degradation ko03040 Spliceosome U6 snRNA-associated Sm-like protein A RNA processing and modification ; IPR001163 [LSM domain, eukaryotic/archaea-type] -- -- E9Q0A7 Oxidation resistance protein 1 Oxr1 236.3 259.6 229.4 263.8 264.2 279.5 0.898204334365325 0.0593996170122571 -0.154884410899166 Nonsignificant None -- -- -- -- -- Oxidation resistance protein L Replication, recombination and repair ; IPR006571 [TLDc domain] ; IPR018392[LysM domain] -- -- Q7TSH2 Phosphorylase b kinase regulatory subunit beta Phkb 350.1 365.6 375.6 342.5 347.4 360.7 1.03873976775176 0.214220797329721 0.0548342656006752 Nonsignificant None -- -- phosphorylase kinase alpha/beta subunit -- ko04020 Calcium signaling pathway ko04910 Insulin signaling pathway ko04922 Glucagon signaling pathway Phosphorylase kinase G Carbohydrate transport and metabolism ; IPR011613 [Glycoside hydrolase family 15/Phosphorylase b kinase regulatory chain family] -- -- Q9CUB4 NAD(+) kinase (Fragment) Nadk2 271.8 247.6 232.4 261.7 271 279.3 0.925862068965517 0.185027445860619 -0.111130812029522 Nonsignificant None 3 Molecular Function:NAD+ kinase activity (GO:0003951),Biological Process:NADP biosynthetic process (GO:0006741),Biological Process:metabolic process (GO:0008152) NAD+ kinase 2.7.1.23 ko00760 Nicotinate and nicotinamide metabolism ko01100 Metabolic pathways Predicted kinase R General function prediction only ; IPR002504 [NAD kinase] -- -- Q3THA3 Phosphomevalonate kinase Pmvk 1090.3 1083 774.8 733.3 855.1 787.1 1.24104399073879 0.157093140961569 0.311554254949232 Nonsignificant None 3 Molecular Function:phosphomevalonate kinase activity (GO:0004631),Cellular Component:cytoplasm (GO:0005737),Biological Process:cholesterol biosynthetic process (GO:0006695) phosphomevalonate kinase 2.7.4.2 ko00900 Terpenoid backbone biosynthesis ko01100 Metabolic pathways ko04146 Peroxisome -- -- -- IPR005919 [Higher eukaryotic phosphomevalonate kinase] -- -- Q8BTJ4 Bis(5-adenosyl)-triphosphatase enpp4 Enpp4 294.1 274.1 324.8 381 330.1 325.6 0.861387093662583 0.106640863956623 -0.215266387337867 Nonsignificant None 1 Molecular Function:catalytic activity (GO:0003824) ectonucleotide pyrophosphatase/phosphodiesterase family member 4 3.6.1.29 ko00230 Purine metabolism Type I phosphodiesterase/nucleotide pyrophosphatase R General function prediction only ; IPR002591 [Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase] -- -- Q80VP0 Tectonin beta-propeller repeat-containing protein 1 Tecpr1 48.7 44.1 53 64.1 59.1 69.6 0.756224066390041 0.0169362270949135 -0.403114331903025 Nonsignificant None -- -- tectonin beta-propeller repeat-containing protein 1 -- -- Uncharacterized conserved protein, contains dysferlin, TECPR and PH domains R General function prediction only ; IPR006624 [Beta-propeller repeat TECPR] ; IPR010482[Peroxin domain] -- -- Q8BUE4 Ferroptosis suppressor protein 1 Aifm2 157.9 136.4 118.1 160.4 145.4 142.6 0.91971454058876 0.400249684813772 -0.120741945437318 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) -- -- -- Monodehydroascorbate/ferredoxin reductase R General function prediction only ; IPR023753 [FAD/NAD(P)-binding domain] -- -- Q69ZA1 Cyclin-dependent kinase 13 Cdk13 482.5 433.2 325.9 326 335.4 360.8 1.21463510076306 0.197592373107058 0.280522966186918 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) -- -- -- Cdc2-related protein kinase D Cell cycle control, cell division, chromosome partitioning ; IPR000719 [Protein kinase domain] -- -- A2AMS0 Sigma non-opioid intracellular receptor 1 Sigmar1 270.9 281.9 255.2 282.9 314.8 321.9 0.878642888212266 0.0597052584840545 -0.186651173079023 Nonsignificant None -- -- sigma non-opioid intracellular receptor -- -- Sigma receptor and C-8 sterol isomerase T Signal transduction mechanisms ; IPR006716 [ERG2/sigma1 receptor-like] -- -- Q3USC0 Uncharacterized protein Heatr3 200.3 178.3 211.8 193.6 224.3 209.8 0.940576708618767 0.400747355454695 -0.0883824875226844 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- A2A517 Cytohesin-1 (Fragment) Cyth1 59.4 58.1 53.3 62.5 67.9 57.4 0.909478168264111 0.186064969784155 -0.136889088033284 Nonsignificant None 2 Molecular Function:ARF guanyl-nucleotide exchange factor activity (GO:0005086),Biological Process:regulation of ARF protein signal transduction (GO:0032012) cytohesin -- ko04072 Phospholipase D signaling pathway ko04144 Endocytosis Guanine nucleotide exchange factor Cytohesin, contains PH and Sec7 domains U Intracellular trafficking, secretion, and vesicular transport ; IPR000904 [Sec7 domain] ; IPR001849[Pleckstrin homology domain] -- -- A8Y5J3 Integrator complex subunit 11 Ints11 304.5 283.2 255.8 276.6 294.2 280.5 0.990837542581934 0.871414209411304 -0.0132795619200995 Nonsignificant None -- -- integrator complex subunit 11 3.1.27.- -- Predicted cleavage and polyadenylation specificity factor (CPSF subunit) A RNA processing and modification ; IPR001279 [Metallo-beta-lactamase] ; IPR011108[Zn-dependent metallo-hydrolase, RNA specificity domain] ; IPR022712[Beta-Casp domain] -- -- A0A5F8MQ75 Importin-8 (Fragment) Ipo8 30.5 27.7 18.1 17.5 18.8 23.9 1.26744186046512 0.273569400231999 0.341919570074828 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) importin-8 -- -- Nuclear transport receptor RANBP7/RANBP8 (importin beta superfamily) YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; IPR005043 [CAS/CSE, C-terminal] -- -- Q148T0 Williams Beuren syndrome chromosome region 22 Bud23 45 43.6 36.5 36.8 40.5 43.8 1.03303055326177 0.708365562323658 0.0468829244714911 Nonsignificant None 2 Biological Process:metabolic process (GO:0008152),Molecular Function:methyltransferase activity (GO:0008168) 18S rRNA (guanine1575-N7)-methyltransferase 2.1.1.309 -- Predicted protein carboxyl methylase R General function prediction only ; IPR013216 [Methyltransferase type 11] ; IPR022238[Uncharacterised protein family, methyltransferase, Williams-Beuren syndrome] -- -- B7ZMR0 Ubiquitin carboxyl-terminal hydrolase Mindy1 323 416.4 255.8 364.1 465.5 338.9 0.851690201112537 0.394036586052846 -0.231599343539585 Nonsignificant None 2 Molecular Function:thiol-dependent ubiquitin-specific protease activity (GO:0004843),Molecular Function:Lys48-specific deubiquitinase activity (GO:1990380) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR033979 [MINDY deubiquitinase domain] -- -- Q5SVD0 Refilin-B Rflnb 380.6 343.4 340.1 347.2 344.6 369.3 1.00282725473565 0.950592637785288 0.00407311123426977 Nonsignificant None -- -- -- -- -- -- -- -- IPR028215 [FAM101 (Refilin) family] -- -- Q4FZH9 H2-T23 protein H2-T23 154.7 146.1 140.9 130.5 138.9 128 1.11147458480121 0.0469268966082193 0.152474959790483 Nonsignificant None -- -- major histocompatibility complex, class I -- ko04144 Endocytosis ko04145 Phagosome ko04218 Cellular senescence ko04514 Cell adhesion molecules (CAMs) ko04612 Antigen processing and presentation ko04940 Type I diabetes mellitus ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis ko05320 Autoimmune thyroid disease ko05330 Allograft rejection ko05332 Graft-versus-host disease ko05416 Viral myocarditis -- -- -- IPR011161 [MHC class I-like antigen recognition-like] -- -- A0A1G5SK44 Schlafen family member 5 OTTMUSPWKG00059391 46.5 49.8 36.3 50.5 54.1 51.7 0.848368522072937 0.133052587508537 -0.237237002887077 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) -- -- -- -- -- -- IPR007421 [Schlafen, AAA domain] ; IPR018647[Domain of unknown function DUF2075] -- -- I6L960 Ube4a protein Ube4a 686.2 623.6 536.9 555.4 543.9 612.8 1.07861690321827 0.405045905592651 0.109182547896853 Nonsignificant None 4 Cellular Component:ubiquitin ligase complex (GO:0000151),Biological Process:ubiquitin-dependent protein catabolic process (GO:0006511),Biological Process:protein ubiquitination (GO:0016567),Molecular Function:ubiquitin-ubiquitin ligase activity (GO:0034450) ubiquitin conjugation factor E4 A 2.3.2.27 ko04120 Ubiquitin mediated proteolysis Ubiquitin fusion degradation protein-2 O Posttranslational modification, protein turnover, chaperones ; IPR019474 [Ubiquitin conjugation factor E4, core] -- -- Q3TLI6 Uncharacterized protein Ndufaf2 590.5 620.6 549.2 439.4 438.3 340.6 1.44488221291964 0.00956616770614484 0.530951888737772 Nonsignificant None 3 Molecular Function:NADH dehydrogenase (ubiquinone) activity (GO:0008137),Molecular Function:electron carrier activity (GO:0009055),Cellular Component:membrane (GO:0016020) -- -- -- -- -- -- IPR007763 [NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12] -- -- B1AZ46 Brain-specific angiogenesis inhibitor 1-associated protein 2 Baiap2 357.1 299.1 254.7 282.9 256.1 285.3 1.10505883780177 0.405700509880386 0.144123186580491 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Biological Process:plasma membrane organization (GO:0007009) BAI1-associated protein 2 -- ko04520 Adherens junction ko04810 Regulation of actin cytoskeleton -- -- -- IPR001452 [SH3 domain] ; IPR013606[IMD/I-BAR domain] -- -- R4I4W1 Diacylglycerol kinase Dgka 242.8 196.5 241 218.2 230.7 245.4 0.979835805847616 0.79798908569074 -0.0293880823287153 Nonsignificant None 5 Molecular Function:diacylglycerol kinase activity (GO:0004143),Molecular Function:calcium ion binding (GO:0005509),Biological Process:protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205),Molecular Function:kinase activity (GO:0016301),Biological Process:intracellular signal transduction (GO:0035556) diacylglycerol kinase (ATP) 2.7.1.107 ko00561 Glycerolipid metabolism ko00564 Glycerophospholipid metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system ko04072 Phospholipase D signaling pathway ko05231 Choline metabolism in cancer Diacylglycerol kinase IT Lipid transport and metabolism ; Signal transduction mechanisms ; IPR000756 [Diacylglycerol kinase, accessory domain] ; IPR001206[Diacylglycerol kinase, catalytic domain] ; IPR002048[EF-hand domain] ; IPR002219[Protein kinase C-like, phorbol ester/diacylglycerol-binding domain] ; IPR029477[Diacylglycerol kinase type I, N-terminal] -- -- Q3U6I5 C1q domain-containing protein C1qb 338.9 350.5 350 335.6 363 336.5 1.00415418800116 0.890259928302484 0.00598081230206812 Nonsignificant None -- -- complement C1q subcomponent subunit B -- ko04610 Complement and coagulation cascades ko05020 Prion diseases ko05133 Pertussis ko05142 Chagas disease (American trypanosomiasis) ko05150 Staphylococcus aureus infection ko05322 Systemic lupus erythematosus -- -- -- IPR001073 [C1q domain] ; IPR008160[Collagen triple helix repeat] -- -- Q8VBV7 COP9 signalosome complex subunit 8 Cops8 184.4 164.8 162.7 164.5 169.8 179.8 0.995720676911107 0.933348290840234 -0.00618700575894596 Nonsignificant None -- -- COP9 signalosome complex subunit 8 -- -- COP9 signalosome, subunit CSN8 OT Posttranslational modification, protein turnover, chaperones ; Signal transduction mechanisms ; IPR033464 [CSN8/PSMD8/EIF3K] -- -- D3YZG8 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial Mthfd2l 47.7 38.1 40.1 50.7 52.8 39.7 0.879189944134078 0.31344023624198 -0.18575320954524 Nonsignificant None 4 Molecular Function:catalytic activity (GO:0003824),Molecular Function:methylenetetrahydrofolate dehydrogenase (NADP+) activity (GO:0004488),Biological Process:folic acid-containing compound biosynthetic process (GO:0009396),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00670 One carbon pool by folate ko01100 Metabolic pathways Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase H Coenzyme transport and metabolism ; IPR020630 [Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain] ; IPR020631[Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain] -- -- Q505A8 Ribosomal protein L39 Rpl39 355.5 353.7 350 345.6 341.7 303 1.06957487630011 0.232054691124682 0.0970374828635254 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L39e -- ko03010 Ribosome 60s ribosomal protein L39 J Translation, ribosomal structure and biogenesis ; IPR000077 [Ribosomal protein L39e] -- -- Q2M4H7 E3 ubiquitin-protein ligase CBL Cbl 275.4 309.3 263.8 260.7 276.4 271.4 1.04947433518862 0.407321403561072 0.0696668860690017 Nonsignificant None 4 Molecular Function:signal transducer activity (GO:0004871),Molecular Function:calcium ion binding (GO:0005509),Cellular Component:nucleus (GO:0005634),Biological Process:cell surface receptor signaling pathway (GO:0007166) E3 ubiquitin-protein ligase CBL 2.3.2.27 ko04012 ErbB signaling pathway ko04120 Ubiquitin mediated proteolysis ko04144 Endocytosis ko04660 T cell receptor signaling pathway ko04910 Insulin signaling pathway ko05100 Bacterial invasion of epithelial cells ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05220 Chronic myeloid leukemia Tyrosine kinase negative regulator CBL V Defense mechanisms ; IPR003153 [Adaptor protein Cbl, N-terminal helical] ; IPR014741[Adaptor protein Cbl, EF hand-like] ; IPR014742[Adaptor protein Cbl, SH2-like domain] ; IPR015940[Ubiquitin-associated domain] -- -- Q7TSQ8 Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial Pdpr 267.6 256.6 287.9 302.4 306 339 0.857188093730209 0.0382958766057229 -0.222316283645273 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) pyruvate dehydrogenase phosphatase regulatory subunit -- -- Dimethylglycine dehydrogenase precursor E Amino acid transport and metabolism ; IPR006076 [FAD dependent oxidoreductase] ; IPR006222[Glycine cleavage T-protein-like, N-terminal] ; IPR013977[Glycine cleavage T-protein, C-terminal barrel domain] ; IPR032503[FAD dependent oxidoreductase, central domain] -- -- Q8BKU8 Transmembrane protein 87B Tmem87b 518.4 479.1 503.1 550.9 503.6 534.5 0.944367526746381 0.176485986200516 -0.0825796613337551 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) -- -- -- Predicted membrane protein S Function unknown ; IPR009637 [Lung seven transmembrane receptor-like] -- -- B9EJ86 Oxysterol-binding protein-related protein 8 Osbpl8 110.6 95 87.4 76.7 103 104 1.03278110680296 0.796504735622561 0.0465345140352513 Nonsignificant None -- -- oxysterol-binding protein-related protein 8 -- -- Oxysterol-binding protein T Signal transduction mechanisms ; IPR000648 [Oxysterol-binding protein] ; IPR001849[Pleckstrin homology domain] -- -- A2A5G5 WAP four-disulfide core domain protein 2 Wfdc2 100.7 93.6 85.4 161.2 174.4 166.7 0.556838542703564 0.000222178952301479 -0.844669021195638 Significant down 2 Cellular Component:extracellular region (GO:0005576),Molecular Function:peptidase inhibitor activity (GO:0030414) -- -- -- -- -- -- IPR008197 [WAP-type 'four-disulfide core' domain] -- -- Q6P1E1 Zinc finger MIZ domain-containing protein 1 Zmiz1 542.2 516.2 483.8 550.7 548 576.4 0.920661453047579 0.0818859090587168 -0.119257350948183 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) Zn-finger transcription factor K Transcription ; IPR004181 [Zinc finger, MIZ-type] -- zf-MIZ Q8BV66 Interferon-induced protein 44 Ifi44 217.2 222 214.6 199.5 201.3 381.1 0.836168307967771 0.551954720705798 -0.258134730773653 Nonsignificant None -- -- -- -- -- -- -- -- IPR006571 [TLDc domain] -- -- F6SPQ1 Lysosomal thioesterase PPT2 (Fragment) Ppt2 293.2 276.5 289 366.4 365.6 352.5 0.791793453204242 0.000366500361372363 -0.336803956123573 Nonsignificant None 1 Molecular Function:palmitoyl hydrolase activity (GO:0098599) palmitoyl-protein thioesterase 3.1.2.22 ko00062 Fatty acid elongation ko01100 Metabolic pathways ko01212 Fatty acid metabolism ko04142 Lysosome Palmitoyl protein thioesterase IO Lipid transport and metabolism ; Posttranslational modification, protein turnover, chaperones ; IPR000073 [Alpha/beta hydrolase fold-1] ; IPR002472[Palmitoyl protein thioesterase] -- -- Q99PM9 Uridine-cytidine kinase 2 Uck2 446.7 443.5 472.6 393 432.6 423.6 1.09093820044829 0.0664165259379181 0.125569378075773 Nonsignificant None 3 Molecular Function:ATP binding (GO:0005524),Biological Process:metabolic process (GO:0008152),Molecular Function:kinase activity (GO:0016301) uridine kinase 2.7.1.48 ko00240 Pyrimidine metabolism ko00983 Drug metabolism - other enzymes ko01100 Metabolic pathways Armadillo/beta-Catenin/plakoglobin TZ Signal transduction mechanisms ; Cytoskeleton ; IPR006083 [Phosphoribulokinase/uridine kinase] -- -- Q9D6N1 Carbonic anhydrase 13 Ca13 519.7 484.1 767.7 695 668.1 665.8 0.873133224900192 0.437813130514619 -0.195726294138398 Nonsignificant None -- -- carbonic anhydrase 4.2.1.1 ko00910 Nitrogen metabolism Carbonic anhydrase R General function prediction only ; IPR001148 [Alpha carbonic anhydrase] -- -- Q9ESJ0 Exportin-4 Xpo4 139.4 140.4 139.3 125.8 135.1 147.9 1.02519569471624 0.645817012938093 0.0358993251929982 Nonsignificant None -- -- -- -- -- Nuclear transport receptor exportin 4 (importin beta superfamily) YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; IPR014877 [CRM1 C-terminal domain] -- -- P59235 Nucleoporin Nup43 Nup43 606.4 553.9 514.3 519.6 527.9 499.4 1.08255220117655 0.202879491916573 0.114436594063088 Nonsignificant None -- -- nuclear pore complex protein Nup43 -- ko03013 RNA transport Nucleoporin Y Nuclear structure ; -- -- -- Q8BMN7 Guanylate-binding protein 5 Gbp5 85.2 81.1 62.4 60.2 57.4 67.4 1.23621621621622 0.128619975806042 0.305931095007998 Nonsignificant None 2 Molecular Function:GTPase activity (GO:0003924),Molecular Function:GTP binding (GO:0005525) guanylate-binding protein 5 -- ko04621 NOD-like receptor signaling pathway Guanylate-binding protein R General function prediction only ; IPR003191 [Guanylate-binding protein, C-terminal] ; IPR015894[Guanylate-binding protein, N-terminal] -- -- Q9D826 Peroxisomal sarcosine oxidase Pipox 106.9 88 110.7 102 95.1 92.3 1.05597788527989 0.516000167782773 0.0785796215040243 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00260 Glycine, serine and threonine metabolism ko00310 Lysine degradation ko01100 Metabolic pathways ko04146 Peroxisome FAD-dependent oxidoreductase R General function prediction only ; IPR006076 [FAD dependent oxidoreductase] -- -- Q99M50 Phospholipid scramblase Plscr1 77.7 81.2 76.9 62.3 54.3 71.1 1.2562599893447 0.0332546708203997 0.329135068148889 Nonsignificant None -- -- -- -- -- Phospholipid scramblase M Cell wall/membrane/envelope biogenesis ; IPR005552 [Scramblase] -- -- E9Q816 Cytochrome P450 2W1 Cyp2w1 174.9 171.9 223.9 205.4 217.9 211.3 0.899306649858178 0.284197710140531 -0.153114958241187 Nonsignificant None 3 Molecular Function:iron ion binding (GO:0005506),Molecular Function:heme binding (GO:0020037),Biological Process:oxidation-reduction process (GO:0055114) cytochrome P450 family 2 subfamily W polypeptide 1 -- -- Cytochrome P450 CYP2 subfamily Q Secondary metabolites biosynthesis, transport and catabolism ; IPR001128 [Cytochrome P450] -- -- Q9CQ39 Mediator of RNA polymerase II transcription subunit 21 Med21 114.2 107.7 98.1 119.3 117.6 114.9 0.909607731665719 0.0940904976587609 -0.136683577697236 Nonsignificant None -- -- mediator of RNA polymerase II transcription subunit 21 -- -- RNA polymerase II holoenzyme and mediator subcomplex, subunit SURB7/SRB7 K Transcription ; IPR021384 [Mediator complex, subunit Med21] -- -- Q920Q4 Vacuolar protein sorting-associated protein 16 homolog Vps16 244.3 237.6 221.2 196.6 205.5 219.9 1.13038585209003 0.0487725409161403 0.176815314125536 Nonsignificant None 2 Cellular Component:cytoplasm (GO:0005737),Biological Process:intracellular protein transport (GO:0006886) vacuolar protein sorting-associated protein 16 -- Vacuolar assembly/sorting protein VPS16 U Intracellular trafficking, secretion, and vesicular transport ; IPR006925 [Vps16, C-terminal] ; IPR006926[Vps16, N-terminal] -- -- Q3UBK1 MRG domain-containing protein Morf4l1 706.4 594.3 598.7 513.1 528.3 550.9 1.19286566601771 0.055504419177558 0.254431583785718 Nonsignificant None -- -- mortality factor 4-like protein 1 -- -- Dosage compensation regulatory complex/histone acetyltransferase complex, subunit MSL-3/MRG15/EAF3, and related CHROMO domain-containing proteins BK Chromatin structure and dynamics ; Transcription ; IPR025995 [RNA binding activity-knot of a chromodomain] ; IPR026541[MRG domain] -- -- E0CXR8 Partitioning defective 3 homolog (Fragment) Pard3 441.4 392.8 339.9 354.1 348.9 404.6 1.06003972553268 0.553013589776508 0.0841183315385599 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) partitioning defective protein 3 -- ko04015 Rap1 signaling pathway ko04062 Chemokine signaling pathway ko04080 Neuroactive ligand-receptor interaction ko04144 Endocytosis ko04360 Axon guidance ko04390 Hippo signaling pathway ko04520 Adherens junction ko04530 Tight junction ko05165 Human papillomavirus infection FOG: PDZ domain S Function unknown ; IPR001478 [PDZ domain] ; IPR021922[Domain of unknown function DUF3534] -- -- Q9CQ02 COMM domain-containing protein 4 Commd4 364.8 412.3 366.8 369 384 391.7 0.999301126932821 0.98815373059039 -0.00100861319559582 Nonsignificant None -- -- -- -- -- IPR017920 [COMM domain] -- -- A0A0G2JEC8 (Lyso)-N-acylphosphatidylethanolamine lipase (Fragment) Abhd4 66.5 80.9 67 83.2 80.2 68.2 0.92573402417962 0.43260961171121 -0.111330347531464 Nonsignificant None -- -- abhydrolase domain-containing protein 4 -- -- Predicted hydrolase/acyltransferase (alpha/beta hydrolase superfamily) R General function prediction only ; IPR000073 [Alpha/beta hydrolase fold-1] -- -- Q8JZL3 Thiamine-triphosphatase Thtpa 234.3 231.6 233.5 217.4 276 252.2 0.938036480686695 0.461022281739097 -0.092284063956564 Nonsignificant None -- -- thiamine-triphosphatase 3.6.1.28 ko00730 Thiamine metabolism ko01100 Metabolic pathways -- -- -- IPR023577 [CYTH domain] -- -- Q9D2R8 28S ribosomal protein S33, mitochondrial Mrps33 601 562.2 708.9 747.1 737.3 670.2 0.86888517590272 0.133348809233019 -0.202762558930606 Nonsignificant None -- -- small subunit ribosomal protein S33 -- -- Ganglioside-induced differentiation associated protein 3 T Signal transduction mechanisms ; IPR013219 [Ribosomal protein S27/S33, mitochondrial] -- -- A0A6I8MX12 RNA-binding motif, single-stranded-interacting protein 3 Rbms3 365.5 374.4 361.3 331.3 343.2 323.6 1.10329626289951 0.00753958702176188 0.141820242991539 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- FOG: RRM domain R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- Q8BPG6 Inactive C-alpha-formylglycine-generating enzyme 2 Sumf2 291.6 277.4 204.1 193.6 189.3 188.1 1.35394045534151 0.130373011260599 0.437164292330571 Nonsignificant None -- -- -- -- -- -- -- -- IPR005532 [Sulfatase-modifying factor enzyme] -- -- Q8VED9 Galectin-related protein Lgalsl 272.5 254.1 284.4 334.6 336 328.8 0.811486892135281 0.00229795124795471 -0.301360303631253 Nonsignificant None 1 Molecular Function:carbohydrate binding (GO:0030246) -- -- -- Galectin, galactose-binding lectin W Extracellular structures ; IPR001079 [Galectin, carbohydrate recognition domain] -- -- P63271 Transcription elongation factor SPT4-A Supt4h1a 345.2 353.1 312.4 312 311 286.2 1.11163660360757 0.0878167589244568 0.152685245025066 Nonsignificant None -- -- transcription elongation factor SPT4 -- -- Transcription elongation factor SPT4 K Transcription ; IPR022800 [Spt4/RpoE2 zinc finger] -- -- F6YTG0 Enoyl-CoA hydratase domain-containing protein 2, mitochondrial (Fragment) Echdc2 183.5 143.8 191.8 195.4 201.7 205.1 0.862005978080372 0.140142811374691 -0.214230220332849 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) -- -- -- Enoyl-CoA hydratase I Lipid transport and metabolism ; IPR001753 [Crotonase superfamily] -- -- Q5BKS1 Solute carrier family 4 (Anion exchanger), member 1, adaptor protein Slc4a1ap 152 149.3 133.5 134.9 182 153.7 0.923926901827454 0.466802690814982 -0.114149380196988 Nonsignificant None -- -- -- -- -- Anion exchanger adaptor protein Kanadaptin, contains FHA domain R General function prediction only ; IPR014720 [Double-stranded RNA-binding domain] -- -- H9KV04 Mini-chromosome maintenance complex-binding protein Mcmbp 281.9 283.8 266.8 274.4 286.3 311.2 0.954811331574722 0.3388721395797 -0.066712406651954 Nonsignificant None -- -- -- -- -- Conserved membrane protein S Function unknown ; IPR019140 [Mini-chromosome maintenance complex-binding protein] -- -- D3YXD1 Ubiquitin-conjugating enzyme E2 E2 (Fragment) Ube2e2 104.9 103.8 232.2 204.1 164.5 172.6 0.814671101256467 0.492392974544983 -0.29571036236079 Nonsignificant None -- -- ubiquitin-conjugating enzyme E2 E 2.3.2.23 ko04120 Ubiquitin mediated proteolysis Ubiquitin-protein ligase O Posttranslational modification, protein turnover, chaperones ; IPR000608 [Ubiquitin-conjugating enzyme E2] -- -- E9Q496 Vesicle transport protein USE1 Use1 460.3 433.8 392.6 368.8 373.5 398.9 1.12749737118822 0.0901580038293944 0.173124069774993 Nonsignificant None -- -- unconventional SNARE in the endoplasmic reticulum protein 1 -- ko04130 SNARE interactions in vesicular transport Predicted membrane protein S Function unknown ; IPR019150 [Vesicle transport protein, Use1] -- -- Q8K357 Procr protein Procr 538.1 571.7 582.2 529.8 580.5 529 1.03214786799244 0.461929000526909 0.0456496695380002 Nonsignificant None -- -- protein C receptor, endothelial (EPCR) -- ko04610 Complement and coagulation cascades -- -- -- IPR011161 [MHC class I-like antigen recognition-like] -- -- Q91YD3 mRNA-decapping enzyme 1A Dcp1a 217 210.9 212.9 192.9 182.2 183.1 1.14797563597277 0.00205940371960085 0.199092023342643 Nonsignificant None 3 Biological Process:deadenylation-dependent decapping of nuclear-transcribed mRNA (GO:0000290),Molecular Function:enzyme activator activity (GO:0008047),Biological Process:positive regulation of catalytic activity (GO:0043085) mRNA-decapping enzyme 1A 3.-.-.- ko03018 RNA degradation Decapping enzyme complex component DCP1 KA Transcription ; RNA processing and modification ; IPR010334 [mRNA-decapping enzyme subunit 1] ; IPR031953[mRNA-decapping enzyme, C-terminal] -- -- P70207 Plexin-A2 Plxna2 86.3 77.5 60.7 92.6 75.6 77.1 0.915205870362821 0.496043427965842 -0.127831788929093 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:membrane (GO:0016020) plexin A -- ko04360 Axon guidance Plexins (functional semaphorin receptors) T Signal transduction mechanisms ; IPR001627 [Sema domain] ; IPR002165[Plexin repeat] ; IPR002909[IPT domain] ; IPR013548[Plexin, cytoplasmic RasGAP domain] -- -- Q91ZJ7 Sodium/calcium exchanger 1 (Fragment) Slc8a1 34.1 30.1 47.5 36.2 31.3 35 1.08975609756098 0.604601561720001 0.124005276090506 Nonsignificant None 3 Biological Process:cell communication (GO:0007154),Cellular Component:integral component of membrane (GO:0016021),Biological Process:transmembrane transport (GO:0055085) solute carrier family 8 (sodium/calcium exchanger) -- ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04371 Apelin signaling pathway ko04740 Olfactory transduction ko04974 Protein digestion and absorption Ca2+/Na+ exchanger NCX1 and related proteins PT Inorganic ion transport and metabolism ; Signal transduction mechanisms ; IPR003644 [Na-Ca exchanger/integrin-beta4] ; IPR004837[Sodium/calcium exchanger membrane region] ; IPR032452[Sodium/calcium exchanger domain, C-terminal extension] -- -- A0A140LIS5 Arginine and glutamate-rich protein 1 (Fragment) Arglu1 1037.9 1021 1147.4 1042.9 988.3 962.9 1.07087271634214 0.199851054620713 0.0987870119138031 Nonsignificant None -- -- arginine and glutamate-rich protein 1 -- -- -- -- -- IPR033371 [Arginine and glutamate-rich protein 1] -- -- Q0VBL3 RNA-binding protein 15 Rbm15 771.2 761.4 920.4 807 848.1 829.3 0.987361133472871 0.852525421450951 -0.018350239001742 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) RNA-binding protein 15 -- -- Large RNA-binding protein (RRM superfamily) R General function prediction only ; IPR000504 [RNA recognition motif domain] ; IPR012921[Spen paralogue and orthologue SPOC, C-terminal] -- -- A0A286YE31 Ubiquitin-conjugating enzyme E2 E1 (Fragment) Ube2e1 85.5 84 102.5 77.3 84.8 90.8 1.07552392249901 0.420707618455877 0.105039614474464 Nonsignificant None -- -- ubiquitin-conjugating enzyme E2 E 2.3.2.23 ko04120 Ubiquitin mediated proteolysis Ubiquitin-protein ligase O Posttranslational modification, protein turnover, chaperones ; IPR000608 [Ubiquitin-conjugating enzyme E2] -- -- Q8K0U2 Pak4 protein (Fragment) Pak4 467.3 447.4 466 422.1 412.5 430.7 1.09120366711452 0.00978759866325276 0.125920397824284 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) p21-activated kinase 4 2.7.11.1 ko04012 ErbB signaling pathway ko04014 Ras signaling pathway ko04360 Axon guidance ko04510 Focal adhesion ko04660 T cell receptor signaling pathway ko04810 Regulation of actin cytoskeleton ko05206 MicroRNAs in cancer ko05211 Renal cell carcinoma p21-activated serine/threonine protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q9QYS9 Protein quaking Qki 1056.7 1053.3 984.4 883.3 867 862.4 1.18436866077238 0.00275747885002726 0.244118221407867 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) protein quaking -- -- RNA-binding protein Sam68 and related KH domain proteins A RNA processing and modification ; IPR004088 [K Homology domain, type 1] ; IPR032367[Protein quaking, putative nuclear localisation signal] ; IPR032377[STAR protein, homodimerisation region] -- -- Q3TTV6 Tuftelin-interacting protein 11 Tfip11 164.5 160.8 112.4 130.5 133.2 149.8 1.05852478839178 0.67451175962868 0.0820550545804099 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634) tuftelin-interacting protein 11 -- -- Tuftelin-interacting protein TIP39, contains G-patch domain A RNA processing and modification ; IPR000467 [G-patch domain] ; IPR022159[Tuftelin interacting protein, N-terminal domain] ; IPR022783[GC-rich sequence DNA-binding factor domain] -- -- Q5U4C3 Splicing factor, arginine/serine-rich 19 Scaf1 706.2 680.6 474.8 422.9 414.4 485.2 1.4076370510397 0.0787724327407169 0.493275393516598 Nonsignificant None -- -- -- -- -- PHD Zn-finger protein R General function prediction only ; -- -- -- A2AEM2 Chloride channel CLIC-like protein 1 Clcc1 208.5 192.8 182.4 185.4 179 192.1 1.04887690925427 0.345040111308185 0.0688453806529174 Nonsignificant None -- -- chloride channel CLIC-like protein 1 -- -- -- -- -- IPR009231 [Chloride channel CLIC-like] -- -- E9PYD1 Family with sequence similarity 98, member C Fam98c 20.3 15.3 26.1 31.5 38.3 31.6 0.608481262327416 0.0263006723790206 -0.716715257853923 Significant down -- -- -- -- -- Uncharacterized conserved glycine-rich protein S Function unknown ; IPR018797 [Uncharacterised protein family FAM98] -- -- D3Z325 Tumor necrosis factor alpha-induced protein 8 Tnfaip8 981.3 1012.2 981.1 887.8 882.3 891.5 1.11759843703036 0.000613737931485815 0.160401908241788 Nonsignificant None -- -- -- -- -- -- -- -- IPR008477 [Protein of unknown function DUF758] -- -- Q8R4E5 Upstream transcription factor 1 short form Usf1 83.1 81.4 69 69 85.2 96.5 0.931392102114081 0.564270895888013 -0.102539446236915 Nonsignificant None 1 Molecular Function:protein dimerization activity (GO:0046983) upstream stimulatory factor -- -- Helix loop helix transcription factor EB K Transcription ; IPR011598 [Myc-type, basic helix-loop-helix (bHLH) domain] -- bHLH Q9CQS2 H/ACA ribonucleoprotein complex subunit 3 Nop10 294.3 248.5 223.9 256.6 262.4 269.4 0.972475900558092 0.747365251055376 -0.0402655965377655 Nonsignificant None 3 Biological Process:pseudouridine synthesis (GO:0001522),Molecular Function:snoRNA binding (GO:0030515),Biological Process:ribosome biogenesis (GO:0042254) H/ACA ribonucleoprotein complex subunit 3 -- ko03008 Ribosome biogenesis in eukaryotes H/ACA snoRNP complex, subunit NOP10 A RNA processing and modification ; IPR007264 [H/ACA ribonucleoprotein complex, subunit Nop10] -- -- A0A0J9YTU3 Cytospin-B Specc1 151 126 133.8 158.3 173 156.8 0.841630813357918 0.0459947135636004 -0.248740570075489 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- FOG: Calponin homology domain R General function prediction only ; IPR001715 [Calponin homology domain] -- -- Q9CR13 Protein FMC1 homolog Fmc1 307.1 333.1 454.7 414.2 403 351.3 0.937013264869491 0.645785862480393 -0.0938586232825439 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- E9Q6J5 Biorientation of chromosomes in cell division protein 1-like 1 Bod1l 64.8 67.8 78.3 89.8 86.1 77.2 0.833267483208218 0.0641526544158764 -0.263148412316993 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q3TIW4 FERM domain-containing protein Nf2 228 225 223.1 204.7 226.9 232 1.01883664858348 0.649698732091715 0.0269227608561685 Nonsignificant None 3 Cellular Component:cytoplasm (GO:0005737),Molecular Function:cytoskeletal protein binding (GO:0008092),Cellular Component:extrinsic component of membrane (GO:0019898) merlin -- ko04390 Hippo signaling pathway ko04392 Hippo signaling pathway - multiple species ko04530 Tight junction Radixin, moesin and related proteins of the ERM family R General function prediction only ; IPR011259 [Ezrin/radixin/moesin, C-terminal] ; IPR018980[FERM, C-terminal PH-like domain] ; IPR019748[FERM central domain] -- -- Q8R1R2 Ubac2 protein (Fragment) Ubac2 272.2 277.9 277 265.6 287.4 272.5 1.00193821926105 0.940124636106595 0.00279355293072628 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR015940 [Ubiquitin-associated domain] -- -- Q8K273 ER membrane protein complex subunit 5 Mmgt1 238.8 231.5 245.9 296.5 290 266.1 0.840018766127141 0.0109359334791465 -0.251506536643412 Nonsignificant None -- -- -- -- -- Predicted membrane protein S Function unknown ; IPR018937 [Magnesium transporter] -- -- Q9R0M5 Thiamin pyrophosphokinase 1 Tpk1 165.4 147.8 243.4 259.5 252.6 273.6 0.708412880234186 0.0637135596277588 -0.497337651740145 Nonsignificant None 4 Molecular Function:thiamine diphosphokinase activity (GO:0004788),Molecular Function:ATP binding (GO:0005524),Biological Process:thiamine diphosphate biosynthetic process (GO:0009229),Molecular Function:thiamine binding (GO:0030975) thiamine pyrophosphokinase 2.7.6.2 ko00730 Thiamine metabolism ko01100 Metabolic pathways Thiamine pyrophosphokinase H Coenzyme transport and metabolism ; IPR007371 [Thiamin pyrophosphokinase, catalytic domain] ; IPR007373[Thiamin pyrophosphokinase, vitamin B1-binding domain] -- -- P62309 Small nuclear ribonucleoprotein G Snrpg 764.8 786.4 711.6 671.2 704.7 614.4 1.13691403306034 0.0579005284201515 0.185123170002894 Nonsignificant None -- -- small nuclear ribonucleoprotein G -- ko03040 Spliceosome Small Nuclear ribonucleoprotein G A RNA processing and modification ; IPR001163 [LSM domain, eukaryotic/archaea-type] -- -- Q9ERV1 E3 ubiquitin-protein ligase makorin-2 Mkrn2 568 575.5 509.1 536.3 517.8 530.6 1.0428472266044 0.35575371787182 0.0605278236642746 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) E3 ubiquitin-protein ligase makorin 2.3.2.27 -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR000571 [Zinc finger, CCCH-type] ; IPR018957[Zinc finger, C3HC4 RING-type] -- -- Q9ET26 E3 ubiquitin-protein ligase RNF114 Rnf114 709.9 749.3 718.8 699.7 719.1 650.9 1.05232642411944 0.199852843023816 0.0735822877206701 Nonsignificant None -- -- RING finger protein 114 2.3.2.27 -- -- -- -- IPR008598 [Drought induced 19 protein type, zinc-binding domain] ; IPR027370[RING-type zinc-finger, LisH dimerisation motif] -- -- Q9CY34 NEDD8-conjugating enzyme UBE2F Ube2f 196.6 226.1 194.3 268.7 244.7 211.7 0.850917114880706 0.137384368295745 -0.232909484449959 Nonsignificant None -- -- ubiquitin-conjugating enzyme E2 F 2.3.2.23 ko04120 Ubiquitin mediated proteolysis Ubiquitin-protein ligase O Posttranslational modification, protein turnover, chaperones ; IPR000608 [Ubiquitin-conjugating enzyme E2] -- -- E9Q3V2 UDP-N-acetylglucosamine transporter (Fragment) Slc35a3 357.8 313.8 309.1 369.6 363.6 427.5 0.844921168260532 0.0790957239230292 -0.24311135167595 Nonsignificant None 4 Cellular Component:Golgi membrane (GO:0000139),Molecular Function:sugar:proton symporter activity (GO:0005351),Biological Process:carbohydrate transport (GO:0008643),Cellular Component:integral component of membrane (GO:0016021) solute carrier family 35 (UDP-sugar transporter), member A1/2/3 -- -- Predicted UDP-galactose transporter G Carbohydrate transport and metabolism ; IPR007271 [Nucleotide-sugar transporter] -- -- Q8BPC1 Tyrosine-protein kinase 474 436 537.1 508.8 515.8 541.2 0.924192106271554 0.271992984151222 -0.113735327706565 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein binding (GO:0005515),Biological Process:protein phosphorylation (GO:0006468) fyn-related kinase 2.7.10.2 Tyrosine kinases T Signal transduction mechanisms ; IPR000980 [SH2 domain] ; IPR001245[Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR001452[SH3 domain] -- -- Q8C6H6 Endo/exonuclease/phosphatase domain-containing protein Smpd2 457.3 440.8 376.7 441 396 432.6 1.00409577819786 0.953934097834194 0.00589689094267132 Nonsignificant None -- -- sphingomyelin phosphodiesterase 2 3.1.4.12 ko00600 Sphingolipid metabolism ko01100 Metabolic pathways ko04071 Sphingolipid signaling pathway Sphingomyelinase family protein T Signal transduction mechanisms ; IPR005135 [Endonuclease/exonuclease/phosphatase] -- -- A2RS96 Transmembrane emp24 domain-containing protein 5 Tmed5 519.7 546.5 653.9 588.8 697.9 576.2 0.923345321810081 0.445754021916336 -0.115057792745967 Nonsignificant None 2 Biological Process:transport (GO:0006810),Cellular Component:integral component of membrane (GO:0016021) p24 family protein gamma-2 -- -- Membrane trafficking protein, emp24/gp25L/p24 family U Intracellular trafficking, secretion, and vesicular transport ; IPR009038 [GOLD domain] -- -- Q3UDQ8 Uncharacterized protein Slc12a4 25 40.2 15.9 49 32.4 27.1 0.747465437788019 0.398957472784606 -0.419921223114568 Nonsignificant None 5 Molecular Function:transporter activity (GO:0005215),Biological Process:transport (GO:0006810),Biological Process:ion transport (GO:0006811),Cellular Component:membrane (GO:0016020),Biological Process:transmembrane transport (GO:0055085) solute carrier family 12 (potassium/chloride transporter), member 4/5/6 -- -- K+/Cl- cotransporter KCC1 and related transporters P Inorganic ion transport and metabolism ; IPR004841 [Amino acid permease/ SLC12A domain] ; IPR018491[SLC12A transporter, C-terminal] -- -- Q3THK0 DNA primase large subunit Prim2 102.9 105 129.7 120.5 124.6 105.4 0.963195435092725 0.700425141610154 -0.0540995401908004 Nonsignificant None 1 Molecular Function:DNA primase activity (GO:0003896) DNA primase large subunit 2.7.7.- ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways ko03030 DNA replication Eukaryotic-type DNA primase, large subunit L Replication, recombination and repair ; IPR007238 [DNA primase large subunit, eukaryotic/archaeal] -- -- Q3V1T4 Prolyl 3-hydroxylase 1 P3h1 696.4 665.1 655.8 634.4 626.9 609.4 1.07836638691399 0.0270910793120166 0.108847432986018 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) leucine proline-enriched proteoglycan (leprecan) -- -- Membrane-associated proteoglycan Leprecan S Function unknown ; IPR005123 [Oxoglutarate/iron-dependent dioxygenase] -- -- E9Q4X2 UDP-glucose glycoprotein glucosyltransferase 2 Uggt2 69.6 70.9 99.2 72.1 83.2 77.1 1.03141135972461 0.822772571861574 0.0446198402446042 Nonsignificant None 2 Molecular Function:UDP-glucose:glycoprotein glucosyltransferase activity (GO:0003980),Biological Process:protein glycosylation (GO:0006486) UDP-glucose:glycoprotein glucosyltransferase 2.4.1.- ko04141 Protein processing in endoplasmic reticulum UDP-glucose:glycoprotein glucosyltransferase G Carbohydrate transport and metabolism ; IPR009448 [UDP-glucose:Glycoprotein Glucosyltransferase] -- -- Q6PDY2 2-aminoethanethiol dioxygenase Ado 393.4 404.8 406.6 456.5 452.1 423.3 0.904572415346497 0.0193977770019225 -0.144692092782281 Nonsignificant None 1 Biological Process:oxidation-reduction process (GO:0055114) cysteamine dioxygenase 1.13.11.19 ko00430 Taurine and hypotaurine metabolism ko01100 Metabolic pathways Uncharacterized conserved protein S Function unknown ; IPR012864 [Cysteine oxygenase/2-aminoethanethiol dioxygenase] -- -- Q5HZI9 Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51 Slc25a51 577.2 574.2 597.3 586 588.8 634 0.966773551525874 0.307920673878654 -0.0487500897238721 Nonsignificant None -- -- -- -- -- Predicted mitochondrial carrier protein R General function prediction only ; IPR018108 [Mitochondrial substrate/solute carrier] -- -- Q9Z2E3 Serine/threonine-protein kinase/endoribonuclease IRE2 Ern2 176.4 163.1 165.7 215.7 182.2 219.3 0.818535320803629 0.0404130063840012 -0.288883422783183 Nonsignificant None 5 Molecular Function:ribonuclease activity (GO:0004540),Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:mRNA processing (GO:0006397),Biological Process:protein phosphorylation (GO:0006468) -- -- -- Serine/threonine protein kinase and endoribonuclease ERN1/IRE1, sensor of the unfolded protein response pathway T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR010513[KEN domain] -- -- P17809 Solute carrier family 2, facilitated glucose transporter member 1 Slc2a1 614.3 625.1 495.7 403.8 395.4 372.2 1.48121905412327 0.0115136301855773 0.566785013299161 Nonsignificant None 3 Cellular Component:integral component of membrane (GO:0016021),Molecular Function:transmembrane transporter activity (GO:0022857),Biological Process:transmembrane transport (GO:0055085) MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1 -- ko04066 HIF-1 signaling pathway ko04911 Insulin secretion ko04919 Thyroid hormone signaling pathway ko04920 Adipocytokine signaling pathway ko04922 Glucagon signaling pathway ko04931 Insulin resistance ko04976 Bile secretion ko05166 HTLV-I infection ko05200 Pathways in cancer ko05211 Renal cell carcinoma ko05230 Central carbon metabolism in cancer Permease of the major facilitator superfamily G Carbohydrate transport and metabolism ; IPR005828 [Major facilitator, sugar transporter-like] -- -- Q9CX60 Protein LBH Lbh 70 75.3 71.2 80.2 76.7 93.4 0.864962045545346 0.102135474165241 -0.209291266074245 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q9Z255 Ubiquitin-conjugating enzyme E2 A Ube2a 354 304.1 303.1 320.1 311.9 334.2 0.994825087973505 0.930757115137629 -0.00748520430221045 Nonsignificant None -- -- ubiquitin-conjugating enzyme E2 A 2.3.2.23 ko04120 Ubiquitin mediated proteolysis Ubiquitin-protein ligase O Posttranslational modification, protein turnover, chaperones ; IPR000608 [Ubiquitin-conjugating enzyme E2] -- -- Q8C3P7 N6-adenosine-methyltransferase subunit METTL3 Mettl3 26.7 23.8 35.2 25.6 36.8 27.2 0.956473214285714 0.803576072720812 -0.0642035279451043 Nonsignificant None 2 Biological Process:nucleobase-containing compound metabolic process (GO:0006139),Molecular Function:methyltransferase activity (GO:0008168) mRNA (2'-O-methyladenosine-N6-)-methyltransferase 2.1.1.62 -- Predicted N6-adenine RNA methylase A RNA processing and modification ; IPR007757 [MT-A70-like] -- -- D3YUL8 Phosphatidylinositol-3,4-bisphosphate 4-phosphatase Inpp4a 32.3 32.1 41.5 33.2 43.6 39.3 0.912144702842377 0.47587080940708 -0.13266538287323 Nonsignificant None -- -- inositol polyphosphate-4-phosphatase 3.1.3.66 ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system Inositol-polyphosphate 4-phosphatase T Signal transduction mechanisms ; -- -- -- Q9CZH7 Matrix-remodeling-associated protein 7 Mxra7 10.9 16.6 14.3 14.4 18.2 18.9 0.811650485436893 0.209943010798165 -0.301069489989698 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q924N4 Solute carrier family 12 member 6 Slc12a6 19.6 18.8 13.2 19.3 24.3 20.3 0.807511737089202 0.180046571017656 -0.308444865523741 Nonsignificant None 5 Molecular Function:transporter activity (GO:0005215),Biological Process:transport (GO:0006810),Biological Process:ion transport (GO:0006811),Cellular Component:membrane (GO:0016020),Biological Process:transmembrane transport (GO:0055085) solute carrier family 12 (potassium/chloride transporter), member 4/5/6 -- -- K+/Cl- cotransporter KCC1 and related transporters P Inorganic ion transport and metabolism ; IPR004841 [Amino acid permease/ SLC12A domain] ; IPR018491[SLC12A transporter, C-terminal] -- -- Q9CPS7 RNA-binding protein PNO1 Pno1 114.1 106.7 100 67 81.5 80.4 1.40148536478812 0.00776344608897899 0.486956678899234 Nonsignificant None -- -- RNA-binding protein PNO1 -- -- Predicted RNA-binding protein Pno1p interacting with Nob1p and involved in 26S proteasome assembly O Posttranslational modification, protein turnover, chaperones ; -- -- -- Q05CA9 Prcc protein (Fragment) Prcc 99.1 103.7 94.5 82 93.8 97.9 1.08622579466569 0.222801604043622 0.119324028542688 Nonsignificant None -- -- proline-rich protein PRCC -- ko05202 Transcriptional misregulation in cancer ko05211 Renal cell carcinoma Mitotic checkpoint protein PRCC D Cell cycle control, cell division, chromosome partitioning ; IPR018800 [Proline-rich protein PRCC] -- -- H3BK33 Mediator of RNA polymerase II transcription subunit 23 (Fragment) Med23 47.2 42.4 36 45.2 36.4 37.2 1.05723905723906 0.6253293917886 0.0803016280908613 Nonsignificant None -- -- mediator of RNA polymerase II transcription subunit 23 -- -- Cofactor required for Sp1 transcriptional activation, subunit 3 K Transcription ; IPR021629 [Mediator complex, subunit Med23] -- -- O54824 Pro-interleukin-16 Il16 260.7 237.8 233.8 238.9 240.7 241.4 1.01567267683773 0.697575020230783 0.0224355363741252 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR001478 [PDZ domain] -- -- Q91WK7 Ankyrin repeat domain-containing protein 54 Ankrd54 167.5 166.1 168.1 190.5 187.1 204.1 0.86247206463813 0.0344493842544586 -0.213450366063652 Nonsignificant None -- -- ankyrin repeat domain-containing protein 54 -- -- FOG: Ankyrin repeat R General function prediction only ; -- -- -- Q9CQA5 Mediator of RNA polymerase II transcription subunit 4 Med4 33.1 30.6 31 26.9 33.3 24.2 1.12203791469194 0.288488243242076 0.1661214267612 Nonsignificant None 3 Molecular Function:RNA polymerase II transcription cofactor activity (GO:0001104),Biological Process:regulation of transcription from RNA polymerase II promoter (GO:0006357),Cellular Component:mediator complex (GO:0016592) mediator of RNA polymerase II transcription subunit 4 -- ko04919 Thyroid hormone signaling pathway Vitamin-D-receptor interacting protein complex component K Transcription ; IPR019258 [Mediator complex, subunit Med4] -- -- Q99J10 Cytoplasmic tRNA 2-thiolation protein 1 Ctu1 236.9 218.1 190.1 212.5 218.2 214.3 1.00015503875969 0.998273766206154 0.000223656312499385 Nonsignificant None -- -- cytoplasmic tRNA 2-thiolation protein 1 2.7.7.- ko04122 Sulfur relay system Uncharacterized conserved protein with similarity to predicted ATPase of the PP-loop superfamily R General function prediction only ; IPR011063 [tRNA(Ile)-lysidine/2-thiocytidine synthase, N-terminal] ; IPR032442[Cytoplasmic tRNA 2-thiolation protein 1, C-terminal] -- -- Q9DCI9 39S ribosomal protein L32, mitochondrial Mrpl32 574.7 557.2 627 578.4 599.5 632 0.97182164760484 0.550758352073233 -0.0412365256300347 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Biological Process:translation (GO:0006412),Cellular Component:large ribosomal subunit (GO:0015934) large subunit ribosomal protein L32 -- ko03010 Ribosome Mitochondrial ribosomal protein L32 J Translation, ribosomal structure and biogenesis ; IPR002677 [Ribosomal protein L32p] -- -- D3YWK1 WD repeat domain phosphoinositide-interacting protein 2 Wipi2 296.4 284.3 283.3 295.3 305.6 298.6 0.96053362979433 0.0848171915893065 -0.0580919690880138 Nonsignificant None -- -- autophagy-related protein 18 -- ko04136 Autophagy - other ko04140 Autophagy - animal Uncharacterized conserved protein, contains WD40 repeats S Function unknown ; -- -- -- A0A494BAM2 RNA 3-terminal phosphate cyclase-like protein Rcl1 614.4 583.4 572 495.2 473.1 509.2 1.19783417935702 0.00407895720566499 0.260428204306005 Nonsignificant None -- -- RNA 3'-terminal phosphate cyclase-like protein -- ko03008 Ribosome biogenesis in eukaryotes RNA 3'-terminal phosphate cyclase A RNA processing and modification ; IPR013791 [RNA 3'-terminal phosphate cyclase, insert domain] ; IPR023797[RNA 3'-terminal phosphate cyclase domain] -- -- Q8K072 Receptor expression-enhancing protein 4 Reep4 136 134.4 139.3 148.6 160.8 129.7 0.933044864495559 0.392083995411804 -0.0999816416462406 Nonsignificant None -- -- receptor expression-enhancing protein 1/2/3/4 -- -- HVA22/DP1 gene product-related proteins V Defense mechanisms ; IPR004345 [TB2/DP1/HVA22-related protein] -- -- Q8BN21 Serine/threonine-protein kinase VRK2 Vrk2 168.2 162.3 193.2 171.4 160.6 173.8 1.0353894820087 0.593605628635885 0.0501735677861125 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) vaccinia related kinase 2.7.11.1 -- Casein kinase (serine/threonine/tyrosine protein kinase) T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q9CXJ1 Probable glutamate--tRNA ligase, mitochondrial Ears2 132.3 133.9 174.7 143.7 157.3 144.8 0.989008524001795 0.915992054778207 -0.0159451396440047 Nonsignificant None 2 Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation (GO:0043039) glutamyl-tRNA synthetase 6.1.1.17 ko00860 Porphyrin and chlorophyll metabolism ko00970 Aminoacyl-tRNA biosynthesis ko01100 Metabolic pathways Glutamyl-tRNA synthetase (mitochondrial) J Translation, ribosomal structure and biogenesis ; IPR020058 [Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain] -- -- B0LAC7 Myosin light polypeptide 6 alkali smooth muscle and non-muscle protein (Fragment) Myl6 446.9 494.1 495.4 563 561 569.6 0.848134152102031 0.00607169018200578 -0.237635616342931 Nonsignificant None -- -- myosin light chain 6 -- ko04270 Vascular smooth muscle contraction ko04530 Tight junction ko04921 Oxytocin signaling pathway Myosin essential light chain, EF-Hand protein superfamily Z Cytoskeleton ; -- -- -- A0A0U1RPM3 PRA1 family protein Rabac1 846.4 766.3 912.5 982.4 958.1 925 0.881242366079218 0.0669668218532455 -0.18238924004018 Nonsignificant None -- -- PRA1 family protein 1 -- -- Prenylated rab acceptor 1 U Intracellular trafficking, secretion, and vesicular transport ; IPR004895 [Prenylated rab acceptor PRA1] -- -- Q99K07 Enpp3 protein (Fragment) Enpp3 230.8 219.9 250.9 322 337.1 330.2 0.709188314970181 0.000679775328234258 -0.495759329199904 Nonsignificant None 4 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:catalytic activity (GO:0003824),Molecular Function:hydrolase activity (GO:0016787),Molecular Function:metal ion binding (GO:0046872) -- -- ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko00500 Starch and sucrose metabolism ko00740 Riboflavin metabolism ko00760 Nicotinate and nicotinamide metabolism ko00770 Pantothenate and CoA biosynthesis ko01100 Metabolic pathways Type I phosphodiesterase/nucleotide pyrophosphatase R General function prediction only ; IPR001604 [DNA/RNA non-specific endonuclease] ; IPR002591[Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase] -- -- Q3TXB1 Complement C1q subcomponent subunit A C1qa 265.6 307.7 308.8 299.8 308.9 290.2 0.981310490599622 0.731406301107918 -0.0272184116790195 Nonsignificant None -- -- complement C1q subcomponent subunit A -- ko04610 Complement and coagulation cascades ko05020 Prion diseases ko05133 Pertussis ko05142 Chagas disease (American trypanosomiasis) ko05150 Staphylococcus aureus infection ko05322 Systemic lupus erythematosus -- -- -- IPR001073 [C1q domain] ; IPR008160[Collagen triple helix repeat] -- -- Q5U3K5 Rab-like protein 6 Rabl6 166.5 154.9 197.8 171.8 168.7 167.5 1.02204724409449 0.798679405223513 0.0314618863396102 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) -- -- -- GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR013684 [Mitochondrial Rho-like] -- -- A0A3B2WB97 SH3 domain-binding glutamic acid-rich protein Sh3bgr 621.3 886.9 1150.9 1061.8 1041.8 850.3 0.900199735942314 0.58805365420013 -0.151682953352934 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR006993 [SH3-binding, glutamic acid-rich protein] -- -- Q9EST4 Proteasome assembly chaperone 2 Psmg2 404.3 388.9 356.6 357.8 363.6 354.4 1.06878601970627 0.159832541643402 0.0959730418239726 Nonsignificant None -- -- proteasome assembly chaperone 2 -- -- Uncharacterized conserved protein S Function unknown ; IPR019151 [Proteasome assembly chaperone 2] -- -- Q9JKN1 Zinc transporter 7 Slc30a7 937.3 890.5 1021.3 998.3 1056.7 968.3 0.942380842126153 0.277514600985959 -0.0856178842955272 Nonsignificant None 4 Biological Process:cation transport (GO:0006812),Molecular Function:cation transmembrane transporter activity (GO:0008324),Cellular Component:integral component of membrane (GO:0016021),Biological Process:transmembrane transport (GO:0055085) solute carrier family 30 (zinc transporter), member 5/7 -- -- Putative Zn2+ transporter MSC2 (cation diffusion facilitator superfamily) P Inorganic ion transport and metabolism ; IPR002524 [Cation efflux protein] -- -- Q9EP82 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 Wdr4 142.4 149.4 116.8 126 127.3 129.5 1.06739811912226 0.477288415018346 0.0940983742472017 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) tRNA (guanine-N(7)-)-methyltransferase subunit TRM82 -- -- WD repeat protein WDR4 S Function unknown ; IPR001680 [WD40 repeat] -- -- Q3U8B9 Uncharacterized protein (Fragment) Rpl7l1 472.5 449.9 424.2 400.9 414.6 396.5 1.11105610561056 0.0401293495936851 0.151931671130578 Nonsignificant None -- -- -- -- -- 60S ribosomal protein L7 J Translation, ribosomal structure and biogenesis ; IPR012988 [Ribosomal protein L30, N-terminal] ; IPR016082[Ribosomal protein L30, ferredoxin-like fold domain] -- -- Q923B1 Lariat debranching enzyme Dbr1 273.1 271.7 238.2 261.9 261.8 273.3 0.982434127979925 0.71780806529841 -0.0255674166994312 Nonsignificant None 2 Biological Process:mRNA processing (GO:0006397),Molecular Function:hydrolase activity (GO:0016787) lariat debranching enzyme 3.1.-.- -- RNA lariat debranching enzyme A RNA processing and modification ; IPR004843 [Calcineurin-like phosphoesterase domain, ApaH type] ; IPR007708[Lariat debranching enzyme, C-terminal] -- -- Q80TR8 DDB1- and CUL4-associated factor 1 Dcaf1 467.5 489.9 536 495.2 487.6 533.7 0.984767556874382 0.770838609843209 -0.0221448618093413 Nonsignificant None -- -- HIV-1 Vpr-binding protein -- -- HIV-1 Vpr-binding protein D Cell cycle control, cell division, chromosome partitioning ; -- -- -- Q3U661 TOX high mobility group box family member 4 Tox4 234.9 229.4 251.4 268.3 261.1 250.4 0.917799435752757 0.0639474583517319 -0.1237491750809 Nonsignificant None -- -- -- -- -- HMG box-containing protein R General function prediction only ; IPR009071 [High mobility group box domain] -- HMG A0A3Q4L2Q3 Poly(A) RNA polymerase, mitochondrial (Fragment) Mtpap 81.2 74.6 77.8 79.4 82.8 81.6 0.958162428219852 0.188935929798673 -0.0616578517401949 Nonsignificant None -- -- poly(A) RNA polymerase, mitochondrial 2.7.7.19 -- S-M checkpoint control protein CID1 and related nucleotidyltransferases D Cell cycle control, cell division, chromosome partitioning ; IPR002058 [PAP/25A-associated] -- -- Q3UQH1 Uncharacterized protein Gpr107 515.3 421.3 373.7 372.7 382.9 425.1 1.10976539341069 0.387458555030133 0.150254720236099 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) -- -- -- G protein-coupled seven transmembrane receptor T Signal transduction mechanisms ; IPR009637 [Lung seven transmembrane receptor-like] -- -- O35954 Membrane-associated phosphatidylinositol transfer protein 1 Pitpnm1 133.8 146.4 92 186.4 206.6 148.6 0.687223042836041 0.0753490688010319 -0.541149683515845 Nonsignificant None 3 Cellular Component:intracellular (GO:0005622),Biological Process:transport (GO:0006810),Molecular Function:metal ion binding (GO:0046872) -- -- -- Phosphatidylinositol transfer protein IT Lipid transport and metabolism ; Signal transduction mechanisms ; IPR001666 [Phosphatidylinositol transfer protein] ; IPR004177[DDHD domain] -- -- O35551 Rab GTPase-binding effector protein 1 Rabep1 161.2 147.9 174.5 163.4 169.8 193.1 0.918867566026981 0.295933585731827 -0.12207115024365 Nonsignificant None 2 Molecular Function:GTPase activator activity (GO:0005096),Molecular Function:growth factor activity (GO:0008083) Rab GTPase-binding effector protein 1 -- ko04144 Endocytosis Rab5 GTPase effector Rabaptin-5 U Intracellular trafficking, secretion, and vesicular transport ; IPR015390 [Rabaptin, GTPase-Rab5 binding domain] ; IPR018514[Rabaptin coiled-coil domain] -- -- Q9DC29 ATP-binding cassette sub-family B member 6 Abcb6 43.5 38 29.9 38.1 32.6 40.4 1.002700270027 0.983617940422371 0.00389041595093974 Nonsignificant None 5 Molecular Function:ATP binding (GO:0005524),Biological Process:transport (GO:0006810),Cellular Component:integral component of membrane (GO:0016021),Molecular Function:ATPase activity (GO:0016887),Biological Process:transmembrane transport (GO:0055085) ATP-binding cassette, subfamily B (MDR/TAP), member 6 -- ko02010 ABC transporters Heavy metal exporter HMT1, ABC superfamily P Inorganic ion transport and metabolism ; IPR003439 [ABC transporter-like] ; IPR011527[ABC transporter type 1, transmembrane domain] ; IPR032410[Mitochondrial ABC-transporter, N-terminal five TM domain] -- -- J3QNU1 Arginyl-tRNA--protein transferase 1 Ate1 485.6 486.5 477 470.3 463.3 457.9 1.04139417894359 0.0149922671691559 0.0585162476649867 Nonsignificant None 2 Molecular Function:arginyltransferase activity (GO:0004057),Biological Process:protein arginylation (GO:0016598) arginyl-tRNA---protein transferase 2.3.2.8 -- Arginyl-tRNA-protein transferase O Posttranslational modification, protein turnover, chaperones ; IPR007471 [Arginine-tRNA-protein transferase, N-terminal] ; IPR007472[Arginine-tRNA-protein transferase, C-terminal] -- -- Q99JT9 Acireductone dioxygenase Adi1 539 542 611.6 534.5 584.8 587.3 0.991796554552912 0.881155240763433 -0.0118838813710884 Nonsignificant None 2 Molecular Function:acireductone dioxygenase [iron(II)-requiring] activity (GO:0010309),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00270 Cysteine and methionine metabolism ko01100 Metabolic pathways Uncharacterized conserved protein, contains double-stranded beta-helix domain S Function unknown ; IPR004313 [Acireductone dioxygenase ARD family] -- -- D3Z4D7 Microfibrillar-associated protein 5 Mfap5 492.4 741.7 631.9 929.9 917.4 818.1 0.700082539206123 0.029468802002325 -0.514403070139159 Nonsignificant None 1 Cellular Component:microfibril (GO:0001527) -- -- -- -- -- -- IPR008673 [Microfibril-associated glycoprotein] -- -- A1L332 Phospholipid-transporting ATPase Atp8a1 320.2 320.1 326.4 338.3 353.1 329 0.947373578988632 0.0707982737809751 -0.0779946572868172 Nonsignificant None 2 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:metal ion binding (GO:0046872) phospholipid-transporting ATPase 3.6.3.1 -- P-type ATPase R General function prediction only ; IPR008250 [P-type ATPase, A domain] ; IPR032630[P-type ATPase, C-terminal] ; IPR032631[P-type ATPase, N-terminal] -- -- Q8BK77 Uncharacterized protein (Fragment) Tor1aip2 102.9 119.6 111.8 134.5 140.2 120.3 0.846329113924051 0.0569623659713693 -0.240709298334424 Nonsignificant None -- -- IFRG15 protein -- -- -- -- -- -- -- -- Q8CE96 tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 Trmt6 788.1 792.3 725.1 671.6 698.7 667 1.13164482403181 0.020050950323511 0.178421227594114 Nonsignificant None 2 Biological Process:tRNA methylation (GO:0030488),Cellular Component:tRNA (m1A) methyltransferase complex (GO:0031515) tRNA (adenine-N(1)-)-methyltransferase non-catalytic subunit -- -- tRNA(1-methyladenosine) methyltransferase, subunit GCD10 J Translation, ribosomal structure and biogenesis ; IPR017423 [tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6] -- -- Q8R550 SH3 domain-containing kinase-binding protein 1 Sh3kbp1 259.6 272 301.7 246.3 239 254.5 1.12638550959719 0.0786105833935998 0.171700679635838 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) SH3 domain-containing kinase-binding protein 1 -- ko04144 Endocytosis Adaptor protein CMS/SETA T Signal transduction mechanisms ; IPR001452 [SH3 domain] -- -- A0A140LIF0 5-demethoxyubiquinone hydroxylase, mitochondrial Coq7 206.2 177.9 214.3 239.5 237.2 251.6 0.821639434299053 0.0220121646970485 -0.283422669922571 Nonsignificant None 2 Biological Process:ubiquinone biosynthetic process (GO:0006744),Biological Process:oxidation-reduction process (GO:0055114) ubiquinone biosynthesis monooxygenase Coq7 1.14.13.- ko00130 Ubiquinone and other terpenoid-quinone biosynthesis ko01100 Metabolic pathways DMQ mono-oxygenase/Ubiquinone biosynthesis protein COQ7/CLK-1/CAT5 R General function prediction only ; IPR011566 [Ubiquinone biosynthesis protein Coq7] -- -- Q3THZ3 Uncharacterized protein Atp6ap1 133.8 125.1 130 115.8 127 138.2 1.02073490813648 0.723618564755381 0.029608237053524 Nonsignificant None 1 Biological Process:ATP hydrolysis coupled proton transport (GO:0015991) V-type H+-transporting ATPase S1 subunit -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04142 Lysosome ko04145 Phagosome ko05152 Tuberculosis ko05161 Hepatitis B ko05323 Rheumatoid arthritis Vacuolar H+-ATPase V0 sector, accessory subunit S1 (Ac45) C Energy production and conversion ; IPR008388 [ATPase, V1 complex, subunit S1] -- -- A0A0R4J023 Methylglutaconyl-CoA hydratase, mitochondrial Auh 687.1 703.9 821.2 844.4 794.7 906.4 0.869063052445492 0.104712911670444 -0.202467243336208 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) methylglutaconyl-CoA hydratase 4.2.1.18 ko00280 Valine, leucine and isoleucine degradation ko01100 Metabolic pathways Enoyl-CoA hydratase I Lipid transport and metabolism ; IPR001753 [Crotonase superfamily] -- -- Q80SY5 Pre-mRNA-splicing factor 38B Prpf38b 239 257.3 298.1 302 315.2 298.1 0.867912159947558 0.091413886602279 -0.204379057771439 Nonsignificant None -- -- pre-mRNA-splicing factor 38B -- ko03040 Spliceosome Putative RNA binding protein R General function prediction only ; IPR005037 [Pre-mRNA-splicing factor 38] -- -- Q91XB0 Three-prime repair exonuclease 1 Trex1 544.8 608.5 669.3 530.4 515.8 517.6 1.16549430873513 0.136273462694171 0.220941959610796 Nonsignificant None -- -- three prime repair exonuclease 1 3.1.11.2 ko04623 Cytosolic DNA-sensing pathway Three prime repair exonuclease L Replication, recombination and repair ; -- -- -- Q9D4G5 Processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae) Pop1 201.7 209.5 194.5 199.5 183.1 203.6 1.03326509723644 0.441422561767342 0.0472104433630881 Nonsignificant None 3 Biological Process:tRNA 5'-leader removal (GO:0001682),Molecular Function:ribonuclease P activity (GO:0004526),Biological Process:RNA processing (GO:0006396) ribonuclease P/MRP protein subunit POP1 3.1.26.5 ko03008 Ribosome biogenesis in eukaryotes ko03013 RNA transport Ribonucleases P/MRP protein subunit A RNA processing and modification ; IPR009723 [Ribonuclease P/MRP, subunit POP1] ; IPR012590[POPLD] -- -- O88351 Inhibitor of nuclear factor kappa-B kinase subunit beta Ikbkb 248.5 256.6 279.7 245.2 238.5 247.6 1.07315739094763 0.140942521674022 0.101861679531339 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468),Molecular Function:IkappaB kinase activity (GO:0008384) inhibitor of nuclear factor kappa-B kinase subunit beta 2.7.11.10 ko01523 Antifolate resistance ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04062 Chemokine signaling pathway ko04064 NF-kappa B signaling pathway ko04068 FoxO signaling pathway ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04210 Apoptosis ko04380 Osteoclast differentiation ko04620 Toll-like receptor signaling pathway ko04621 NOD-like receptor signaling pathway ko04622 RIG-I-like receptor signaling pathway ko04623 Cytosolic DNA-sensing pathway ko04657 IL-17 signaling pathway ko04658 Th1 and Th2 cell differentiation ko04659 Th17 cell differentiation ko04660 T cell receptor signaling pathway ko04662 B cell receptor signaling pathway ko04668 TNF signaling pathway ko04722 Neurotrophin signaling pathway ko04910 Insulin signaling pathway ko04920 Adipocytokine signaling pathway ko04930 Type II diabetes mellitus ko04931 Insulin resistance ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05142 Chagas disease (American trypanosomiasis) ko05145 Toxoplasmosis ko05160 Hepatitis C ko05161 Hepatitis B ko05164 Influenza A ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05206 MicroRNAs in cancer ko05212 Pancreatic cancer ko05215 Prostate cancer ko05220 Chronic myeloid leukemia ko05221 Acute myeloid leukemia ko05222 Small cell lung cancer ko05418 Fluid shear stress and atherosclerosis TANK binding protein kinase TBK1 T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR022007[I-kappa-kinase-beta NEMO binding domain] -- -- F8VPV0 Pericentrin Pcnt 162.8 189.8 167.3 208 211.8 178.5 0.868962059167642 0.123645177172847 -0.20263490777363 Nonsignificant None -- -- pericentrin -- -- -- -- -- IPR019528 [Pericentrin/AKAP-450 centrosomal targeting domain] -- -- Q8R593 Ring finger and CHY zinc finger domain containing 1 Rchy1 208.4 214.8 328.6 277.2 313.7 293.9 0.849683544303798 0.334569756512036 -0.23500247019169 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:zinc ion binding (GO:0008270) RING finger and CHY zinc finger domain-containing protein 1 2.3.2.27 ko04115 p53 signaling pathway ko04120 Ubiquitin mediated proteolysis ko05162 Measles Zn-finger protein R General function prediction only ; IPR001841 [Zinc finger, RING-type] ; IPR008913[Zinc finger, CHY-type] -- -- Q6WIZ9 RBR-type E3 ubiquitin transferase Rnf31 125.3 139.2 183.3 152.2 173.3 185.5 0.876320939334638 0.351757153242294 -0.190468762972386 Nonsignificant None -- -- E3 ubiquitin-protein ligase RNF31 2.3.2.27 ko04217 Necroptosis ko04621 NOD-like receptor signaling pathway Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR002867 [IBR domain] ; IPR018997[PUB domain] ; IPR032065[E3 ubiquitin-protein ligase RNF31, UB-associated-like domain] -- -- Q9D869 Calcineurin B homologous protein 2 Chp2 136.6 123.9 122.8 136.4 121.6 139.5 0.964276729559748 0.54032645996527 -0.0524808622585622 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) calcineurin B homologous protein 2 -- -- Ca2+/calmodulin-dependent protein phosphatase (calcineurin subunit B), EF-Hand superfamily protein T Signal transduction mechanisms ; IPR002048 [EF-hand domain] -- -- Q9EP72 ER membrane protein complex subunit 7 Emc7 785.6 785.7 775.9 655.8 677.3 686.9 1.1619801980198 0.000363852245063361 0.216585483146871 Nonsignificant None -- -- -- -- -- Predicted membrane protein S Function unknown ; IPR019008 [Domain of unknown function DUF2012] -- -- Q9CWD1 Uncharacterized protein Tmem33 450.2 404.1 383.6 346.2 344.6 320.5 1.22406803124691 0.0241534099159004 0.291683742356584 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) transmembrane protein 33 -- -- Uncharacterized integral membrane protein S Function unknown ; IPR005344 [Per33/Pom33 family] -- -- Q3TVY3 Uncharacterized protein 433.5 405.9 460.8 464.2 469.4 458.8 0.933783395575984 0.129632790222567 -0.0988401599088529 Nonsignificant None -- -- -- -- -- -- -- -- IPR028260 [FAM177 family] -- -- Q5H8C4 Intermembrane lipid transfer protein VPS13A Vps13a 106.9 95.5 90.1 102 102.5 113.6 0.919522162841874 0.242842324194369 -0.121043747181384 Nonsignificant None -- -- vacuolar protein sorting-associated protein 13A/C -- -- Vacuolar protein sorting-associated protein U Intracellular trafficking, secretion, and vesicular transport ; IPR009543 [Vacuolar protein sorting-associated protein 13, SHR-binding domain] ; IPR015412[Autophagy-related, C-terminal] ; IPR026854[Vacuolar protein sorting-associated protein 13, N-terminal domain] ; IPR031642[VPS13, repeated coiled region] ; IPR031645[Vacuolar protein sorting-associated protein 13, C-terminal] ; IPR031646[Vacuolar protein sorting-associated protein 13, second N-terminal domain] -- -- F6WBP9 Stromal interaction molecule 2 (Fragment) Stim2 98.3 106.2 91.5 118.3 126 108.3 0.839478162223483 0.0471174716989389 -0.25243529880387 Nonsignificant None -- -- stromal interaction molecule 2 -- ko04020 Calcium signaling pathway Cell surface glycoprotein STIM, contains SAM domain R General function prediction only ; IPR032393 [Stromal interaction molecule, Orai1-activating region] -- -- Q8R2U0 Nucleoporin SEH1 Seh1l 375.5 415.2 399.8 399.3 413.6 411.2 0.972551262151785 0.416550360269157 -0.0401537998496445 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) nucleoporin SEH1 -- ko03013 RNA transport ko04150 mTOR signaling pathway Nuclear pore complex component (sc Seh1) YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; IPR001680 [WD40 repeat] -- -- Q60767 Lymphocyte antigen 75 Ly75 335.1 337.5 383.6 423.3 482.6 466.3 0.769712869844046 0.0113027191969546 -0.37760772506139 Nonsignificant None -- -- lymphocyte antigen 75 -- -- C-type lectin TV Signal transduction mechanisms ; Defense mechanisms ; IPR000562 [Fibronectin, type II, collagen-binding] ; IPR001304[C-type lectin-like] -- -- Q9D8Q8 BPTI/Kunitz inhibitor domain-containing protein Spint2 584.6 480 498.7 439.2 497.9 492.7 1.09336970205623 0.298462224658406 0.128781303241278 Nonsignificant None 1 Molecular Function:serine-type endopeptidase inhibitor activity (GO:0004867) -- -- -- Serine proteinase inhibitor (KU family) O Posttranslational modification, protein turnover, chaperones ; IPR002223 [Pancreatic trypsin inhibitor Kunitz domain] -- -- Q3UN22 Uncharacterized protein 143.8 124.1 123.9 218.8 262.9 255.1 0.531758957654723 0.001598046963032 -0.911155663823749 Significant down 4 Molecular Function:galactosylceramide sulfotransferase activity (GO:0001733),Cellular Component:Golgi apparatus (GO:0005794),Biological Process:glycolipid biosynthetic process (GO:0009247),Cellular Component:integral component of membrane (GO:0016021) galactose-3-O-sulfotransferase 2 2.8.2.- -- -- -- -- IPR009729 [Galactose-3-O-sulfotransferase] -- -- Q8BHT6 Beta-1,3-glucosyltransferase B3glct 400.5 374.7 367.6 393.8 387.9 411.4 0.957840918615372 0.242496233206689 -0.0621420265899955 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) UDP-glucose:O-linked fucose beta-1,3-glucosyltransferase 2.4.1.- ko00514 Other types of O-glycan biosynthesis -- -- -- IPR003378 [Fringe-like] -- -- Q8QZZ7 EKC/KEOPS complex subunit Tprkb Tprkb 60.8 60 55 73.3 70.3 64.9 0.843165467625899 0.0234205052864734 -0.246112313188622 Nonsignificant None -- -- EKC/KEOPS complex subunit CGI121/TPRKB -- -- Cell growth regulatory protein CGR11 S Function unknown ; IPR013926 [CGI121/TPRKB] -- -- Q7TT18 Activating transcription factor 7-interacting protein 1 Atf7ip 132.2 124.2 125.3 107.9 115.7 116.5 1.12231696559835 0.0202292639522704 0.166480180507716 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR003961 [Fibronectin type III] ; IPR031870[ATF7-interacting protein , protein binding domain] -- -- Q5XPI3 E3 ubiquitin-protein ligase RNF123 Rnf123 305.6 338.8 388.5 273.7 278.4 271.8 1.25367156208278 0.100690754475282 0.326159439195024 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) Kip1 ubiquitination-promoting complex protein 1 2.3.2.27 -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR003877 [SPRY domain] -- -- E9QM73 Non-specific serine/threonine protein kinase Wnk2 14 11.1 16.5 15.5 14.9 17.7 0.864864864864865 0.289793580648003 -0.20945336562895 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) WNK lysine deficient protein kinase 2.7.11.1 -- -- -- -- IPR000719 [Protein kinase domain] ; IPR024678[Serine/threonine-protein kinase OSR1/WNK, CCT domain] -- -- Q3TQJ2 UDP-glucose--hexose-1-phosphate uridylyltransferase Galt 481.9 484.8 503.6 528.2 520.9 549.5 0.919742274490179 0.0174505990126926 -0.120698441766325 Nonsignificant None 2 Biological Process:galactose metabolic process (GO:0006012),Molecular Function:UDP-glucose:hexose-1-phosphate uridylyltransferase activity (GO:0008108) UDPglucose--hexose-1-phosphate uridylyltransferase 2.7.7.12 ko00052 Galactose metabolism ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways ko04917 Prolactin signaling pathway Galactose-1-phosphate uridylyltransferase C Energy production and conversion ; IPR005849 [Galactose-1-phosphate uridyl transferase, N-terminal] ; IPR005850[Galactose-1-phosphate uridyl transferase, C-terminal] -- -- Q8BKJ9 NAD-dependent protein deacetylase sirtuin-7 Sirt7 124.3 108.5 104.4 112.5 98.4 119.2 1.02150863374735 0.797351546148719 0.0307013977195464 Nonsignificant None 1 Molecular Function:NAD+ binding (GO:0070403) NAD-dependent deacetylase sirtuin 7 3.5.1.- -- Class IV sirtuins (SIR2 family) BK Chromatin structure and dynamics ; Transcription ; IPR003000 [Sirtuin family] -- -- Q9ET22 Dipeptidyl peptidase 2 Dpp7 473.8 437.1 514.6 585.3 608.7 610.9 0.789794448445897 0.0060624516821665 -0.340450867919339 Nonsignificant None 2 Biological Process:proteolysis (GO:0006508),Molecular Function:serine-type peptidase activity (GO:0008236) dipeptidyl-peptidase II 3.4.14.2 -- Prolylcarboxypeptidase (angiotensinase C) OR Posttranslational modification, protein turnover, chaperones ; General function prediction only ; IPR008758 [Peptidase S28] -- -- E9Q9E4 Cyclin-dependent kinase 4 (Fragment) Cdk4 853.4 882.4 913.6 684.1 700.1 577.5 1.350563286945 0.00558276634192062 0.433561245639131 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) cyclin-dependent kinase 4 2.7.11.22 ko01522 Endocrine resistance ko04110 Cell cycle ko04115 p53 signaling pathway ko04151 PI3K-Akt signaling pathway ko04218 Cellular senescence ko04530 Tight junction ko04660 T cell receptor signaling pathway ko04933 AGE-RAGE signaling pathway in diabetic complications ko05161 Hepatitis B ko05162 Measles ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05212 Pancreatic cancer ko05214 Glioma ko05218 Melanoma ko05219 Bladder cancer ko05220 Chronic myeloid leukemia ko05222 Small cell lung cancer ko05223 Non-small cell lung cancer ko05224 Breast cancer ko05225 Hepatocellular carcinoma Protein kinase PCTAIRE and related kinases R General function prediction only ; IPR000719 [Protein kinase domain] -- -- Q0VGZ0 Gtf2a1 protein Gtf2a1 144 137.9 139 125 141.1 117.6 1.09695074276779 0.159530769156365 0.133498744738262 Nonsignificant None 2 Cellular Component:transcription factor TFIIA complex (GO:0005672),Biological Process:transcription initiation from RNA polymerase II promoter (GO:0006367) transcription initiation factor TFIIA large subunit -- ko03022 Basal transcription factors ko05203 Viral carcinogenesis RNA polymerase II transcription initiation factor TFIIA, large chain K Transcription ; IPR004855 [Transcription factor IIA, alpha/beta subunit] -- -- A0A0A0MQM2 Phosphoinositide phospholipase C Plch1 1358.1 1326.8 1483.1 1162.8 1270.2 1177.7 1.15434680255906 0.0334697647841622 0.207076720661914 Nonsignificant None 5 Molecular Function:phosphatidylinositol phospholipase C activity (GO:0004435),Molecular Function:protein binding (GO:0005515),Biological Process:lipid metabolic process (GO:0006629),Biological Process:signal transduction (GO:0007165),Biological Process:intracellular signal transduction (GO:0035556) phosphatidylinositol phospholipase C, eta 3.1.4.11 ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways Phosphoinositide-specific phospholipase C T Signal transduction mechanisms ; IPR000008 [C2 domain] ; IPR000909[Phosphatidylinositol-specific phospholipase C, X domain] ; IPR001711[Phospholipase C, phosphatidylinositol-specific, Y domain] ; IPR015359[Phosphoinositide-specific phospholipase C, EF-hand-like domain] -- -- Q8QZY6 Tetraspanin-14 Tspan14 269.9 258.2 258.8 325 297.9 319.8 0.834730030762703 0.00472334676487543 -0.260618419763657 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) tetraspanin-14 -- -- Tetraspanin family integral membrane protein R General function prediction only ; IPR018499 [Tetraspanin/Peripherin] -- -- A0A0A0MQ68 Glutaryl-CoA dehydrogenase, mitochondrial Gcdh 36.2 27.7 33 30.5 36.1 46.6 0.856007067137809 0.365674763611867 -0.224305387416801 Nonsignificant None 4 Molecular Function:acyl-CoA dehydrogenase activity (GO:0003995),Biological Process:metabolic process (GO:0008152),Molecular Function:flavin adenine dinucleotide binding (GO:0050660),Biological Process:oxidation-reduction process (GO:0055114) glutaryl-CoA dehydrogenase 1.3.8.6 ko00071 Fatty acid degradation ko00310 Lysine degradation ko00380 Tryptophan metabolism ko01100 Metabolic pathways Glutaryl-CoA dehydrogenase E Amino acid transport and metabolism ; IPR006091 [Acyl-CoA oxidase/dehydrogenase, central domain] ; IPR009075[Acyl-CoA dehydrogenase/oxidase C-terminal] ; IPR013786[Acyl-CoA dehydrogenase/oxidase, N-terminal] -- -- Q3TI30 Uncharacterized protein Wdr75 292.8 282.3 311.6 275.4 319.8 267.1 1.02829641656036 0.682411728250598 0.0402561955242195 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) NET1-associated nuclear protein 1 (U3 small nucleolar RNA-associated protein 17) -- ko03008 Ribosome biogenesis in eukaryotes WD40 repeat protein R General function prediction only ; IPR001680 [WD40 repeat] -- -- P59016 Vacuolar protein sorting-associated protein 33B Vps33b 389.9 381 420.9 490.9 528.8 510.1 0.779056085762845 0.00230248007566378 -0.360200900439636 Nonsignificant None 2 Biological Process:vesicle docking involved in exocytosis (GO:0006904),Biological Process:vesicle-mediated transport (GO:0016192) -- -- -- Vacuolar sorting protein VPS33/slp1 (Sec1 family) U Intracellular trafficking, secretion, and vesicular transport ; IPR001619 [Sec1-like protein] -- -- Q61526 Receptor tyrosine-protein kinase erbB-3 Erbb3 449.2 384.8 396.7 397.9 419 393 1.01719150343004 0.761447395124654 0.0245913164028008 Nonsignificant None 6 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:transmembrane receptor protein tyrosine kinase activity (GO:0004714),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468),Biological Process:transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169),Cellular Component:membrane (GO:0016020) receptor tyrosine-protein kinase erbB-3 2.7.10.1 ko01521 EGFR tyrosine kinase inhibitor resistance ko04012 ErbB signaling pathway ko04020 Calcium signaling pathway ko05205 Proteoglycans in cancer ko05206 MicroRNAs in cancer Epidermal growth factor receptor EGFR and related tyrosine kinases T Signal transduction mechanisms ; IPR000494 [Receptor L-domain] ; IPR001245[Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR006211[Furin-like cysteine-rich domain] ; IPR032778[Growth factor receptor domain 4] -- -- Q9JJF3 Ribosomal oxygenase 1 Riox1 466 585.6 686.6 609.6 621.4 597.9 0.950407348679534 0.682785985749429 -0.0733821035902943 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR003347 [JmjC domain] -- -- Q5YD48 APOBEC1 complementation factor A1cf 311.5 279.8 306.6 317.1 315.4 323 0.939717425431711 0.130588565903881 -0.0897010936455617 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- Heterogeneous nuclear ribonucleoprotein R (RRM superfamily) A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- Q9CQL4 39S ribosomal protein L20, mitochondrial Mrpl20 424.7 395.9 399.8 385.7 373.7 395.9 1.05634900025967 0.121502786152432 0.0790865560605147 Nonsignificant None 5 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412),Molecular Function:rRNA binding (GO:0019843) large subunit ribosomal protein L20 -- ko03010 Ribosome Mitochondrial/chloroplast ribosomal protein L20 J Translation, ribosomal structure and biogenesis ; IPR005813 [Ribosomal protein L20] -- -- Q9D8N2 DENN domain-containing protein 10 Dennd10 100.8 134.9 115.7 124.2 121.6 141.9 0.90637090533918 0.361343244036622 -0.141826543742804 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- P59481 VIP36-like protein Lman2l 333.8 319.5 337.1 358.6 322.7 320.2 0.988916625062406 0.798024182492998 -0.0160792014858054 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) lectin, mannose-binding 2-like -- -- Lectin VIP36, involved in the transport of glycoproteins carrying high mannose-type glycans U Intracellular trafficking, secretion, and vesicular transport ; IPR005052 [Legume-like lectin] -- -- Q91W87 Cytochrome P450 Cyp2d22 62.2 64.2 91.2 126.8 138.2 132.2 0.547834843907351 0.00379209362358798 -0.868187066278034 Significant down 3 Molecular Function:iron ion binding (GO:0005506),Molecular Function:heme binding (GO:0020037),Biological Process:oxidation-reduction process (GO:0055114) cytochrome P450 family 2 subfamily D 1.14.14.1 ko00140 Steroid hormone biosynthesis ko04726 Serotonergic synapse Cytochrome P450 CYP2 subfamily Q Secondary metabolites biosynthesis, transport and catabolism ; IPR001128 [Cytochrome P450] -- -- Q99J09 Methylosome protein 50 Wdr77 419.2 426.7 438.5 434.3 443.3 437.5 0.976655767622234 0.174407121059274 -0.0340779358194584 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) methylosome protein 50 -- -- Polyadenylation factor I complex, subunit PFS2 A RNA processing and modification ; IPR001680 [WD40 repeat] -- -- Q8VDS4 Regulation of nuclear pre-mRNA domain-containing protein 1A Rprd1a 75.3 91.7 99.5 105 109.7 109.5 0.822023442319556 0.0577838455920863 -0.282748557871003 Nonsignificant None -- -- -- -- -- Regulator of nuclear mRNA A RNA processing and modification ; IPR006903 [RNA polymerase II-binding domain] ; IPR032337[Cell-cycle alteration and expression-elevated protein in tumour] -- -- A0A0A6YW53 Mitogen-activated protein kinase kinase kinase kinase 4 Map4k4 208.5 225.6 248.1 254.8 260.7 236 0.907784431137725 0.166400156898933 -0.139578349190323 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) mitogen-activated protein kinase kinase kinase kinase 4 2.7.11.1 ko04010 MAPK signaling pathway Traf2- and Nck-interacting kinase and related germinal center kinase (GCK) family protein kinases T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR001180[Citron homology (CNH) domain] -- -- Q99MJ9 ATP-dependent RNA helicase DDX50 Ddx50 216.6 190.9 196.4 185.4 207.4 180.1 1.05411066503753 0.417503669278031 0.0760263352102982 Nonsignificant None 5 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:RNA binding (GO:0003723),Molecular Function:helicase activity (GO:0004386),Molecular Function:ATP binding (GO:0005524),Cellular Component:nucleus (GO:0005634) ATP-dependent RNA helicase DDX50 3.6.4.13 -- ATP-dependent RNA helicase A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR011545[DEAD/DEAH box helicase domain] ; IPR012562[GUCT] -- -- Q8BT06 Tetraspanin Cd63 805.2 776.7 1091.9 1095.2 1099.6 1011.2 0.833998752339364 0.165387839928967 -0.261882869485 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) CD63 antigen -- ko04142 Lysosome ko05205 Proteoglycans in cancer Tetraspanin family integral membrane protein R General function prediction only ; IPR018499 [Tetraspanin/Peripherin] -- -- Q8BM96 Adhesion G-protein coupled receptor G7 Adgrg7 331.9 321 403.9 393.4 404.8 366.5 0.907358117970293 0.273769595188638 -0.140256025887539 Nonsignificant None 4 Molecular Function:G-protein coupled receptor activity (GO:0004930),Biological Process:G-protein coupled receptor signaling pathway (GO:0007186),Cellular Component:membrane (GO:0016020),Cellular Component:integral component of membrane (GO:0016021) G protein-coupled receptor 128 -- -- G protein-coupled receptors T Signal transduction mechanisms ; IPR000203 [GPS motif] ; IPR000832[GPCR, family 2, secretin-like] -- -- Q3TKY6 Spliceosome-associated protein CWC27 homolog Cwc27 388 346.7 305.3 287.6 318.5 312.8 1.13178800740015 0.191234744673067 0.178603755595703 Nonsignificant None 3 Biological Process:protein peptidyl-prolyl isomerization (GO:0000413),Molecular Function:peptidyl-prolyl cis-trans isomerase activity (GO:0003755),Biological Process:protein folding (GO:0006457) peptidyl-prolyl cis-trans isomerase SDCCAG10 5.2.1.8 -- Peptidyl-prolyl cis-trans isomerase O Posttranslational modification, protein turnover, chaperones ; IPR002130 [Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain] -- -- P61804 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 Dad1 186.9 184.4 186.8 188.5 205 178.4 0.975869907326456 0.613779316309065 -0.0352392591529414 Nonsignificant None 3 Molecular Function:dolichyl-diphosphooligosaccharide-protein glycotransferase activity (GO:0004579),Cellular Component:oligosaccharyltransferase complex (GO:0008250),Cellular Component:integral component of membrane (GO:0016021) oligosaccharyltransferase complex subunit epsilon -- ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways ko04141 Protein processing in endoplasmic reticulum Defender against cell death protein/oligosaccharyltransferase, epsilon subunit DO Cell cycle control, cell division, chromosome partitioning ; Posttranslational modification, protein turnover, chaperones ; IPR003038 [DAD/Ost2] -- -- H7CHP8 Euchromatic histone methyltransferase 1 Ehmt1 499.9 560.9 215.1 679 730.9 493.9 0.67018594390167 0.178869038761833 -0.577366666291874 Nonsignificant None 5 Molecular Function:protein binding (GO:0005515),Cellular Component:nucleus (GO:0005634),Molecular Function:zinc ion binding (GO:0008270),Molecular Function:histone-lysine N-methyltransferase activity (GO:0018024),Biological Process:histone lysine methylation (GO:0034968) euchromatic histone-lysine N-methyltransferase 2.1.1.43 ko00310 Lysine degradation ko04211 Longevity regulating pathway Histone H3 (Lys9) methyltransferase SUV39H1/Clr4, required for transcriptional silencing BK Chromatin structure and dynamics ; Transcription ; IPR001214 [SET domain] ; IPR007728[Pre-SET domain] ; IPR020683[Ankyrin repeat-containing domain] -- -- Q9CQS4 Mitochondrial outer membrane protein SLC25A46 Slc25a46 600.1 610.3 622.9 589 608.1 606.6 1.01641071131563 0.334734486662142 0.0234834842430963 Nonsignificant None -- -- solute carrier family 25, member 46 -- -- Mitochondrial carrier protein R General function prediction only ; IPR018108 [Mitochondrial substrate/solute carrier] -- -- Q9D710 Thioredoxin-related transmembrane protein 2 Tmx2 480.4 464.6 458.6 445.9 446.2 462.3 1.03632604843473 0.124678693483109 0.0514779745065252 Nonsignificant None 1 Biological Process:cell redox homeostasis (GO:0045454) -- -- -- Thioredoxin-like protein O Posttranslational modification, protein turnover, chaperones ; IPR013766 [Thioredoxin domain] -- -- A0A571BEK9 Squalene synthase Fdft1 82.5 70.4 69 80.6 69 83 0.953998280309544 0.58938149344719 -0.0679414292762069 Nonsignificant None 2 Biological Process:biosynthetic process (GO:0009058),Molecular Function:transferase activity (GO:0016740) farnesyl-diphosphate farnesyltransferase 2.5.1.21 ko00100 Steroid biosynthesis ko01100 Metabolic pathways Squalene synthetase I Lipid transport and metabolism ; IPR002060 [Squalene/phytoene synthase] -- -- Q3UPI3 Protein kinase domain-containing protein Cdk16 14.2 17.9 14.6 22 19.7 21.5 0.738924050632911 0.0157285055347253 -0.436502008467441 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) cyclin-dependent kinase 16 2.7.11.22 -- Protein kinase PCTAIRE and related kinases R General function prediction only ; IPR000719 [Protein kinase domain] -- -- Q3TN26 Uncharacterized protein Slc27a1 254.7 196.4 195.9 254.6 238.5 264.8 0.853674627259533 0.152634854684358 -0.228241794461719 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) solute carrier family 27 (fatty acid transporter), member 1/4 6.2.1.- ko03320 PPAR signaling pathway ko04931 Insulin resistance Very long-chain acyl-CoA synthetase/fatty acid transporter I Lipid transport and metabolism ; IPR000873 [AMP-dependent synthetase/ligase] ; IPR025110[AMP-binding enzyme C-terminal domain] -- -- Q920X9 Monocyte differentiation antigen CD14 (Fragment) CD14 300.6 372.4 353.3 283.7 312.8 298.9 1.14619164619165 0.131371448262555 0.196848286585512 Nonsignificant None -- -- monocyte differentiation antigen CD14 -- ko04010 MAPK signaling pathway ko04064 NF-kappa B signaling pathway ko04145 Phagosome ko04620 Toll-like receptor signaling pathway ko04640 Hematopoietic cell lineage ko04810 Regulation of actin cytoskeleton ko05132 Salmonella infection ko05133 Pertussis ko05134 Legionellosis ko05146 Amoebiasis ko05152 Tuberculosis ko05202 Transcriptional misregulation in cancer ko05221 Acute myeloid leukemia -- -- -- -- -- -- Q9DCC7 Isochorismatase domain-containing protein 2B Isoc2b 45.3 44.9 42.6 63.3 61.3 118.3 0.54672704816797 0.188098171108204 -0.87110734328894 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) -- -- -- Mitochondrial associated endoribonuclease MAR1 (isochorismatase superfamily) R General function prediction only ; IPR000868 [Isochorismatase-like] -- -- Q80V86 Integrator complex subunit 8 Ints8 130.6 126 126.4 130.1 117.4 122.2 1.03597511495807 0.328164315848351 0.0509893486250762 Nonsignificant None -- -- integrator complex subunit 8 -- -- -- -- -- -- -- -- Q3UKZ1 Syndecan Sdc4 157.1 164.1 167.1 203.9 190.3 181.3 0.848479582971329 0.0156870300289347 -0.237048150382129 Nonsignificant None -- -- syndecan 4 -- ko04512 ECM-receptor interaction ko04514 Cell adhesion molecules (CAMs) ko05205 Proteoglycans in cancer ko05418 Fluid shear stress and atherosclerosis -- -- -- IPR027789 [Syndecan/Neurexin domain] -- -- P58404 Striatin-4 Strn4 349.8 333 340.1 341.9 350.5 338.2 0.992528624102465 0.694678929435745 -0.010819385321749 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) striatin 1/3/4 -- Cell-cycle nuclear protein, contains WD-40 repeats D Cell cycle control, cell division, chromosome partitioning ; IPR001680 [WD40 repeat] ; IPR013258[Striatin, N-terminal] -- -- P84086 Complexin-2 Cplx2 234.5 227.1 272 264.4 313.5 303.3 0.83250113481616 0.0735960713111391 -0.264475856105829 Nonsignificant None 2 Biological Process:neurotransmitter transport (GO:0006836),Molecular Function:syntaxin binding (GO:0019905) complexin-1/2 -- ko04721 Synaptic vesicle cycle -- -- -- IPR008849 [Synaphin] -- -- Q6NSQ7 Protein LTV1 homolog Ltv1 215.6 215.5 196.4 186.2 182.2 167.5 1.17092741183057 0.0233345517434777 0.227651643014204 Nonsignificant None -- -- protein LTV1 -- -- Uncharacterized conserved protein S Function unknown ; IPR007307 [Low temperature viability protein] -- -- Q8CI75 DIS3-like exonuclease 2 Dis3l2 362.3 350.1 306.4 312 324.4 353.7 1.02898697101303 0.672276361111029 0.0412247150074959 Nonsignificant None -- -- DIS3-like exonuclease 2 3.1.13.- -- Exosomal 3'-5' exoribonuclease complex, subunit Rrp44/Dis3 J Translation, ribosomal structure and biogenesis ; IPR033771 [Rrp44-like cold shock domain] -- -- Q3UFZ4 Nucleolar protein 10 Nol10 296.2 296.3 287.4 246.3 214 242.1 1.25270501138952 0.00498257840101314 0.325046726942754 Nonsignificant None 1 Cellular Component:nucleus (GO:0005634) ribosome biogenesis protein ENP2 -- -- WD40 repeat protein R General function prediction only ; IPR012580 [NUC153] -- -- A0A1B0GSZ9 39S ribosomal protein L23, mitochondrial Mrpl23 135 113.4 182.2 156.1 174.1 154.1 0.88911831509395 0.447724092388765 -0.169552683434391 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L23 -- ko03010 Ribosome Predicted mitochondrial ribosomal protein L23 J Translation, ribosomal structure and biogenesis ; IPR013025 [Ribosomal protein L25/L23] -- -- A2AUM2 Non-specific serine/threonine protein kinase Eif2ak4 173.1 183.7 219.5 209.2 209.6 203 0.926825345770344 0.393056849849106 -0.109630596954381 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) eukaryotic translation initiation factor 2-alpha kinase 4 2.7.11.1 ko04140 Autophagy - animal ko04141 Protein processing in endoplasmic reticulum ko05160 Hepatitis C ko05162 Measles ko05164 Influenza A ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection eIF-2alpha kinase GCN2 J Translation, ribosomal structure and biogenesis ; IPR000719 [Protein kinase domain] ; IPR024435[Histidyl tRNA synthetase-related domain] -- -- M0QWC2 Microtubule-associated proteins 1A/1B light chain 3B Map1lc3b 316.4 285.6 272.6 266.2 265.5 293.7 1.05960746304822 0.362371129907851 0.083529910074173 Nonsignificant None -- -- microtubule-associated protein 1 light chain -- ko04216 Ferroptosis Microtubule-associated anchor protein involved in autophagy and membrane trafficking Z Cytoskeleton ; IPR004241 [Autophagy protein Atg8 ubiquitin-like] -- -- Q8CI71 Syndetin Vps50 221.6 198.8 210.7 204.5 219.5 213.8 0.989495139542176 0.791509575406086 -0.0152354741993357 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019514 [Protein of unknown function DUF2451, C-terminal] ; IPR019515[Vacuolar protein sorting-associated protein 54, N-terminal] -- -- Q6YJU2 GUGU alpha Fetub 597.1 600 527.8 483.4 515.8 436.9 1.2011002019358 0.0429111848979947 0.264356513079928 Nonsignificant None 1 Molecular Function:cysteine-type endopeptidase inhibitor activity (GO:0004869) -- -- -- -- -- -- IPR000010 [Cystatin domain] -- -- D3YZJ1 Sequestosome-1 Sqstm1 234.7 261.3 200.8 261.7 265.3 230.5 0.91986798679868 0.383734833696951 -0.120501264648811 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:zinc ion binding (GO:0008270) sequestosome 1 -- ko04137 Mitophagy - animal ko04217 Necroptosis ko04218 Cellular senescence ko04380 Osteoclast differentiation ko05418 Fluid shear stress and atherosclerosis Uncharacterized conserved protein, contains ZZ-type Zn-finger R General function prediction only ; IPR000270 [PB1 domain] ; IPR000433[Zinc finger, ZZ-type] -- -- Q6PCM2 Integrator complex subunit 6 Ints6 481.1 446.1 611.1 817.8 793.6 754.1 0.650306489114352 0.00673401956564033 -0.620808275036016 Significant down -- -- integrator complex subunit 6 -- -- DEAD box RNA helicase R General function prediction only ; IPR002035 [von Willebrand factor, type A] ; IPR029307[INTS6/SAGE1/DDX26B/CT45, C-terminal] -- -- Q99M07 Cytochrome c oxidase assembly factor 5 Coa5 41 49.8 54.7 60.4 73.8 65 0.730421686746988 0.0332646655554475 -0.453198494272435 Nonsignificant None -- -- cytochrome c oxidase assembly factor 5 -- -- Cytochrome c oxidase assembly protein PET191 O Posttranslational modification, protein turnover, chaperones ; IPR018793 [Cytochrome c oxidase assembly protein PET191] -- -- A6H6H4 Thymosin beta Tmsb10 2859.2 2726.1 355.3 313.4 360.1 349.3 5.80817364098553 0.181383621042742 2.53808458474621 Nonsignificant None 2 Molecular Function:actin monomer binding (GO:0003785),Biological Process:actin filament organization (GO:0007015) thymosin beta 10 -- -- Thymosin beta N Cell motility ; IPR001152 [Beta-thymosin] -- -- Q8C163 Nuclease EXOG, mitochondrial Exog 131 129.2 120.3 100.7 116.8 124.9 1.11127336448598 0.180727151013147 0.152213751989761 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:hydrolase activity (GO:0016787),Molecular Function:metal ion binding (GO:0046872) nuclease EXOG, mitochondrial -- -- Mitochondrial endonuclease F Nucleotide transport and metabolism ; IPR001604 [DNA/RNA non-specific endonuclease] -- -- A0A0R4IZY9 tRNA-dihydrouridine(47) synthase [NAD(P)(+)] Dus3l 1124.7 1109.6 1114.4 1065.9 1132.2 1067.8 1.02535288894332 0.282427983176279 0.0361205180329211 Nonsignificant None 4 Biological Process:tRNA processing (GO:0008033),Molecular Function:tRNA dihydrouridine synthase activity (GO:0017150),Molecular Function:flavin adenine dinucleotide binding (GO:0050660),Biological Process:oxidation-reduction process (GO:0055114) tRNA-dihydrouridine synthase 3 1.3.1.89 -- Uncharacterized conserved protein R General function prediction only ; IPR001269 [tRNA-dihydrouridine synthase] -- -- Q61805 Lipopolysaccharide-binding protein Lbp 155.8 182.9 161.3 136 146.3 121.5 1.23823675086677 0.0430059976499021 0.308287184217976 Nonsignificant None 1 Molecular Function:lipid binding (GO:0008289) lipopolysaccharide-binding protein -- ko04064 NF-kappa B signaling pathway ko04620 Toll-like receptor signaling pathway ko05132 Salmonella infection ko05152 Tuberculosis BPI/LBP/CETP family protein V Defense mechanisms ; IPR001124 [Lipid-binding serum glycoprotein, C-terminal] ; IPR017942[Lipid-binding serum glycoprotein, N-terminal] -- -- Q3UI43 BRISC and BRCA1-A complex member 1 Babam1 244.9 235.4 266.8 283.7 270.7 279 0.896448284137269 0.0457387732322433 -0.157707738085712 Nonsignificant None -- -- BRISC and BRCA1-A complex member 1 -- ko03440 Homologous recombination -- -- -- -- -- -- Q3UHB1 5-nucleotidase domain-containing protein 3 Nt5dc3 212 222.7 159.9 194.4 212 205 0.97252208047105 0.793967508654148 -0.0401970889793258 Nonsignificant None -- -- -- -- -- Similar to IMP-GMP specific 5'-nucleotidase F Nucleotide transport and metabolism ; IPR008380 [HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase] -- -- Q8BSP6 Uncharacterized protein Ror2 118.5 109.7 94.2 110.1 90 99.7 1.07538358905937 0.457609705379341 0.104851360580108 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein binding (GO:0005515),Biological Process:protein phosphorylation (GO:0006468) receptor tyrosine kinase-like orphan receptor 2 2.7.10.1 -- Nerve growth factor receptor TRKA and related tyrosine kinases TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR000001 [Kringle] ; IPR001245[Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR013098[Immunoglobulin I-set] ; IPR020067[Frizzled domain] -- -- Q80U76 Ribosome biogenesis regulatory protein (Fragment) Rrs1 290.5 295.9 294.3 241 329.7 258.5 1.06210805595755 0.591722861909194 0.0869305494413366 Nonsignificant None 2 Cellular Component:nucleus (GO:0005634),Biological Process:ribosome biogenesis (GO:0042254) regulator of ribosome biosynthesis -- -- Regulator of ribosome synthesis J Translation, ribosomal structure and biogenesis ; IPR007023 [Ribosomal biogenesis regulatory protein] -- -- Q8R2R3 Alpha- and gamma-adaptin-binding protein p34 Aagab 238.1 217.3 233.8 240.8 244.9 230.8 0.961898115840893 0.297131157510583 -0.0560440029245598 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019341 [Alpha/gamma-adaptin-binding protein p34] -- -- A2ACH6 Delta-sarcoglycan Sgcd 280.8 315.1 307.4 433.9 374.6 406.9 0.743212111239098 0.00656058089167386 -0.428154083099226 Nonsignificant None 2 Cellular Component:sarcoglycan complex (GO:0016012),Cellular Component:integral component of membrane (GO:0016021) delta-sarcoglycan -- ko05410 Hypertrophic cardiomyopathy (HCM) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05414 Dilated cardiomyopathy (DCM) ko05416 Viral myocarditis Gamma/delta sarcoglycan Z Cytoskeleton ; IPR006875 [Sarcoglycan complex subunit protein] -- -- Q8K2Y7 39S ribosomal protein L47, mitochondrial Mrpl47 199.6 169.4 146.4 202.1 198 189.9 0.873559322033898 0.190992088808531 -0.195022417276946 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:mitochondrial ribosome (GO:0005761),Biological Process:translation (GO:0006412) large subunit ribosomal protein L47 -- -- Mitochondrial/chloroplast ribosomal protein L4/L29 J Translation, ribosomal structure and biogenesis ; IPR010729 [Ribosomal protein L47, mitochondrial] -- -- Q9WUB4 Dynactin subunit 6 Dctn6 342 350.7 373.9 371.4 405.2 389.3 0.914829745261172 0.07219120452789 -0.128424819820854 Nonsignificant None -- -- dynactin 6 -- ko04962 Vasopressin-regulated water reabsorption Dynactin subunit p27/WS-3, involved in transport of organelles along microtubules UZ Intracellular trafficking, secretion, and vesicular transport ; Cytoskeleton ; IPR001451 [Hexapeptide repeat] -- -- Q9JIK8 Nucleoside diphosphate kinase Ndk3 509.5 537.5 610 627.7 694.1 675.7 0.829536921151439 0.0341182824398224 -0.269621900593887 Nonsignificant None 5 Molecular Function:nucleoside diphosphate kinase activity (GO:0004550),Biological Process:nucleoside diphosphate phosphorylation (GO:0006165),Biological Process:GTP biosynthetic process (GO:0006183),Biological Process:UTP biosynthetic process (GO:0006228),Biological Process:CTP biosynthetic process (GO:0006241) nucleoside-diphosphate kinase 2.7.4.6 ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways Nucleoside diphosphate kinase F Nucleotide transport and metabolism ; IPR001564 [Nucleoside diphosphate kinase] -- -- D3Z7R7 Rho GTPase-activating protein 45 Arhgap45 128.3 129.8 131.3 110.5 126.6 95.9 1.16936936936937 0.166878278275632 0.22573070676167 Nonsignificant None 1 Biological Process:signal transduction (GO:0007165) Rho GTPase-activating protein 29/45 -- -- Chimaerin and related Rho GTPase activating proteins T Signal transduction mechanisms ; IPR000198 [Rho GTPase-activating protein domain] -- -- P70451 Tyrosine-protein kinase Fer Fer 251.8 235.1 244 251.6 242.7 226.6 1.01387154945207 0.723008034808591 0.0198748843855706 Nonsignificant None 2 Molecular Function:protein kinase activity (GO:0004672),Biological Process:protein phosphorylation (GO:0006468) tyrosine-protein kinase Fer 2.7.10.2 -- Protein tyrosine kinase T Signal transduction mechanisms ; IPR000980 [SH2 domain] ; IPR001060[FCH domain] ; IPR001245[Serine-threonine/tyrosine-protein kinase catalytic domain] -- -- Q3UC70 GTP cyclohydrolase 1 Gch1 368.1 367.4 388.2 348.8 414.6 352.3 1.00717038630456 0.911116919085554 0.0103077694248871 Nonsignificant None -- -- GTP cyclohydrolase IA 3.5.4.16 ko00790 Folate biosynthesis ko01100 Metabolic pathways GTP cyclohydrolase I H Coenzyme transport and metabolism ; IPR020602 [GTP cyclohydrolase I domain] -- -- Q3UZF0 DNA primase Prim1 143.4 159.6 154.7 129 131.9 127.2 1.1793352228807 0.00965446352915162 0.237973858815214 Nonsignificant None 1 Molecular Function:DNA primase activity (GO:0003896) DNA primase small subunit 2.7.7.- ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways ko03030 DNA replication Eukaryotic-type DNA primase, catalytic (small) subunit L Replication, recombination and repair ; IPR002755 [DNA primase, small subunit] -- -- P51163 Uroporphyrinogen-III synthase Uros 318 300.8 309.4 332.8 322.2 332.1 0.940330260358626 0.031209154709869 -0.0887605494796444 Nonsignificant None 2 Molecular Function:uroporphyrinogen-III synthase activity (GO:0004852),Biological Process:tetrapyrrole biosynthetic process (GO:0033014) uroporphyrinogen-III synthase 4.2.1.75 ko00860 Porphyrin and chlorophyll metabolism ko01100 Metabolic pathways Uroporphyrinogen III synthase UROS/HEM4 H Coenzyme transport and metabolism ; IPR003754 [Tetrapyrrole biosynthesis, uroporphyrinogen III synthase] -- -- Q4FK79 Translocon-associated protein subunit gamma Ssr3 179.3 183.7 199.5 211.3 205.2 209.5 0.898562300319489 0.0296485794959299 -0.154309560828219 Nonsignificant None 2 Biological Process:SRP-dependent cotranslational protein targeting to membrane (GO:0006614),Cellular Component:integral component of membrane (GO:0016021) translocon-associated protein subunit gamma -- ko04141 Protein processing in endoplasmic reticulum Translocon-associated complex TRAP, gamma subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR009779 [Translocon-associated protein subunit gamma] -- -- Q9JI44 DNA methyltransferase 1-associated protein 1 Dmap1 70.3 72.4 84.6 65.3 81 74 1.0317748524739 0.732439184183642 0.0451281891169647 Nonsignificant None 1 Cellular Component:nucleus (GO:0005634) DNA methyltransferase 1-associated protein 1 -- -- DNA methyltransferase 1-associated protein-1 BK Chromatin structure and dynamics ; Transcription ; IPR008468 [DNA methyltransferase 1-associated 1] ; IPR032563[DAMP1, SANT/Myb-like domain] -- -- Q3UII2 Tetraspanin Cd82 843.2 862.7 778.4 964.9 996.2 945.8 0.854621762014517 0.00871447480119585 -0.226642040739051 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) CD82 antigen -- ko04115 p53 signaling pathway Tetraspanin family integral membrane protein R General function prediction only ; IPR018499 [Tetraspanin/Peripherin] -- -- Q8CII2 Cell division cycle protein 123 homolog Cdc123 37.9 37.7 42.6 48.6 46.9 42.8 0.854663774403471 0.0463963232306848 -0.226571120972962 Nonsignificant None 1 Biological Process:cell cycle (GO:0007049) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR009772 [Cell division cycle protein 123] -- -- Q9D620 Rab11 family-interacting protein 1 Rab11fip1 61.6 69.4 77.2 89.4 85.2 79.2 0.820330969267139 0.0477977888480863 -0.285722000541689 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) Rab11 family-interacting protein 1/2/5 -- ko04144 Endocytosis -- -- -- IPR000008 [C2 domain] ; IPR019018[Rab-binding domain FIP-RBD] -- -- Q99K91 Rfc2 protein (Fragment) Rfc2 246.5 249.6 277.2 257.9 287.2 240.4 0.984468491406747 0.82043688896549 -0.0225830624717261 Nonsignificant None -- -- replication factor C subunit 2/4 -- ko03030 DNA replication ko03420 Nucleotide excision repair ko03430 Mismatch repair Replication factor C, subunit RFC2 L Replication, recombination and repair ; IPR013748 [Replication factor C, C-terminal] -- -- Q8BFU3 RING finger protein 214 Rnf214 147.7 156.7 153.3 143.1 131.9 140.3 1.10209487117746 0.0295963653561405 0.140248420175867 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- B9EID1 Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial Coq4 439.7 396.4 463 467.7 497.9 493.2 0.890526460104195 0.0697881418900613 -0.167269616301658 Nonsignificant None 1 Biological Process:ubiquinone biosynthetic process (GO:0006744) ubiquinone biosynthesis protein COQ4 -- -- Protein involved in ubiquinone biosynthesis H Coenzyme transport and metabolism ; IPR007715 [Ubiquinone biosynthesis protein Coq4] -- -- Q8BHY3 Anoctamin-1 Ano1 346.6 386.2 380.5 579.2 571.9 624.5 0.626999324172111 0.000427823699781106 -0.673464206906411 Significant down 1 Molecular Function:protein dimerization activity (GO:0046983) anoctamin-1 -- -- Uncharacterized conserved protein S Function unknown ; IPR007632 [Anoctamin] ; IPR032394[Anoctamin, dimerisation domain] -- -- O89050 Muskelin Mkln1 233.6 219.8 212.7 225.3 216 216.9 1.01200243087208 0.718797520965947 0.017212755450085 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Muskelin T Signal transduction mechanisms ; IPR006652 [Kelch repeat type 1] ; IPR010565[Muskelin, N-terminal] -- -- Q9JI39 ATP-binding cassette sub-family B member 10, mitochondrial Abcb10 229.1 208.5 205 234.7 220.1 243.8 0.919839679358717 0.141405819929379 -0.120545661923453 Nonsignificant None 5 Molecular Function:ATP binding (GO:0005524),Biological Process:transport (GO:0006810),Cellular Component:integral component of membrane (GO:0016021),Molecular Function:ATPase activity (GO:0016887),Biological Process:transmembrane transport (GO:0055085) ATP-binding cassette, subfamily B (MDR/TAP), member 10 -- ko02010 ABC transporters Peptide exporter, ABC superfamily U Intracellular trafficking, secretion, and vesicular transport ; IPR003439 [ABC transporter-like] ; IPR011527[ABC transporter type 1, transmembrane domain] -- -- Q99LL5 Periodic tryptophan protein 1 homolog Pwp1 142.2 141.4 132.2 157.3 135.8 138.1 0.964285714285714 0.533005079801904 -0.0524674198941357 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) periodic tryptophan protein 1 -- -- WD40 repeat-containing protein S Function unknown ; IPR001680 [WD40 repeat] -- -- Q91XM9 Disks large homolog 2 Dlg2 33.5 38 23.9 33.4 30.2 28.9 1.03135135135135 0.835685275867732 0.0445359006018372 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) discs large protein 2 -- ko04390 Hippo signaling pathway ko04530 Tight junction ko05165 Human papillomavirus infection Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) F Nucleotide transport and metabolism ; IPR001478 [PDZ domain] ; IPR008145[Guanylate kinase/L-type calcium channel beta subunit] ; IPR011511[Variant SH3 domain] ; IPR019583[PDZ-associated domain of NMDA receptors] ; IPR019590[Disks large homologue 1, N-terminal PEST domain] -- -- F8WI04 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (Fragment) Pgs1 570.6 672.8 476.1 451 469 444.5 1.26016855991206 0.170648829386296 0.33361672125265 Nonsignificant None -- -- CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase 2.7.8.5 ko00564 Glycerophospholipid metabolism ko01100 Metabolic pathways Phosphatidylglycerolphosphate synthase I Lipid transport and metabolism ; -- -- -- A0A0H2UKB7 Intraflagellar transport protein 22 homolog (Fragment) Ift22 9.8 9 9.9 11.4 15.8 10.6 0.759259259259259 0.138320889004733 -0.397335497545385 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) intraflagellar transport protein 22 -- -- -- -- -- IPR013684 [Mitochondrial Rho-like] -- -- S4R2L4 Arginine/serine-rich coiled-coil protein 2 Rsrc2 88.2 102 96.4 90.6 93.1 85.8 1.06345083487941 0.27797202332646 0.0887533366222778 Nonsignificant None -- -- -- -- -- -- -- -- IPR028124 [Small acidic protein-like domain] -- -- Q9D735 Telomerase RNA component interacting RNase Trir 500.4 581.8 607.8 476.7 505.3 447 1.18264520643807 0.0755121250767014 0.24201733007373 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q56A08 G-patch domain and KOW motifs-containing protein Gpkow 506.9 467.7 427 426.6 393 454.6 1.09998430387694 0.218760125601769 0.137482937494972 Nonsignificant None -- -- G patch domain and KOW motifs-containing protein -- -- G-patch nucleic acid binding protein R General function prediction only ; IPR005824 [KOW] ; IPR026822[Spp2/MOS2, G-patch domain] -- -- E9Q8D0 DnaJ homolog subfamily C member 21 Dnajc21 295.9 282.1 269.5 206.8 226.1 218.6 1.3008442056792 0.00231443767061944 0.379448189455572 Nonsignificant None -- -- DnaJ homolog subfamily A member 5 -- -- Molecular chaperone (DnaJ superfamily) O Posttranslational modification, protein turnover, chaperones ; IPR001623 [DnaJ domain] ; IPR022755[Zinc finger, double-stranded RNA binding] -- -- A0A140LIN0 WD repeat domain phosphoinositide-interacting protein 4 Wdr45 217.3 229.3 257.7 221.2 239.9 291.6 0.935698153314734 0.54183269623622 -0.0958848887409906 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein, contains WD40 repeats S Function unknown ; -- -- -- E9Q6W2 Cytochrome c oxidase assembly factor 3 homolog, mitochondrial Coa3 501.3 429 498.7 515.3 495.7 478.1 0.959640051037539 0.484012711055972 -0.0594347244304044 Nonsignificant None -- -- cytochrome c oxidase assembly factor 3, animal type -- -- Predicted membrane protein S Function unknown ; IPR018628 [Cytochrome c oxidase assembly factor 3, mitochondrial] -- -- Q5SVL6 Rap1 GTPase-activating protein 2 Rap1gap2 223.7 200.6 236.6 233.4 269.4 258.4 0.86823436678928 0.08939300137439 -0.203843565851983 Nonsignificant None 2 Molecular Function:GTPase activator activity (GO:0005096),Biological Process:regulation of small GTPase mediated signal transduction (GO:0051056) RAP1 GTPase activating protein 2 -- -- Rap1-GTPase-activating protein (Rap1GAP) T Signal transduction mechanisms ; IPR000331 [Rap GTPase activating protein domain] -- -- F8WI14 Extracellular matrix protein 1 Ecm1 385.3 403.9 335.2 324.4 349.6 329.5 1.12047832585949 0.13970237343328 0.164114742130364 Nonsignificant None 2 Cellular Component:extracellular region (GO:0005576),Biological Process:signal transduction (GO:0007165) -- -- -- -- -- -- IPR008605 [Extracellular matrix protein 1] -- -- P33174 Chromosome-associated kinesin KIF4 Kif4 185.8 190 145.3 113.6 108.2 110.2 1.56957831325301 0.0459790938789978 0.650377013197262 Significant up 4 Molecular Function:microtubule motor activity (GO:0003777),Molecular Function:ATP binding (GO:0005524),Biological Process:microtubule-based movement (GO:0007018),Molecular Function:microtubule binding (GO:0008017) kinesin family member 4/21/27 -- -- Kinesin-like protein Z Cytoskeleton ; IPR001752 [Kinesin motor domain] -- -- Q60989 E3 ubiquitin-protein ligase XIAP Xiap 187.5 177.3 156.9 159 161.9 154.3 1.09785353535354 0.169617360562494 0.134685597226977 Nonsignificant None -- -- E3 ubiquitin-protein ligase XIAP 2.3.2.27 ko01524 Platinum drug resistance ko04064 NF-kappa B signaling pathway ko04120 Ubiquitin mediated proteolysis ko04210 Apoptosis ko04215 Apoptosis - multiple species ko04217 Necroptosis ko04510 Focal adhesion ko04621 NOD-like receptor signaling pathway ko05145 Toxoplasmosis ko05166 HTLV-I infection ko05200 Pathways in cancer ko05222 Small cell lung cancer Apoptosis inhibitor IAP1 and related BIR domain proteins DR Cell cycle control, cell division, chromosome partitioning ; General function prediction only ; IPR001370 [BIR repeat] -- -- Q8K0G5 EARP and GARP complex-interacting protein 1 Eipr1 269.3 260.6 270.9 312.4 317.6 291.5 0.869017905588714 0.00943646645153403 -0.202542191682082 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- WD repeat protein TSSC1, WD repeat superfamily S Function unknown ; IPR001680 [WD40 repeat] -- -- E9Q4D0 Proprotein convertase subtilisin/kexin type 6 Pcsk6 97.4 87.9 74.5 76.5 96.2 85.1 1.0077579519007 0.942954114484676 0.0111491670862302 Nonsignificant None 3 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508),Molecular Function:peptidase activity (GO:0008233) proprotein convertase subtilisin/kexin type 6 3.4.21.- -- Subtilisin-like proprotein convertase O Posttranslational modification, protein turnover, chaperones ; IPR000209 [Peptidase S8/S53 domain] ; IPR002884[Proprotein convertase, P] ; IPR010909[PLAC] ; IPR032778[Growth factor receptor domain 4] ; IPR032815[Peptidase S8, pro-domain] -- -- Q8BM63 Uncharacterized protein (Fragment) Prkag2 166.9 164 162.1 226.9 199.1 207.3 0.778462024317069 0.00502052142452686 -0.361301432803038 Nonsignificant None -- -- 5'-AMP-activated protein kinase, regulatory gamma subunit -- ko04068 FoxO signaling pathway ko04152 AMPK signaling pathway ko04211 Longevity regulating pathway ko04213 Longevity regulating pathway - multiple species ko04371 Apelin signaling pathway ko04530 Tight junction ko04710 Circadian rhythm ko04910 Insulin signaling pathway ko04920 Adipocytokine signaling pathway ko04921 Oxytocin signaling pathway ko04922 Glucagon signaling pathway ko04931 Insulin resistance ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05410 Hypertrophic cardiomyopathy (HCM) 5'-AMP-activated protein kinase, gamma subunit C Energy production and conversion ; IPR000644 [CBS domain] -- -- A0A3B2WBC6 DNA-directed RNA polymerase II subunit GRINL1A Polr2m 18.4 31.9 9.1 41.5 37 19.7 0.604887983706721 0.239991267911368 -0.725260093513927 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- A0A286YCV0 Phospholipid-transporting ATPase Atp9b 91 82.1 97.8 113.8 100.8 110.8 0.832513829133374 0.0390381676419987 -0.264453857470514 Nonsignificant None 2 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:metal ion binding (GO:0046872) phospholipid-translocating ATPase 3.6.3.1 -- P-type ATPase P Inorganic ion transport and metabolism ; IPR008250 [P-type ATPase, A domain] ; IPR032630[P-type ATPase, C-terminal] ; IPR032631[P-type ATPase, N-terminal] -- -- Q8BJ05 Zinc finger CCCH domain-containing protein 14 Zc3h14 82 77.8 88.7 88.7 69 81.2 1.04018417748012 0.651200731478948 0.0568389979933161 Nonsignificant None -- -- -- -- -- Nuclear polyadenylated RNA binding protein A RNA processing and modification ; -- -- -- Q8C142 Low density lipoprotein receptor adapter protein 1 Ldlrap1 162.6 176.7 198.1 174.4 203.7 169.2 0.981911200438516 0.835500336084116 -0.0263355351943222 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) low density lipoprotein receptor adapter protein 1 -- ko04144 Endocytosis ko04979 Cholesterol metabolism Adaptor protein CED-6, contains PTB domain R General function prediction only ; IPR006020 [PTB/PI domain] -- -- Q80TL4 PHD finger protein 24 Phf24 195.3 202 191.5 243.8 229.3 233.3 0.83352208380521 0.00178525031973746 -0.262707671591453 Nonsignificant None -- -- -- -- -- -- -- -- IPR031946 [KIAA1045, RING finger] -- -- Q99J95 Cyclin-dependent kinase 9 Cdk9 54.6 47.8 55.5 50.7 47.5 51.5 1.05477621910488 0.371880232794138 0.0769369498018202 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) -- -- ko05202 Transcriptional misregulation in cancer Cyclin T-dependent kinase CDK9 D Cell cycle control, cell division, chromosome partitioning ; IPR000719 [Protein kinase domain] -- -- Q6ZQH5 MKIAA4250 protein (Fragment) Kctd5 280.5 260.7 259.4 238.3 221.5 255.1 1.11987690586096 0.0736811567532278 0.163340163476111 Nonsignificant None 1 Biological Process:protein homooligomerization (GO:0051260) BTB/POZ domain-containing protein KCTD2/5/17 -- -- Uncharacterized conserved protein, contains BTB/POZ domain R General function prediction only ; IPR003131 [Potassium channel tetramerisation-type BTB domain] -- -- Q8CB77 Elongin-A Eloa 914.9 897.7 646.2 578.8 593.2 600.1 1.3875063484002 0.118075549676317 0.472494372388537 Nonsignificant None 2 Cellular Component:nucleus (GO:0005634),Cellular Component:integral component of membrane (GO:0016021) transcription elongation factor B, polypeptide 3 -- -- RNA polymerase II transcription elongation factor Elongin/SIII, subunit elongin A K Transcription ; IPR010684 [RNA polymerase II transcription factor SIII, subunit A] ; IPR017923[Transcription factor IIS, N-terminal] -- -- Q6P8U6 Pancreatic triacylglycerol lipase Pnlip 208.5 190.9 213.2 189.9 669.6 227.6 0.563517615674731 0.412396690235537 -0.827467384845948 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) pancreatic triacylglycerol lipase 3.1.1.3 ko00561 Glycerolipid metabolism ko01100 Metabolic pathways ko04972 Pancreatic secretion ko04975 Fat digestion and absorption ko04977 Vitamin digestion and absorption -- -- -- IPR001024 [PLAT/LH2 domain] ; IPR013818[Lipase/vitellogenin] -- -- Q91V01 Lysophospholipid acyltransferase 5 Lpcat3 494.4 436.3 469 421.3 498.3 490.4 0.992695035460993 0.913482359968783 -0.0105775175189935 Nonsignificant None -- -- -- -- ko00564 Glycerophospholipid metabolism ko04216 Ferroptosis Predicted membrane protein S Function unknown ; IPR004299 [Membrane bound O-acyl transferase, MBOAT] -- -- O35405 5-3 exonuclease PLD3 Pld3 335.6 295.3 354.7 373.3 380.5 371.7 0.875699689027099 0.113516720624915 -0.191491895646617 Nonsignificant None 1 Molecular Function:catalytic activity (GO:0003824) phospholipase D3/4 3.1.4.4 ko00564 Glycerophospholipid metabolism ko00565 Ether lipid metabolism ko01100 Metabolic pathways Predicted phospholipase D R General function prediction only ; IPR001736 [Phospholipase D/Transphosphatidylase] ; IPR032803[PLD-like domain] -- -- Q9D7P6 Iron-sulfur cluster assembly enzyme ISCU, mitochondrial Iscu 405.3 423 533 485.4 478.2 507.6 0.925299075584557 0.421187140857186 -0.112008345340113 Nonsignificant None 3 Molecular Function:iron ion binding (GO:0005506),Biological Process:iron-sulfur cluster assembly (GO:0016226),Molecular Function:iron-sulfur cluster binding (GO:0051536) iron-sulfur cluster assembly enzyme ISCU, mitochondrial -- -- Iron binding protein involved in Fe-S cluster formation C Energy production and conversion ; IPR002871 [NIF system FeS cluster assembly, NifU, N-terminal] -- -- Q9Z223 Molybdopterin synthase catalytic subunit Mocs2 30.3 34.8 39 34 28.7 36.6 1.04833836858006 0.664475921404096 0.0681044457710433 Nonsignificant None 1 Biological Process:Mo-molybdopterin cofactor biosynthetic process (GO:0006777) molybdopterin synthase catalytic subunit 2.8.1.12 ko00790 Folate biosynthesis ko01100 Metabolic pathways ko04122 Sulfur relay system Molybdopterin converting factor subunit 2 H Coenzyme transport and metabolism ; IPR003448 [Molybdopterin biosynthesis MoaE] -- -- Q8BK35 Ribosome biogenesis protein NOP53 Nop53 76.7 70.3 78.9 60.6 78.2 57.9 1.14844941535333 0.229354246773222 0.199687313114554 Nonsignificant None -- -- nucleolar protein 53 -- ko05168 Herpes simplex infection Cellular protein (glioma tumor suppressor candidate region gene 2) R General function prediction only ; IPR011687 [Ribosome biogenesis protein Nop53/GLTSCR2] -- -- A0A1B0GR18 MOB kinase activator 2 Mob2 375.9 347.7 575.6 604.1 562.7 539.7 0.761324348080867 0.14112271829547 -0.393416876801052 Nonsignificant None -- -- -- -- -- Cell cycle-associated protein Mob1-1 D Cell cycle control, cell division, chromosome partitioning ; IPR005301 [MOB kinase activator family] -- -- O88574 Histone deacetylase complex subunit SAP30 Sap30 267.5 278.4 251.4 211.1 237.2 221.7 1.19 0.0176769611716568 0.250961573533219 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) histone deacetylase complex subunit SAP30 -- -- -- -- -- IPR025717 [Histone deacetylase complex subunit SAP30 zinc-finger] ; IPR025718[Histone deacetylase complex subunit SAP30, Sin3 binding domain] -- -- E9Q672 GTP-binding protein Rit1 Rit1 57 56.7 52.2 60.4 74 66.9 0.82414307004471 0.0490984576405559 -0.279033285965476 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-like without CAAX 1 -- -- Ras-related GTPase R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- A0A0R4J1H0 E3 ubiquitin-protein ligase MARCHF5 Marchf5 205.2 194.6 166.8 158.1 163.2 185.2 1.11865745310958 0.229782152281535 0.161768332689598 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) E3 ubiquitin-protein ligase MARCH5 2.3.2.27 -- Uncharacterized conserved protein S Function unknown ; IPR011016 [Zinc finger, RING-CH-type] -- -- Q9JK42 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Pdk2 123.2 131.8 121.2 146.5 160.8 154.5 0.814638371589433 0.00560971634835408 -0.29576832425092 Nonsignificant None -- -- pyruvate dehydrogenase kinase 2/3/4 2.7.11.2 -- Dehydrogenase kinase T Signal transduction mechanisms ; IPR003594 [Histidine kinase-like ATPase, C-terminal domain] ; IPR018955[Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal] -- -- E9QP44 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 Arap2 21.5 30.3 29.4 27.5 30 26.6 0.96551724137931 0.761495953759555 -0.0506260730699681 Nonsignificant None 3 Molecular Function:GTPase activator activity (GO:0005096),Molecular Function:protein binding (GO:0005515),Biological Process:signal transduction (GO:0007165) Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 -- ko04144 Endocytosis Rho- and Arf-GTPase activating protein ARAP3 TZ Signal transduction mechanisms ; Cytoskeleton ; IPR000159 [Ras-associating (RA) domain] ; IPR000198[Rho GTPase-activating protein domain] ; IPR001164[Arf GTPase activating protein] ; IPR001660[Sterile alpha motif domain] ; IPR001849[Pleckstrin homology domain] -- -- E0CYW1 Ubiquitin-like protein 5 (Fragment) Ubl5 1117.5 1129.5 954.5 907.1 950.2 924.1 1.15103904508521 0.0725977159415005 0.202936772823216 Nonsignificant None -- -- ubiquitin-like protein 5 -- Ubiquitin-like protein O Posttranslational modification, protein turnover, chaperones ; -- -- -- Q9JM62 Receptor expression-enhancing protein 6 Reep6 261.3 264.7 296.5 316.9 316.1 329.2 0.854811889420079 0.0177579111348935 -0.226321120572255 Nonsignificant None -- -- receptor expression-enhancing protein 5/6 -- -- Protein involved in membrane traffic (YOP1/TB2/DP1/HVA22 family) U Intracellular trafficking, secretion, and vesicular transport ; IPR004345 [TB2/DP1/HVA22-related protein] -- -- Q9JMA2 Queuine tRNA-ribosyltransferase catalytic subunit 1 Qtrt1 127.8 121.3 145.1 137 120.9 129.9 1.01650335224342 0.814062401936381 0.0236149729366932 Nonsignificant None 1 Biological Process:tRNA modification (GO:0006400) queuine tRNA-ribosyltransferase 2.4.2.29 -- Queuine-tRNA ribosyltransferase A RNA processing and modification ; IPR002616 [tRNA-guanine(15) transglycosylase-like] -- -- A2AA85 SUZ domain-containing protein 1 (Fragment) Szrd1 310.9 313.9 251.4 246.7 263.5 266 1.12883277505797 0.19155828336125 0.174831781537503 Nonsignificant None -- -- -- -- -- -- -- -- IPR024642 [SUZ-C domain] ; IPR024771[SUZ domain] -- -- A0A5F8MPP4 Ubiquitin carboxyl-terminal hydrolase 25 Usp25 259.5 271.5 303.1 273.3 289.4 246 1.03140843328799 0.665193559832976 0.0446157468617377 Nonsignificant None 2 Biological Process:protein deubiquitination (GO:0016579),Molecular Function:thiol-dependent ubiquitinyl hydrolase activity (GO:0036459) ubiquitin carboxyl-terminal hydrolase 25 3.4.19.12 ko04657 IL-17 signaling pathway Ubiquitin carboxyl-terminal hydrolase O Posttranslational modification, protein turnover, chaperones ; IPR001394 [Peptidase C19, ubiquitin carboxyl-terminal hydrolase] ; IPR003903[Ubiquitin interacting motif] -- -- Q2M4I9 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma Plcg1 359.1 350.1 170.6 200.1 200 201.6 1.46219046036231 0.270104354397637 0.54813124448027 Nonsignificant None 5 Molecular Function:phosphatidylinositol phospholipase C activity (GO:0004435),Molecular Function:protein binding (GO:0005515),Biological Process:lipid metabolic process (GO:0006629),Biological Process:signal transduction (GO:0007165),Biological Process:intracellular signal transduction (GO:0035556) phosphatidylinositol phospholipase C, gamma-1 3.1.4.11 ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko01521 EGFR tyrosine kinase inhibitor resistance ko04012 ErbB signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04020 Calcium signaling pathway ko04064 NF-kappa B signaling pathway ko04066 HIF-1 signaling pathway ko04070 Phosphatidylinositol signaling system ko04072 Phospholipase D signaling pathway ko04360 Axon guidance ko04370 VEGF signaling pathway ko04650 Natural killer cell mediated cytotoxicity ko04658 Th1 and Th2 cell differentiation ko04659 Th17 cell differentiation ko04660 T cell receptor signaling pathway ko04664 Fc epsilon RI signaling pathway ko04666 Fc gamma R-mediated phagocytosis ko04670 Leukocyte transendothelial migration ko04722 Neurotrophin signaling pathway ko04750 Inflammatory mediator regulation of TRP channels ko04919 Thyroid hormone signaling pathway ko04933 AGE-RAGE signaling pathway in diabetic complications ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05206 MicroRNAs in cancer ko05214 Glioma ko05223 Non-small cell lung cancer ko05225 Hepatocellular carcinoma ko05231 Choline metabolism in cancer Phospholipase C I Lipid transport and metabolism ; IPR000008 [C2 domain] ; IPR000909[Phosphatidylinositol-specific phospholipase C, X domain] ; IPR000980[SH2 domain] ; IPR001452[SH3 domain] ; IPR001711[Phospholipase C, phosphatidylinositol-specific, Y domain] -- -- Q80XS7 Protein FAM83E Fam83e 210.7 220.5 205.5 269.5 245.3 252.6 0.829684649465728 0.00660027886827902 -0.269365000718957 Nonsignificant None -- -- -- -- -- -- -- -- IPR012461 [Protein of unknown function DUF1669] -- -- Q9QXD8 LIM domain-containing protein 1 Limd1 277.5 267.1 292.1 277.2 268.1 286.4 1.00601178309487 0.861657006709767 0.00864720306886236 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) LIM domain-containing protein -- ko04390 Hippo signaling pathway ko04392 Hippo signaling pathway - multiple species Focal adhesion adaptor protein Paxillin and related LIM proteins T Signal transduction mechanisms ; IPR001781 [Zinc finger, LIM-type] -- -- Q8BMS9 Ras association domain-containing protein 2 Rassf2 216.8 228.5 226.7 211.7 177.6 211.3 1.11888111888112 0.115482615942668 0.162056758108973 Nonsignificant None 1 Biological Process:signal transduction (GO:0007165) Ras association domain-containing protein 2/4 -- ko04392 Hippo signaling pathway - multiple species Ras GTPase effector RASSF2 T Signal transduction mechanisms ; IPR000159 [Ras-associating (RA) domain] ; IPR011524[SARAH domain] -- -- Q8R3H7 Heparan sulfate 2-O-sulfotransferase 1 Hs2st1 190.1 174.7 168.4 144.3 165.6 158.3 1.13882956001709 0.0732813169155055 0.18755184597696 Nonsignificant None 2 Molecular Function:sulfotransferase activity (GO:0008146),Cellular Component:integral component of membrane (GO:0016021) heparan sulfate 2-O-sulfotransferase HS2ST1 2.8.2.- ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin Sulfotransferases O Posttranslational modification, protein turnover, chaperones ; IPR005331 [Sulfotransferase] -- -- J3QP43 Protein stum homolog Stum 195.2 168.3 155.5 175.4 196.3 175.9 0.947772096420745 0.52120792935123 -0.0773879080126563 Nonsignificant None -- -- -- -- -- -- -- -- IPR026673 [SPEC3/Stum] -- -- A2AAA9 C-type mannose receptor 2 Mrc2 219.3 217.3 234.9 236.7 265.9 230.5 0.915973264220434 0.169023150675926 -0.126622605887752 Nonsignificant None -- -- mannose receptor, C type -- ko04145 Phagosome ko05152 Tuberculosis C-type lectin TV Signal transduction mechanisms ; Defense mechanisms ; IPR000562 [Fibronectin, type II, collagen-binding] ; IPR001304[C-type lectin-like] -- -- Q6PAM0 5-AMP-activated protein kinase subunit beta-2 Prkab2 66.6 61.9 88.2 94 85 94 0.793772893772894 0.0954717243726064 -0.333201797713541 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) 5'-AMP-activated protein kinase, regulatory beta subunit -- ko04068 FoxO signaling pathway ko04152 AMPK signaling pathway ko04211 Longevity regulating pathway ko04213 Longevity regulating pathway - multiple species ko04371 Apelin signaling pathway ko04530 Tight junction ko04710 Circadian rhythm ko04910 Insulin signaling pathway ko04920 Adipocytokine signaling pathway ko04921 Oxytocin signaling pathway ko04922 Glucagon signaling pathway ko04931 Insulin resistance ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05410 Hypertrophic cardiomyopathy (HCM) Protein involved in Snf1 protein kinase complex assembly G Carbohydrate transport and metabolism ; IPR006828 [Association with the SNF1 complex (ASC) domain] ; IPR032640[AMP-activated protein kinase, glycogen-binding domain] -- -- Q99J39 Malonyl-CoA decarboxylase, mitochondrial Mlycd 265.8 241.2 265.4 282.7 283.4 284 0.908598988354311 0.085775476564178 -0.13828439580685 Nonsignificant None 2 Biological Process:fatty acid biosynthetic process (GO:0006633),Molecular Function:malonyl-CoA decarboxylase activity (GO:0050080) malonyl-CoA decarboxylase 4.1.1.9 ko00410 beta-Alanine metabolism ko00640 Propanoate metabolism ko01100 Metabolic pathways ko04146 Peroxisome ko04152 AMPK signaling pathway Malonyl-CoA decarboxylase G Carbohydrate transport and metabolism ; IPR007956 [Malonyl-CoA decarboxylase] -- -- Q9JKK7 Tropomodulin-2 Tmod2 25.7 23.4 29.9 26.7 39.4 31.1 0.812757201646091 0.220439767360636 -0.299103660541316 Nonsignificant None 2 Molecular Function:tropomyosin binding (GO:0005523),Biological Process:pointed-end actin filament capping (GO:0051694) tropomodulin -- -- Tropomodulin and leiomodulin Z Cytoskeleton ; IPR004934 [Tropomodulin] -- -- Q60977 Tumor-associated glycoprotein E4 Pvr 143.6 126.6 129.1 152.4 146.1 142.3 0.905852994555354 0.084630841097974 -0.14265115193811 Nonsignificant None -- -- poliovirus receptor -- ko04514 Cell adhesion molecules (CAMs) -- -- -- IPR013106 [Immunoglobulin V-set domain] ; IPR013162[CD80-like, immunoglobulin C2-set] -- -- Q8K215 LYR motif-containing protein 4 Lyrm4 463.5 427.1 573.7 521.8 519.4 576.5 0.905174012486864 0.345471835336367 -0.143732929410395 Nonsignificant None -- -- LYR motif-containing protein 4 -- -- Uncharacterized conserved protein BCN92 A RNA processing and modification ; IPR008011 [Complex 1 LYR protein] -- -- Q8K4F5 Protein ABHD11 Abhd11 94.7 102.1 90.4 119.1 134.1 117.6 0.774541531823085 0.011350159941425 -0.368585494802479 Nonsignificant None -- -- abhydrolase domain-containing protein 11 -- -- Predicted alpha/beta hydrolase R General function prediction only ; IPR000073 [Alpha/beta hydrolase fold-1] -- -- Q9CQ49 Nuclear cap-binding protein subunit 2 Ncbp2 393.2 385.3 402.8 376.7 384.9 355.6 1.05737558181167 0.101563467336466 0.0804879157675918 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) nuclear cap-binding protein subunit 2 -- ko03013 RNA transport ko03015 mRNA surveillance pathway ko03040 Spliceosome Nuclear cap-binding protein complex, subunit CBP20 (RRM superfamily) A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- Q8VE11 Myotubularin-related protein 6 Mtmr6 115.5 115.1 95.9 130.3 141.9 130.4 0.810978638847491 0.028040398834164 -0.302264180487547 Nonsignificant None -- -- -- -- ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system Myotubularin-related phosphatidylinositol 3-phosphate 3-phosphatase MTM6 R General function prediction only ; IPR010569 [Myotubularin-like phosphatase domain] -- -- Q91WK5 Glycine cleavage system H protein, mitochondrial Gcsh 1053.3 1111.2 1175.4 1222.2 1126.1 1127.2 0.960984031074665 0.395361190137315 -0.0574156373335022 Nonsignificant None -- -- glycine cleavage system H protein -- ko00260 Glycine, serine and threonine metabolism ko00630 Glyoxylate and dicarboxylate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism Glycine cleavage system H protein (lipoate-binding) E Amino acid transport and metabolism ; IPR033753 [Glycine cleavage system H-protein/Simiate] -- -- G5E8V8 Phosphorylated adapter RNA export protein Phax 499.3 515.5 499.5 476.7 466.3 465.7 1.07496273159651 0.00546862880583495 0.104286643188758 Nonsignificant None -- -- phosphorylated adapter RNA export protein -- ko03013 RNA transport Mediator of U snRNA nuclear export PHAX A RNA processing and modification ; IPR019385 [Phosphorylated adapter RNA export protein, RNA-binding domain] -- -- Q8K2T2 Ribonuclease, RNase A family, 1 (Pancreatic) Rnase1 548.8 684.1 362.9 358.6 425.4 367.9 1.38536331278757 0.195914987337428 0.47026437397956 Nonsignificant None -- -- pancreatic ribonuclease 3.1.27.5 -- -- -- -- IPR023412 [Ribonuclease A-domain] -- -- Q9D8K1 Uncharacterized protein 1810065E05Rik 577.9 597.6 1468.8 908.5 838.9 882 1.00566669202099 0.988060325762738 0.00815223213590937 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q91VX9 Transmembrane protein 168 Tmem168 179.2 175.4 174.2 233 262.9 236.6 0.721911262798635 0.0167594564305773 -0.470106582689281 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q6TEK5 Vitamin K epoxide reductase complex subunit 1-like protein 1 Vkorc1l1 72.3 63.5 114 146.3 151.8 137.3 0.573725310059715 0.0185624200481781 -0.801567930580249 Significant down -- -- vitamin-K-epoxide reductase (warfarin-sensitive) 1.17.4.4 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis -- -- -- IPR012932 [Vitamin K epoxide reductase] -- -- Q91Z49 UAP56-interacting factor Fyttd1 274.1 258.5 258.3 289.2 279.3 284.7 0.926980778246601 0.0253191849947089 -0.109388671263976 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q5U430 E3 ubiquitin-protein ligase UBR3 Ubr3 80.4 91.2 52.8 99.5 102.7 100.6 0.74108322324967 0.148717446805571 -0.432292529376939 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) E3 ubiquitin-protein ligase UBR3 2.3.2.27 -- Predicted ubiquitin-protein ligase of the N-recognin family O Posttranslational modification, protein turnover, chaperones ; IPR003126 [Zinc finger, UBR-type] -- -- Q9Z0X4 cGMP-inhibited 3,5-cyclic phosphodiesterase 3A Pde3a 331.2 316 402.5 435.1 422.1 392.4 0.84002880921895 0.086847210180926 -0.251489288180974 Nonsignificant None 2 Molecular Function:3',5'-cyclic-nucleotide phosphodiesterase activity (GO:0004114),Biological Process:signal transduction (GO:0007165) cGMP-inhibited 3',5'-cyclic phosphodiesterase A 3.1.4.17 ko00230 Purine metabolism ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04924 Renin secretion ko05032 Morphine addiction -- -- -- IPR002073 [3'5'-cyclic nucleotide phosphodiesterase, catalytic domain] -- -- Q8CH25 SAFB-like transcription modulator Sltm 149.6 150.1 145.3 179.9 159.2 169.1 0.875639512003148 0.0268992812547071 -0.191591039312232 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- -- -- -- IPR000504 [RNA recognition motif domain] ; IPR003034[SAP domain] -- -- Q059U0 1-acyl-sn-glycerol-3-phosphate acyltransferase Agpat2 307.6 291 281.1 235.3 220.6 258 1.23224541252276 0.0143631503250521 0.301289610067386 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) lysophosphatidate acyltransferase 2.3.1.51 ko00561 Glycerolipid metabolism ko00564 Glycerophospholipid metabolism ko01100 Metabolic pathways ko04072 Phospholipase D signaling pathway ko04975 Fat digestion and absorption 1-acyl-sn-glycerol-3-phosphate acyltransferase I Lipid transport and metabolism ; IPR002123 [Phospholipid/glycerol acyltransferase] -- -- Q8C0J2 Autophagy-related protein 16-1 Atg16l1 56.7 67.6 74.2 77.1 78.2 79.8 0.844321565291365 0.136225607548215 -0.244135531622701 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) autophagy-related protein 16-1 -- ko04136 Autophagy - other ko04140 Autophagy - animal ko04621 NOD-like receptor signaling pathway WD40 repeat protein TipD R General function prediction only ; IPR001680 [WD40 repeat] ; IPR013923[Autophagy-related protein 16] -- -- Q3UBB0 Sulfatase domain-containing protein (Fragment) Gns 348.3 339.9 405.3 443.3 430.4 417.5 0.846886617100372 0.0393275327935654 -0.239759263342325 Nonsignificant None 2 Biological Process:metabolic process (GO:0008152),Molecular Function:sulfuric ester hydrolase activity (GO:0008484) N-acetylglucosamine-6-sulfatase 3.1.6.14 ko00531 Glycosaminoglycan degradation ko01100 Metabolic pathways ko04142 Lysosome Sulfatases G Carbohydrate transport and metabolism ; IPR000917 [Sulfatase, N-terminal] -- -- Q3UQQ4 RNA helicase Dhx8 15.7 16.4 6.6 14.7 13.4 14.6 0.90632318501171 0.714856342271283 -0.14190250347608 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:helicase activity (GO:0004386) ATP-dependent RNA helicase DHX8/PRP22 3.6.4.13 ko03040 Spliceosome DEAH-box RNA helicase A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR003029[S1 domain] ; IPR007502[Helicase-associated domain] ; IPR011709[Domain of unknown function DUF1605] -- -- A2AQ19 RNA polymerase-associated protein RTF1 homolog Rtf1 380.9 486.3 471.5 406.2 407.6 418.2 1.08660714285714 0.393260716271675 0.119830435768762 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) RNA polymerase-associated protein RTF1 -- -- Paf1/RNA polymerase II complex, RTF1 component (involved in regulation of TATA box-binding protein) K Transcription ; IPR004343 [Plus-3 domain] -- -- Q3TAR6 Protein kinase domain-containing protein Vrk3 113.3 99.4 107.2 121.3 121.8 113.5 0.897083567021873 0.064746553587809 -0.156685710509321 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) vaccinia related kinase 2.7.11.1 -- Casein kinase (serine/threonine/tyrosine protein kinase) T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- A0A494B9Y8 Ferrochelatase Fech 406.5 396.6 439.6 501.1 550.2 547.9 0.777076038019009 0.00449359489266152 -0.363872319541851 Nonsignificant None 2 Molecular Function:ferrochelatase activity (GO:0004325),Biological Process:heme biosynthetic process (GO:0006783) -- -- ko00860 Porphyrin and chlorophyll metabolism ko01100 Metabolic pathways Protoheme ferro-lyase (ferrochelatase) H Coenzyme transport and metabolism ; IPR001015 [Ferrochelatase] -- -- Q0VGR5 CDK5 regulatory subunit associated protein 2 Cdk5rap2 198.1 177.9 116.2 134.3 159.9 136.5 1.1427908056652 0.473888519678238 0.192561334216301 Nonsignificant None 1 Cellular Component:microtubule organizing center (GO:0005815) CDK5 regulatory subunit-associated protein 2 -- -- -- -- -- IPR012943 [Centrosomin, N-terminal motif 1] -- -- Q9ERD8 Gamma-parvin Parvg 42.6 60 42 33.4 38.3 36.7 1.33394833948339 0.118007099966486 0.415702795597246 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) parvin -- ko04510 Focal adhesion Alpha-parvin and related focal adhesion proteins Z Cytoskeleton ; IPR001715 [Calponin homology domain] -- -- Q8BZG8 PDZ domain-containing protein Sntg2 392.2 437.4 430.8 480.9 508.6 462 0.868343093351705 0.0310814942352616 -0.203662912496484 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Syntrophins (type gamma) W Extracellular structures ; IPR001478 [PDZ domain] -- -- A0A0R4J0R1 Vesicle-associated membrane protein 8 Vamp8 414.8 403.4 370.4 377.9 417.7 398.7 0.995227329816629 0.919174658452782 -0.00690199120186296 Nonsignificant None 2 Cellular Component:integral component of membrane (GO:0016021),Biological Process:vesicle-mediated transport (GO:0016192) vesicle-associated membrane protein 8 -- ko04130 SNARE interactions in vesicular transport ko04140 Autophagy - animal ko04611 Platelet activation Synaptobrevin/VAMP-like protein U Intracellular trafficking, secretion, and vesicular transport ; IPR001388 [Synaptobrevin] -- -- Q9D2N9 Vacuolar protein sorting-associated protein 33A Vps33a 113.1 154.7 162.1 195.6 182.5 131.9 0.842941176470588 0.340419075482387 -0.246496136762919 Nonsignificant None 2 Biological Process:vesicle docking involved in exocytosis (GO:0006904),Biological Process:vesicle-mediated transport (GO:0016192) vacuolar protein sorting-associated protein 33 -- Vacuolar sorting protein VPS33/slp1 (Sec1 family) U Intracellular trafficking, secretion, and vesicular transport ; IPR001619 [Sec1-like protein] -- -- P40201 Chromodomain-helicase-DNA-binding protein 1 Chd1 170.7 211 162.7 168.3 188.2 160.5 1.05299806576402 0.620980462102875 0.0745027863016977 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) chromodomain-helicase-DNA-binding protein 1 3.6.4.12 -- Chromodomain-helicase DNA-binding protein K Transcription ; IPR000330 [SNF2-related, N-terminal domain] ; IPR001650[Helicase, C-terminal] ; IPR023780[Chromo domain] ; IPR025260[Domain of unknown function DUF4208] -- -- Q8BWM3 Stefin A2-like 1 Stfa2l1 427 635.1 568.2 145.9 128.4 131.5 4.01749630359783 0.0211614056985192 2.00629669651181 Significant up 1 Molecular Function:cysteine-type endopeptidase inhibitor activity (GO:0004869) -- -- -- -- -- -- IPR000010 [Cystatin domain] -- -- A2CF65 C-type lectin domain family 10 member A (Fragment) Clec10a 74.9 65.2 79.1 88.3 75.4 89.5 0.865718799368088 0.137128254698297 -0.208029606467815 Nonsignificant None -- -- C-type lectin domain family 10 member A -- -- C-type lectin TV Signal transduction mechanisms ; Defense mechanisms ; IPR001304 [C-type lectin-like] ; IPR005640[Hepatic lectin, N-terminal] -- -- Q9CR39 WD repeat domain phosphoinositide-interacting protein 3 Wdr45b 542.6 538.9 493.5 489.3 515.2 495.2 1.0502100420084 0.227512288182112 0.0706778957573241 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein, contains WD40 repeats S Function unknown ; -- -- -- Q545H3 Mitochondrial import inner membrane translocase subunit TIM17 Timm17b 139.8 128.7 126.7 114.2 132.1 139.6 1.02409950764447 0.73572516251001 0.0343559030434235 Nonsignificant None -- -- mitochondrial import inner membrane translocase subunit TIM17 -- -- Mitochondrial import inner membrane translocase, subunit TIM17 U Intracellular trafficking, secretion, and vesicular transport ; IPR003397 [Mitochondrial inner membrane translocase subunit Tim17/Tim22/Tim23/peroxisomal protein PMP24] -- -- A0A494BAY0 Vacuolar protein sorting-associated protein 37C (Fragment) Vps37c 68.3 60.4 64.6 55.8 64.8 67.5 1.02764486975013 0.701602446650944 0.0393417886880408 Nonsignificant None -- -- ESCRT-I complex subunit VPS37 -- ko04144 Endocytosis Uncharacterized conserved protein S Function unknown ; IPR009851 [Modifier of rudimentary, Modr] -- -- P27641 X-ray repair cross-complementing protein 5 Xrcc5 384.4 325.3 305 385.9 380.7 376 0.888062314020655 0.213947390819983 -0.171267182980424 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Molecular Function:ATP-dependent DNA helicase activity (GO:0004003),Biological Process:double-strand break repair via nonhomologous end joining (GO:0006303) ATP-dependent DNA helicase 2 subunit 2 -- ko03450 Non-homologous end-joining DNA-binding subunit of a DNA-dependent protein kinase (Ku80 autoantigen) L Replication, recombination and repair ; IPR005160 [Ku70/Ku80 C-terminal arm] ; IPR005161[Ku70/Ku80, N-terminal alpha/beta] ; IPR006164[Ku70/Ku80 beta-barrel domain] ; IPR014893[Ku, C-terminal] -- -- Q91XF0 Pyridoxine-5-phosphate oxidase Pnpo 452.3 462.9 580.6 629.7 639 572.3 0.812493210211842 0.0670577716009684 -0.299572338024612 Nonsignificant None 3 Molecular Function:pyridoxamine-phosphate oxidase activity (GO:0004733),Molecular Function:FMN binding (GO:0010181),Biological Process:oxidation-reduction process (GO:0055114) pyridoxamine 5'-phosphate oxidase 1.4.3.5 ko00750 Vitamin B6 metabolism ko01100 Metabolic pathways Pyridoxamine-phosphate oxidase H Coenzyme transport and metabolism ; IPR011576 [Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain] ; IPR019576[Pyridoxine 5'-phosphate oxidase, dimerisation, C-terminal] -- -- F6YTL8 YLP motif-containing protein 1 (Fragment) Ylpm1 43.6 44.1 47.5 47.4 39.2 42.7 1.04563031709203 0.502681037424387 0.06437287647193 Nonsignificant None -- -- YLP motif-containing protein 1 -- -- Nuclear protein ZAP V Defense mechanisms ; -- -- -- Q9CZL2 Uncharacterized protein FAM241A Fam241a 18.6 15.2 17.9 22 16.6 16.5 0.938294010889292 0.616723705858889 -0.091888038256223 Nonsignificant None -- -- -- -- -- -- -- -- IPR027953 [Domain of unknown function DUF4605] -- -- Q8C5W3 Tubulin-specific chaperone cofactor E-like protein Tbcel 482.8 533 518.2 485.4 506.9 521.2 1.01354476379253 0.725910527916487 0.01940980767542 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR000626 [Ubiquitin domain] -- -- A0A286YCS7 LIM and senescent cell antigen-like-containing domain protein 2 (Fragment) Lims2 189.6 183.1 298.1 315.7 318.1 313.7 0.707968337730871 0.1317611307657 -0.49824325438147 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) -- -- -- Focal adhesion protein PINCH-1, contains LIM domains TZ Signal transduction mechanisms ; Cytoskeleton ; IPR001781 [Zinc finger, LIM-type] -- -- Q8BLR9 Hypoxia-inducible factor 1-alpha inhibitor Hif1an 179.3 230.8 255.5 280.1 248.2 234.5 0.872574724698479 0.283824716266865 -0.196649410171664 Nonsignificant None -- -- hypoxia-inducible factor 1-alpha inhibitor (HIF hydroxylase) 1.14.11.30 -- Uncharacterized conserved protein, contains JmjC domain BT Chromatin structure and dynamics ; Signal transduction mechanisms ; -- -- -- E9Q166 ATPase family, AAA domain-containing 2B Atad2b 149.5 138.1 134.9 138.6 115.2 141.3 1.06934953176411 0.386110771731685 0.0967334950792385 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524) AAA+-type ATPase containing the bromodomain O Posttranslational modification, protein turnover, chaperones ; IPR001487 [Bromodomain] ; IPR003959[ATPase, AAA-type, core] -- -- Q62266 Cornifin-A Sprr1a 601 657.7 538.5 364.5 370.6 330.8 1.68608687494136 0.00263464869161148 0.75367887247106 Significant up -- -- -- -- -- -- -- -- -- -- -- A0A0U1RPG8 Potassium channel tetramerisation domain-containing 14 Kctd14 222 208.7 168.1 210.2 195.2 202.9 0.984382705901693 0.859500268928347 -0.0227087828135875 Nonsignificant None 1 Biological Process:protein homooligomerization (GO:0051260) BTB/POZ domain-containing protein KCTD7/14 -- -- Uncharacterized conserved protein, contains BTB/POZ domain R General function prediction only ; IPR003131 [Potassium channel tetramerisation-type BTB domain] -- -- Q8CG71 Prolyl 3-hydroxylase 2 P3h2 377.6 391.2 462.1 446.1 470.1 414 0.925349571493009 0.343401938891294 -0.111929615974772 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) Membrane-associated proteoglycan Leprecan S Function unknown ; IPR005123 [Oxoglutarate/iron-dependent dioxygenase] -- -- Q8CIM8 Integrator complex subunit 4 Ints4 139.1 150.3 144.8 137.2 135.1 146 1.03801099689218 0.317795100352751 0.0538217279711093 Nonsignificant None -- -- integrator complex subunit 4 -- -- Uncharacterized conserved protein S Function unknown ; IPR026003 [HEAT repeat associated with sister chromatid cohesion protein] -- -- E9Q933 Transmembrane protein 11, mitochondrial Tmem11 276.4 265.1 296.5 245.5 284.5 278.3 1.03674378324879 0.550103565908615 0.0520593962643457 Nonsignificant None 2 Biological Process:mitochondrion organization (GO:0007005),Cellular Component:integral component of mitochondrial inner membrane (GO:0031305) -- -- -- -- -- -- IPR026120 [Transmembrane protein 11] -- -- Q3TIB7 Gamma-tubulin complex component Tubgcp2 175.1 157.1 172.8 168.3 173.3 169.9 0.987292277614858 0.729655539135631 -0.0184508521061715 Nonsignificant None 5 Biological Process:microtubule cytoskeleton organization (GO:0000226),Cellular Component:spindle pole (GO:0000922),Cellular Component:microtubule organizing center (GO:0005815),Biological Process:microtubule nucleation (GO:0007020),Molecular Function:gamma-tubulin binding (GO:0043015) gamma-tubulin complex component 2 -- -- Gamma-tubulin complex, DGRIP84/SPC97 component Z Cytoskeleton ; IPR007259 [Gamma-tubulin complex component protein] -- -- Q80Z96 Vang-like protein 1 Vangl1 35.4 28.7 31.6 34 35.9 31.8 0.941002949852507 0.428610385425898 -0.0877288493714746 Nonsignificant None 2 Biological Process:multicellular organism development (GO:0007275),Cellular Component:integral component of membrane (GO:0016021) vang-like -- ko04310 Wnt signaling pathway Signaling protein van gogh/strabismus T Signal transduction mechanisms ; IPR009539 [Vang-like protein] -- -- Q9JMA9 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) Slc6a14 404.1 413.6 634.1 520.8 508.2 488.7 0.956579034064703 0.798301121267234 -0.064043923657597 Nonsignificant None 3 Molecular Function:neurotransmitter:sodium symporter activity (GO:0005328),Biological Process:neurotransmitter transport (GO:0006836),Cellular Component:integral component of membrane (GO:0016021) solute carrier family 6 (neurotransmitter transporter, amino acid) member 5/7/9/14 -- -- Sodium-neurotransmitter symporter T Signal transduction mechanisms ; IPR000175 [Sodium:neurotransmitter symporter] -- -- P26011 Integrin beta-7 Itgb7 94.2 78.5 69.5 86.7 75.6 82.3 0.990188062142273 0.924268151358542 -0.0142255388330578 Nonsignificant None -- -- integrin beta 7 -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04514 Cell adhesion molecules (CAMs) ko04672 Intestinal immune network for IgA production ko04810 Regulation of actin cytoskeleton ko05165 Human papillomavirus infection ko05202 Transcriptional misregulation in cancer ko05410 Hypertrophic cardiomyopathy (HCM) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05414 Dilated cardiomyopathy (DCM) Integrin beta subunit (N-terminal portion of extracellular region) TW Signal transduction mechanisms ; Extracellular structures ; IPR002369 [Integrin beta subunit, VWA domain] ; IPR013111[EGF-like domain, extracellular] ; IPR014836[Integrin beta subunit, cytoplasmic domain] ; IPR033760[Integrin beta N-terminal] -- -- B2RUG7 Zinc finger RNA binding protein Zfr 258.8 268.9 200 208.8 233.9 217.7 1.1019079345851 0.379045827372973 0.140003690455285 Nonsignificant None -- -- zinc finger RNA-binding protein -- -- Transcription factor NFAT, subunit NF90 R General function prediction only ; IPR006561 [DZF domain] -- -- Q99N92 39S ribosomal protein L27, mitochondrial Mrpl27 425.9 405.3 377 381.2 387.7 357.7 1.07243032132079 0.18178650324944 0.100883914997011 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L27 -- ko03010 Ribosome Mitochondrial ribosomal protein MRP7 (L2) J Translation, ribosomal structure and biogenesis ; IPR001684 [Ribosomal protein L27] -- -- Q3TUK6 mRNA-capping enzyme Rngtt 387.7 345.5 352.8 360.7 366.5 377.5 0.983072327328686 0.677533791986669 -0.0246305313837633 Nonsignificant None 5 Molecular Function:mRNA guanylyltransferase activity (GO:0004484),Biological Process:7-methylguanosine mRNA capping (GO:0006370),Biological Process:mRNA processing (GO:0006397),Biological Process:protein dephosphorylation (GO:0006470),Molecular Function:protein tyrosine/serine/threonine phosphatase activity (GO:0008138) -- -- ko03015 mRNA surveillance pathway mRNA capping enzyme, guanylyltransferase (alpha) subunit A RNA processing and modification ; IPR000340 [Dual specificity phosphatase, catalytic domain] ; IPR001339[mRNA capping enzyme, catalytic domain] -- -- Q4QQP1 COMM domain containing 8 Commd8 345.9 332.9 363.2 385.9 433.5 375.7 0.871893565392017 0.0619713964027818 -0.197776063157004 Nonsignificant None -- -- -- -- -- -- -- -- IPR017920 [COMM domain] -- -- Q5BKS5 Hook homolog 3 (Drosophila) Hook3 154.3 291.9 316.8 360.9 362.5 278.7 0.761401057778665 0.238733095872053 -0.393271520717455 Nonsignificant None -- -- protein HOOK3 -- -- -- -- -- IPR008636 [Hook-related protein family] -- -- D3Z723 Nuclear transcription factor Y subunit beta (Fragment) Nfyb 350.5 332.2 325 321.2 314.1 322.9 1.05165936130244 0.109868547730795 0.0726674828232659 Nonsignificant None -- -- nuclear transcription Y subunit beta -- ko04612 Antigen processing and presentation ko05152 Tuberculosis ko05166 HTLV-I infection CCAAT-binding factor, subunit A (HAP3) K Transcription ; IPR003958 [Transcription factor CBF/NF-Y/archaeal histone domain] -- NF-YB Q8CG70 Prolyl 3-hydroxylase 3 P3h3 290.6 256.8 312.9 298 271.4 262.1 1.03463619963921 0.648886629898063 0.0491235742556342 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) Membrane-associated proteoglycan Leprecan S Function unknown ; IPR005123 [Oxoglutarate/iron-dependent dioxygenase] -- -- Q91WA6 Sharpin Sharpin 17.2 13.2 17.6 14 11.6 16 1.15384615384615 0.323241691455692 0.206450877467426 Nonsignificant None -- -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR031912 [Sharpin, PH domain] -- -- P70279 Surfeit locus protein 6 Surf6 604.1 592 585.8 524.3 599.5 558.2 1.05939357907253 0.211276888095338 0.0832386696774366 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR029190 [Ribosomal RNA-processing protein 14/surfeit locus protein 6, C-terminal domain] -- -- Q9DC33 High mobility group protein 20A Hmg20a 166.6 143.4 149.2 137 143 158.1 1.04816251997261 0.49507333999791 0.0678624273527372 Nonsignificant None -- -- -- -- -- HMG box-containing protein R General function prediction only ; IPR009071 [High mobility group box domain] -- HMG Q9Z260 Claudin-8 Cldn8 44.1 44.4 40.9 52.1 48.4 47.1 0.876693766937669 0.0315602525233325 -0.189855104067889 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) claudin -- ko04514 Cell adhesion molecules (CAMs) ko04530 Tight junction ko04670 Leukocyte transendothelial migration ko05160 Hepatitis C -- -- -- IPR004031 [PMP-22/EMP/MP20/Claudin superfamily] -- -- Q91VR7 Microtubule-associated proteins 1A/1B light chain 3A Map1lc3a 257.8 246 208 214.1 226.9 242.3 1.04170935167569 0.607993364867327 0.0589528060351473 Nonsignificant None -- -- microtubule-associated protein 1 light chain -- ko04216 Ferroptosis Microtubule-associated anchor protein involved in autophagy and membrane trafficking Z Cytoskeleton ; IPR004241 [Autophagy protein Atg8 ubiquitin-like] -- -- Q9D0L4 AarF domain-containing protein kinase 1 Adck1 58.6 41.9 37.9 47.8 44.9 41.4 1.03206562266965 0.838794767566137 0.0455347057322509 Nonsignificant None -- -- aarF domain-containing kinase -- -- Predicted unusual protein kinase R General function prediction only ; IPR004147 [UbiB domain] -- -- D3Z2M0 Cytoplasmic tRNA 2-thiolation protein 2 (Fragment) Ctu2 25.8 24.5 36.3 33.6 38.6 36.8 0.794495412844037 0.136193723934 -0.331889204937564 Nonsignificant None -- -- cytoplasmic tRNA 2-thiolation protein 2 -- ko04122 Sulfur relay system -- -- -- -- -- -- Q8VBZ0 Dehydrogenase/reductase SDR family member on chromosome X homolog Dhrsx 41.1 36.2 40.7 31.1 34 36 1.16716122650841 0.0564959704141928 0.223003862346189 Nonsignificant None -- -- dehydrogenase/reductase SDR family member X 1.1.-.- -- Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Q Secondary metabolites biosynthesis, transport and catabolism ; IPR002347 [Short-chain dehydrogenase/reductase SDR] -- -- B1ASP2 Tyrosine-protein kinase Jak1 143.8 136.1 163.5 158.5 159.9 154.2 0.938214134574693 0.307857497657579 -0.0920108591065396 Nonsignificant None 2 Molecular Function:protein kinase activity (GO:0004672),Biological Process:protein phosphorylation (GO:0006468) Janus kinase 1 2.7.10.2 ko01521 EGFR tyrosine kinase inhibitor resistance ko04151 PI3K-Akt signaling pathway ko04217 Necroptosis ko04380 Osteoclast differentiation ko04550 Signaling pathways regulating pluripotency of stem cells ko04621 NOD-like receptor signaling pathway ko04630 Jak-STAT signaling pathway ko04658 Th1 and Th2 cell differentiation ko04659 Th17 cell differentiation ko05140 Leishmaniasis ko05145 Toxoplasmosis ko05152 Tuberculosis ko05160 Hepatitis C ko05161 Hepatitis B ko05162 Measles ko05164 Influenza A ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05212 Pancreatic cancer Tyrosine kinases T Signal transduction mechanisms ; IPR001245 [Serine-threonine/tyrosine-protein kinase catalytic domain] -- -- Q80UQ2 Ras association domain-containing protein 6 Rassf6 70.7 63.9 72.8 72.1 101.2 87.8 0.794331673688242 0.112506787470243 -0.332186563499616 Nonsignificant None 1 Biological Process:signal transduction (GO:0007165) Ras association domain-containing protein 6 -- ko04390 Hippo signaling pathway ko04392 Hippo signaling pathway - multiple species Ras GTPase effector RASSF2 T Signal transduction mechanisms ; IPR000159 [Ras-associating (RA) domain] ; IPR011524[SARAH domain] -- -- Q810B1 Mitochondrial ribosomal protein L43 (Fragment) Mrpl43 526.2 573.9 401.1 475.8 497.4 481.7 1.03182349302358 0.793571675426285 0.0451961999098309 Nonsignificant None -- -- large subunit ribosomal protein L43 -- -- Mitochondrial/chloroplast ribosomal protein 36a J Translation, ribosomal structure and biogenesis ; IPR007741 [Ribosomal protein/NADH dehydrogenase domain] -- -- P80560 Receptor-type tyrosine-protein phosphatase N2 Ptprn2 234.4 219.3 200 200.9 214.2 221 1.02766860556516 0.638886727295021 0.0393751106538115 Nonsignificant None 2 Molecular Function:protein tyrosine phosphatase activity (GO:0004725),Biological Process:protein dephosphorylation (GO:0006470) receptor-type tyrosine-protein phosphatase N 3.1.3.48 ko04940 Type I diabetes mellitus Protein tyrosine phosphatase T Signal transduction mechanisms ; IPR000242 [PTP type protein phosphatase] ; IPR021613[Protein-tyrosine phosphatase receptor IA-2 ectodomain] ; IPR029403[RESP18 domain] -- -- Q8K0H5 Transcription initiation factor TFIID subunit 10 Taf10 96.2 96.8 133.8 98.7 108.2 117 1.00895338067305 0.946395961615493 0.0128595153504969 Nonsignificant None 1 Cellular Component:nucleus (GO:0005634) transcription initiation factor TFIID subunit 10 -- ko03022 Basal transcription factors ko05168 Herpes simplex infection Transcription initiation factor TFIID, subunit TAF10 (also component of histone acetyltransferase SAGA) K Transcription ; IPR003923 [Transcription initiation factor TFIID, 23-30kDa subunit] -- -- Q8BMC4 Nucleolar protein 9 Nop9 183.6 191.4 128.9 106 121.6 109 1.49702911467617 0.0510624076522831 0.582102279639804 Nonsignificant None -- -- nucleolar protein 9 -- -- Predicted RNA-binding protein, contains Pumilio domains J Translation, ribosomal structure and biogenesis ; -- -- -- B1AWI7 Guanylate cyclase Npr2 4.6 4.2 5.8 0 5 4.8 0.993197278911565 0.960824946302457 -0.00984778595634734 Nonsignificant None 5 Molecular Function:protein kinase activity (GO:0004672),Biological Process:protein phosphorylation (GO:0006468),Biological Process:cyclic nucleotide biosynthetic process (GO:0009190),Molecular Function:phosphorus-oxygen lyase activity (GO:0016849),Biological Process:intracellular signal transduction (GO:0035556) atrial natriuretic peptide receptor B 4.6.1.2 ko00230 Purine metabolism ko04022 cGMP-PKG signaling pathway ko04270 Vascular smooth muscle contraction ko04921 Oxytocin signaling pathway Natriuretic peptide receptor, guanylate cyclase T Signal transduction mechanisms ; IPR001054 [Adenylyl cyclase class-3/4/guanylyl cyclase] ; IPR001245[Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR001828[Receptor, ligand binding region] -- -- B1ART2 Vacuolar protein sorting 13D Vps13d 152 142.6 126.1 130.1 150.3 155.4 0.965351078476365 0.665867105954604 -0.0508743783471176 Nonsignificant None -- -- vacuolar protein sorting-associated protein 13D -- -- Vacuolar protein sorting-associated protein U Intracellular trafficking, secretion, and vesicular transport ; IPR009543 [Vacuolar protein sorting-associated protein 13, SHR-binding domain] ; IPR015940[Ubiquitin-associated domain] ; IPR026854[Vacuolar protein sorting-associated protein 13, N-terminal domain] ; IPR031642[VPS13, repeated coiled region] ; IPR031645[Vacuolar protein sorting-associated protein 13, C-terminal] ; IPR031646[Vacuolar protein sorting-associated protein 13, second N-terminal domain] -- -- Q8BMD6 Transmembrane protein 260 Tmem260 23.4 26 26.7 30.1 32.4 26.9 0.851230425055928 0.0782926266658629 -0.232378377679772 Nonsignificant None -- -- -- -- -- -- -- -- IPR021280 [Protein of unknown function DUF2723] -- -- Q9Z2B9 Ribosomal protein S6 kinase alpha-4 Rps6ka4 195.5 192.2 181.6 205 214.2 208.5 0.906961924486219 0.0173724775257404 -0.140886109191934 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) ribosomal protein S6 kinase alpha-4 2.7.11.1 ko04010 MAPK signaling pathway ko04668 TNF signaling pathway Ribosomal protein S6 kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR017892[Protein kinase, C-terminal] -- -- Q3UU56 Predicted gene 29609 Gm29609 285.6 277.9 250.3 279 330.3 301 0.893990991980666 0.153968867207968 -0.161667800268809 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) general transcription factor 3C polypeptide 2 -- -- -- -- -- IPR001680 [WD40 repeat] -- -- Q8BXQ4 Importin N-terminal domain-containing protein Ipo11 234.5 232.3 173.6 185 184.7 201.6 1.12095221424821 0.328403248528605 0.164724777932308 Nonsignificant None 2 Biological Process:intracellular protein transport (GO:0006886),Molecular Function:Ran GTPase binding (GO:0008536) -- -- -- Nuclear transport receptor KAP120 (importin beta superfamily) YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; IPR001494 [Importin-beta, N-terminal domain] -- -- A0A338P6I9 Uncharacterized protein Gm56451 46.6 36.9 69.5 81.2 86.7 75.3 0.629111842105263 0.0421822203873356 -0.668611575863571 Significant down -- -- -- -- -- -- -- -- -- -- -- Q810M8 Ubiquitinyl hydrolase 1 (Fragment) Atxn3 263.8 275.9 288.8 228.6 248.2 255.7 1.13105802047782 0.0418132705805903 0.177672937911842 Nonsignificant None 2 Molecular Function:thiol-dependent ubiquitin-specific protease activity (GO:0004843),Biological Process:protein deubiquitination (GO:0016579) Ataxin-3 3.4.22.- ko04141 Protein processing in endoplasmic reticulum Ataxin 3/Josephin R General function prediction only ; IPR003903 [Ubiquitin interacting motif] ; IPR006155[Josephin domain] -- -- P0C8B4 EKC/KEOPS complex subunit GON7 Gon7 146.6 138.8 127.8 148.4 162.5 154.1 0.888602150537634 0.0645344392164906 -0.170390462017696 Nonsignificant None -- -- -- -- -- -- -- -- IPR027893 [Protein of unknown function DUF4611] -- -- F6RJE8 Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (Fragment) Pip4k2a 137.7 147.4 168.1 167.3 180.7 148.6 0.912605718888441 0.325649363325102 -0.131936400356325 Nonsignificant None 2 Molecular Function:phosphatidylinositol phosphate kinase activity (GO:0016307),Biological Process:phosphatidylinositol metabolic process (GO:0046488) 1-phosphatidylinositol-5-phosphate 4-kinase 2.7.1.149 ko00562 Inositol phosphate metabolism ko04070 Phosphatidylinositol signaling system ko04810 Regulation of actin cytoskeleton Phosphatidylinositol-4-phosphate 5-kinase T Signal transduction mechanisms ; IPR002498 [Phosphatidylinositol-4-phosphate 5-kinase, core] -- -- Q3UHH8 Glucoside xylosyltransferase 1 Gxylt1 177.4 155 188.8 171 140.8 161.6 1.10097169412759 0.298564316627811 0.13877737783352 Nonsignificant None -- -- UDP-xylose:glucoside alpha-1,3-xylosyltransferase 2.4.2.- ko00514 Other types of O-glycan biosynthesis Predicted glycosyltransferase G Carbohydrate transport and metabolism ; IPR002495 [Glycosyl transferase, family 8] -- -- Q9JJV2 Profilin-2 Pfn2 420.9 410.3 464.3 570.9 553.7 510.9 0.792112503821461 0.00957840616386471 -0.336222743902684 Nonsignificant None -- -- profilin -- ko04015 Rap1 signaling pathway ko04810 Regulation of actin cytoskeleton ko05132 Salmonella infection Profilin Z Cytoskeleton ; IPR005455 [Profilin] -- -- Q7TSG2 RNA polymerase II subunit A C-terminal domain phosphatase Ctdp1 736.9 698.7 732.8 744.1 744.5 761.2 0.963819006133878 0.111992462044009 -0.0531658441469424 Nonsignificant None -- -- RNA polymerase II subunit A C-terminal domain phosphatase 3.1.3.16 -- TFIIF-interacting CTD phosphatases, including NLI-interacting factor K Transcription ; IPR004274 [FCP1 homology domain] ; IPR015388[FCP1-like phosphatase, C-terminal] -- -- B2FDF6 Synaptosomal-associated protein 47 Snap47 236.9 244.6 173.6 237.3 209.2 243.3 0.949695563931574 0.665542278798949 -0.0744629801757466 Nonsignificant None -- -- synaptosomal-associated protein 47 -- -- SNAP-25 (synaptosome-associated protein) component of SNARE complex U Intracellular trafficking, secretion, and vesicular transport ; -- -- -- Q10470 Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Mgat3 538.6 489.8 522 558.7 570.8 587 0.903233323623653 0.0284496458679667 -0.146829381429538 Nonsignificant None 3 Molecular Function:beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity (GO:0003830),Biological Process:protein N-linked glycosylation (GO:0006487),Cellular Component:membrane (GO:0016020) beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase 2.4.1.144 ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways -- -- -- IPR006813 [Glycosyl transferase, family 17] -- -- Q8C6F4 Uncharacterized protein Plek 141.6 182.3 159.6 152.6 159.2 133.7 1.08529741863075 0.417890102615238 0.118090457954919 Nonsignificant None 1 Biological Process:intracellular signal transduction (GO:0035556) pleckstrin -- -- -- -- -- IPR000591 [DEP domain] ; IPR001849[Pleckstrin homology domain] -- -- Q9CSK4 Uncharacterized protein (Fragment) Lrrc57 137.4 104.2 111.8 143.3 143.7 141.3 0.825122577632501 0.130031005357671 -0.277319637339426 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- FOG: Leucine rich repeat R General function prediction only ; IPR001611 [Leucine-rich repeat] -- -- Q60963 Platelet-activating factor acetylhydrolase Pla2g7 24.7 16.8 11 15.7 14 18.4 1.09147609147609 0.742904930181806 0.126280528783443 Nonsignificant None 2 Molecular Function:1-alkyl-2-acetylglycerophosphocholine esterase activity (GO:0003847),Biological Process:lipid catabolic process (GO:0016042) platelet-activating factor acetylhydrolase 3.1.1.47 ko00565 Ether lipid metabolism ko01100 Metabolic pathways Phospholipase A2 (platelet-activating factor acetylhydrolase in humans) I Lipid transport and metabolism ; IPR005065 [Platelet-activating factor acetylhydrolase-like] -- -- B2RXU2 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) Esf1 193 174.9 163.2 149.2 142.4 138.7 1.23425517081106 0.0217113579813845 0.303640689144515 Nonsignificant None 1 Cellular Component:nucleus (GO:0005634) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR012580 [NUC153] -- -- Q62347 Cyclic AMP-responsive element-binding protein 1 Creb1 266.6 248.7 272 303.7 297 306.4 0.867930768382758 0.00620646333578863 -0.204348126058961 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:sequence-specific DNA binding (GO:0043565) cyclic AMP-responsive element-binding protein 1 -- ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04151 PI3K-Akt signaling pathway ko04152 AMPK signaling pathway ko04211 Longevity regulating pathway ko04261 Adrenergic signaling in cardiomyocytes ko04380 Osteoclast differentiation ko04612 Antigen processing and presentation ko04668 TNF signaling pathway ko04710 Circadian rhythm ko04713 Circadian entrainment ko04725 Cholinergic synapse ko04728 Dopaminergic synapse ko04911 Insulin secretion ko04915 Estrogen signaling pathway ko04916 Melanogenesis ko04918 Thyroid hormone synthesis ko04922 Glucagon signaling pathway ko04924 Renin secretion ko04925 Aldosterone synthesis and secretion ko04926 Relaxin signaling pathway ko04931 Insulin resistance ko04962 Vasopressin-regulated water reabsorption ko05016 Huntington's disease ko05030 Cocaine addiction ko05031 Amphetamine addiction ko05034 Alcoholism ko05152 Tuberculosis ko05161 Hepatitis B ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05203 Viral carcinogenesis ko05215 Prostate cancer cAMP response element binding protein and related transcription factors K Transcription ; IPR003102 [Coactivator CBP, pKID] ; IPR004827[Basic-leucine zipper domain] -- TF_bZIP D6RGU1 Nucleolysin TIAR Tial1 401.3 390.4 377.8 341.3 338.6 337 1.15006391975612 0.00180908549201202 0.201714047389175 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) nucleolysin TIA-1/TIAR -- -- Apoptosis-promoting RNA-binding protein TIA-1/TIAR (RRM superfamily) AJ RNA processing and modification ; Translation, ribosomal structure and biogenesis ; IPR000504 [RNA recognition motif domain] -- -- Q9D8S9 BolA-like protein 1 Bola1 309.2 305.4 304.7 259.1 272.5 307.8 1.09518703836073 0.207209380480987 0.13117727738107 Nonsignificant None -- -- BolA-like protein 1 -- -- Stress-induced protein UVI31+ T Signal transduction mechanisms ; IPR002634 [BolA protein] -- -- D3YXV1 Indoleamine 2,3-dioxygenase 1 Ido1 140.9 142.8 175.3 141 142.8 130.3 1.10842791596233 0.274348252568444 0.148514950931292 Nonsignificant None 1 Molecular Function:heme binding (GO:0020037) indoleamine 2,3-dioxygenase 1.13.11.52 ko00380 Tryptophan metabolism ko01100 Metabolic pathways ko05143 African trypanosomiasis -- -- -- IPR000898 [Indoleamine 2,3-dioxygenase] -- -- D3Z0I8 Transmembrane protein 109 (Fragment) Tmem109 251.4 239.1 270.9 280.5 278.8 268.6 0.919676289406933 0.090407901220561 -0.12080194877042 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q91Z58 Uncharacterized protein C6orf132 homolog 43.3 43.5 25.6 23.4 27.2 32.6 1.35096153846154 0.208990106884318 0.433986602079834 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- P84102 Small EDRK-rich factor 2 Serf2 416.2 376.5 301.4 296.1 279.7 327.9 1.21068938807126 0.157176148338475 0.275828777692474 Nonsignificant None -- -- -- -- -- Small EDRK-rich protein H4F5 R General function prediction only ; IPR007513 [Uncharacterised protein family SERF] -- -- Q3UZW7 Protein-lysine N-methyltransferase EEF2KMT Eef2kmt 159.9 154.1 123.1 94.6 110.6 104.1 1.41319107662464 0.0259489307385084 0.498956544696404 Nonsignificant None -- -- -- -- -- Predicted methyltransferase R General function prediction only ; IPR019410 [Lysine methyltransferase] ; IPR029426[FAM86] -- -- Q9CR56 NF-kappa-B inhibitor-interacting Ras-like protein 2 Nkiras2 259.4 244.7 277 331.3 337.1 320.7 0.789707815185522 0.00272476649281621 -0.340609127110379 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) NF-kappa-B inhibitor-interacting Ras-like protein -- -- Ras family small GTPase T Signal transduction mechanisms ; IPR001806 [Small GTPase superfamily] -- -- Q3U2A8 Valine--tRNA ligase, mitochondrial Vars2 22.9 21.2 29.9 38.3 31.3 32.5 0.724779627815867 0.0523617006770147 -0.464385690361489 Nonsignificant None 4 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation for protein translation (GO:0006418) valyl-tRNA synthetase 6.1.1.9 ko00970 Aminoacyl-tRNA biosynthesis Valyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR002300 [Aminoacyl-tRNA synthetase, class Ia] ; IPR013155[Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding] -- -- D3YX43 V-set and immunoglobulin domain-containing protein 10 Vsig10 261.1 225.8 245.9 296.3 301.2 321.1 0.797735684737644 0.00824480635390732 -0.326017280124 Nonsignificant None -- -- -- -- -- -- -- -- IPR013098 [Immunoglobulin I-set] -- -- E0CXE7 CST complex subunit CTC1 Ctc1 324.7 342.4 323.9 348.8 382.2 342.8 0.92289066865338 0.113487000157125 -0.115768347486687 Nonsignificant None 1 Molecular Function:single-stranded DNA binding (GO:0003697) -- -- -- -- -- -- IPR029156 [CST complex subunit CTC1] -- -- O35566 CD151 antigen Cd151 253.1 239.2 208.5 300 291.8 299.6 0.786179044200135 0.00913134684997347 -0.347070186011481 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) CD151 antigen -- -- Tetraspanin family integral membrane protein R General function prediction only ; IPR018499 [Tetraspanin/Peripherin] -- -- F6VT60 AFG1-like ATPase (Fragment) Afg1l 128.7 130.2 147.8 185.4 214.4 184.2 0.696404109589041 0.00705526037754574 -0.522003378305247 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) peroxisome-assembly ATPase 3.6.4.7 -- Predicted ATPase R General function prediction only ; IPR005654 [ATPase, AFG1-like] -- -- Q9D787 RING-type E3 ubiquitin-protein ligase PPIL2 Ppil2 423.5 402.4 382.7 519.4 535.3 389 0.837154533490337 0.176588756098362 -0.256434135048665 Nonsignificant None 3 Biological Process:protein peptidyl-prolyl isomerization (GO:0000413),Molecular Function:peptidyl-prolyl cis-trans isomerase activity (GO:0003755),Biological Process:protein folding (GO:0006457) peptidyl-prolyl cis-trans isomerase-like 2 5.2.1.8 ko04120 Ubiquitin mediated proteolysis Cyclophilin type, U box-containing peptidyl-prolyl cis-trans isomerase O Posttranslational modification, protein turnover, chaperones ; IPR002130 [Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain] -- -- A0A0U1RP13 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Cdipt 98.6 127.5 162.1 195.8 174.1 129 0.778111846061335 0.242152706538437 -0.361950551294762 Nonsignificant None 2 Biological Process:phospholipid biosynthetic process (GO:0008654),Cellular Component:membrane (GO:0016020) CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2.7.8.11 ko00562 Inositol phosphate metabolism ko00564 Glycerophospholipid metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system Phosphatidylinositol synthase I Lipid transport and metabolism ; IPR000462 [CDP-alcohol phosphatidyltransferase] -- -- P42337 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Pik3ca 94.2 101.5 123.4 141.4 134.1 131.3 0.784414945919371 0.0344603372708159 -0.350311070578188 Nonsignificant None 1 Molecular Function:kinase activity (GO:0016301) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta 2.7.1.153 ko00562 Inositol phosphate metabolism ko01521 EGFR tyrosine kinase inhibitor resistance ko01522 Endocrine resistance ko01524 Platinum drug resistance ko04012 ErbB signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04024 cAMP signaling pathway ko04062 Chemokine signaling pathway ko04066 HIF-1 signaling pathway ko04068 FoxO signaling pathway ko04070 Phosphatidylinositol signaling system ko04071 Sphingolipid signaling pathway ko04072 Phospholipase D signaling pathway ko04140 Autophagy - animal ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04152 AMPK signaling pathway ko04210 Apoptosis ko04211 Longevity regulating pathway ko04213 Longevity regulating pathway - multiple species ko04218 Cellular senescence ko04360 Axon guidance ko04370 VEGF signaling pathway ko04380 Osteoclast differentiation ko04510 Focal adhesion ko04550 Signaling pathways regulating pluripotency of stem cells ko04611 Platelet activation ko04620 Toll-like receptor signaling pathway ko04630 Jak-STAT signaling pathway ko04650 Natural killer cell mediated cytotoxicity ko04660 T cell receptor signaling pathway ko04662 B cell receptor signaling pathway ko04664 Fc epsilon RI signaling pathway ko04666 Fc gamma R-mediated phagocytosis ko04668 TNF signaling pathway ko04670 Leukocyte transendothelial migration ko04722 Neurotrophin signaling pathway ko04725 Cholinergic synapse ko04750 Inflammatory mediator regulation of TRP channels ko04810 Regulation of actin cytoskeleton ko04910 Insulin signaling pathway ko04914 Progesterone-mediated oocyte maturation ko04915 Estrogen signaling pathway ko04917 Prolactin signaling pathway ko04919 Thyroid hormone signaling pathway ko04923 Regulation of lipolysis in adipocytes ko04926 Relaxin signaling pathway ko04930 Type II diabetes mellitus ko04931 Insulin resistance ko04932 Non-alcoholic fatty liver disease (NAFLD) ko04933 AGE-RAGE signaling pathway in diabetic complications ko04960 Aldosterone-regulated sodium reabsorption ko04973 Carbohydrate digestion and absorption ko05100 Bacterial invasion of epithelial cells ko05142 Chagas disease (American trypanosomiasis) ko05146 Amoebiasis ko05160 Hepatitis C ko05161 Hepatitis B ko05162 Measles ko05164 Influenza A ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05205 Proteoglycans in cancer ko05210 Colorectal cancer ko05211 Renal cell carcinoma ko05212 Pancreatic cancer ko05213 Endometrial cancer ko05214 Glioma ko05215 Prostate cancer ko05218 Melanoma ko05220 Chronic myeloid leukemia ko05221 Acute myeloid leukemia ko05222 Small cell lung cancer ko05223 Non-small cell lung cancer ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer ko05230 Central carbon metabolism in cancer ko05231 Choline metabolism in cancer ko05418 Fluid shear stress and atherosclerosis Phosphatidylinositol 3-kinase catalytic subunit (p110) T Signal transduction mechanisms ; IPR000341 [Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain] ; IPR000403[Phosphatidylinositol 3-/4-kinase, catalytic domain] ; IPR001263[Phosphoinositide 3-kinase, accessory (PIK) domain] ; IPR002420[Phosphatidylinositol 3-kinase, C2 domain] ; IPR003113[Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain] -- -- Q32NY4 Metal transporter CNNM3 Cnnm3 25 22.8 20.6 28.3 19.3 21.9 0.984172661870504 0.907405338583083 -0.023016652724972 Nonsignificant None -- -- metal transporter CNNM -- -- Predicted membrane protein, contains two CBS domains S Function unknown ; IPR000644 [CBS domain] -- -- Q497V5 S1 RNA-binding domain-containing protein 1 Srbd1 345.7 321 335.7 315.9 314.1 342.8 1.03042763157895 0.447614545020886 0.043243185878275 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- Transcription accessory protein TEX, contains S1 domain K Transcription ; IPR003029 [S1 domain] ; IPR018974[Tex-like protein, N-terminal] ; IPR032639[Tex protein, YqgF-like domain] -- -- A2A7S8 Uncharacterized protein KIAA1522 Kiaa1522 355.1 384.4 394.5 438 459.3 380.9 0.887185104052574 0.140687646368328 -0.172692952212235 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Z4YJE9 Queuine tRNA-ribosyltransferase accessory subunit 2 Qtrt2 278.9 255.2 189.9 205 213.3 235.4 1.10754168578859 0.451451527174261 0.147361000133505 Nonsignificant None 1 Biological Process:tRNA modification (GO:0006400) queuine tRNA-ribosyltransferase subunit QTRTD1 2.4.2.29 -- Queuine-tRNA ribosyltransferase A RNA processing and modification ; IPR002616 [tRNA-guanine(15) transglycosylase-like] -- -- G3UY13 Interleukin-1 receptor accessory protein Il1rap 227.6 257.6 220.4 205.4 264.6 240 0.993802816901408 0.946672746894987 -0.00896846372188614 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) interleukin 1 receptor accessory protein -- ko04010 MAPK signaling pathway ko04060 Cytokine-cytokine receptor interaction ko04659 Th17 cell differentiation ko04750 Inflammatory mediator regulation of TRP channels -- -- -- IPR007110 [Immunoglobulin-like domain] -- -- Q8K039 Uncharacterized protein KIAA1143 homolog 218.5 234 219.3 201.3 215.5 192.7 1.10221493027071 0.0675139578521495 0.140405574726924 Nonsignificant None -- -- -- -- -- -- -- -- IPR027911 [Domain of unknown function DUF4604] -- -- Q9CY19 Perilipin Plin2 34.4 34.7 27.2 14.7 16.6 19 1.91451292246521 0.00506542681813583 0.936977398037932 Significant up -- -- perilipin-2 -- ko03320 PPAR signaling pathway -- -- -- IPR004279 [Perilipin] -- -- Q6PB99 Ena/VASP-like protein Evl 434.5 436.7 423.1 378.6 382.7 405.1 1.1096536351166 0.00996818248555954 0.150109427134863 Nonsignificant None -- -- -- -- -- Signal transduction protein Enabled, contains WH1 domain T Signal transduction mechanisms ; IPR000697 [WH1/EVH1 domain] ; IPR014885[VASP tetramerisation] -- -- Q8BXJ6 Asparagine--tRNA ligase Nars2 212.8 227.5 214.9 253.2 248.8 224.8 0.901485965877821 0.0744174590981897 -0.149623062593107 Nonsignificant None 5 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation for protein translation (GO:0006418) asparaginyl-tRNA synthetase 6.1.1.22 ko00970 Aminoacyl-tRNA biosynthesis Asparaginyl-tRNA synthetase (mitochondrial) J Translation, ribosomal structure and biogenesis ; IPR004364 [Aminoacyl-tRNA synthetase, class II (D/K/N)] ; IPR004365[OB-fold nucleic acid binding domain, AA-tRNA synthetase-type] -- -- Q5SX75 Procollagen-proline 4-dioxygenase P4ha2 479.3 553.8 449.5 470.1 417.9 430.7 1.12428907257147 0.191186826241008 0.169013023055692 Nonsignificant None 4 Molecular Function:procollagen-proline 4-dioxygenase activity (GO:0004656),Cellular Component:endoplasmic reticulum (GO:0005783),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) prolyl 4-hydroxylase 1.14.11.2 ko00330 Arginine and proline metabolism ko01100 Metabolic pathways Prolyl 4-hydroxylase alpha subunit E Amino acid transport and metabolism ; IPR005123 [Oxoglutarate/iron-dependent dioxygenase] ; IPR013547[Prolyl 4-hydroxylase alpha-subunit, N-terminal] -- -- Q99KD6 Cox7a2l protein Cox7a2l 378.5 458.4 224.5 638.3 213.3 575 0.744006729286415 0.460131352866021 -0.426612424811803 Nonsignificant None -- -- cytochrome c oxidase subunit 7a -- ko00190 Oxidative phosphorylation ko04260 Cardiac muscle contraction ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease -- -- -- -- -- -- Q8VEA4 Mitochondrial intermembrane space import and assembly protein 40 Chchd4 273.3 274.5 421.2 452.2 428 473.1 0.716027488361782 0.0652449145418127 -0.481913121138066 Nonsignificant None -- -- mitochondrial intermembrane space import and assembly protein 40 -- -- Uncharacterized conserved protein S Function unknown ; IPR010625 [CHCH] -- -- Q059G7 Mitochondrial ribosomal protein S21 Mrps21 185.1 178.1 191 176 171.1 180.1 1.05121396054628 0.118851957376338 0.0720563404733652 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S21 -- ko03010 Ribosome -- -- -- IPR001911 [Ribosomal protein S21] -- -- Q3URI3 Phosphatidylinositol-3,4-bisphosphate 4-phosphatase (Fragment) Inpp4b 256.6 237.8 188.5 233.7 242.3 257.6 0.930888767720829 0.475303559448058 -0.103319305024596 Nonsignificant None -- -- inositol polyphosphate-4-phosphatase 3.1.3.66 ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system Inositol-polyphosphate 4-phosphatase T Signal transduction mechanisms ; -- -- -- Q4FZC9 Nesprin-3 Syne3 129.9 137.9 134.6 133.3 144.3 152.5 0.935596372936526 0.200290371538887 -0.0960418261391226 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:integral component of membrane (GO:0016021) nesprin-3 -- -- -- -- -- IPR002017 [Spectrin repeat] ; IPR012315[KASH domain] -- -- Q3U4K7 Uncharacterized protein Vav1 241.6 302.2 283 293.3 312.4 284.7 0.928571428571429 0.341688338483275 -0.106915203916512 Nonsignificant None 4 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Molecular Function:protein binding (GO:0005515),Biological Process:regulation of Rho protein signal transduction (GO:0035023),Biological Process:intracellular signal transduction (GO:0035556) guanine nucleotide exchange factor VAV -- ko04024 cAMP signaling pathway ko04062 Chemokine signaling pathway ko04510 Focal adhesion ko04650 Natural killer cell mediated cytotoxicity ko04660 T cell receptor signaling pathway ko04662 B cell receptor signaling pathway ko04664 Fc epsilon RI signaling pathway ko04666 Fc gamma R-mediated phagocytosis ko04670 Leukocyte transendothelial migration ko04810 Regulation of actin cytoskeleton Rho guanine nucleotide exchange factor VAV3 T Signal transduction mechanisms ; IPR000219 [Dbl homology (DH) domain] ; IPR000980[SH2 domain] ; IPR001452[SH3 domain] ; IPR001849[Pleckstrin homology domain] ; IPR002219[Protein kinase C-like, phorbol ester/diacylglycerol-binding domain] ; IPR022613[Calmodulin-regulated spectrin-associated protein, CH domain] -- -- Q9CQU3 Protein RER1 Rer1 298.1 289.4 433 499.1 494.6 448.7 0.707501386577926 0.0459889914551475 -0.49919511951226 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) -- -- -- Golgi proteins involved in ER retention (RER) U Intracellular trafficking, secretion, and vesicular transport ; IPR004932 [Retrieval of early ER protein Rer1] -- -- A0A668KLU7 Steroid hormone receptor ERR1 Esrra 146.1 142.6 167.3 193.4 219.5 188.2 0.758609216436533 0.0174503651051779 -0.398571195669515 Nonsignificant None 4 Cellular Component:nucleus (GO:0005634),Molecular Function:zinc ion binding (GO:0008270),Biological Process:steroid hormone mediated signaling pathway (GO:0043401),Molecular Function:sequence-specific DNA binding (GO:0043565) estrogen-related receptor alpha -- -- FOG: Hormone receptors T Signal transduction mechanisms ; IPR000536 [Nuclear hormone receptor, ligand-binding domain] ; IPR001628[Zinc finger, nuclear hormone receptor-type] -- ESR-like Q8C405 Nuclear autoantigen Sp-100 Sp100 221.7 250.8 247 245.9 269.4 256.7 0.93199481865285 0.198955805529626 -0.101606160527782 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Molecular Function:protein binding (GO:0005515),Cellular Component:nucleus (GO:0005634) nuclear autoantigen Sp-100 -- ko05168 Herpes simplex infection ko05203 Viral carcinogenesis Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR000770 [SAND domain] ; IPR001487[Bromodomain] ; IPR004865[HSR domain] -- SAND P11680 Properdin Cfp 189.7 185.1 192.3 219.4 207 156.3 0.973228076197014 0.813411565310426 -0.0391501543829759 Nonsignificant None -- -- complement factor properdin -- ko05168 Herpes simplex infection FOG: Immunoglobin and related proteins RP General function prediction only ; Inorganic ion transport and metabolism ; IPR000884 [Thrombospondin type-1 (TSP1) repeat] -- -- Q3UJN6 Double-strand break repair protein Mre11a 233.8 219.8 233.8 230 246.9 232.8 0.968578272509511 0.348686869094264 -0.046059454630419 Nonsignificant None 5 Molecular Function:endonuclease activity (GO:0004519),Cellular Component:nucleus (GO:0005634),Biological Process:double-strand break repair (GO:0006302),Molecular Function:hydrolase activity (GO:0016787),Molecular Function:manganese ion binding (GO:0030145) double-strand break repair protein MRE11 -- ko03440 Homologous recombination ko03450 Non-homologous end-joining ko04218 Cellular senescence DNA repair exonuclease MRE11 L Replication, recombination and repair ; IPR004843 [Calcineurin-like phosphoesterase domain, ApaH type] ; IPR007281[Mre11, DNA-binding] -- -- Q9CRC3 UPF0235 protein C15orf40 homolog 274.5 275.2 293.2 281.7 285 275.3 1.00106888361045 0.966680275493167 0.00154124952257114 Nonsignificant None -- -- uncharacterized protein -- -- Uncharacterized conserved protein, contains YggU domain S Function unknown ; IPR003746 [Protein of unknown function DUF167] -- -- Q5SRW8 Vacuolar protein sorting-associated protein 54 (Fragment) Vps54 56.7 58.8 62.6 76.9 69.4 63.8 0.847691575440267 0.0627413227089117 -0.238388645571427 Nonsignificant None -- -- vacuolar protein sorting-associated protein 54 -- -- Vacuolar sorting protein VPS45 U Intracellular trafficking, secretion, and vesicular transport ; IPR012501 [Vps54-likeVacuolar protein sorting-associated protein 54, C-terminal] ; IPR019515[Vacuolar protein sorting-associated protein 54, N-terminal] -- -- Q8BTW7 alpha-1,2-Mannosidase (Fragment) Man1b1 117 107.8 110.7 125.2 147.9 131.1 0.830034636318654 0.0352720103373614 -0.26875655529219 Nonsignificant None 3 Molecular Function:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity (GO:0004571),Molecular Function:calcium ion binding (GO:0005509),Cellular Component:membrane (GO:0016020) mannosyl-oligosaccharide alpha-1,2-mannosidase 3.2.1.113 ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways ko04141 Protein processing in endoplasmic reticulum 1, 2-alpha-mannosidase G Carbohydrate transport and metabolism ; IPR001382 [Glycoside hydrolase family 47] -- -- Q99NF1 Carotenoid-cleaving dioxygenase, mitochondrial Bco2 67.4 58.6 68.1 58.8 58.7 65.5 1.06065573770492 0.384852326152247 0.0849564695422591 Nonsignificant None 1 Biological Process:oxidation-reduction process (GO:0055114) beta,beta-carotene 9',10'-dioxygenase 1.13.11.71 -- Beta, beta-carotene 15,15'-dioxygenase and related enzymes Q Secondary metabolites biosynthesis, transport and catabolism ; IPR004294 [Carotenoid oxygenase] -- -- Q7TSH6 SR-related and CTD-associated factor 4 Scaf4 87.9 85.9 129.1 143.3 148.3 123.9 0.729001203369434 0.0779166399386851 -0.456006898862334 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) splicing factor, arginine/serine-rich 15 -- -- RNA polymerase II C-terminal domain-binding protein RA4, contains RPR and RRM domains AK RNA processing and modification ; Transcription ; IPR000504 [RNA recognition motif domain] ; IPR006903[RNA polymerase II-binding domain] -- -- Q3TBP4 N-terminal amino-acid N(alpha)-acetyltransferase NatA 148.6 130.8 124.2 124.8 127.5 139.1 1.03117015840572 0.657510784371452 0.0442824184795535 Nonsignificant None 1 Molecular Function:N-acetyltransferase activity (GO:0008080) N-alpha-acetyltransferase 10/11 2.3.1.255 -- Subunit of the major N alpha-acetyltransferase R General function prediction only ; IPR000182 [GNAT domain] -- -- Q8CCA5 Apolipoprotein L 10A Apol10a 76.8 58.7 118.1 50.3 43.6 49.2 1.77218728162124 0.169449576306918 0.825531073412739 Nonsignificant None 4 Cellular Component:extracellular region (GO:0005576),Biological Process:lipid transport (GO:0006869),Molecular Function:lipid binding (GO:0008289),Biological Process:lipoprotein metabolic process (GO:0042157) apolipoprotein L -- -- -- -- -- IPR008405 [Apolipoprotein L] -- -- A4FUU4 Retsat protein (Fragment) Retsat 307 318.3 314 290.2 299.4 304.6 1.05043614403936 0.0481864049220769 0.0709884633171844 Nonsignificant None -- -- all-trans-retinol 13,14-reductase 1.3.99.23 ko00830 Retinol metabolism Phytoene desaturase H Coenzyme transport and metabolism ; -- -- -- Q8R344 Coiled-coil domain-containing protein 12 Ccdc12 570.8 616.9 480.5 420.5 416.4 401.4 1.3471695065816 0.0671814477201457 0.429931388230881 Nonsignificant None -- -- coiled-coil domain-containing protein 12 -- ko03040 Spliceosome Uncharacterized conserved protein S Function unknown ; IPR013169 [mRNA splicing factor, Cwf18] -- -- A0A498WGR4 Galanin peptides Gal 188.7 172.6 205.5 181.1 214.2 210.3 0.935931307793923 0.411429270456121 -0.0955254470677131 Nonsignificant None 2 Molecular Function:hormone activity (GO:0005179),Cellular Component:extracellular region (GO:0005576) galanin -- -- -- -- -- IPR008174 [Galanin] ; IPR013068[Galanin message associated peptide (GMAP)] -- -- Q99JR9 Cilia- and flagella-associated protein 36 Cfap36 55.7 57.2 63.7 58.6 44 52.8 1.13642213642214 0.22295922182187 0.184498839240756 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR023379 [ADP-ribosylation factor-like 2-binding protein, domain] -- -- E9Q3B1 RCC1 and BTB domain-containing protein 2 Rcbtb2 44.7 38.7 39 44 41.4 48.1 0.91685393258427 0.251018507193187 -0.125236183882264 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) RCC1 and BTB domain-containing protein -- -- FOG: RCC1 domain S Function unknown ; IPR000210 [BTB/POZ domain] ; IPR000408[Regulator of chromosome condensation, RCC1] -- ZBTB Q8BY82 Uncharacterized protein Eif4enif1 264.2 262.8 260.2 218.6 231.1 216.4 1.18180453385378 0.00103058528747371 0.240991438764806 Nonsignificant None -- -- eukaryotic translation initiation factor 4E transporter -- -- -- -- -- IPR018862 [Eukaryotic translation initiation factor 4E binding protein] -- -- Q6DID7 Protein wntless homolog Wls 265.8 261.5 291.8 308.7 302.5 281.2 0.917861945316002 0.124657582497276 -0.123650919228414 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q9CQL7 MORF4 family-associated protein 1 Mrfap1 338.2 374.9 294.8 230.8 215.1 236.8 1.47634392851912 0.0107421322973548 0.562028850239125 Nonsignificant None -- -- -- -- -- -- -- -- IPR029254 [MORF4 family-associated protein 1] -- -- P13405 Retinoblastoma-associated protein Rb1 148.3 160.5 144.2 161.4 143.5 156 0.982859622477761 0.733624907983536 -0.0249427174030514 Nonsignificant None 2 Cellular Component:nucleus (GO:0005634),Biological Process:regulation of cell cycle (GO:0051726) retinoblastoma-associated protein -- ko01522 Endocrine resistance ko04110 Cell cycle ko04218 Cellular senescence ko05161 Hepatitis B ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05212 Pancreatic cancer ko05214 Glioma ko05215 Prostate cancer ko05218 Melanoma ko05219 Bladder cancer ko05220 Chronic myeloid leukemia ko05222 Small cell lung cancer ko05223 Non-small cell lung cancer ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer Rb (Retinoblastoma tumor suppressor)-related protein D Cell cycle control, cell division, chromosome partitioning ; IPR002719 [Retinoblastoma-associated protein, B-box] ; IPR002720[Retinoblastoma-associated protein, A-box] ; IPR015030[Retinoblastoma-associated protein, C-terminal] ; IPR024599[Retinoblastoma-associated protein, N-terminal] -- -- Q6PCP5 Mitochondrial fission factor Mff 39.2 43.1 35.2 32.4 48 33.6 1.03070175438597 0.842564534288996 0.0436269324002583 Nonsignificant None -- -- mitochondrial fission factor -- -- -- -- -- -- -- -- Q9DCL2 Cytosolic iron-sulfur assembly component 2A Ciao2a 235.4 238.2 244 246.5 276.2 268 0.907550271910965 0.0572494441989592 -0.139950534392898 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR002744 [Domain of unknown function DUF59] -- -- B2RXC2 Kinase Itpkb 125.2 112.2 102.8 135.5 130.1 152.1 0.814460138855638 0.049522820110569 -0.296084002499407 Nonsignificant None 1 Molecular Function:inositol-1,4,5-trisphosphate 3-kinase activity (GO:0008440) 1D-myo-inositol-triphosphate 3-kinase 2.7.1.127 ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04020 Calcium signaling pathway ko04070 Phosphatidylinositol signaling system 1D-myo-inositol-triphosphate 3-kinase A I Lipid transport and metabolism ; IPR005522 [Inositol polyphosphate kinase] -- -- B1B1D8 39S ribosomal protein L2, mitochondrial Mrpl2 646.1 629.5 367.6 386.7 397.6 428.8 1.35454620394032 0.251507988809036 0.437809605100421 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L2 -- ko03010 Ribosome Mitochondrial/chloroplast ribosomal protein L2 J Translation, ribosomal structure and biogenesis ; IPR022666 [Ribosomal Proteins L2, RNA binding domain] ; IPR022669[Ribosomal protein L2, C-terminal] -- -- P26339 Chromogranin-A Chga 540 512.9 441.8 519.4 578.3 456.6 0.961654764202535 0.686437919005768 -0.0564090380711027 Nonsignificant None 1 Cellular Component:secretory granule (GO:0030141) chromogranin-A -- -- -- -- -- IPR001990 [Chromogranin A/B/C] -- -- Q8CFI5 Probable proline--tRNA ligase, mitochondrial Pars2 315.2 301 260.2 278.2 293.1 306.6 0.998291377150017 0.979636091137344 -0.0024671300104982 Nonsignificant None 4 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation for protein translation (GO:0006418) prolyl-tRNA synthetase 6.1.1.15 ko00970 Aminoacyl-tRNA biosynthesis Prolyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR002314 [Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)] ; IPR004154[Anticodon-binding] -- -- B0QZT2 Dehydrogenase/reductase SDR family member 13 Dhrs13 181.7 183.5 162.1 159.2 186.6 164 1.03432718713221 0.620215320660715 0.0486926233576305 Nonsignificant None -- -- dehydrogenase/reductase SDR family member 13 1.1.-.- -- Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Q Secondary metabolites biosynthesis, transport and catabolism ; -- -- -- Q80U38 Protein KHNYN Khnyn 72.5 69.1 65.9 75.3 73.6 66.5 0.963324048282266 0.469657910563954 -0.0539069134225579 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR021869 [Ribonuclease Zc3h12a-like, NYN domain] -- -- Q8R395 COMM domain-containing protein 5 Commd5 289.2 281.9 277.8 287.4 314.5 303.3 0.937803800265135 0.0929068761594635 -0.0926419695793697 Nonsignificant None -- -- -- -- -- IPR017920 [COMM domain] -- -- E9PW03 Glycosylphosphatidylinositol anchor attachment 1 protein Gpaa1 338.8 321.6 398.9 473.6 438.3 461 0.771578410663559 0.0150717283244188 -0.374115318613321 Nonsignificant None 2 Cellular Component:integral component of membrane (GO:0016021),Cellular Component:GPI-anchor transamidase complex (GO:0042765) glycosylphosphatidylinositol transamidase -- ko00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis ko01100 Metabolic pathways Glycosylphosphatidylinositol anchor attachment protein GAA1 O Posttranslational modification, protein turnover, chaperones ; IPR007246 [GPI transamidase component Gaa1] -- -- Q9D8Z2 TP53-regulated inhibitor of apoptosis 1 Triap1 443 437.2 512.4 405.4 416.4 465 1.08221945912341 0.309334851212012 0.1139930874129 Nonsignificant None -- -- TRIAP1/MDM35 family protein -- -- Uncharacterized conserved protein S Function unknown ; IPR007918 [Mitochondrial distribution/morphology family 35/apoptosis] -- -- Q9JLB9 Nectin-3 Nectin3 15.5 11.1 17.6 17.7 14.9 19.7 0.845124282982792 0.317768035556591 -0.24276457685551 Nonsignificant None -- -- poliovirus receptor-related protein 3 -- ko04514 Cell adhesion molecules (CAMs) ko04520 Adherens junction -- -- -- IPR013106 [Immunoglobulin V-set domain] ; IPR013162[CD80-like, immunoglobulin C2-set] -- -- Q9CQQ8 U6 snRNA-associated Sm-like protein LSm7 Lsm7 173.4 164.8 203.6 189.9 194.1 198.4 0.930288461538462 0.323119478608759 -0.104249961996682 Nonsignificant None -- -- U6 snRNA-associated Sm-like protein LSm7 -- ko03018 RNA degradation ko03040 Spliceosome Small Nuclear ribonucleoprotein splicing factor A RNA processing and modification ; IPR001163 [LSM domain, eukaryotic/archaea-type] -- -- Q8VEJ4 Notchless protein homolog 1 Nle1 127.6 128.1 142.6 144.7 163 134.7 0.900316455696202 0.201814141845947 -0.151495905870521 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) ribosome assembly protein 4 -- -- Notchless-like WD40 repeat-containing protein S Function unknown ; IPR001680 [WD40 repeat] ; IPR012972[NLE] -- -- Q8CDJ8 Stonin-1 Ston1 389.7 441.8 394.5 428.8 461.7 445.2 0.917870779366624 0.128765325623015 -0.123637033937977 Nonsignificant None -- -- stonin-1/2 -- -- Stoned B synaptic vesicle biogenesis protein U Intracellular trafficking, secretion, and vesicular transport ; IPR028565 [Mu homology domain] -- -- Q9D394 Protein RUFY3 Rufy3 186.3 180.6 200.8 175.2 184.9 186.2 1.03917261577888 0.362259039276032 0.0554353185768827 Nonsignificant None -- -- -- -- -- RUN domain-containing protein T Signal transduction mechanisms ; IPR004012 [RUN domain] -- -- Q9WUR0 Tubulo-interstitial nephritis antigen Tinag 340.2 326.9 305.3 416 379.2 434.9 0.790504837005122 0.0111553598662269 -0.339153804597262 Nonsignificant None 5 Molecular Function:scavenger receptor activity (GO:0005044),Biological Process:proteolysis (GO:0006508),Biological Process:immune response (GO:0006955),Molecular Function:cysteine-type peptidase activity (GO:0008234),Molecular Function:polysaccharide binding (GO:0030247) -- -- -- Predicted cysteine proteinase TIN-ag R General function prediction only ; IPR000668 [Peptidase C1A, papain C-terminal] ; IPR001212[Somatomedin B domain] -- -- Q99LT0 Protein dpy-30 homolog Dpy30 884.3 892 820.7 730.3 766 758.4 1.15181620614716 0.0104024448227081 0.203910526125351 Nonsignificant None -- -- protein dpy-30 -- -- Histone H3 (Lys4) methyltransferase complex, subunit CPS25/DPY-30 K Transcription ; IPR007858 [Dpy-30 motif] -- -- Q03517 Secretogranin-2 Scg2 100 89.1 130 132.9 155.1 129.2 0.764860977948226 0.0895690092729053 -0.386730549240454 Nonsignificant None 1 Cellular Component:secretory granule (GO:0030141) -- -- -- -- -- -- IPR001990 [Chromogranin A/B/C] -- -- Q9D945 Protein LLP homolog Llph 326.4 303.8 307.2 305.3 306.9 314.5 1.0115463472537 0.662736425197011 0.0165624231302303 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR018784 [Learning associated protein 18-like] -- -- A2AD97 Matrix remodeling-associated protein 8 (Fragment) Mxra8 67.8 87.3 78.6 116 92 88.6 0.787929871881322 0.111586732801935 -0.343860863671805 Nonsignificant None -- -- -- -- -- -- -- -- IPR013106 [Immunoglobulin V-set domain] -- -- Q8CHW5 BICD family-like cargo adapter 2 Bicdl2 156.1 134.1 101.9 94.4 111.7 104.1 1.26402321083172 0.173672808351922 0.338022955480498 Nonsignificant None -- -- coiled-coil domain-containing protein 64 -- -- -- -- -- -- -- -- Q31096 H2-Mb1 beta chain (Fragment) H2-DMa 21.5 19 24.5 24 21.7 25.3 0.915492957746479 0.353406383412803 -0.127379306476228 Nonsignificant None 4 Biological Process:immune response (GO:0006955),Cellular Component:membrane (GO:0016020),Biological Process:antigen processing and presentation (GO:0019882),Cellular Component:MHC class II protein complex (GO:0042613) major histocompatibility complex, class II -- ko04145 Phagosome ko04514 Cell adhesion molecules (CAMs) ko04612 Antigen processing and presentation ko04640 Hematopoietic cell lineage ko04658 Th1 and Th2 cell differentiation ko04659 Th17 cell differentiation ko04672 Intestinal immune network for IgA production ko04940 Type I diabetes mellitus ko05140 Leishmaniasis ko05145 Toxoplasmosis ko05150 Staphylococcus aureus infection ko05152 Tuberculosis ko05164 Influenza A ko05166 HTLV-I infection ko05168 Herpes simplex infection ko05310 Asthma ko05320 Autoimmune thyroid disease ko05321 Inflammatory bowel disease (IBD) ko05322 Systemic lupus erythematosus ko05323 Rheumatoid arthritis ko05330 Allograft rejection ko05332 Graft-versus-host disease ko05416 Viral myocarditis -- -- -- IPR001003 [MHC class II, alpha chain, N-terminal] ; IPR003597[Immunoglobulin C1-set] -- -- Q99J08 SEC14-like protein 2 Sec14l2 29.5 31.3 35.2 35.4 38.6 35.7 0.875113947128532 0.0810447161583196 -0.192457214794674 Nonsignificant None -- -- -- -- -- Phosphatidylinositol transfer protein SEC14 and related proteins I Lipid transport and metabolism ; IPR001251 [CRAL-TRIO lipid binding domain] -- -- Q6PCN7 Helicase-like transcription factor Hltf 36.7 29.6 28.3 25 28.5 29 1.14666666666667 0.236376412824182 0.197446064206217 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524),Molecular Function:zinc ion binding (GO:0008270) -- -- -- Helicase-like transcription factor HLTF/DNA helicase RAD5, DEAD-box superfamily KL Transcription ; Replication, recombination and repair ; IPR000330 [SNF2-related, N-terminal domain] ; IPR001650[Helicase, C-terminal] ; IPR014905[HIRAN domain] -- -- Q9EPR5 VPS10 domain-containing receptor SorCS2 Sorcs2 569.6 496.3 481.4 376.1 403.3 413.9 1.29665633118244 0.0161141273966712 0.374796154995757 Nonsignificant None -- -- -- -- -- Sortilin and related receptors R General function prediction only ; IPR000601 [PKD domain] ; IPR031777[Sortilin, C-terminal] ; IPR031778[Sortilin, N-terminal] -- -- A2AQK4 Histamine N-methyltransferase Hnmt 70.6 71.4 65.9 85.3 70.8 86.2 0.858027238959967 0.0954846678429162 -0.220904646592977 Nonsignificant None -- -- histamine N-methyltransferase 2.1.1.8 ko00340 Histidine metabolism -- -- -- -- -- -- Q7TSJ7 Stress-activated protein kinase JNK Mapk8 27.8 28.7 31 19.9 31.8 30.7 1.0618932038835 0.686472349181983 0.0866386795364728 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) c-Jun N-terminal kinase 2.7.11.24 ko01522 Endocrine resistance ko04010 MAPK signaling pathway ko04012 ErbB signaling pathway ko04014 Ras signaling pathway ko04024 cAMP signaling pathway ko04068 FoxO signaling pathway ko04071 Sphingolipid signaling pathway ko04137 Mitophagy - animal ko04140 Autophagy - animal ko04141 Protein processing in endoplasmic reticulum ko04210 Apoptosis ko04215 Apoptosis - multiple species ko04217 Necroptosis ko04310 Wnt signaling pathway ko04380 Osteoclast differentiation ko04510 Focal adhesion ko04530 Tight junction ko04620 Toll-like receptor signaling pathway ko04621 NOD-like receptor signaling pathway ko04622 RIG-I-like receptor signaling pathway ko04657 IL-17 signaling pathway ko04658 Th1 and Th2 cell differentiation ko04659 Th17 cell differentiation ko04664 Fc epsilon RI signaling pathway ko04668 TNF signaling pathway ko04722 Neurotrophin signaling pathway ko04723 Retrograde endocannabinoid signaling ko04728 Dopaminergic synapse ko04750 Inflammatory mediator regulation of TRP channels ko04910 Insulin signaling pathway ko04912 GnRH signaling pathway ko04914 Progesterone-mediated oocyte maturation ko04917 Prolactin signaling pathway ko04920 Adipocytokine signaling pathway ko04926 Relaxin signaling pathway ko04930 Type II diabetes mellitus ko04931 Insulin resistance ko04932 Non-alcoholic fatty liver disease (NAFLD) ko04933 AGE-RAGE signaling pathway in diabetic complications ko05132 Salmonella infection ko05133 Pertussis ko05142 Chagas disease (American trypanosomiasis) ko05145 Toxoplasmosis ko05152 Tuberculosis ko05160 Hepatitis C ko05161 Hepatitis B ko05164 Influenza A ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05210 Colorectal cancer ko05212 Pancreatic cancer ko05231 Choline metabolism in cancer ko05418 Fluid shear stress and atherosclerosis Jun-N-terminal kinase (JNK) T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- E9PUE8 ATP-binding cassette sub-family C member 9 Abcc9 158.6 138.9 175.8 149.8 151.8 163.9 1.01675617615467 0.832706439173102 0.0239737542922075 Nonsignificant None 5 Molecular Function:ATP binding (GO:0005524),Biological Process:transport (GO:0006810),Cellular Component:integral component of membrane (GO:0016021),Molecular Function:ATPase activity (GO:0016887),Biological Process:transmembrane transport (GO:0055085) ATP-binding cassette subfamily C (CFTR/MRP) member 9 -- ko02010 ABC transporters Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Q Secondary metabolites biosynthesis, transport and catabolism ; IPR003439 [ABC transporter-like] ; IPR011527[ABC transporter type 1, transmembrane domain] -- -- Q9CQA1 Trafficking protein particle complex subunit 5 Trappc5 441 425.8 425 484 499.6 485.2 0.879493464052288 0.00122484062484682 -0.185255238525418 Nonsignificant None -- -- trafficking protein particle complex subunit 5 -- -- Transport protein particle (TRAPP) complex subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR007194 [Transport protein particle (TRAPP) component] -- -- A0A0R4J1J1 Probable hydrolase PNKD Pnkd 153.7 150.2 191.8 216.4 223 205.6 0.768527131782946 0.0250927649468877 -0.379831901727652 Nonsignificant None -- -- -- -- -- -- -- -- IPR031833 [Protein of unknown function DUF4748] -- -- Q8VCB1 Nucleoporin NDC1 Ndc1 196.3 198.6 197.8 176.3 163 172.3 1.15852228303362 0.00249276907797949 0.212285793285975 Nonsignificant None -- -- nucleoporin NDC1 -- ko03013 RNA transport Uncharacterized conserved protein S Function unknown ; IPR019049 [Nucleoporin protein Ndc1-Nup] -- -- Q9DB90 Nonsense-mediated mRNA decay factor SMG9 Smg9 96.7 97.3 86.5 92.4 93.5 82.8 1.04391514700409 0.465541010577305 0.0620044494829893 Nonsignificant None -- -- protein SMG9 -- -- Uncharacterized conserved protein S Function unknown ; IPR019354 [Smg8/Smg9] -- -- B7ZN28 Papilin Papln 10.8 10.3 9.9 13.2 12.3 11 0.849315068493151 0.0564771294319193 -0.235628248493142 Nonsignificant None 4 Molecular Function:metalloendopeptidase activity (GO:0004222),Molecular Function:serine-type endopeptidase inhibitor activity (GO:0004867),Molecular Function:peptidase activity (GO:0008233),Cellular Component:extracellular matrix (GO:0031012) -- -- -- FOG: Immunoglobulin C-2 Type/fibronectin type III domains T Signal transduction mechanisms ; IPR000884 [Thrombospondin type-1 (TSP1) repeat] ; IPR002223[Pancreatic trypsin inhibitor Kunitz domain] ; IPR010294[ADAM-TS Spacer 1] ; IPR010909[PLAC] ; IPR013098[Immunoglobulin I-set] ; IPR013151[Immunoglobulin] -- -- Q9D8C2 Tetraspanin-13 Tspan13 210.4 188.9 254.1 298.6 262.6 246.9 0.808563296621705 0.103481253018589 -0.306567378519482 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) tetraspanin-13/31 -- -- Tetraspanin family integral membrane protein R General function prediction only ; IPR018499 [Tetraspanin/Peripherin] -- -- Q80U70 Polycomb protein Suz12 Suz12 115.2 113.8 152.2 151.2 145.9 136.4 0.879354094579008 0.260052291717059 -0.185483874199255 Nonsignificant None -- -- polycomb protein SUZ12 -- -- Zn-finger protein joined to JAZF1 (predicted suppressor) R General function prediction only ; IPR019135 [Polycomb protein, VEFS-Box] -- -- Q99KI3 ER membrane protein complex subunit 3 Emc3 171.7 397.3 317.9 312.8 315.2 242.2 1.01919099057688 0.940667710600877 0.027424429657884 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR002809 [Integral membrane protein EMC3/TMCO1-like] -- -- Q9CZH3 Proteasome assembly chaperone 3 Psmg3 129.1 138.4 101.1 87.1 93.1 112.8 1.2580204778157 0.138276595240928 0.331155406321103 Nonsignificant None -- -- proteasome assembly chaperone 3 -- -- Uncharacterized conserved protein S Function unknown ; IPR018788 [Proteasome assembly chaperone 3] -- -- A0A0R4J288 Decapping nuclease Dxo 225.7 232.8 201.1 206.8 189.7 205.5 1.09568106312292 0.157748234559449 0.131827911790403 Nonsignificant None -- -- RAT1-interacting protein -- -- Nuclear 5'-3' exoribonuclease-interacting protein, Rai1p L Replication, recombination and repair ; IPR013961 [RAI1-like] -- -- Q8CII5 Cytotoxic granule-associated RNA-binding protein TIA1 Tia1 117.3 100.5 128.3 99.1 123.8 102.8 1.06263432606693 0.575146185921253 0.0876452217695444 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) nucleolysin TIA-1/TIAR -- -- Apoptosis-promoting RNA-binding protein TIA-1/TIAR (RRM superfamily) AJ RNA processing and modification ; Translation, ribosomal structure and biogenesis ; IPR000504 [RNA recognition motif domain] -- -- Q8K0P3 MTOR-associated protein MEAK7 Meak7 104.8 104.5 124.7 141 137.1 149.8 0.780556204720729 0.015068051486192 -0.357425576262075 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein, contains TLDc domain S Function unknown ; IPR006571 [TLDc domain] -- -- G3UWZ0 Bromodomain adjacent to zinc finger domain protein 1A Baz1a 229.3 244.8 215.1 219.2 199.3 216.7 1.08501259445844 0.165246794572435 0.11771178908199 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) bromodomain adjacent to zinc finger domain protein 1A -- -- Chromatin remodeling complex WSTF-ISWI, large subunit (contains heterochromatin localization, PHD and BROMO domains) B Chromatin structure and dynamics ; IPR001487 [Bromodomain] ; IPR013136[WSTF/Acf1/Cbp146] ; IPR018501[DDT domain] ; IPR019787[Zinc finger, PHD-finger] ; IPR028941[WHIM2 domain] ; IPR028942[WHIM1 domain] -- -- P97431 Interferon regulatory factor 6 Irf6 214.7 194.3 314 362.5 394.5 349.3 0.653529783964567 0.0314226160947077 -0.613675107988574 Significant down 1 Molecular Function:regulatory region DNA binding (GO:0000975) interferon regulatory factor 6 -- -- -- -- -- IPR001346 [Interferon regulatory factor DNA-binding domain] ; IPR019471[Interferon regulatory factor-3] -- IRF Q4FZG2 Fdx1 protein (Fragment) Fdx1 282.1 299.3 315.1 399.1 385.5 404.8 0.753741382209517 0.00092686006200691 -0.407858492620467 Nonsignificant None 2 Molecular Function:electron carrier activity (GO:0009055),Molecular Function:iron-sulfur cluster binding (GO:0051536) ferredoxin-1, mitochondrial -- -- Ferredoxin C Energy production and conversion ; IPR001041 [2Fe-2S ferredoxin-type iron-sulfur binding domain] -- -- Q8VE19 GATOR complex protein MIOS Mios 42.3 45.6 51.9 54.8 49.3 49.3 0.911342894393742 0.248610448436747 -0.133934122127497 Nonsignificant None -- -- WD repeat-containing protein mio -- ko04150 mTOR signaling pathway Uncharacterized conserved protein, contains WD40 repeats S Function unknown ; IPR031488 [WD repeat protein mio, zinc-ribbon like domain] -- -- H3BJD4 Disks large-associated protein 4 (Fragment) Dlgap4 225.9 212.4 195.6 307.1 318.7 326.7 0.665511811023622 0.000527769883472051 -0.58746382461195 Significant down 1 Biological Process:signaling (GO:0023052) -- -- -- SAP-90/PSD-95 associated protein-related protein (Vulcan) T Signal transduction mechanisms ; IPR005026 [SAPAP family] -- -- Q91WG4 Elongator complex protein 2 Elp2 399.6 447.8 457.5 444.9 431.5 414.2 1.01108011777468 0.823227256163602 0.0158973206203626 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) elongator complex protein 2 -- -- RNA polymerase II elongator complex, subunit ELP2, WD repeat superfamily BK Chromatin structure and dynamics ; Transcription ; IPR001680 [WD40 repeat] -- -- Q3UQM9 Cob_adeno_trans domain-containing protein Mmab 46.7 46.1 40.4 52.7 61.8 59.7 0.764638346727899 0.0159560642363866 -0.387150541527603 Nonsignificant None -- -- cob(I)alamin adenosyltransferase 2.5.1.17 ko00860 Porphyrin and chlorophyll metabolism ko01100 Metabolic pathways -- -- -- IPR016030 [Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase-like] -- -- A0A3Q4EGQ6 Protein SSXT Ss18 650.8 767.2 693.8 620.1 598.6 543.7 1.19825238311394 0.04648240094598 0.26093180922726 Nonsignificant None 1 Molecular Function:transcription coactivator activity (GO:0003713) protein SSXT -- ko05202 Transcriptional misregulation in cancer Calcium-responsive transcription coactivator K Transcription ; IPR007726 [SS18 family] -- -- Q3U6W5 Myeloid differentiation primary response protein MyD88 Myd88 418.7 450.2 403.3 328.7 354.9 348.4 1.2327519379845 0.00729085024440669 0.301882520872635 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Biological Process:signal transduction (GO:0007165) myeloid differentiation primary response protein MyD88 -- ko04010 MAPK signaling pathway ko04064 NF-kappa B signaling pathway ko04620 Toll-like receptor signaling pathway ko04621 NOD-like receptor signaling pathway ko05132 Salmonella infection ko05133 Pertussis ko05134 Legionellosis ko05140 Leishmaniasis ko05142 Chagas disease (American trypanosomiasis) ko05143 African trypanosomiasis ko05144 Malaria ko05145 Toxoplasmosis ko05152 Tuberculosis ko05161 Hepatitis B ko05162 Measles ko05164 Influenza A ko05168 Herpes simplex infection -- -- -- IPR000157 [Toll/interleukin-1 receptor homology (TIR) domain] ; IPR000488[Death domain] -- -- Q9D1H6 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 Ndufaf4 237.1 217.6 253 245.7 256.1 245.6 0.946882526090447 0.288178089945195 -0.0787426444201256 Nonsignificant None 1 Biological Process:mitochondrial respiratory chain complex I assembly (GO:0032981) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR009622 [NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4] -- -- Q8R480 Nuclear pore complex protein Nup85 Nup85 559.6 632.5 694 636.4 613.5 608.1 1.01512378902045 0.82550524210586 0.0216556672295994 Nonsignificant None -- -- nuclear pore complex protein Nup85 -- ko03013 RNA transport Nuclear pore complex component (sc Nup85) YU Nuclear structure ; Intracellular trafficking, secretion, and vesicular transport ; IPR011502 [Nucleoporin Nup85-like] -- -- Q9CX97 WD repeat-containing protein 55 Wdr55 14.9 15.3 11.5 18.9 17.3 14.3 0.825742574257426 0.180151827557815 -0.276236004194493 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- WD40 repeat protein R General function prediction only ; IPR001680 [WD40 repeat] ; IPR024977[Anaphase-promoting complex subunit 4, WD40 domain] -- -- Q6J9G1 Tyrosine-protein kinase STYK1 Styk1 33.8 36.4 37.9 40.7 49.3 48.7 0.779379956741168 0.027842977995731 -0.359601264588953 Nonsignificant None 2 Molecular Function:protein kinase activity (GO:0004672),Biological Process:protein phosphorylation (GO:0006468) tyrosine-protein kinase STYK1 2.7.10.2 -- Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases T Signal transduction mechanisms ; IPR001245 [Serine-threonine/tyrosine-protein kinase catalytic domain] -- -- Q76N33 AMSH-like protease Stambpl1 117.2 107.7 47.3 56 51.5 64.7 1.58072009291521 0.208118402776595 0.660581924107151 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) AMSH-like protease 3.4.19.12 -- SMAD6 interacting protein AMSH, contains JAB/MPN/Mov34 domain T Signal transduction mechanisms ; IPR000555 [JAB1/MPN/MOV34 metalloenzyme domain] ; IPR015063[USP8 dimerisation domain] -- -- E9Q2E4 HECT domain E3 ubiquitin protein ligase 4 Hectd4 42.6 39.1 48.1 47.4 46.9 49 0.905792044661549 0.170270942368958 -0.142748226263007 Nonsignificant None 1 Molecular Function:ubiquitin-protein transferase activity (GO:0004842) E3 ubiquitin-protein ligase HECTD4 2.3.2.26 -- -- -- -- IPR000569 [HECT domain] -- -- Q6NVF4 DNA helicase B Helb 288.3 275.4 312.9 276.2 302.7 314.6 0.981085618354785 0.739523038833103 -0.0275490504041983 Nonsignificant None -- -- DNA helicase B 3.6.4.12 -- -- -- -- IPR027785 [UvrD-like helicase C-terminal domain] -- -- Z4YK11 SH3 domain-containing protein 21 Sh3d21 76.7 66.9 65.7 72.9 106.7 83.1 0.796726303768557 0.168358004330626 -0.327843888877923 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Adaptor protein CMS/SETA T Signal transduction mechanisms ; IPR001452 [SH3 domain] ; IPR011511[Variant SH3 domain] -- -- Q9CR11 YEATS domain-containing protein 4 Yeats4 233.6 227 200.3 203.3 195.8 214.3 1.07743723508314 0.240962834632936 0.10760382915502 Nonsignificant None -- -- YEATS domain-containing protein 4 -- -- Transcription initiation factor IIF, auxiliary subunit K Transcription ; IPR005033 [YEATS] -- -- A2ALK8 Tyrosine-protein phosphatase non-receptor type 3 Ptpn3 117.8 116.2 105.2 155.5 146.1 171.2 0.717428087986464 0.00588549120856279 -0.479093865614333 Nonsignificant None 3 Molecular Function:protein tyrosine phosphatase activity (GO:0004725),Molecular Function:protein binding (GO:0005515),Biological Process:protein dephosphorylation (GO:0006470) tyrosine-protein phosphatase non-receptor type 3 3.1.3.48 -- Protein tyrosine phosphatase PTPMEG, contains FERM domain T Signal transduction mechanisms ; IPR000242 [PTP type protein phosphatase] ; IPR001478[PDZ domain] ; IPR018979[FERM, N-terminal] ; IPR018980[FERM, C-terminal PH-like domain] ; IPR019748[FERM central domain] -- -- Q9JLM8 Serine/threonine-protein kinase DCLK1 Dclk1 174 168.3 183 207.8 198.7 217.9 0.841287636130685 0.00919692895364158 -0.249328952823195 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468),Biological Process:intracellular signal transduction (GO:0035556) doublecortin-like kinase 1/2 2.7.11.1 -- Microtubule assembly protein Doublecortin and related proteins, contain DCX domain DZ Cell cycle control, cell division, chromosome partitioning ; Cytoskeleton ; IPR000719 [Protein kinase domain] ; IPR003533[Doublecortin domain] -- -- Q8K013 GTP-binding protein 10 Gtpbp10 95.7 150.3 134.6 129.8 129.2 119.2 1.00634584875727 0.963849228096646 0.00912619832426057 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) -- -- -- Predicted GTP-binding protein (ODN superfamily) R General function prediction only ; IPR006073 [GTP binding domain] ; IPR006169[GTP1/OBG domain] -- -- A0A087WQM1 Glia-derived nexin (Fragment) Serpine2 97 94.5 81.3 79 76 69.5 1.21514476614699 0.0457044805565087 0.281128199395663 Nonsignificant None -- -- glia-derived nexin -- -- Serpin V Defense mechanisms ; IPR023796 [Serpin domain] -- -- Q8K327 Chromosome alignment-maintaining phosphoprotein 1 Champ1 310.7 290.7 288.8 261.7 285.4 281.4 1.07447193723597 0.112310821206746 0.103627803343455 Nonsignificant None -- -- -- -- -- FOG: Zn-finger R General function prediction only ; -- -- -- Q3UP48 Uncharacterized protein Hnf4g 11.1 7.3 10.2 9 0 10.3 0.987910189982729 0.945000601424951 -0.0175482012108472 Nonsignificant None 4 Cellular Component:nucleus (GO:0005634),Molecular Function:zinc ion binding (GO:0008270),Biological Process:steroid hormone mediated signaling pathway (GO:0043401),Molecular Function:sequence-specific DNA binding (GO:0043565) hepatocyte nuclear factor 4-gamma -- ko04950 Maturity onset diabetes of the young Hepatocyte nuclear factor 4 and similar steroid hormone receptors K Transcription ; IPR000536 [Nuclear hormone receptor, ligand-binding domain] ; IPR001628[Zinc finger, nuclear hormone receptor-type] -- RXR-like Q5NCR9 Nuclear speckle splicing regulatory protein 1 Nsrp1 259.6 261 245.4 203.9 206.6 212.6 1.22933718504253 0.00105295754453235 0.297880675246516 Nonsignificant None -- -- coiled-coil domain-containing protein 55 -- -- Uncharacterized conserved protein S Function unknown ; IPR018612 [Domain of unknown function DUF2040] -- -- Q3TMP1 General transcription factor IIIC, polypeptide 3 Gtf3c3 360.8 355.7 369.5 403.6 387.9 391.1 0.918315575849822 0.00676919437936461 -0.122938079072918 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) general transcription factor 3C polypeptide 3 (transcription factor C subunit 4) -- -- RNA polymerase III transcription factor TFIIIC K Transcription ; IPR019734 [Tetratricopeptide repeat] -- -- Q52KC5 Coiled-coil-helix-coiled-coil-helix domain containing 5 Chchd5 27.1 23.7 24.2 30.9 25.4 28.7 0.882352941176471 0.157178476564587 -0.180572245641821 Nonsignificant None -- -- -- -- -- -- -- -- IPR031731 [IMS import disulfide relay-system, CHCH-CHCH-like Cx9C] -- -- Q6ZQE7 MKIAA0270 protein (Fragment) Palm 35.4 37.8 33 52.7 50.2 49.3 0.697766097240473 0.000873016270885696 -0.519184592699392 Nonsignificant None 2 Biological Process:regulation of cell shape (GO:0008360),Cellular Component:membrane (GO:0016020) A-kinase anchor protein 2 -- -- -- -- -- IPR004965 [Paralemmin] -- -- Q5SSW2 Proteasome activator complex subunit 4 Psme4 224.6 176.3 172.8 156.9 157.9 158.4 1.21238377007608 0.182834146607656 0.27784644431218 Nonsignificant None -- -- proteasome activator subunit 4 -- ko03050 Proteasome Uncharacterized conserved protein S Function unknown ; IPR021843 [Protein of unknown function DUF3437] ; IPR032430[Proteasome activator Blm10, mid region] -- -- P56382 ATP synthase subunit epsilon, mitochondrial Atp5f1e 892 935.6 1066.9 1189.8 1119.8 1064.8 0.857782124229493 0.0662623804016949 -0.22131684367745 Nonsignificant None 1 Biological Process:ATP synthesis coupled proton transport (GO:0015986) F-type H+-transporting ATPase subunit epsilon -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Mitochondrial F1F0-ATP synthase, subunit epsilon/ATP15 C Energy production and conversion ; IPR006721 [ATP synthase, F1 complex, epsilon subunit, mitochondrial] -- -- E0CX98 Bax inhibitor 1 (Fragment) Tmbim6 560.7 531.9 689.9 540 506 564.1 1.10707409477672 0.326359303084938 0.146751782724392 Nonsignificant None -- -- Bax inhibitor 1 -- -- Bax-mediated apoptosis inhibitor TEGT/BI-1 V Defense mechanisms ; IPR006214 [Bax inhibitor 1-related] -- -- Q66JW2 Golga1 protein Golga1 332.2 336.1 274.5 260.3 262.2 275.4 1.18160170447425 0.0777347319173406 0.24074381232127 Nonsignificant None 2 Biological Process:protein targeting to Golgi (GO:0000042),Molecular Function:protein binding (GO:0005515) golgin subfamily A member 1 -- -- -- -- -- IPR000237 [GRIP domain] -- -- P61793 Lysophosphatidic acid receptor 1 Lpar1 286.7 298.3 328.3 379.6 380.5 433.4 0.76522832006703 0.0125606050995791 -0.386037828019572 Nonsignificant None 3 Molecular Function:G-protein coupled receptor activity (GO:0004930),Biological Process:G-protein coupled receptor signaling pathway (GO:0007186),Cellular Component:integral component of membrane (GO:0016021) lysophosphatidic acid receptor 1 -- ko04015 Rap1 signaling pathway ko04072 Phospholipase D signaling pathway ko04080 Neuroactive ligand-receptor interaction ko04151 PI3K-Akt signaling pathway ko04540 Gap junction ko05200 Pathways in cancer FOG: 7 transmembrane receptor R General function prediction only ; IPR000276 [G protein-coupled receptor, rhodopsin-like] -- -- Q52KC0 Ubiquitin protein ligase E3 component n-recognin 7 (Putative) Ubr7 228.5 213.1 202.8 182.8 193.6 201.9 1.11430053605395 0.0767153089766904 0.15613839192308 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) E3 ubiquitin-protein ligase UBR7 2.3.2.27 -- Uncharacterized conserved protein, contains N-recognin-type Zn-finger R General function prediction only ; IPR003126 [Zinc finger, UBR-type] -- -- Q8BGZ4 Cell division cycle protein 23 homolog Cdc23 78.3 81.8 94.2 82.4 80.8 89.2 1.00752773375594 0.913372687507866 0.0108195517075573 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Cellular Component:anaphase-promoting complex (GO:0005680),Biological Process:regulation of mitotic metaphase/anaphase transition (GO:0030071) anaphase-promoting complex subunit 8 -- ko04110 Cell cycle ko04114 Oocyte meiosis ko04120 Ubiquitin mediated proteolysis ko04914 Progesterone-mediated oocyte maturation ko05166 HTLV-I infection Anaphase-promoting complex (APC), Cdc23 subunit DO Cell cycle control, cell division, chromosome partitioning ; Posttranslational modification, protein turnover, chaperones ; IPR007192 [Cdc23] ; IPR011990[Tetratricopeptide-like helical domain] ; IPR019734[Tetratricopeptide repeat] -- -- Q09PK2 Retroviral-like aspartic protease 1 Asprv1 52.9 64.9 35.2 27.9 26.1 24.4 1.9515306122449 0.100264581723679 0.964606093464806 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- A0A1L1SV24 Predicted gene, 49373 (Fragment) Gm49373 29.8 41.7 35.2 34.6 39.2 50.9 0.855653568564555 0.370144904509739 -0.224901289005245 Nonsignificant None 2 Molecular Function:electron carrier activity (GO:0009055),Molecular Function:iron-sulfur cluster binding (GO:0051536) ferredoxin-2, mitochondrial -- -- Ferredoxin C Energy production and conversion ; IPR001041 [2Fe-2S ferredoxin-type iron-sulfur binding domain] -- -- Q5F2B4 Non-receptor tyrosine-protein kinase TNK1 Tnk1 184.8 177.2 186.3 132.7 177.4 168 1.14683120686049 0.167459478306217 0.197653067949105 Nonsignificant None 2 Molecular Function:protein kinase activity (GO:0004672),Biological Process:protein phosphorylation (GO:0006468) non-receptor tyrosine-protein kinase TNK1 2.7.10.2 -- ACK and related non-receptor tyrosine kinases T Signal transduction mechanisms ; IPR001245 [Serine-threonine/tyrosine-protein kinase catalytic domain] -- -- Q921Q3 Chitobiosyldiphosphodolichol beta-mannosyltransferase Alg1 14.2 15.3 17 16.9 11.8 16.8 1.02197802197802 0.867204264730423 0.0313641709093353 Nonsignificant None -- -- beta-1,4-mannosyltransferase 2.4.1.142 ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways Beta-1,4-mannosyltransferase O Posttranslational modification, protein turnover, chaperones ; IPR001296 [Glycosyl transferase, family 1] -- -- Q3THV8 Uncharacterized protein Rrm2 176.2 157.6 130.5 118.5 130.3 133.8 1.21353894406691 0.124665010491822 0.279220407220549 Nonsignificant None 1 Biological Process:oxidation-reduction process (GO:0055114) ribonucleoside-diphosphate reductase subunit M2 1.17.4.1 ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko00480 Glutathione metabolism ko01100 Metabolic pathways ko04115 p53 signaling pathway Ribonucleotide reductase, beta subunit F Nucleotide transport and metabolism ; IPR000358 [Ribonucleotide reductase small subunit family] -- -- E9Q8I7 Nuclear transcription factor, X-box-binding-like 1 Nfxl1 185.1 173.3 176.7 198.8 200.6 191.7 0.905261377093554 0.0136089938025898 -0.143593691649528 Nonsignificant None 2 Cellular Component:nucleus (GO:0005634),Molecular Function:zinc ion binding (GO:0008270) NF-X1-type zinc finger protein NFXL1 -- -- Transcription factor NF-X1, contains NFX-type Zn2+-binding and R3H domains K Transcription ; IPR000967 [Zinc finger, NF-X1-type] -- zf-NF-X1 Q9CPT5 Nucleolar protein 16 Nop16 508 536.4 509.4 415.4 418.6 443.3 1.21647224614421 0.00195546383493997 0.282703405515248 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019002 [Ribosome biogenesis protein Nop16] -- -- Q8BPP1 Protein mab-21-like 2 Mab21l2 592.3 600.6 802.8 924 939.5 794.5 0.750827689992476 0.0559568988241807 -0.41344623816798 Nonsignificant None -- -- -- -- -- Mab-21-like cell fate specification proteins T Signal transduction mechanisms ; IPR024810 [Mab-21 domain] -- -- Q8CG16 Complement C1r-A subcomponent C1ra 63.4 50.9 50.6 64.1 60.7 63.8 0.874337221633086 0.143898466597006 -0.193738277237629 Nonsignificant None 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) complement component 1, r subcomponent 3.4.21.41 ko04145 Phagosome ko04610 Complement and coagulation cascades ko05133 Pertussis ko05150 Staphylococcus aureus infection ko05322 Systemic lupus erythematosus Trypsin E Amino acid transport and metabolism ; IPR000436 [Sushi/SCR/CCP domain] ; IPR000859[CUB domain] ; IPR001254[Serine proteases, trypsin domain] -- -- A2AU35 Proteasome inhibitor PI31 subunit Psmf1 71.2 64 39 55.8 67.9 67.4 0.91156462585034 0.620939034761625 -0.133583154378592 Nonsignificant None -- -- proteasome inhibitor subunit 1 (PI31) -- ko03050 Proteasome Proteasome formation inhibitor PI31 O Posttranslational modification, protein turnover, chaperones ; IPR013886 [PI31 proteasome regulator, C-terminal] ; IPR021625[PI31 proteasome regulator, N-terminal] -- -- A0A2X0SYS9 ARHGAP18 (Fragment) ARHGAP18 318.8 277.4 303.6 387.7 411.4 379.1 0.763707350195213 0.00388990963629066 -0.388908186083579 Nonsignificant None 1 Biological Process:signal transduction (GO:0007165) Rho GTPase-activating protein 18/28/40 -- -- Tumour suppressor protein p122-RhoGAP/DLC1 T Signal transduction mechanisms ; IPR000198 [Rho GTPase-activating protein domain] -- -- Q3TM31 TIR domain-containing protein Tlr3 176 186.9 173.4 219 213.3 202.2 0.845232466509062 0.00705396351531778 -0.242579910704868 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Biological Process:signal transduction (GO:0007165) toll-like receptor 3 -- ko04217 Necroptosis ko04620 Toll-like receptor signaling pathway ko05160 Hepatitis C ko05161 Hepatitis B ko05164 Influenza A ko05165 Human papillomavirus infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection FOG: Toll/interleukin receptor and related proteins containing LRR and TIR repeats T Signal transduction mechanisms ; IPR000157 [Toll/interleukin-1 receptor homology (TIR) domain] ; IPR001611[Leucine-rich repeat] -- -- Q9CQ71 Replication protein A 14 kDa subunit Rpa3 383.5 327.6 338.2 296.1 304.3 327.3 1.13107685674248 0.106450589032212 0.177696963875896 Nonsignificant None 5 Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634),Biological Process:DNA replication (GO:0006260),Biological Process:DNA repair (GO:0006281),Biological Process:DNA recombination (GO:0006310) replication factor A3 -- ko03030 DNA replication ko03420 Nucleotide excision repair ko03430 Mismatch repair ko03440 Homologous recombination ko03460 Fanconi anemia pathway -- -- -- IPR013970 [Replication factor A protein 3] -- -- Q78XF5 Oligosaccharyltransferase complex subunit OSTC Ostc 284.2 265.6 264 263.2 277.1 257 1.02069484510222 0.565629352548411 0.0295516113079945 Nonsignificant None -- -- -- -- -- Predicted membrane protein S Function unknown ; IPR021149 [Oligosaccharyl transferase complex, subunit OST3/OST6] -- -- Q8BUY5 Complex I assembly factor TIMMDC1, mitochondrial Timmdc1 17.8 16.5 11 13.2 14 15.1 1.0709219858156 0.666837286739485 0.0988533869262855 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR003397 [Mitochondrial inner membrane translocase subunit Tim17/Tim22/Tim23/peroxisomal protein PMP24] -- -- Q3TWJ1 Retinoic acid receptor RXR-beta Rxrb 189.1 176.8 163.2 211.1 191.9 198 0.880366056572379 0.0630083865492676 -0.183824573191209 Nonsignificant None 4 Cellular Component:nucleus (GO:0005634),Molecular Function:zinc ion binding (GO:0008270),Biological Process:steroid hormone mediated signaling pathway (GO:0043401),Molecular Function:sequence-specific DNA binding (GO:0043565) retinoid X receptor beta -- ko03320 PPAR signaling pathway ko04659 Th17 cell differentiation ko04919 Thyroid hormone signaling pathway ko04920 Adipocytokine signaling pathway ko05200 Pathways in cancer ko05202 Transcriptional misregulation in cancer ko05216 Thyroid cancer ko05222 Small cell lung cancer ko05223 Non-small cell lung cancer ko05226 Gastric cancer FOG: Hormone receptors T Signal transduction mechanisms ; IPR000536 [Nuclear hormone receptor, ligand-binding domain] ; IPR001628[Zinc finger, nuclear hormone receptor-type] -- RXR-like Q7TNL9 Coiled-coil-helix-coiled-coil-helix domain-containing 10 Chchd10 28 25 43.4 59.2 50.8 55 0.584242424242424 0.0209855575180709 -0.775360972903216 Significant down -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; -- -- -- Q8K0X1 Vascular cell adhesion molecule 1 Vcam1 185.3 190 180.5 182.8 171.5 169.7 1.06068702290076 0.0980870775667905 0.0849990227757494 Nonsignificant None 2 Biological Process:cell adhesion (GO:0007155),Cellular Component:integral component of membrane (GO:0016021) vascular cell adhesion molecule 1 -- ko04064 NF-kappa B signaling pathway ko04514 Cell adhesion molecules (CAMs) ko04668 TNF signaling pathway ko04670 Leukocyte transendothelial migration ko04933 AGE-RAGE signaling pathway in diabetic complications ko05143 African trypanosomiasis ko05144 Malaria ko05166 HTLV-I infection ko05418 Fluid shear stress and atherosclerosis -- -- -- IPR008424 [Immunoglobulin C2-set] ; IPR013098[Immunoglobulin I-set] ; IPR013151[Immunoglobulin] -- -- Q8JZZ2 Wdtc1 protein Wdtc1 379.4 359.1 402.8 400.9 408.3 420.7 0.92796162289617 0.100534068227719 -0.107862952898998 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) WD and tetratricopeptide repeats protein 1 -- -- WD40 repeat protein R General function prediction only ; IPR001680 [WD40 repeat] -- -- Q8R138 Transmembrane protein 119 Tmem119 366.7 377.9 293.4 338.7 340.6 360.7 0.998076923076923 0.981765214590034 -0.00277708467057384 Nonsignificant None 1 Biological Process:ossification (GO:0001503) -- -- -- -- -- -- IPR031453 [Transmembrane protein 119] -- -- Q91Y74 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 St3gal4 542.4 513.3 490.2 397.9 427.4 414.7 1.2466935483871 0.00418900450698597 0.318106877712585 Nonsignificant None 2 Biological Process:protein glycosylation (GO:0006486),Molecular Function:sialyltransferase activity (GO:0008373) beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4C) 2.4.99.4 ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series ko01100 Metabolic pathways Sialyltransferase G Carbohydrate transport and metabolism ; IPR001675 [Glycosyl transferase family 29] -- -- Q920L1 Acyl-CoA (8-3)-desaturase Fads1 125 121.6 126.1 131.1 141.1 140.1 0.903953431967014 0.018791413400828 -0.145679642159215 Nonsignificant None 1 Biological Process:lipid metabolic process (GO:0006629) acyl-CoA (8-3)-desaturase (Delta-5 desaturase) 1.14.19.44 ko01040 Biosynthesis of unsaturated fatty acids ko01212 Fatty acid metabolism Delta 6-fatty acid desaturase/delta-8 sphingolipid desaturase I Lipid transport and metabolism ; IPR001199 [Cytochrome b5-like heme/steroid binding domain] ; IPR005804[Fatty acid desaturase domain] -- -- P56392 Cytochrome c oxidase subunit 7A1, mitochondrial Cox7a1 387 347.2 393.2 602 591.4 587.1 0.633192923336142 0.000133703871478456 -0.659282963109214 Significant down -- -- cytochrome c oxidase subunit 7a -- ko00190 Oxidative phosphorylation ko04260 Cardiac muscle contraction ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease -- -- -- -- -- -- Q8C5P5 5-nucleotidase domain-containing protein 1 Nt5dc1 265 270 258.5 194.2 205 212.3 1.29762878168438 0.000620091354616032 0.375877724307795 Nonsignificant None -- -- -- -- -- IMP-GMP specific 5'-nucleotidase F Nucleotide transport and metabolism ; IPR008380 [HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase] -- -- Q80SY6 Adenosine deaminase-like protein Adal 181.9 175.4 179.4 203.1 202 192.6 0.897942111427137 0.00606192045013103 -0.155305654652541 Nonsignificant None 1 Molecular Function:deaminase activity (GO:0019239) -- -- -- Adenine deaminase/adenosine deaminase F Nucleotide transport and metabolism ; IPR001365 [Adenosine/AMP deaminase domain] -- -- P58501 PAX3- and PAX7-binding protein 1 Paxbp1 79.1 79.8 94.5 109.1 107.1 97.9 0.806749442852595 0.0293290873753424 -0.309807418511155 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634) GC-rich sequence DNA-binding factor -- -- Transcriptional regulators binding to the GC-rich sequences K Transcription ; IPR022783 [GC-rich sequence DNA-binding factor domain] -- -- F6R6F1 RalBP1-associated Eps domain-containing protein 1 (Fragment) Reps1 318.8 334.6 295.1 238.5 262.9 268.4 1.23213821771889 0.0154587398199924 0.301164102488 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) RalBP1-associated Eps domain-containing protein -- -- Ral-GTPase effector RALBP1 U Intracellular trafficking, secretion, and vesicular transport ; IPR000261 [EH domain] -- -- Q8C094 Stress-activated protein kinase JNK (Fragment) Mapk9 55.6 47.2 53.6 50.3 57 62.7 0.92 0.359964246389399 -0.120294233717712 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) c-Jun N-terminal kinase 2.7.11.24 ko01522 Endocrine resistance ko04010 MAPK signaling pathway ko04012 ErbB signaling pathway ko04014 Ras signaling pathway ko04024 cAMP signaling pathway ko04068 FoxO signaling pathway ko04071 Sphingolipid signaling pathway ko04137 Mitophagy - animal ko04140 Autophagy - animal ko04141 Protein processing in endoplasmic reticulum ko04210 Apoptosis ko04215 Apoptosis - multiple species ko04217 Necroptosis ko04310 Wnt signaling pathway ko04380 Osteoclast differentiation ko04510 Focal adhesion ko04530 Tight junction ko04620 Toll-like receptor signaling pathway ko04621 NOD-like receptor signaling pathway ko04622 RIG-I-like receptor signaling pathway ko04657 IL-17 signaling pathway ko04658 Th1 and Th2 cell differentiation ko04659 Th17 cell differentiation ko04664 Fc epsilon RI signaling pathway ko04668 TNF signaling pathway ko04722 Neurotrophin signaling pathway ko04723 Retrograde endocannabinoid signaling ko04728 Dopaminergic synapse ko04750 Inflammatory mediator regulation of TRP channels ko04910 Insulin signaling pathway ko04912 GnRH signaling pathway ko04914 Progesterone-mediated oocyte maturation ko04917 Prolactin signaling pathway ko04920 Adipocytokine signaling pathway ko04926 Relaxin signaling pathway ko04930 Type II diabetes mellitus ko04931 Insulin resistance ko04932 Non-alcoholic fatty liver disease (NAFLD) ko04933 AGE-RAGE signaling pathway in diabetic complications ko05132 Salmonella infection ko05133 Pertussis ko05142 Chagas disease (American trypanosomiasis) ko05145 Toxoplasmosis ko05152 Tuberculosis ko05160 Hepatitis C ko05161 Hepatitis B ko05164 Influenza A ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05210 Colorectal cancer ko05212 Pancreatic cancer ko05231 Choline metabolism in cancer ko05418 Fluid shear stress and atherosclerosis Jun-N-terminal kinase (JNK) T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q8CHP6 Polyhomeotic-like protein 3 Phc3 128.4 97.4 86.8 91.8 99 98.9 1.07904729030031 0.580391603745571 0.109758093729261 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) polyhomeotic-like protein 3 -- -- -- -- -- IPR001660 [Sterile alpha motif domain] -- -- Q3UTB3 Tyrosine 3-monooxygenase Th 89.8 88.8 81.6 96.5 92 93.3 0.923349893541519 0.0685356384706532 -0.115050649591841 Nonsignificant None 1 Biological Process:oxidation-reduction process (GO:0055114) tyrosine 3-monooxygenase 1.14.16.2 ko00350 Tyrosine metabolism ko00790 Folate biosynthesis ko01100 Metabolic pathways ko04728 Dopaminergic synapse ko04917 Prolactin signaling pathway ko05012 Parkinson's disease ko05030 Cocaine addiction ko05031 Amphetamine addiction ko05034 Alcoholism Aromatic amino acid hydroxylase E Amino acid transport and metabolism ; IPR019774 [Aromatic amino acid hydroxylase, C-terminal] -- -- Q80VC9 Calmodulin-regulated spectrin-associated protein 3 Camsap3 125.3 124.8 126.7 117.8 102.3 124.6 1.09312445604874 0.245770848710544 0.128457666245514 Nonsignificant None 4 Molecular Function:calmodulin binding (GO:0005516),Molecular Function:microtubule binding (GO:0008017),Molecular Function:spectrin binding (GO:0030507),Biological Process:neuron projection development (GO:0031175) calmodulin-regulated spectrin-associated protein -- -- Uncharacterized CH domain protein Z Cytoskeleton ; IPR014797 [CKK domain] ; IPR022613[Calmodulin-regulated spectrin-associated protein, CH domain] ; IPR031372[CAMSAP, spectrin and Ca2+/calmodulin-binding region] -- -- D6RIQ3 Phytanoyl-CoA dioxygenase domain-containing protein 1 Phyhd1 77.2 83.4 59.1 73.5 77.3 78.7 0.957298474945534 0.683817881722971 -0.0629592838778938 Nonsignificant None -- -- -- -- -- Peroxisomal phytanoyl-CoA hydroxylase I Lipid transport and metabolism ; IPR008775 [Phytanoyl-CoA dioxygenase] -- -- Q52KR3 Protein prune homolog 2 Prune2 120.5 106.2 106.6 125.2 134.7 112.3 0.895486297689414 0.181008494730913 -0.159256737948903 Nonsignificant None 2 Cellular Component:cytoplasm (GO:0005737),Molecular Function:pyrophosphatase activity (GO:0016462) prune homolog 2 -- -- -- -- -- IPR001251 [CRAL-TRIO lipid binding domain] ; IPR004097[DHHA2 domain] ; IPR022181[Bcl2-/adenovirus E1B 19kDa-interacting protein 2] -- -- Q9R0C0 Biogenesis of lysosome-related organelles complex 1 subunit 6 Bloc1s6 16.4 16.8 18.4 14 16.2 16.4 1.10729613733906 0.164912444737219 0.147041110768974 Nonsignificant None -- -- biogenesis of lysosome-related organelles complex 1 subunit 6 -- -- -- -- -- IPR028119 [Snapin/Pallidin/Snn1] -- -- Q9D7J4 Cytochrome c oxidase assembly protein COX20, mitochondrial Cox20 77.4 80.6 85.7 89.4 81.7 82.1 0.962480252764613 0.414210847926048 -0.0551711537050007 Nonsignificant None -- -- cytochrome c oxidase assembly protein subunit 20 -- -- -- -- -- IPR022533 [Cox20/FAM36A] -- -- A2CG76 Histone-lysine N-methyltransferase EHMT2 Ehmt2 238.3 244 213.8 202.3 202 229.8 1.09777637596594 0.188932624936931 0.134584198111107 Nonsignificant None 5 Molecular Function:protein binding (GO:0005515),Cellular Component:nucleus (GO:0005634),Molecular Function:zinc ion binding (GO:0008270),Molecular Function:histone-lysine N-methyltransferase activity (GO:0018024),Biological Process:histone lysine methylation (GO:0034968) euchromatic histone-lysine N-methyltransferase 2.1.1.43 ko00310 Lysine degradation ko04211 Longevity regulating pathway Histone H3 (Lys9) methyltransferase SUV39H1/Clr4, required for transcriptional silencing BK Chromatin structure and dynamics ; Transcription ; IPR001214 [SET domain] ; IPR007728[Pre-SET domain] ; IPR020683[Ankyrin repeat-containing domain] -- -- Q8BYM8 Probable cysteine--tRNA ligase, mitochondrial Cars2 16.9 15.9 18.1 18.9 18.2 20.5 0.883680555555556 0.074562420719971 -0.178403155366617 Nonsignificant None -- -- cysteinyl-tRNA synthetase 6.1.1.16 ko00970 Aminoacyl-tRNA biosynthesis Cysteinyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR032678 [tRNA synthetases class I, catalytic domain] -- -- Q9QXM0 Monoacylglycerol lipase ABHD2 Abhd2 132.1 134.8 140.9 155.5 180.7 146.8 0.844306418219462 0.0752593568876876 -0.244161413706539 Nonsignificant None -- -- abhydrolase domain-containing protein 2 -- -- Alpha/beta hydrolase R General function prediction only ; IPR000073 [Alpha/beta hydrolase fold-1] -- -- D3Z4C9 Ubiquinol-cytochrome-c reductase complex assembly factor 2 Uqcc2 65.5 65.1 51.7 58.4 68.6 84.8 0.860717658168083 0.332367198220515 -0.216388027953202 Nonsignificant None -- -- mitochondrial nucleoid factor 1 -- -- -- -- -- -- -- -- Q9DCJ1 Target of rapamycin complex subunit LST8 Mlst8 257.9 284.7 279.1 301.4 275.1 326.6 0.909866017052375 0.184899239968497 -0.136273978988568 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) target of rapamycin complex subunit LST8 -- ko04136 Autophagy - other ko04140 Autophagy - animal ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway G-protein beta subunit-like protein (contains WD40 repeats) R General function prediction only ; IPR001680 [WD40 repeat] -- -- D3YYB2 THUMP domain-containing protein 3 (Fragment) Thumpd3 140.1 129.7 145.9 151 143.3 151.6 0.93227180982283 0.137937548515733 -0.101177451689532 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q8K2H2 Deubiquitinase OTUD6B Otud6b 56.6 57.5 64.6 81.8 77.5 73.9 0.766295025728988 0.00596388002124093 -0.384028154159006 Nonsignificant None -- -- OTU domain-containing protein 6 3.4.19.12 -- OTU (ovarian tumor)-like cysteine protease TO Signal transduction mechanisms ; Posttranslational modification, protein turnover, chaperones ; IPR003323 [OTU domain] -- -- Q8BJZ0 Zinc finger MYND domain-containing protein 11 Zmynd11 69.4 53.7 85.4 91.4 82.6 82.1 0.814135103475205 0.175006822579678 -0.296659869265442 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- PHD Zn-finger protein R General function prediction only ; IPR000313 [PWWP domain] ; IPR001487[Bromodomain] -- -- P98203 Splicing regulator ARVCF Arvcf 10 11.3 10.7 13 17.5 15.1 0.701754385964912 0.0285656747893632 -0.510961919277379 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Neural adherens junction protein Plakophilin and related Armadillo repeat proteins TW Signal transduction mechanisms ; Extracellular structures ; IPR000225 [Armadillo] -- -- Q6PE15 Palmitoyl-protein thioesterase ABHD10, mitochondrial Abhd10 168.9 179 169.8 221 212.9 211.2 0.802511238567664 0.00065726118653517 -0.317406498649551 Nonsignificant None -- -- abhydrolase domain-containing protein 10 3.1.1.93 -- -- -- -- IPR000073 [Alpha/beta hydrolase fold-1] -- -- D6RCI4 RIKEN cDNA 2410004B18 gene 2410004B18Rik 700.9 823.6 335.5 556.8 626.9 563.1 1.06480421341882 0.82197692955859 0.090588185102501 Nonsignificant None -- -- -- -- -- -- -- -- IPR029089 [Protein of unknown function DUF4660] -- -- Q8BSF4 Phosphatidylserine decarboxylase proenzyme, mitochondrial Pisd 578.8 609.7 457.2 636.4 707.9 525 0.880383031081153 0.351247953850469 -0.183796756576335 Nonsignificant None 2 Molecular Function:phosphatidylserine decarboxylase activity (GO:0004609),Biological Process:phospholipid biosynthetic process (GO:0008654) phosphatidylserine decarboxylase 4.1.1.65 ko00564 Glycerophospholipid metabolism ko01100 Metabolic pathways Phosphatidylserine decarboxylase I Lipid transport and metabolism ; IPR003817 [Phosphatidylserine decarboxylase-related] -- -- A2CF83 RIKEN cDNA 0610010K14 gene 0610010K14Rik 244.3 233 230 230.2 230.9 225.8 1.02969864609113 0.216413127059409 0.0422221768232055 Nonsignificant None -- -- -- -- -- Predicted DNA-binding protein, contains SANT domain R General function prediction only ; -- -- -- Q3UMX3 Mic1 domain-containing protein Rmc1 132.3 113.3 129.7 127.6 138.9 128.4 0.950367181564953 0.401853399305659 -0.0734430775733726 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR009755 [Colon cancer-associated Mic1-like] -- -- B2RXU3 ADP-ribosylation factor-like 6 interacting protein 6 Arl6ip6 357 368.3 362.4 306.9 328.3 355.6 1.0977997577715 0.0893255220875201 0.134614926095816 Nonsignificant None -- -- -- -- -- -- -- -- IPR029383 [ADP-ribosylation factor-like protein 6-interacting protein 6] -- -- A0A494B9B0 N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) (Fragment) Acy3 38.1 31.4 55.5 81 56.1 62.2 0.627195183140993 0.075481171711478 -0.673013615289609 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) N-acyl-aromatic-L-amino acid amidohydrolase 3.5.1.114 -- -- -- -- IPR007036 [Succinylglutamate desuccinylase/aspartoacylase] -- -- Q80TA9 Ectopic P granules protein 5 homolog Epg5 53.5 52.9 47.5 51.7 43.4 45.9 1.09148936170213 0.23918196924487 0.126298069042054 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; -- -- -- E9PV48 Interferon-induced protein with tetratricopeptide repeats 3B Ifit3b 56.7 53.2 56.3 80.2 82.6 89.3 0.659262197540659 0.000621675218337274 -0.601075736088195 Significant down 1 Molecular Function:protein binding (GO:0005515) -- -- -- FOG: TPR repeat R General function prediction only ; IPR019734 [Tetratricopeptide repeat] -- -- Q3UYV4 SAND domain-containing protein Gmeb1 53.4 42.2 39 50.5 43.4 58.8 0.881466928618206 0.387934803794579 -0.182021652186534 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) -- -- -- Nuclear DEAF-1 related transcriptional regulator (suppressin) and related SAND domain proteins DK Cell cycle control, cell division, chromosome partitioning ; Transcription ; IPR000770 [SAND domain] -- SAND Z4YK56 Expressed sequence AU040320 AU040320 237.9 241.6 275.6 216.4 229.6 244.3 1.09387222946545 0.20934224459237 0.12944423293689 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q8BHH8 Clarin-3 Clrn3 73.3 67.6 90.1 105.8 109.1 115.7 0.698729582577132 0.0107023263962036 -0.517193872988894 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q8R2L5 28S ribosomal protein S18c, mitochondrial Mrps18c 86.1 85.7 192.6 204.8 217.1 208.1 0.578412698412698 0.129057380647632 -0.789828869472591 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S18 -- ko03010 Ribosome Mitochondrial/chloroplast ribosomal protein S18 J Translation, ribosomal structure and biogenesis ; IPR001648 [Ribosomal protein S18] -- -- Q8BGR6 ADP-ribosylation factor-like protein 15 Arl15 51.9 50.6 76.4 55.8 60.7 63.4 0.99444135630906 0.971212059397837 -0.00804179919957413 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) ADP-ribosylation factor-like protein 15 -- -- GTP-binding ADP-ribosylation factor Arf6 (dArf3) U Intracellular trafficking, secretion, and vesicular transport ; IPR006689 [Small GTPase superfamily, ARF/SAR type] -- -- E9QMH1 DNA dC->dU-editing enzyme APOBEC-3 Apobec3 19.3 25.3 15.7 14.7 23 18.5 1.0729537366548 0.729681565087206 0.101587871679159 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) C->U-editing enzyme APOBEC3 3.5.4.- -- -- -- -- IPR013158 [APOBEC-like, N-terminal] -- -- P70315 Actin nucleation-promoting factor WAS Was 111.4 145.2 106.9 110.1 113.9 112.5 1.08023774145617 0.534522297359647 0.111348859309277 Nonsignificant None 1 Molecular Function:actin binding (GO:0003779) Wiskott-Aldrich syndrome protein -- ko04062 Chemokine signaling pathway ko04144 Endocytosis ko04520 Adherens junction ko04530 Tight junction ko04666 Fc gamma R-mediated phagocytosis ko04810 Regulation of actin cytoskeleton ko05100 Bacterial invasion of epithelial cells ko05132 Salmonella infection ko05231 Choline metabolism in cancer Actin regulatory protein (Wiskott-Aldrich syndrome protein) TZ Signal transduction mechanisms ; Cytoskeleton ; IPR000095 [CRIB domain] ; IPR000697[WH1/EVH1 domain] ; IPR003124[WH2 domain] -- -- Q62415 Apoptosis-stimulating of p53 protein 1 Ppp1r13b 58.1 53 61.5 59.8 51.5 54.2 1.0429003021148 0.533221012780557 0.0606012474843749 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) apoptosis-stimulating of p53 protein 1 -- -- p53-interacting protein 53BP/ASPP, contains ankyrin and SH3 domains D Cell cycle control, cell division, chromosome partitioning ; IPR001452 [SH3 domain] ; IPR020683[Ankyrin repeat-containing domain] -- -- Q9ES52 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 Inpp5d 36.9 40.2 45.9 33.8 43.8 40.6 1.04060913705584 0.706166009376402 0.0574282800490699 Nonsignificant None -- -- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 3.1.3.86 ko00562 Inositol phosphate metabolism ko04070 Phosphatidylinositol signaling system ko04662 B cell receptor signaling pathway ko04664 Fc epsilon RI signaling pathway ko04666 Fc gamma R-mediated phagocytosis Inositol polyphosphate 5-phosphatase and related proteins U Intracellular trafficking, secretion, and vesicular transport ; IPR000980 [SH2 domain] ; IPR005135[Endonuclease/exonuclease/phosphatase] -- -- A0A1S6GWH7 BZIP domain-containing protein Maff 289.4 298.5 286.8 253.8 250.8 271.4 1.12719072164948 0.0109670282561376 0.172731641418306 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634) transcription factor MAFF/G/K -- -- bZIP transcription factor MafK K Transcription ; IPR004826 [Basic leucine zipper domain, Maf-type] -- TF_bZIP Q7TMY4 THO complex subunit 7 homolog Thoc7 596.1 604.5 603.4 565 606.3 548.8 1.04877623393989 0.242149150479393 0.0687068984854726 Nonsignificant None 2 Cellular Component:THO complex part of transcription export complex (GO:0000445),Biological Process:mRNA processing (GO:0006397) THO complex subunit 7 -- ko03013 RNA transport Uncharacterized conserved protein S Function unknown ; IPR008501 [THO complex subunit 7/Mft1] -- -- Q9JL16 Interferon-stimulated gene 20 kDa protein Isg20 281.8 344.3 258.8 260.5 252.3 232.9 1.18667024272496 0.158713004546457 0.246919088072023 Nonsignificant None -- -- interferon-stimulated gene 20 kDa protein 3.1.13.1 -- 3'-5' exonuclease L Replication, recombination and repair ; IPR013520 [Exonuclease, RNase T/DNA polymerase III] -- -- A0A1B0GR76 DNA helicase Chd9 29.8 27.6 28.3 22.4 26.9 30.4 1.07528230865747 0.452331036446864 0.104715480122028 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) chromodomain-helicase-DNA-binding protein 9 3.6.4.12 -- Chromodomain-helicase DNA-binding protein K Transcription ; IPR000330 [SNF2-related, N-terminal domain] ; IPR001650[Helicase, C-terminal] ; IPR023780[Chromo domain] -- -- Q99LH2 Phosphatidylserine synthase 1 Ptdss1 96 82.5 123.6 129 132.3 129.2 0.773623559539053 0.134080469879202 -0.370296364301401 Nonsignificant None 1 Biological Process:phosphatidylserine biosynthetic process (GO:0006659) phosphatidylserine synthase 1 2.7.8.- ko00564 Glycerophospholipid metabolism ko01100 Metabolic pathways Phosphatidylserine synthase I Lipid transport and metabolism ; IPR004277 [Phosphatidyl serine synthase] -- -- Q80ZQ9 Protein Abitram Abitram 80.4 74 83.5 71.8 81.3 69.5 1.06873315363881 0.326762434123312 0.0959016790831749 Nonsignificant None -- -- -- -- -- Predicted glycine cleavage system H protein E Amino acid transport and metabolism ; IPR033753 [Glycine cleavage system H-protein/Simiate] -- -- Q9CYX7 RRP15-like protein Rrp15 476.1 457.9 604.7 563.8 522 547.1 0.942311225427154 0.546877769352677 -0.0857244647477763 Nonsignificant None 1 Biological Process:rRNA processing (GO:0006364) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR012459 [Ribosomal RNA-processing protein 15] -- -- A0A140T8Q3 Immunoglobulin kappa chain variable 6-17 (Fragment) Igkv6-17 347.9 336.8 284.9 213.9 198.9 236.2 1.4939907550077 0.00860938330136835 0.57917122058645 Nonsignificant None -- -- pre-B lymphocyte gene -- -- -- -- -- IPR013106 [Immunoglobulin V-set domain] -- -- A2BIB5 ETS homologous factor Ehf 283.4 295.9 259.6 243.6 242.7 225.1 1.1792240652235 0.0254793407757198 0.237837871900046 Nonsignificant None 2 Cellular Component:nucleus (GO:0005634),Molecular Function:sequence-specific DNA binding (GO:0043565) ETS homologous factor -- -- Transcription factor NERF and related proteins, contain ETS domain K Transcription ; IPR000418 [Ets domain] ; IPR003118[Pointed domain] -- ETS Q99N85 28S ribosomal protein S18a, mitochondrial Mrps18a 294.7 295.1 368.7 350.1 351.8 343.1 0.917224880382775 0.361744443776575 -0.124652605300095 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S18 -- ko03010 Ribosome Mitochondrial/chloroplast ribosomal protein S18 J Translation, ribosomal structure and biogenesis ; IPR001648 [Ribosomal protein S18] -- -- Q8BLL4 Peptidase_M3 domain-containing protein Mipep 80.1 77.1 92.9 49.3 53.4 58.2 1.55438160348042 0.00561397568314395 0.636340731457524 Significant up 2 Molecular Function:metalloendopeptidase activity (GO:0004222),Biological Process:proteolysis (GO:0006508) mitochondrial intermediate peptidase 3.4.24.59 -- Metalloendopeptidase family - mitochondrial intermediate peptidase O Posttranslational modification, protein turnover, chaperones ; IPR001567 [Peptidase M3A/M3B catalytic domain] -- -- A0A087WNT2 Lymphocyte antigen 6E (Fragment) Ly6e 156.7 155 125.3 125.6 147.2 134.1 1.07397394937331 0.449267890902106 0.10295899931425 Nonsignificant None -- -- lymphocyte antigen 6 complex locus protein D/E/G6/H -- -- -- -- -- IPR016054 [Ly-6 antigen/uPA receptor-like] -- -- Q80T85 DDB1- and CUL4-associated factor 5 Dcaf5 156 144.3 166.2 163.4 158.6 157.2 0.973497495826377 0.556136657161733 -0.0387508270496645 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) WD repeat-containing protein 22 -- -- WD40 repeat protein R General function prediction only ; IPR001680 [WD40 repeat] -- -- B1AQD4 Ras-related protein Rab-34 (Fragment) Rab34 40.2 38.4 47.8 50.3 53.7 51.6 0.812339331619537 0.0330481559907905 -0.299845596809089 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-34 -- -- GTPase Rab6/YPT6/Ryh1, small G protein superfamily U Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- Q8K3L3 3-phosphoinositide-dependent protein kinase 1 Pdpk1 245.4 352.6 333 316.1 312.6 318.9 0.982482059940903 0.882198574118255 -0.0254970307940751 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) 3-phosphoinositide dependent protein kinase-1 2.7.11.1 ko01524 Platinum drug resistance ko03320 PPAR signaling pathway ko04068 FoxO signaling pathway ko04071 Sphingolipid signaling pathway ko04140 Autophagy - animal ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04152 AMPK signaling pathway ko04210 Apoptosis ko04510 Focal adhesion ko04660 T cell receptor signaling pathway ko04664 Fc epsilon RI signaling pathway ko04722 Neurotrophin signaling pathway ko04910 Insulin signaling pathway ko04919 Thyroid hormone signaling pathway ko04931 Insulin resistance ko04960 Aldosterone-regulated sodium reabsorption ko05145 Toxoplasmosis ko05160 Hepatitis C ko05205 Proteoglycans in cancer ko05213 Endometrial cancer ko05215 Prostate cancer ko05223 Non-small cell lung cancer ko05231 Choline metabolism in cancer 3-phosphoinositide-dependent protein kinase (PDK1) T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR033931[PDK1-type, PH domain] -- -- Q8BYI6 Lysophosphatidylcholine acyltransferase 2 Lpcat2 83.9 80 84.1 76.3 74 85.1 1.053525913339 0.312375960160074 0.0752258002357935 Nonsignificant None 2 Molecular Function:calcium ion binding (GO:0005509),Biological Process:metabolic process (GO:0008152) -- -- ko00564 Glycerophospholipid metabolism ko00565 Ether lipid metabolism ko01100 Metabolic pathways Predicted phosphate acyltransferase, contains PlsC domain I Lipid transport and metabolism ; IPR002048 [EF-hand domain] ; IPR002123[Phospholipid/glycerol acyltransferase] -- -- Q5S006 Leucine-rich repeat serine/threonine-protein kinase 2 Lrrk2 41.4 46.5 21.7 28.7 24.5 35.6 1.23423423423423 0.446688374944872 0.303616216610421 Nonsignificant None 6 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Molecular Function:GTP binding (GO:0005525),Biological Process:protein phosphorylation (GO:0006468),Biological Process:small GTPase mediated signal transduction (GO:0007264) leucine-rich repeat kinase 2 2.7.11.1 ko05012 Parkinson's disease -- -- -- IPR000719 [Protein kinase domain] ; IPR001611[Leucine-rich repeat] ; IPR013684[Mitochondrial Rho-like] ; IPR025875[Leucine rich repeat 4] ; IPR032171[C-terminal of Roc (COR) domain] -- -- B1AY86 Plexin domain-containing protein 2 Plxdc2 76.1 81.6 83.3 106.2 90.7 100.2 0.811174688657018 0.0202287118999531 -0.301915458718091 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) -- -- -- Extracellular protein TEM7, contains PSI domain (tumor endothelial marker in humans) W Extracellular structures ; IPR002165 [Plexin repeat] -- -- Q3TCL6 Anthrax toxin receptor Antxr2 332.9 363 452.5 453.1 444.9 447.6 0.853448275862069 0.208251935428028 -0.228624375047963 Nonsignificant None 2 Molecular Function:receptor activity (GO:0004872),Cellular Component:integral component of membrane (GO:0016021) anthrax toxin receptor -- ko04621 NOD-like receptor signaling pathway -- -- -- IPR002035 [von Willebrand factor, type A] ; IPR008399[Anthrax toxin receptor, C-terminal] ; IPR008400[Anthrax toxin receptor, extracellular] -- -- Q91XU2 Phosphatidyl inositol phosphate kinase type II beta (Fragment) Pip4k2b 64.9 70.8 69.8 60.9 55.9 68.6 1.1084142394822 0.179153466942958 0.148497149943515 Nonsignificant None 2 Molecular Function:phosphatidylinositol phosphate kinase activity (GO:0016307),Biological Process:phosphatidylinositol metabolic process (GO:0046488) 1-phosphatidylinositol-5-phosphate 4-kinase 2.7.1.149 ko00562 Inositol phosphate metabolism ko04070 Phosphatidylinositol signaling system ko04810 Regulation of actin cytoskeleton Phosphatidylinositol-4-phosphate 5-kinase T Signal transduction mechanisms ; IPR002498 [Phosphatidylinositol-4-phosphate 5-kinase, core] -- -- Q8BR90 RAB7A-interacting MON1-CCZ1 complex subunit 1 Rimoc1 49.1 47.3 39.3 46.4 42.5 51.4 0.967213114754098 0.718525625773669 -0.0480942882010449 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q61687 Transcriptional regulator ATRX Atrx 52.8 52.8 65.7 49.5 51.7 41.9 1.19706498951782 0.146416515843426 0.259501479357331 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) transcriptional regulator ATRX 3.6.4.12 -- Transcription regulator XNP/ATRX, DEAD-box superfamily K Transcription ; IPR000330 [SNF2-related, N-terminal domain] ; IPR001650[Helicase, C-terminal] -- -- P39429 TNF receptor-associated factor 2 Traf2 43.1 47.2 45.1 42.3 40.7 43.7 1.06866614048934 0.119242622774701 0.0958112144341873 Nonsignificant None 2 Molecular Function:zinc ion binding (GO:0008270),Molecular Function:metal ion binding (GO:0046872) TNF receptor-associated factor 2 2.3.2.27 ko04010 MAPK signaling pathway ko04064 NF-kappa B signaling pathway ko04071 Sphingolipid signaling pathway ko04141 Protein processing in endoplasmic reticulum ko04210 Apoptosis ko04217 Necroptosis ko04380 Osteoclast differentiation ko04621 NOD-like receptor signaling pathway ko04622 RIG-I-like receptor signaling pathway ko04657 IL-17 signaling pathway ko04668 TNF signaling pathway ko04920 Adipocytokine signaling pathway ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05160 Hepatitis C ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05222 Small cell lung cancer TNF receptor-associated factor T Signal transduction mechanisms ; IPR001293 [Zinc finger, TRAF-type] ; IPR018957[Zinc finger, C3HC4 RING-type] ; IPR032070[TNF receptor-associated factor, BIRC3 binding domain] -- -- E9QP59 Inner nuclear membrane protein Man1 Lemd3 252.4 254.7 267.3 307.3 336.9 310.5 0.811144862260396 0.00454783112477269 -0.301968506706663 Nonsignificant None 1 Cellular Component:integral component of nuclear inner membrane (GO:0005639) inner nuclear membrane protein Man1 -- -- -- -- -- IPR003887 [LEM domain] ; IPR018996[Inner nuclear membrane protein MAN1] -- -- G3UZX2 Ubiquitin-conjugating enzyme E2 G2 (Fragment) Ube2g2 238.6 241 178.9 175 174.4 173.9 1.25836040512135 0.15670021356072 0.331545181529162 Nonsignificant None -- -- ubiquitin-conjugating enzyme E2 G2 2.3.2.23 ko04120 Ubiquitin mediated proteolysis ko04141 Protein processing in endoplasmic reticulum ko05012 Parkinson's disease Ubiquitin-protein ligase O Posttranslational modification, protein turnover, chaperones ; IPR000608 [Ubiquitin-conjugating enzyme E2] -- -- Q8VEH5 EPM2A-interacting protein 1 Epm2aip1 52 54.7 67.3 48.8 48.2 49.6 1.1869031377899 0.19151323322432 0.247202202602279 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q9CPS6 Adenosine 5-monophosphoramidase HINT3 Hint3 573.8 563.1 547 521.8 541.3 580.9 1.0242700729927 0.52356062387925 0.0345961661140509 Nonsignificant None -- -- -- -- -- Protein kinase C inhibitor-like protein R General function prediction only ; -- -- -- E9Q368 TAR RNA-binding protein 1 Tarbp1 18.6 11.8 21.7 16.3 14.9 21.6 0.986742424242424 0.950959033935332 -0.0192545570799453 Nonsignificant None 3 Molecular Function:RNA binding (GO:0003723),Biological Process:RNA processing (GO:0006396),Molecular Function:RNA methyltransferase activity (GO:0008173) tRNA guanosine-2'-O-methyltransferase 2.1.1.34 -- RNA Methylase, SpoU family A RNA processing and modification ; IPR001537 [tRNA/rRNA methyltransferase, SpoU type] -- -- P84309 Adenylate cyclase type 5 Adcy5 24.9 27.3 29.4 20.1 29.4 27.8 1.05562742561449 0.672823327801889 0.0781007380466483 Nonsignificant None 6 Molecular Function:adenylate cyclase activity (GO:0004016),Cellular Component:plasma membrane (GO:0005886),Biological Process:cAMP biosynthetic process (GO:0006171),Biological Process:cyclic nucleotide biosynthetic process (GO:0009190),Molecular Function:phosphorus-oxygen lyase activity (GO:0016849),Biological Process:intracellular signal transduction (GO:0035556) adenylate cyclase 5 4.6.1.1 ko00230 Purine metabolism ko01522 Endocrine resistance ko04015 Rap1 signaling pathway ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04062 Chemokine signaling pathway ko04072 Phospholipase D signaling pathway ko04114 Oocyte meiosis ko04211 Longevity regulating pathway ko04213 Longevity regulating pathway - multiple species ko04261 Adrenergic signaling in cardiomyocytes ko04270 Vascular smooth muscle contraction ko04371 Apelin signaling pathway ko04540 Gap junction ko04611 Platelet activation ko04713 Circadian entrainment ko04723 Retrograde endocannabinoid signaling ko04724 Glutamatergic synapse ko04725 Cholinergic synapse ko04726 Serotonergic synapse ko04727 GABAergic synapse ko04728 Dopaminergic synapse ko04750 Inflammatory mediator regulation of TRP channels ko04911 Insulin secretion ko04912 GnRH signaling pathway ko04913 Ovarian steroidogenesis ko04914 Progesterone-mediated oocyte maturation ko04915 Estrogen signaling pathway ko04916 Melanogenesis ko04918 Thyroid hormone synthesis ko04921 Oxytocin signaling pathway ko04923 Regulation of lipolysis in adipocytes ko04924 Renin secretion ko04925 Aldosterone synthesis and secretion ko04926 Relaxin signaling pathway ko04970 Salivary secretion ko04971 Gastric acid secretion ko04972 Pancreatic secretion ko04976 Bile secretion ko05012 Parkinson's disease ko05030 Cocaine addiction ko05031 Amphetamine addiction ko05032 Morphine addiction ko05034 Alcoholism ko05166 HTLV-I infection ko05200 Pathways in cancer ko05414 Dilated cardiomyopathy (DCM) Adenylate/guanylate cyclase C Energy production and conversion ; IPR001054 [Adenylyl cyclase class-3/4/guanylyl cyclase] ; IPR009398[Adenylate cyclase, conserved domain] ; IPR032628[Adenylate cyclase, N-terminal] -- -- Q9QZV9 NTF2-related export protein 1 Nxt1 43.6 45 51.9 50.5 56.5 55.7 0.863552550706822 0.080578314132721 -0.211644120564239 Nonsignificant None 2 Cellular Component:intracellular (GO:0005622),Biological Process:transport (GO:0006810) NTF2-related export protein 1/2 -- ko03008 Ribosome biogenesis in eukaryotes ko03013 RNA transport ko03015 mRNA surveillance pathway ko05164 Influenza A RNA export factor NXT1 A RNA processing and modification ; IPR002075 [Nuclear transport factor 2] -- -- B9EJR8 Dynein axonemal assembly factor 5 Dnaaf5 307.4 269.3 218.4 206.4 231.5 224.1 1.20105740181269 0.173602291438999 0.264305103026507 Nonsignificant None -- -- dynein assembly factor 5, axonemal -- -- -- -- -- IPR032878 [Vacuole morphology and inheritance protein 14, Fab1-binding region] -- -- Q9D786 HAUS augmin-like complex subunit 5 Haus5 118.4 124.8 110.7 100.5 110.4 105.6 1.11816745655608 0.0664710158270259 0.161136262109527 Nonsignificant None 2 Biological Process:spindle assembly (GO:0051225),Cellular Component:HAUS complex (GO:0070652) HAUS augmin-like complex subunit 5 -- -- -- -- -- IPR029131 [HAUS augmin-like complex subunit 5] -- -- A0A338P7L8 Charged multivesicular body protein 2b Chmp2b 518.5 566.2 364.9 575.2 631.9 523.8 0.837483390143856 0.241647902168483 -0.255867517199401 Nonsignificant None 1 Biological Process:vacuolar transport (GO:0007034) charged multivesicular body protein 2B -- ko04144 Endocytosis ko04217 Necroptosis Predicted assembly/vacuolar sorting protein U Intracellular trafficking, secretion, and vesicular transport ; IPR005024 [Snf7 family] -- -- A0A0R4J2B7 Dedicator of cytokinesis protein 10 (Fragment) Dock10 81.7 78.5 69 92.8 78.6 75.6 0.927935222672065 0.415142497481725 -0.107903997715135 Nonsignificant None -- -- dedicator of cytokinesis protein 9/10/11 -- -- PH domain-containing protein T Signal transduction mechanisms ; IPR010703 [Dedicator of cytokinesis, C-terminal] ; IPR027007[DHR-1 domain] -- -- Q8BYR2 Serine/threonine-protein kinase LATS1 Lats1 170.9 159.3 165.4 151.6 151.6 173.6 1.03942953020134 0.480401207455293 0.05579195167844 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) serine/threonine-protein kinase LATS1/2 2.7.11.1 ko04390 Hippo signaling pathway ko04392 Hippo signaling pathway - multiple species Warts/lats-like serine threonine kinases D Cell cycle control, cell division, chromosome partitioning ; IPR000719 [Protein kinase domain] ; IPR015940[Ubiquitin-associated domain] -- -- A0A0A6YWP9 Thioredoxin domain-containing protein 9 (Fragment) Txndc9 778.2 788.5 719.6 665.1 703.8 653.4 1.13054442960985 0.0287165575842025 0.177017690115335 Nonsignificant None 1 Biological Process:cell redox homeostasis (GO:0045454) -- -- -- ATP binding protein OC Posttranslational modification, protein turnover, chaperones ; Energy production and conversion ; IPR013766 [Thioredoxin domain] -- -- Q8K409 DNA polymerase beta Polb 156.3 182.5 231.3 197.4 176.1 196.1 1.00087780898876 0.994572755221548 0.00126585516666361 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634),Molecular Function:DNA polymerase activity (GO:0034061) -- -- ko03410 Base excision repair ko05166 HTLV-I infection ko05203 Viral carcinogenesis DNA polymerase IV (family X) L Replication, recombination and repair ; IPR010996 [DNA polymerase beta-like, N-terminal domain] ; IPR018944[DNA polymerase lambda, fingers domain] ; IPR028207[DNA polymerase beta, palm domain] ; IPR029398[DNA polymerase beta, thumb domain] -- -- Q99JP4 Anaphase-promoting complex subunit CDC26 Cdc26 290.4 293.3 314.9 296.7 297.2 276.8 1.03204318364534 0.415163378405094 0.0455033385204138 Nonsignificant None 3 Cellular Component:anaphase-promoting complex (GO:0005680),Biological Process:regulation of mitotic metaphase/anaphase transition (GO:0030071),Biological Process:anaphase-promoting complex-dependent catabolic process (GO:0031145) anaphase-promoting complex subunit 12 -- ko04110 Cell cycle ko04114 Oocyte meiosis ko04120 Ubiquitin mediated proteolysis ko04914 Progesterone-mediated oocyte maturation ko05166 HTLV-I infection -- -- -- IPR018860 [Anaphase-promoting complex, subunit CDC26] -- -- F6T4M4 Serine/arginine repetitive matrix protein 1 (Fragment) Srrm1 241.7 301.1 194.5 310.4 345.2 247 0.81686239751828 0.261302828331603 -0.291835021580675 Nonsignificant None 1 Biological Process:mRNA processing (GO:0006397) serine/arginine repetitive matrix protein 1 -- ko03013 RNA transport ko03015 mRNA surveillance pathway Splicing coactivator SRm160/300, subunit SRm160 (contains PWI domain) AR RNA processing and modification ; General function prediction only ; IPR002483 [PWI domain] -- -- Q3TAH6 MANSC domain-containing protein Mansc1 69.6 72.3 69.2 79.2 78 82.4 0.881051752921536 0.00436308110350968 -0.18270132944163 Nonsignificant None -- -- -- -- -- -- -- -- IPR011106 [Seven cysteines, N-terminal] -- -- Q5PRF0 HEAT repeat-containing protein 5A Heatr5a 18.4 18.7 17.3 17.7 18.4 23 0.920473773265651 0.412889985681382 -0.119551478927193 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; -- -- -- G3X8R5 Transcriptional regulator QRICH1 Qrich1 17.1 20.1 26.4 27.3 18 24.8 0.907275320970043 0.608360208921166 -0.140387678726268 Nonsignificant None -- -- -- -- -- -- -- -- IPR021893 [Protein of unknown function DUF3504] -- -- Q14CF7 Connector enhancer of kinase suppressor of Ras 1 Cnksr1 78.6 69.8 71.4 74.1 88.3 78.6 0.912033195020747 0.22950512321483 -0.132841760168093 Nonsignificant None -- -- -- -- -- Membrane-associated guanylate kinase-interacting protein/connector enhancer of KSR-like F Nucleotide transport and metabolism ; IPR001849 [Pleckstrin homology domain] ; IPR017874[CRIC domain] -- -- A0A0J9YTR2 RIKEN cDNA 0610012G03 gene 0610012G03Rik 50.2 47.9 51.4 41.9 47.5 46.6 1.09926470588235 0.0895242130431343 0.136538832947766 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q3U7K7 RING-type E3 ubiquitin transferase Trim21 109.3 154.4 140.7 149.4 183.6 157.6 0.82429677945373 0.163665551874435 -0.278764236654587 Nonsignificant None 4 Molecular Function:protein binding (GO:0005515),Cellular Component:intracellular (GO:0005622),Molecular Function:zinc ion binding (GO:0008270),Molecular Function:metal ion binding (GO:0046872) tripartite motif-containing protein 21 2.3.2.27 ko05322 Systemic lupus erythematosus Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR000315 [B-box-type zinc finger] ; IPR003877[SPRY domain] ; IPR006574[SPRY-associated] ; IPR018957[Zinc finger, C3HC4 RING-type] -- -- A0A2I3BR72 Roundabout homolog 2 Robo2 116.2 93.4 113.2 118.7 99.4 119.1 0.95729537366548 0.645518479205151 -0.0629639576643019 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) roundabout, axon guidance receptor 2 -- ko04360 Axon guidance Axon guidance receptor Dscam T Signal transduction mechanisms ; IPR003961 [Fibronectin type III] ; IPR013098[Immunoglobulin I-set] -- -- Z4YNA3 MAU2 chromatid cohesion factor homolog Mau2 158.6 156.5 158.8 150.6 144.3 154.5 1.05451713395639 0.0559353736195124 0.0765825364526934 Nonsignificant None 1 Biological Process:mitotic sister chromatid cohesion (GO:0007064) MAternally affected uncoordination -- -- Uncharacterized conserved protein S Function unknown ; IPR019440 [Chromatid cohesion factor MAU2] -- -- Q91XL3 UDP-glucuronic acid decarboxylase 1 Uxs1 89.3 93.6 111.6 95.2 92.2 89.1 1.06509945750452 0.44290757175879 0.0909881535957536 Nonsignificant None 1 Molecular Function:UDP-glucuronate decarboxylase activity (GO:0048040) UDP-glucuronate decarboxylase 4.1.1.35 ko00520 Amino sugar and nucleotide sugar metabolism ko01100 Metabolic pathways dTDP-glucose 4-6-dehydratase/UDP-glucuronic acid decarboxylase GM Carbohydrate transport and metabolism ; Cell wall/membrane/envelope biogenesis ; IPR016040 [NAD(P)-binding domain] ; IPR021761[UDP-glucuronate decarboxylase N-terminal] -- -- Q99PM0 Microfibril-associated glycoprotein 1 Mfap2 160 250.4 241.8 339.7 350 216.5 0.719708673581991 0.176594964808533 -0.474515049764924 Nonsignificant None 1 Cellular Component:microfibril (GO:0001527) -- -- -- -- -- -- IPR008673 [Microfibril-associated glycoprotein] -- -- Q8BHE8 m-AAA protease-interacting protein 1, mitochondrial Maip1 114.6 107.8 136.6 130.3 112.6 126.4 0.972109396154887 0.753705949381444 -0.0408094184952001 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q9CQT5 Proteasome maturation protein Pomp 111.8 109 100.8 98.1 95.9 100.9 1.09053916581892 0.0689702442585701 0.125041584117192 Nonsignificant None -- -- proteasome maturation protein -- ko03050 Proteasome Proteasome maturation factor O Posttranslational modification, protein turnover, chaperones ; -- -- -- P05532 Mast/stem cell growth factor receptor Kit Kit 77.8 66.8 83 100.3 82.6 80.3 0.864741641337386 0.208411671911852 -0.20965893142866 Nonsignificant None 2 Molecular Function:protein kinase activity (GO:0004672),Biological Process:protein phosphorylation (GO:0006468) proto-oncogene tyrosine-protein kinase Kit 2.7.10.1 ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04060 Cytokine-cytokine receptor interaction ko04072 Phospholipase D signaling pathway ko04151 PI3K-Akt signaling pathway ko04640 Hematopoietic cell lineage ko04916 Melanogenesis ko05200 Pathways in cancer ko05221 Acute myeloid leukemia ko05224 Breast cancer ko05230 Central carbon metabolism in cancer Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases T Signal transduction mechanisms ; IPR001245 [Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR013151[Immunoglobulin] -- -- Q8VEB4 Phospholipase A2 group XV Pla2g15 239.4 238.1 249.2 241.2 256.3 224.1 1.00706762749446 0.872496691105687 0.0101605677289013 Nonsignificant None 2 Biological Process:lipid metabolic process (GO:0006629),Molecular Function:O-acyltransferase activity (GO:0008374) lysophospholipase III 3.1.1.5 ko00564 Glycerophospholipid metabolism ko04142 Lysosome Lecithin:cholesterol acyltransferase (LCAT)/Acyl-ceramide synthase I Lipid transport and metabolism ; IPR003386 [Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase] -- -- A2AI08 Taperin Tprn 166.4 178.1 194 209 214.2 186.1 0.883801083210241 0.115386012187981 -0.178206395585739 Nonsignificant None 1 Molecular Function:phosphatase binding (GO:0019902) -- -- -- -- -- -- IPR025903 [Phostensin/Taperin N-terminal domain] ; IPR025907[Phostensin/Taperin PP1-binding domain] -- -- E9PVB5 Tetratricopeptide repeat protein 17 Ttc17 126.5 119.7 115.1 118.7 120.9 123.1 0.99614006065619 0.901665981851411 -0.00557949053783638 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Uncharacterized conserved protein, contains TPR repeats S Function unknown ; IPR019734 [Tetratricopeptide repeat] -- -- Q3UD01 Ataxin-7-like protein 3B Atxn7l3b 714 705.9 857.2 737.8 762.5 648.3 1.05980638555338 0.515732870656698 0.0838007250570555 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q91X79 Chymotrypsin-like elastase family member 1 Cela1 244.3 196.6 202.8 315.9 607 304 0.524655636156166 0.186318787887277 -0.930557291191036 Nonsignificant None 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) pancreatic elastase I 3.4.21.36 -- Trypsin E Amino acid transport and metabolism ; IPR001254 [Serine proteases, trypsin domain] -- -- Q91ZN5 Adenosine 3-phospho 5-phosphosulfate transporter 1 Slc35b2 646.9 632.6 715.2 734.3 747.2 746.1 0.89544801580176 0.0396731771533115 -0.159318414236043 Nonsignificant None 1 Biological Process:transmembrane transport (GO:0055085) solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 -- -- UDP-galactose transporter related protein G Carbohydrate transport and metabolism ; IPR013657 [UAA transporter] -- -- Q3TC47 BAR domain-containing protein Bin3 84.8 74.2 83.3 68.6 81.5 72.4 1.08898876404494 0.262197952032486 0.122989068710224 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:cytoplasm (GO:0005737) bridging integrator 3 -- -- Amphiphysin U Intracellular trafficking, secretion, and vesicular transport ; IPR004148 [BAR domain] -- -- Q3V028 Ubiquitin carboxyl-terminal hydrolase CYLD Cyld 13.5 15 8.5 13.8 19.7 14.3 0.774058577405858 0.257060819952761 -0.369485347464436 Nonsignificant None 2 Biological Process:protein deubiquitination (GO:0016579),Molecular Function:thiol-dependent ubiquitinyl hydrolase activity (GO:0036459) ubiquitin thioesterase 3.4.19.12 ko04217 Necroptosis ko04380 Osteoclast differentiation ko04622 RIG-I-like receptor signaling pathway Familial cylindromatosis protein R General function prediction only ; IPR000938 [CAP Gly-rich domain] ; IPR001394[Peptidase C19, ubiquitin carboxyl-terminal hydrolase] -- -- A0A668H4Q1 Lymphocyte antigen 6G Ly6g 72.4 81.9 45.6 37.4 44.9 34.9 1.70563139931741 0.0708475509509109 0.77030590232238 Nonsignificant None -- -- lymphocyte antigen 6 complex locus protein D/E/G6/H -- -- -- -- -- IPR016054 [Ly-6 antigen/uPA receptor-like] -- -- Q8R0J7 Vacuolar protein sorting-associated protein 37B Vps37b 122 135.2 92.6 113.2 141.5 123.8 0.924174372523118 0.559678231684513 -0.113763010951441 Nonsignificant None -- -- ESCRT-I complex subunit VPS37 -- ko04144 Endocytosis Uncharacterized conserved protein S Function unknown ; IPR009851 [Modifier of rudimentary, Modr] -- -- Q3UI98 Uncharacterized protein Gtf3c5 279.8 286.4 332.5 366.3 367.8 328 0.846153846153846 0.061088189894443 -0.241008099503795 Nonsignificant None -- -- general transcription factor 3C polypeptide 5 (transcription factor C subunit 1) -- -- RNA polymerase III transcription factor (TF)IIIC subunit K Transcription ; IPR019136 [Transcription factor IIIC, subunit 5] -- -- Q9DC48 Pre-mRNA-processing factor 17 Cdc40 149.5 150.1 194.3 177.3 170.2 169.3 0.955688854489164 0.638669042824012 -0.0653871013154809 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) pre-mRNA-processing factor 17 -- ko03040 Spliceosome mRNA splicing factor S Function unknown ; IPR001680 [WD40 repeat] -- -- Q921X6 DNA-directed RNA polymerase III subunit RPC6 Polr3f 150.5 144.2 162.9 158.1 193 150.1 0.913008778930567 0.366061101059904 -0.131299362543471 Nonsignificant None 3 Molecular Function:DNA-directed 5'-3' RNA polymerase activity (GO:0003899),Cellular Component:DNA-directed RNA polymerase III complex (GO:0005666),Biological Process:regulation of transcription from RNA polymerase III promoter (GO:0006359) DNA-directed RNA polymerase III subunit RPC6 -- ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways ko03020 RNA polymerase ko04623 Cytosolic DNA-sensing pathway ko05169 Epstein-Barr virus infection RNA polymerase III, subunit C34 K Transcription ; IPR007832 [RNA polymerase Rpc34] -- -- Q6NXM5 4632419I22Rik protein Brip1os 47.3 48.9 41.2 48.2 49.9 41.7 0.982832618025751 0.826896258575942 -0.0249823565573365 Nonsignificant None -- -- -- -- -- -- -- -- IPR018154 [TLV/ENV coat polyprotein] -- -- Q3TV70 Nuclear receptor 2C2-associated protein Nr2c2ap 3.7 1.3 0 2.8 3.1 6.2 0.619834710743802 0.424734766435302 -0.690044546778714 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- A2AF67 Dedicator of cytokinesis protein 11 Dock11 145.3 155.4 135.2 138.6 160.1 147.4 0.977135171486214 0.710899731485031 -0.0333699444195772 Nonsignificant None -- -- dedicator of cytokinesis protein 9/10/11 -- -- PH domain-containing protein T Signal transduction mechanisms ; IPR001849 [Pleckstrin homology domain] ; IPR010703[Dedicator of cytokinesis, C-terminal] ; IPR027007[DHR-1 domain] -- -- Q8VEK0 Cell cycle control protein 50A Tmem30a 656.7 642 662.7 617.3 606.8 626.7 1.05975794251135 0.0118742667906906 0.0837347789231266 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) -- -- -- Cell cycle control protein DKT Cell cycle control, cell division, chromosome partitioning ; Transcription ; Signal transduction mechanisms ; IPR005045 [CDC50/LEM3 family] -- -- A2RSQ0 DENN domain-containing protein 5B Dennd5b 170.1 148.2 128.6 144.3 146.5 147.1 1.02055263758849 0.825945563956908 0.0293505949423591 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) DENN domain-containing protein 5 -- -- Uncharacterized conserved protein, contains DENN and RUN domains T Signal transduction mechanisms ; IPR001024 [PLAT/LH2 domain] ; IPR001194[DENN domain] ; IPR004012[RUN domain] ; IPR005112[dDENN domain] ; IPR005113[uDENN domain] -- -- A0A4E9FSP6 IgL2 (Fragment) IGLC2 319.2 267 226.4 236.9 263.1 247.2 1.08752676659529 0.478528235100691 0.121050909521426 Nonsignificant None -- -- immunoglobulin lambda-like polypeptide 1 -- -- -- -- -- IPR003597 [Immunoglobulin C1-set] -- -- Q8BJZ7 Thymocyte nuclear protein 1 Thyn1 417.9 430 427.5 458.5 465 445.7 0.931492842535787 0.00985976605378848 -0.102383411150183 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR002740 [EVE domain] -- -- Q8C7H1 Methylmalonic aciduria type A homolog, mitochondrial Mmaa 110.7 110.1 119.8 161.6 151.1 134.6 0.761457634697071 0.0136591925175867 -0.393164323326056 Nonsignificant None -- -- LAO/AO transport system kinase 2.7.-.- -- -- -- -- -- -- -- Q8R238 Serine dehydratase-like Sdsl 204.1 205.1 223.6 260.9 248.2 273.5 0.808586762075134 0.00668416489866728 -0.306525510428002 Nonsignificant None -- -- -- -- ko00260 Glycine, serine and threonine metabolism ko00270 Cysteine and methionine metabolism ko00290 Valine, leucine and isoleucine biosynthesis ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids Threonine/serine dehydratases E Amino acid transport and metabolism ; IPR001926 [Tryptophan synthase beta subunit-like PLP-dependent enzyme] -- -- A0A1Y7VLZ7 Phosphofurin acidic cluster sorting protein 2 Pacs2 66.2 54.9 57.1 77.9 72.9 84.7 0.756687898089172 0.0171468224582095 -0.402229722978224 Nonsignificant None -- -- -- -- -- PACS-1 cytosolic sorting protein U Intracellular trafficking, secretion, and vesicular transport ; IPR019381 [Phosphofurin acidic cluster sorting protein 1] -- -- Q9CZT5 Vasorin Vasn 307.1 313.5 244.3 250.9 249.7 230.7 1.18268836318884 0.125237004426004 0.242069975528162 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- FOG: Leucine rich repeat R General function prediction only ; IPR000742 [EGF-like domain] ; IPR001611[Leucine-rich repeat] ; IPR003961[Fibronectin type III] -- -- Q6DID3 SR-related and CTD-associated factor 8 Scaf8 140.8 104.7 92.6 72.5 82.6 94.5 1.35456730769231 0.13551225990378 0.437832082031129 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) RNA-binding protein 16 -- -- RNA polymerase II C-terminal domain-binding protein RA4, contains RPR and RRM domains AK RNA processing and modification ; Transcription ; IPR000504 [RNA recognition motif domain] ; IPR006903[RNA polymerase II-binding domain] -- -- Q3TGX0 Secretory carrier-associated membrane protein Scamp4 227.7 211.3 258.5 240.8 242.3 217.6 0.995433138290281 0.949981300460122 -0.00660367928968539 Nonsignificant None 2 Biological Process:protein transport (GO:0015031),Cellular Component:integral component of membrane (GO:0016021) secretory carrier-associated membrane protein -- -- Secretory carrier membrane protein U Intracellular trafficking, secretion, and vesicular transport ; IPR007273 [SCAMP] -- -- Q3TPT3 Synaptotagmin Syt1 501.1 466.8 532.2 541 530.1 590.2 0.902967555528803 0.111809499613859 -0.147253943635945 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) synaptotagmin-1 -- ko04721 Synaptic vesicle cycle Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR000008 [C2 domain] -- -- Q9CPY1 39S ribosomal protein L51, mitochondrial Mrpl51 84.5 84.9 103.3 86.1 81 87.8 1.06983130639466 0.414875988158126 0.0973833268930617 Nonsignificant None 1 Molecular Function:structural constituent of ribosome (GO:0003735) large subunit ribosomal protein L51 -- -- Uncharacterized conserved protein S Function unknown ; IPR019373 [Ribosomal protein L51, mitochondrial] -- -- F6QB26 Growth arrest-specific protein 7 Gas7 199.7 182.1 187.4 215.9 231.7 233.9 0.835216434336023 0.00827593451535867 -0.25977799516609 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) growth arrest-specific protein 7 -- -- Predicted proline-serine-threonine phosphatase-interacting protein (PSTPIP) D Cell cycle control, cell division, chromosome partitioning ; IPR001060 [FCH domain] ; IPR001202[WW domain] ; IPR001452[SH3 domain] -- -- S4R2K0 Peptide deformylase, mitochondrial Pdf 43.8 48.8 54.1 47.4 44 43.2 1.08989598811293 0.281205157482153 0.124190461063073 Nonsignificant None -- -- peptide deformylase 3.5.1.88 -- Peptide deformylase J Translation, ribosomal structure and biogenesis ; IPR023635 [Peptide deformylase] -- -- Q3USK4 Uncharacterized protein Sos1 177.5 177.4 155.2 150 145.4 164.3 1.10963671959974 0.146726434393119 0.150087434580139 Nonsignificant None 5 Molecular Function:DNA binding (GO:0003677),Molecular Function:guanyl-nucleotide exchange factor activity (GO:0005085),Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Biological Process:small GTPase mediated signal transduction (GO:0007264),Biological Process:regulation of Rho protein signal transduction (GO:0035023) son of sevenless -- ko01521 EGFR tyrosine kinase inhibitor resistance ko01522 Endocrine resistance ko04010 MAPK signaling pathway ko04012 ErbB signaling pathway ko04014 Ras signaling pathway ko04062 Chemokine signaling pathway ko04068 FoxO signaling pathway ko04072 Phospholipase D signaling pathway ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04540 Gap junction ko04630 Jak-STAT signaling pathway ko04650 Natural killer cell mediated cytotoxicity ko04660 T cell receptor signaling pathway ko04662 B cell receptor signaling pathway ko04664 Fc epsilon RI signaling pathway ko04722 Neurotrophin signaling pathway ko04810 Regulation of actin cytoskeleton ko04910 Insulin signaling pathway ko04912 GnRH signaling pathway ko04915 Estrogen signaling pathway ko04917 Prolactin signaling pathway ko04926 Relaxin signaling pathway ko05034 Alcoholism ko05160 Hepatitis C ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05206 MicroRNAs in cancer ko05211 Renal cell carcinoma ko05213 Endometrial cancer ko05214 Glioma ko05215 Prostate cancer ko05220 Chronic myeloid leukemia ko05221 Acute myeloid leukemia ko05223 Non-small cell lung cancer ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer ko05231 Choline metabolism in cancer Ras1 guanine nucleotide exchange factor T Signal transduction mechanisms ; IPR000219 [Dbl homology (DH) domain] ; IPR000651[Ras-like guanine nucleotide exchange factor, N-terminal] ; IPR001849[Pleckstrin homology domain] ; IPR001895[Ras guanine-nucleotide exchange factors catalytic domain] ; IPR007125[Histone H2A/H2B/H3] -- -- Q3U926 Uncharacterized protein Ptpmt1 244.1 225.8 226.4 228.6 241.8 229.8 0.994430162810625 0.867923601138154 -0.00805803836286583 Nonsignificant None 2 Biological Process:protein dephosphorylation (GO:0006470),Molecular Function:protein tyrosine/serine/threonine phosphatase activity (GO:0008138) -- -- -- Dual specificity phosphatase V Defense mechanisms ; IPR000340 [Dual specificity phosphatase, catalytic domain] -- -- A0A0B4J1L4 Obscurin-like protein 1 Obsl1 41.3 49.2 52.2 46.6 46.9 46.6 1.01855817273376 0.814791110730349 0.0265283790449454 Nonsignificant None -- -- obscurin-like protein 1 -- -- -- -- -- IPR013098 [Immunoglobulin I-set] -- -- A0A0G2JFA8 Immunoglobulin kappa variable 17-121 (Fragment) Igkv17-121 377.3 361.3 312.1 238.5 234.6 238.9 1.47570224719101 0.0283883762690743 0.561401657824532 Nonsignificant None -- -- pre-B lymphocyte gene -- -- -- -- -- IPR013106 [Immunoglobulin V-set domain] -- -- Q9D8I3 Glyoxalase domain-containing protein 5 Glod5 320.7 377.5 374.8 659.8 594.5 635.2 0.567875099232601 0.000510345563194666 -0.816354442503439 Significant down -- -- -- -- -- -- -- -- IPR004360 [Glyoxalase/fosfomycin resistance/dioxygenase domain] -- -- Q3U6Y6 Uncharacterized protein Cyth4 399.7 406.9 319 241.4 278 243.8 1.4748427672956 0.0167695979475702 0.560561157231021 Nonsignificant None 2 Molecular Function:ARF guanyl-nucleotide exchange factor activity (GO:0005086),Biological Process:regulation of ARF protein signal transduction (GO:0032012) cytohesin -- ko04072 Phospholipase D signaling pathway ko04144 Endocytosis Guanine nucleotide exchange factor Cytohesin, contains PH and Sec7 domains U Intracellular trafficking, secretion, and vesicular transport ; IPR000904 [Sec7 domain] ; IPR001849[Pleckstrin homology domain] -- -- Q6PGG6 Guanine nucleotide-binding protein-like 3-like protein Gnl3l 205.3 276.9 261.6 233.7 217.9 204.1 1.13436022571298 0.277606642922739 0.18187885308796 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) nuclear GTP-binding protein -- ko03008 Ribosome biogenesis in eukaryotes GTPase R General function prediction only ; IPR006073 [GTP binding domain] -- -- B7ZP10 Cyp2d12 protein Cyp2d12 50.4 48.5 44.8 82.6 88.3 70.5 0.595277547638774 0.00407368210119145 -0.748365614297685 Significant down 3 Molecular Function:iron ion binding (GO:0005506),Molecular Function:heme binding (GO:0020037),Biological Process:oxidation-reduction process (GO:0055114) cytochrome P450 family 2 subfamily D 1.14.14.1 ko00140 Steroid hormone biosynthesis ko04726 Serotonergic synapse Cytochrome P450 CYP2 subfamily Q Secondary metabolites biosynthesis, transport and catabolism ; IPR001128 [Cytochrome P450] -- -- Q9CR89 Endoplasmic reticulum-Golgi intermediate compartment protein 2 Ergic2 40.7 37.8 40.9 32 36.6 44 1.06039076376554 0.566818350403979 0.0845960091845753 Nonsignificant None -- -- endoplasmic reticulum-Golgi intermediate compartment protein 2 -- -- COPII vesicle protein U Intracellular trafficking, secretion, and vesicular transport ; IPR012936 [Endoplasmic reticulum vesicle transporter, C-terminal] -- -- Q9D8P4 39S ribosomal protein L17, mitochondrial Mrpl17 305.4 301.5 320.1 306.3 314.5 322.1 0.983137130130449 0.50649452953397 -0.0245354340070142 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L17 -- ko03010 Ribosome Mitochondrial/chloroplast ribosomal protein L17 J Translation, ribosomal structure and biogenesis ; IPR000456 [Ribosomal protein L17] -- -- Q3UQM7 Uncharacterized protein Slc7a5 67.4 75.1 74.2 72 72.5 76.9 0.97877145438121 0.6161087495607 -0.0309560686878787 Nonsignificant None 3 Biological Process:amino acid transmembrane transport (GO:0003333),Molecular Function:amino acid transmembrane transporter activity (GO:0015171),Cellular Component:membrane (GO:0016020) solute carrier family 7 (L-type amino acid transporter), member 5 -- ko04150 mTOR signaling pathway ko05230 Central carbon metabolism in cancer Amino acid transporters E Amino acid transport and metabolism ; IPR002293 [Amino acid/polyamine transporter I] -- -- F6RDM4 Glutaminase (Fragment) Gls 89.7 94.8 107.2 84.9 86.5 90.2 1.11506116207951 0.138245465393555 0.157122845400095 Nonsignificant None 2 Molecular Function:glutaminase activity (GO:0004359),Biological Process:glutamine metabolic process (GO:0006541) glutaminase 3.5.1.2 ko00220 Arginine biosynthesis ko00250 Alanine, aspartate and glutamate metabolism ko00471 D-Glutamine and D-glutamate metabolism ko01100 Metabolic pathways ko04724 Glutamatergic synapse ko04727 GABAergic synapse ko04964 Proximal tubule bicarbonate reclamation ko05206 MicroRNAs in cancer ko05230 Central carbon metabolism in cancer Glutaminase (contains ankyrin repeat) E Amino acid transport and metabolism ; IPR015868 [Glutaminase] -- -- Q8CII3 3-ketodihydrosphingosine reductase Kdsr 165.4 143.3 209.6 230 208.7 241.7 0.761757789535567 0.0679214867354477 -0.392595747278686 Nonsignificant None -- -- 3-dehydrosphinganine reductase 1.1.1.102 ko00600 Sphingolipid metabolism ko01100 Metabolic pathways Predicted 3-ketosphinganine reductase Q Secondary metabolites biosynthesis, transport and catabolism ; IPR002347 [Short-chain dehydrogenase/reductase SDR] -- -- Q8CHK3 Lysophospholipid acyltransferase 7 Mboat7 174.7 138.4 93.7 90 97.9 109.1 1.36969696969697 0.20302310859131 0.453856748169372 Nonsignificant None -- -- lysophospholipid acyltransferase 7 2.3.1.- ko00564 Glycerophospholipid metabolism Predicted membrane protein S Function unknown ; IPR004299 [Membrane bound O-acyl transferase, MBOAT] -- -- Q4VAC9 Pleckstrin homology domain-containing family G member 3 Plekhg3 31.9 33.7 27.5 23.4 14 15.5 1.75992438563327 0.0177546673782586 0.815513445444768 Significant up 2 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Biological Process:regulation of Rho protein signal transduction (GO:0035023) -- -- -- -- -- -- IPR000219 [Dbl homology (DH) domain] ; IPR001849[Pleckstrin homology domain] -- -- Q8BWJ3 Phosphorylase b kinase regulatory subunit alpha, liver isoform Phka2 55.4 60.6 52.2 53.5 57 64.2 0.962793360045793 0.615872052676799 -0.0547019026616152 Nonsignificant None -- -- phosphorylase kinase alpha/beta subunit -- ko04020 Calcium signaling pathway ko04910 Insulin signaling pathway ko04922 Glucagon signaling pathway Phosphorylase kinase G Carbohydrate transport and metabolism ; IPR011613 [Glycoside hydrolase family 15/Phosphorylase b kinase regulatory chain family] -- -- O89103 Complement component C1q receptor Cd93 463.6 424.8 380.5 357 353.1 359.5 1.18633133881825 0.108671360192758 0.246507006602991 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) CDW93 antigen -- -- -- -- -- IPR001304 [C-type lectin-like] ; IPR001881[EGF-like calcium-binding domain] ; IPR026823[Complement Clr-like EGF domain] -- -- A0A4U9FKB1 IgG3 Ighg3 334.8 390.8 347.3 320.6 296.1 304.2 1.16505592355305 0.0514834002962261 0.220399206979342 Nonsignificant None -- -- immunoglobulin lambda-like polypeptide 1 -- -- -- -- -- IPR003597 [Immunoglobulin C1-set] -- -- Q8C397 Uncharacterized protein Tmem201 86.9 98.9 123.4 109.1 94.4 94.2 1.03862949277796 0.761946407009069 0.0546810976868114 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR018617 [Ima1, N-terminal domain] ; IPR018861[Protein of unknown function DUF2448] -- -- Q3UYC0 Protein phosphatase 1H Ppm1h 246.5 222.7 241.5 243.2 274.2 265.7 0.90754692887243 0.109167485653651 -0.139955848692445 Nonsignificant None 1 Molecular Function:catalytic activity (GO:0003824) protein phosphatase 1H 3.1.3.16 -- Serine/threonine phosphatase T Signal transduction mechanisms ; IPR001932 [PPM-type phosphatase domain] -- -- Q9CVT6 Mitochondrial import inner membrane translocase subunit Tim21 (Fragment) Timm21 256.2 253 269.3 288 276 279.9 0.922502666192677 0.0234405432086827 -0.116375014069457 Nonsignificant None 2 Cellular Component:mitochondrial inner membrane presequence translocase complex (GO:0005744),Biological Process:protein import into mitochondrial matrix (GO:0030150) mitochondrial import inner membrane translocase subunit TIM21 -- -- Uncharacterized conserved protein S Function unknown ; IPR013261 [Mitochondrial import inner membrane translocase subunit Tim21] -- -- Q8VIK2 Mpv17-like protein 2 Mpv17l2 38.6 42.6 35.7 38.3 41.2 48.7 0.91185647425897 0.364854513563139 -0.133121332087085 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) protein Mpv17 -- ko04146 Peroxisome Peroxisomal membrane protein MPV17 and related proteins R General function prediction only ; IPR007248 [Mpv17/PMP22] -- -- Q9QYC7 Vitamin K-dependent gamma-carboxylase Ggcx 85.2 82.7 84.1 76.7 82.6 83.1 1.03960396039604 0.215818852301674 0.056034034914328 Nonsignificant None 2 Molecular Function:gamma-glutamyl carboxylase activity (GO:0008488),Biological Process:peptidyl-glutamic acid carboxylation (GO:0017187) vitamin K-dependent gamma-carboxylase 4.1.1.90 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis -- -- -- IPR007782 [Vitamin K-dependent gamma-carboxylase] -- -- Q9D948 Probable U3 small nucleolar RNA-associated protein 11 Utp11 205 195.1 150.8 157.3 172.2 154.9 1.13728323699422 0.27447994505092 0.185591597870762 Nonsignificant None 2 Biological Process:rRNA processing (GO:0006364),Cellular Component:small-subunit processome (GO:0032040) U3 small nucleolar RNA-associated protein 11 -- -- Uncharacterized conserved protein S Function unknown ; IPR007144 [Small-subunit processome, Utp11] -- -- A0A0R4J211 Rho guanine nucleotide exchange factor 25 Arhgef25 82.5 107.1 131.9 113.8 117.2 94.9 0.986498926050936 0.930758091392721 -0.0196106145232546 Nonsignificant None 2 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Biological Process:regulation of Rho protein signal transduction (GO:0035023) Rho guanine nucleotide exchange factor 25 -- -- Guanine nucleotide exchange factor for Rho and Rac GTPases T Signal transduction mechanisms ; IPR000219 [Dbl homology (DH) domain] -- -- J3QJW3 Calcium-dependent secretion activator 1 Cadps 26.6 19.7 33.2 48.2 49.3 34.1 0.604103343465046 0.0500231299621024 -0.727132723563524 Nonsignificant None -- -- calcium-dependent secretion activator -- -- Ca2+-dependent activator protein T Signal transduction mechanisms ; IPR001849 [Pleckstrin homology domain] ; IPR010439[Calcium-dependent secretion activator domain] -- -- Q9D8Y1 Transmembrane protein 126A Tmem126a 318.7 315.8 359.1 312.4 320.5 346.2 1.01480951894597 0.793741739119233 0.021208957103905 Nonsignificant None -- -- transmembrane protein 126A -- -- -- -- -- IPR009801 [Transmembrane protein 126] -- -- Q8CBE3 WD repeat-containing protein 37 Wdr37 176.3 166.5 135.5 79.4 86.5 99.3 1.80354449472097 0.00642327700516905 0.850835015873718 Significant up 1 Molecular Function:protein binding (GO:0005515) -- -- -- WD40 repeat-containing protein S Function unknown ; IPR001680 [WD40 repeat] -- -- A0A1B0GSM3 Arfaptin-2 Arfip2 209.3 185.7 218.7 259.5 245.5 225.9 0.839649746887399 0.0476085378321468 -0.252140450099083 Nonsignificant None 1 Molecular Function:protein domain specific binding (GO:0019904) arfaptin -- -- Arfaptin and related proteins T Signal transduction mechanisms ; IPR010504 [Arfaptin homology (AH) domain] -- -- D3Z5Y0 Endothelial cell-selective adhesion molecule (Fragment) Esam 66.9 68.3 86.5 78.8 74 82.5 0.942201444963876 0.540083262411428 -0.0858925503569904 Nonsignificant None -- -- endothelial cell adhesion molecule -- ko04514 Cell adhesion molecules (CAMs) ko04670 Leukocyte transendothelial migration -- -- -- IPR013106 [Immunoglobulin V-set domain] -- -- Q8VEG6 CCR4-NOT transcription complex subunit 6-like Cnot6l 242.6 267.7 280.5 265.6 265.5 250.9 1.01125319693095 0.821171690161614 0.0161442635344934 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) CCR4-NOT transcription complex subunit 6 3.1.13.4 ko03018 RNA degradation Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins K Transcription ; IPR001611 [Leucine-rich repeat] ; IPR005135[Endonuclease/exonuclease/phosphatase] -- -- Q8C0N2 Glycerol-3-phosphate acyltransferase 3 Gpat3 35.4 33 25.8 36.2 39.4 35.3 0.84941388638413 0.151071099098789 -0.235460400548927 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) glycerol-3-phosphate O-acyltransferase 3/4 2.3.1.15 ko00561 Glycerolipid metabolism ko00564 Glycerophospholipid metabolism ko01100 Metabolic pathways Predicted phosphate acyltransferase, contains PlsC domain I Lipid transport and metabolism ; IPR002123 [Phospholipid/glycerol acyltransferase] -- -- Q8BMQ8 Vacuolar fusion protein MON1 homolog B Mon1b 10.1 10.4 11.8 14.5 11.8 8.9 0.917613636363636 0.599945826460341 -0.124041263943372 Nonsignificant None -- -- vacuolar fusion protein MON1 -- Uncharacterized conserved protein Sand S Function unknown ; IPR004353 [Vacuolar fusion protein Mon1] -- -- A0A0A6YVR9 SURF1-like protein (Fragment) Surf1 91.5 78.7 108.3 85.3 69.7 86.8 1.15177832919768 0.295186539011439 0.20386308297827 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) surfeit locus 1 family protein -- -- Mitochondrial protein Surfeit 1/SURF1/SHY1, required for expression of cytochrome oxidase C Energy production and conversion ; IPR002994 [Surfeit locus 1/Shy1] -- -- P98191 Phosphatidate cytidylyltransferase 1 Cds1 20.4 18 15.4 15.1 21.7 18.5 0.972875226039783 0.844556813341287 -0.0396733076780828 Nonsignificant None -- -- phosphatidate cytidylyltransferase 2.7.7.41 ko00564 Glycerophospholipid metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system CDP-diacylglycerol synthase I Lipid transport and metabolism ; -- -- -- D6RG69 Coiled-coil domain-containing protein 167 Ccdc167 275.9 304 325.3 223.1 240.3 258.5 1.25391328438842 0.0254613751919743 0.326437580589277 Nonsignificant None -- -- -- -- -- -- -- -- IPR028194 [Coiled-coil domain-containing protein 167] -- -- Q9ERS5 Pleckstrin homology domain-containing family A member 2 Plekha2 232.4 207.8 180.5 164 202 205.8 1.08551941238195 0.462247084175774 0.118385525950068 Nonsignificant None -- -- -- -- -- -- -- -- IPR001849 [Pleckstrin homology domain] -- -- Q3U606 RNA helicase Dhx58 55.4 49.9 36.3 49 56.1 69.8 0.809605488850772 0.253808569001463 -0.304709023838655 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Molecular Function:ATP binding (GO:0005524),Molecular Function:hydrolase activity (GO:0016787) ATP-dependent RNA helicase DHX58 3.6.3.14 ko04622 RIG-I-like receptor signaling pathway DEAD-box like helicase R General function prediction only ; IPR001650 [Helicase, C-terminal] ; IPR006935[Helicase/UvrB, N-terminal] ; IPR021673[C-terminal domain of RIG-I] -- -- Q00899 Transcriptional repressor protein YY1 Yy1 1099 1056.1 939.9 820.4 779.6 879.5 1.24823553135713 0.0211087088380189 0.319890184088157 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) transcription factor YY -- -- FOG: Zn-finger R General function prediction only ; IPR007087 [Zinc finger, C2H2] -- zf-C2H2 Q9WTU0 Lysine-specific demethylase PHF2 Phf2 132.8 128.2 151.7 153.3 175.2 155.6 0.852509812022309 0.0759717797708542 -0.230211655853821 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) lysine-specific demethylase PHF2 1.14.11.- -- F-box protein JEMMA and related proteins with JmjC, PHD, F-box and LRR domains B Chromatin structure and dynamics ; IPR003347 [JmjC domain] ; IPR019787[Zinc finger, PHD-finger] -- -- Q5XJE5 RNA polymerase-associated protein LEO1 Leo1 291.9 298.8 312.4 278.4 288.3 270.1 1.07923040152964 0.0506545313528864 0.11000289416816 Nonsignificant None 3 Biological Process:transcription elongation from RNA polymerase II promoter (GO:0006368),Biological Process:histone modification (GO:0016570),Cellular Component:Cdc73/Paf1 complex (GO:0016593) RNA polymerase-associated protein LEO1 -- -- Uncharacterized conserved protein S Function unknown ; IPR007149 [Leo1-like protein] -- -- Q9CQV5 28S ribosomal protein S24, mitochondrial Mrps24 539.1 490.5 705 638.5 585.7 596.7 0.952605854247899 0.689334133439103 -0.070048680062752 Nonsignificant None 1 Cellular Component:mitochondrion (GO:0005739) small subunit ribosomal protein S24 -- -- -- -- -- IPR026146 [28S ribosomal protein S24, mitochondrial] -- -- Q8BKX6 Serine/threonine-protein kinase SMG1 Smg1 37.7 37.2 29.4 46.2 40.5 38.1 0.835737179487179 0.130860299404349 -0.258878776342483 Nonsignificant None 4 Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:protein binding (GO:0005515),Molecular Function:kinase activity (GO:0016301),Biological Process:phosphorylation (GO:0016310) serine/threonine-protein kinase SMG1 2.7.11.1 ko03015 mRNA surveillance pathway DNA-dependent protein kinase L Replication, recombination and repair ; IPR000403 [Phosphatidylinositol 3-/4-kinase, catalytic domain] ; IPR003152[FATC domain] ; IPR031559[Serine/threonine-protein kinase SMG1] -- -- D3Z079 Syntaxin-binding protein 5 Stxbp5 276.2 294.6 303.6 301.6 305.3 293.5 0.971123944913372 0.37967474361299 -0.0422726557822509 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) syntaxin-binding protein 5 -- -- Tomosyn and related SNARE-interacting proteins U Intracellular trafficking, secretion, and vesicular transport ; IPR001680 [WD40 repeat] ; IPR013577[Lethal giant larvae homologue 2] ; IPR013905[Lethal giant larvae (Lgl)-like, C-terminal domain] -- -- Q5SQF9 Polypeptide N-acetylgalactosaminyltransferase Galnt10 190.4 147 140.9 164.9 160.3 182 0.943020504731861 0.599649003901871 -0.0846389541531016 Nonsignificant None -- -- polypeptide N-acetylgalactosaminyltransferase 2.4.1.41 ko00512 Mucin type O-glycan biosynthesis ko01100 Metabolic pathways Polypeptide N-acetylgalactosaminyltransferase O Posttranslational modification, protein turnover, chaperones ; IPR000772 [Ricin B, lectin domain] ; IPR001173[Glycosyltransferase 2-like] -- -- P60487 Chronophin Pdxp 61.7 61.8 84.9 91 102.7 86.4 0.744019992859693 0.0586784764117477 -0.426586705795998 Nonsignificant None -- -- pyridoxal phosphatase 3.1.3.74 ko00750 Vitamin B6 metabolism ko01100 Metabolic pathways p-Nitrophenyl phosphatase P Inorganic ion transport and metabolism ; IPR006357 [HAD-superfamily hydrolase, subfamily IIA] -- -- Q9D1I6 39S ribosomal protein L14, mitochondrial Mrpl14 635.2 671.6 356.6 386.3 376.8 405.4 1.42353444587077 0.238550819649189 0.509477403010419 Nonsignificant None 3 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L14 -- ko03010 Ribosome Mitochondrial ribosomal protein L14 J Translation, ribosomal structure and biogenesis ; IPR000218 [Ribosomal protein L14P] -- -- Q9EP97 Sentrin-specific protease 3 Senp3 93.5 87.7 76.9 92.4 89.8 89.8 0.948897058823529 0.401432723401728 -0.0756765100437319 Nonsignificant None 2 Biological Process:proteolysis (GO:0006508),Molecular Function:cysteine-type peptidase activity (GO:0008234) sentrin-specific protease 3 3.4.22.68 -- Protease, Ulp1 family O Posttranslational modification, protein turnover, chaperones ; IPR003653 [Ulp1 protease family, C-terminal catalytic domain] -- -- O70579 Peroxisomal membrane protein PMP34 Slc25a17 151.5 166.1 147.8 154.3 162.3 149.1 0.999355808460382 0.988935805084923 -0.000929671414979638 Nonsignificant None -- -- solute carrier family 25 (peroxisomal adenine nucleotide transporter), member 17 -- ko04146 Peroxisome Predicted mitochondrial carrier protein C Energy production and conversion ; IPR018108 [Mitochondrial substrate/solute carrier] -- -- Q9CWW9 2410002F23Rik protein 2410002F23Rik 20.9 20.9 21.2 24.2 23.9 24.6 0.866574965612104 0.000138853241438504 -0.206603535532316 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q99MJ6 Na(+)/H(+) exchange regulatory cofactor NHE-RF4 Pdzd3 9.7 12.5 10.2 16.5 14.7 18.1 0.657200811359026 0.012538911989694 -0.605593833493287 Significant down 1 Molecular Function:protein binding (GO:0005515) -- -- -- FOG: PDZ domain S Function unknown ; IPR001478 [PDZ domain] -- -- A8C756 Thyroid adenoma-associated protein homolog Thada 355.1 334.8 337.1 325.6 320.5 329.3 1.05290137379537 0.0674471054535837 0.0743703041696899 Nonsignificant None -- -- -- -- -- Cell cycle-associated protein D Cell cycle control, cell division, chromosome partitioning ; IPR019442 [Domain of unknown function DUF2428, death-receptor-like] -- -- Q9D823 60S ribosomal protein L37 Rpl37 873.1 1350.1 1596.9 1421.2 1428.8 1082.3 0.971467080334664 0.884291066220938 -0.0417629862024305 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L37e -- ko03010 Ribosome 60S ribosomal protein L37 J Translation, ribosomal structure and biogenesis ; IPR001569 [Ribosomal protein L37e] -- -- Q6PD19 Armadillo-like helical domain-containing protein 3 Armh3 32.9 29.6 65.1 44.2 49.1 42.8 0.937545922116091 0.81726059011958 -0.0930387377391253 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR013636 [Domain of unknown function DUF1741] -- -- V9GWU2 Transcription factor 12 (Fragment) Tcf12 368.2 383.1 306.6 262.1 282.3 292.2 1.2645230695673 0.0421104738237416 0.338593357322809 Nonsignificant None 1 Molecular Function:protein dimerization activity (GO:0046983) transcription factor 4/12 -- -- Helix loop helix transcription factor K Transcription ; IPR011598 [Myc-type, basic helix-loop-helix (bHLH) domain] -- bHLH Q8K425 Resistin-like molecule beta Retnlb 258.1 349.5 485.5 93.2 70.3 65.2 4.77962396152164 0.0466438174961454 2.25689711816661 Significant up 2 Molecular Function:hormone activity (GO:0005179),Cellular Component:extracellular region (GO:0005576) -- -- -- -- -- -- IPR009714 [Resistin] -- -- A0A0R4J131 Biotinidase Btd 208.2 168.4 162.9 245.9 258 253.7 0.712117212249208 0.00779455070315318 -0.489813371093006 Nonsignificant None 1 Biological Process:nitrogen compound metabolic process (GO:0006807) biotinidase 3.5.1.12 ko00780 Biotin metabolism ko01100 Metabolic pathways ko04977 Vitamin digestion and absorption Carbon-nitrogen hydrolase E Amino acid transport and metabolism ; IPR003010 [Carbon-nitrogen hydrolase] -- -- Q9JJ78 Lymphokine-activated killer T-cell-originated protein kinase Pbk 306.6 321.7 339 293.1 319.8 284.1 1.0783723522854 0.17498001139702 0.108855413750298 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) PDZ-binding kinase 2.7.12.2 -- Tyrosine kinase specific for activated (GTP-bound) p21cdc42Hs T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- D3YZL3 Zinc finger protein 800 (Fragment) Zfp800 11.6 14.3 10.4 10.8 14 9.7 1.05217391304348 0.746220804854586 0.0733731863302192 Nonsignificant None -- -- -- -- -- FOG: Zn-finger R General function prediction only ; -- -- -- Q9QZU5 Keratin-associated protein 15-1 Krtap15-1 19.5 19.2 20.9 26.3 16.4 18.1 0.980263157894737 0.903587689544149 -0.0287589929814238 Nonsignificant None -- -- -- -- -- -- -- -- IPR007951 [Keratin-associated protein, PMG type] -- -- Q99LJ0 CTTNBP2 N-terminal-like protein Cttnbp2nl 383.5 369.5 384.9 386.5 395.4 377.7 0.981286650569162 0.365364644017183 -0.0272534610460032 Nonsignificant None -- -- -- -- -- Predicted coiled-coil protein S Function unknown ; IPR019131 [Cortactin-binding protein-2, N-terminal] -- -- Q8C3J5 Dedicator of cytokinesis protein 2 Dock2 86.1 87.5 73.4 49 66.2 65.9 1.36388735505246 0.0386311168486699 0.447724495521872 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) dedicator of cytokinesis protein 2 -- ko04062 Chemokine signaling pathway ko04666 Fc gamma R-mediated phagocytosis Signaling protein DOCK180 T Signal transduction mechanisms ; IPR001452 [SH3 domain] ; IPR010703[Dedicator of cytokinesis, C-terminal] ; IPR027007[DHR-1 domain] ; IPR032376[Dedicator of cytokinesis, N-terminal domain] -- -- Q3TQD9 Uncharacterized protein (Fragment) Sardh 405.3 548.5 467.6 345.2 332.9 305.1 1.44568755085435 0.027590418065534 0.531755783588726 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) sarcosine dehydrogenase 1.5.8.3 ko00260 Glycine, serine and threonine metabolism ko01100 Metabolic pathways Dimethylglycine dehydrogenase precursor E Amino acid transport and metabolism ; IPR006076 [FAD dependent oxidoreductase] ; IPR006222[Glycine cleavage T-protein-like, N-terminal] ; IPR013977[Glycine cleavage T-protein, C-terminal barrel domain] ; IPR032503[FAD dependent oxidoreductase, central domain] -- -- S4R225 WD repeat-containing protein 13 Wdr13 216.5 207.5 205.2 219.2 221.5 217.8 0.955504935459377 0.0538999053634905 -0.0656647697281901 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- WD40 repeat-containing protein R General function prediction only ; IPR001680 [WD40 repeat] -- -- Q8C0L9 Glycerophosphocholine phosphodiesterase GPCPD1 Gpcpd1 148.1 145.5 142.9 152.6 151.8 154.3 0.951602354480052 0.011466520327005 -0.0715692535651586 Nonsignificant None 3 Biological Process:lipid metabolic process (GO:0006629),Molecular Function:phosphoric diester hydrolase activity (GO:0008081),Molecular Function:starch binding (GO:2001070) glycerophosphocholine phosphodiesterase GPCPD1 3.1.4.2 ko00564 Glycerophospholipid metabolism ko05231 Choline metabolism in cancer Predicted starch-binding protein R General function prediction only ; IPR002044 [Carbohydrate binding module family 20] ; IPR030395[Glycerophosphodiester phosphodiesterase domain] -- -- A0A140LHN0 Protein YIF1 (Fragment) Yif1b 263.8 327.3 381.6 340.3 356.4 292.5 0.98331985442782 0.89486997991921 -0.0242673219247291 Nonsignificant None -- -- protein transport protein YIF1 -- -- Predicted membrane protein S Function unknown ; IPR005578 [Yif1 family] -- -- Q920Q8 Influenza virus NS1A-binding protein homolog Ivns1abp 538.8 528.4 560.5 497.6 527.9 502.5 1.06524869109948 0.0672121531770618 0.0911902788379302 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) influenza virus NS1A-binding protein -- ko05164 Influenza A Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes TR Signal transduction mechanisms ; General function prediction only ; IPR000210 [BTB/POZ domain] ; IPR006652[Kelch repeat type 1] ; IPR011705[BTB/Kelch-associated] -- ZBTB A0JNY4 Rasip1 protein Rasip1 49.8 57.1 46.4 43.8 49.3 49.5 1.0750350631136 0.385876414289418 0.104383715214889 Nonsignificant None -- -- -- -- -- Myosin class V heavy chain Z Cytoskeleton ; IPR002710 [Dilute domain] -- -- P63239 Neuroendocrine convertase 1 Pcsk1 165.5 170.5 217.6 264.6 251.9 277.9 0.696878147029204 0.0116305855014498 -0.521021679891649 Nonsignificant None 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) proprotein convertase subtilisin/kexin type 1 3.4.21.93 -- Subtilisin-like proprotein convertase O Posttranslational modification, protein turnover, chaperones ; IPR000209 [Peptidase S8/S53 domain] ; IPR002884[Proprotein convertase, P] ; IPR022005[Prohormone convertase enzyme] ; IPR032815[Peptidase S8, pro-domain] -- -- Q91WD4 UPF0415 protein C7orf25 homolog 37.1 35.1 45.9 43.6 44.7 53.4 0.833450952717008 0.158178625535743 -0.262830793520861 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR010733 [Protein of unknown function DUF1308] -- -- Q5SV80 Unconventional myosin-XIX Myo19 77.6 81 81.1 73.3 80 78.3 1.03497409326425 0.308578176877866 0.0495946556598962 Nonsignificant None 4 Molecular Function:motor activity (GO:0003774),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Cellular Component:myosin complex (GO:0016459) -- -- -- Myosin class V heavy chain Z Cytoskeleton ; IPR000048 [IQ motif, EF-hand binding site] ; IPR001609[Myosin head, motor domain] -- -- E9Q2Y3 NF-kappa-B essential modulator Ikbkg 204.8 212.3 214.3 220.4 214.9 189.7 1.01024 0.8396652786626 0.0146980708761734 Nonsignificant None -- -- inhibitor of nuclear factor kappa-B kinase subunit gamma -- ko01523 Antifolate resistance ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04062 Chemokine signaling pathway ko04064 NF-kappa B signaling pathway ko04151 PI3K-Akt signaling pathway ko04210 Apoptosis ko04380 Osteoclast differentiation ko04620 Toll-like receptor signaling pathway ko04621 NOD-like receptor signaling pathway ko04622 RIG-I-like receptor signaling pathway ko04623 Cytosolic DNA-sensing pathway ko04657 IL-17 signaling pathway ko04658 Th1 and Th2 cell differentiation ko04659 Th17 cell differentiation ko04660 T cell receptor signaling pathway ko04662 B cell receptor signaling pathway ko04668 TNF signaling pathway ko04920 Adipocytokine signaling pathway ko05142 Chagas disease (American trypanosomiasis) ko05145 Toxoplasmosis ko05160 Hepatitis C ko05161 Hepatitis B ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05212 Pancreatic cancer ko05215 Prostate cancer ko05220 Chronic myeloid leukemia ko05221 Acute myeloid leukemia ko05222 Small cell lung cancer ko05340 Primary immunodeficiency ko05418 Fluid shear stress and atherosclerosis -- -- -- IPR021063 [NF-kappa-B essential modulator NEMO, N-terminal] ; IPR032419[NF-kappa-B essential modulator NEMO, CC2-LZ domain] -- -- Q4PJX1 Protein odr-4 homolog Odr4 650.9 653.8 696.5 780.3 784.4 784.8 0.851755692700575 0.0150472308854245 -0.231488410295775 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR029454 [ODR-4-like] -- -- A0A1Y7VK55 Nuclear factor 1 Nfic 135.7 181.5 166.5 154.1 182.7 165 0.963929852530889 0.722794250112909 -0.0529999329633099 Nonsignificant None 3 Cellular Component:intracellular (GO:0005622),Cellular Component:nucleus (GO:0005634),Biological Process:DNA replication (GO:0006260) nuclear factor I/C -- -- Nuclear factor I K Transcription ; IPR000647 [CTF transcription factor/nuclear factor 1] ; IPR003619[MAD homology 1, Dwarfin-type] ; IPR019548[CTF transcription factor/nuclear factor 1, N-terminal] -- CTF/NFI Q8K2P1 Leucine rich adaptor protein 1-like Lurap1l 158.8 148.5 165.4 180.7 185.7 203.9 0.828862002454848 0.0193498618794176 -0.270796168011059 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q3UXZ9 Lysine-specific demethylase 5A Kdm5a 15.5 13.5 19.5 12 17.5 15.1 1.08744394618834 0.613382504361792 0.120941037154185 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Molecular Function:protein binding (GO:0005515),Biological Process:oxidation-reduction process (GO:0055114) histone demethylase JARID1 1.14.11.- -- DNA-binding protein jumonji/RBP2/SMCY, contains JmjC domain R General function prediction only ; IPR001606 [ARID DNA-binding domain] ; IPR003347[JmjC domain] ; IPR003349[JmjN domain] ; IPR004198[Zinc finger, C5HC2-type] ; IPR013637[Lysine-specific demethylase-like domain] ; IPR019787[Zinc finger, PHD-finger] -- ARID Q9CUE2 Zpr1 domain-containing protein (Fragment) Zpr1 338.8 370.1 380.5 357 392.3 334.5 1.00516700498247 0.933367168604651 0.00743522005441453 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) zinc finger protein -- -- C4-type Zn-finger protein R General function prediction only ; IPR004457 [Zinc finger, ZPR1-type] -- -- A2AQ17 Complex I intermediate-associated protein 30, mitochondrial Ndufaf1 615.6 581.3 642.6 633.8 686.3 673.8 0.922563819649932 0.0963895271836465 -0.116279379803456 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR013857 [NADH:ubiquinone oxidoreductase intermediate-associated protein 30] -- -- D3Z512 Deoxyribonuclease II Dnase2a 54.1 48.7 42 42.5 46.9 51.4 1.02840909090909 0.774083126104088 0.0404142684459083 Nonsignificant None 2 Molecular Function:deoxyribonuclease II activity (GO:0004531),Biological Process:DNA metabolic process (GO:0006259) deoxyribonuclease II 3.1.22.1 ko04142 Lysosome Deoxyribonuclease II L Replication, recombination and repair ; IPR004947 [Deoxyribonuclease II] -- -- Q9QWT9 Kinesin-like protein KIFC1 Kifc1 31.9 40.8 40.9 44 36.1 40.2 0.944305901911887 0.584070171149524 -0.0826738076713945 Nonsignificant None 4 Molecular Function:microtubule motor activity (GO:0003777),Molecular Function:ATP binding (GO:0005524),Biological Process:microtubule-based movement (GO:0007018),Molecular Function:microtubule binding (GO:0008017) kinesin family member C1 -- -- Kinesin (KAR3 subfamily) Z Cytoskeleton ; IPR001752 [Kinesin motor domain] -- -- D3Z7B5 Protein CIP2A Cip2a 172.8 157.6 215.7 165.7 165.4 156 1.12112502566208 0.328441713635252 0.164947173633816 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- F6ZMT3 Target of EGR1 protein 1 (Fragment) Toe1 102.5 100.2 96.4 98.1 102.3 110.7 0.961427193828351 0.385434345731256 -0.0567504844150297 Nonsignificant None 2 Biological Process:nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289),Molecular Function:poly(A)-specific ribonuclease activity (GO:0004535) target of EGR1 protein 1 -- -- Poly(A)-specific exoribonuclease PARN L Replication, recombination and repair ; IPR006941 [Ribonuclease CAF1] -- -- Q4FJW2 Drap1 protein Drap1 93.5 99.7 123.4 136.6 127.5 111.1 0.843816631130064 0.172508666212672 -0.244998572378195 Nonsignificant None -- -- Dr1-associated corepressor -- -- Class 2 transcription repressor NC2, alpha subunit (DRAP1) K Transcription ; IPR003958 [Transcription factor CBF/NF-Y/archaeal histone domain] -- NF-YC Q8BTZ5 Ankyrin repeat domain-containing protein 46 Ankrd46 150.1 154.3 169.2 190.3 189.5 176.8 0.850880344951491 0.0189233928285142 -0.232971827702658 Nonsignificant None -- -- -- -- -- Ankyrin repeat protein R General function prediction only ; IPR020683 [Ankyrin repeat-containing domain] -- -- Q80ZM5 H1 histone family, member X H1f10 258.5 276.8 330 271.9 254.7 302.3 1.04391362046085 0.659802613559597 0.0620023397923867 Nonsignificant None 4 Cellular Component:nucleosome (GO:0000786),Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634),Biological Process:nucleosome assembly (GO:0006334) histone H1/5 -- -- Histone H1 B Chromatin structure and dynamics ; IPR005818 [Linker histone H1/H5, domain H15] -- -- Q9JMG7 Hepatoma-derived growth factor-related protein 3 Hdgfl3 310.1 295.8 743.8 377.5 429.5 430.1 1.09101931937596 0.822959306995745 0.125676648610297 Nonsignificant None -- -- -- -- -- Transcription coactivator K Transcription ; IPR000313 [PWWP domain] -- -- A0A0A0MQE5 Calmodulin-regulated spectrin-associated protein 1 Camsap1 43.9 39.5 31.3 30.5 32.4 21.4 1.36061684460261 0.113441461273342 0.444260855073743 Nonsignificant None 4 Molecular Function:calmodulin binding (GO:0005516),Molecular Function:microtubule binding (GO:0008017),Molecular Function:spectrin binding (GO:0030507),Biological Process:neuron projection development (GO:0031175) calmodulin-regulated spectrin-associated protein -- -- Uncharacterized CH domain protein Z Cytoskeleton ; IPR014797 [CKK domain] ; IPR022613[Calmodulin-regulated spectrin-associated protein, CH domain] ; IPR031372[CAMSAP, spectrin and Ca2+/calmodulin-binding region] -- -- P70459 ETS domain-containing transcription factor ERF Erf 312.1 299.1 291.2 257.5 281.7 278.1 1.10412333292549 0.042963301434692 0.1429013332229 Nonsignificant None 1 Molecular Function:sequence-specific DNA binding (GO:0043565) ETS domain-containing transcription factor ERF -- -- Predicted transcription factor K Transcription ; IPR000418 [Ets domain] -- ETS A0A571BF54 Voltage-gated potassium channel subunit beta-1 Kcnab2 54.6 52.5 44.8 48.8 51.3 50.2 1.01064537591484 0.870335246744684 0.0152768605857189 Nonsignificant None -- -- potassium voltage-gated channel Shaker-related subfamily A, beta member 2 -- -- Voltage-gated shaker-like K+ channel, subunit beta/KCNAB C Energy production and conversion ; IPR023210 [NADP-dependent oxidoreductase domain] -- -- Q3UR97 Sorting nexin-21 Snx21 44.1 37.2 31.3 37.5 36.8 36.5 1.01624548736462 0.886236118902917 0.0232489460310413 Nonsignificant None 1 Molecular Function:phosphatidylinositol binding (GO:0035091) sorting nexin-21 -- -- Intermediate filament-like protein, sorting nexins, and related proteins containing PX (PhoX) domain(s) ZUD Cytoskeleton ; Intracellular trafficking, secretion, and vesicular transport ; Cell cycle control, cell division, chromosome partitioning ; IPR001683 [Phox homologous domain] -- -- Q8VD26 Transmembrane protein 143 Tmem143 88.1 85.4 76.9 108.9 92 109.4 0.806961005478569 0.0396653234560526 -0.309429134596101 Nonsignificant None -- -- -- -- -- -- -- -- IPR022227 [Protein of unknown function DUF3754] -- -- Q9R060 Cytosolic Fe-S cluster assembly factor NUBP1 Nubp1 695.2 702.2 672.3 643.6 661.1 604.1 1.08429379715004 0.0485862337646483 0.116755718188371 Nonsignificant None -- -- -- -- -- Predicted ATPase, nucleotide-binding D Cell cycle control, cell division, chromosome partitioning ; IPR033756 [Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35] -- -- A0JP41 Daf2 protein Cd55b 232 193.2 217.9 229.4 256.3 252.8 0.8708192281652 0.0877132089384352 -0.199554831513384 Nonsignificant None -- -- decay accelerating factor -- ko04610 Complement and coagulation cascades ko04640 Hematopoietic cell lineage ko05416 Viral myocarditis -- -- -- IPR000436 [Sushi/SCR/CCP domain] -- -- O35516 Neurogenic locus notch homolog protein 2 Notch2 149.1 152.8 134.6 141.7 127.9 135.1 1.07857672349889 0.195903315194388 0.109128804847379 Nonsignificant None 6 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:protein binding (GO:0005515),Biological Process:Notch signaling pathway (GO:0007219),Biological Process:multicellular organism development (GO:0007275),Cellular Component:integral component of membrane (GO:0016021),Biological Process:cell differentiation (GO:0030154) Notch 2 -- ko01522 Endocrine resistance ko04330 Notch signaling pathway ko04658 Th1 and Th2 cell differentiation ko04919 Thyroid hormone signaling pathway ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05206 MicroRNAs in cancer ko05224 Breast cancer Fibrillins and related proteins containing Ca2+-binding EGF-like domains T Signal transduction mechanisms ; IPR000742 [EGF-like domain] ; IPR000800[Notch domain] ; IPR001881[EGF-like calcium-binding domain] ; IPR010660[Notch, NOD domain] ; IPR011656[Notch, NODP domain] ; IPR013032[EGF-like, conserved site] ; IPR020683[Ankyrin repeat-containing domain] ; IPR024600[Domain of unknown function DUF3454, notch] -- -- Q99N91 39S ribosomal protein L34, mitochondrial Mrpl34 304 290.5 296.7 327.3 336 308.7 0.916872427983539 0.0395395872106387 -0.125207081153112 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L34 -- ko03010 Ribosome Mitochondrial ribosomal protein L34 J Translation, ribosomal structure and biogenesis ; IPR000271 [Ribosomal protein L34] -- -- A8Y5G7 DNA polymerase delta subunit 2 (Fragment) Pold2 61.1 64.9 63.5 68.2 58.7 61.1 1.00797872340426 0.87814047763825 0.0114651864934545 Nonsignificant None -- -- DNA polymerase delta subunit 2 -- ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways ko03030 DNA replication ko03410 Base excision repair ko03420 Nucleotide excision repair ko03430 Mismatch repair ko03440 Homologous recombination ko05166 HTLV-I infection DNA polymerase delta, regulatory subunit 55 L Replication, recombination and repair ; -- -- -- Q8CFX3 Protocadherin 1 Pcdh1 316.8 289 323.9 287.4 269.9 272.1 1.12093079334459 0.0493571780312932 0.16469720840141 Nonsignificant None 3 Molecular Function:calcium ion binding (GO:0005509),Biological Process:homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156),Cellular Component:membrane (GO:0016020) protocadherin delta 1 -- -- -- -- -- IPR002126 [Cadherin] ; IPR013164[Cadherin, N-terminal] ; IPR013585[Protocadherin] -- -- E9PUD0 Zinc finger Ran-binding domain-containing protein 2 Zranb2 330.6 338 259.4 257.7 234.4 261.1 1.23207647371216 0.0921436182062995 0.301091805400706 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) -- -- -- Conserved Zn-finger protein R General function prediction only ; IPR001876 [Zinc finger, RanBP2-type] -- -- Q62311 Transcription initiation factor TFIID subunit 6 Taf6 58.8 53.4 45.1 52.5 53 57.3 0.966216216216216 0.689487506687376 -0.0495820288505605 Nonsignificant None 2 Cellular Component:nucleus (GO:0005634),Biological Process:regulation of sequence-specific DNA binding transcription factor activity (GO:0051090) transcription initiation factor TFIID subunit 6 -- ko03022 Basal transcription factors ko05168 Herpes simplex infection Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) K Transcription ; IPR004823 [TATA box binding protein associated factor (TAF)] ; IPR011442[TAF6, C-terminal HEAT repeat domain] -- -- Q01237 3-hydroxy-3-methylglutaryl-coenzyme A reductase Hmgcr 141.4 154.5 233.5 165.5 158.6 203.9 1.00265151515152 0.98907402729066 0.0038202652495828 Nonsignificant None 4 Molecular Function:hydroxymethylglutaryl-CoA reductase (NADPH) activity (GO:0004420),Biological Process:coenzyme A metabolic process (GO:0015936),Molecular Function:coenzyme binding (GO:0050662),Biological Process:oxidation-reduction process (GO:0055114) hydroxymethylglutaryl-CoA reductase (NADPH) 1.1.1.34 ko00900 Terpenoid backbone biosynthesis ko01100 Metabolic pathways ko04152 AMPK signaling pathway ko04976 Bile secretion 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase I Lipid transport and metabolism ; IPR000731 [Sterol-sensing domain] ; IPR002202[Hydroxymethylglutaryl-CoA reductase, class I/II] -- -- H2ELL3 Alpha L integrin (Fragment) Itgal 301.9 314 313.8 254.6 243.1 259.8 1.22732673267327 0.000830750246342989 0.295519367059696 Nonsignificant None -- -- integrin alpha L -- ko04015 Rap1 signaling pathway ko04514 Cell adhesion molecules (CAMs) ko04650 Natural killer cell mediated cytotoxicity ko04670 Leukocyte transendothelial migration ko04810 Regulation of actin cytoskeleton ko05144 Malaria ko05150 Staphylococcus aureus infection ko05166 HTLV-I infection ko05169 Epstein-Barr virus infection ko05323 Rheumatoid arthritis ko05416 Viral myocarditis Vitronectin receptor, alpha subunit W Extracellular structures ; IPR002035 [von Willebrand factor, type A] ; IPR013517[FG-GAP repeat] ; IPR013649[Integrin alpha-2] ; IPR018184[Integrin alpha chain, C-terminal cytoplasmic region, conserved site] -- -- O09005 Sphingolipid delta(4)-desaturase DES1 Degs1 97.5 96.6 120.1 86.7 100.5 91.9 1.12576137585095 0.248828078792221 0.170901056228129 Nonsignificant None 1 Biological Process:lipid metabolic process (GO:0006629) -- -- ko00600 Sphingolipid metabolism ko01100 Metabolic pathways ko04071 Sphingolipid signaling pathway Fatty acid desaturase I Lipid transport and metabolism ; IPR005804 [Fatty acid desaturase domain] ; IPR013866[Sphingolipid delta4-desaturase, N-terminal] -- -- P59808 SAM and SH3 domain-containing protein 1 Sash1 108.5 95.6 97.3 116.8 101 106.1 0.930534115467737 0.290878392596641 -0.103869051197363 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Uncharacterized SAM domain protein R General function prediction only ; IPR001660 [Sterile alpha motif domain] ; IPR011511[Variant SH3 domain] ; IPR021090[SAM/SH3 domain-containing] -- -- Q6P5B0 RRP12-like protein Rrp12 623.9 603.3 544 523.3 520.7 506.9 1.14204655361403 0.039975447358438 0.191621460945232 Nonsignificant None -- -- ribosomal RNA-processing protein 12 -- -- Uncharacterized conserved protein S Function unknown ; IPR012978 [Uncharacterised domain NUC173] -- -- Q9QXG2 Rab proteins geranylgeranyltransferase component A 1 Chm 74 72.5 105.2 95.2 106.9 74.7 0.909320809248555 0.587860228900388 -0.137138726475745 Nonsignificant None 2 Molecular Function:GDP-dissociation inhibitor activity (GO:0005092),Biological Process:small GTPase mediated signal transduction (GO:0007264) -- -- -- GDP dissociation inhibitor TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR018203 [GDP dissociation inhibitor] -- -- B7ZWE5 B-cell leukemia/lymphoma 10 Bcl10 66.6 57.6 63.2 61.1 57.4 70.3 0.992584745762712 0.924836278843787 -0.0107378117026543 Nonsignificant None 1 Biological Process:regulation of apoptotic process (GO:0042981) B-cell CLL/lymphoma 10 -- ko04064 NF-kappa B signaling pathway ko04660 T cell receptor signaling pathway ko04662 B cell receptor signaling pathway ko05152 Tuberculosis -- -- -- IPR001315 [CARD domain] -- -- Q9CPW3 39S ribosomal protein L54, mitochondrial Mrpl54 308.8 288.3 370.9 318.1 348.5 302.7 0.998658825956876 0.98849343767628 -0.0019362038245631 Nonsignificant None -- -- large subunit ribosomal protein L54 -- -- Mitochondrial/chloroplast ribosomal protein L54/L37 J Translation, ribosomal structure and biogenesis ; IPR013870 [Ribosomal protein L37, mitochondrial] -- -- Q9DB40 Mediator of RNA polymerase II transcription subunit 27 Med27 238.5 234.1 183.5 184.6 213.1 193.6 1.10958904109589 0.331162050170569 0.150025444004607 Nonsignificant None -- -- mediator of RNA polymerase II transcription subunit 27 -- ko04919 Thyroid hormone signaling pathway -- -- -- IPR021627 [Mediator complex, subunit Med27] -- -- P21956 Lactadherin Mfge8 286 254.2 220.1 253.4 291.1 294.2 0.90652199833075 0.321317069937882 -0.141586064992278 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) lactadherin -- -- -- -- -- IPR000421 [Coagulation factor 5/8 C-terminal domain] ; IPR000742[EGF-like domain] -- -- Q3UG37 Uncharacterized protein (Fragment) Hdac6 155 139.6 129.1 147.1 141.5 155 0.955139765554553 0.477768857892952 -0.06621623679782 Nonsignificant None -- -- histone deacetylase 6 3.5.1.98 ko05034 Alcoholism ko05165 Human papillomavirus infection ko05203 Viral carcinogenesis Histone deacetylase complex, catalytic component HDA1 B Chromatin structure and dynamics ; IPR023801 [Histone deacetylase domain] -- -- Q1RME4 CAR-like soluble protein Gm1123 166.7 161.5 170.3 237.9 236.8 251.4 0.686544553091861 0.00014295483261229 -0.542574748238168 Nonsignificant None -- -- -- -- -- -- -- -- IPR013106 [Immunoglobulin V-set domain] -- -- Q0P635 Receptor protein-tyrosine kinase Csf1r 108.7 121.4 118.1 114 112.6 111.8 1.0289598108747 0.444884547689696 0.0411866345311513 Nonsignificant None 2 Molecular Function:protein kinase activity (GO:0004672),Biological Process:protein phosphorylation (GO:0006468) macrophage colony-stimulating factor 1 receptor 2.7.10.1 ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04060 Cytokine-cytokine receptor interaction ko04151 PI3K-Akt signaling pathway ko04380 Osteoclast differentiation ko04640 Hematopoietic cell lineage ko05200 Pathways in cancer ko05202 Transcriptional misregulation in cancer ko05221 Acute myeloid leukemia Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases T Signal transduction mechanisms ; IPR001245 [Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR013151[Immunoglobulin] -- -- Q9D115 Zinc finger protein 706 Znf706 406 350.3 352.8 412.3 340.8 411.5 0.952344152498712 0.569109519567718 -0.0704450745264207 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR007513 [Uncharacterised protein family SERF] -- -- E9PZM4 Chromodomain-helicase-DNA-binding protein 2 Chd2 133.2 125.4 121.4 153.9 160.1 152.5 0.814576634512326 0.0023124469279492 -0.295877662520811 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) chromodomain-helicase-DNA-binding protein 2 3.6.4.12 -- Chromodomain-helicase DNA-binding protein K Transcription ; IPR000330 [SNF2-related, N-terminal domain] ; IPR001650[Helicase, C-terminal] ; IPR023780[Chromo domain] ; IPR025260[Domain of unknown function DUF4208] -- -- D3Z4S3 Putative peptidyl-tRNA hydrolase PTRHD1 Ptrhd1 78.5 72.1 87.1 108.5 106.7 97 0.761370916079436 0.0115562246549942 -0.393328634035474 Nonsignificant None 1 Molecular Function:aminoacyl-tRNA hydrolase activity (GO:0004045) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR002833 [Peptidyl-tRNA hydrolase, PTH2] -- -- Q9DBS6 Phosphodiesterase Pde1b 115 102.4 108.8 116.8 130.1 123.7 0.880194279546681 0.048911571330047 -0.184106099315381 Nonsignificant None 2 Molecular Function:3',5'-cyclic-nucleotide phosphodiesterase activity (GO:0004114),Biological Process:signal transduction (GO:0007165) calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 3.1.4.17 ko00230 Purine metabolism ko04020 Calcium signaling pathway ko04740 Olfactory transduction ko04742 Taste transduction ko04924 Renin secretion ko05032 Morphine addiction Cyclic GMP phosphodiesterase T Signal transduction mechanisms ; IPR002073 [3'5'-cyclic nucleotide phosphodiesterase, catalytic domain] ; IPR013706[3'5'-cyclic nucleotide phosphodiesterase N-terminal] -- -- P49282 Natural resistance-associated macrophage protein 2 Slc11a2 9.3 8.1 17.3 15.1 13.8 16.8 0.759299781181619 0.290834264101282 -0.397258502479809 Nonsignificant None 3 Molecular Function:transporter activity (GO:0005215),Biological Process:transport (GO:0006810),Cellular Component:membrane (GO:0016020) natural resistance-associated macrophage protein 2 -- ko04142 Lysosome ko04216 Ferroptosis ko04978 Mineral absorption Mn2+ and Fe2+ transporters of the NRAMP family P Inorganic ion transport and metabolism ; IPR001046 [NRAMP family] -- -- O89094 Caspase-14 Casp14 97.9 80.4 71.7 154.3 185.7 146.6 0.51376900945335 0.00517654423663638 -0.960808225388979 Significant down -- -- caspase 14 3.4.22.- -- Caspase, apoptotic cysteine protease D Cell cycle control, cell division, chromosome partitioning ; -- -- -- P41230 Lysine-specific demethylase 5C Kdm5c 148.6 155.8 80.8 86.7 89.4 98.8 1.40123681338669 0.26220014157449 0.486700796330506 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Molecular Function:protein binding (GO:0005515),Biological Process:oxidation-reduction process (GO:0055114) histone demethylase JARID1 1.14.11.- -- DNA-binding protein jumonji/RBP2/SMCY, contains JmjC domain R General function prediction only ; IPR001606 [ARID DNA-binding domain] ; IPR003347[JmjC domain] ; IPR003349[JmjN domain] ; IPR004198[Zinc finger, C5HC2-type] ; IPR013637[Lysine-specific demethylase-like domain] ; IPR019787[Zinc finger, PHD-finger] -- ARID F6VQ19 Leucine-rich repeat and calponin homology domain-containing protein 2 (Fragment) Lrch2 62.2 68.7 59.3 54.1 61.3 57.4 1.10069444444444 0.170119828151202 0.138414028697095 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Leucine-rich repeat (LRR) protein, contains calponin homology domain Z Cytoskeleton ; IPR001611 [Leucine-rich repeat] ; IPR001715[Calponin homology domain] -- -- C6EQH2 HECT-type E3 ubiquitin transferase 83 80.2 80.2 82.6 92.7 90.6 0.91538172245205 0.0800313847384835 -0.127554609143939 Nonsignificant None 4 Molecular Function:ubiquitin-protein transferase activity (GO:0004842),Molecular Function:zinc ion binding (GO:0008270),Biological Process:protein ubiquitination (GO:0016567),Molecular Function:metal ion binding (GO:0046872) E3 ubiquitin-protein ligase HERC2 2.3.2.26 ko04120 Ubiquitin mediated proteolysis FOG: RCC1 domain S Function unknown ; IPR000408 [Regulator of chromosome condensation, RCC1] ; IPR000433[Zinc finger, ZZ-type] ; IPR000569[HECT domain] ; IPR001199[Cytochrome b5-like heme/steroid binding domain] ; IPR004939[APC10/DOC domain] ; IPR010606[Mib-herc2] ; IPR021097[CPH domain] -- -- Q5SQF8 Histone deacetylase complex subunit SAP30L Sap30l 58.3 61.9 75 64.1 57.2 67.6 1.03335097935416 0.740830079803946 0.0473303511745167 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR025717 [Histone deacetylase complex subunit SAP30 zinc-finger] ; IPR025718[Histone deacetylase complex subunit SAP30, Sin3 binding domain] -- -- P35294 Ras-related protein Rab-19 Rab19 127.6 113.1 151.4 129.4 118.1 128.5 1.04281914893617 0.671265271344567 0.0604889799515897 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-19 -- -- GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- Q3UK85 Uncharacterized protein Dctn5 481.8 455.7 419.3 491.1 482.1 491.2 0.926522807975963 0.122656290635016 -0.110101603741346 Nonsignificant None -- -- dynactin 5 -- ko04962 Vasopressin-regulated water reabsorption Dynactin, subunit p25 Z Cytoskeleton ; IPR001451 [Hexapeptide repeat] -- -- F8VQ65 Keratin-associated protein 19-5 Krtap19-5 1004.6 807.8 698.1 580.1 569.5 617.9 1.42036775106082 0.0526656587540422 0.506264509971103 Nonsignificant None -- -- -- -- -- -- -- -- IPR021743 [Keratin-associated protein, type6/8/16/19/20/21] -- -- P26450 Phosphatidylinositol 3-kinase regulatory subunit alpha Pik3r1 379.4 480.9 586 580.5 569.7 546.7 0.852318934527668 0.239306618625831 -0.230534712368025 Nonsignificant None 1 Biological Process:signal transduction (GO:0007165) phosphoinositide-3-kinase regulatory subunit alpha/beta/delta -- ko01521 EGFR tyrosine kinase inhibitor resistance ko01522 Endocrine resistance ko01524 Platinum drug resistance ko04012 ErbB signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04024 cAMP signaling pathway ko04062 Chemokine signaling pathway ko04066 HIF-1 signaling pathway ko04068 FoxO signaling pathway ko04070 Phosphatidylinositol signaling system ko04071 Sphingolipid signaling pathway ko04072 Phospholipase D signaling pathway ko04140 Autophagy - animal ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04152 AMPK signaling pathway ko04210 Apoptosis ko04211 Longevity regulating pathway ko04213 Longevity regulating pathway - multiple species ko04218 Cellular senescence ko04360 Axon guidance ko04370 VEGF signaling pathway ko04380 Osteoclast differentiation ko04510 Focal adhesion ko04550 Signaling pathways regulating pluripotency of stem cells ko04611 Platelet activation ko04620 Toll-like receptor signaling pathway ko04630 Jak-STAT signaling pathway ko04650 Natural killer cell mediated cytotoxicity ko04660 T cell receptor signaling pathway ko04662 B cell receptor signaling pathway ko04664 Fc epsilon RI signaling pathway ko04666 Fc gamma R-mediated phagocytosis ko04668 TNF signaling pathway ko04670 Leukocyte transendothelial migration ko04722 Neurotrophin signaling pathway ko04725 Cholinergic synapse ko04750 Inflammatory mediator regulation of TRP channels ko04810 Regulation of actin cytoskeleton ko04910 Insulin signaling pathway ko04914 Progesterone-mediated oocyte maturation ko04915 Estrogen signaling pathway ko04917 Prolactin signaling pathway ko04919 Thyroid hormone signaling pathway ko04923 Regulation of lipolysis in adipocytes ko04926 Relaxin signaling pathway ko04930 Type II diabetes mellitus ko04931 Insulin resistance ko04932 Non-alcoholic fatty liver disease (NAFLD) ko04933 AGE-RAGE signaling pathway in diabetic complications ko04960 Aldosterone-regulated sodium reabsorption ko04973 Carbohydrate digestion and absorption ko05100 Bacterial invasion of epithelial cells ko05142 Chagas disease (American trypanosomiasis) ko05146 Amoebiasis ko05160 Hepatitis C ko05161 Hepatitis B ko05162 Measles ko05164 Influenza A ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05205 Proteoglycans in cancer ko05210 Colorectal cancer ko05211 Renal cell carcinoma ko05212 Pancreatic cancer ko05213 Endometrial cancer ko05214 Glioma ko05215 Prostate cancer ko05218 Melanoma ko05220 Chronic myeloid leukemia ko05221 Acute myeloid leukemia ko05222 Small cell lung cancer ko05223 Non-small cell lung cancer ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer ko05230 Central carbon metabolism in cancer ko05231 Choline metabolism in cancer ko05418 Fluid shear stress and atherosclerosis Adaptor for phosphoinositide 3-kinase T Signal transduction mechanisms ; IPR000198 [Rho GTPase-activating protein domain] ; IPR000980[SH2 domain] ; IPR032498[PI3K p85 subunit, inter-SH2 domain] -- -- Q62371 Discoidin domain-containing receptor 2 Ddr2 56.3 50.7 80.8 76.3 86.7 81.4 0.768412438625205 0.124172829009169 -0.380047222164955 Nonsignificant None 2 Molecular Function:protein kinase activity (GO:0004672),Biological Process:protein phosphorylation (GO:0006468) discoidin domain receptor family member 2 2.7.10.1 -- Discoidin domain receptor DDR1 T Signal transduction mechanisms ; IPR000421 [Coagulation factor 5/8 C-terminal domain] ; IPR001245[Serine-threonine/tyrosine-protein kinase catalytic domain] -- -- Q8VD31 Tapasin-related protein Tapbpl 677.9 676.5 722.6 612 663.7 629.4 1.09023148391161 0.0556872971832495 0.124634488428467 Nonsignificant None -- -- -- -- -- -- -- -- IPR003597 [Immunoglobulin C1-set] ; IPR013106[Immunoglobulin V-set domain] -- -- P70206 Plexin-A1 Plxna1 46.1 39.3 41.8 52.5 55.9 44.7 0.830829523187459 0.0892134398696319 -0.267375612215433 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:membrane (GO:0016020) plexin A -- ko04360 Axon guidance Plexins (functional semaphorin receptors) T Signal transduction mechanisms ; IPR001627 [Sema domain] ; IPR002165[Plexin repeat] ; IPR002909[IPT domain] ; IPR013548[Plexin, cytoplasmic RasGAP domain] -- -- O35407 Receptor protein-tyrosine kinase Ddr1 118.3 106.5 127.2 126.4 125.5 141.3 0.895218718209563 0.156566198464589 -0.159687892815921 Nonsignificant None 2 Molecular Function:protein kinase activity (GO:0004672),Biological Process:protein phosphorylation (GO:0006468) discoidin domain receptor family member 1 2.7.10.1 -- Discoidin domain receptor DDR1 T Signal transduction mechanisms ; IPR000421 [Coagulation factor 5/8 C-terminal domain] ; IPR001245[Serine-threonine/tyrosine-protein kinase catalytic domain] -- -- Q6KAQ5 MFLJ00199 protein (Fragment) mFLJ00199 8.7 12 7.7 10.2 6.1 8.4 1.1497975708502 0.5219447738411 0.201379887920005 Nonsignificant None 1 Biological Process:mitochondrial fusion (GO:0008053) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019392 [Mitoguardin] -- -- D1MQ07 Small conductance calcium activated potassium channel type4 transcript variant 2 Kcnn4 31.2 23.4 25.3 30.3 29.4 21.4 0.985203452527744 0.91859797495987 -0.0215064112892962 Nonsignificant None 4 Molecular Function:calmodulin binding (GO:0005516),Biological Process:potassium ion transport (GO:0006813),Molecular Function:calcium-activated potassium channel activity (GO:0015269),Cellular Component:integral component of membrane (GO:0016021) potassium intermediate/small conductance calcium-activated channel subfamily N member 4 -- ko04911 Insulin secretion ko04970 Salivary secretion ko04974 Protein digestion and absorption Ca2+-activated K+ channel proteins (intermediate/small conductance classes) P Inorganic ion transport and metabolism ; IPR004178 [Calmodulin-binding domain] -- -- A6PWR8 Ubiquitin carboxyl-terminal hydrolase 43 Usp43 75.3 80.3 53.6 74.3 62.2 76.6 0.981698732989207 0.895950529981201 -0.026647741535762 Nonsignificant None 2 Biological Process:protein deubiquitination (GO:0016579),Molecular Function:thiol-dependent ubiquitinyl hydrolase activity (GO:0036459) ubiquitin carboxyl-terminal hydrolase 43 3.4.19.12 -- Ubiquitin C-terminal hydrolase O Posttranslational modification, protein turnover, chaperones ; IPR001394 [Peptidase C19, ubiquitin carboxyl-terminal hydrolase] -- -- Q78IK2 ATP synthase membrane subunit K, mitochondrial Atp5mk 410.6 372.2 420.1 512.5 458.5 467.3 0.836334561635264 0.024238251493265 -0.257847911125363 Nonsignificant None -- -- up-regulated during skeletal muscle growth protein 5 -- -- -- -- -- -- -- -- Q8BXQ5 Uncharacterized protein (Fragment) Cdc23 25.2 32.1 33 30.9 38.3 26.5 0.943573667711599 0.692587666447263 -0.0837929370051673 Nonsignificant None -- -- anaphase-promoting complex subunit 8 -- ko04110 Cell cycle ko04114 Oocyte meiosis ko04120 Ubiquitin mediated proteolysis ko04914 Progesterone-mediated oocyte maturation ko05166 HTLV-I infection Anaphase-promoting complex (APC), Cdc23 subunit DO Cell cycle control, cell division, chromosome partitioning ; Posttranslational modification, protein turnover, chaperones ; -- -- -- Q8VE95 UPF0598 protein C8orf82 homolog 162.4 165.3 165.4 207 214.2 210.7 0.780344991296091 0.0000360319203815938 -0.357816012969961 Nonsignificant None -- -- -- -- -- -- -- -- IPR028108 [Protein of unknown function DUF4505] -- -- Q8BVR3 AKAP7_RIRII_bdg domain-containing protein (Fragment) Akap7 284.9 283.3 342.6 340.9 338 364.2 0.873166522864538 0.105941093813189 -0.195671276312162 Nonsignificant None -- -- A-kinase anchor protein 7 -- -- -- -- -- IPR019511 [A-kinase anchor protein 7, RI-RII subunit-binding domain] -- -- A0A1Y7VNC5 Ninein Nin 797.3 1012.9 1056.2 788.3 846.2 769.8 1.19219731314728 0.138149703935668 0.253623027026086 Nonsignificant None -- -- ninein -- -- -- -- -- -- -- -- E9Q3Y7 Capping protein-inhibiting regulator of actin dynamics Cracd 47.2 50.5 43.1 64.1 61.3 53.6 0.78659217877095 0.0285318982635612 -0.346312253514321 Nonsignificant None -- -- -- -- -- -- -- -- IPR028030 [Domain of unknown function DUF4592] -- -- Q56A13 Commd7 protein Commd7 436.4 426.2 394.5 303.9 327.5 280.8 1.37809690857268 0.00338747640294365 0.462677342760179 Nonsignificant None -- -- -- -- -- -- -- -- IPR017920 [COMM domain] -- -- Q80Y98 Phospholipase DDHD2 Ddhd2 143.8 186.9 201.1 206.4 204.8 179.5 0.900287794142543 0.366677264968754 -0.151541834765042 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:metal ion binding (GO:0046872) phospholipase DDHD2 3.1.1.- -- Phosphatidic acid-preferring phospholipase A1, contains DDHD domain IU Lipid transport and metabolism ; Intracellular trafficking, secretion, and vesicular transport ; IPR001660 [Sterile alpha motif domain] ; IPR004170[WWE domain] ; IPR004177[DDHD domain] -- -- A0A087WQF7 Zinc transporter ZIP10 (Fragment) Slc39a10 217.6 184.7 179.4 179.9 169.8 185.2 1.0874929893438 0.289044651429238 0.121006100481798 Nonsignificant None -- -- solute carrier family 39 (zinc transporter), member 10 -- -- Putative zinc transporter P Inorganic ion transport and metabolism ; -- -- -- D3Z2E9 Protein FAM241B (Fragment) Fam241b 115.1 130.6 92.3 95.9 98.6 109.2 1.11294040171222 0.388916513165443 0.154376338002087 Nonsignificant None -- -- -- -- -- -- -- -- IPR027953 [Domain of unknown function DUF4605] -- -- P70188 Kinesin-associated protein 3 Kifap3 23.9 20.4 23.4 27.3 27.8 20.3 0.897877984084881 0.388622083147814 -0.155408689693668 Nonsignificant None -- -- -- -- -- Kinesin associated protein KAP U Intracellular trafficking, secretion, and vesicular transport ; -- -- -- Q6QD59 Vesicle transport protein SEC20 Bnip1 592.9 543.6 632.2 545.3 580.9 560.6 1.04855347403367 0.379012054151777 0.0684004377397059 Nonsignificant None -- -- protein transport protein SEC20 -- ko04130 SNARE interactions in vesicular transport -- -- -- IPR005606 [Sec20] -- -- B1ARC5 Zinc transporter ZIP11 (Fragment) Slc39a11 262.1 230.6 234.4 235.9 263.5 247.1 0.974012056262559 0.638929069867551 -0.0379884648769147 Nonsignificant None -- -- solute carrier family 39 (zinc transporter), member 11 -- -- Zinc transporter and related ZIP domain-containing proteins P Inorganic ion transport and metabolism ; -- -- -- Q8BWT5 Disco-interacting protein 2 homolog A Dip2a 227.1 211.4 257.4 294.3 267.2 304.5 0.803579676674365 0.0316547500852472 -0.315487017540741 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) -- -- -- Predicted AMP-binding protein R General function prediction only ; IPR000873 [AMP-dependent synthetase/ligase] ; IPR010506[DMAP1-binding domain] -- -- Q3UJY1 Uncharacterized protein Slc29a1 123.6 89.5 115.9 91 98.6 118 1.06957087126138 0.614635509733907 0.0970320806607774 Nonsignificant None 3 Molecular Function:nucleoside transmembrane transporter activity (GO:0005337),Biological Process:transport (GO:0006810),Cellular Component:integral component of membrane (GO:0016021) solute carrier family 29 (equilibrative nucleoside transporter), member 1/2/3 -- -- Nucleoside transporter F Nucleotide transport and metabolism ; IPR002259 [Equilibrative nucleoside transporter] -- -- O88968 Transcobalamin-2 Tcn2 320 305.8 270.1 270.1 264.6 278.2 1.10210357977611 0.146039928557728 0.140259820104106 Nonsignificant None 2 Biological Process:cobalamin transport (GO:0015889),Molecular Function:cobalamin binding (GO:0031419) transcobalamin-2 -- ko04977 Vitamin digestion and absorption -- -- -- IPR002157 [Cobalamin (vitamin B12)-binding transporter, eukaryotic] ; IPR027954[Domain of unknown function DUF4430] -- -- Q9QZX7 Serine racemase Srr 28.8 31.1 41.5 50.9 47.8 44.2 0.709587123862841 0.03377173968797 -0.494948264092476 Nonsignificant None -- -- serine racemase 5.1.1.18 ko00260 Glycine, serine and threonine metabolism ko01100 Metabolic pathways Serine racemase TE Signal transduction mechanisms ; Amino acid transport and metabolism ; IPR001926 [Tryptophan synthase beta subunit-like PLP-dependent enzyme] -- -- Q9R1E6 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Enpp2 43.5 44.8 63.5 53.7 46.9 38 1.0952380952381 0.607235471571836 0.131244533278252 Nonsignificant None 7 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:catalytic activity (GO:0003824),Molecular Function:scavenger receptor activity (GO:0005044),Biological Process:immune response (GO:0006955),Molecular Function:hydrolase activity (GO:0016787),Molecular Function:polysaccharide binding (GO:0030247),Molecular Function:metal ion binding (GO:0046872) ectonucleotide pyrophosphatase/phosphodiesterase family member 2 3.1.4.39 ko00565 Ether lipid metabolism Type I phosphodiesterase/nucleotide pyrophosphatase R General function prediction only ; IPR001212 [Somatomedin B domain] ; IPR001604[DNA/RNA non-specific endonuclease] ; IPR002591[Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase] -- -- F7BJB9 MORC family CW-type zinc finger protein 3 Morc3 40.1 44.7 39 39.5 38.6 39.2 1.05541346973572 0.339950461476561 0.077808301185756 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) -- -- -- MORC family ATPases D Cell cycle control, cell division, chromosome partitioning ; IPR011124 [Zinc finger, CW-type] -- -- Q91XD7 Protein disulfide isomerase Creld1 Creld1 146.4 126.8 133.5 158.5 135.1 151.8 0.91311180960934 0.226202894112426 -0.131136567325657 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR001881 [EGF-like calcium-binding domain] ; IPR021852[Domain of unknown function DUF3456] -- -- P07361 Alpha-1-acid glycoprotein 2 Orm2 56.6 51.8 34.9 11.2 10.3 18.8 3.55583126550868 0.00847506490099453 1.83018686573418 Significant up -- -- -- -- -- -- -- -- IPR000566 [Lipocalin/cytosolic fatty-acid binding domain] -- -- Q8BVR6 RING finger and SPRY domain-containing protein 1 Rspry1 7.2 7 0 7.1 5.3 5.6 1.18333333333333 0.225327680191938 0.242856523896164 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Scaffold/matrix specific factor hnRNP-U/SAF-A, contains SPRY domain A RNA processing and modification ; IPR003877 [SPRY domain] -- -- Q9D600 DNA replication complex GINS protein PSF2 Gins2 413.7 419.7 402.8 386.9 346.1 313.3 1.18149670266654 0.0442816138916967 0.24061560302884 Nonsignificant None -- -- GINS complex subunit 2 -- -- Uncharacterized conserved protein S Function unknown ; IPR021151 [GINS subunit, domain A] -- -- A0A0G2JFT3 Threonine--tRNA ligase, mitochondrial Tars2 62.2 52.6 48.1 55 55.9 58 0.964476021314387 0.662597915947142 -0.0521827242758678 Nonsignificant None -- -- threonyl-tRNA synthetase 6.1.1.3 ko00970 Aminoacyl-tRNA biosynthesis Threonyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; -- -- -- Q91V36 Nuclear receptor-binding protein 2 Nrbp2 169.8 152 176.7 186 200.9 179.8 0.879654137991883 0.0782599223141679 -0.184991697823968 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) nuclear receptor-binding protein -- -- Protein kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q80U63 Mitofusin-2 Mfn2 99 115.3 115.4 129.2 130.1 122.4 0.863767356562746 0.0439141260627518 -0.211285299545171 Nonsignificant None 4 Molecular Function:GTPase activity (GO:0003924),Cellular Component:mitochondrial outer membrane (GO:0005741),Biological Process:mitochondrial fusion (GO:0008053),Cellular Component:integral component of membrane (GO:0016021) mitofusin 2 3.6.5.- ko04137 Mitophagy - animal ko04621 NOD-like receptor signaling pathway Mitofusin 1 GTPase, involved in mitochondrila biogenesis O Posttranslational modification, protein turnover, chaperones ; IPR006884 [Fzo/mitofusin HR2 domain] ; IPR022812[Dynamin superfamily] -- -- O35239 Tyrosine-protein phosphatase non-receptor type 9 Ptpn9 91.3 101.9 69.2 88.7 99.9 108.8 0.88231338264963 0.358348988985688 -0.180636927434335 Nonsignificant None 2 Molecular Function:protein tyrosine phosphatase activity (GO:0004725),Biological Process:protein dephosphorylation (GO:0006470) tyrosine-protein phosphatase non-receptor type 9 3.1.3.48 -- -- -- -- IPR000242 [PTP type protein phosphatase] ; IPR001251[CRAL-TRIO lipid binding domain] -- -- Q91YU8 Suppressor of SWI4 1 homolog Ppan 124.1 124.2 119.8 109.5 124.6 98.5 1.10673481659651 0.199299607797068 0.146309581096792 Nonsignificant None -- -- ribosome biogenesis protein SSF1/2 -- -- RNA-binding protein required for 60S ribosomal subunit biogenesis J Translation, ribosomal structure and biogenesis ; IPR007109 [Brix domain] -- -- D6RDC6 tRNA modification GTPase GTPBP3, mitochondrial Gtpbp3 4.2 2.7 7.4 5.9 2.2 6.2 1 1 0 Nonsignificant None -- -- tRNA modification GTPase 3.6.-.- -- Mitochondrial GTPase J Translation, ribosomal structure and biogenesis ; IPR018948 [GTP-binding protein TrmE, N-terminal] ; IPR025867[MnmE, helical domain] -- -- Q7TQ95 Endoplasmic reticulum junction formation protein lunapark Lnpk 498.7 484.9 524.5 463.8 489.3 459.9 1.06730360934183 0.0992194529678536 0.0939706291952213 Nonsignificant None -- -- -- -- -- Predicted membrane protein S Function unknown ; IPR019273 [Lunapark domain] -- -- D3YWY6 Mitochondrial pyruvate carrier Mpc1 659.8 594 670.4 690.2 659.5 781.6 0.902829259137615 0.189882837212428 -0.147474920344408 Nonsignificant None 2 Cellular Component:mitochondrial inner membrane (GO:0005743),Biological Process:mitochondrial pyruvate transport (GO:0006850) mitochondrial pyruvate carrier 1 -- -- Uncharacterized conserved protein S Function unknown ; IPR005336 [Mitochondrial pyruvate carrier] -- -- E9Q8I9 Protein furry homolog Fry 58.9 55.6 58.2 43.4 46.7 54 1.19847328244275 0.0441704470477698 0.261197747354177 Nonsignificant None -- -- -- -- -- Fry-like conserved proteins R General function prediction only ; IPR025481 [Cell morphogenesis protein C-terminal] ; IPR025614[Cell morphogenesis protein N-terminal] ; IPR029473[Cell morphogenesis central region] -- -- Q8R4G6 Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A Mgat5 199.2 174.8 221.7 203.9 230 228.2 0.899713034284851 0.237406597464184 -0.152463171257203 Nonsignificant None -- -- alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 2.4.1.155 ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways -- -- -- IPR027833 [Domain of unknown function DUF4525] -- -- B2RPW2 Smith-Magenis syndrome chromosome region, candidate 7-like (Human) Mief1 41.4 39 27.5 33.6 39.2 38.6 0.968581687612208 0.813960815353358 -0.0460543678520148 Nonsignificant None -- -- -- -- -- -- -- -- IPR024810 [Mab-21 domain] -- -- Q3UC14 Sidoreflexin Sfxn2 140.2 142.5 150 160.4 155.7 163.2 0.902774880033382 0.0134663342989567 -0.147561819197071 Nonsignificant None 4 Biological Process:ion transport (GO:0006811),Molecular Function:ion transmembrane transporter activity (GO:0015075),Cellular Component:membrane (GO:0016020),Biological Process:transmembrane transport (GO:0055085) -- -- -- Sideroflexin R General function prediction only ; IPR004686 [Tricarboxylate/iron carrier] -- -- Q9D2Z1 Carcinoembryonic antigen-related cell adhesion molecule 20 Ceacam20 221.8 181.5 185.2 196.4 212.9 203.8 0.959876039797749 0.582192088904573 -0.059079989382961 Nonsignificant None -- -- carcinoembryonic antigen-related cell adhesion molecule -- -- -- -- -- IPR013098 [Immunoglobulin I-set] -- -- P22361 Hepatocyte nuclear factor 1-alpha Hnf1a 246.9 213.7 208 191.3 185.3 205.1 1.14938971978683 0.0979487892743647 0.200868050789455 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634) transcription factor 1, hepatocyte nuclear factor 1-alpha -- ko04550 Signaling pathways regulating pluripotency of stem cells ko04950 Maturity onset diabetes of the young -- -- -- IPR001356 [Homeobox domain] ; IPR006897[Hepatocyte nuclear factor 1, beta isoform, C-terminal] ; IPR006898[Hepatocyte nuclear factor 1, alpha isoform C-terminal] ; IPR006899[Hepatocyte nuclear factor 1, N-terminal] -- Homeobox Q91YE5 Bromodomain adjacent to zinc finger domain protein 2A Baz2a 34.7 28 35.7 36.4 33.7 34 0.945244956772334 0.499795777178665 -0.0812398479601772 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Molecular Function:protein binding (GO:0005515),Cellular Component:nucleus (GO:0005634) bromodomain adjacent to zinc finger domain protein 2A -- -- Chromatin remodeling complex WSTF-ISWI, large subunit (contains heterochromatin localization, PHD and BROMO domains) B Chromatin structure and dynamics ; IPR001487 [Bromodomain] ; IPR001739[Methyl-CpG DNA binding] ; IPR018501[DDT domain] ; IPR019787[Zinc finger, PHD-finger] ; IPR028941[WHIM2 domain] ; IPR028942[WHIM1 domain] -- MBD Q8VDI7 Ubiquitin-associated domain-containing protein 1 Ubac1 48.2 49.4 58 58 55.6 59.4 0.899421965317919 0.15170008295278 -0.152929977537895 Nonsignificant None -- -- Kip1 ubiquitination-promoting complex protein 2 -- -- -- -- -- IPR015940 [Ubiquitin-associated domain] -- -- Q8BSM9 Insulin-like growth factor-binding protein 4 Igfbp4 98.1 107.4 74.5 77.5 82.1 84.4 1.14754098360656 0.296342120941042 0.19854567938208 Nonsignificant None 3 Biological Process:regulation of cell growth (GO:0001558),Molecular Function:insulin-like growth factor binding (GO:0005520),Cellular Component:extracellular region (GO:0005576) -- -- -- -- -- -- IPR000716 [Thyroglobulin type-1] ; IPR000867[Insulin-like growth factor-binding protein, IGFBP] -- -- Q8BTN3 Transport and Golgi organization 2 homolog Tango2 56.9 64.9 92.3 100.3 90 86.5 0.773482658959538 0.143069176945674 -0.370559147251215 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR008551 [Transport and Golgi organisation protein 2] -- -- Q6DFV1 Condensin-2 complex subunit G2 Ncapg2 34.4 49.1 37.6 38.9 47.1 43.8 0.932973805855162 0.597186126739756 -0.10009151830481 Nonsignificant None 1 Cellular Component:nucleus (GO:0005634) condensin-2 complex subunit G2 -- -- Uncharacterized conserved protein S Function unknown ; IPR024741 [Condensin-2 complex subunit G2] -- -- Q80Y17 Lethal(2) giant larvae protein homolog 1 Llgl1 287.8 282.5 255.2 252.6 225.4 283.9 1.08347552172201 0.342206488214819 0.115666559902115 Nonsignificant None -- -- lethal(2) giant larvae protein -- ko04390 Hippo signaling pathway ko04530 Tight junction ko05165 Human papillomavirus infection Tomosyn and related SNARE-interacting proteins U Intracellular trafficking, secretion, and vesicular transport ; IPR013577 [Lethal giant larvae homologue 2] ; IPR013905[Lethal giant larvae (Lgl)-like, C-terminal domain] -- -- Q3UNL7 Uncharacterized protein Tmem251 31.4 27.4 18.7 20.6 22.8 21.5 1.19414483821263 0.331377939904714 0.255977832162461 Nonsignificant None -- -- -- -- -- -- -- -- IPR028024 [Transmembrane protein 251] -- -- Q7TPQ3 E3 ubiquitin-protein ligase SHPRH Shprh 9.2 9.7 11.3 9.2 8.1 7.5 1.21774193548387 0.089160802963469 0.284208428938204 Nonsignificant None 5 Cellular Component:nucleosome (GO:0000786),Molecular Function:DNA binding (GO:0003677),Molecular Function:ATP binding (GO:0005524),Cellular Component:nucleus (GO:0005634),Biological Process:nucleosome assembly (GO:0006334) -- -- -- DEAD box-containing helicase-like transcription factor/DNA repair protein L Replication, recombination and repair ; IPR000330 [SNF2-related, N-terminal domain] ; IPR001650[Helicase, C-terminal] ; IPR005818[Linker histone H1/H5, domain H15] -- -- A0A1Y7VN09 Nucleolar protein 8 (Fragment) Nol8 150.6 143 122 125 113 125 1.14490358126722 0.136882398949256 0.195226106021099 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- -- -- -- IPR000504 [RNA recognition motif domain] -- -- A0A2K6EDP7 WD repeat and HMG-box DNA-binding protein 1 Wdhd1 38.4 34.2 29.9 33.8 22.8 30.3 1.1795166858458 0.270292257304449 0.238195827578408 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) chromosome transmission fidelity protein 4 -- -- WD40 repeat protein R General function prediction only ; IPR001680 [WD40 repeat] ; IPR009071[High mobility group box domain] ; IPR022100[Minichromosome loss protein Mcl1, middle region] ; IPR024977[Anaphase-promoting complex subunit 4, WD40 domain] -- HMG B7ZNP2 COMM domain containing 6 Commd6 337.8 317 310.2 354.3 348.7 339.8 0.925393172228615 0.0495957272224511 -0.111861640492751 Nonsignificant None -- -- -- -- -- -- -- -- IPR017920 [COMM domain] -- -- Q3TFD2 Lysophosphatidylcholine acyltransferase 1 Lpcat1 84 99.2 101.4 103.6 112.6 114.6 0.860338573155986 0.074815287789335 -0.217023572644792 Nonsignificant None 2 Molecular Function:calcium ion binding (GO:0005509),Biological Process:metabolic process (GO:0008152) -- -- ko00564 Glycerophospholipid metabolism ko00565 Ether lipid metabolism ko01100 Metabolic pathways Predicted phosphate acyltransferase, contains PlsC domain I Lipid transport and metabolism ; IPR002048 [EF-hand domain] ; IPR002123[Phospholipid/glycerol acyltransferase] -- -- Q33DR2 All trans-polyprenyl-diphosphate synthase PDSS1 Pdss1 28.6 27.3 26.4 23.6 28.5 25.5 1.06056701030928 0.372829358057695 0.084835778234498 Nonsignificant None 1 Biological Process:isoprenoid biosynthetic process (GO:0008299) decaprenyl-diphosphate synthase subunit 1 2.5.1.91 ko00900 Terpenoid backbone biosynthesis Geranylgeranyl pyrophosphate synthase/Polyprenyl synthetase H Coenzyme transport and metabolism ; IPR000092 [Polyprenyl synthetase] -- -- Q00493 Carboxypeptidase E Cpe 487.8 470.1 585.5 686.1 646.8 704.9 0.757385415644322 0.014314568307739 -0.400900454203968 Nonsignificant None 3 Molecular Function:metallocarboxypeptidase activity (GO:0004181),Biological Process:proteolysis (GO:0006508),Molecular Function:zinc ion binding (GO:0008270) carboxypeptidase E 3.4.17.10 ko04940 Type I diabetes mellitus Zinc carboxypeptidase R General function prediction only ; IPR000834 [Peptidase M14, carboxypeptidase A] -- -- Q6PAJ1 Breakpoint cluster region protein Bcr 55.6 36.8 39.8 42.7 42.7 46.1 1.00532319391635 0.970550393295453 0.0076593773280267 Nonsignificant None 7 Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Molecular Function:GTPase activator activity (GO:0005096),Molecular Function:protein binding (GO:0005515),Biological Process:protein phosphorylation (GO:0006468),Biological Process:signal transduction (GO:0007165),Biological Process:regulation of Rho protein signal transduction (GO:0035023) breakpoint cluster region protein 2.7.11.1 ko05200 Pathways in cancer ko05220 Chronic myeloid leukemia Rac GTPase-activating protein BCR/ABR T Signal transduction mechanisms ; IPR000008 [C2 domain] ; IPR000198[Rho GTPase-activating protein domain] ; IPR000219[Dbl homology (DH) domain] ; IPR015123[Bcr-Abl oncoprotein oligomerisation] -- -- Q3TQU6 Uncharacterized protein Spin1 78 87.8 92.6 73.9 67.7 81 1.16082659478886 0.107181324112547 0.215152477351965 Nonsignificant None 1 Biological Process:gamete generation (GO:0007276) -- -- -- -- -- -- IPR003671 [Spindlin/spermiogenesis-specific protein] -- -- Q8VDD8 WASH complex subunit 1 Washc1 63.9 74.5 57.7 59.2 52.6 51.5 1.20085731781996 0.115914377527743 0.264064744630454 Nonsignificant None -- -- WAS protein family homolog 1 -- ko04144 Endocytosis -- -- -- IPR021854 [WASH1, WAHD domain] -- -- Q8BHD8 Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 Pcmtd2 220.9 268 170.3 355.2 401.9 234.9 0.664516129032258 0.12440023192241 -0.589623878091019 Nonsignificant None -- -- -- -- -- Protein-L-isoaspartate(D-aspartate) O-methyltransferase O Posttranslational modification, protein turnover, chaperones ; -- -- -- Q8VCD5 Mediator of RNA polymerase II transcription subunit 17 Med17 274.8 273.5 279.7 262.1 263.9 259.1 1.05464272067253 0.00368799543447434 0.0767543426174965 Nonsignificant None 3 Molecular Function:RNA polymerase II transcription cofactor activity (GO:0001104),Biological Process:regulation of transcription from RNA polymerase II promoter (GO:0006357),Cellular Component:mediator complex (GO:0016592) mediator of RNA polymerase II transcription subunit 17 -- ko04919 Thyroid hormone signaling pathway Vitamin D3 receptor interacting protein KT Transcription ; Signal transduction mechanisms ; IPR019313 [Mediator complex, subunit Med17] -- -- Q8R3P0 Aspartoacylase Aspa 52.1 87.6 101.4 99.9 105.6 102.4 0.783046443650536 0.267877738531605 -0.352830216442291 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) aspartoacylase 3.5.1.15 ko00250 Alanine, aspartate and glutamate metabolism ko00340 Histidine metabolism ko01100 Metabolic pathways -- -- -- IPR007036 [Succinylglutamate desuccinylase/aspartoacylase] -- -- Q6ZWZ2 Ubiquitin-conjugating enzyme E2 R2 Ube2r2 327 342.8 378.3 389.8 359.5 369.6 0.936723567789793 0.250819641321864 -0.0943047313338826 Nonsignificant None -- -- ubiquitin-conjugating enzyme E2 R 2.3.2.23 ko04120 Ubiquitin mediated proteolysis ko05168 Herpes simplex infection Ubiquitin-protein ligase O Posttranslational modification, protein turnover, chaperones ; IPR000608 [Ubiquitin-conjugating enzyme E2] -- -- H3BJY2 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Asap1 75.8 92.2 105 100.3 101 136.2 0.808888888888889 0.213717002417553 -0.305986551018341 Nonsignificant None 2 Molecular Function:GTPase activator activity (GO:0005096),Molecular Function:protein binding (GO:0005515) Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein -- ko04144 Endocytosis ko04666 Fc gamma R-mediated phagocytosis Putative GTPase activating proteins (GAPs) T Signal transduction mechanisms ; IPR001164 [Arf GTPase activating protein] ; IPR001452[SH3 domain] ; IPR001849[Pleckstrin homology domain] ; IPR020683[Ankyrin repeat-containing domain] -- -- Q8K4K6 Pantothenate kinase 1 Pank1 148.8 225.4 246.2 216.3 258.7 214.6 0.899651972157773 0.522368829098944 -0.152561088053007 Nonsignificant None 3 Molecular Function:pantothenate kinase activity (GO:0004594),Molecular Function:ATP binding (GO:0005524),Biological Process:coenzyme A biosynthetic process (GO:0015937) type II pantothenate kinase 2.7.1.33 ko00770 Pantothenate and CoA biosynthesis ko01100 Metabolic pathways Pantothenate kinase PanK and related proteins H Coenzyme transport and metabolism ; IPR004567 [Type II pantothenate kinase] -- -- P97872 Flavin-containing monooxygenase 5 Fmo5 47.1 52.9 49.2 65.7 74 61 0.743398106626806 0.0145512315089891 -0.427793081107379 Nonsignificant None 4 Molecular Function:N,N-dimethylaniline monooxygenase activity (GO:0004499),Molecular Function:flavin adenine dinucleotide binding (GO:0050660),Molecular Function:NADP binding (GO:0050661),Biological Process:oxidation-reduction process (GO:0055114) dimethylaniline monooxygenase (N-oxide forming) 1.14.13.8 ko00982 Drug metabolism - cytochrome P450 Flavin-containing monooxygenase Q Secondary metabolites biosynthesis, transport and catabolism ; IPR020946 [Flavin monooxygenase-like] -- -- Q80YV4 4-phosphopantetheine phosphatase Pank4 53 50.7 58.2 45 57.4 60.9 0.991426821800368 0.934184085998312 -0.0124218052591288 Nonsignificant None 3 Molecular Function:pantothenate kinase activity (GO:0004594),Molecular Function:ATP binding (GO:0005524),Biological Process:coenzyme A biosynthetic process (GO:0015937) type II pantothenate kinase 2.7.1.33 ko00770 Pantothenate and CoA biosynthesis ko01100 Metabolic pathways Pantothenate kinase PanK and related proteins H Coenzyme transport and metabolism ; IPR002791 [Domain of unknown function DUF89] ; IPR004567[Type II pantothenate kinase] -- -- Q9D1Q1 M-phase phosphoprotein 6 Mphosph6 172.8 158.4 171.4 153.9 153.1 172.8 1.04751979991663 0.39068340225241 0.0669775135872209 Nonsignificant None -- -- M-phase phosphoprotein 6, animal type -- ko03018 RNA degradation M phase phosphoprotein 6 D Cell cycle control, cell division, chromosome partitioning ; IPR019324 [M-phase phosphoprotein 6] -- -- B2RXC6 DNA-directed RNA polymerase subunit Polr3a 51.1 43.1 47 51.1 46 48.2 0.971782518926359 0.644284665080148 -0.041294614361661 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Molecular Function:DNA-directed 5'-3' RNA polymerase activity (GO:0003899) DNA-directed RNA polymerase III subunit RPC1 2.7.7.6 ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways ko03020 RNA polymerase ko04623 Cytosolic DNA-sensing pathway ko05169 Epstein-Barr virus infection RNA polymerase III, large subunit K Transcription ; IPR000722 [RNA polymerase, alpha subunit] ; IPR007066[RNA polymerase Rpb1, domain 3] ; IPR007080[RNA polymerase Rpb1, domain 1] ; IPR007081[RNA polymerase Rpb1, domain 5] ; IPR007083[RNA polymerase Rpb1, domain 4] -- -- Q8R3F9 Speckle targeted PIP5K1A-regulated poly(A) polymerase Tut1 71.6 78.8 58.8 59 68.6 61.8 1.10454065469905 0.367747039253613 0.143446520778557 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- S-M checkpoint control protein CID1 and related nucleotidyltransferases D Cell cycle control, cell division, chromosome partitioning ; IPR000504 [RNA recognition motif domain] ; IPR002058[PAP/25A-associated] -- -- D6RI64 Small acidic protein 1110004F10Rik 1393.5 1500.6 1527.6 1147.9 1149.8 1131.1 1.28957652823145 0.0135314767639887 0.366897390516783 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q9CQH8 Ribonuclease P protein subunit p14 Rpp14 390.7 359.6 341.5 292.7 314.1 305.9 1.19623096307659 0.0189080291989267 0.258495965719837 Nonsignificant None 2 Molecular Function:ribonuclease activity (GO:0004540),Biological Process:tRNA processing (GO:0008033) ribonuclease P protein subunit RPP14 3.1.26.5 ko03013 RNA transport -- -- -- IPR002759 [Ribonuclease P/MRP protein subunit] -- -- Z4YJL9 Intraflagellar transport protein 20 homolog (Fragment) Ift20 259.8 282 345.9 304.1 320.9 319.4 0.939961880559085 0.513023882295789 -0.0893258443135652 Nonsignificant None -- -- intraflagellar transport protein 20 -- -- -- -- -- IPR028172 [Intraflagellar transport protein 20] -- -- Q3UC00 WW domain-containing protein (Fragment) Pcif1 126.3 109.6 125.6 127.4 116.5 138.5 0.945345188284519 0.452087841156444 -0.0810868761422684 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) phosphorylated CTD-interacting factor 1 -- -- -- -- -- IPR001202 [WW domain] -- -- P56375 Acylphosphatase-2 Acyp2 223.3 181 245.6 244.6 222.3 238.9 0.920799093227543 0.40617258810752 -0.119041682134824 Nonsignificant None -- -- acylphosphatase 3.6.1.7 ko00620 Pyruvate metabolism Acylphosphatase C Energy production and conversion ; IPR001792 [Acylphosphatase-like domain] -- -- A0A140LIM2 AN1-type zinc finger protein 6 (Fragment) Zfand6 126.4 125.6 135.7 105.2 91.3 101.7 1.30013413816231 0.00484969049786399 0.378660477467738 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Molecular Function:zinc ion binding (GO:0008270) -- -- -- Predicted Zn-finger protein R General function prediction only ; IPR000058 [Zinc finger, AN1-type] ; IPR002653[Zinc finger, A20-type] -- -- Q80SX2 C4b-binding protein alpha-chain C4bp 72.8 67.2 49.2 36.4 39.6 41.3 1.61295822676897 0.0299352081416249 0.689709075310887 Significant up -- -- complement component 4 binding protein, alpha -- ko04610 Complement and coagulation cascades ko05133 Pertussis -- -- -- IPR000436 [Sushi/SCR/CCP domain] -- -- Q9D0R8 Protein LSM12 Lsm12 278.2 295.5 336.6 307.1 302.3 274.2 1.03021729289271 0.681255166002822 0.042948661987245 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019181 [Anticodon-binding domain] -- -- O35623 BET1 homolog Bet1 100.7 99.1 95.6 96.1 89.2 103.8 1.02179176755448 0.66348917854665 0.0311012172877398 Nonsignificant None -- -- blocked early in transport 1 -- ko04130 SNARE interactions in vesicular transport V-SNARE U Intracellular trafficking, secretion, and vesicular transport ; -- -- -- A0A3B2WC92 Spastin Spast 83.9 80.1 57.4 60.9 68.1 55.7 1.19870059556037 0.246543213580754 0.261471355799114 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) spastin 3.6.4.3 -- AAA+-type ATPase O Posttranslational modification, protein turnover, chaperones ; IPR003959 [ATPase, AAA-type, core] ; IPR015415[Vps4 oligomerisation, C-terminal] -- -- E9Q8P6 Protein unc-93 homolog B1 Unc93b1 45.6 42.1 25 47.8 45.8 50.1 0.784272790535839 0.186242692396637 -0.350572546285115 Nonsignificant None -- -- -- -- -- Predicted membrane protein S Function unknown ; IPR010291 [Ion channel regulatory protein, UNC-93] -- -- Q8R3C6 Probable RNA-binding protein 19 Rbm19 204.9 196.8 162.9 141.2 130.3 137.8 1.37942829220621 0.0174876022243183 0.464070462006608 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) multiple RNA-binding domain-containing protein 1 -- -- RNA-binding protein (RRM superfamily) R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- B2RWV7 2310014H01Rik protein Ppp1r18 111.1 112.4 120.1 133.7 143.9 122.6 0.858570714642679 0.0492963915841097 -0.219991130767278 Nonsignificant None 1 Molecular Function:phosphatase binding (GO:0019902) phostensin -- -- -- -- -- IPR025903 [Phostensin/Taperin N-terminal domain] ; IPR025907[Phostensin/Taperin PP1-binding domain] -- -- A0A571BEI2 AP2-associated protein kinase 1 (Fragment) Aak1 37.5 37.4 27.2 38.9 53.2 44.2 0.749082905355833 0.102092900773205 -0.416802695927408 Nonsignificant None -- -- -- -- -- ARK protein kinase family T Signal transduction mechanisms ; IPR028182 [BMP-2-inducible protein kinase, C-terminal] -- -- B0LAE4 ADP-ribosylation factor-like 6 interacting protein 1 (Fragment) Arl6ip1 930.6 965.2 1083.6 887.2 941 884.7 1.09823436175311 0.149211222682383 0.135185956401426 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- A0A494BB08 Coiled-coil domain-containing protein 88B (Fragment) Ccdc88b 67.1 64 75.3 78.8 91.6 81.9 0.81807372175981 0.0404345852479947 -0.289697235553046 Nonsignificant None -- -- -- -- -- Uncharacterized coiled-coil protein S Function unknown ; -- -- -- Q922B1 ADP-ribose glycohydrolase MACROD1 Macrod1 140.1 124 140.7 188.7 159 207.9 0.728581713462923 0.0299774695531932 -0.456837309287082 Nonsignificant None -- -- -- -- -- Hismacro and SEC14 domain-containing proteins BK Chromatin structure and dynamics ; Transcription ; IPR002589 [Macro domain] -- -- Q8R0H4 Uncharacterized protein Lypd8 1421 1067 1307 1513.8 1522.1 1335.8 0.86808335430153 0.186549137053142 -0.204094516429854 Nonsignificant None -- -- -- -- -- -- -- -- IPR016054 [Ly-6 antigen/uPA receptor-like] -- -- F6SMJ7 GTP-binding protein 8 (Fragment) Gtpbp8 39.5 42.1 35.4 38.7 49.3 39.4 0.918367346938775 0.428539554157227 -0.122856747785534 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) -- -- -- Predicted GTPase R General function prediction only ; IPR006073 [GTP binding domain] -- -- Q6A065 Centrosomal protein of 170 kDa Cep170 63.5 46.9 37.6 47 44.7 55 1.00886162235855 0.960354854828004 0.0127283048429223 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) centrosomal protein CEP170 -- -- -- -- -- IPR000253 [Forkhead-associated (FHA) domain] ; IPR029300[CEP170, C-terminal] -- -- Q5SV41 Phosphatidylcholine transfer protein Pctp 317.5 316.7 423.4 320.8 308.4 307.2 1.12943186672362 0.372276187694961 0.175597242395679 Nonsignificant None 1 Molecular Function:lipid binding (GO:0008289) -- -- -- START domain-containing proteins involved in steroidogenesis/phosphatidylcholine transfer I Lipid transport and metabolism ; IPR002913 [START domain] -- -- Q8VI23 Solute carrier family 12 member 8 Slc12a8 49.3 53 50.3 58.6 62.4 51.9 0.882591093117409 0.106716676733378 -0.180182906807751 Nonsignificant None 3 Biological Process:transport (GO:0006810),Cellular Component:membrane (GO:0016020),Biological Process:transmembrane transport (GO:0055085) solute carrier family 12 (potassium/chloride transporters), member 8 -- -- Na+/K+ symporter P Inorganic ion transport and metabolism ; IPR004841 [Amino acid permease/ SLC12A domain] -- -- Q8K339 DNA/RNA-binding protein KIN17 Kin 71 56.4 63.7 61.1 67.2 77.9 0.926770126091174 0.480096860431755 -0.109716554390652 Nonsignificant None -- -- DNA/RNA-binding protein KIN17 -- -- Protein containing a U1-type Zn-finger and implicated in RNA splicing or processing A RNA processing and modification ; IPR019447 [DNA/RNA-binding protein Kin17, conserved domain] -- -- D3YVV0 Tetratricopeptide repeat domain 13 Ttc13 47.2 44.4 35.2 35.2 41 37.6 1.11423550087873 0.339181080286862 0.156054187832825 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR001440 [Tetratricopeptide repeat 1] -- -- Q3UHE9 Uncharacterized protein (Fragment) Reps2 35.4 32.1 43.7 44.4 30.9 41.5 0.952054794520548 0.745255424611278 -0.0708834861565096 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) RalBP1-associated Eps domain-containing protein -- -- Ral-GTPase effector RALBP1 U Intracellular trafficking, secretion, and vesicular transport ; IPR000261 [EH domain] -- -- Q9D1C9 Ribosomal RNA-processing protein 7 homolog A Rrp7a 83.2 68.4 65.7 72.7 66.6 69.4 1.04120747484427 0.642466285655364 0.0582575740214479 Nonsignificant None -- -- ribosomal RNA-processing protein 7 -- ko03008 Ribosome biogenesis in eukaryotes rRNA processing protein RRP7 A RNA processing and modification ; IPR024326 [Ribosomal RNA-processing protein 7] -- -- Q3UND0 Src kinase-associated phosphoprotein 2 Skap2 193.1 196.4 210.7 161.4 180.3 161.3 1.19324055666004 0.0175657075641685 0.254884918905399 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR001452 [SH3 domain] ; IPR001849[Pleckstrin homology domain] -- -- E9PYJ6 Focadhesin Focad 53.1 52.2 56.3 56.8 57 59.6 0.931949250288351 0.062652712387019 -0.10167670047004 Nonsignificant None -- -- -- -- -- -- -- -- IPR021392 [Focadhesin] ; IPR022542[Domain of unknown function DUF3730] -- -- Q8C0T5 Signal-induced proliferation-associated 1-like protein 1 Sipa1l1 109.3 96.2 104.4 91.8 92.2 99.6 1.09273624823695 0.128527054187236 0.127945222346699 Nonsignificant None 2 Molecular Function:GTPase activator activity (GO:0005096),Biological Process:regulation of small GTPase mediated signal transduction (GO:0051056) signal-induced proliferation-associated 1 like protein 1 -- ko04015 Rap1 signaling pathway Rap1-GTPase-activating protein (Rap1GAP) T Signal transduction mechanisms ; IPR000331 [Rap GTPase activating protein domain] ; IPR021818[Signal-induced proliferation-associated 1-like protein, C-terminal] -- -- A6H630 Damage-control phosphatase ARMT1 Armt1 128.8 190.7 178.3 208.8 200.2 185.8 0.836919973100202 0.182355329714785 -0.256838417071383 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR002791 [Domain of unknown function DUF89] -- -- Q8C8G9 5-nucleotidase 23 22.3 51.1 54.7 58.7 49.8 0.590686274509804 0.086151187348518 -0.759536005741534 Nonsignificant None 2 Biological Process:nucleotide catabolic process (GO:0009166),Molecular Function:hydrolase activity (GO:0016787) 5'-nucleotidase 3.1.3.5 ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko00760 Nicotinate and nicotinamide metabolism ko01100 Metabolic pathways 5' nucleotidase F Nucleotide transport and metabolism ; IPR004843 [Calcineurin-like phosphoesterase domain, ApaH type] ; IPR008334[5'-Nucleotidase, C-terminal] -- -- Q61586 Glycerol-3-phosphate acyltransferase 1, mitochondrial Gpam 15.5 18 18.1 18.5 18 18.8 0.933092224231465 0.234524845202873 -0.099908414811453 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) glycerol-3-phosphate O-acyltransferase 1/2 2.3.1.15 ko00561 Glycerolipid metabolism ko00564 Glycerophospholipid metabolism ko01100 Metabolic pathways Mitochondrial glycerol-3-phosphate acyltransferase GPAT I Lipid transport and metabolism ; IPR002123 [Phospholipid/glycerol acyltransferase] -- -- A0A1B0GSA2 Growth hormone-regulated TBC protein 1 Grtp1 331.3 332.2 494.6 452.4 437.2 471.7 0.85073091897451 0.287040909702154 -0.233225206510257 Nonsignificant None -- -- TBC1 domain family member 6 -- -- Ypt/Rab GTPase activating protein U Intracellular trafficking, secretion, and vesicular transport ; IPR000195 [Rab-GTPase-TBC domain] -- -- Q3U6U3 ADP-ribosylation factor-like protein 6 Arl6 165.5 144.9 154.4 136.4 150.3 161.1 1.03796337650737 0.575335113588288 0.0537555405519312 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) ADP-ribosylation factor-like protein 6 -- -- GTP-binding ADP-ribosylation factor Arf1 U Intracellular trafficking, secretion, and vesicular transport ; IPR006689 [Small GTPase superfamily, ARF/SAR type] -- -- Q91VW0 Adenine nucleotide translocase lysine N-methyltransferase Antkmt 312.2 313.1 414.6 345.4 419.2 388.2 0.90206453851492 0.401747942835269 -0.14869743960563 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; -- -- -- Q501J7 Phosphatase and actin regulator 4 Phactr4 27.1 36.3 25.3 36.8 25.4 38.1 0.884346959122632 0.504573467324354 -0.177315596311117 Nonsignificant None -- -- phosphatase and actin regulator 4 -- -- RPEL repeat-containing protein R General function prediction only ; IPR004018 [RPEL repeat] -- -- Q3V403 Signal-induced proliferation-associated protein 1 Sipa1 11.9 16 12.6 15.7 18.8 12.1 0.869098712446352 0.429038155819001 -0.202408046882293 Nonsignificant None 3 Molecular Function:GTPase activator activity (GO:0005096),Molecular Function:protein binding (GO:0005515),Biological Process:regulation of small GTPase mediated signal transduction (GO:0051056) signal-induced proliferation-associated gene 1 -- ko04015 Rap1 signaling pathway ko04670 Leukocyte transendothelial migration Rap1-GTPase-activating protein (Rap1GAP) T Signal transduction mechanisms ; IPR000331 [Rap GTPase activating protein domain] ; IPR001478[PDZ domain] -- -- A0JNU3 60 kDa lysophospholipase Aspg 132.6 111.8 100.8 134.1 118.7 123.8 0.916622411046203 0.369748444209703 -0.125600535435273 Nonsignificant None -- -- -- -- -- Asparaginase E Amino acid transport and metabolism ; IPR027474 [L-asparaginase, N-terminal] -- -- Q3U0U7 LRRCT domain-containing protein Cd180 99.5 107.7 107.4 129.4 125.5 124.6 0.828985507246377 0.00211816336623848 -0.270581214887142 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) CD180 antigen -- -- FOG: Toll/interleukin receptor and related proteins containing LRR and TIR repeats T Signal transduction mechanisms ; IPR001611 [Leucine-rich repeat] -- -- G3X8U8 Poly(ADP-ribose) glycohydrolase Parg 247.3 260.3 312.9 285.5 330.1 309 0.887410772225827 0.219140529511757 -0.172326028834866 Nonsignificant None 2 Molecular Function:poly(ADP-ribose) glycohydrolase activity (GO:0004649),Biological Process:carbohydrate metabolic process (GO:0005975) poly(ADP-ribose) glycohydrolase 3.2.1.143 -- Poly(ADP-ribose) glycohydrolase T Signal transduction mechanisms ; IPR007724 [Poly(ADP-ribose) glycohydrolase] -- -- Q9CXA2 Trans-L-3-hydroxyproline dehydratase L3hypdh 68.8 70.2 81.1 92.2 86.5 96.7 0.79920116194626 0.0194942008980337 -0.323369414243407 Nonsignificant None -- -- trans-L-3-hydroxyproline dehydratase 4.2.1.77 ko00330 Arginine and proline metabolism -- -- -- IPR008794 [Proline racemase family] -- -- B7ZMW5 cDNA sequence X99384 Pald1 47.8 45.4 47.5 51.7 67 67.9 0.754019292604502 0.0976607169821235 -0.407326657615226 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q8BVU5 ADP-ribose pyrophosphatase, mitochondrial Nudt9 231.8 222.8 218.7 256 271.6 259.3 0.85563604015758 0.00347514240037495 -0.22493084349525 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) ADP-ribose pyrophosphatase 3.6.1.13 ko00230 Purine metabolism Transient receptor potential-related channel 7 P Inorganic ion transport and metabolism ; IPR000086 [NUDIX hydrolase domain] -- -- Q60848 Lymphocyte-specific helicase Hells 97.9 90.6 130.2 135.3 131.2 107.1 0.853051391862955 0.289862579841041 -0.229295435931809 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) ATP-dependent DNA helicase -- -- Chromatin remodeling complex WSTF-ISWI, small subunit K Transcription ; IPR000330 [SNF2-related, N-terminal domain] ; IPR001650[Helicase, C-terminal] -- -- H7BX38 Stromal cell-derived factor 1 Cxcl12 148.6 168.5 178.3 181.7 146.1 138.7 1.06195069667738 0.577085670809612 0.0867167875072421 Nonsignificant None 3 Cellular Component:extracellular region (GO:0005576),Biological Process:immune response (GO:0006955),Molecular Function:chemokine activity (GO:0008009) C-X-C motif chemokine 12 -- ko04060 Cytokine-cytokine receptor interaction ko04062 Chemokine signaling pathway ko04064 NF-kappa B signaling pathway ko04360 Axon guidance ko04670 Leukocyte transendothelial migration ko04672 Intestinal immune network for IgA production ko05200 Pathways in cancer ko05323 Rheumatoid arthritis -- -- -- IPR001811 [Chemokine interleukin-8-like domain] -- -- P16254 Signal recognition particle 14 kDa protein Srp14 517.3 518.6 582.5 573.1 568.9 575 0.942574257425743 0.265784143924873 -0.0853218143312136 Nonsignificant None 3 Biological Process:SRP-dependent cotranslational protein targeting to membrane (GO:0006614),Molecular Function:7S RNA binding (GO:0008312),Molecular Function:endoplasmic reticulum signal peptide binding (GO:0030942) signal recognition particle subunit SRP14 -- ko03060 Protein export Signal recognition particle, subunit Srp14 U Intracellular trafficking, secretion, and vesicular transport ; IPR003210 [Signal recognition particle, SRP14 subunit] -- -- Q80YA7 Dipeptidyl peptidase 8 Dpp8 358.9 342 265.7 286.4 277.5 320.9 1.09245027124774 0.436549989298298 0.127567609193018 Nonsignificant None 2 Biological Process:proteolysis (GO:0006508),Molecular Function:serine-type peptidase activity (GO:0008236) dipeptidyl-peptidase 8 3.4.14.5 -- Dipeptidyl aminopeptidases/acylaminoacyl-peptidases O Posttranslational modification, protein turnover, chaperones ; IPR001375 [Peptidase S9, prolyl oligopeptidase, catalytic domain] ; IPR002469[Dipeptidylpeptidase IV, N-terminal domain] -- -- F8TZM2 Polyprotein (Fragment) 231 255.8 216.2 159.8 222.1 207.3 1.19314324507807 0.160619995187707 0.254767258924048 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:viral capsid (GO:0019028) -- -- -- -- -- -- IPR000840 [Gamma-retroviral matrix protein] -- -- A0A087WRH2 Fas apoptotic inhibitory molecule 1 (Fragment) Faim 133.8 133.4 86.3 95.3 99.4 116.8 1.13483146067416 0.458653827932165 0.182478051785397 Nonsignificant None 1 Biological Process:negative regulation of apoptotic process (GO:0043066) -- -- -- Fas-mediated apoptosis inhibitor FAIM T Signal transduction mechanisms ; IPR010695 [Fas apoptotic inhibitory molecule 1] -- -- Q8VHH5 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 Agap3 42 36.7 36.3 36 41.6 39.2 0.98458904109589 0.818630958477589 -0.0224064130482797 Nonsignificant None 3 Molecular Function:GTPase activator activity (GO:0005096),Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1/3 -- ko04144 Endocytosis GTPase-activating protein Centaurin gamma (contains Ras-like GTPase, PH and ankyrin repeat domains) T Signal transduction mechanisms ; IPR001164 [Arf GTPase activating protein] ; IPR001806[Small GTPase superfamily] ; IPR020683[Ankyrin repeat-containing domain] -- -- Q8K426 Resistin-like gamma Retnlg 427.1 869.8 437.4 84.9 104.3 84.6 6.33418553688824 0.0789721065050118 2.66315912648013 Nonsignificant None 2 Molecular Function:hormone activity (GO:0005179),Cellular Component:extracellular region (GO:0005576) -- -- -- -- -- -- IPR009714 [Resistin] -- -- A0A494BA71 Protein YIF1 Yif1a 120.9 119.6 118.1 107.5 132.3 113.6 1.01471420486701 0.838375609209604 0.0210734483167578 Nonsignificant None -- -- protein transport protein YIF1 -- -- Predicted membrane protein S Function unknown ; IPR005578 [Yif1 family] -- -- B9EJ70 Dedicator of cytokinesis 8 Dock8 225.4 220 195.3 198.2 186.2 191.2 1.11309937456567 0.0934319556643444 0.154582398423962 Nonsignificant None -- -- dedicator of cytokinesis protein 6/7/8 -- -- PH domain-containing protein T Signal transduction mechanisms ; IPR010703 [Dedicator of cytokinesis, C-terminal] ; IPR021816[Dedicator of cytokinesis C/D, N-terminal] ; IPR027007[DHR-1 domain] -- -- E9Q967 Segment polarity protein dishevelled homolog DVL-3 Dvl3 58 45 36.5 50.7 52.8 52.9 0.891943734015345 0.46304772599071 -0.164975390590802 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Biological Process:intracellular signal transduction (GO:0035556) segment polarity protein dishevelled -- ko04150 mTOR signaling pathway ko04310 Wnt signaling pathway ko04330 Notch signaling pathway ko04390 Hippo signaling pathway ko04550 Signaling pathways regulating pluripotency of stem cells ko04916 Melanogenesis ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05200 Pathways in cancer ko05217 Basal cell carcinoma ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer Dishevelled 3 and related proteins R General function prediction only ; IPR000591 [DEP domain] ; IPR001158[DIX domain] ; IPR001478[PDZ domain] ; IPR003351[Dishevelled protein domain] ; IPR024580[Dishevelled C-terminal] -- -- Q9D4L6 E3 ubiquitin-protein ligase Rnf220 Rnf220 133.4 132.7 117.9 129.9 130.6 132.6 0.97685067412872 0.610925331075497 -0.0337900528155755 Nonsignificant None 2 Biological Process:protein ubiquitination (GO:0016567),Biological Process:positive regulation of canonical Wnt signaling pathway (GO:0090263) -- -- -- -- -- -- IPR031824 [E3 ubiquitin-protein ligase RNF220, middle domain] -- -- Q91Z92 Beta-1,3-galactosyltransferase 6 B3galt6 136 139.4 167.9 185.6 218.8 182.1 0.755839727195226 0.0366694772255946 -0.403847745750606 Nonsignificant None 3 Biological Process:protein glycosylation (GO:0006486),Molecular Function:galactosyltransferase activity (GO:0008378),Cellular Component:membrane (GO:0016020) galactosylxylosylprotein 3-beta-galactosyltransferase 2.4.1.134 ko00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin ko01100 Metabolic pathways Galactosyltransferases G Carbohydrate transport and metabolism ; IPR002659 [Glycosyl transferase, family 31] -- -- Q8VI93 2-5-oligoadenylate synthase 3 Oas3 52.7 45.7 65.9 54.5 63.1 61.7 0.916341327384272 0.484268790429003 -0.1260430079183 Nonsignificant None 1 Molecular Function:nucleotidyltransferase activity (GO:0016779) 2'-5'-oligoadenylate synthetase 2.7.7.84 ko04621 NOD-like receptor signaling pathway ko05160 Hepatitis C ko05162 Measles ko05164 Influenza A ko05168 Herpes simplex infection -- -- -- IPR002934 [Polymerase, nucleotidyl transferase domain] ; IPR018952[2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal] -- -- A0A0R4J1R9 ERI1 exoribonuclease 3 (Fragment) Eri3 41.6 42.8 48.1 42.9 37.9 44.4 1.05830670926518 0.434097574624768 0.0817577974053055 Nonsignificant None -- -- ERI1 exoribonuclease 3 3.1.-.- -- Predicted exonuclease L Replication, recombination and repair ; IPR013520 [Exonuclease, RNase T/DNA polymerase III] -- -- Q3TDL0 PCI domain-containing protein Cops7b 147.1 163.2 153.3 154.3 134.7 153.6 1.04744690465432 0.428288171617704 0.0668771152054601 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) COP9 signalosome complex subunit 7 -- -- COP9 signalosome, subunit CSN7 OT Posttranslational modification, protein turnover, chaperones ; Signal transduction mechanisms ; IPR000717 [Proteasome component (PCI) domain] -- -- A0A0R4IZZ6 Formin-binding protein 4 Fnbp4 160.1 184.6 215.4 194.6 188.6 188.2 0.98022401120056 0.836472968869421 -0.0288166079890139 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR001202 [WW domain] -- -- Q9ESU8 Amino acid transporter Slc1a4 47.6 45.6 72 66.8 63.7 52.9 0.900763358778626 0.556804938685795 -0.150779952175609 Nonsignificant None 2 Molecular Function:symporter activity (GO:0015293),Cellular Component:integral component of membrane (GO:0016021) solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 -- -- Glutamate/aspartate and neutral amino acid transporters E Amino acid transport and metabolism ; IPR001991 [Sodium:dicarboxylate symporter] -- -- A0A141CM24 NADH-ubiquinone oxidoreductase chain 4 ND4 136.9 156.5 220.1 244.6 218.2 199.8 0.774977361907637 0.153658938061843 -0.367773926875457 Nonsignificant None 1 Biological Process:oxidation-reduction process (GO:0055114) NADH-ubiquinone oxidoreductase chain 4 1.6.5.3 ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko05012 Parkinson's disease NADH dehydrogenase, subunit 4 C Energy production and conversion ; IPR000260 [NADH:ubiquinone oxidoreductase chain 4, N-terminal] ; IPR001750[NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit] -- -- A2ATN9 Serine/threonine-protein kinase Nek6 Nek6 129.9 115.2 75.8 83.9 92.7 90.5 1.20142268813179 0.33472114206003 0.264743813646698 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) NIMA (never in mitosis gene a)-related kinase 6 2.7.11.1 -- NIMA (never in mitosis)-related G2-specific serine/threonine protein kinase D Cell cycle control, cell division, chromosome partitioning ; IPR000719 [Protein kinase domain] -- -- E9Q109 60S ribosome subunit biogenesis protein NIP7 homolog Nip7 245.3 241.7 184.4 157.7 163.4 205 1.2761832351264 0.121729827517548 0.351835486962761 Nonsignificant None -- -- 60S ribosome subunit biogenesis protein NIP7 -- -- Ribosome biogenesis protein NIP7 J Translation, ribosomal structure and biogenesis ; -- -- -- Q9R0L7 A-kinase anchor protein 8-like Akap8l 33.2 31.6 36 33 32.4 29.6 1.06105263157895 0.308538232574606 0.0854962202816064 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634) A-kinase anchor protein 8-like protein -- ko05169 Epstein-Barr virus infection -- -- -- IPR007071 [A-kinase anchoring protein 95 (AKAP95)] -- -- O54818 Tumor protein D53 Tpd52l1 17.5 21.5 20.6 22 31.8 19.2 0.816438356164384 0.327465011228 -0.292584133305218 Nonsignificant None -- -- -- -- -- Coiled-coil protein TPD52 R General function prediction only ; IPR007327 [Tumour protein D52] -- -- Q8BK58 HSPB1-associated protein 1 Hspbap1 18 21.6 20.1 21.8 21.5 22.5 0.907294832826748 0.134270903892607 -0.140356652470436 Nonsignificant None -- -- HSPB1-associated protein 1 -- -- Uncharacterized conserved protein, contains JmjC domain BT Chromatin structure and dynamics ; Signal transduction mechanisms ; -- -- -- Q9CQE4 C-type lectin domain-containing protein (Fragment) Reg3a 96.6 82.1 240.4 47.2 60 48.6 2.68998716302952 0.223897642474344 1.42759928806895 Nonsignificant None -- -- -- -- -- C-type lectin TV Signal transduction mechanisms ; Defense mechanisms ; IPR001304 [C-type lectin-like] -- -- Q00724 Retinol-binding protein 4 Rbp4 84 72.8 52.2 65.7 66.2 70.2 1.03414151410193 0.828978511752768 0.0484336205885097 Nonsignificant None -- -- retinol-binding protein 4 -- -- -- -- -- IPR000566 [Lipocalin/cytosolic fatty-acid binding domain] -- -- Q9DBB5 Eukaryotic translation initiation factor 4E type 3 Eif4e3 16.2 68.2 107.4 94.2 104.5 51.5 0.766586730615508 0.564084354441474 -0.383479069147689 Nonsignificant None 4 Molecular Function:RNA binding (GO:0003723),Molecular Function:translation initiation factor activity (GO:0003743),Cellular Component:cytoplasm (GO:0005737),Biological Process:translational initiation (GO:0006413) -- -- -- -- -- -- IPR001040 [Translation Initiation factor eIF- 4e] -- -- A0A068BIT0 Solute carrier family 39 Slc39a7 309 306.6 355.3 337.2 350.9 325.4 0.957967439565861 0.462106352273744 -0.0619514739730543 Nonsignificant None 4 Cellular Component:membrane (GO:0016020),Biological Process:metal ion transport (GO:0030001),Molecular Function:metal ion transmembrane transporter activity (GO:0046873),Biological Process:transmembrane transport (GO:0055085) solute carrier family 39 (zinc transporter), member 7 -- -- Putative zinc transporter P Inorganic ion transport and metabolism ; IPR003689 [Zinc/iron permease] -- -- Q9Z0E0 Neurochondrin Ncdn 55.8 50.3 58 61.9 62.6 50.7 0.936643835616438 0.455654129312421 -0.0944275360874608 Nonsignificant None -- -- -- -- -- Neurochondrin/leucine-rich protein (Neurochondrin) S Function unknown ; IPR008709 [Neurochondrin] -- -- E9Q6M6 Mitochondrial glutamate carrier 1 Slc25a22 445.1 389.7 487.4 431.7 446 424.8 1.01512476007678 0.83178435969788 0.0216570472952498 Nonsignificant None -- -- solute carrier family 25 (mitochondrial glutamate transporter), member 18/22 -- -- Mitochondrial solute carrier protein C Energy production and conversion ; IPR018108 [Mitochondrial substrate/solute carrier] -- -- E9Q6A7 Bromodomain PHD finger transcription factor Bptf 145.4 163.1 147.5 175.2 178.1 189.7 0.839779005524862 0.0152346533015893 -0.25191837363962 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) nucleosome-remodeling factor subunit BPTF -- -- Nucleosome remodeling factor, subunit NURF301/BPTF BK Chromatin structure and dynamics ; Transcription ; IPR001487 [Bromodomain] ; IPR018501[DDT domain] ; IPR019787[Zinc finger, PHD-finger] ; IPR028941[WHIM2 domain] ; IPR028942[WHIM1 domain] -- -- Q9CQL5 39S ribosomal protein L18, mitochondrial Mrpl18 189.1 184.5 172.5 189.1 161.7 177.4 1.03388867853086 0.558231522567208 0.048080855307171 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L18 -- ko03010 Ribosome Mitochondrial/chloroplast ribosomal protein L18 J Translation, ribosomal structure and biogenesis ; IPR005484 [Ribosomal protein L18] -- -- P58069 Ras GTPase-activating protein 2 Rasa2 164 170 190.1 172.4 178.1 184.9 0.978894284646993 0.686710540450084 -0.0307750300028622 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Biological Process:intracellular signal transduction (GO:0035556),Biological Process:regulation of GTPase activity (GO:0043087) Ras GTPase-activating protein 2 -- ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko05203 Viral carcinogenesis Ras GTPase-activating protein T Signal transduction mechanisms ; IPR000008 [C2 domain] ; IPR001562[Zinc finger, Btk motif] ; IPR001849[Pleckstrin homology domain] ; IPR001936[Ras GTPase-activating protein] -- -- Q7TSS2 Ubiquitin-conjugating enzyme E2 Q1 Ube2q1 43.7 41.2 45.6 42.5 45.1 46.8 0.970982142857143 0.506809117838593 -0.0424833313215134 Nonsignificant None -- -- ubiquitin-conjugating enzyme E2 Q 2.3.2.23 ko04120 Ubiquitin mediated proteolysis Predicted ubiquitin-conjugating enzyme O Posttranslational modification, protein turnover, chaperones ; IPR000608 [Ubiquitin-conjugating enzyme E2] -- -- Q8C774 Dual-specificity kinase Dyrk1a 206.3 189.5 209.9 194.6 185.3 187.4 1.06768905341089 0.136685419984788 0.0944915473817119 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) dual specificity tyrosine-phosphorylation-regulated kinase 1 2.7.12.1 -- Dual-specificity tyrosine-phosphorylation regulated kinase R General function prediction only ; IPR000719 [Protein kinase domain] -- -- A0A0N4SUY1 Transmembrane protein 176B (Fragment) Tmem176b 133.7 124.4 84.1 69.8 90.9 78.7 1.42940685045948 0.104967756777431 0.515416607545911 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) -- -- -- -- -- -- IPR007237 [CD20-like family] -- -- Q7TNS2 MICOS complex subunit Mic10 Micos10 312.3 360.8 456.6 573.3 531.4 470.3 0.717269841269841 0.0458825286235155 -0.479412123206511 Nonsignificant None -- -- mitochondrial inner membrane organizing system protein 1 -- -- Uncharacterized conserved protein S Function unknown ; IPR007512 [Protein of unknown function DUF543] -- -- G3UYL7 Protein FAM13A Fam13a 174.2 156.9 137.7 142.1 129.7 144.8 1.12530004800768 0.205490685250097 0.170309730381601 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q3U1Q7 Uncharacterized protein (Fragment) Smg5 63.7 68.1 66.5 82 84.3 80 0.805115712545676 0.000862482974278781 -0.312731950270113 Nonsignificant None -- -- protein SMG5 -- ko03015 mRNA surveillance pathway Nonsense-mediated mRNA decay protein A RNA processing and modification ; IPR018834 [DNA/RNA-binding domain, Est1-type] ; IPR019458[Telomerase activating protein Est1] -- -- Q91WC9 Diacylglycerol lipase-beta Daglb 39.7 37.7 43.4 37.2 38.8 34.1 1.09718437783833 0.174957149795114 0.13380598576071 Nonsignificant None 1 Biological Process:lipid metabolic process (GO:0006629) sn1-specific diacylglycerol lipase 3.1.1.- ko04723 Retrograde endocannabinoid signaling ko04925 Aldosterone synthesis and secretion Predicted lipase/calmodulin-binding heat-shock protein IOT Lipid transport and metabolism ; Posttranslational modification, protein turnover, chaperones ; Signal transduction mechanisms ; IPR002921 [Fungal lipase-like domain] -- -- Q9ES78 Intestinal peptide transporter PEPT1 Pept1 99.7 82.4 81.1 118.3 109.7 117.7 0.761353774949378 0.0141047568506958 -0.393361114527157 Nonsignificant None 3 Molecular Function:transporter activity (GO:0005215),Biological Process:transport (GO:0006810),Cellular Component:membrane (GO:0016020) solute carrier family 15 (oligopeptide transporter), member 1 -- ko04974 Protein digestion and absorption H+/oligopeptide symporter E Amino acid transport and metabolism ; IPR000109 [Proton-dependent oligopeptide transporter family] -- -- P20067 DNA-binding protein inhibitor ID-1 Id1 48.9 115.2 72.3 84.9 112.8 77.9 0.857764876632801 0.586915457004336 -0.221345852526759 Nonsignificant None 1 Molecular Function:protein dimerization activity (GO:0046983) DNA-binding protein inhibitor ID1 -- ko04015 Rap1 signaling pathway ko04350 TGF-beta signaling pathway ko04390 Hippo signaling pathway ko04550 Signaling pathways regulating pluripotency of stem cells -- -- -- IPR011598 [Myc-type, basic helix-loop-helix (bHLH) domain] -- bHLH Q80ZU0 ADP-ribosylation factor-like protein 5A Arl5a 41.2 39.8 35.7 37.7 40.5 44.8 0.948780487804878 0.471389320910971 -0.0758537545192542 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) ADP-ribosylation factor-like protein 5A -- -- GTP-binding ADP-ribosylation factor Arf1 U Intracellular trafficking, secretion, and vesicular transport ; IPR006689 [Small GTPase superfamily, ARF/SAR type] -- -- Q811J3 Iron-responsive element-binding protein 2 Ireb2 92.8 107.4 128.3 146.9 114.6 138.8 0.82063452410692 0.166054306756856 -0.285188245177847 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) RNA-binding translational regulator IRP (aconitase superfamily) AJ RNA processing and modification ; Translation, ribosomal structure and biogenesis ; IPR000573 [Aconitase A/isopropylmalate dehydratase small subunit, swivel domain] ; IPR001030[Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain] -- -- F7CC56 RB1-inducible coiled-coil protein 1 (Fragment) Rb1cc1 75.6 68.5 69.5 79.2 71 79.6 0.929503916449086 0.205381493949377 -0.105467150958559 Nonsignificant None -- -- RB1-inducible coiled-coil protein 1 -- ko04140 Autophagy - animal ko04211 Longevity regulating pathway Predicted DNA-binding transcription factor, interacts with stathmin KRT Transcription ; General function prediction only ; Signal transduction mechanisms ; IPR019460 [Autophagy-related protein 11] -- -- A0A1Y7VK09 Ryanodine receptor 2 (Fragment) Ryr2 38.7 42.2 37.1 43.6 52.1 50 0.809883321894303 0.0357968749886268 -0.304214017815309 Nonsignificant None -- -- ryanodine receptor 2 -- ko04020 Calcium signaling pathway ko04024 cAMP signaling pathway ko04260 Cardiac muscle contraction ko04261 Adrenergic signaling in cardiomyocytes ko04371 Apelin signaling pathway ko04713 Circadian entrainment ko04911 Insulin secretion ko04921 Oxytocin signaling pathway ko04972 Pancreatic secretion ko05410 Hypertrophic cardiomyopathy (HCM) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05414 Dilated cardiomyopathy (DCM) Ca2+ release channel (ryanodine receptor) T Signal transduction mechanisms ; -- -- -- A0A5F8MP92 Exocyst complex component Exoc6 170.9 185.6 174.5 199.1 207.4 192.6 0.886329494241362 0.0210808868251828 -0.174084972473613 Nonsignificant None 2 Cellular Component:exocyst (GO:0000145),Biological Process:vesicle docking involved in exocytosis (GO:0006904) exocyst complex component 6 -- -- Exocyst complex, subunit SEC15 U Intracellular trafficking, secretion, and vesicular transport ; IPR007225 [Exocyst complex component EXOC6/Sec15] -- -- Q3V0T8 Uncharacterized protein Ggps1 209.9 203.6 285.2 296.9 278.4 283.6 0.813482361159623 0.116968240102402 -0.297817030788487 Nonsignificant None 1 Biological Process:isoprenoid biosynthetic process (GO:0008299) -- -- ko00900 Terpenoid backbone biosynthesis ko01100 Metabolic pathways Geranylgeranyl pyrophosphate synthase/Polyprenyl synthetase H Coenzyme transport and metabolism ; IPR000092 [Polyprenyl synthetase] -- -- Q2I0J8 von Willebrand factor Vwf 182.9 166.2 162.4 165.3 179.2 178.1 0.978760045924225 0.656632957127535 -0.0309728846873297 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) von Willebrand factor -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04610 Complement and coagulation cascades ko04611 Platelet activation ko05165 Human papillomavirus infection von Willebrand factor and related coagulation proteins WV Extracellular structures ; Defense mechanisms ; IPR001007 [VWFC domain] ; IPR001846[von Willebrand factor, type D domain] ; IPR002035[von Willebrand factor, type A] ; IPR002919[Trypsin Inhibitor-like, cysteine rich domain] ; IPR014853[Uncharacterised domain, cysteine-rich] ; IPR032361[von Willebrand factor, VWA N-terminal domain] -- -- Q6ZPP3 MKIAA1507 protein (Fragment) Urgcp 32.4 31.1 29.9 29.3 26.7 29.8 1.08857808857809 0.102738002604925 0.122444902210116 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- D3Z3L3 Tripartite motif-containing 12C Trim12c 352.6 337.7 392.9 335 397.8 346.4 1.00370644922165 0.960645769671667 0.00533739062672917 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Cellular Component:intracellular (GO:0005622),Molecular Function:zinc ion binding (GO:0008270) tripartite motif-containing protein 5 2.3.2.27 -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR000315 [B-box-type zinc finger] ; IPR003877[SPRY domain] -- -- Q8BYW1 Rho GTPase-activating protein 25 Arhgap25 190.3 201.3 172.3 152.6 182.7 150.9 1.15981077745784 0.124286066831054 0.213889449584642 Nonsignificant None 1 Biological Process:signal transduction (GO:0007165) Rho GTPase-activating protein 22/24/25 -- -- GTPase-activator protein T Signal transduction mechanisms ; IPR000198 [Rho GTPase-activating protein domain] ; IPR001849[Pleckstrin homology domain] -- -- A0A0R4J291 FAST kinase domain-containing protein 5, mitochondrial Fastkd5 126.8 125.7 109.1 113 113 112.2 1.06918982850384 0.306127949666082 0.0965180180052045 Nonsignificant None 1 Molecular Function:protein kinase activity (GO:0004672) -- -- -- -- -- -- IPR010622 [FAST kinase leucine-rich] ; IPR013579[FAST kinase-like protein, subdomain 2] ; IPR013584[RAP domain] -- -- Q8K1N2 Pleckstrin homology-like domain family B member 2 Phldb2 150.3 138.2 140.7 147.1 146.3 159.9 0.946834326053386 0.234622088463042 -0.0788160851294634 Nonsignificant None -- -- -- -- -- -- -- -- IPR001849 [Pleckstrin homology domain] -- -- A0A1B0GRJ5 Predicted gene 45799 (Fragment) Gm45799 42.2 25.5 33.2 36.2 29.8 31.9 1.03064351378958 0.856333950875657 0.0435454095026624 Nonsignificant None -- -- mitochondrial import inner membrane translocase subunit TIM10B -- -- Mitochondrial import inner membrane translocase, subunit TIM9 U Intracellular trafficking, secretion, and vesicular transport ; -- -- -- A2AJI1 MAP7 domain-containing protein 1 Map7d1 169.3 163 190.4 204.3 169.3 183.8 0.937746681019017 0.427283190521737 -0.0927298431439164 Nonsignificant None 2 Biological Process:microtubule cytoskeleton organization (GO:0000226),Cellular Component:microtubule cytoskeleton (GO:0015630) MAP7 domain-containing protein 1 -- -- -- -- -- IPR008604 [Microtubule-associated protein 7 family] -- -- Q8VCU2 Phosphatidylinositol-glycan-specific phospholipase D Gpld1 262.1 238.7 281.1 248.1 250.1 240 1.05919804930913 0.313485095366388 0.0829723702953102 Nonsignificant None -- -- glycosylphosphatidylinositol phospholipase D 3.1.4.50 ko00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Vitronectin receptor, alpha subunit W Extracellular structures ; IPR013517 [FG-GAP repeat] ; IPR029002[Phospholipase C/D] -- -- E0CZ22 Maestro heat-like repeat family member 1 Mroh1 97.9 104.8 105.5 90.2 90.9 94.2 1.11950599346168 0.0157228719869625 0.162862251919224 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; -- -- -- P01631 Ig kappa chain V-II region 26-10 33.7 36.2 25.6 28.7 25.6 33.1 1.09267734553776 0.523702846937887 0.127867453422513 Nonsignificant None -- -- -- -- -- -- -- -- IPR013106 [Immunoglobulin V-set domain] -- -- Q8CH72 E3 ubiquitin-protein ligase TRIM32 Trim32 174 167.2 174.2 201.9 178.7 191.3 0.901206504633677 0.0565908720424751 -0.150070368343668 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) tripartite motif-containing protein 32 2.3.2.27 ko04120 Ubiquitin mediated proteolysis Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR001258 [NHL repeat] ; IPR027370[RING-type zinc-finger, LisH dimerisation motif] -- -- A0A0R4J1R7 4a-hydroxytetrahydrobiopterin dehydratase Pcbd2 472.5 472.2 605 719.9 669.8 704.9 0.739854864890671 0.0176282351377094 -0.434685805549055 Nonsignificant None 2 Biological Process:tetrahydrobiopterin biosynthetic process (GO:0006729),Molecular Function:4-alpha-hydroxytetrahydrobiopterin dehydratase activity (GO:0008124) 4a-hydroxytetrahydrobiopterin dehydratase 4.2.1.96 ko00790 Folate biosynthesis Pterin carbinolamine dehydratase PCBD/dimerization cofactor of HNF1 K Transcription ; IPR001533 [Transcriptional coactivator/pterin dehydratase] -- -- A0A0G2JE02 PAX-interacting protein 1 Paxip1 30.4 22.9 29.1 31.5 37.2 25.2 0.877529286474973 0.409675160468579 -0.188480820470556 Nonsignificant None -- -- PAX-interacting protein 1 -- -- Signaling protein SWIFT and related BRCT domain proteins KTDL Transcription ; Signal transduction mechanisms ; Cell cycle control, cell division, chromosome partitioning ; Replication, recombination and repair ; -- -- -- B2RUG9 Adenomatosis polyposis coli Apc 12.3 15.2 16.5 11.8 15.3 17.4 0.98876404494382 0.939154317071611 -0.0163018123291005 Nonsignificant None 4 Molecular Function:protein binding (GO:0005515),Molecular Function:beta-catenin binding (GO:0008013),Molecular Function:microtubule binding (GO:0008017),Biological Process:Wnt signaling pathway (GO:0016055) adenomatosis polyposis coli protein -- ko04310 Wnt signaling pathway ko04390 Hippo signaling pathway ko04550 Signaling pathways regulating pluripotency of stem cells ko04810 Regulation of actin cytoskeleton ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05200 Pathways in cancer ko05206 MicroRNAs in cancer ko05210 Colorectal cancer ko05213 Endometrial cancer ko05217 Basal cell carcinoma ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer Beta-catenin-binding protein APC, contains ARM repeats TZ Signal transduction mechanisms ; Cytoskeleton ; IPR000225 [Armadillo] ; IPR009223[Adenomatous polyposis coli protein repeat] ; IPR009224[SAMP] ; IPR009232[EB-1 binding] ; IPR009234[Adenomatous polyposis coli protein basic domain] ; IPR009240[Adenomatous polyposis coli protein, 15 residue repeat] ; IPR032038[Adenomatous polyposis coli, N-terminal dimerisation domain] -- -- Q0PD31 Rab24 Rab24 104.1 114.1 80.5 76.3 80.4 90.8 1.20686868686869 0.191012264469873 0.271268712456456 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-24 -- -- GTPase Rab5/YPT51 and related small G protein superfamily GTPases U Intracellular trafficking, secretion, and vesicular transport ; IPR001806 [Small GTPase superfamily] -- -- Q3UNM8 Uncharacterized protein Cdkn2b 39.6 44.1 41.2 46.8 32.2 46.1 0.998401278976819 0.989865250435586 -0.00230831255786248 Nonsignificant None -- -- cyclin-dependent kinase inhibitor 2B -- ko04068 FoxO signaling pathway ko04110 Cell cycle ko04218 Cellular senescence ko04350 TGF-beta signaling pathway ko05166 HTLV-I infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05222 Small cell lung cancer ko05226 Gastric cancer FOG: Ankyrin repeat R General function prediction only ; IPR020683 [Ankyrin repeat-containing domain] -- -- A0A1L1SSS4 Nuclear receptor coactivator 7 Ncoa7 36.8 35.6 41.8 34 40.5 28.6 1.10766246362755 0.39968414124527 0.147518317994734 Nonsignificant None -- -- -- -- -- Oxidation resistance protein L Replication, recombination and repair ; IPR006571 [TLDc domain] ; IPR018392[LysM domain] -- -- B2RY70 4933407C03Rik protein Cmip 11.2 11.5 12.1 7.9 5.5 7.5 1.66507177033493 0.00418282257277147 0.735584363767846 Significant up -- -- -- -- -- -- -- -- -- -- -- Q8BPG2 Yae1_N domain-containing protein Yae1d1 91.6 93.5 83.8 95.3 94.8 94.1 0.946164672765658 0.226643823448234 -0.0798367993699075 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019191 [Essential protein Yae1, N-terminal] -- -- Q61084 Mitogen-activated protein kinase kinase kinase 3 Map3k3 68.9 58.7 61.3 75.9 62.4 71.3 0.901240458015267 0.240213289416741 -0.150016015149081 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) mitogen-activated protein kinase kinase kinase 3 2.7.11.25 ko04010 MAPK signaling pathway ko04722 Neurotrophin signaling pathway ko04912 GnRH signaling pathway ko05166 HTLV-I infection MEKK and related serine/threonine protein kinases T Signal transduction mechanisms ; IPR000270 [PB1 domain] ; IPR000719[Protein kinase domain] -- -- Q9WU79 Proline dehydrogenase 1, mitochondrial Prodh 72.5 76.1 81.1 71.6 66.8 76 1.07136194029851 0.2341757618488 0.0994459509201512 Nonsignificant None -- -- proline dehydrogenase 1.5.-.- ko00330 Arginine and proline metabolism ko01100 Metabolic pathways Proline oxidase E Amino acid transport and metabolism ; IPR002872 [Proline dehydrogenase domain] -- -- Q91YL7 PGAP2-interacting protein Cwh43 23.7 53.9 40.7 47.2 31.5 33.9 1.050621669627 0.858732422750778 0.071243246259559 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q3UUQ7 GPI inositol-deacylase Pgap1 20 8 15.9 16.5 6.1 16.1 1.1343669250646 0.741208355081353 0.181887373390948 Nonsignificant None -- -- glycosylphosphatidylinositol deacylase 3.-.-.- ko00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis ko01100 Metabolic pathways Negative regulator of COPII vesicle formation U Intracellular trafficking, secretion, and vesicular transport ; IPR012908 [GPI inositol-deacylase PGAP1-like] -- -- G3X963 ATPase family AAA domain-containing protein 2 Atad2 105.2 114.3 92.6 92.8 106.7 85.4 1.0954720954721 0.364174140925969 0.131552735595359 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524) AAA+-type ATPase containing the bromodomain O Posttranslational modification, protein turnover, chaperones ; IPR001487 [Bromodomain] ; IPR003959[ATPase, AAA-type, core] -- -- Q3TCC3 PDZ domain-containing protein Cytip 718.3 879.9 202.8 1363.8 1681.8 864 0.460660937180274 0.0884853341778653 -1.11822282845304 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- FOG: PDZ domain S Function unknown ; IPR001478 [PDZ domain] -- -- Q9JJR8 Transmembrane protein 9B Tmem9b 358 360.3 441.5 375.3 403 390.1 0.992639507018144 0.924983222425367 -0.0106582198967869 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR008853 [TMEM9] -- -- Q3UK41 HDAg domain-containing protein Nelfa 134.4 112 88.5 95 85.9 103 1.17964071856287 0.295630777650433 0.238347526982324 Nonsignificant None -- -- negative elongation factor A -- -- -- -- -- -- -- -- Q3U0A9 F-BAR domain-containing protein (Fragment) Fchsd2 222.8 203.5 205.5 233.9 243.1 269.7 0.846122940940137 0.0362619951039777 -0.241060793955319 Nonsignificant None -- -- F-BAR and double SH3 domains protein -- -- Cdc42-interacting protein CIP4 Z Cytoskeleton ; IPR001060 [FCH domain] -- -- Q8BZT5 Leucine-rich repeat-containing protein 19 Lrrc19 55.6 44.7 50.3 68.4 77.1 72.9 0.68956043956044 0.00495133444588195 -0.536251086247924 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- FOG: Leucine rich repeat R General function prediction only ; IPR001611 [Leucine-rich repeat] -- -- Q9QUN3 B-cell linker protein Blnk 232 212.5 247 191.7 220.4 208.4 1.11442385173247 0.142795975430112 0.156298041020138 Nonsignificant None -- -- B-cell linker protein -- ko04064 NF-kappa B signaling pathway ko04380 Osteoclast differentiation ko04662 B cell receptor signaling pathway ko05340 Primary immunodeficiency -- -- -- IPR000980 [SH2 domain] -- -- A0A0R4J0T0 Iron-sulfur cluster co-chaperone protein HscB Hscb 261.4 266.2 278.3 324.4 305.1 298.4 0.868520314689083 0.0118325634277513 -0.203368500921828 Nonsignificant None 1 Biological Process:protein oligomerization (GO:0051259) molecular chaperone HscB -- -- Mitochondrial J-type chaperone O Posttranslational modification, protein turnover, chaperones ; IPR009073 [Co-chaperone HscB, C-terminal oligomerisation domain] -- -- Q9D0K1 Peroxisomal membrane protein PEX13 Pex13 23.8 23.5 23.4 22.8 18.8 16.9 1.20854700854701 0.143629996402744 0.273273590338632 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Cellular Component:peroxisome (GO:0005777),Cellular Component:integral component of membrane (GO:0016021) peroxin-13 -- ko04146 Peroxisome Peroxisomal biogenesis protein peroxin U Intracellular trafficking, secretion, and vesicular transport ; IPR001452 [SH3 domain] ; IPR007223[Peroxin 13, N-terminal] -- -- Q6PFQ7 Ras GTPase-activating protein 4 Rasa4 128.2 130.8 121.2 152.8 155.5 151.7 0.826521739130435 0.000989655088389866 -0.274875329183186 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Biological Process:intracellular signal transduction (GO:0035556),Biological Process:regulation of GTPase activity (GO:0043087) Ras GTPase-activating protein 4 -- ko04014 Ras signaling pathway Ras GTPase-activating protein T Signal transduction mechanisms ; IPR000008 [C2 domain] ; IPR001562[Zinc finger, Btk motif] ; IPR001849[Pleckstrin homology domain] ; IPR001936[Ras GTPase-activating protein] -- -- Q8R3K3 Pentatricopeptide repeat-containing protein 2, mitochondrial Ptcd2 154.6 170.7 114.3 208.2 227.1 164.4 0.733033183258296 0.0999088054004155 -0.448049586516553 Nonsignificant None -- -- pentatricopeptide repeat domain-containing protein 2 -- -- -- -- -- IPR019266 [Ribosomal protein S27, mitochondrial] -- -- Q3U5F4 Threonylcarbamoyl-AMP synthase Yrdc 210.6 214.8 201.7 213.3 212.5 202.3 0.998407896831715 0.952325594478182 -0.00229874975481088 Nonsignificant None 1 Molecular Function:double-stranded RNA binding (GO:0003725) -- -- -- RNA binding/translational regulation protein of the SUA5 family J Translation, ribosomal structure and biogenesis ; IPR006070 [YrdC-like domain] -- -- A0A2I3BPX9 ETS-related transcription factor Elf-1 Elf1 304.5 277.4 322.8 251.8 254.1 227.1 1.23424283765348 0.0221615447991866 0.303626273102677 Nonsignificant None 1 Molecular Function:sequence-specific DNA binding (GO:0043565) E74-like factor 1/2/4 -- Transcription factor NERF and related proteins, contain ETS domain K Transcription ; IPR000418 [Ets domain] ; IPR022084[Transcription factor Elf, N-terminal] -- ETS Q0VDP2 Slc2a13 protein Slc2a13 40.1 36.3 42.9 50.3 53.4 44.4 0.805536799459824 0.0421757590289134 -0.31197759759362 Nonsignificant None 3 Cellular Component:integral component of membrane (GO:0016021),Molecular Function:transmembrane transporter activity (GO:0022857),Biological Process:transmembrane transport (GO:0055085) MFS transporter, SP family, solute carrier family 2 (myo-inositol transporter), member 13 -- -- Predicted transporter (major facilitator superfamily) R General function prediction only ; IPR005828 [Major facilitator, sugar transporter-like] -- -- Q9CR25 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 Dph2 74.6 80.7 56 74.1 72.5 75.9 0.949662921348315 0.666235356963614 -0.0745125688061818 Nonsignificant None -- -- diphthamide biosynthesis protein 2 -- -- Diphthamide biosynthesis protein J Translation, ribosomal structure and biogenesis ; IPR016435 [Diphthamide synthesis DPH1/DPH2] -- -- A2ARA8 Integrin alpha-8 Itga8 68.1 59.9 80.8 83.4 85.2 81.3 0.835534213685474 0.0910525979181455 -0.259229189516819 Nonsignificant None -- -- integrin alpha 8 -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04514 Cell adhesion molecules (CAMs) ko04810 Regulation of actin cytoskeleton ko05165 Human papillomavirus infection ko05410 Hypertrophic cardiomyopathy (HCM) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05414 Dilated cardiomyopathy (DCM) Vitronectin receptor, alpha subunit W Extracellular structures ; IPR013517 [FG-GAP repeat] ; IPR013649[Integrin alpha-2] ; IPR018184[Integrin alpha chain, C-terminal cytoplasmic region, conserved site] -- -- E9PYP2 Neurobeachin-like 1 Nbeal1 44 41.6 42.6 51.1 52.8 46.1 0.854666666666667 0.0269030648745687 -0.226566238764502 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Kinase A-anchor protein Neurobeachin and related BEACH and WD40 repeat proteins U Intracellular trafficking, secretion, and vesicular transport ; IPR000409 [BEACH domain] ; IPR001680[WD40 repeat] ; IPR023362[PH-BEACH domain] ; IPR031570[Domain of unknown function DUF4704] -- -- A0A1D5RLL3 Protein EFR3 homolog A Efr3a 25.5 21 15.1 21 27.4 31.6 0.77 0.227699110901635 -0.377069649079823 Nonsignificant None -- -- protein EFR3 -- -- Putative transmembrane protein cmp44E R General function prediction only ; -- -- -- F8WGX5 DmX-like protein 1 Dmxl1 303 282.5 328.6 328.9 324 326.1 0.933707865168539 0.245322784413585 -0.0989568590834156 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- RAVE (regulator of V-ATPase assembly) complex subunit RAV1/DMX protein, WD repeat superfamily R General function prediction only ; IPR001680 [WD40 repeat] ; IPR022033[RAVE complex protein Rav1 C-terminal] -- -- Q8R5A0 N-lysine methyltransferase SMYD2 Smyd2 118.3 114 123.1 109.1 112.2 125.3 1.02538949798038 0.62912598038057 0.0361720268685085 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) SET and MYND domain-containing protein -- -- Predicted histone tail methylase containing SET domain B Chromatin structure and dynamics ; IPR001214 [SET domain] ; IPR002893[Zinc finger, MYND-type] -- -- P52875 Transmembrane protein 165 Tmem165 129 126.5 103.9 90.8 92.2 91.3 1.31024425811156 0.0705002439649953 0.389835786661664 Nonsignificant None -- -- -- -- -- Predicted membrane protein S Function unknown ; IPR001727 [Gdt1 family] -- -- Q05CS3 Cyp39a1 protein Cyp39a1 145.6 152.1 175.3 187.5 183.6 203.4 0.823324630113142 0.0356777692606087 -0.280466709306718 Nonsignificant None 3 Molecular Function:iron ion binding (GO:0005506),Molecular Function:heme binding (GO:0020037),Biological Process:oxidation-reduction process (GO:0055114) 24-hydroxycholesterol 7alpha-hydroxylase 1.14.14.26 ko00120 Primary bile acid biosynthesis Cytochrome P450 Q Secondary metabolites biosynthesis, transport and catabolism ; IPR001128 [Cytochrome P450] -- -- A0A0R4J0R3 Interferon-stimulated 20 kDa exonuclease-like 2 Isg20l2 82.3 78.7 78.6 45.4 37.7 44.9 1.871875 0.00017765088664118 0.904484097901423 Significant up -- -- interferon-stimulated 20 kDa exonuclease-like 2 3.1.-.- -- 3'-5' exonuclease L Replication, recombination and repair ; IPR013520 [Exonuclease, RNase T/DNA polymerase III] -- -- E9PUW6 Cardiolipin synthase (CMP-forming) Crls1 59.5 52.7 84.9 66.1 61.6 65.5 1.02018633540373 0.907116448943036 0.0288326822077125 Nonsignificant None -- -- cardiolipin synthase (CMP-forming) 2.7.8.41 ko00564 Glycerophospholipid metabolism ko01100 Metabolic pathways CDP-alcohol phosphatidyltransferase/Phosphatidylglycerol-phosphate synthase I Lipid transport and metabolism ; -- -- -- A0A0U1RNN2 CD2 antigen cytoplasmic tail-binding protein 2 Cd2bp2 54.5 50.5 51.9 39.9 46.9 44.6 1.19406392694064 0.0230321363844169 0.255880076645768 Nonsignificant None -- -- CD2 antigen cytoplasmic tail-binding protein 2 -- -- Uncharacterized protein involved in protein-protein interaction, contains polyproline-binding GYF domain R General function prediction only ; -- -- -- A0A2I3BRP6 Triple functional domain protein Trio 135 113.2 108.5 101.2 95.3 106.3 1.17800528401585 0.109578528949733 0.23634601048108 Nonsignificant None 3 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Molecular Function:protein binding (GO:0005515),Biological Process:regulation of Rho protein signal transduction (GO:0035023) triple functional domain protein 2.7.11.1 -- Multidomain protein, contains SPEC repeats, PH, SH3, and separate rac-specific and rho-specific guanine nucleotide exchange factor domains T Signal transduction mechanisms ; IPR000219 [Dbl homology (DH) domain] ; IPR001251[CRAL-TRIO lipid binding domain] ; IPR001452[SH3 domain] ; IPR001849[Pleckstrin homology domain] ; IPR002017[Spectrin repeat] -- -- Q9QXX3 Group 10 secretory phospholipase A2 Pla2g10 71.7 64.4 55.2 66.4 73.6 76.9 0.881973259566621 0.208195406576521 -0.181193179326161 Nonsignificant None 3 Molecular Function:phospholipase A2 activity (GO:0004623),Biological Process:phospholipid metabolic process (GO:0006644),Biological Process:arachidonic acid secretion (GO:0050482) secretory phospholipase A2 3.1.1.4 ko00564 Glycerophospholipid metabolism ko00565 Ether lipid metabolism ko00590 Arachidonic acid metabolism ko00591 Linoleic acid metabolism ko00592 alpha-Linolenic acid metabolism ko01100 Metabolic pathways ko04014 Ras signaling pathway ko04270 Vascular smooth muscle contraction ko04972 Pancreatic secretion ko04975 Fat digestion and absorption Phospholipase A2 I Lipid transport and metabolism ; IPR016090 [Phospholipase A2 domain] -- -- E9PZG9 Small nuclear ribonucleoprotein E (Fragment) Snrpe 38.3 57.3 59.9 56.6 48 50.1 1.00517129928895 0.972549076799981 0.00744138356892887 Nonsignificant None -- -- small nuclear ribonucleoprotein E -- ko03040 Spliceosome -- -- -- IPR001163 [LSM domain, eukaryotic/archaea-type] -- -- Q8CIV8 Tubulin-specific chaperone E Tbce 82 83.8 90.1 80.6 74.7 76.5 1.10396893874029 0.0560224627473939 0.142699581032975 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) tubulin-specific chaperone E -- -- Beta-tubulin folding cofactor E O Posttranslational modification, protein turnover, chaperones ; IPR000626 [Ubiquitin domain] ; IPR000938[CAP Gly-rich domain] -- -- A2BEF2 Disks large homolog 3 Dlg3 98 82 56 77.5 77.1 76.7 1.02031993082577 0.909858491351506 0.0290215936130134 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) discs large protein 3 -- ko04390 Hippo signaling pathway ko04530 Tight junction ko05165 Human papillomavirus infection Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) F Nucleotide transport and metabolism ; IPR001452 [SH3 domain] ; IPR001478[PDZ domain] ; IPR008145[Guanylate kinase/L-type calcium channel beta subunit] -- -- Q9CV28 Ubiquitin carboxyl-terminal hydrolase MINDY-3 Mindy3 134.3 167.6 165.1 162 157.1 140.7 1.01565898216616 0.857043754684415 0.0224160838788443 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR025257 [Domain of unknown function DUF4205] -- -- Q80YR2 FHF complex subunit HOOK interacting protein 2B Fhip2b 63.6 70.4 68.4 80.6 89.8 84.8 0.793103448275862 0.00620109095983889 -0.334419039070559 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019384 [Retinoic acid induced 16-like protein] -- -- Q8VCH7 Retinol dehydrogenase 10 Rdh10 81.4 89.4 74.5 70 69 61.7 1.22222222222222 0.0419226663780596 0.289506617194985 Nonsignificant None -- -- retinol dehydrogenase 10 1.1.1.- ko00830 Retinol metabolism ko01100 Metabolic pathways Hydroxysteroid 17-beta dehydrogenase 11 Q Secondary metabolites biosynthesis, transport and catabolism ; IPR002347 [Short-chain dehydrogenase/reductase SDR] -- -- Q6P0X6 Glrx2 protein (Fragment) Glrx2 471.1 453.3 585.2 547.1 506.6 542.6 0.945686900958467 0.540694008360569 -0.0805654813036684 Nonsignificant None 3 Molecular Function:electron carrier activity (GO:0009055),Molecular Function:protein disulfide oxidoreductase activity (GO:0015035),Biological Process:cell redox homeostasis (GO:0045454) glutaredoxin 3 -- -- Glutaredoxin and related proteins O Posttranslational modification, protein turnover, chaperones ; IPR002109 [Glutaredoxin] -- -- O88396 GrpE protein homolog 2, mitochondrial Grpel2 64.3 63 64.8 67.8 63.1 70.9 0.95193260654113 0.237529921875448 -0.0710686554408302 Nonsignificant None 4 Molecular Function:adenyl-nucleotide exchange factor activity (GO:0000774),Biological Process:protein folding (GO:0006457),Molecular Function:protein homodimerization activity (GO:0042803),Molecular Function:chaperone binding (GO:0051087) molecular chaperone GrpE -- -- Molecular chaperone of the GrpE family O Posttranslational modification, protein turnover, chaperones ; IPR000740 [GrpE nucleotide exchange factor] -- -- B2RXZ9 Myosin light chain kinase 2, skeletal/cardiac muscle Mylk2 58.4 52.6 53.6 57.4 49.5 53.3 1.02746566791511 0.639589151565652 0.0390901880129157 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) myosin-light-chain kinase 2.7.11.18 ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04270 Vascular smooth muscle contraction ko04371 Apelin signaling pathway ko04510 Focal adhesion ko04611 Platelet activation ko04810 Regulation of actin cytoskeleton ko04921 Oxytocin signaling pathway ko04971 Gastric acid secretion Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q64726 Zinc-alpha-2-glycoprotein Azgp1 204.9 199.6 185.7 131.3 144.1 142.3 1.41297581996648 0.00118683688280248 0.498736777269214 Nonsignificant None -- -- -- -- -- -- -- -- IPR003597 [Immunoglobulin C1-set] ; IPR011161[MHC class I-like antigen recognition-like] -- -- Q3UY43 Uncharacterized protein (Fragment) Txnrd3 86.6 89.3 75.3 96.1 89.8 80.9 0.941529235382309 0.445463809224907 -0.086922202292958 Nonsignificant None 5 Molecular Function:electron carrier activity (GO:0009055),Molecular Function:protein disulfide oxidoreductase activity (GO:0015035),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:cell redox homeostasis (GO:0045454),Biological Process:oxidation-reduction process (GO:0055114) thioredoxin reductase (NADPH) 1.8.1.9 ko00450 Selenocompound metabolism ko05200 Pathways in cancer ko05225 Hepatocellular carcinoma Thioredoxin reductase O Posttranslational modification, protein turnover, chaperones ; IPR002109 [Glutaredoxin] ; IPR004099[Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain] ; IPR023753[FAD/NAD(P)-binding domain] -- -- Q640L6 Atf2 protein Atf2 368.2 375.9 403.3 395.9 412.2 388.5 0.958883503259234 0.267616958723441 -0.0605725450029869 Nonsignificant None 1 Molecular Function:sequence-specific DNA binding (GO:0043565) cyclic AMP-dependent transcription factor ATF-2 -- ko04010 MAPK signaling pathway ko04022 cGMP-PKG signaling pathway ko04151 PI3K-Akt signaling pathway ko04211 Longevity regulating pathway ko04261 Adrenergic signaling in cardiomyocytes ko04668 TNF signaling pathway ko04728 Dopaminergic synapse ko04911 Insulin secretion ko04915 Estrogen signaling pathway ko04918 Thyroid hormone synthesis ko04922 Glucagon signaling pathway ko04925 Aldosterone synthesis and secretion ko04926 Relaxin signaling pathway ko05030 Cocaine addiction ko05031 Amphetamine addiction ko05034 Alcoholism ko05161 Hepatitis B ko05164 Influenza A ko05166 HTLV-I infection ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis Transcriptional activator FOSB/c-Fos and related bZIP transcription factors K Transcription ; IPR004827 [Basic-leucine zipper domain] -- TF_bZIP A0A1Y7VMS4 Nucleolar protein 7 (Fragment) Nol7 198.9 183.4 208.8 213.5 199.8 182.8 0.991612145613152 0.892271952109374 -0.0121521527199355 Nonsignificant None 1 Cellular Component:nucleus (GO:0005634) -- -- -- -- -- -- IPR012579 [Nucleolar protein 7, C-terminal] -- -- Q6P1H4 Exostoses (Multiple)-like 3 Extl3 43.4 40.5 45.9 59.8 46.7 42.6 0.870556673373575 0.300642165726943 -0.199989874284304 Nonsignificant None 3 Biological Process:glycosaminoglycan biosynthetic process (GO:0006024),Biological Process:heparan sulfate proteoglycan biosynthetic process (GO:0015012),Cellular Component:integral component of membrane (GO:0016021) -- -- ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin ko01100 Metabolic pathways Exostosin EXT1L T Signal transduction mechanisms ; IPR004263 [Exostosin-like] ; IPR015338[Exostosin , C-terminal] -- -- Q3UGS4 Mapk-regulated corepressor-interacting protein 1 Mcrip1 391.4 378.3 357.7 318.1 335.8 317.3 1.16083196046128 0.0106536698129897 0.21515914588553 Nonsignificant None -- -- -- -- -- -- -- -- IPR029428 [Mapk-regulated corepressor-interacting protein] -- -- Q8K262 Placenta-specific protein 9 Plac9 365.2 305.7 230.5 240 242 316.5 1.12886662492173 0.500763160623585 0.174875042416764 Nonsignificant None -- -- -- -- -- -- -- -- IPR027941 [Placenta-specific protein 9] -- -- G5E8P1 Bromodomain-containing protein 1 Brd1 268.4 281.4 241.8 198.2 191 229.2 1.28007761966365 0.0250503777989334 0.356231293122665 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) bromodomain-containing protein 1 -- -- PHD finger protein BR140/LIN-49 R General function prediction only ; IPR000313 [PWWP domain] ; IPR001487[Bromodomain] ; IPR019542[Enhancer of polycomb-like, N-terminal] -- -- Q8BP56 Protein-glucosylgalactosylhydroxylysine glucosidase Pgghg 343.6 345.8 362.9 327.1 339.1 336.5 1.04946644061035 0.0805391162488082 0.0696560334817826 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:carbohydrate metabolic process (GO:0005975) protein-glucosylgalactosylhydroxylysine glucosidase 3.2.1.107 -- Acid trehalase G Carbohydrate transport and metabolism ; IPR005195 [Glycoside hydrolase, family 65, central catalytic] -- -- Q3UZV9 MEKK4_N domain-containing protein Map3k4 30.9 28.3 27.2 27.9 31.3 34.4 0.923076923076923 0.331572103453657 -0.115477217419936 Nonsignificant None -- -- mitogen-activated protein kinase kinase kinase 4 2.7.11.25 ko04010 MAPK signaling pathway ko04912 GnRH signaling pathway MAPKKK (MAP kinase kinase kinase) SSK2 and related serine/threonine protein kinases T Signal transduction mechanisms ; -- -- -- Q9QY93 dCTP pyrophosphatase 1 Dctpp1 206.8 241.5 202.2 206.6 182.9 198.4 1.10648069399558 0.216123108565576 0.145978279046899 Nonsignificant None 1 Molecular Function:nucleoside-triphosphate diphosphatase activity (GO:0047429) dCTP diphosphatase 3.6.1.12 ko00240 Pyrimidine metabolism ko01100 Metabolic pathways -- -- -- IPR025984 [dCTP pyrophosphatase 1] -- -- Q3UHC2 Leucine-rich repeat serine/threonine-protein kinase 1 Lrrk1 256.5 251.4 227.8 200.1 205.7 229.2 1.15858267716535 0.0555929653746812 0.212360999472892 Nonsignificant None 6 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Molecular Function:GTP binding (GO:0005525),Biological Process:protein phosphorylation (GO:0006468),Biological Process:small GTPase mediated signal transduction (GO:0007264) leucine-rich repeat kinase 1 2.7.11.1 -- FOG: Leucine rich repeat R General function prediction only ; IPR000719 [Protein kinase domain] ; IPR001611[Leucine-rich repeat] ; IPR013684[Mitochondrial Rho-like] ; IPR020683[Ankyrin repeat-containing domain] ; IPR032171[C-terminal of Roc (COR) domain] -- -- H7BX59 tRNA pseudouridine synthase A Pus1 245.3 227 198.6 285.6 304.5 283.3 0.768147469658805 0.0112129533415603 -0.380544787428168 Nonsignificant None 4 Biological Process:pseudouridine synthesis (GO:0001522),Molecular Function:RNA binding (GO:0003723),Biological Process:RNA modification (GO:0009451),Molecular Function:pseudouridine synthase activity (GO:0009982) tRNA pseudouridine38-40 synthase 5.4.99.12 -- Pseudouridylate synthase J Translation, ribosomal structure and biogenesis ; IPR020097 [Pseudouridine synthase I, TruA, alpha/beta domain] -- -- Q9JIB0 Ran guanine nucleotide release factor Rangrf 227.6 253 165.7 131.3 142.2 153.3 1.51429240862231 0.0518429067241445 0.598643815453514 Nonsignificant None -- -- -- -- -- RAN guanine nucleotide release factor T Signal transduction mechanisms ; IPR007681 [Ran-interacting Mog1 protein] -- -- F7A6K2 Zinc finger CCHC domain-containing protein 9 (Fragment) Zcchc9 238.5 219.2 210.5 214.3 214.4 199.1 1.06435170436445 0.237781630920864 0.0899749537528548 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:zinc ion binding (GO:0008270) zinc finger CCHC domain-containing protein 9 -- -- E3 ubiquitin ligase interacting with arginine methyltransferase O Posttranslational modification, protein turnover, chaperones ; IPR001878 [Zinc finger, CCHC-type] -- -- Q3V0N4 Bms1-type G domain-containing protein (Fragment) Bms1 83.5 90.5 91.5 76.9 79.7 78.6 1.12882653061224 0.0188048770293424 0.174823800855152 Nonsignificant None 2 Cellular Component:nucleus (GO:0005634),Biological Process:ribosome biogenesis (GO:0042254) ribosome biogenesis protein BMS1 -- ko03008 Ribosome biogenesis in eukaryotes GTP-binding protein AARP2 involved in 40S ribosome biogenesis J Translation, ribosomal structure and biogenesis ; IPR007034 [Ribosome biogenesis protein BMS1/TSR1, C-terminal] ; IPR012948[AARP2CN] -- -- P86792 C-C motif chemokine 21b Ccl21b 397 399.5 319.8 247.1 286.3 256.4 1.41339579640415 0.019252867072632 0.49916552338658 Nonsignificant None 3 Cellular Component:extracellular region (GO:0005576),Biological Process:immune response (GO:0006955),Molecular Function:chemokine activity (GO:0008009) C-C motif chemokine 21 -- ko04060 Cytokine-cytokine receptor interaction ko04062 Chemokine signaling pathway ko04064 NF-kappa B signaling pathway -- -- -- IPR001811 [Chemokine interleukin-8-like domain] -- -- A6PWX8 Ubiquinol-cytochrome-c reductase complex assembly factor 1 (Fragment) Uqcc1 209.9 206.7 205.8 196.6 218.2 219.1 0.981858337277173 0.634398012838783 -0.0264132076699046 Nonsignificant None -- -- cytochrome b pre-mRNA-processing protein 3 -- -- Ubiquinol cytochrome c reductase assembly protein CBP3 C Energy production and conversion ; IPR021150 [Ubiquinol-cytochrome c chaperone/UPF0174] -- -- E9Q4N7 AT-rich interactive domain-containing protein 1B Arid1b 149.5 162 164.6 178.7 177.6 177.9 0.891239236241108 0.0526717589288729 -0.166115347078772 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) AT-rich interactive domain-containing protein 1 -- ko05225 Hepatocellular carcinoma SWI-SNF chromatin-remodeling complex protein B Chromatin structure and dynamics ; IPR001606 [ARID DNA-binding domain] ; IPR033388[SWI/SNF-like complex subunit BAF250, C-terminal] -- ARID Q3UXS5 Uncharacterized protein Ghdc 106.8 104.2 164 153.3 143.5 144.8 0.849184782608696 0.373147876886795 -0.235849576507564 Nonsignificant None -- -- -- -- -- -- -- -- IPR004993 [GH3 family] -- -- Q569X3 U1 small nuclear ribonucleoprotein C Snrpc 229.2 181.9 303.6 293.1 302.9 354.7 0.751761859682339 0.12231308307428 -0.411652372167984 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) U1 small nuclear ribonucleoprotein C -- ko03040 Spliceosome U1 snRNP-specific protein C A RNA processing and modification ; IPR013085 [Zinc finger, U1-C type] -- -- P59648 FXYD domain-containing ion transport regulator 7 Fxyd7 111.5 124.8 153.6 195.2 181.8 180.7 0.699121391429084 0.0135321515934598 -0.516385116243002 Nonsignificant None 3 Molecular Function:ion channel activity (GO:0005216),Biological Process:ion transport (GO:0006811),Cellular Component:membrane (GO:0016020) FXYD domain-containing ion transport regulator 7 -- -- -- -- -- IPR000272 [Ion-transport regulator, FXYD motif] -- -- Q3V334 Uncharacterized protein Pyy 115.6 109.1 110.5 230.8 272.9 250.9 0.444208852372118 0.000343526829139864 -1.17068995111076 Significant down 2 Molecular Function:hormone activity (GO:0005179),Cellular Component:extracellular region (GO:0005576) peptide YY -- -- -- -- -- IPR001955 [Pancreatic hormone-like] -- -- Q3UCI0 Protein xylosyltransferase Xylt2 37.8 39.5 35.4 38.5 27.4 37.2 1.09311348205626 0.43588051141095 0.128443182804113 Nonsignificant None 4 Biological Process:glycosaminoglycan biosynthetic process (GO:0006024),Molecular Function:acetylglucosaminyltransferase activity (GO:0008375),Cellular Component:membrane (GO:0016020),Molecular Function:protein xylosyltransferase activity (GO:0030158) protein xylosyltransferase 2.4.2.26 ko00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin ko01100 Metabolic pathways Branching enzyme G Carbohydrate transport and metabolism ; IPR003406 [Glycosyl transferase, family 14] ; IPR024448[Xylosyltransferase] -- -- S4R1Q8 Phosphoinositide phospholipase C Plce1 97.6 90.3 83 94.8 90.5 89.3 0.98652585579024 0.799042299975416 -0.0195712319450863 Nonsignificant None 7 Molecular Function:phosphatidylinositol phospholipase C activity (GO:0004435),Molecular Function:guanyl-nucleotide exchange factor activity (GO:0005085),Molecular Function:protein binding (GO:0005515),Biological Process:lipid metabolic process (GO:0006629),Biological Process:signal transduction (GO:0007165),Biological Process:small GTPase mediated signal transduction (GO:0007264),Biological Process:intracellular signal transduction (GO:0035556) phosphatidylinositol phospholipase C, epsilon 3.1.4.11 ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04020 Calcium signaling pathway ko04024 cAMP signaling pathway ko04070 Phosphatidylinositol signaling system ko04919 Thyroid hormone signaling pathway ko04933 AGE-RAGE signaling pathway in diabetic complications ko05205 Proteoglycans in cancer -- -- -- IPR000008 [C2 domain] ; IPR000159[Ras-associating (RA) domain] ; IPR000909[Phosphatidylinositol-specific phospholipase C, X domain] ; IPR001711[Phospholipase C, phosphatidylinositol-specific, Y domain] ; IPR001895[Ras guanine-nucleotide exchange factors catalytic domain] -- -- Q8VDI9 Alpha-1,2-mannosyltransferase ALG9 Alg9 279.8 253.3 247.8 181.7 211.8 210.9 1.29202514890801 0.0135908633390751 0.369634151960439 Nonsignificant None -- -- -- -- ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways Mannosyltransferase MU Cell wall/membrane/envelope biogenesis ; Intracellular trafficking, secretion, and vesicular transport ; IPR005599 [GPI mannosyltransferase] -- -- H3BJB4 RING finger protein 141 Rnf141 255.6 252.1 144.8 196.8 183.6 192.6 1.13874345549738 0.542529187476533 0.187442762700342 Nonsignificant None -- -- -- -- -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; -- -- -- Q99P30 Peroxisomal coenzyme A diphosphatase NUDT7 Nudt7 99 76.7 97.5 106.6 99.9 95.6 0.904336312479311 0.288411713843259 -0.14506870043785 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) peroxisomal coenzyme A diphosphatase NUDT7 3.6.1.- ko04146 Peroxisome Peroxisomal NUDIX hydrolase L Replication, recombination and repair ; IPR000086 [NUDIX hydrolase domain] -- -- A0A0N4SWA5 [F-actin]-monooxygenase MICAL3 (Fragment) Mical3 20 21.3 16.2 27.5 26.7 24.5 0.730622617534943 0.0163406537582999 -0.452801679675749 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:FAD binding (GO:0071949) F-actin monooxygenase 1.14.13.225 -- Regulatory protein MLP and related LIM proteins TZ Signal transduction mechanisms ; Cytoskeleton ; IPR001715 [Calponin homology domain] ; IPR002938[FAD-binding domain] -- -- Q9D1G3 Protein-cysteine N-palmitoyltransferase HHAT-like protein Hhatl 19.3 16.6 19.2 18.5 14.2 18.7 1.07198443579767 0.511440682823767 0.100283959377279 Nonsignificant None -- -- -- -- -- Acyltransferase required for palmitoylation of Hedgehog (Hh) family of secreted signaling proteins T Signal transduction mechanisms ; IPR004299 [Membrane bound O-acyl transferase, MBOAT] -- -- Q3V300 Kinesin-like protein KIF22 Kif22 140.2 152.9 125 137.2 131.6 128.5 1.05235338535112 0.458354840100345 0.0736192499560386 Nonsignificant None 4 Molecular Function:microtubule motor activity (GO:0003777),Molecular Function:ATP binding (GO:0005524),Biological Process:microtubule-based movement (GO:0007018),Molecular Function:microtubule binding (GO:0008017) kinesin family member 22 -- ko04914 Progesterone-mediated oocyte maturation Kinesin-like protein Z Cytoskeleton ; IPR001752 [Kinesin motor domain] -- -- Q9DBT3 Coiled-coil domain-containing protein 97 Ccdc97 159.3 158.1 167.6 118.5 139.7 133.1 1.2394582162024 0.0108141674527872 0.309709637061058 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR018613 [Protein of unknown function DUF2052, coiled-coil] -- -- D3YUR8 Ergosterol biosynthetic protein 28 homolog (Fragment) Erg28 302.4 305.2 273.4 285.1 294 249.4 1.06336753168377 0.361497462517271 0.0886403216989615 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) -- -- -- Predicted membrane protein S Function unknown ; IPR005352 [Erg28] -- -- Q3TX25 Aldehyde dehydrogenase Aldh3b1 154.2 158.3 159.6 138.6 157.9 146.3 1.06616982836495 0.169794258784536 0.092437260822441 Nonsignificant None 3 Biological Process:metabolic process (GO:0008152),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) aldehyde dehydrogenase (NAD(P)+) 1.2.1.5 ko00010 Glycolysis / Gluconeogenesis ko00340 Histidine metabolism ko00350 Tyrosine metabolism ko00360 Phenylalanine metabolism ko00410 beta-Alanine metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko01100 Metabolic pathways ko05204 Chemical carcinogenesis Aldehyde dehydrogenase C Energy production and conversion ; IPR015590 [Aldehyde dehydrogenase domain] -- -- P97406 Envelope protein D17H6S56E-5 424.7 385.5 376.7 337.9 326.6 335.1 1.18737494997999 0.0145674914135516 0.24777558203861 Nonsignificant None -- -- -- -- -- -- -- -- IPR018154 [TLV/ENV coat polyprotein] -- -- Q3V3C0 DNA-directed RNA polymerase (Fragment) Polrmt 92.2 77.9 71.2 59 65.3 70.5 1.23870636550308 0.0921270811958593 0.308834238133409 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Molecular Function:DNA-directed 5'-3' RNA polymerase activity (GO:0003899) DNA-directed RNA polymerase, mitochondrial 2.7.7.6 -- Mitochondrial/chloroplast DNA-directed RNA polymerase RPO41, provides primers for DNA replication-initiation KL Transcription ; Replication, recombination and repair ; IPR002092 [DNA-directed RNA polymerase, phage-type] ; IPR029262[DNA-directed RNA polymerase, N-terminal] -- -- B2RTG1 Thrombospondin, type I, domain containing 4 Thsd4 25.2 24 32.1 26 20.2 25 1.14185393258427 0.337747318626245 0.19137811110863 Nonsignificant None 3 Molecular Function:metalloendopeptidase activity (GO:0004222),Molecular Function:peptidase activity (GO:0008233),Cellular Component:extracellular matrix (GO:0031012) -- -- -- Serine proteinase inhibitor (KU family) with thrombospondin repeats O Posttranslational modification, protein turnover, chaperones ; IPR000884 [Thrombospondin type-1 (TSP1) repeat] ; IPR010294[ADAM-TS Spacer 1] ; IPR010909[PLAC] -- -- Q9JJN5 Carboxypeptidase N catalytic chain Cpn1 87.8 81.8 63.5 41.7 54.1 58.4 1.51167315175097 0.0411894202956646 0.596146239213832 Significant up 3 Molecular Function:metallocarboxypeptidase activity (GO:0004181),Biological Process:proteolysis (GO:0006508),Molecular Function:zinc ion binding (GO:0008270) carboxypeptidase N catalytic subunit 3.4.17.3 -- Zinc carboxypeptidase R General function prediction only ; IPR000834 [Peptidase M14, carboxypeptidase A] -- -- A7E1Z5 Anion exchange protein Slc4a4 183.4 186.4 224.2 175.8 175.9 175.5 1.12670713201821 0.231959102349624 0.172112560680076 Nonsignificant None 3 Biological Process:anion transport (GO:0006820),Molecular Function:anion transmembrane transporter activity (GO:0008509),Cellular Component:integral component of membrane (GO:0016021) solute carrier family 4 (sodium bicarbonate cotransporter), member 4 -- ko04964 Proximal tubule bicarbonate reclamation ko04972 Pancreatic secretion ko04976 Bile secretion Na+-independent Cl/HCO3 exchanger AE1 and related transporters (SLC4 family) P Inorganic ion transport and metabolism ; IPR011531 [Bicarbonate transporter, C-terminal] ; IPR013769[Band 3 cytoplasmic domain] -- -- Q9WV03 Protein FAM50A Fam50a 320 347.9 410.8 388.7 378.9 373.9 0.944984669294788 0.484498329940956 -0.0816371705396746 Nonsignificant None 1 Cellular Component:nucleus (GO:0005634) protein FAM50 -- -- Uncharacterized conserved protein XAP-5 S Function unknown ; IPR007005 [XAP5 protein] -- -- P35330 Intercellular adhesion molecule 2 Icam2 630.5 673.4 729.2 582.1 607.6 554.6 1.16556784956716 0.041145483330653 0.221032988495057 Nonsignificant None -- -- intercellular adhesion molecule 2 -- ko04514 Cell adhesion molecules (CAMs) ko04650 Natural killer cell mediated cytotoxicity -- -- -- IPR013768 [Intercellular adhesion molecule, N-terminal] -- -- P28293 Cathepsin G Ctsg 91 106.2 72.3 42.1 38.3 43.5 2.17514124293785 0.035669907768719 1.12110908549927 Significant up 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) cathepsin G 3.4.21.20 ko04080 Neuroactive ligand-receptor interaction ko04142 Lysosome ko04614 Renin-angiotensin system ko05146 Amoebiasis ko05322 Systemic lupus erythematosus Trypsin E Amino acid transport and metabolism ; IPR001254 [Serine proteases, trypsin domain] -- -- Q8BLY7 BLOC-2 complex member HPS6 Hps6 26.2 25.2 20.9 29.7 24.3 28.4 0.877427184466019 0.21713974452565 -0.188648690232101 Nonsignificant None -- -- Hermansky-Pudlak syndrome 6 protein -- -- -- -- -- IPR017218 [BLOC-2 complex, Hps6 subunit] -- -- A2ALR8 Ubiquitinyl hydrolase 1 (Fragment) Usp48 27.7 26 26.7 27.1 23.4 29.2 1.00878293601004 0.901249376934011 0.012615777188457 Nonsignificant None 2 Biological Process:protein deubiquitination (GO:0016579),Molecular Function:thiol-dependent ubiquitinyl hydrolase activity (GO:0036459) ubiquitin carboxyl-terminal hydrolase 48 3.4.19.12 -- Ubiquitin carboxyl-terminal hydrolase O Posttranslational modification, protein turnover, chaperones ; IPR001394 [Peptidase C19, ubiquitin carboxyl-terminal hydrolase] -- -- Q8CGC4 Protein LSM14 homolog B Lsm14b 36 29.1 33.5 38.9 36.4 38 0.870255957634598 0.084405466909236 -0.200488309442604 Nonsignificant None -- -- protein LSM14 -- -- Uncharacterized mRNA-associated protein RAP55 U Intracellular trafficking, secretion, and vesicular transport ; IPR019050 [FDF domain] ; IPR025609[Lsm14-like, N-terminal] -- -- Q8VCS4 Hepatocyte growth factor activator Hgfac 29 19.7 24.5 31.7 21.5 28.5 0.895960832313341 0.521269918944023 -0.158492429861641 Nonsignificant None 4 Molecular Function:serine-type endopeptidase activity (GO:0004252),Molecular Function:protein binding (GO:0005515),Cellular Component:extracellular region (GO:0005576),Biological Process:proteolysis (GO:0006508) hepatocyte growth factor activator 3.4.21.- -- Fibrillins and related proteins containing Ca2+-binding EGF-like domains T Signal transduction mechanisms ; IPR000001 [Kringle] ; IPR000083[Fibronectin, type I] ; IPR000562[Fibronectin, type II, collagen-binding] ; IPR000742[EGF-like domain] ; IPR001254[Serine proteases, trypsin domain] -- -- O35604 NPC intracellular cholesterol transporter 1 Npc1 325.8 323.8 298.9 301.2 268.1 316.4 1.07090436942531 0.277766614035877 0.0988296547699904 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) Niemann-Pick C1 protein -- ko04142 Lysosome ko04979 Cholesterol metabolism Cholesterol transport protein (Niemann-Pick C disease protein) I Lipid transport and metabolism ; IPR000731 [Sterol-sensing domain] ; IPR003392[Protein patched/dispatched] ; IPR032190[Niemann-Pick C1, N-terminal] -- -- E9Q8K5 Titin Ttn 216.8 224.5 175.3 317.1 347.4 260.5 0.666594594594595 0.0257820800761733 -0.585118476183862 Significant down 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) titin 2.7.11.1 ko05410 Hypertrophic cardiomyopathy (HCM) ko05414 Dilated cardiomyopathy (DCM) Projectin/twitchin and related proteins Z Cytoskeleton ; IPR000719 [Protein kinase domain] ; IPR003961[Fibronectin type III] ; IPR004168[PPAK motif] ; IPR013098[Immunoglobulin I-set] ; IPR015129[Titin, Z repeat] -- -- Q8K2C6 NAD-dependent protein deacylase sirtuin-5, mitochondrial Sirt5 198.7 224.3 221.5 230.6 238.1 236.2 0.914314087104554 0.074932160147932 -0.129238246815375 Nonsignificant None 1 Molecular Function:NAD+ binding (GO:0070403) NAD-dependent deacetylase sirtuin 5 3.5.1.- -- Sirtuin 5 and related class III sirtuins (SIR2 family) BK Chromatin structure and dynamics ; Transcription ; IPR003000 [Sirtuin family] -- -- Q8BSA9 tRNA wybutosine-synthesizing protein 3 homolog Tyw3 71.5 64.1 62.1 75.7 70.8 65.1 0.934310018903592 0.330820867815877 -0.0980267563848177 Nonsignificant None -- -- tRNA wybutosine-synthesizing protein 3 2.1.1.282 -- Uncharacterized conserved protein S Function unknown ; IPR003827 [tRNA wybutosine-synthesizing protein] -- -- Q8R1E1 Lpgat1 protein (Fragment) Lpgat1 150.3 161 301.4 250.3 219 212 0.899310142374872 0.671682362825979 -0.153109355450715 Nonsignificant None -- -- lysophosphatidylglycerol acyltransferase 1 2.3.1.- ko00564 Glycerophospholipid metabolism Lysophosphatidic acid acyltransferase LPAAT and related acyltransferases I Lipid transport and metabolism ; IPR032098 [Acyltransferase, C-terminal domain] -- -- Q9DBQ7 Protein-associating with the carboxyl-terminal domain of ezrin Scyl3 36.3 40.7 43.1 51.5 51.7 46.6 0.80173564753004 0.0189114231948258 -0.318801472753117 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) SCY1-like protein 3 -- -- Protein kinase R General function prediction only ; IPR000719 [Protein kinase domain] -- -- Q9WTZ1 RING-box protein 2 Rnf7 185.7 170.3 197.3 214.7 251 225.7 0.800260341336419 0.025732894253326 -0.321458679819574 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) RING-box protein 2 -- ko04120 Ubiquitin mediated proteolysis SCF ubiquitin ligase, Rbx1 component O Posttranslational modification, protein turnover, chaperones ; IPR024766 [Zinc finger, RING-H2-type] -- -- A2A9I0 Golgi SNAP receptor complex member 2 Gosr2 394.5 388.7 500.1 458.5 447.3 475.9 0.928783382789317 0.427145656869965 -0.10658593424924 Nonsignificant None -- -- golgi SNAP receptor complex member 2 -- ko04130 SNARE interactions in vesicular transport Golgi SNAP receptor complex member U Intracellular trafficking, secretion, and vesicular transport ; -- -- -- Q3TSL0 Uncharacterized protein Wdr33 347.5 395 170.3 222.3 216 235.9 1.35390091960842 0.364662397024768 0.437122164304471 Nonsignificant None -- -- polyadenylation factor subunit 2 -- ko03015 mRNA surveillance pathway Polyadenylation factor I complex, subunit PFS2 A RNA processing and modification ; -- -- -- Q8C538 Uncharacterized protein Tmcc3 249.7 247.9 250.6 204.1 241.8 205.8 1.14807426730091 0.119671200503076 0.199215970934428 Nonsignificant None -- -- -- -- -- Predicted membrane protein S Function unknown ; IPR019394 [Testis-specific protein TEX28/transmembrane and coiled-coil domains protein] -- -- Q9D7J9 Enoyl-CoA hydratase domain-containing protein 3, mitochondrial Echdc3 62.3 58.7 56 69.2 76 61.6 0.855899419729207 0.0939958562333727 -0.224486825344575 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Biological Process:metabolic process (GO:0008152) -- -- -- Enoyl-CoA isomerase I Lipid transport and metabolism ; IPR001753 [Crotonase superfamily] -- -- A0A1B0GRU3 Zinc finger CCCH domain-containing protein 4 Zc3h4 246 276.5 253.9 229.2 233.5 244.7 1.09754028837998 0.0880347544674208 0.134273899012745 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) -- -- -- Polyadenylation factor I complex, subunit, Yth1 (CPSF subunit) A RNA processing and modification ; IPR000571 [Zinc finger, CCCH-type] -- -- Q3UME1 Uncharacterized protein Ents15 201.9 203.3 146.4 156.3 155.7 141.6 1.21604938271605 0.166533536451146 0.282201816571752 Nonsignificant None -- -- -- -- -- -- -- -- IPR027844 [Protein of unknown function DUF4507] -- -- Q3TPZ1 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase Bst1 47.1 59.1 53.3 35 44.7 33.1 1.41400709219858 0.0355578258605432 0.499789356253438 Nonsignificant None 1 Molecular Function:NAD+ nucleosidase activity (GO:0003953) -- -- ko00760 Nicotinate and nicotinamide metabolism ko01100 Metabolic pathways ko04970 Salivary secretion ko04972 Pancreatic secretion -- -- -- IPR003193 [ADP-ribosyl cyclase (CD38/157)] -- -- Q6PDR1 Lipase Lipa 452.7 375.1 364.6 331.7 350 410 1.09224145827608 0.409615811076808 0.127291823428346 Nonsignificant None -- -- lysosomal acid lipase/cholesteryl ester hydrolase 3.1.1.13 ko00100 Steroid biosynthesis ko04142 Lysosome ko04979 Cholesterol metabolism Triglyceride lipase-cholesterol esterase I Lipid transport and metabolism ; IPR000073 [Alpha/beta hydrolase fold-1] -- -- Q9WV81 G protein pathway suppressor 2 Gps2 143.3 150.7 161.6 181.3 169.5 152.1 0.905945516007159 0.190306808337978 -0.142503806370672 Nonsignificant None -- -- G protein pathway suppressor 2 -- ko05166 HTLV-I infection -- -- -- IPR026094 [G protein pathway suppressor 2] -- -- P97477 Aurora kinase A Aurka 64.8 58.8 48.9 37.9 50.4 36.6 1.38110488390713 0.068016142147036 0.465822884944937 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) aurora kinase A 2.7.11.1 ko04114 Oocyte meiosis ko04914 Progesterone-mediated oocyte maturation Serine/threonine protein kinase D Cell cycle control, cell division, chromosome partitioning ; IPR000719 [Protein kinase domain] -- -- Q9CQ45 Neudesin Nenf 187.3 180.9 191.8 197.8 189.3 222.2 0.91908747743312 0.187700912955099 -0.12172591318498 Nonsignificant None -- -- -- -- -- Putative steroid membrane receptor Hpr6.6/25-Dx R General function prediction only ; IPR001199 [Cytochrome b5-like heme/steroid binding domain] -- -- B2RRE7 OTU domain-containing protein 4 Otud4 148 134.6 117.9 124.4 124.6 109.6 1.11684327941997 0.235944009323735 0.159426754427698 Nonsignificant None -- -- OTU domain-containing protein 4 3.4.19.12 -- -- -- -- IPR003323 [OTU domain] -- -- Q8C8N2 Protein SCAI Scai 18.7 22.4 19 25.4 18.6 20.7 0.928902627511592 0.547133728961081 -0.106400721281322 Nonsignificant None 1 Molecular Function:transcription corepressor activity (GO:0003714) -- -- -- -- -- -- IPR022709 [Protein SCAI] -- -- Q8CFA2 Aminomethyltransferase, mitochondrial Amt 46.5 46 46.2 35.4 42.5 52.6 1.06283524904215 0.638891479036779 0.0879179808663558 Nonsignificant None -- -- aminomethyltransferase 2.1.2.10 ko00260 Glycine, serine and threonine metabolism ko00630 Glyoxylate and dicarboxylate metabolism ko00670 One carbon pool by folate ko01100 Metabolic pathways ko01200 Carbon metabolism Aminomethyl transferase E Amino acid transport and metabolism ; IPR006222 [Glycine cleavage T-protein-like, N-terminal] ; IPR013977[Glycine cleavage T-protein, C-terminal barrel domain] -- -- A2AKK5 Acyl-coenzyme A amino acid N-acyltransferase 1 Acnat1 28.3 24.3 54.7 47 32 35.8 0.934668989547038 0.824261893385022 -0.0974725659191659 Nonsignificant None -- -- -- -- -- -- -- -- IPR006862 [Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase] ; IPR014940[BAAT/Acyl-CoA thioester hydrolase C-terminal] -- -- A0A140LI95 Rap1 GTPase-activating protein 2 (Fragment) Rap1gap2 30 24.3 31.3 49.1 31.5 46.9 0.671372549019608 0.0783786088861376 -0.574814545345073 Nonsignificant None -- -- RAP1 GTPase activating protein 2 -- -- Rap1-GTPase-activating protein (Rap1GAP) T Signal transduction mechanisms ; -- -- -- Q3UIZ4 CXXC-type zinc finger protein 1 Cxxc1 155.3 163 147 161.2 170.4 164.4 0.938104838709677 0.12829547845765 -0.0921789335169907 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Molecular Function:protein binding (GO:0005515),Molecular Function:zinc ion binding (GO:0008270) COMPASS component SPP1 -- -- Uncharacterized PHD Zn-finger protein R General function prediction only ; IPR002857 [Zinc finger, CXXC-type] ; IPR019787[Zinc finger, PHD-finger] ; IPR022056[CpG binding protein, C-terminal] -- -- B2LVG5 Cleavage and polyadenylation specificity factor subunit 4 Cpsf4 168.4 136.8 149.5 145.5 136.9 159.1 1.02989807474519 0.715107134615647 0.0425015662087115 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:zinc ion binding (GO:0008270),Molecular Function:metal ion binding (GO:0046872) cleavage and polyadenylation specificity factor subunit 4 -- ko03015 mRNA surveillance pathway ko05164 Influenza A Polyadenylation factor I complex, subunit, Yth1 (CPSF subunit) A RNA processing and modification ; IPR000571 [Zinc finger, CCCH-type] ; IPR001878[Zinc finger, CCHC-type] -- -- Q5PXT3 Survival of motor neuron Smn1 114 98.9 75.6 69.4 60.9 73.3 1.41699410609037 0.0737336867080682 0.50283375745715 Nonsignificant None 4 Molecular Function:RNA binding (GO:0003723),Cellular Component:nucleus (GO:0005634),Cellular Component:cytoplasm (GO:0005737),Biological Process:mRNA processing (GO:0006397) survival motor neuron protein -- ko03013 RNA transport mRNA splicing protein SMN (survival motor neuron) A RNA processing and modification ; IPR010304 [Survival motor neuron] -- -- D3Z1L4 Protein FAM118B (Fragment) Fam118b 78 77.9 60.2 73.9 95.9 71.3 0.896308585649108 0.442716981935319 -0.157932578743019 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- A0A494BBF8 Ribosomal protein S6 kinase beta-2 Rps6kb2 31.6 32.3 36.3 32.8 38.6 35.3 0.939081537019681 0.385902761346294 -0.0906776676292164 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) ribosomal protein S6 kinase beta 2.7.11.1 ko01521 EGFR tyrosine kinase inhibitor resistance ko01522 Endocrine resistance ko04012 ErbB signaling pathway ko04066 HIF-1 signaling pathway ko04140 Autophagy - animal ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04152 AMPK signaling pathway ko04211 Longevity regulating pathway ko04213 Longevity regulating pathway - multiple species ko04350 TGF-beta signaling pathway ko04371 Apelin signaling pathway ko04666 Fc gamma R-mediated phagocytosis ko04910 Insulin signaling pathway ko04931 Insulin resistance ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05212 Pancreatic cancer ko05221 Acute myeloid leukemia ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer ko05231 Choline metabolism in cancer Ribosomal protein S6 kinase and related proteins RT General function prediction only ; Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- A0A1Y7VL44 Tetratricopeptide repeat protein 7B Ttc7b 49.1 45.7 51.7 57.8 57 50.9 0.884127942063971 0.0832458527709423 -0.177672937911842 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) tetratricopeptide repeat protein 7 -- -- Predicted calmodulin-binding protein T Signal transduction mechanisms ; IPR011990 [Tetratricopeptide-like helical domain] ; IPR013105[Tetratricopeptide repeat 2] ; IPR019734[Tetratricopeptide repeat] -- -- E3WH30 Swi5-dependent recombination DNA repair protein 1 homolog Sfr1 135.7 124.4 132.7 151.4 149.8 138 0.894353369763206 0.0459947437275219 -0.161083124690506 Nonsignificant None -- -- -- -- -- -- -- -- IPR018468 [Double-strand recombination repair protein, Mei5-like] -- -- Q8BKS6 Prolyl endopeptidase (Fragment) Prepl 244 201.2 175.3 222.5 205 240 0.929588014981273 0.523446345594349 -0.10533662644456 Nonsignificant None 4 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508),Molecular Function:serine-type peptidase activity (GO:0008236),Molecular Function:serine-type exopeptidase activity (GO:0070008) Predicted serine protease O Posttranslational modification, protein turnover, chaperones ; IPR001375 [Peptidase S9, prolyl oligopeptidase, catalytic domain] ; IPR023302[Peptidase S9A, N-terminal domain] -- -- Q99N50 Synaptotagmin-like protein 2 Sytl2 48.1 47.9 38.7 44 49.7 53.5 0.91508152173913 0.372329052777454 -0.12802782059471 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) synaptotagmin-like protein -- -- Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR000008 [C2 domain] ; IPR011011[Zinc finger, FYVE/PHD-type] -- -- Q8C4U3 Secreted frizzled-related protein 1 Sfrp1 174.8 180.3 179.7 130.5 151.4 156.4 1.22016883413187 0.0166677332065393 0.287080786568698 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) secreted frizzled-related protein 1 -- ko04310 Wnt signaling pathway Smoothened and related G-protein-coupled receptors T Signal transduction mechanisms ; IPR018933 [Netrin module, non-TIMP type] ; IPR020067[Frizzled domain] -- -- A0A0G2JGD2 Protein S100-A4 (Fragment) S100a4 306.7 383.4 277 266.8 290.5 256.5 1.18837552224134 0.199230439481931 0.24899079444557 Nonsignificant None -- -- -- -- -- -- -- -- IPR013787 [S100/CaBP-9k-type, calcium binding, subdomain] -- -- V9TP20 Cytochrome b (Fragment) cytb 385.5 433.7 454.4 462 423.8 458.5 0.947407572714424 0.377679702015209 -0.0779428913300128 Nonsignificant None 3 Molecular Function:electron carrier activity (GO:0009055),Cellular Component:membrane (GO:0016020),Molecular Function:oxidoreductase activity (GO:0016491) ubiquinol-cytochrome c reductase cytochrome b subunit -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04260 Cardiac muscle contraction ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Cytochrome b C Energy production and conversion ; IPR005797 [Cytochrome b/b6, N-terminal] ; IPR005798[Cytochrome b/b6, C-terminal] -- -- Q91VC9 Growth hormone-inducible transmembrane protein Ghitm 421.2 360 388.8 392.4 351.3 428.7 0.997952917093142 0.978952118748361 -0.00295634333141221 Nonsignificant None -- -- growth hormone-inducible transmembrane protein -- -- Growth hormone-induced protein and related proteins T Signal transduction mechanisms ; IPR006214 [Bax inhibitor 1-related] -- -- Q9Z1Y4 Thyroid receptor-interacting protein 6 Trip6 197.2 216.4 246.7 243.8 248.4 218 0.929738101943115 0.389196456139265 -0.105103714408258 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) thyroid receptor-interacting protein 6 -- ko04621 NOD-like receptor signaling pathway Focal adhesion adaptor protein Paxillin and related LIM proteins T Signal transduction mechanisms ; IPR001781 [Zinc finger, LIM-type] -- -- K4DI63 Protein CREG1 Creg1 68.7 67.9 61.5 60.6 68.3 69.5 0.998487903225806 0.979174476687986 -0.00218314549738872 Nonsignificant None -- -- -- -- -- Cellular repressor of transcription K Transcription ; -- -- -- Q8CBR1 Immunoglobulin-like domain-containing receptor 1 Ildr1 52.9 56.1 57.4 65.7 66.4 53.6 0.896068928379106 0.214508890228843 -0.158318381794329 Nonsignificant None -- -- -- -- -- -- -- -- IPR008664 [LISCH7] -- -- B9EIX2 AW555464 protein Cep170b 111.8 126.3 109.9 122.5 120 113.2 0.978352544278887 0.684869898829789 -0.0315736683257596 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) centrosomal protein CEP170 -- -- -- -- -- IPR000253 [Forkhead-associated (FHA) domain] ; IPR029300[CEP170, C-terminal] -- -- Q8BMI3 ADP-ribosylation factor-binding protein GGA3 Gga3 50.6 58 50.6 63.3 68.8 68.2 0.794807788317524 0.0105227057958051 -0.331322085269059 Nonsignificant None 4 Cellular Component:intracellular (GO:0005622),Biological Process:intracellular protein transport (GO:0006886),Biological Process:vesicle-mediated transport (GO:0016192),Cellular Component:clathrin adaptor complex (GO:0030131) ADP-ribosylation factor-binding protein GGA -- ko04142 Lysosome Cytosolic sorting protein GGA2/TOM1 U Intracellular trafficking, secretion, and vesicular transport ; IPR002014 [VHS domain] ; IPR004152[GAT domain] ; IPR008152[Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain] -- -- A0A0G2JFY6 AP complex subunit beta Ap4b1 74.6 65.3 72 85.5 76.9 77.4 0.883653044203503 0.0771045859928585 -0.178448071042054 Nonsignificant None 4 Biological Process:intracellular protein transport (GO:0006886),Biological Process:vesicle-mediated transport (GO:0016192),Cellular Component:membrane coat (GO:0030117),Cellular Component:clathrin adaptor complex (GO:0030131) AP-4 complex subunit beta-1 -- ko04142 Lysosome Vesicle coat complex AP-1/AP-2/AP-4, beta subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR002553 [Clathrin/coatomer adaptor, adaptin-like, N-terminal] ; IPR015151[Beta-adaptin appendage, C-terminal subdomain] -- -- Q6NSU3 Glycosyltransferase 8 domain-containing protein 1 Glt8d1 39 36 36 35.4 26.5 35 1.14551083591331 0.200504646310895 0.195991105822387 Nonsignificant None -- -- -- -- -- -- -- -- IPR002495 [Glycosyl transferase, family 8] -- -- O70326 Gremlin-1 Grem1 80.8 83.9 77.5 80 79.3 73.1 1.0421686746988 0.318200884469633 0.0595887962898 Nonsignificant None -- -- -- -- -- -- -- -- IPR004133 [DAN] -- -- Q61624 Zinc finger protein 148 Znf148 147.2 126.6 131.6 143.7 124.6 150.3 0.968466316292403 0.679490594168804 -0.0462262227888103 Nonsignificant None -- -- -- -- -- FOG: Zn-finger R General function prediction only ; -- -- zf-C2H2 A0A6M8TZJ8 ATP synthase subunit a ATP6 15.1 23.1 53.6 52.3 46.4 44 0.643307638402243 0.229839149315588 -0.636419276061955 Nonsignificant None 2 Molecular Function:hydrogen ion transmembrane transporter activity (GO:0015078),Biological Process:ATP synthesis coupled proton transport (GO:0015986) F-type H+-transporting ATPase subunit a -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease ATP synthase F0 subunit 6 and related proteins C Energy production and conversion ; IPR000568 [ATP synthase, F0 complex, subunit A] -- -- Q9DB10 Essential MCU regulator, mitochondrial Smdt1 670.9 627 670.9 646.8 665.5 711.2 0.972967630343464 0.491138611920254 -0.0395362860986264 Nonsignificant None 3 Biological Process:mitochondrial calcium uptake (GO:0036444),Biological Process:mitochondrial calcium ion homeostasis (GO:0051560),Cellular Component:uniplex complex (GO:1990246) -- -- -- Predicted membrane protein S Function unknown ; IPR018782 [Essential MCU regulator, mitochondrial] -- -- E9QNY3 Myosin regulatory light chain 10 Myl10 143.5 143.4 140.7 153.7 161.7 169.7 0.881467738610596 0.0152199226713228 -0.182020326474327 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) myosin regulatory light chain 10 -- ko04510 Focal adhesion ko04670 Leukocyte transendothelial migration ko04810 Regulation of actin cytoskeleton Myosin regulatory light chain, EF-Hand protein superfamily Z Cytoskeleton ; IPR002048 [EF-hand domain] -- -- D3Z118 Islet cell autoantigen 1 Ica1 45.8 45.2 68.4 70 61.6 79.4 0.755450236966825 0.135052096973664 -0.404591369604076 Nonsignificant None 1 Molecular Function:protein domain specific binding (GO:0019904) islet cell auto antigen 1 -- ko04940 Type I diabetes mellitus Secretory vesicle-associated protein ICA69, contains Arfaptin domain TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR006723 [Islet cell autoantigen Ica1, C-terminal] ; IPR010504[Arfaptin homology (AH) domain] -- -- E9QNQ2 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B Ankrd44 381.9 397.4 466.5 374.9 386.8 414.6 1.05908356711723 0.462506295355876 0.0828164298486747 Nonsignificant None -- -- serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B -- -- FOG: Ankyrin repeat R General function prediction only ; IPR020683 [Ankyrin repeat-containing domain] -- -- A0A494BBB6 Ribonuclease H2 subunit C (Fragment) Rnaseh2c 185 180.8 159.9 190.5 184.2 183.6 0.941608454236074 0.249343197643382 -0.0868008212084317 Nonsignificant None 2 Biological Process:RNA catabolic process (GO:0006401),Cellular Component:ribonuclease H2 complex (GO:0032299) ribonuclease H2 subunit C -- ko03030 DNA replication -- -- -- IPR013924 [Ribonuclease H2, subunit C] -- -- Q9DCC8 Mitochondrial import receptor subunit TOM20 homolog Tomm20 276.3 271.1 406.9 294.1 287.8 290.1 1.09438073394495 0.599935627463544 0.130114737596381 Nonsignificant None 3 Cellular Component:mitochondrial outer membrane translocase complex (GO:0005742),Biological Process:protein targeting (GO:0006605),Biological Process:intracellular protein transport (GO:0006886) mitochondrial import receptor subunit TOM20 -- -- Translocase of outer mitochondrial membrane complex, subunit TOM20 U Intracellular trafficking, secretion, and vesicular transport ; IPR002056 [Protein import receptor MAS20] -- -- B2RWB7 9630033F20Rik protein Tigar 238.1 258.1 400.6 339.9 334.5 332.4 0.890742947953914 0.54804732782304 -0.166918938355552 Nonsignificant None -- -- fructose-2,6-bisphosphatase 3.1.3.46 ko00051 Fructose and mannose metabolism ko05230 Central carbon metabolism in cancer Phosphoglycerate mutase G Carbohydrate transport and metabolism ; IPR013078 [Histidine phosphatase superfamily, clade-1] -- -- Q9Z0S5 Claudin-15 Cldn15 299 267.5 314 267.2 225.8 297 1.11455696202532 0.290329775426955 0.156470350766743 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) claudin -- ko04514 Cell adhesion molecules (CAMs) ko04530 Tight junction ko04670 Leukocyte transendothelial migration ko05160 Hepatitis C -- -- -- IPR004031 [PMP-22/EMP/MP20/Claudin superfamily] -- -- Q5SSK3 Transcription elongation factor, mitochondrial Tefm 29.5 24.6 34.3 29.7 29.4 27 1.0267131242741 0.806352849745311 0.0380331319945876 Nonsignificant None -- -- transcription elongation factor, mitochondrial -- -- -- -- -- -- -- -- Q9CZ83 39S ribosomal protein L55, mitochondrial Mrpl55 183.2 167.4 176.4 199.9 196.3 176.8 0.919720767888307 0.145948340262693 -0.12073217711969 Nonsignificant None -- -- large subunit ribosomal protein L55 -- -- Mitochondrial ribosomal protein L55 J Translation, ribosomal structure and biogenesis ; IPR018615 [Ribosomal protein L55, mitochondrial] -- -- Q8CG46 Structural maintenance of chromosomes protein 5 Smc5 27.4 22.2 25 28.3 31.8 36.1 0.775467775467775 0.0565928145906646 -0.366861263514804 Nonsignificant None -- -- -- -- -- Structural maintenance of chromosome protein SMC5/Spr18, SMC superfamily BDL Chromatin structure and dynamics ; Cell cycle control, cell division, chromosome partitioning ; Replication, recombination and repair ; IPR003395 [RecF/RecN/SMC, N-terminal] -- -- Q5I043 Ubiquitin carboxyl-terminal hydrolase 28 Usp28 41 36.4 41.8 44.4 46.4 44.5 0.8810051736881 0.0409467693171542 -0.182777603514376 Nonsignificant None 2 Biological Process:protein deubiquitination (GO:0016579),Molecular Function:thiol-dependent ubiquitinyl hydrolase activity (GO:0036459) ubiquitin carboxyl-terminal hydrolase 28 3.4.19.12 -- Ubiquitin carboxyl-terminal hydrolase O Posttranslational modification, protein turnover, chaperones ; IPR001394 [Peptidase C19, ubiquitin carboxyl-terminal hydrolase] -- -- Q14CH7 Alanine--tRNA ligase, mitochondrial Aars2 221.7 243.3 223.9 267 269.6 240.1 0.886957641302948 0.0660995866755435 -0.173062887927418 Nonsignificant None 5 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:alanine-tRNA ligase activity (GO:0004813),Molecular Function:ATP binding (GO:0005524),Biological Process:alanyl-tRNA aminoacylation (GO:0006419),Biological Process:tRNA aminoacylation (GO:0043039) alanyl-tRNA synthetase 6.1.1.7 ko00970 Aminoacyl-tRNA biosynthesis Alanyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR012947 [Threonyl/alanyl tRNA synthetase, SAD] ; IPR018164[Alanyl-tRNA synthetase, class IIc, N-terminal] -- -- Q9QWX2 Bcl-2-like protein 1 (Fragment) Bcl2l1 86.8 76.7 76.4 71 69.9 88.2 1.04714098646879 0.626513149693413 0.0664556989887594 Nonsignificant None 1 Biological Process:regulation of apoptotic process (GO:0042981) Bcl-2-like 1 (apoptosis regulator Bcl-X) -- ko01521 EGFR tyrosine kinase inhibitor resistance ko01524 Platinum drug resistance ko04014 Ras signaling pathway ko04064 NF-kappa B signaling pathway ko04137 Mitophagy - animal ko04140 Autophagy - animal ko04151 PI3K-Akt signaling pathway ko04210 Apoptosis ko04215 Apoptosis - multiple species ko04621 NOD-like receptor signaling pathway ko04630 Jak-STAT signaling pathway ko05014 Amyotrophic lateral sclerosis (ALS) ko05145 Toxoplasmosis ko05166 HTLV-I infection ko05200 Pathways in cancer ko05202 Transcriptional misregulation in cancer ko05212 Pancreatic cancer ko05220 Chronic myeloid leukemia ko05222 Small cell lung cancer ko05225 Hepatocellular carcinoma Anti-apoptotic Bcl-2 family proteins, prevent opening of mitochondrial porin channel T Signal transduction mechanisms ; IPR003093 [Apoptosis regulator, Bcl-2 protein, BH4] ; IPR026298[Blc2 family] -- -- A0A1S6GWJ6 NOT2_3_5 domain-containing protein Cnot2 168.5 162.1 151.9 170.6 174.1 161.5 0.953180561043066 0.266370447164995 -0.0691785650678788 Nonsignificant None 1 Cellular Component:nucleus (GO:0005634) CCR4-NOT transcription complex subunit 2 -- ko03018 RNA degradation Predicted transcriptional regulator KDR Transcription ; Cell cycle control, cell division, chromosome partitioning ; General function prediction only ; IPR007282 [NOT2/NOT3/NOT5] -- -- Q9CQX4 PCNA-associated factor Pclaf 76.1 78.3 75.8 79 80.8 68.3 1.00920648838229 0.868941138088559 0.013221386820093 Nonsignificant None 2 Biological Process:cellular response to DNA damage stimulus (GO:0006974),Biological Process:regulation of cell cycle (GO:0051726) -- -- -- -- -- -- IPR031444 [PCNA-associated factor] -- -- Q569Y3 Zinc finger, HIT domain containing 2 Znhit2 104.6 109.5 101.4 78.2 107.6 101.6 1.09777313848295 0.369584346698475 0.134579943412575 Nonsignificant None -- -- -- -- -- Predicted Zn-finger protein S Function unknown ; IPR007529 [Zinc finger, HIT-type] -- -- A2AEC2 Transcription elongation factor A protein-like 3 (Fragment) Tceal3 95.6 98.4 88.5 135.8 131 118.8 0.732624481327801 0.00420847589128763 -0.448854184040049 Nonsignificant None -- -- -- -- -- -- -- -- IPR021156 [Transcription elongation factor A-like/Brain expressed X-linked] -- -- O55091 Protein IMPACT Impact 24.2 29.8 28.6 26.5 26.3 31.8 0.976359338061466 0.801220099444119 -0.0345158817005043 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR001498 [Impact, N-terminal] ; IPR006575[RWD domain] -- -- Q91VL8 Telomeric repeat-binding factor 2-interacting protein 1 Terf2ip 327.3 330.4 414.9 357.2 404.8 357.7 0.957935161203894 0.656709411762156 -0.0620000858729743 Nonsignificant None -- -- telomeric repeat-binding factor 2-interacting protein 1 -- -- -- -- -- IPR001357 [BRCT domain] ; IPR015010[Rap1 Myb domain] ; IPR021661[TRF2-interacting telomeric protein/Rap1, C-terminal] -- -- E9Q411 Neuroblastoma-amplified sequence Nbas 221.8 199.6 214.3 190.9 220.4 211 1.02153302265788 0.702257645749273 0.0307358422059518 Nonsignificant None -- -- neuroblastoma-amplified sequence -- -- Uncharacterized conserved protein (Neuroblastoma-amplified protein) S Function unknown ; IPR013244 [Sec39 domain] ; IPR029145[Neuroblastoma-amplified sequence, N-terminal] -- -- A0A140LHA0 Proline-rich AKT1 substrate 1 (Fragment) Akt1s1 71.2 73.5 54.1 40.5 51.9 53.6 1.36164383561644 0.0754079144485919 0.445349387794907 Nonsignificant None 2 Biological Process:negative regulation of TOR signaling (GO:0032007),Biological Process:neurotrophin TRK receptor signaling pathway (GO:0048011) proline-rich AKT1 substrate 1 -- ko04140 Autophagy - animal ko04150 mTOR signaling pathway ko04152 AMPK signaling pathway ko04211 Longevity regulating pathway ko04213 Longevity regulating pathway - multiple species -- -- -- IPR026682 [Proline-rich AKT1 substrate 1 protein] -- -- B7ZN55 Neutral ceramidase Asah2 330.9 319.1 365.1 432.7 446.6 479.6 0.747001251011848 0.00425815988632101 -0.420817435772344 Nonsignificant None -- -- neutral ceramidase 3.5.1.23 ko00600 Sphingolipid metabolism ko01100 Metabolic pathways ko04071 Sphingolipid signaling pathway Ceramidases T Signal transduction mechanisms ; IPR031329 [Neutral/alkaline non-lysosomal ceramidase, N-terminal] ; IPR031331[Neutral/alkaline non-lysosomal ceramidase, C-terminal] -- -- Q3TSP0 Uncharacterized protein Pcmtd1 21.9 19.1 20.6 28.7 18.4 25.9 0.843835616438356 0.298033180688253 -0.244966113072478 Nonsignificant None -- -- -- -- -- Protein-L-isoaspartate(D-aspartate) O-methyltransferase O Posttranslational modification, protein turnover, chaperones ; -- -- -- E9QKG3 tRNA (guanine(10)-N2)-methyltransferase homolog Trmt11 147.9 145 155.8 186.2 160.1 183.8 0.84644406715714 0.0384890834818182 -0.240513356596428 Nonsignificant None -- -- tRNA (guanine10-N2)-methyltransferase 2.1.1.214 -- Putative RNA methylase L Replication, recombination and repair ; IPR000241 [Putative RNA methylase domain] -- -- Q9JIG8 PRA1 family protein 2 Praf2 173.6 183.4 212.7 198.2 186 184.2 1.00228712174525 0.974093456149107 0.00329585162787332 Nonsignificant None -- -- PRA1 family protein 2 -- -- Glutamate transporter EAAC1-interacting protein GTRAP3-18 ET Amino acid transport and metabolism ; Signal transduction mechanisms ; IPR004895 [Prenylated rab acceptor PRA1] -- -- Q8C0Y2 Aldolase_II domain-containing protein (Fragment) Add2 103.2 88.4 109.4 138.8 147.2 126.1 0.730405241446251 0.0133022430655193 -0.453230976633435 Nonsignificant None -- -- adducin -- -- Cytoskeletal protein Adducin TZ Signal transduction mechanisms ; Cytoskeleton ; IPR001303 [Class II aldolase/adducin N-terminal] -- -- Q8BK75 Elongator complex protein 6 Elp6 215.6 185.9 170.1 159.4 163.6 187.6 1.11946729338034 0.271907393118961 0.162812378688698 Nonsignificant None 1 Cellular Component:Elongator holoenzyme complex (GO:0033588) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR018627 [Elongation complex protein 6] -- -- Q3ULB0 RNA-binding motif protein 6 Rbm6 146.6 153.2 161 149.8 194.3 158.2 0.917380051761895 0.387262945054384 -0.124408558229517 Nonsignificant None -- -- -- -- -- RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains R General function prediction only ; -- -- -- A0A571BEV7 Palmitoyltransferase Zdhhc3 141.6 140.2 127.2 111.1 114.8 125.2 1.16491028197095 0.0363216328027699 0.220218846948356 Nonsignificant None -- -- palmitoyltransferase ZDHHC3/7/25 2.3.1.225 -- DHHC-type Zn-finger proteins R General function prediction only ; IPR001594 [Palmitoyltransferase, DHHC domain] -- -- Q9D8T7 SRA stem-loop-interacting RNA-binding protein, mitochondrial Slirp 232.2 227.5 242.9 248.1 273.1 223.7 0.943213854208618 0.399616166830046 -0.084343185675626 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- FOG: RRM domain R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- Q78T54 Vacuolar ATPase assembly integral membrane protein Vma21 Vma21 106.9 124.7 182.4 165.9 194.3 203.1 0.734954731049174 0.121665564124753 -0.444272703852861 Nonsignificant None 1 Biological Process:vacuolar proton-transporting V-type ATPase complex assembly (GO:0070072) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019013 [Vacuolar ATPase assembly integral membrane protein Vma21] -- -- A0A0R4J175 Bromodomain-containing protein 9 Brd9 203.3 211.7 119.5 117 113.9 127.4 1.49176667596986 0.181993286543395 0.577021904397117 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) bromodomain-containing protein 9 -- -- IRF-2-binding protein CELTIX-1, contains BROMO domain K Transcription ; IPR001487 [Bromodomain] ; IPR021900[Protein of unknown function DUF3512] -- -- Q8CBY0 Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial Gatc 17.9 27.4 29.4 26.5 31.3 26.9 0.881936245572609 0.437218345032677 -0.181253726542962 Nonsignificant None 1 Biological Process:regulation of translational fidelity (GO:0006450) -- -- ko00970 Aminoacyl-tRNA biosynthesis ko01100 Metabolic pathways Mitochondrial DNA polymerase accessory subunit L Replication, recombination and repair ; IPR003837 [Glu-tRNAGln amidotransferase C subunit] -- -- Q80UK0 SEC14 domain and spectrin repeat-containing protein 1 Sestd1 89.1 79.8 90.4 102.6 103.2 101.3 0.844350374470856 0.00925619625448624 -0.24408630612258 Nonsignificant None -- -- -- -- -- Multidomain protein, contains SPEC repeats, PH, SH3, and separate rac-specific and rho-specific guanine nucleotide exchange factor domains T Signal transduction mechanisms ; IPR001251 [CRAL-TRIO lipid binding domain] -- -- D3Z479 Sorting nexin-15 Snx15 137.4 118.3 141.8 153.9 143 152.4 0.884709548186067 0.0964421602112734 -0.176724201464358 Nonsignificant None 1 Molecular Function:phosphatidylinositol binding (GO:0035091) sorting nexin-15 -- -- Intermediate filament-like protein, sorting nexins, and related proteins containing PX (PhoX) domain(s) ZUD Cytoskeleton ; Intracellular trafficking, secretion, and vesicular transport ; Cell cycle control, cell division, chromosome partitioning ; IPR001683 [Phox homologous domain] -- -- Q8CI08 SLAIN motif-containing protein 2 Slain2 232.2 199.7 181.3 176.7 180.9 182.2 1.13597628751389 0.240857545861371 0.183932720191926 Nonsignificant None -- -- SLAIN motif-containing protein 1/2 -- -- -- -- -- IPR026179 [SLAIN motif-containing protein] -- -- Q99K95 Replication termination factor 2 Rtf2 118.4 121 125.8 82.8 90.7 106.3 1.30521801286633 0.0170482239844158 0.384290802819469 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR027799 [Replication termination factor 2, RING-finger] -- -- Q3UDK1 TRAF-type zinc finger domain-containing protein 1 Trafd1 41.9 34.4 57.7 63.3 70.3 79 0.630291627469426 0.033455981763442 -0.66590859618597 Significant down -- -- -- -- -- -- -- -- -- -- -- G3UVU6 Mediator of RNA polymerase II transcription subunit 20 Gm20517 101.5 95.4 105.8 112.6 108.4 107.5 0.921461187214612 0.0648055575916971 -0.118004695382178 Nonsignificant None 3 Molecular Function:RNA polymerase II transcription cofactor activity (GO:0001104),Biological Process:regulation of transcription from RNA polymerase II promoter (GO:0006357),Cellular Component:mediator complex (GO:0016592) mediator of RNA polymerase II transcription subunit 20 -- -- Transcription mediator-related factor K Transcription ; IPR013921 [Mediator complex, subunit Med20] -- -- Q504N0 Carboxypeptidase A2 Cpa2 114.8 91.2 85.2 77.9 98.6 87.5 1.1030303030303 0.449770991504655 0.14147242595288 Nonsignificant None 4 Molecular Function:carboxypeptidase activity (GO:0004180),Molecular Function:metallocarboxypeptidase activity (GO:0004181),Biological Process:proteolysis (GO:0006508),Molecular Function:zinc ion binding (GO:0008270) carboxypeptidase A2 3.4.17.15 ko04972 Pancreatic secretion ko04974 Protein digestion and absorption Zinc carboxypeptidase S Function unknown ; IPR000834 [Peptidase M14, carboxypeptidase A] ; IPR003146[Carboxypeptidase, activation peptide] -- -- A2ADA5 tRNA pseudouridine synthase-like 1 Pusl1 74.5 57.4 93.4 95 107.6 131.9 0.673542600896861 0.072392113752719 -0.570158897293396 Nonsignificant None 4 Biological Process:pseudouridine synthesis (GO:0001522),Molecular Function:RNA binding (GO:0003723),Biological Process:RNA modification (GO:0009451),Molecular Function:pseudouridine synthase activity (GO:0009982) -- -- -- Predicted pseudouridylate synthase AJ RNA processing and modification ; Translation, ribosomal structure and biogenesis ; IPR020097 [Pseudouridine synthase I, TruA, alpha/beta domain] -- -- A2A484 Zinc finger, MYND-type-containing 8 Zmynd8 227.1 225.2 232.7 215.3 216.2 219.2 1.05271246350085 0.0108295251789968 0.0741114343418211 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- PHD Zn-finger protein R General function prediction only ; IPR000313 [PWWP domain] ; IPR001487[Bromodomain] ; IPR021931[Protein of unknown function DUF3544] -- -- Q80VP5 Mitochondrial translation release factor in rescue Mtrfr 23.5 33.9 37.6 24.8 33.5 24.2 1.15151515151515 0.466359947753324 0.203533394085132 Nonsignificant None 2 Molecular Function:translation release factor activity (GO:0003747),Biological Process:translational termination (GO:0006415) -- -- -- Mitochondrial polypeptide chain release factor J Translation, ribosomal structure and biogenesis ; IPR000352 [Peptide chain release factor class I/class II] -- -- Q3U2M0 Uncharacterized protein (Fragment) Fam126a 39 38 49.7 53.9 67.7 52.3 0.728579643473261 0.0629699356548255 -0.456841408165778 Nonsignificant None -- -- protein FAM126 -- -- Putative beta-catenin-Tcf/Lef signaling pathway component DRCTNNB1A T Signal transduction mechanisms ; IPR018619 [Hyccin] -- -- Q9JME7 Trafficking protein particle complex subunit 2-like protein Trappc2l 487.9 436.4 441.3 435.6 428.4 446.4 1.04212454212454 0.345591348610032 0.0595277013867293 Nonsignificant None 2 Cellular Component:intracellular (GO:0005622),Biological Process:ER to Golgi vesicle-mediated transport (GO:0006888) trafficking protein particle complex subunit 2 -- -- Uncharacterized conserved protein S Function unknown ; IPR006722 [Trafficking protein particle complex subunit 2] -- -- O35098 Dihydropyrimidinase-related protein 4 Dpysl4 66.2 84 89.6 106.9 115 93.2 0.761028245001587 0.0574439885370261 -0.393978095603316 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) -- -- -- Dihydroorotase and related enzymes F Nucleotide transport and metabolism ; IPR006680 [Amidohydrolase-related] -- -- A0A1Y7VLP0 ATP synthase membrane subunit 6.8PL (Fragment) Atp5mpl 579.8 475.9 546.8 591.9 609.6 702.5 0.841649159663866 0.0942367575257027 -0.24870912180184 Nonsignificant None 1 Cellular Component:mitochondrion (GO:0005739) 6.8 kDa mitochondrial proteolipid -- -- -- -- -- IPR012574 [Mitochondrial proteolipid] -- -- Q9QZD4 DNA repair endonuclease XPF Ercc4 13.4 13.7 14.8 13.6 15.6 17.1 0.904967602591793 0.253105035230369 -0.144061949560885 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Molecular Function:nuclease activity (GO:0004518) DNA excision repair protein ERCC-4 3.1.-.- ko03420 Nucleotide excision repair ko03460 Fanconi anemia pathway Structure-specific endonuclease ERCC1-XPF, catalytic component XPF/ERCC4 L Replication, recombination and repair ; IPR006166 [ERCC4 domain] -- -- Q8BJ34 Meiosis regulator and mRNA stability factor 1 Marf1 7.2 7.6 9.3 12.8 8.1 12 0.732522796352584 0.138468121430621 -0.44905443750528 Nonsignificant None -- -- meiosis arrest female protein 1 -- -- -- -- -- IPR021139 [NYN domain, limkain-b1-type] ; IPR024582[Marf1, conserved domain] ; IPR025605[OST-HTH/LOTUS domain] -- -- P0C7N9 Proteasome assembly chaperone 4 Psmg4 9.5 16 16.5 14.5 14.2 13.7 0.990566037735849 0.958341802070112 -0.0136749368970765 Nonsignificant None 1 Biological Process:proteasome assembly (GO:0043248) proteasome assembly chaperone 4 -- -- -- -- -- IPR032157 [Proteasome assembly chaperone 4] -- -- Q8C0M0 GATOR complex protein WDR59 Wdr59 183.2 167.4 170.3 198.8 177.6 182.2 0.932509846043681 0.194165764666886 -0.100809136529247 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) WD repeat-containing protein 59 -- ko04150 mTOR signaling pathway Conserved WD40 repeat-containing protein S Function unknown ; IPR001680 [WD40 repeat] -- -- Q9CQ88 Tetraspanin-31 Tspan31 35.8 33.5 34.1 47.6 41.2 37.6 0.818037974683544 0.0631756543975568 -0.289760277862168 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) tetraspanin-13/31 -- -- Tetraspanin family integral membrane protein R General function prediction only ; IPR018499 [Tetraspanin/Peripherin] -- -- A0A2S0DFH5 Anti-HIV fusion peptide monocolonal anitbody light chain vFP5.01 (Fragment) 138.5 193.6 177.2 109.9 120 115.1 1.47623188405797 0.0299152548967518 0.56191935534464 Nonsignificant None -- -- pre-B lymphocyte gene -- -- -- -- -- IPR013106 [Immunoglobulin V-set domain] -- -- Q8BM85 TBC domain-containing protein kinase-like protein Tbck 59.5 46.5 44.5 53.7 54.3 52.8 0.935945273631841 0.541678286523709 -0.0955039195318643 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) TBC domain-containing protein kinase-like protein -- -- Predicted protein kinase (contains TBC and RHOD domains) R General function prediction only ; IPR000195 [Rab-GTPase-TBC domain] ; IPR000719[Protein kinase domain] -- -- D6RG56 Lysine-specific demethylase 9 (Fragment) Rsbn1 113.8 139.8 94.8 109.7 137.8 124 0.937819650067295 0.642483732189225 -0.092617586827094 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; -- -- -- Q9QZM0 Ubiquilin-2 Ubqln2 82.8 69.5 59.1 64.7 71.2 66.7 1.04343534057256 0.701584661869864 0.0613412025815448 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) ubiquilin -- ko04141 Protein processing in endoplasmic reticulum Ubiquitin-like protein OR Posttranslational modification, protein turnover, chaperones ; General function prediction only ; IPR000626 [Ubiquitin domain] ; IPR015940[Ubiquitin-associated domain] -- -- Q9JHF7 Hematopoietic prostaglandin D synthase Hpgds 299.9 281.9 202.2 180.5 212.5 217.2 1.28482464765651 0.145978831134232 0.361571474423914 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- ko00480 Glutathione metabolism ko00590 Arachidonic acid metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko01100 Metabolic pathways ko05204 Chemical carcinogenesis Glutathione S-transferase O Posttranslational modification, protein turnover, chaperones ; IPR004045 [Glutathione S-transferase, N-terminal] ; IPR004046[Glutathione S-transferase, C-terminal] -- -- Q91YL3 Uridine-cytidine kinase-like 1 Uckl1 77.4 65.7 69.8 111.1 98.8 102.7 0.681062060140755 0.00264375564977009 -0.55414182854737 Nonsignificant None 3 Molecular Function:ATP binding (GO:0005524),Biological Process:metabolic process (GO:0008152),Molecular Function:kinase activity (GO:0016301) uridine kinase 2.7.1.48 ko00240 Pyrimidine metabolism ko00983 Drug metabolism - other enzymes ko01100 Metabolic pathways Armadillo/beta-Catenin/plakoglobin TZ Signal transduction mechanisms ; Cytoskeleton ; IPR006083 [Phosphoribulokinase/uridine kinase] ; IPR029057[Phosphoribosyltransferase-like] -- -- Q3TPL8 Solute carrier family 2, facilitated glucose transporter member 3 Slc2a3 89.2 116.3 111.6 90.4 96.6 83.2 1.17357512953368 0.164986619071612 0.230910202778155 Nonsignificant None 3 Cellular Component:integral component of membrane (GO:0016021),Molecular Function:transmembrane transporter activity (GO:0022857),Biological Process:transmembrane transport (GO:0055085) MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 3 -- -- Permease of the major facilitator superfamily G Carbohydrate transport and metabolism ; IPR005828 [Major facilitator, sugar transporter-like] -- -- A0A1W2P7K6 Rab-3A-interacting protein Rab3ip 81.7 77.8 78.6 83.6 74.7 86.7 0.971836734693877 0.576509558189364 -0.041214128619599 Nonsignificant None -- -- Rab-3A-interacting protein -- -- Guanine nucleotide exchange factor U Intracellular trafficking, secretion, and vesicular transport ; IPR009449 [GDP/GTP exchange factor Sec2, N-terminal] -- -- Q9D291 Deubiquitinase DESI2 Desi2 173.8 163.3 180.8 192.5 199.8 206.2 0.865329991645781 0.014039271282357 -0.208677688700016 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR008580 [PPPDE putative peptidase domain] -- -- Q8VHZ7 U3 small nucleolar ribonucleoprotein protein IMP4 Imp4 151.8 152.2 126.9 127.6 119.2 119.7 1.17571623465211 0.0712253889005761 0.233539900089208 Nonsignificant None -- -- U3 small nucleolar ribonucleoprotein protein IMP4 -- ko03008 Ribosome biogenesis in eukaryotes U3 small nucleolar ribonucleoprotein (snoRNP) component A RNA processing and modification ; IPR007109 [Brix domain] -- -- Q3UJV6 Uncharacterized protein Uqcr11 114.8 106.5 114.3 134.5 120.9 142.7 0.843004270283848 0.0392191406710106 -0.246388155651526 Nonsignificant None 2 Molecular Function:ubiquinol-cytochrome-c reductase activity (GO:0008121),Molecular Function:electron carrier activity (GO:0009055) ubiquinol-cytochrome c reductase subunit 10 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04260 Cardiac muscle contraction ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease -- -- -- IPR015089 [Cytochrome b-c1 complex subunit 10] -- -- A0A1D5RLS0 Adhesion G protein-coupled receptor G3 (Fragment) Adgrg3 54.8 65.8 48.1 44.6 47.8 53.2 1.15865384615385 0.25069467177961 0.21244961808887 Nonsignificant None -- -- G protein-coupled receptor 97 -- -- G protein-coupled receptors T Signal transduction mechanisms ; -- -- -- A0A0B4J1E6 Fc receptor, IgG, low affinity IIb Fcgr2b 185.7 164.9 138.2 170.4 178.5 180.5 0.923309406875708 0.391193112460266 -0.115113909676669 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) low affinity immunoglobulin gamma Fc receptor II-b -- ko04145 Phagosome ko04380 Osteoclast differentiation ko04662 B cell receptor signaling pathway ko04666 Fc gamma R-mediated phagocytosis ko05150 Staphylococcus aureus infection ko05152 Tuberculosis ko05162 Measles -- -- -- IPR007110 [Immunoglobulin-like domain] -- -- A7VK13 Alpha2-chimerin Chn1 371 322.7 317.6 317.9 359 356 0.97908800464711 0.755096046962478 -0.0304895535857053 Nonsignificant None 2 Biological Process:signal transduction (GO:0007165),Biological Process:intracellular signal transduction (GO:0035556) chimaerin -- -- Chimaerin and related Rho GTPase activating proteins T Signal transduction mechanisms ; IPR000198 [Rho GTPase-activating protein domain] ; IPR000980[SH2 domain] ; IPR002219[Protein kinase C-like, phorbol ester/diacylglycerol-binding domain] -- -- A0A1B0GST5 Sulfotransferase Sult2b1 19.8 18 17 21.4 18.2 21.6 0.895424836601307 0.195137917586054 -0.159355759732125 Nonsignificant None 1 Molecular Function:sulfotransferase activity (GO:0008146) alcohol sulfotransferase 2.8.2.2 ko00140 Steroid hormone biosynthesis Sulfotransferase R General function prediction only ; IPR000863 [Sulfotransferase domain] -- -- Q8VEH6 COBW domain-containing protein 1 Cbwd1 117.6 108.3 100.6 91.2 101.2 99.5 1.11853374443303 0.117881092639402 0.161608780931525 Nonsignificant None -- -- -- -- -- Cobalamin synthesis protein H Coenzyme transport and metabolism ; IPR003495 [CobW/HypB/UreG, nucleotide-binding domain] ; IPR011629[Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal] -- -- Q9D2C6 DNA-directed RNA polymerase III subunit RPC8 Polr3h 141.7 119 150 123.9 151.8 148.9 0.967263306641545 0.736014253532483 -0.0480194239263219 Nonsignificant None 1 Molecular Function:DNA-directed 5'-3' RNA polymerase activity (GO:0003899) DNA-directed RNA polymerase III subunit RPC8 -- ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways ko03020 RNA polymerase ko04623 Cytosolic DNA-sensing pathway ko05169 Epstein-Barr virus infection DNA-directed RNA polymerase subunit E' K Transcription ; IPR005576 [RNA polymerase Rpb7, N-terminal] ; IPR013238[RNA polymerase III, subunit Rpc25] -- -- Q711T7 Glutamine-dependent NAD(+) synthetase Nadsyn1 167.7 167 211 222 209.2 211.5 0.849074218142213 0.0985562428986207 -0.236037428663976 Nonsignificant None 1 Biological Process:nitrogen compound metabolic process (GO:0006807) NAD+ synthase (glutamine-hydrolysing) 6.3.5.1 ko00760 Nicotinate and nicotinamide metabolism ko01100 Metabolic pathways Predicted NAD synthase, contains CN hydrolase domain HR Coenzyme transport and metabolism ; General function prediction only ; IPR003010 [Carbon-nitrogen hydrolase] ; IPR022310[NAD/GMP synthase] -- -- E9PVB8 FYVE, RhoGEF and PH domain-containing protein 2 Fgd2 26.1 27.3 22.8 24.8 22.3 27.3 1.0241935483871 0.7762278821263 0.0344883763852906 Nonsignificant None 2 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Biological Process:regulation of Rho protein signal transduction (GO:0035023) FYVE, RhoGEF and PH domain containing 2 -- -- Predicted Rho/Rac guanine nucleotide exchange factor/faciogenital dysplasia protein 3 T Signal transduction mechanisms ; IPR000219 [Dbl homology (DH) domain] -- -- P11477 Alpha-defensin 1 Defa1 111.9 111 91.8 103.8 107.1 107.7 0.987758945386064 0.854889984347093 -0.0177690882268861 Nonsignificant None 2 Cellular Component:extracellular region (GO:0005576),Biological Process:defense response (GO:0006952) defensin, alpha -- -- -- -- -- IPR002366 [Defensin propeptide] ; IPR006081[Alpha-defensin] -- -- Q9CQT0 tRNA(His) guanylyltransferase Thg1l 422.8 415.1 360.5 419.1 465.7 409.3 0.926048991577158 0.290546963697904 -0.110839575229326 Nonsignificant None 3 Molecular Function:magnesium ion binding (GO:0000287),Biological Process:tRNA modification (GO:0006400),Molecular Function:tRNA guanylyltransferase activity (GO:0008193) tRNA(His) guanylyltransferase 2.7.7.79 -- Uncharacterized conserved protein S Function unknown ; IPR024956 [tRNAHis guanylyltransferase catalytic domain] ; IPR025845[Thg1 C-terminal domain] -- -- Q9JL11 V-type proton ATPase subunit a (Fragment) Tcirg1 16.3 18.4 17.6 17.9 16.9 17.5 1 1 0 Nonsignificant None 2 Molecular Function:hydrogen ion transmembrane transporter activity (GO:0015078),Biological Process:ATP hydrolysis coupled proton transport (GO:0015991) V-type H+-transporting ATPase subunit a -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04142 Lysosome ko04145 Phagosome ko04721 Synaptic vesicle cycle ko04966 Collecting duct acid secretion ko05152 Tuberculosis ko05165 Human papillomavirus infection ko05323 Rheumatoid arthritis Vacuolar H+-ATPase V0 sector, subunit a C Energy production and conversion ; IPR002490 [V-type ATPase, V0 complex, 116kDa subunit family] -- -- Q05D39 4933434E20Rik protein 4933434E20Rik 23.8 29.3 29.9 35.4 38.1 44.7 0.702199661590525 0.0254570189297853 -0.510046793943245 Nonsignificant None -- -- -- -- -- -- -- -- IPR010876 [NICE-3 predicted] -- -- A2AJG0 Ribonuclease P protein subunit p38 Rpp38 77.3 79.7 86.8 91.6 85.6 96.3 0.891407678244973 0.0783723847855809 -0.165842707059707 Nonsignificant None -- -- ribonucleases P/MRP protein subunit RPP38 3.1.26.5 ko03008 Ribosome biogenesis in eukaryotes ko03013 RNA transport 60S ribosomal protein 15.5kD/SNU13, NHP2/L7A family (includes ribonuclease P subunit p38), involved in splicing AJ RNA processing and modification ; Translation, ribosomal structure and biogenesis ; IPR004038 [Ribosomal protein L7Ae/L30e/S12e/Gadd45] -- -- Q8VCP4 Cytochrome P450, family 2, subfamily c, polypeptide 68 Cyp2c68 29.1 28.2 29.4 48 53 43.7 0.599170697995853 0.0173592914925864 -0.73896102330989 Significant down 3 Molecular Function:iron ion binding (GO:0005506),Molecular Function:heme binding (GO:0020037),Biological Process:oxidation-reduction process (GO:0055114) cytochrome P450 family 2 subfamily C 1.14.14.1 ko00140 Steroid hormone biosynthesis ko00590 Arachidonic acid metabolism ko00591 Linoleic acid metabolism ko00830 Retinol metabolism ko01100 Metabolic pathways ko04726 Serotonergic synapse ko04750 Inflammatory mediator regulation of TRP channels ko05204 Chemical carcinogenesis Cytochrome P450 CYP2 subfamily Q Secondary metabolites biosynthesis, transport and catabolism ; IPR001128 [Cytochrome P450] -- -- A2AKV6 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 Alkbh3 69 80.1 97.5 97.7 82.1 86.1 0.927416321925536 0.536334977223587 -0.108710977454828 Nonsignificant None -- -- mRNA N1-methyladenine demethylase 1.14.11.54 -- -- -- -- IPR027450 [Alpha-ketoglutarate-dependent dioxygenase AlkB-like] -- -- Q14A47 Translation machinery-associated protein 7 Tma7 895.6 952.3 944.9 533 503.1 471 1.8530953486829 0.0000705623391355102 0.889937115327916 Significant up -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR015157 [Translation machinery associated TMA7] -- -- Q91W78 U6 snRNA phosphodiesterase 1 Usb1 25.8 27.2 28.8 26.3 25 32.7 0.973809523809524 0.786549716912606 -0.0382884847243738 Nonsignificant None 2 Molecular Function:nuclease activity (GO:0004518),Biological Process:U6 snRNA 3'-end processing (GO:0034477) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR027521 [U6 snRNA phosphodiesterase Usb1] -- -- B2RXP1 DISP complex protein LRCH3 Lrch3 73.9 68.3 84.3 83.7 77.1 78.5 0.946510656080234 0.449839814742691 -0.0793093466049015 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Leucine-rich repeat (LRR) protein, contains calponin homology domain Z Cytoskeleton ; IPR001611 [Leucine-rich repeat] ; IPR001715[Calponin homology domain] -- -- A0A2R8W6M8 Spermatogenesis-associated serine-rich protein 2 (Fragment) Spats2 33.1 38.5 36.8 36.4 47.5 41.3 0.865814696485623 0.193349404324522 -0.207869805578747 Nonsignificant None -- -- -- -- -- -- -- -- IPR009816 [Protein of unknown function DUF1387] -- -- Q9Z222 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 B3GNT2 26.2 18.7 19.8 25.8 31.1 21.6 0.824203821656051 0.271421484980699 -0.278926941786482 Nonsignificant None 3 Biological Process:protein glycosylation (GO:0006486),Molecular Function:galactosyltransferase activity (GO:0008378),Cellular Component:membrane (GO:0016020) N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2.4.1.149 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series ko01100 Metabolic pathways Galactosyltransferases G Carbohydrate transport and metabolism ; IPR002659 [Glycosyl transferase, family 31] -- -- A4FUW1 4932417H02Rik protein (Fragment) Rptor 47.9 41.1 49.5 49.3 37.9 49.3 1.01465201465201 0.891551333197464 0.0209850251293358 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) regulatory associated protein of mTOR -- ko04136 Autophagy - other ko04140 Autophagy - animal ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko04152 AMPK signaling pathway ko04211 Longevity regulating pathway ko04213 Longevity regulating pathway - multiple species ko04910 Insulin signaling pathway ko05206 MicroRNAs in cancer Guanine nucleotide binding protein MIP1 D Cell cycle control, cell division, chromosome partitioning ; IPR000357 [HEAT repeat] ; IPR001680[WD40 repeat] ; IPR029347[Raptor, N-terminal CASPase-like domain] -- -- O70305 Ataxin-2 Atxn2 186.8 157.4 197.5 205 210.7 234.5 0.833128268225162 0.073609371008625 -0.263389465219303 Nonsignificant None -- -- -- -- -- Protein interacting with poly(A)-binding protein A RNA processing and modification ; IPR009604 [LsmAD domain] ; IPR009818[Ataxin-2, C-terminal] ; IPR025852[Ataxin 2, SM domain] -- -- A0A1B0GQW5 Interferon regulatory factor 2 Irf2 46.6 53.1 39.8 60.2 55.6 53 0.826421800947867 0.0895699872400913 -0.275049781990635 Nonsignificant None 1 Molecular Function:regulatory region DNA binding (GO:0000975) interferon regulatory factor 2 -- -- -- -- -- IPR001346 [Interferon regulatory factor DNA-binding domain] -- IRF Q7TPM9 Myotubularin-related protein 10 Mtmr10 13.2 10.3 11.5 11.8 13.6 11.1 0.958904109589041 0.679310589192603 -0.0605415419350509 Nonsignificant None -- -- myotubularin-related protein 10/11/12 -- -- Myotubularin-related phosphatidylinositol 3-phosphate 3-phosphatase MTM6 R General function prediction only ; IPR010569 [Myotubularin-like phosphatase domain] ; IPR022587[Myotubularin-related 12-like C-terminal domain] -- -- Q8R216 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial Sirt4 5.7 5.8 6 4.3 6.4 6.9 0.994318181818182 0.970520604519139 -0.00822050680496869 Nonsignificant None 1 Molecular Function:NAD+ binding (GO:0070403) NAD-dependent deacetylase sirtuin 4 3.5.1.- -- Sirtuin 4 and related class II sirtuins (SIR2 family) BK Chromatin structure and dynamics ; Transcription ; IPR003000 [Sirtuin family] -- -- Q08652 Retinol-binding protein 2 Rbp2 190.1 187.2 202.5 289.8 241.6 272.1 0.721593030491599 0.00735752640877633 -0.47074269050106 Nonsignificant None -- -- retinol binding protein 2 -- ko04977 Vitamin digestion and absorption Fatty acid-binding protein FABP I Lipid transport and metabolism ; IPR000566 [Lipocalin/cytosolic fatty-acid binding domain] -- -- Q6P3D8 Podn protein (Fragment) Podn 195.1 207.5 145.1 172.2 173.3 189.4 1.02392970648719 0.840449501156292 0.034116676682386 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- FOG: Leucine rich repeat R General function prediction only ; IPR001611 [Leucine-rich repeat] -- -- E9Q3M9 Capping protein-inhibiting regulator of actin-like Cracdl 15 16.7 12.9 23.8 19.1 22.9 0.677811550151976 0.0175326749374914 -0.561043873814937 Nonsignificant None -- -- -- -- -- -- -- -- IPR028030 [Domain of unknown function DUF4592] -- -- O88876 Short-chain dehydrogenase/reductase 3 Dhrs3 126.4 135.6 167.1 133.9 146.3 120.4 1.07114328507239 0.545877145545418 0.0991514799356779 Nonsignificant None -- -- short-chain dehydrogenase/reductase 3 1.1.1.300 ko00830 Retinol metabolism ko01100 Metabolic pathways Hydroxysteroid 17-beta dehydrogenase 11 Q Secondary metabolites biosynthesis, transport and catabolism ; IPR002347 [Short-chain dehydrogenase/reductase SDR] -- -- Q3TYA6 M-phase phosphoprotein 8 Mphosph8 33.6 31.5 31 36 42.1 36.8 0.836379460400348 0.0390542534411459 -0.257770461872363 Nonsignificant None -- -- M-phase phosphoprotein 8 -- -- FOG: Ankyrin repeat R General function prediction only ; IPR020683 [Ankyrin repeat-containing domain] ; IPR023780[Chromo domain] -- -- Q6ZPF4 Formin-like protein 3 Fmnl3 26.6 32.7 27.5 29.9 21.5 25.7 1.12581063553826 0.353237560316817 0.170964182529445 Nonsignificant None 4 Molecular Function:actin binding (GO:0003779),Biological Process:cellular component organization (GO:0016043),Molecular Function:Rho GTPase binding (GO:0017048),Biological Process:actin cytoskeleton organization (GO:0030036) -- -- -- Rac1 GTPase effector FRL TZ Signal transduction mechanisms ; Cytoskeleton ; IPR010472 [Formin, FH3 domain] ; IPR010473[Formin, GTPase-binding domain] ; IPR015425[Formin, FH2 domain] -- -- Q3UIC2 Cadherin-2 Cdh2 11.1 17 16.5 14.7 14 15 1.02059496567506 0.889124255227677 0.0294104304197064 Nonsignificant None 3 Molecular Function:calcium ion binding (GO:0005509),Biological Process:homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156),Cellular Component:membrane (GO:0016020) cadherin 2, type 1, N-cadherin -- ko04514 Cell adhesion molecules (CAMs) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) FOG: Cadherin repeats S Function unknown ; IPR000233 [Cadherin, cytoplasmic domain] ; IPR002126[Cadherin] ; IPR014868[Cadherin prodomain] -- -- Q05DP1 Serine/threonine-protein kinase 16 Stk16 50.3 49.9 54.1 66.4 49.7 48.8 0.935718617343845 0.580106310310763 -0.0958533368667323 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) serine/threonine kinase 16 2.7.11.1 -- Serine/threonine protein kinase/TGF-beta stimulated factor KIT Transcription ; Lipid transport and metabolism ; Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- Q8C660 Uncharacterized protein Fam207a 253.7 235.7 234.6 195.4 185.7 187.5 1.27330284910306 0.00165799256500037 0.34857559829304 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- A6PWR1 Protein kinase C and casein kinase II substrate protein 3 (Fragment) Pacsin3 33.7 37.4 31.6 46 46.2 44.9 0.7490882567469 0.00276322932449882 -0.416792389461031 Nonsignificant None -- -- protein kinase C and casein kinase substrate in neurons protein -- -- Adaptor protein PACSIN TUZ Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; Cytoskeleton ; IPR001060 [FCH domain] -- -- A0A1S6GWJ5 Uncharacterized protein Ints2 131.2 136.6 123.9 149.6 151.6 145.6 0.876678603401969 0.0108155339810811 -0.189880057532569 Nonsignificant None 1 Cellular Component:integrator complex (GO:0032039) integrator complex subunit 2 -- -- -- -- -- IPR029321 [Integrator complex subunit 2] -- -- Q3UK64 WHIM1 domain-containing protein (Fragment) Rsf1 120.3 130 133.5 120.3 158.8 133.1 0.93110140708394 0.47391951473876 -0.102989793343876 Nonsignificant None -- -- remodeling and spacing factor 1 -- -- -- -- -- IPR028942 [WHIM1 domain] -- -- Q3TZT4 Inositol-polyphosphate 5-phosphatase Inpp5a 193 184.9 162.7 186.2 159.7 173.6 1.04061597690087 0.584986498052696 0.0574377627431207 Nonsignificant None -- -- inositol-1,4,5-trisphosphate 5-phosphatase 3.1.3.56 ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system Inositol polyphosphate 5-phosphatase, type I I Lipid transport and metabolism ; -- -- -- Q8BMI0 F-box only protein 38 Fbxo38 64.6 71.8 124.7 87.5 111.1 84 0.923920736022647 0.747450309411753 -0.114159008021098 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) F-box protein 38 -- -- -- -- -- IPR001810 [F-box domain] -- -- Q3TGY1 Serine/Arginine-related protein 53 Rsrc1 71.9 71.5 73.6 62.1 64.4 61.4 1.15486961149548 0.000949935606685568 0.207729975911786 Nonsignificant None -- -- -- -- -- 40S ribosomal protein S12 J Translation, ribosomal structure and biogenesis ; -- -- -- Q2M4G9 Protein inhibitor of activated STAT 1 Pias1 89.3 90.6 81.3 79.6 76.9 84.7 1.08291873963516 0.145870048114946 0.114924989646346 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) E3 SUMO-protein ligase PIAS1 -- ko04120 Ubiquitin mediated proteolysis ko04630 Jak-STAT signaling pathway ko05160 Hepatitis C Zn-finger transcription factor K Transcription ; IPR004181 [Zinc finger, MIZ-type] ; IPR023321[PINIT domain] -- zf-MIZ E0CZ89 Solute carrier family 35 member B1 (Fragment) Slc35b1 42 25.7 32.4 34.6 48.8 33.9 0.853367433930094 0.445240533185621 -0.228761039192515 Nonsignificant None 1 Biological Process:transmembrane transport (GO:0055085) solute carrier family 35 (UDP-galactose transporter), member B1 -- -- UDP-galactose transporter related protein G Carbohydrate transport and metabolism ; IPR013657 [UAA transporter] -- -- Q9EQQ2 Protein YIPF5 Yipf5 222.1 227.4 267.6 218 210.5 239.3 1.0738244983528 0.382248882444057 0.102758224193361 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) protein transport protein YIP1 -- -- Rab GTPase interacting factor, Golgi membrane protein U Intracellular trafficking, secretion, and vesicular transport ; IPR006977 [Yip1 domain] -- -- Q80UY1 Carnosine N-methyltransferase Carnmt1 160.8 151.3 142.3 159.8 150.9 151.8 0.982486486486486 0.678189635011734 -0.0254905307863549 Nonsignificant None -- -- carnosine N-methyltransferase 2.1.1.22 ko00340 Histidine metabolism Putative trehalase G Carbohydrate transport and metabolism ; IPR012901 [N2227-like] -- -- Q6ZQ33 MKIAA0857 protein (Fragment) Rab11fip5 89.7 96.1 89.8 101.2 93.3 102.3 0.928571428571428 0.116446814814814 -0.106915203916512 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) Rab11 family-interacting protein 1/2/5 -- ko04144 Endocytosis -- -- -- IPR000008 [C2 domain] ; IPR019018[Rab-binding domain FIP-RBD] -- -- Q8C894 BPL/LPL catalytic domain-containing protein Lipt1 22.9 24.6 35.2 27.1 29.6 26.4 0.995186522262335 0.974809180211547 -0.00696114759906986 Nonsignificant None -- -- lipoyltransferase 1 -- ko00785 Lipoic acid metabolism ko01100 Metabolic pathways Lipoate-protein ligase A H Coenzyme transport and metabolism ; -- -- -- B2RUD2 Ubp1 protein Ubp1 105.4 126.1 112.6 139.4 144.3 119.5 0.853422619047619 0.112401645832123 -0.228667746762935 Nonsignificant None -- -- transcription factor CP2 and related proteins -- -- Transcription factor K Transcription ; IPR007604 [CP2 transcription factor] -- CP2 Q3V023 Ceramidase Naaa 108.8 115 115.9 104.4 102.1 110.7 1.07093316519546 0.0923298595928922 0.0988684471752225 Nonsignificant None -- -- N-acylethanolamine-hydrolysing acid amidase 3.5.1.- -- -- -- -- IPR029130 [Acid ceramidase, N-terminal] ; IPR029132[Choloylglycine hydrolase/NAAA C-terminal] -- -- Q8R2S9 Actin-related protein 8 Actr8 262 262.8 183.3 191.1 194.3 209.1 1.19108494533221 0.232618762930878 0.252276306434127 Nonsignificant None -- -- actin-related protein 8 -- -- Actin-related protein Z Cytoskeleton ; IPR004000 [Actin family] -- -- Q80YR4 E3 ubiquitin-protein ligase ZNF598 Znf598 184.6 206.8 178.9 204.3 227.6 210.7 0.887488328664799 0.0933447970537246 -0.172199948101704 Nonsignificant None -- -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; -- -- -- A2AR99 Calcitonin gene-related peptide type 1 receptor Calcrl 126.5 129.3 155.2 147.8 164.5 148.9 0.891153512575889 0.189855992037713 -0.166254119082727 Nonsignificant None 4 Molecular Function:G-protein coupled receptor activity (GO:0004930),Biological Process:G-protein coupled receptor signaling pathway (GO:0007186),Cellular Component:membrane (GO:0016020),Cellular Component:integral component of membrane (GO:0016021) calcitonin receptor-like -- ko04080 Neuroactive ligand-receptor interaction ko04270 Vascular smooth muscle contraction Adenylate cyclase-coupled calcitonin receptor T Signal transduction mechanisms ; IPR000832 [GPCR, family 2, secretin-like] ; IPR001879[GPCR, family 2, extracellular hormone receptor domain] -- -- V9GXP6 MARVEL domain-containing protein 1 (Fragment) Marveld1 193.4 201.9 231.9 320.4 282.8 271.3 0.717209834190966 0.0119884448930983 -0.479532824693807 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) -- -- -- Members of chemokine-like factor super family and related proteins V Defense mechanisms ; IPR008253 [Marvel domain] -- -- Q8CC47 N-acetylgalactosamine-6-sulfatase Galns 617.8 579.7 548.7 497.2 455 512 1.19259663980331 0.0232470467881209 0.254106177019835 Nonsignificant None 2 Biological Process:metabolic process (GO:0008152),Molecular Function:sulfuric ester hydrolase activity (GO:0008484) N-acetylgalactosamine-6-sulfatase 3.1.6.4 ko00531 Glycosaminoglycan degradation ko01100 Metabolic pathways ko04142 Lysosome Sulfatase R General function prediction only ; IPR000917 [Sulfatase, N-terminal] -- -- A0A3B2WD93 Protein arginine methyltransferase NDUFAF7 (Fragment) Ndufaf7 76.8 71.4 93.1 105.2 101.9 100.8 0.783696005196492 0.0289476059157744 -0.351633951829066 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR003788 [Protein arginine methyltransferase NDUFAF7] -- -- V9GX22 Transmembrane protein 254 Tmem254 51.5 59.5 57.7 73.1 67.5 74.7 0.783557826288899 0.00888531441752338 -0.351888345879668 Nonsignificant None -- -- -- -- -- -- -- -- IPR028110 [Transmembrane protein 254] -- -- Q8BK56 Uncharacterized protein Afp 45.5 53.7 74.5 68.4 60.2 61.8 0.912289915966387 0.569238979417813 -0.132435724597551 Nonsignificant None 1 Cellular Component:extracellular space (GO:0005615) alpha-fetoprotein -- ko04390 Hippo signaling pathway -- -- -- IPR014760 [Serum albumin, N-terminal] -- -- A0A0R4J086 Olfactomedin-like protein 3 Olfml3 83.6 67 61.5 58.4 61.1 67 1.1372654155496 0.296364635724151 0.185568990387955 Nonsignificant None -- -- -- -- -- Olfactomedin and related extracellular matrix glycoproteins W Extracellular structures ; IPR003112 [Olfactomedin-like domain] -- -- Q3V310 Peptidase M12B domain-containing protein Adamts17 15 12.5 18.1 18.9 17.7 16.7 0.855534709193246 0.214223650752764 -0.225101708594434 Nonsignificant None 2 Molecular Function:metalloendopeptidase activity (GO:0004222),Biological Process:proteolysis (GO:0006508) a disintegrin and metalloproteinase with thrombospondin motifs 17 3.4.24.- -- Disintegrin metalloproteinases with thrombospondin repeats O Posttranslational modification, protein turnover, chaperones ; IPR001590 [Peptidase M12B, ADAM/reprolysin] ; IPR002870[Peptidase M12B, propeptide] -- -- Q04692 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 Smarcad1 34.1 37.6 38.5 44.4 44.2 39.3 0.861610633307271 0.0510472460058433 -0.214892040310479 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 3.6.4.12 ko04550 Signaling pathways regulating pluripotency of stem cells SNF2 family DNA-dependent ATPase B Chromatin structure and dynamics ; IPR000330 [SNF2-related, N-terminal domain] ; IPR001650[Helicase, C-terminal] -- -- Q5XKN4 Protein jagunal homolog 1 Jagn1 98.7 84.3 92 92.6 108 110.2 0.884813384813385 0.159963697308426 -0.176554885108326 Nonsignificant None 2 Cellular Component:endoplasmic reticulum membrane (GO:0005789),Biological Process:endoplasmic reticulum organization (GO:0007029) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR009787 [Protein jagunal] -- -- D3Z5B2 FERM domain-containing protein 8 (Fragment) Frmd8 250.4 266.2 262.4 282.3 284.8 280.6 0.918957178247021 0.009596391936426 -0.121930458802901 Nonsignificant None -- -- -- -- -- FERM domain-containing protein KRIT1 T Signal transduction mechanisms ; IPR019748 [FERM central domain] -- -- Q6NWV4 Mcm3ap protein (Fragment) Mcm3ap 41.4 38.1 46.4 51.1 43.4 45.6 0.898643825838687 0.227822932074875 -0.154178672711802 Nonsignificant None -- -- -- -- -- Nuclear protein export factor UD Intracellular trafficking, secretion, and vesicular transport ; Cell cycle control, cell division, chromosome partitioning ; IPR005062 [SAC3/GANP/THP3] ; IPR031907[Germinal-centre associated nuclear protein, MCM3AP domain] ; IPR031908[Germinal-centre associated nuclear protein, nucleoporin homology domain] ; IPR031910[Germinal-centre associated nuclear protein, CID domain] -- -- A0A1D5RLN9 TNFAIP3-interacting protein 3 Tnip3 160.7 227.7 116.2 103.8 103.6 108.1 1.59936608557845 0.190939821481403 0.677500201106389 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q3UM17 Uncharacterized protein Rbpj 141.5 151.3 171.2 183.2 179.2 170.3 0.871034353294537 0.0741779071300227 -0.199198475546215 Nonsignificant None 3 Molecular Function:RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978),Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634) recombining binding protein suppressor of hairless -- ko04330 Notch signaling pathway ko04658 Th1 and Th2 cell differentiation ko05165 Human papillomavirus infection ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis Recombination signal binding protein-J kappa(CBF1, Su(H), HS2NF5) K Transcription ; IPR015350 [Beta-trefoil DNA-binding domain] ; IPR015351[LAG1, DNA binding] -- CSL Q8CHD5 MKIAA0696 protein (Fragment) Fbxw11 15 13.1 9.1 11.6 15.1 11.9 0.963730569948187 0.832548302852183 -0.0532982261600491 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:protein dimerization activity (GO:0046983) F-box and WD-40 domain protein 1/11 -- ko04114 Oocyte meiosis ko04120 Ubiquitin mediated proteolysis ko04218 Cellular senescence ko04310 Wnt signaling pathway ko04340 Hedgehog signaling pathway ko04390 Hippo signaling pathway ko04710 Circadian rhythm Beta-TrCP (transducin repeats containing)/Slimb proteins S Function unknown ; IPR001680 [WD40 repeat] ; IPR001810[F-box domain] ; IPR021977[D domain of beta-TrCP] -- -- A0A1D5RLV7 WD repeat and FYVE domain-containing protein 3 Wdfy3 21.7 24.9 17.6 26.3 24.8 23.1 0.865229110512129 0.221843868499661 -0.2088458894985 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:metal ion binding (GO:0046872) WD repeat and FYVE domain-containing protein 3 -- -- Lysosomal trafficking regulator LYST and related BEACH and WD40 repeat proteins TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR000306 [FYVE zinc finger] ; IPR000409[BEACH domain] ; IPR001680[WD40 repeat] ; IPR023362[PH-BEACH domain] ; IPR031570[Domain of unknown function DUF4704] -- -- P97304 DNA-directed RNA polymerases I and III subunit RPAC2 Polr1d 271.3 282.1 289.6 198.6 209 219.4 1.3444976076555 0.000850515797982878 0.427067188140043 Nonsignificant None 1 Molecular Function:protein dimerization activity (GO:0046983) DNA-directed RNA polymerases I and III subunit RPAC2 -- ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways ko03020 RNA polymerase ko04623 Cytosolic DNA-sensing pathway ko05169 Epstein-Barr virus infection DNA-directed RNA polymerase, subunit L K Transcription ; IPR009025 [DNA-directed RNA polymerase, RBP11-like dimerisation domain] -- -- A0A3B2W458 Protein yippee-like 5 (Fragment) Ypel5 76 76.1 72 71.6 74.7 77 1.00358262427228 0.903560017776106 0.00515939768791975 Nonsignificant None -- -- -- -- -- Predicted Yippee-type zinc-binding protein R General function prediction only ; -- -- -- Q6NWW9 Fibronectin type III domain-containing protein 3B Fndc3b 122.8 135.8 131.1 143.7 140.6 127.6 0.946103423160962 0.30037227320783 -0.0799301946992194 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR003961 [Fibronectin type III] -- -- Q99LX5 Multiple myeloma tumor-associated protein 2 homolog Mmtag2 31.3 34.3 32.7 33.6 44.2 27.8 0.930871212121212 0.644143564341463 -0.103346513017873 Nonsignificant None -- -- -- -- -- Predicted coiled-coil protein R General function prediction only ; IPR019315 [Kinase phosphorylation domain] -- -- Q99P69 Kinetochore protein Nuf2 Nuf2 18.9 23.9 28.3 26.9 22.1 26.3 0.944223107569721 0.675623940364521 -0.082800305052513 Nonsignificant None 1 Biological Process:mitotic nuclear division (GO:0007067) kinetochore protein Nuf2 -- -- Centromere-associated protein NUF2 D Cell cycle control, cell division, chromosome partitioning ; IPR005549 [Kinetochore protein Nuf2] -- -- H3BKM2 Nuclear-interacting partner of ALK Zc3hc1 29 22.8 27.8 32.6 32.2 34.1 0.804853387259858 0.0316283082203141 -0.313202090215462 Nonsignificant None 2 Cellular Component:nucleus (GO:0005634),Molecular Function:zinc ion binding (GO:0008270) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR012935 [Zinc finger, C3HC-like] -- -- D3Z5S8 Terminal nucleotidyltransferase 5A Tent5a 50.7 56.1 60.4 66.6 76.2 71 0.782039289055192 0.0170124609453742 -0.354687005639608 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR012937 [FAM46 family] -- -- Q8CJ61 CKLF-like MARVEL transmembrane domain-containing protein 4 Cmtm4 224.8 232.5 185.2 234.1 267 220.8 0.890012467100706 0.257917612226177 -0.168102549709013 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) -- -- -- Members of chemokine-like factor super family and related proteins V Defense mechanisms ; IPR008253 [Marvel domain] -- -- E9Q2M9 WD repeat- and FYVE domain-containing protein 4 Wdfy4 32.1 34.4 33 39.9 46.4 37.4 0.804365400161681 0.0433302926885331 -0.314077069545359 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Lysosomal trafficking regulator LYST and related BEACH and WD40 repeat proteins TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR000409 [BEACH domain] ; IPR001680[WD40 repeat] ; IPR023362[PH-BEACH domain] -- -- Q3U3M5 Cyclin-K Ccnk 54.8 53.3 49.2 66.8 63.5 50 0.872434830837493 0.229033130412003 -0.196880726016655 Nonsignificant None 1 Cellular Component:nucleus (GO:0005634) -- -- -- CDK9 kinase-activating protein cyclin T D Cell cycle control, cell division, chromosome partitioning ; IPR004367 [Cyclin, C-terminal domain] ; IPR006671[Cyclin, N-terminal] -- -- D3Z5Y5 Choline/ethanolaminephosphotransferase 1 (Fragment) Cept1 474.7 462.2 428.1 451.4 467.2 420.2 1.01956976396773 0.679122261998571 0.0279604950080476 Nonsignificant None -- -- -- -- ko00440 Phosphonate and phosphinate metabolism ko00564 Glycerophospholipid metabolism ko00565 Ether lipid metabolism ko01100 Metabolic pathways sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases I Lipid transport and metabolism ; -- -- -- Q8BGY6 Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase B3gnt5 27.3 21.8 14.3 26 22.3 19.8 0.930983847283407 0.726577939760142 -0.103171957872664 Nonsignificant None 3 Biological Process:protein glycosylation (GO:0006486),Molecular Function:galactosyltransferase activity (GO:0008378),Cellular Component:membrane (GO:0016020) beta-1,3-N-acetylglucosaminyltransferase 5 2.4.1.206 ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series ko01100 Metabolic pathways Galactosyltransferases G Carbohydrate transport and metabolism ; IPR002659 [Glycosyl transferase, family 31] -- -- A0A1C7CYU4 Syntaxin-3 Stx3 40.3 33.8 58.5 48.8 44.2 42.1 0.981495188749075 0.918526430644337 -0.0269468992130969 Nonsignificant None -- -- syntaxin 1B/2/3 -- ko04130 SNARE interactions in vesicular transport ko04721 Synaptic vesicle cycle SNARE protein Syntaxin 1 and related proteins U Intracellular trafficking, secretion, and vesicular transport ; -- -- -- Q8K2T4 Ubiquinol-cytochrome-c reductase complex assembly factor 3 Uqcc3 191.1 169.5 184.4 176.7 172.2 179.7 1.03102534998108 0.463142329394332 0.0440798049100814 Nonsignificant None -- -- -- -- -- -- -- -- IPR027896 [Protein of unknown function DUF4574] -- -- Q64697 Protein tyrosine phosphatase receptor type C-associated protein Ptprcap 79.2 91.7 71.2 91.4 88.7 82.4 0.922285714285714 0.356777729311699 -0.116714343441911 Nonsignificant None -- -- -- -- -- -- -- -- IPR016553 [Protein tyrosine phosphatase receptor type C-associated protein] -- -- B7ZP45 Lrig1 protein Lrig1 89.3 75.4 88.2 82 69.9 73.7 1.12101063829787 0.186562631820016 0.164799969264445 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Membrane glycoprotein LIG-1 T Signal transduction mechanisms ; IPR000372 [Leucine-rich repeat N-terminal domain] ; IPR000483[Cysteine-rich flanking region, C-terminal] ; IPR001611[Leucine-rich repeat] ; IPR013098[Immunoglobulin I-set] -- -- A0A1S6GWJ3 Thymidine kinase Tk1 92 95.7 117.6 122.7 131.2 117.9 0.821140398063475 0.0671270695158591 -0.284299180712702 Nonsignificant None 2 Molecular Function:thymidine kinase activity (GO:0004797),Molecular Function:ATP binding (GO:0005524) thymidine kinase 2.7.1.21 ko00240 Pyrimidine metabolism ko00983 Drug metabolism - other enzymes ko01100 Metabolic pathways Thymidine kinase F Nucleotide transport and metabolism ; IPR001267 [Thymidine kinase] -- -- Q99JP6 Homer protein homolog 3 Homer3 166.9 148.7 155.8 159 171.7 165.2 0.950594877999597 0.273628294637742 -0.0730974667633024 Nonsignificant None -- -- homer -- ko04068 FoxO signaling pathway ko04724 Glutamatergic synapse -- -- -- IPR000697 [WH1/EVH1 domain] -- -- Q6P3E7 Polyamine deacetylase HDAC10 Hdac10 34.6 27 38.7 32.8 37.9 29.6 1 0.999999999999999 0.000000000000000320342650381492 Nonsignificant None -- -- histone deacetylase 10 3.5.1.98 ko05034 Alcoholism ko05165 Human papillomavirus infection ko05203 Viral carcinogenesis Histone deacetylase complex, catalytic component HDA1 B Chromatin structure and dynamics ; IPR023801 [Histone deacetylase domain] -- -- E9QAD3 Metal-response element-binding transcription factor 2 Mtf2 214.2 231.7 247 231.2 236.8 213.7 1.01642951444917 0.766687063107196 0.0235101731950085 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) polycomb-like protein 2 -- -- Polycomb-like PHD Zn-finger protein R General function prediction only ; IPR019787 [Zinc finger, PHD-finger] ; IPR025894[Polycomb-like MTF2 factor 2, C-terminal domain] -- -- Q3UZN6 Phosducin domain-containing protein Pdcl 38.7 36.3 40.7 54.7 59.8 44.5 0.727672955974843 0.0366490732474156 -0.458637901064228 Nonsignificant None -- -- -- -- -- Conserved phosducin-like protein T Signal transduction mechanisms ; IPR024253 [Phosducin, thioredoxin-like domain] -- -- A0A4W9 Neuronal growth regulator 1 Negr1 134.6 129.4 168.1 163.6 153.1 153.6 0.918775249840527 0.369366824717653 -0.122216101268248 Nonsignificant None -- -- neuronal growth regulator 1 -- ko04514 Cell adhesion molecules (CAMs) FOG: Immunoglobulin C-2 Type/fibronectin type III domains T Signal transduction mechanisms ; IPR013098 [Immunoglobulin I-set] -- -- Q8CAA7 Glucose 1,6-bisphosphate synthase Pgm2l1 56.5 65.4 47.5 69 62.2 74 0.825536062378168 0.126414171255116 -0.276596856274856 Nonsignificant None 2 Biological Process:carbohydrate metabolic process (GO:0005975),Biological Process:organic substance metabolic process (GO:0071704) glucose-1,6-bisphosphate synthase 2.7.1.106 ko00500 Starch and sucrose metabolism Phosphoglucomutase/phosphomannomutase G Carbohydrate transport and metabolism ; IPR005843 [Alpha-D-phosphohexomutase, C-terminal] ; IPR005844[Alpha-D-phosphohexomutase, alpha/beta/alpha domain I] ; IPR005845[Alpha-D-phosphohexomutase, alpha/beta/alpha domain II] ; IPR005846[Alpha-D-phosphohexomutase, alpha/beta/alpha domain III] -- -- Q8C3Y4 Kinetochore-associated protein 1 Kntc1 83.9 80.9 76.1 58.2 67.5 65.9 1.25730688935282 0.0109136923717897 0.33033683250229 Nonsignificant None -- -- kinetochore-associated protein 1 -- -- Kinetochore component D Cell cycle control, cell division, chromosome partitioning ; IPR019527 [RZZ complex, subunit KNTC1/ROD, C-terminal] -- -- A0A0A6YW92 DALR anticodon-binding domain-containing protein 3 Dalrd3 43.2 53.3 60.7 37.4 47.3 42.9 1.23197492163009 0.165514333057551 0.300972888493737 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- P62876 DNA-directed RNA polymerases I, II, and III subunit RPABC5 Polr2l 246.7 231.8 239.3 208.8 225 205.9 1.12208847897452 0.0238252331783867 0.166186439890529 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Molecular Function:DNA-directed 5'-3' RNA polymerase activity (GO:0003899) DNA-directed RNA polymerases I, II, and III subunit RPABC5 -- ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways ko03020 RNA polymerase ko04623 Cytosolic DNA-sensing pathway ko05016 Huntington's disease ko05169 Epstein-Barr virus infection DNA-directed RNA polymerase, subunit RPB10 K Transcription ; IPR000268 [DNA-directed RNA polymerase, subunit N/Rpb10] -- -- Q8R0L9 Transcriptional adapter 3 Tada3 31.9 40.2 32.7 43.1 41.2 31.1 0.908145580589255 0.482290712819878 -0.139004507108032 Nonsignificant None -- -- transcriptional adapter 3 -- ko05165 Human papillomavirus infection Histone acetyltransferases PCAF/SAGA/ADA, subunit TADA3L/NGG1 B Chromatin structure and dynamics ; IPR019340 [Histone acetyltransferases subunit 3] -- -- Q6DFV5 Probable helicase with zinc finger domain Helz 122.6 124.4 105.2 100.1 94.8 95 1.21490169023801 0.0309737141139648 0.280839575769812 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) -- -- -- RNA helicase A RNA processing and modification ; IPR000571 [Zinc finger, CCCH-type] -- -- Q99MP8 BRCA1-associated protein Brap 236.7 235.2 266.2 309.8 290 340.9 0.784628468162007 0.0196463835705997 -0.349918414161281 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:zinc ion binding (GO:0008270) BRCA1-associated protein 2.3.2.27 ko04014 Ras signaling pathway Cytoplasmic Zn-finger protein BRAP2 (BRCA1 associated protein) R General function prediction only ; IPR001607 [Zinc finger, UBP-type] ; IPR001841[Zinc finger, RING-type] ; IPR011422[BRCA1-associated 2] -- -- Q80XL7 Metallophosphoesterase 1 Mppe1 142.1 132.5 102.2 104.6 132.5 136.6 1.00829542413701 0.950596116525622 0.0119184012320387 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) -- -- -- Cell division control protein/predicted DNA repair exonuclease L Replication, recombination and repair ; IPR004843 [Calcineurin-like phosphoesterase domain, ApaH type] -- -- D3Z4R2 Non-specific serine/threonine protein kinase Kalrn 95.2 95 59.9 64.1 67.7 69.6 1.24180734856008 0.299886920872011 0.312441374174186 Nonsignificant None 6 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468),Biological Process:regulation of Rho protein signal transduction (GO:0035023) triple functional domain protein 2.7.11.1 -- Guanine nucleotide exchange factor for Rho and Rac GTPases T Signal transduction mechanisms ; IPR000219 [Dbl homology (DH) domain] ; IPR000719[Protein kinase domain] ; IPR003961[Fibronectin type III] ; IPR013098[Immunoglobulin I-set] -- -- P33680 Guanylin Guca2a 49.9 36.4 32.4 42.7 36.8 37.8 1.01193520886616 0.937581436675924 0.0171169216133981 Nonsignificant None 2 Cellular Component:extracellular region (GO:0005576),Molecular Function:guanylate cyclase activator activity (GO:0030250) -- -- -- -- -- -- IPR000879 [Guanylin] -- -- B2RRI2 Protein strawberry notch homolog 1 Sbno1 199.9 207.8 190.4 157.3 157.9 160.5 1.2573050241749 0.00134873727959421 0.330334692304896 Nonsignificant None -- -- -- -- -- Nuclear helicase MOP-3/SNO (DEAD-box superfamily) KT Transcription ; Signal transduction mechanisms ; IPR026937 [Strawberry notch, helicase C domain] -- -- P63166 Small ubiquitin-related modifier 1 Sumo1 851.8 868.8 867.9 715.4 763.1 767.4 1.1525446368939 0.0028809403284405 0.204822625863658 Nonsignificant None -- -- small ubiquitin-related modifier -- ko03013 RNA transport ko05418 Fluid shear stress and atherosclerosis Ubiquitin-like proteins O Posttranslational modification, protein turnover, chaperones ; IPR022617 [Rad60/SUMO-like domain] -- -- Q8BV57 Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D Ssc5d 51 64.6 54.1 65.9 68.8 51.4 0.911875335840946 0.464980317371395 -0.133091490516488 Nonsignificant None 2 Molecular Function:scavenger receptor activity (GO:0005044),Cellular Component:membrane (GO:0016020) -- -- -- -- -- -- IPR001190 [SRCR domain] -- -- J7I1C3 Rif1 Rif1 37.5 43.3 36.8 30.3 37 31.2 1.19390862944162 0.0963918976728531 0.255692430492625 Nonsignificant None -- -- telomere-associated protein RIF1 -- ko04550 Signaling pathways regulating pluripotency of stem cells -- -- -- IPR022031 [Telomere-associated protein Rif1, N-terminal] -- -- Q8BTG3 T-complex protein 11-like protein 1 Tcp11l1 42.1 38.2 38.5 44.2 50.4 39.1 0.888556469708302 0.228800626876983 -0.170464629292587 Nonsignificant None -- -- -- -- -- SOK1 kinase belonging to the STE20/SPS1/GC kinase family T Signal transduction mechanisms ; IPR008862 [T-complex 11] -- -- J3QNK5 Histone deacetylase complex subunit SAP130 Sap130 190.2 156.3 196.4 162 146.1 159.2 1.1617804408303 0.133002988600733 0.216337446664485 Nonsignificant None -- -- histone deacetylase complex subunit SAP130 -- -- -- -- -- IPR031963 [Histone deacetylase complex subunit SAP130, C-terminal domain] -- -- A0A2I3BPG4 Biotin--protein ligase Hlcs 8.4 8.3 7.1 8.8 7.2 7.6 1.00847457627119 0.921665152224347 0.0121747139461022 Nonsignificant None 1 Biological Process:cellular protein modification process (GO:0006464) -- -- ko00780 Biotin metabolism ko01100 Metabolic pathways Biotin holocarboxylase synthetase/biotin-protein ligase H Coenzyme transport and metabolism ; IPR003142 [Biotin protein ligase, C-terminal] ; IPR004143[Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain] -- -- Q8BHV7 Protein-ribulosamine 3-kinase (Fragment) Fn3krp 97.8 94.3 97.5 103.6 101.2 100.6 0.948264571054355 0.0219809330681352 -0.0766384597136462 Nonsignificant None -- -- protein-ribulosamine 3-kinase 2.7.1.172 -- Predicted kinase R General function prediction only ; IPR016477 [Fructosamine/Ketosamine-3-kinase] -- -- Q8C156 Condensin complex subunit 2 Ncaph 108.1 114.4 142.9 115 134.9 123.4 0.978837396196089 0.839156293385963 -0.0308588746755813 Nonsignificant None 2 Cellular Component:condensin complex (GO:0000796),Biological Process:mitotic chromosome condensation (GO:0007076) condensin complex subunit 2 -- Chromosome condensation complex Condensin, subunit H BD Chromatin structure and dynamics ; Cell cycle control, cell division, chromosome partitioning ; IPR022816 [Condensin complex subunit 2/barren] -- -- Q91VA3 Calpain-8 Capn8 178.3 196.7 168.1 172.2 154.2 171 1.09187776437475 0.209169795682052 0.126811355707294 Nonsignificant None 3 Molecular Function:calcium-dependent cysteine-type endopeptidase activity (GO:0004198),Cellular Component:intracellular (GO:0005622),Biological Process:proteolysis (GO:0006508) calpain-8 3.4.22.- -- Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) OT Posttranslational modification, protein turnover, chaperones ; Signal transduction mechanisms ; IPR001300 [Peptidase C2, calpain, catalytic domain] ; IPR022682[Peptidase C2, calpain, large subunit, domain III] -- -- Q9QY73 Transmembrane protein 59 Tmem59 22.1 28.9 23.9 26.9 42.1 19.4 0.847285067873303 0.554254092730068 -0.239080650932681 Nonsignificant None -- -- -- -- -- -- -- -- IPR022065 [Uncharacterised protein family, TMEM59] -- -- G3UYA1 DENN domain-containing protein 3 Dennd3 121.6 129.8 144.8 158.8 161.2 143.5 0.854800431499461 0.0627234837555052 -0.226340458623407 Nonsignificant None -- -- DENN domain-containing protein 3 -- -- Calmodulin-binding protein CRAG, contains DENN domain T Signal transduction mechanisms ; IPR001194 [DENN domain] -- -- Q6PDS4 Frataxin, mitochondrial Fxn 247.2 242.3 249.2 296.7 286.7 296.1 0.839909039226833 0.000255238412862104 -0.251695000046001 Nonsignificant None 2 Molecular Function:ferric iron binding (GO:0008199),Biological Process:iron-sulfur cluster assembly (GO:0016226) frataxin 1.16.3.1 ko00860 Porphyrin and chlorophyll metabolism Mitochondrial matrix protein frataxin, involved in Fe/S protein biosynthesis P Inorganic ion transport and metabolism ; IPR002908 [Frataxin/CyaY] -- -- Q9Z2G1 Protein fem-1 homolog A-A Fem1aa 133 115.4 94.8 134.7 113.9 131.1 0.903871477482223 0.394629563307349 -0.145810446119543 Nonsignificant None -- -- -- -- -- Ankyrin repeat protein R General function prediction only ; IPR020683 [Ankyrin repeat-containing domain] -- -- A0A338P6N4 Beta/gamma crystallin domain-containing protein 3 Crybg3 129.9 136.2 132.7 126.2 124.6 131.7 1.04261437908497 0.126151824602746 0.0602056619308195 Nonsignificant None -- -- -- -- -- -- -- -- IPR000772 [Ricin B, lectin domain] ; IPR001064[Beta/gamma crystallin] -- -- H9H9S3 Zinc finger E-box-binding homeobox 2 Zeb2 63.1 53 47 45 40.1 41.3 1.29034810126582 0.0678748621445676 0.367760318534782 Nonsignificant None -- -- zinc finger homeobox protein 1/2 -- ko05206 MicroRNAs in cancer Homeobox transcription factor SIP1 K Transcription ; IPR008598 [Drought induced 19 protein type, zinc-binding domain] -- zf-C2H2 B1AXP6 Mitochondrial import receptor subunit TOM5 homolog Tomm5 352.1 355.5 440.4 381.8 412.7 368.9 0.98676293622142 0.879102361865785 -0.0192245672648985 Nonsignificant None 1 Cellular Component:mitochondrial outer membrane translocase complex (GO:0005742) mitochondrial import receptor subunit TOM5 -- -- -- -- -- IPR029179 [Mitochondrial import receptor subunit TOM5 homologue] -- -- Q99M04 Lipoyl synthase, mitochondrial Lias 74 65.9 88.7 96.1 88.9 96.9 0.810925860234126 0.0676432614092541 -0.302358074355944 Nonsignificant None 2 Molecular Function:catalytic activity (GO:0003824),Molecular Function:iron-sulfur cluster binding (GO:0051536) lipoyl synthase 2.8.1.8 ko00785 Lipoic acid metabolism ko01100 Metabolic pathways Lipoate synthase H Coenzyme transport and metabolism ; IPR007197 [Radical SAM] ; IPR031691[Lipoyl synthase, N-terminal] -- -- A2AGH8 Mediator of RNA polymerase II transcription subunit 12 Med12 62.5 52.3 56.3 58.2 53.4 53.6 1.03571428571429 0.589329341529394 0.0506260730699678 Nonsignificant None 4 Molecular Function:RNA polymerase II transcription cofactor activity (GO:0001104),Biological Process:regulation of transcription from RNA polymerase II promoter (GO:0006357),Molecular Function:beta-catenin binding (GO:0008013),Cellular Component:mediator complex (GO:0016592) mediator of RNA polymerase II transcription subunit 12 -- ko04919 Thyroid hormone signaling pathway Thyroid hormone receptor-associated protein complex, subunit TRAP230 K Transcription ; IPR019035 [Mediator complex, subunit Med12] ; IPR021989[Mediator complex, subunit Med12, catenin-binding] ; IPR021990[Mediator complex, subunit Med12, LCEWAV-domain] -- -- Q6Y5D8 Rho GTPase-activating protein 10 Arhgap10 211.3 218.6 189.6 192.3 203.9 218.8 1.00731707317073 0.903391630114375 0.0105178719139993 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Biological Process:signal transduction (GO:0007165) Rho GTPase-activating protein 10 -- ko05100 Bacterial invasion of epithelial cells Oligophrenin-1 and related Rho GTPase-activating proteins T Signal transduction mechanisms ; IPR000198 [Rho GTPase-activating protein domain] ; IPR001452[SH3 domain] ; IPR001849[Pleckstrin homology domain] -- -- Q3TC56 Uncharacterized protein Oxa1l 95.7 102 93.7 128.2 106 92.6 0.891676866585068 0.331121234003356 -0.165407106081171 Nonsignificant None 2 Cellular Component:integral component of membrane (GO:0016021),Biological Process:protein insertion into membrane (GO:0051205) YidC/Oxa1 family membrane protein insertase -- ko03060 Protein export Inner membrane protein translocase involved in respiratory chain assembly OU Posttranslational modification, protein turnover, chaperones ; Intracellular trafficking, secretion, and vesicular transport ; IPR001708 [Membrane insertase OXA1/ALB3/YidC] -- -- Q3UFC9 PH domain-containing protein Plekhb2 119.7 146.4 178 249.3 219 196.6 0.667919987968115 0.0317741056350263 -0.5822528063727 Nonsignificant None -- -- -- -- -- -- -- -- IPR001849 [Pleckstrin homology domain] -- -- Q6PAQ8 Tead1 protein Tead1 373.6 386.5 427 402.8 394.9 410.4 0.982617333002235 0.696590142412249 -0.0252984069730533 Nonsignificant None -- -- transcriptional enhancer factor -- ko04390 Hippo signaling pathway ko04392 Hippo signaling pathway - multiple species TEF-1 and related transcription factor, TEAD family K Transcription ; IPR000818 [TEA/ATTS domain] -- TEA Q7TQE6 Macoilin Maco1 107.7 103.1 68.1 91.4 86.3 79.1 1.08605919003115 0.601309042257666 0.119102731906009 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019130 [Macoilin] -- -- Q91YE3 Egl nine homolog 1 Egln1 59.9 58.5 55.5 64.9 77.3 65 0.839285714285714 0.0618789802215235 -0.252766070379967 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) hypoxia-inducible factor prolyl hydroxylase 1.14.11.29 ko04066 HIF-1 signaling pathway ko05200 Pathways in cancer ko05211 Renal cell carcinoma EGL-Nine (EGLN) protein T Signal transduction mechanisms ; IPR002893 [Zinc finger, MYND-type] ; IPR005123[Oxoglutarate/iron-dependent dioxygenase] -- -- Q5NCQ5 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 Dph1 25.1 26.2 14.3 18.7 29.4 19.5 0.970414201183432 0.902762919417284 -0.0433274316641005 Nonsignificant None -- -- 2-(3-amino-3-carboxypropyl)histidine synthase 2.5.1.108 -- Diphthamide biosynthesis protein J Translation, ribosomal structure and biogenesis ; IPR016435 [Diphthamide synthesis DPH1/DPH2] -- -- A2A7P9 Small vasohibin-binding protein Svbp 165.3 155.2 230 186.6 197.1 174.5 0.986205661053386 0.92104580991714 -0.020039560614336 Nonsignificant None -- -- -- -- -- -- -- -- IPR031378 [Small vasohibin-binding protein] -- -- Q9R0M3 Sushi-repeat-containing protein SRPX Srpx 58.1 46.6 51.7 56.4 57.8 66.5 0.865522966242391 0.152234657829346 -0.208355993557247 Nonsignificant None -- -- -- -- -- -- -- -- IPR000436 [Sushi/SCR/CCP domain] ; IPR003410[HYR domain] ; IPR025232[Domain of unknown function DUF4174] -- -- Q924A2 Protein capicua homolog Cic 30.2 33.6 30.8 31.1 41.4 28.5 0.936633663366337 0.628344310979573 -0.0944432042997616 Nonsignificant None -- -- capicua transcriptional repressor -- HMG-box transcription factor Capicua and related proteins K Transcription ; IPR009071 [High mobility group box domain] ; IPR032147[Domain of unknown function DUF4819] -- HMG Q8BHA3 D-aminoacyl-tRNA deacylase 2 Dtd2 209.5 181.7 171.2 213.3 214.2 224.6 0.862444410366508 0.0671784771794805 -0.213496625324444 Nonsignificant None 2 Cellular Component:cytoplasm (GO:0005737),Biological Process:D-amino acid catabolic process (GO:0019478) -- -- -- D-Tyr-tRNA (Tyr) deacylase J Translation, ribosomal structure and biogenesis ; IPR003732 [D-aminoacyl-tRNA deacylase DTD] -- -- Q5SYL3 Protein KIAA0100 Kiaa0100 75.9 68.8 56 71.6 68.1 73.2 0.942696101456083 0.536010714159265 -0.0851353330896767 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019439 [FMP27, N-terminal] ; IPR019441[FMP27, GFWDK domain] ; IPR019443[FMP27, C-terminal] -- -- D3YY98 Syntaxin-18 (Fragment) Stx18 24.9 20.4 35.2 37.2 29.6 29.7 0.83419689119171 0.350649346344656 -0.261540159153464 Nonsignificant None -- -- syntaxin 18 -- ko04130 SNARE interactions in vesicular transport ko04145 Phagosome SNARE protein Syntaxin 18/UFE1 U Intracellular trafficking, secretion, and vesicular transport ; -- -- -- Q3UKK7 General transcription and DNA repair factor IIH helicase subunit XPD Ercc2 147.6 138.6 132.4 147.4 155.7 156.5 0.910791993037424 0.0609541408494823 -0.134806486390404 Nonsignificant None 6 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:DNA binding (GO:0003677),Molecular Function:ATP-dependent DNA helicase activity (GO:0004003),Molecular Function:ATP binding (GO:0005524),Biological Process:nucleobase-containing compound metabolic process (GO:0006139),Molecular Function:ATP-dependent helicase activity (GO:0008026) DNA excision repair protein ERCC-2 3.6.4.12 ko03022 Basal transcription factors ko03420 Nucleotide excision repair RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, 5'-3' helicase subunit RAD3 KL Transcription ; Replication, recombination and repair ; IPR006555 [ATP-dependent helicase, C-terminal] ; IPR010614[DEAD2] ; IPR010643[Helical and beta-bridge domain] -- -- Q9D7V2 LysM and putative peptidoglycan-binding domain-containing protein 2 Lysmd2 95.2 97.4 89.8 104.2 94.2 98 0.9527665317139 0.274275911835944 -0.0698053590346534 Nonsignificant None -- -- -- -- -- -- -- -- IPR018392 [LysM domain] -- -- A0A140LHU0 Disintegrin and metalloproteinase domain-containing protein 9 Adam9 43.6 47.4 57.7 59.6 53.7 52.6 0.896323086196504 0.293014194923086 -0.157909238903445 Nonsignificant None 2 Molecular Function:metalloendopeptidase activity (GO:0004222),Biological Process:proteolysis (GO:0006508) disintegrin and metalloproteinase domain-containing protein 9 3.4.24.- -- Meltrins, fertilins and related Zn-dependent metalloproteinases of the ADAMs family O Posttranslational modification, protein turnover, chaperones ; IPR001590 [Peptidase M12B, ADAM/reprolysin] ; IPR001762[Disintegrin domain] ; IPR002870[Peptidase M12B, propeptide] ; IPR006586[ADAM, cysteine-rich] -- -- G3X8S5 DnaJ homolog subfamily B member 6 Dnajb6 165 169.1 204.4 251.2 283.2 221.9 0.712019040063467 0.0285770478162451 -0.490012274148126 Nonsignificant None -- -- DnaJ homolog subfamily B member 6 -- -- Molecular chaperone (DnaJ superfamily) O Posttranslational modification, protein turnover, chaperones ; IPR001623 [DnaJ domain] -- -- E0CZ56 tRNA methyltransferase 10 homolog A (Fragment) Trmt10a 17.5 19.5 17.3 14.4 21.9 12.1 1.12190082644628 0.553054907736873 0.165945150529767 Nonsignificant None -- -- tRNA (guanine9-N1)-methyltransferase 2.1.1.221 -- Uncharacterized conserved protein S Function unknown ; -- -- -- Q3U046 WW domain-containing protein (Fragment) Yap1 262.3 260.5 297.3 296.9 303.8 293.2 0.917440429578253 0.117716830737549 -0.124313609674979 Nonsignificant None -- -- transcriptional coactivator YAP1 -- ko04390 Hippo signaling pathway ko04392 Hippo signaling pathway - multiple species Ubiquitin protein ligase RSP5/NEDD4 O Posttranslational modification, protein turnover, chaperones ; -- -- -- Q3UV74 Integrin beta-2-like protein Itgb2l 124.1 155.7 123.6 78.4 83.7 77.2 1.68575010447137 0.0071653036288446 0.753390687074463 Significant up -- -- integrin beta 2 -- ko04015 Rap1 signaling pathway ko04145 Phagosome ko04390 Hippo signaling pathway ko04514 Cell adhesion molecules (CAMs) ko04610 Complement and coagulation cascades ko04650 Natural killer cell mediated cytotoxicity ko04670 Leukocyte transendothelial migration ko04810 Regulation of actin cytoskeleton ko05133 Pertussis ko05134 Legionellosis ko05140 Leishmaniasis ko05144 Malaria ko05146 Amoebiasis ko05150 Staphylococcus aureus infection ko05152 Tuberculosis ko05166 HTLV-I infection ko05323 Rheumatoid arthritis ko05416 Viral myocarditis Integrin beta subunit (N-terminal portion of extracellular region) TW Signal transduction mechanisms ; Extracellular structures ; IPR002369 [Integrin beta subunit, VWA domain] ; IPR033760[Integrin beta N-terminal] -- -- Q921V7 Choline transporter-like protein 3 Slc44a3 113.5 114.6 113.2 113.2 112.6 123.3 0.977656831853337 0.532686534830271 -0.032599942453888 Nonsignificant None -- -- solute carrier family 44 (choline transporter-like protein), member 3 -- ko05231 Choline metabolism in cancer Choline transporter-like protein I Lipid transport and metabolism ; IPR007603 [Choline transporter-like] -- -- A0A3Q4EGK3 Latent-transforming growth factor beta-binding protein 1 Ltbp1 234.9 215.7 246.7 279.8 286.5 279.6 0.824329116916893 0.00601239412164572 -0.278707640312326 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) latent transforming growth factor beta binding protein 1 -- ko04350 TGF-beta signaling pathway Fibrillins and related proteins containing Ca2+-binding EGF-like domains T Signal transduction mechanisms ; IPR001881 [EGF-like calcium-binding domain] ; IPR017878[TB domain] -- -- F6VMC4 Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (Fragment) Jmjd6 67.5 63.6 55.8 57.4 66.8 59.7 1.0163132137031 0.833337625815342 0.0233450893332203 Nonsignificant None -- -- histone arginine demethylase JMJD6 1.14.11.- -- Phosphatidylserine-specific receptor PtdSerR, contains JmjC domain BT Chromatin structure and dynamics ; Signal transduction mechanisms ; IPR003347 [JmjC domain] -- -- Q3UFM1 SERPIN domain-containing protein Serpinb8 66.7 58.7 51.4 49.7 60.2 60.4 1.0381679389313 0.721228548646119 0.0540398397128894 Nonsignificant None -- -- serpin B8 -- -- Serpin V Defense mechanisms ; IPR023796 [Serpin domain] -- -- Q99KE5 Ercc6l protein Ercc6l 42.1 37.6 31.9 36.4 38.6 35.3 1.01178603807797 0.895806719469022 0.0169042362378052 Nonsignificant None -- -- DNA excision repair protein ERCC-6-like 3.6.4.12 -- -- -- -- -- -- -- Q8VEL2 Myotubularin-related protein 14 Mtmr14 21.8 29.3 26.1 30.1 29.4 21.5 0.953086419753087 0.736489403701143 -0.0693210605039065 Nonsignificant None -- -- -- -- -- -- -- -- A0A1Y7VKC0 Mediator of RNA polymerase II transcription subunit 10 (Fragment) Med10 110.3 108.5 144.8 146.3 146.8 108 0.906507105459985 0.513481233148573 -0.141609766620402 Nonsignificant None 3 Molecular Function:RNA polymerase II transcription cofactor activity (GO:0001104),Biological Process:regulation of transcription from RNA polymerase II promoter (GO:0006357),Cellular Component:mediator complex (GO:0016592) mediator of RNA polymerase II transcription subunit 10 -- -- Transcription factor, subunit of SRB subcomplex of RNA polymerase II K Transcription ; IPR019145 [Mediator complex, subunit Med10] -- -- G3EB90 NADH-ubiquinone oxidoreductase chain 1 ND1 293.3 280.6 237.1 263.6 237.4 295.5 1.01820464532329 0.849675795572776 0.0260275526919635 Nonsignificant None 2 Cellular Component:membrane (GO:0016020),Biological Process:oxidation-reduction process (GO:0055114) NADH-ubiquinone oxidoreductase chain 1 1.6.5.3 ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko05012 Parkinson's disease NADH dehydrogenase subunit 1 C Energy production and conversion ; IPR001694 [NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H] -- -- A0A1Y7VJI5 WD repeat domain 20, retrogene (Fragment) Wdr20rt 39.2 28.1 26.7 28.1 33.3 35.9 0.966084275436794 0.821651685651096 -0.0497790482161115 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- WD40 protein DMR-N9 R General function prediction only ; IPR001680 [WD40 repeat] -- -- Q9D4H2 GRIP and coiled-coil domain-containing protein 1 Gcc1 94.1 78.2 109.6 113 109.7 98.5 0.877646326276463 0.263208486679672 -0.188288414946893 Nonsignificant None 2 Biological Process:protein targeting to Golgi (GO:0000042),Molecular Function:protein binding (GO:0005515) GRIP and coiled-coil domain-containing protein 1 -- -- -- -- -- IPR000237 [GRIP domain] -- -- A0A075F6C2 Heat shock transcription factor 1 gammaalpha isoform Hsf1 43.8 39.7 46.7 35 48 47.9 0.994652406417112 0.963334572765104 -0.00773564877960531 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634),Molecular Function:sequence-specific DNA binding (GO:0043565) heat shock transcription factor 1 -- ko05134 Legionellosis Heat shock transcription factor K Transcription ; IPR000232 [Heat shock factor (HSF)-type, DNA-binding] ; IPR010542[Vertebrate heat shock transcription factor, C-terminal domain] -- HSF Q9CRQ7 Uncharacterized protein (Fragment) Rabgap1l 81.3 76 97.5 101.8 103.4 102.8 0.827272727272727 0.110482663236805 -0.273565073325963 Nonsignificant None -- -- Rab GTPase-activating protein 1 -- -- Rab6 GTPase activator GAPCenA and related TBC domain proteins R General function prediction only ; -- -- -- P62340 TATA box-binding protein-like 1 Tbpl1 26.9 33.3 26.1 25.8 30.4 27.9 1.02615933412604 0.794796397323991 0.0372547589238108 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) transcription initiation factor TFIID TATA-box-binding protein -- ko03022 Basal transcription factors ko05016 Huntington's disease ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection ko05203 Viral carcinogenesis TATA-box binding protein (TBP), component of TFIID and TFIIIB K Transcription ; IPR000814 [TATA-box binding protein] -- -- Q8BH35 Complement component C8 beta chain C8b 46.1 37.6 33.8 37.5 38.8 44.2 0.975103734439834 0.822465893978665 -0.0363723896649619 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) complement component 8 subunit beta -- ko04610 Complement and coagulation cascades ko05020 Prion diseases ko05146 Amoebiasis ko05322 Systemic lupus erythematosus -- -- -- IPR000884 [Thrombospondin type-1 (TSP1) repeat] ; IPR002172[Low-density lipoprotein (LDL) receptor class A repeat] ; IPR020864[Membrane attack complex component/perforin (MACPF) domain] -- -- Q8BTX9 Inactive hydroxysteroid dehydrogenase-like protein 1 Hsdl1 92 79.1 59.6 54.8 56.5 70.1 1.27177508269019 0.195636241660723 0.346843548154461 Nonsignificant None -- -- -- -- -- 17 beta-hydroxysteroid dehydrogenase type 3, HSD17B3 I Lipid transport and metabolism ; IPR002347 [Short-chain dehydrogenase/reductase SDR] -- -- Q921C3 Bromodomain and WD repeat-containing protein 1 Brwd1 48.5 45.4 40.7 36 37.2 31.8 1.28190476190476 0.0242729139400405 0.358289082056832 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) bromodomain and WD repeat domain containing protein 1/3 -- -- Uncharacterized conserved protein, contains WD40 repeat and BROMO domains R General function prediction only ; IPR001487 [Bromodomain] ; IPR001680[WD40 repeat] -- -- F6YCH1 Wings apart-like protein homolog (Fragment) Wapl 169.7 166 151.9 147.2 137.1 143.4 1.14005143792378 0.0318085764870395 0.189098918743878 Nonsignificant None -- -- -- -- -- Sister chromatid cohesion protein D Cell cycle control, cell division, chromosome partitioning ; IPR022771 [Wings apart-like protein] -- -- A0A2I3BPQ0 Receptor-binding cancer antigen-expressed on SiSo cells (Fragment) Ebag9 24.4 19.8 17.9 24 20.2 17 1.01470588235294 0.919715470645696 0.0210616155278296 Nonsignificant None -- -- -- -- -- -- -- -- D3YWS8 Leukocyte receptor cluster member 8 homolog Leng8 71.6 61.9 50.3 54.5 62.9 64.8 1.00878155872667 0.94228948035173 0.0126138074869837 Nonsignificant None -- -- -- -- -- Leucine permease transcriptional regulator K Transcription ; IPR005062 [SAC3/GANP/THP3] -- -- Q3U3Q7 Angiotensin-converting enzyme Ace 127.6 107 119.8 110.9 111.9 114.9 1.04945217648801 0.414763773240967 0.0696364245475414 Nonsignificant None 4 Biological Process:proteolysis (GO:0006508),Molecular Function:metallopeptidase activity (GO:0008237),Molecular Function:peptidyl-dipeptidase activity (GO:0008241),Cellular Component:membrane (GO:0016020) peptidyl-dipeptidase A 3.4.15.1 ko04614 Renin-angiotensin system ko04924 Renin secretion ko05142 Chagas disease (American trypanosomiasis) ko05410 Hypertrophic cardiomyopathy (HCM) Angiotensin I-converting enzymes - M2 family peptidases E Amino acid transport and metabolism ; IPR001548 [Peptidase M2, peptidyl-dipeptidase A] -- -- A6H6E2 Multimerin-2 Mmrn2 103.6 99.6 80.8 93.2 73.6 101 1.0604929051531 0.642213461328358 0.0847349690677336 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR001073 [C1q domain] ; IPR011489[EMI domain] -- -- A0A571BEH9 Rho guanine nucleotide exchange factor 28 Arhgef28 21.1 18.4 17.9 19.9 26.1 20.2 0.867069486404834 0.262291983057276 -0.20578048013153 Nonsignificant None 3 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Biological Process:regulation of Rho protein signal transduction (GO:0035023),Biological Process:intracellular signal transduction (GO:0035556) A-kinase anchor protein 28 -- -- Predicted guanine nucleotide exchange factor T Signal transduction mechanisms ; IPR000219 [Dbl homology (DH) domain] ; IPR002219[Protein kinase C-like, phorbol ester/diacylglycerol-binding domain] -- -- Q3URM1 Uncharacterized protein Clpb 265.3 217.5 181.3 231 212 212.7 1.01281073661736 0.916578227832319 0.0183646037004884 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) ATP-dependent Clp protease ATP-binding subunit ClpB -- ko04213 Longevity regulating pathway - multiple species Chaperone HSP104 and related ATP-dependent Clp proteases O Posttranslational modification, protein turnover, chaperones ; IPR003959 [ATPase, AAA-type, core] ; IPR019489[Clp ATPase, C-terminal] ; IPR020683[Ankyrin repeat-containing domain] -- -- Q8VHL1 Histone-lysine N-methyltransferase SETD7 Setd7 467.6 507.6 481.9 459.4 464.2 420.3 1.08423245777216 0.106450305479303 0.116674101453402 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) histone-lysine N-methyltransferase SETD7 2.1.1.43 ko00310 Lysine degradation ko04068 FoxO signaling pathway Transcriptional repressor EZH1 K Transcription ; IPR001214 [SET domain] ; IPR003409[MORN motif] -- -- A0A0R4J0G4 Ran-binding protein 10 Ranbp10 73.7 74.5 56.6 62.3 63.1 64.3 1.07959936742225 0.479807666575318 0.110496036588524 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- SPRY domain-containing proteins R General function prediction only ; IPR003877 [SPRY domain] ; IPR006594[LIS1 homology motif] ; IPR024964[CTLH/CRA C-terminal to LisH motif domain] -- -- Q80X73 Protein pelota homolog Pelo 643.1 617.4 544.3 488.1 502.9 515.4 1.19808815719596 0.0314500412346761 0.260734067784565 Nonsignificant None -- -- protein pelota -- ko03015 mRNA surveillance pathway Meiotic cell division protein Pelota/DOM34 J Translation, ribosomal structure and biogenesis ; IPR005140 [eRF1 domain 1/Pelota-like] ; IPR005141[eRF1 domain 2] ; IPR005142[eRF1 domain 3] -- -- D3YXJ5 LRAT domain-containing 1 Lratd2 172.2 162.9 191.2 178.1 194.5 195.4 0.926584507042253 0.238763831626591 -0.110005534899271 Nonsignificant None -- -- -- -- -- -- -- -- IPR007053 [LRAT-like domain] -- -- O35601 FYN-binding protein 1 Fyb1 166.5 170.4 169.8 211.5 198 199.6 0.831883106222295 0.00152381678987687 -0.265547275561134 Nonsignificant None -- -- FYN binding protein -- ko04015 Rap1 signaling pathway -- -- -- IPR011511 [Variant SH3 domain] ; IPR029294[Helically-extended SH3 domain] -- -- A3KGL0 Alkyl transferase Dhdds 110.6 105.6 101.4 73.3 96.6 98.3 1.18419090231171 0.124509654476023 0.243901675238484 Nonsignificant None -- -- ditrans,polycis-polyprenyl diphosphate synthase 2.5.1.87 ko00900 Terpenoid backbone biosynthesis Cis-prenyltransferase I Lipid transport and metabolism ; IPR001441 [Decaprenyl diphosphate synthase-like] -- -- A0A494BA07 Geranylgeranyl transferase type-1 subunit beta Pggt1b 235 255.8 285.5 268 242 274.6 0.989421361203161 0.883443908847118 -0.0153430478577817 Nonsignificant None 1 Molecular Function:catalytic activity (GO:0003824) geranylgeranyl transferase type-1 subunit beta 2.5.1.59 -- Protein geranylgeranyltransferase Type I, beta subunit O Posttranslational modification, protein turnover, chaperones ; IPR001330 [PFTB repeat] -- -- B2RTE5 Coiled-coil domain containing 102A Ccdc102a 56.5 51.1 55.8 53.1 40.7 45.8 1.17048710601719 0.116855644935738 0.227109041936031 Nonsignificant None 2 Molecular Function:motor activity (GO:0003774),Cellular Component:myosin complex (GO:0016459) coiled-coil domain-containing protein 102A -- -- -- -- -- IPR002928 [Myosin tail] -- -- A0A0U1RNS1 SAGA-associated factor 29 (Fragment) Sgf29 99.1 86.8 102.2 100.7 108.9 109.7 0.902286251174444 0.132255613840732 -0.148342892410223 Nonsignificant None -- -- SAGA-associated factor 29 -- -- Histone acetyltransferase SAGA associated factor SGF29 R General function prediction only ; IPR010750 [SGF29 tudor-like domain] -- -- A3KME9 Padi2 protein (Fragment) Padi2 18.2 19 14.3 16.5 15.8 17.1 1.04251012145749 0.664946165551829 0.0600613904859031 Nonsignificant None 3 Molecular Function:protein-arginine deiminase activity (GO:0004668),Molecular Function:calcium ion binding (GO:0005509),Cellular Component:cytoplasm (GO:0005737) protein-arginine deiminase 3.5.3.15 -- -- -- -- IPR013530 [Protein-arginine deiminase, C-terminal] -- -- G3UWE3 E3 SUMO-protein ligase PIAS2 Pias2 55.1 51.4 54.7 67.6 60.2 68.8 0.819938962360122 0.0158320131591594 -0.286411577812613 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) E3 SUMO-protein ligase PIAS2 -- ko04120 Ubiquitin mediated proteolysis ko04630 Jak-STAT signaling pathway Zn-finger transcription factor K Transcription ; IPR004181 [Zinc finger, MIZ-type] ; IPR023321[PINIT domain] -- zf-MIZ Q99LS3 Phosphoserine phosphatase Psph 289.2 252 287.9 282.3 274.7 290.2 0.978635505193579 0.666343540232133 -0.0311564697523225 Nonsignificant None -- -- phosphoserine phosphatase 3.1.3.3 ko00260 Glycine, serine and threonine metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01230 Biosynthesis of amino acids Phosphoserine phosphatase E Amino acid transport and metabolism ; -- -- -- A0A1B0GT74 LETM1 domain-containing protein LETM2, mitochondrial Letm2 125.3 126.8 106.3 98.9 182 136.6 0.858443113772455 0.473327111790115 -0.220205560191173 Nonsignificant None -- -- -- -- -- Ca2+-binding transmembrane protein LETM1/MRS7 S Function unknown ; IPR011685 [LETM1-like] -- -- F6VBV0 Regulating synaptic membrane exocytosis protein 1 Rims1 29.2 28.2 30.8 41.3 39.9 34.4 0.762975778546713 0.0150813672774268 -0.390290836943158 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) regulating synaptic membrane exocytosis protein 1 -- ko04721 Synaptic vesicle cycle ko04723 Retrograde endocannabinoid signaling Rab3 effector RIM1 and related proteins, contain PDZ and C2 domains U Intracellular trafficking, secretion, and vesicular transport ; IPR000008 [C2 domain] ; IPR001478[PDZ domain] ; IPR011011[Zinc finger, FYVE/PHD-type] -- -- F7CGC9 DnaJ homolog subfamily C member 24 (Fragment) Dnajc24 205.7 216.3 217.1 193.1 216.9 210.7 1.0296439503786 0.4870142169106 0.0421455414606604 Nonsignificant None -- -- diphthamide biosynthesis protein 4 -- -- Molecular chaperone (DnaJ superfamily) O Posttranslational modification, protein turnover, chaperones ; IPR001623 [DnaJ domain] ; IPR007872[Zinc finger, DPH-type] -- -- Q91Z67 SLIT-ROBO Rho GTPase-activating protein 2 Srgap2 348.7 315.4 236.3 236.1 242.3 278 1.19037546271814 0.251056756846915 0.251416693504394 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Biological Process:signal transduction (GO:0007165) SLIT-ROBO Rho GTPase activating protein -- ko04360 Axon guidance Cdc42-interacting protein CIP4 Z Cytoskeleton ; IPR000198 [Rho GTPase-activating protein domain] ; IPR001060[FCH domain] ; IPR001452[SH3 domain] -- -- A0A6G7MAJ9 Xaf1 Xaf1 28.6 31.3 22 20.6 21.9 23.8 1.23529411764706 0.148938748431745 0.304854581528421 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- H3BJJ4 G/T mismatch-specific thymine DNA glycosylase (Fragment) Tdg 179.4 307.3 350.6 403.2 375.7 241.8 0.820319388654845 0.441322536764872 -0.285742367211342 Nonsignificant None -- -- thymine-DNA glycosylase 3.2.2.29 ko03410 Base excision repair G/T mismatch-specific thymine DNA glycosylase L Replication, recombination and repair ; -- -- -- Q05CN2 Rrp1 protein Rrp1 97.8 100.7 89.3 76.7 87.4 86.1 1.15027977617906 0.0594370292008812 0.201984802574478 Nonsignificant None 1 Biological Process:rRNA processing (GO:0006364) ribosomal RNA-processing protein 1 -- -- Nucleolar protein NOP52/RRP1 A RNA processing and modification ; IPR010301 [Nucleolar, Nop52] -- -- Q8VCC9 Spondin-1 Spon1 249.3 257.9 216.2 232 237.4 240.9 1.01844291144587 0.753327733423519 0.0263651126727087 Nonsignificant None -- -- -- -- -- Spondins, extracellular matrix proteins W Extracellular structures ; IPR000884 [Thrombospondin type-1 (TSP1) repeat] ; IPR002861[Reeler domain] ; IPR009465[Spondin, N-terminal] -- -- Q8BVW0 Neutral alpha-glucosidase C Ganc 37.1 41 49.7 60.6 71 61.3 0.662519440124417 0.0123645724065195 -0.593965307102109 Significant down 1 Biological Process:carbohydrate metabolic process (GO:0005975) neutral alpha-glucosidase C 3.2.1.20 ko00052 Galactose metabolism ko00500 Starch and sucrose metabolism ko01100 Metabolic pathways Glucosidase II catalytic (alpha) subunit and related enzymes, glycosyl hydrolase family 31 GMO Carbohydrate transport and metabolism ; Cell wall/membrane/envelope biogenesis ; Posttranslational modification, protein turnover, chaperones ; IPR000322 [Glycoside hydrolase family 31] ; IPR025887[Glycoside hydrolase family 31, N-terminal domain] -- -- A0A087WS40 Voltage-dependent L-type calcium channel subunit alpha Cacna1c 30.7 34.2 21.2 36.6 37 33.7 0.80242311276794 0.153636351909276 -0.317564933359678 Nonsignificant None 4 Molecular Function:ion channel activity (GO:0005216),Biological Process:ion transport (GO:0006811),Cellular Component:membrane (GO:0016020),Biological Process:transmembrane transport (GO:0055085) voltage-dependent calcium channel L type alpha-1C -- ko04010 MAPK signaling pathway ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04260 Cardiac muscle contraction ko04261 Adrenergic signaling in cardiomyocytes ko04270 Vascular smooth muscle contraction ko04713 Circadian entrainment ko04720 Long-term potentiation ko04723 Retrograde endocannabinoid signaling ko04724 Glutamatergic synapse ko04725 Cholinergic synapse ko04726 Serotonergic synapse ko04727 GABAergic synapse ko04728 Dopaminergic synapse ko04742 Taste transduction ko04911 Insulin secretion ko04912 GnRH signaling pathway ko04921 Oxytocin signaling pathway ko04924 Renin secretion ko04925 Aldosterone synthesis and secretion ko04930 Type II diabetes mellitus ko05010 Alzheimer's disease ko05031 Amphetamine addiction ko05410 Hypertrophic cardiomyopathy (HCM) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05414 Dilated cardiomyopathy (DCM) Voltage-gated Ca2+ channels, alpha1 subunits PT Inorganic ion transport and metabolism ; Signal transduction mechanisms ; IPR005821 [Ion transport domain] ; IPR014873[Voltage-dependent calcium channel, alpha-1 subunit, IQ domain] ; IPR031649[Voltage-dependent L-type calcium channel, IQ-associated domain] ; IPR031688[Voltage-gated calcium channel subunit alpha, C-terminal] -- -- G3UZG5 Kelch domain-containing protein 4 Klhdc4 127.4 132.2 95.1 67 77.3 72.8 1.63380930446799 0.0188696513560428 0.708239604320045 Significant up 1 Molecular Function:protein binding (GO:0005515) -- -- -- Protein containing repeated kelch motifs R General function prediction only ; IPR011498 [Kelch repeat type 2] -- -- A0A2R8VHV7 Alanine transaminase (Fragment) Gpt 116.9 136.5 193.4 208.2 201.3 203.6 0.728755504811613 0.135890932403786 -0.456493218825453 Nonsignificant None 2 Biological Process:biosynthetic process (GO:0009058),Molecular Function:pyridoxal phosphate binding (GO:0030170) alanine transaminase 2.6.1.2 ko00220 Arginine biosynthesis ko00250 Alanine, aspartate and glutamate metabolism ko01100 Metabolic pathways ko01200 Carbon metabolism ko01210 2-Oxocarboxylic acid metabolism ko01230 Biosynthesis of amino acids Alanine aminotransferase E Amino acid transport and metabolism ; IPR004839 [Aminotransferase, class I/classII] -- -- Q6KAQ0 MFLJ00211 protein (Fragment) Nsmce3 183.4 198.9 149.7 143.9 136.9 142.3 1.25738596076578 0.126813904040981 0.330427560032202 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein (tumor-rejection antigen MAGE in humans) S Function unknown ; IPR002190 [MAGE homology domain] -- -- Q6P1H6 Ankyrin repeat and LEM domain-containing protein 2 Ankle2 64.1 77.1 84.3 96.3 87.6 88.1 0.829044117647059 0.0770980038386141 -0.270479217994959 Nonsignificant None -- -- ankyrin repeat and LEM domain-containing protein 2 -- -- -- -- -- IPR003887 [LEM domain] -- -- Q5F2E7 FMR1-interacting protein NUFIP2 Nufip2 49.7 35.3 29.9 38.1 34 32 1.10374639769452 0.591241754051878 0.142408729346696 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) -- -- -- -- -- -- IPR032747 [Nuclear fragile X mental retardation-interacting protein 2] -- -- Q91W72 Maged1 protein Maged1 54.1 58.8 65.9 57 61.1 53.6 1.04135119394292 0.591019729610824 0.0584566971811835 Nonsignificant None -- -- melanoma-associated antigen D1 -- ko04722 Neurotrophin signaling pathway Uncharacterized conserved protein (tumor-rejection antigen MAGE in humans) S Function unknown ; -- -- -- A0A286YDV6 Zinc transporter Slc30a5 59.5 63.2 67.3 72.7 67.9 68.4 0.909090909090909 0.0803507018393869 -0.137503523749935 Nonsignificant None 4 Biological Process:cation transport (GO:0006812),Molecular Function:cation transmembrane transporter activity (GO:0008324),Cellular Component:integral component of membrane (GO:0016021),Biological Process:transmembrane transport (GO:0055085) solute carrier family 30 (zinc transporter), member 5/7 -- -- Putative Zn2+ transporter MSC2 (cation diffusion facilitator superfamily) P Inorganic ion transport and metabolism ; IPR002524 [Cation efflux protein] -- -- O88935 Synapsin-1 Syn1 45.6 37.2 67 80.6 85.6 90.8 0.582879377431907 0.0187313588308856 -0.778730735622489 Significant down -- -- synapsin -- -- Synaptic vesicle protein Synapsin TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR019736 [Synapsin, phosphorylation site] ; IPR020897[Synapsin, pre-ATP-grasp domain] ; IPR020898[Synapsin, ATP-binding domain] -- -- Q8C3W1 Uncharacterized protein C1orf198 homolog 263 336.9 201.9 209.6 208.3 226.9 1.24348635235732 0.311140975406676 0.314390673622803 Nonsignificant None -- -- -- -- -- -- -- -- IPR031600 [Domain of unknown function DUF4706] -- -- A2A6Q5 Cell division cycle protein 27 homolog Cdc27 131.9 131.6 164.3 161 145.9 153.8 0.928586932928153 0.401432469818828 -0.106891115439167 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) anaphase-promoting complex subunit 3 -- ko04110 Cell cycle ko04114 Oocyte meiosis ko04120 Ubiquitin mediated proteolysis ko04914 Progesterone-mediated oocyte maturation ko05166 HTLV-I infection DNA-binding cell division cycle control protein D Cell cycle control, cell division, chromosome partitioning ; IPR001440 [Tetratricopeptide repeat 1] ; IPR019734[Tetratricopeptide repeat] -- -- F8WHT5 Protein Mpv17 Mpv17 315.7 326.7 306.1 299.2 296.8 326.6 1.02807283763278 0.485984864515812 0.0399424812331823 Nonsignificant None -- -- protein Mpv17 -- ko04146 Peroxisome Peroxisomal membrane protein MPV17 and related proteins R General function prediction only ; -- -- -- D3Z7C3 2-phosphoxylose phosphatase 1 (Fragment) Pxylp1 43 44.9 39 42.9 55.9 38.5 0.924253459577567 0.563066991544353 -0.113639556305995 Nonsignificant None 1 Molecular Function:acid phosphatase activity (GO:0003993) 2-phosphoxylose phosphatase 3.1.3.- -- Histidine acid phosphatase R General function prediction only ; IPR000560 [Histidine phosphatase superfamily, clade-2] -- -- Q3US24 Uncharacterized protein Bach1 124.6 144.7 136.8 145.5 154.2 139.1 0.925478577939836 0.209825190913571 -0.111728498478867 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Molecular Function:protein binding (GO:0005515),Cellular Component:nucleus (GO:0005634) transcription regulator BACH -- -- bZIP transcription factor NRF1 K Transcription ; IPR000210 [BTB/POZ domain] ; IPR004826[Basic leucine zipper domain, Maf-type] -- ZBTB A0A172Q395 CUB domain-containing protein 1 (Fragment) Cdcp1 417.3 395.4 413.2 382.6 390.8 402.7 1.04234333815152 0.13562177963236 0.0598305661583385 Nonsignificant None -- -- CUB domain-containing protein 1 -- -- -- -- -- -- -- -- Q8VDM1 Zinc finger CCCH-type with G patch domain-containing protein Zgpat 150.4 130.2 200 165.9 166.5 171.1 0.954518371400198 0.748453673453429 -0.067155129764281 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- Predicted RNA-processing protein, contains G-patch domain A RNA processing and modification ; IPR000467 [G-patch domain] -- -- Q8BJB5 Thrombomodulin (Fragment) 143.7 132.4 150.3 156.5 171.1 187.9 0.827158098933075 0.0470203435318248 -0.273764989496295 Nonsignificant None 3 Molecular Function:transmembrane signaling receptor activity (GO:0004888),Molecular Function:calcium ion binding (GO:0005509),Cellular Component:integral component of membrane (GO:0016021) thrombomodulin -- ko04610 Complement and coagulation cascades ko04933 AGE-RAGE signaling pathway in diabetic complications ko05418 Fluid shear stress and atherosclerosis -- -- -- IPR001304 [C-type lectin-like] ; IPR001881[EGF-like calcium-binding domain] ; IPR015149[Thrombomodulin-like, EGF-like] -- -- A0A1L1SUM1 Transmembrane protein 45B (Fragment) Tmem45b 246.4 193.2 162.9 265.4 267.7 253.1 0.766344441617909 0.0691763919610981 -0.383935122419408 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- P62274 40S ribosomal protein S29 Rps29 1094.4 1040.8 861.4 903.5 858.7 898.6 1.12620264582081 0.19434881618224 0.171466445372206 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S29e -- ko03010 Ribosome 40S ribosomal protein S29 J Translation, ribosomal structure and biogenesis ; IPR001209 [Ribosomal protein S14] -- -- Q8VEB3 Macrophage immunometabolism regulator MACIR 95.8 109.6 91.2 106.4 107.1 97.2 0.954618603154168 0.502360200732828 -0.0670036436672102 Nonsignificant None -- -- -- -- -- -- -- -- IPR029219 [UNC119-binding protein] -- -- F6TZU3 Gigaxonin (Fragment) Gan 17.1 16.9 8.5 16.3 13.4 19.7 0.860323886639676 0.532208888222821 -0.217048200559614 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) kelch-like protein 16 (gigaxonin) -- -- Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes TR Signal transduction mechanisms ; General function prediction only ; IPR000210 [BTB/POZ domain] ; IPR006652[Kelch repeat type 1] ; IPR011705[BTB/Kelch-associated] -- ZBTB Q3UV84 Uncharacterized protein (Fragment) Ncoa3 28.4 27.3 16.2 27.5 23.4 26.6 0.927741935483871 0.67179377841238 -0.108204539722302 Nonsignificant None -- -- nuclear receptor coactivator 3 2.3.1.48 ko01522 Endocrine resistance ko04919 Thyroid hormone signaling pathway ko05200 Pathways in cancer ko05224 Breast cancer Aryl-hydrocarbon receptor nuclear translocator K Transcription ; IPR013767 [PAS fold] -- -- Q9D236 Serine protease HTRA3 Htra3 14.3 14 14.3 10.6 12.9 10.9 1.23837209302326 0.0606463674485472 0.30844486552374 Nonsignificant None 4 Biological Process:regulation of cell growth (GO:0001558),Molecular Function:protein binding (GO:0005515),Molecular Function:insulin-like growth factor binding (GO:0005520),Cellular Component:extracellular region (GO:0005576) HtrA serine peptidase 3 3.4.21.- -- -- -- -- IPR000867 [Insulin-like growth factor-binding protein, IGFBP] ; IPR001478[PDZ domain] ; IPR002350[Kazal domain] -- -- Q3UFS0 Protein zyg-11 homolog B Zyg11b 41.6 40.9 37.9 32.6 26.5 34 1.29323308270677 0.0239023720359638 0.370982319200908 Nonsignificant None -- -- Zyg-11 protein homolog -- -- ZYG-1-like serine/threonine protein kinases R General function prediction only ; -- -- -- E9PUK3 Formin-binding protein 1-like Fnbp1l 58 57.1 67.3 66.4 52.1 71.6 0.959495002630195 0.720345664565422 -0.0596528024838104 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) formin-binding protein 1 -- -- Cdc42-interacting protein CIP4 Z Cytoskeleton ; IPR001060 [FCH domain] ; IPR001452[SH3 domain] -- -- P70665 Sialate O-acetylesterase Siae 451.8 608.8 545.4 454.7 399.3 468 1.21482602118003 0.132502379421634 0.280749716009623 Nonsignificant None -- -- sialate O-acetylesterase 3.1.1.53 -- -- -- -- IPR005181 [Sialate O-acetylesterase domain] -- -- Q91W18 Tudor domain-containing protein 3 Tdrd3 125.1 140.6 147 154.1 193.6 151.5 0.826722756410256 0.128685178697086 -0.274524495855214 Nonsignificant None 4 Molecular Function:RNA binding (GO:0003723),Cellular Component:nucleus (GO:0005634),Cellular Component:cytoplasm (GO:0005737),Biological Process:mRNA processing (GO:0006397) tudor domain-containing protein 3 -- -- Uncharacterized conserved protein S Function unknown ; IPR010304 [Survival motor neuron] ; IPR013894[RecQ mediated genome instability protein, N-terminal] ; IPR015940[Ubiquitin-associated domain] -- -- Q9D1H8 39S ribosomal protein L53, mitochondrial Mrpl53 178.3 168.9 184.1 171.2 193.6 196.9 0.94587858287342 0.332894281838347 -0.08027309010554 Nonsignificant None -- -- large subunit ribosomal protein L53 -- -- -- -- -- IPR019716 [Ribosomal protein L53, mitochondrial] -- -- Q3TYA4 Syntaxin-binding protein 6 Stxbp6 139.6 128.5 144.5 139.2 146.1 154.4 0.938367068455765 0.23445251477808 -0.0917757113261624 Nonsignificant None 2 Cellular Component:integral component of membrane (GO:0016021),Biological Process:vesicle-mediated transport (GO:0016192) syntaxin-binding protein 6 -- -- Tomosyn and related SNARE-interacting proteins U Intracellular trafficking, secretion, and vesicular transport ; IPR001388 [Synaptobrevin] ; IPR028258[Exocyst complex component Sec3, PIP2-binding N-terminal domain] -- -- Q9CY94 DNA replication complex GINS protein PSF3 Gins3 291.3 264.1 237.1 218.4 241.4 235.3 1.14012372320529 0.130306115978945 0.189190390328154 Nonsignificant None -- -- GINS complex subunit 3 -- -- Uncharacterized conserved protein S Function unknown ; IPR021151 [GINS subunit, domain A] -- -- G3UY57 Tripartite motif-containing 15 Trim15 170.8 173.8 152.8 143.9 126.8 142.9 1.20261121856867 0.0312644079789571 0.266170321901972 Nonsignificant None 3 Cellular Component:intracellular (GO:0005622),Molecular Function:zinc ion binding (GO:0008270),Molecular Function:metal ion binding (GO:0046872) tripartite motif-containing protein 15 -- -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR000315 [B-box-type zinc finger] ; IPR018957[Zinc finger, C3HC4 RING-type] -- -- Q3UHC1 Rap guanine nucleotide exchange factor (GEF) 1 Rapgef1 127.9 118.6 127.5 149.8 134.5 128.5 0.906007751937985 0.139652118621537 -0.142404700648255 Nonsignificant None 2 Molecular Function:guanyl-nucleotide exchange factor activity (GO:0005085),Biological Process:small GTPase mediated signal transduction (GO:0007264) Rap guanine nucleotide exchange factor 1 -- ko04015 Rap1 signaling pathway ko04510 Focal adhesion ko04722 Neurotrophin signaling pathway ko04910 Insulin signaling pathway ko05211 Renal cell carcinoma Ras1 guanine nucleotide exchange factor T Signal transduction mechanisms ; IPR000651 [Ras-like guanine nucleotide exchange factor, N-terminal] ; IPR001895[Ras guanine-nucleotide exchange factors catalytic domain] -- -- Q8R2I1 GDP-fucose transporter 1 Slc35c1 177.4 157.5 193.2 220.6 230 225.8 0.780751034890597 0.00981806859825105 -0.357065518338545 Nonsignificant None -- -- solute carrier family 35 (GDP-fucose transporter), member C1 -- -- GDP-fucose transporter GOU Carbohydrate transport and metabolism ; Posttranslational modification, protein turnover, chaperones ; Intracellular trafficking, secretion, and vesicular transport ; IPR004853 [Sugar phosphate transporter domain] -- -- A0A075DCW1 NADH-ubiquinone oxidoreductase chain 3 ND3 60.5 57.4 56.6 66.3 79.5 88.2 0.745726495726496 0.0375712744256622 -0.423281493373752 Nonsignificant None 2 Molecular Function:NADH dehydrogenase (ubiquinone) activity (GO:0008137),Biological Process:oxidation-reduction process (GO:0055114) NADH-ubiquinone oxidoreductase chain 3 1.6.5.3 ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko05012 Parkinson's disease NADH dehydrogenase subunit 3 and related proteins C Energy production and conversion ; IPR000440 [NADH:ubiquinone/plastoquinone oxidoreductase, chain 3] -- -- B1ARG9 Telomerase-binding protein EST1A (Fragment) Smg6 14.8 17.4 24.5 18.3 28 16.3 0.905750798722045 0.692998150352969 -0.14281392199039 Nonsignificant None -- -- protein SMG6 3.1.-.- ko03015 mRNA surveillance pathway Nonsense-mediated mRNA decay protein A RNA processing and modification ; IPR018834 [DNA/RNA-binding domain, Est1-type] -- -- Q99LI9 Polyribonucleotide 5-hydroxyl-kinase Clp1 Clp1 127.5 137.3 151.4 138.8 143.7 138.3 0.989068441064639 0.840621883093069 -0.0158577395569677 Nonsignificant None 1 Biological Process:mRNA 3'-end processing (GO:0031124) polyribonucleotide 5'-hydroxyl-kinase 2.7.1.78 ko03015 mRNA surveillance pathway mRNA cleavage and polyadenylation factor IA/II complex, subunit CLP1 A RNA processing and modification ; IPR010655 [Pre-mRNA cleavage complex subunit Clp1] ; IPR032319[Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain] ; IPR032324[Clp1, N-terminal beta-sandwich domain] -- -- E9PYP1 Carboxylic ester hydrolase Ces1a 79.4 76.1 106.9 127.6 126 109.5 0.722665932250069 0.0416452461559577 -0.468599210182123 Nonsignificant None -- -- -- -- -- Carboxylesterase and related proteins R General function prediction only ; IPR002018 [Carboxylesterase, type B] -- -- Q9CPW9 Methionine aminopeptidase 1D, mitochondrial Metap1d 64.2 61.4 56 88.9 81.7 80.9 0.7220675944334 0.00264938029849568 -0.469794197401975 Nonsignificant None -- -- methionyl aminopeptidase 3.4.11.18 -- Putative methionine aminopeptidase O Posttranslational modification, protein turnover, chaperones ; IPR000994 [Peptidase M24] -- -- Q9JMK0 Beta-1,4-galactosyltransferase 5 B4galt5 28.8 32.9 25.6 35 26.5 34.3 0.911273486430063 0.457311067756206 -0.13404400210674 Nonsignificant None -- -- beta-1,4-galactosyltransferase 5 2.4.1.- ko00512 Mucin type O-glycan biosynthesis UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase G Carbohydrate transport and metabolism ; IPR027791 [Galactosyltransferase, C-terminal] ; IPR027995[Galactosyltransferase, N-terminal] -- -- Q8BYY2 RFX-type winged-helix domain-containing protein (Fragment) Rfx1 112.4 106.9 116.5 118 129 134.5 0.880209698558322 0.0527419201642683 -0.184080826784863 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634) regulatory factor X 1/2/3 -- -- RFX family transcription factor K Transcription ; IPR003150 [DNA-binding RFX-type winged-helix domain] ; IPR007668[RFX1 transcription activation region] -- RFX E9PX46 Epsilon-sarcoglycan Sgce 141 158.9 213.2 251 219.7 242.2 0.719736288399495 0.0478647995450024 -0.474459695428599 Nonsignificant None 1 Cellular Component:sarcoglycan complex (GO:0016012) -- -- -- Sarcoglycan complex, alpha/epsilon subunits S Function unknown ; IPR008908 [Sarcoglycan alpha/epsilon] -- -- Q8K194 U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein Snrnp27 129.9 125.4 96.7 108.5 98.4 100.7 1.1443433029909 0.24382525001842 0.194519925562833 Nonsignificant None -- -- U4/U6.U5 tri-snRNP-associated protein 3 -- ko03040 Spliceosome Nucleic acid binding protein R General function prediction only ; IPR013957 [Domain of unknown function DUF1777] -- -- Q8K3P5 CCR4-NOT transcription complex subunit 6 Cnot6 39.1 29.1 41.2 45.2 41.2 42.9 0.846094354215004 0.164918800471534 -0.241109537017698 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) CCR4-NOT transcription complex subunit 6 3.1.13.4 ko03018 RNA degradation Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins K Transcription ; IPR001611 [Leucine-rich repeat] ; IPR005135[Endonuclease/exonuclease/phosphatase] -- -- A0A3B2WB50 EMILIN-2 Emilin2 334.5 408.4 224.7 373.1 386.6 309 0.905399082998035 0.595358455192781 -0.143374249484355 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR001073 [C1q domain] ; IPR011489[EMI domain] -- -- D3YU00 StAR-related lipid transfer protein 5 Stard5 173.3 164.3 220.1 192.7 191.7 206.5 0.943814520223388 0.570768915173025 -0.0834247279335502 Nonsignificant None 1 Molecular Function:lipid binding (GO:0008289) -- -- -- MLN, STAR and related lipid-binding proteins I Lipid transport and metabolism ; IPR002913 [START domain] -- -- P28184 Metallothionein-3 Mt3 82.9 91.7 211.6 202.7 177.4 191 0.676238837331466 0.217492600215465 -0.564395220305697 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) metallothionein 3 -- -- Predicted metallothionein P Inorganic ion transport and metabolism ; IPR003019 [Metallothionein] -- -- Q9CWI3 BRCA2 and CDKN1A-interacting protein Bccip 79.1 65.3 80.5 80.6 79.7 69.8 0.977401129943503 0.785560086523151 -0.0329773224462728 Nonsignificant None -- -- protein BCP1 -- -- Isoamyl acetate-hydrolyzing esterase and related enzymes R General function prediction only ; IPR025602 [BCP1 family] -- -- E9Q020 WW domain-containing adapter protein with coiled-coil Wac 260 274.5 272.3 241 246.2 262.1 1.0767382890698 0.0695863283344244 0.106667632478954 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Spliceosomal protein FBP11/Splicing factor PRP40 A RNA processing and modification ; IPR001202 [WW domain] -- -- A0A0G2JEB6 Cilia and flagella-associated protein 47 Cfap47 716.5 681 595.9 691.8 714.7 637.8 0.975101501736536 0.709662389483762 -0.0363756930198256 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR001715 [Calponin homology domain] -- -- Q9WV52 Pleckstrin-2 Plek2 282.5 279.6 223.6 116 109.3 98 2.43025054129292 0.00148975137708912 1.28110505294567 Significant up 1 Biological Process:intracellular signal transduction (GO:0035556) pleckstrin -- -- -- -- -- IPR000591 [DEP domain] ; IPR001849[Pleckstrin homology domain] -- -- Q6ZPR8 Anaphase-promoting complex subunit 2 (Fragment) Anapc2 60.3 57.5 59.6 58.2 54.5 66.2 0.991615427613192 0.894909563170932 -0.0121473777508443 Nonsignificant None 2 Biological Process:ubiquitin-dependent protein catabolic process (GO:0006511),Molecular Function:ubiquitin protein ligase binding (GO:0031625) anaphase-promoting complex subunit 2 -- ko04110 Cell cycle ko04114 Oocyte meiosis ko04120 Ubiquitin mediated proteolysis ko04914 Progesterone-mediated oocyte maturation ko05166 HTLV-I infection Anaphase-promoting complex (APC), subunit 2 DO Cell cycle control, cell division, chromosome partitioning ; Posttranslational modification, protein turnover, chaperones ; IPR001373 [Cullin, N-terminal] ; IPR014786[Anaphase-promoting complex subunit 2, C-terminal] -- -- A0A2I3BQG2 Crystallin beta-gamma domain-containing 2 Crybg2 82.4 73.5 75 71.8 83 71.5 1.02032699955811 0.759547327644556 0.0290315885072226 Nonsignificant None -- -- -- -- -- -- -- -- IPR001064 [Beta/gamma crystallin] -- -- V9GXH2 Etoposide-induced protein 2.4 (Fragment) Ei24 179.6 175.1 219.8 221.2 223.4 189.2 0.906437361943831 0.33383311089078 -0.141720766848758 Nonsignificant None -- -- etoposide-induced 2.4 mRNA -- ko04115 p53 signaling pathway p53-mediated apoptosis protein EI24/PIG8 TV Signal transduction mechanisms ; Defense mechanisms ; -- -- -- B9EKR4 Phosphatidylinositol-3,4, 5-trisphosphate-dependent Rac exchange factor 1 Prex1 107.8 90.1 103.6 78.4 90.2 77.4 1.22560975609756 0.0516104880872588 0.293499686560845 Nonsignificant None 3 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Biological Process:regulation of Rho protein signal transduction (GO:0035023),Biological Process:intracellular signal transduction (GO:0035556) phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchanger 1 protein -- ko04062 Chemokine signaling pathway ko05167 Kaposi's sarcoma-associated herpesvirus infection -- -- -- IPR000219 [Dbl homology (DH) domain] ; IPR000591[DEP domain] -- -- O88393 Transforming growth factor beta receptor type 3 Tgfbr3 71 89 92.6 89.3 82.1 80 1.00477326968974 0.958649856269139 0.00686998936704463 Nonsignificant None -- -- transforming growth factor, beta receptor III -- -- -- -- -- IPR001507 [Zona pellucida domain] -- -- F6VKM0 Trafficking protein particle complex subunit 6A (Fragment) Trappc6a 80.6 68 70.6 84.9 72.5 75.7 0.94036894036894 0.434892910898238 -0.0887012061683397 Nonsignificant None -- -- trafficking protein particle complex subunit 6 -- -- Transport protein particle (TRAPP) complex subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR007194 [Transport protein particle (TRAPP) component] -- -- Q3TQZ8 Uncharacterized protein (Fragment) Slc7a1 107 76.8 57.1 54.7 48.2 55.9 1.51700251889169 0.136267719744203 0.601223481095513 Nonsignificant None 3 Biological Process:amino acid transmembrane transport (GO:0003333),Molecular Function:amino acid transmembrane transporter activity (GO:0015171),Cellular Component:membrane (GO:0016020) solute carrier family 7 (cationic amino acid transporter), member 1 -- ko05206 MicroRNAs in cancer Amino acid transporters E Amino acid transport and metabolism ; IPR002293 [Amino acid/polyamine transporter I] -- -- Q9CQF6 L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Aasdhppt 77.4 81.2 89 97.7 102.5 92.8 0.845051194539249 0.0266057245524295 -0.242889350095346 Nonsignificant None 2 Molecular Function:magnesium ion binding (GO:0000287),Molecular Function:holo-[acyl-carrier-protein] synthase activity (GO:0008897) 4'-phosphopantetheinyl transferase 2.7.8.- ko00770 Pantothenate and CoA biosynthesis Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase EH Amino acid transport and metabolism ; Coenzyme transport and metabolism ; IPR008278 [4'-phosphopantetheinyl transferase superfamily] -- -- Q9CQY1 Ubiquitin-like protein ATG12 Atg12 13.9 16.6 23.4 40.9 35.7 28.9 0.510900473933649 0.018453434835558 -0.968885820842042 Significant down 2 Biological Process:autophagosome assembly (GO:0000045),Cellular Component:cytoplasm (GO:0005737) ubiquitin-like protein ATG12 -- ko04068 FoxO signaling pathway ko04136 Autophagy - other ko04140 Autophagy - animal ko04621 NOD-like receptor signaling pathway ko04622 RIG-I-like receptor signaling pathway Protein conjugation factor involved in autophagy O Posttranslational modification, protein turnover, chaperones ; IPR007242 [Ubiquitin-like protein Atg12] -- -- O88888 Amyloid-beta A4 precursor protein-binding family A member 3 Apba3 5.8 3.7 0 4.3 4.6 5.6 0.982758620689655 0.934436450908903 -0.0250909809628303 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Beta amyloid precursor-binding protein R General function prediction only ; IPR001478 [PDZ domain] ; IPR006020[PTB/PI domain] -- -- P32848 Parvalbumin alpha Pvalb 38.1 38.9 51.7 116.2 112.6 54.8 0.453808180535966 0.064387562022337 -1.13984547901881 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) -- -- -- Calmodulin and related proteins (EF-Hand superfamily) T Signal transduction mechanisms ; IPR002048 [EF-hand domain] -- -- Q8BIX3 ARL14 effector protein Arl14ep 48.9 46.8 75.3 78.6 77.8 63.2 0.778688524590164 0.195921928472218 -0.360881729231939 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR029264 [ARF7 effector protein, C-terminal] -- -- Q00780 Collagen alpha-1(VIII) chain Col8a1 33.3 30.3 30.5 35.2 26.7 30.7 1.01619870410367 0.858965819428592 0.0231825294683004 Nonsignificant None -- -- -- -- -- -- -- -- IPR001073 [C1q domain] ; IPR008160[Collagen triple helix repeat] -- -- A0A0N4SUN4 Rabenosyn-5 (Fragment) Rbsn 23.4 20.1 15.7 23.2 18 23.8 0.910769230769231 0.540451135951233 -0.134842542286867 Nonsignificant None -- -- rabenosyn-5 -- ko04144 Endocytosis FYVE finger-containing protein R General function prediction only ; -- -- -- Q8K337 Type II inositol 1,4,5-trisphosphate 5-phosphatase Inpp5b 115.5 121.6 117.9 103.6 93.1 104.7 1.17783676177837 0.0120904899093462 0.236139607681583 Nonsignificant None 1 Biological Process:signal transduction (GO:0007165) inositol polyphosphate 5-phosphatase INPP5B/F 3.1.3.36 ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system Inositol polyphosphate 5-phosphatase and related proteins U Intracellular trafficking, secretion, and vesicular transport ; IPR000198 [Rho GTPase-activating protein domain] ; IPR005135[Endonuclease/exonuclease/phosphatase] ; IPR031896[Type II inositol 1,4,5-trisphosphate 5-phosphatase, PH domain] -- -- Q8QZX2 HAUS augmin-like complex subunit 3 Haus3 45.3 39 48.9 28.5 32.4 28.4 1.49160134378499 0.0100045687724358 0.576862001950039 Nonsignificant None -- -- HAUS augmin-like complex subunit 3 -- -- -- -- -- IPR032733 [HAUS augmin-like complex subunit 3, N-terminal] -- -- P21570 Angiogenin Ang 323.3 359.5 365.4 328.9 323.1 332.8 1.06437855402112 0.191456752351566 0.0900113471534583 Nonsignificant None -- -- angiogenin 3.1.27.- -- -- -- -- IPR023412 [Ribonuclease A-domain] -- -- Q925A3 Fibroblast growth factor Fgf2 35.9 29.6 23.1 29.7 23.2 34.4 1.01489117983963 0.934037917303604 0.0213250449255785 Nonsignificant None 1 Molecular Function:growth factor activity (GO:0008083) fibroblast growth factor 2 -- ko01521 EGFR tyrosine kinase inhibitor resistance ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04151 PI3K-Akt signaling pathway ko04550 Signaling pathways regulating pluripotency of stem cells ko04810 Regulation of actin cytoskeleton ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05218 Melanoma ko05224 Breast cancer ko05226 Gastric cancer Fibroblast growth factor T Signal transduction mechanisms ; IPR002209 [Fibroblast growth factor family] -- -- E0CXW2 Uncharacterized aarF domain-containing protein kinase 5 Adck5 37.9 33.5 42.3 34.2 38.3 53.4 0.903097696584591 0.557730356117305 -0.147046028826769 Nonsignificant None -- -- aarF domain-containing kinase -- -- Predicted unusual protein kinase R General function prediction only ; IPR004147 [UbiB domain] -- -- Q8K395 Thnsl1 protein (Fragment) Thnsl1 19.4 14.6 9.3 17.7 21.7 20.8 0.719269102990033 0.149058082750423 -0.475396462032977 Nonsignificant None -- -- -- -- -- Pyridoxalphosphate-dependent enzyme/predicted threonine synthase E Amino acid transport and metabolism ; -- -- -- A0A2I3BQS8 Complex1_LYR_dom domain-containing protein Gm55359 226.2 216.4 236.3 197.6 191.2 197.1 1.15873015873016 0.00707662419773818 0.212544635380101 Nonsignificant None -- -- -- -- -- -- -- -- IPR008011 [Complex 1 LYR protein] -- -- Q91WM3 U3 small nucleolar RNA-interacting protein 2 Rrp9 116 114.4 92 90.6 75.4 89.8 1.26035965598124 0.0730513339998842 0.33383547964633 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) ribosomal RNA-processing protein 9 -- -- U3 snoRNP-associated protein (contains WD40 repeats) A RNA processing and modification ; IPR001680 [WD40 repeat] -- -- A0A2U3TZ49 Voltage-dependent L-type calcium channel subunit beta-3 Cacnb3 75.9 77.2 83.3 90.8 84.3 93.4 0.880446927374302 0.03904053006175 -0.183692052695243 Nonsignificant None 3 Molecular Function:voltage-gated calcium channel activity (GO:0005245),Cellular Component:voltage-gated calcium channel complex (GO:0005891),Biological Process:calcium ion transmembrane transport (GO:0070588) voltage-dependent calcium channel beta-3 -- ko04010 MAPK signaling pathway ko04260 Cardiac muscle contraction ko04261 Adrenergic signaling in cardiomyocytes ko04921 Oxytocin signaling pathway ko05410 Hypertrophic cardiomyopathy (HCM) ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ko05414 Dilated cardiomyopathy (DCM) L-type voltage-dependent Ca2+ channel, beta subunit PT Inorganic ion transport and metabolism ; Signal transduction mechanisms ; IPR000584 [Voltage-dependent calcium channel, L-type, beta subunit] ; IPR008145[Guanylate kinase/L-type calcium channel beta subunit] -- -- H3BL50 Ceramide synthase 4 Cers4 410.3 416.4 415.2 463.6 503.1 424.2 0.892875116830829 0.160143210669474 -0.163469689896976 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Cellular Component:integral component of membrane (GO:0016021) ceramide synthetase 2.3.1.24 ko00600 Sphingolipid metabolism ko01100 Metabolic pathways ko04071 Sphingolipid signaling pathway Protein transporter of the TRAM (translocating chain-associating membrane) superfamily U Intracellular trafficking, secretion, and vesicular transport ; IPR001356 [Homeobox domain] ; IPR006634[TRAM/LAG1/CLN8 homology domain] -- Homeobox P97465 Docking protein 1 Dok1 154.4 157.1 183 167.9 154.6 154.2 1.03734004615062 0.590837696392951 0.0528888955767979 Nonsignificant None 1 Molecular Function:insulin receptor binding (GO:0005158) docking protein 1 -- ko05162 Measles Docking protein 1 (p62dok) T Signal transduction mechanisms ; IPR001849 [Pleckstrin homology domain] ; IPR002404[IRS-type PTB domain] -- -- Q9D0T2 Dual specificity protein phosphatase 12 Dusp12 358.3 426.7 254.7 184.8 163.2 222.2 1.82339529989477 0.0415841512328082 0.866627361911923 Significant up 2 Biological Process:protein dephosphorylation (GO:0006470),Molecular Function:protein tyrosine/serine/threonine phosphatase activity (GO:0008138) -- -- -- Dual specificity phosphatase V Defense mechanisms ; IPR000340 [Dual specificity phosphatase, catalytic domain] -- -- A4PI83 Ca2+-dependent activator protein for secretion 2 isoform d Cadps2 7.8 17.3 36.3 24.8 26.3 22.8 0.83085250338295 0.669166856345315 -0.267335708775972 Nonsignificant None -- -- calcium-dependent secretion activator -- -- Ca2+-dependent activator protein T Signal transduction mechanisms ; IPR001849 [Pleckstrin homology domain] -- -- H3BIV5 A-kinase anchor protein 5 Akap5 18.7 22.4 19 15.9 19.3 19 1.10885608856089 0.288695956328846 0.149072139357314 Nonsignificant None 2 Biological Process:protein targeting (GO:0006605),Biological Process:signal transduction (GO:0007165) A-kinase anchor protein 5 -- -- -- -- -- IPR001573 [Protein kinase A anchoring, WSK motif] -- -- Q8BGT1 Leucine-rich repeat transmembrane protein FLRT3 Flrt3 185.1 198.8 172.5 280.9 282.1 208.4 0.721285973554576 0.0484302863925376 -0.471356726086523 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) leucine-rich repeat transmembrane protein FLRT -- -- -- -- -- IPR001611 [Leucine-rich repeat] -- -- Q149F1 Pseudouridylate synthase RPUSD2 Rpusd2 397.3 354 311.6 284.7 335.8 333.4 1.11426774294999 0.290005868952245 0.156095933768307 Nonsignificant None 4 Biological Process:pseudouridine synthesis (GO:0001522),Molecular Function:RNA binding (GO:0003723),Biological Process:RNA modification (GO:0009451),Molecular Function:pseudouridine synthase activity (GO:0009982) -- -- -- RNA pseudouridylate synthases A RNA processing and modification ; IPR006145 [Pseudouridine synthase, RsuA/RluB/C/D/E/F] -- -- B1AV66 Protein YIPF (Fragment) Yipf6 13.3 29.1 34.3 52.1 46.7 39.8 0.553391053391053 0.0465576636416241 -0.853628774634281 Significant down 1 Cellular Component:membrane (GO:0016020) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR006977 [Yip1 domain] -- -- Q6ZPN6 Oxysterol-binding protein (Fragment) mKIAA1534 20.6 15.9 24.2 26 23.2 23.8 0.831506849315069 0.183053170838922 -0.266199947511697 Nonsignificant None -- -- oxysterol-binding protein-related protein 5 -- ko04979 Cholesterol metabolism Oxysterol-binding protein T Signal transduction mechanisms ; IPR000648 [Oxysterol-binding protein] -- -- Q3TDV6 Uncharacterized protein Mad1l1 704.5 755.7 570.1 816.8 880.3 689.5 0.850708120338557 0.206247558208018 -0.233263869639843 Nonsignificant None 1 Biological Process:mitotic spindle assembly checkpoint (GO:0007094) mitotic spindle assembly checkpoint protein MAD1 -- ko04110 Cell cycle ko04914 Progesterone-mediated oocyte maturation ko05203 Viral carcinogenesis Mitotic checkpoint protein MAD1 D Cell cycle control, cell division, chromosome partitioning ; IPR008672 [Spindle assembly checkpoint component Mad1] -- -- Q8K3W3 Protein CASC3 Casc3 133.1 404.7 185.7 263.8 279.7 146.6 1.0483987827851 0.910629389188418 0.0681875837780961 Nonsignificant None -- -- protein CASC3 -- ko03013 RNA transport ko03015 mRNA surveillance pathway Nucleo-cytoplasmic protein MLN51 R General function prediction only ; IPR018545 [Btz domain] -- -- Q3TKB7 28S ribosomal protein S18b, mitochondrial Mrps18b 224.1 223.7 247 243.8 242.5 241.8 0.954264524103832 0.285869456046223 -0.0675388551618973 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S18b, mitochondrial -- ko05203 Viral carcinogenesis Mitochondrial ribosomal protein S18b J Translation, ribosomal structure and biogenesis ; IPR001648 [Ribosomal protein S18] -- -- Q91VU8 Prostate tumor-overexpressed gene 1 protein homolog Ptov1 23.1 19.7 8.5 17.9 12.9 20.8 0.994186046511628 0.984933814536653 -0.00841223981619994 Nonsignificant None -- -- -- -- -- -- -- -- IPR021394 [Mediator complex, subunit Med25, PTOV activation and synapsin 2] -- -- Q8BH02 Torsin-4A Tor4a 48.9 36.1 49.2 39.7 48.6 38.1 1.06170886075949 0.656128127320214 0.0863882080230808 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) -- -- -- ATPase of the AAA+ superfamily R General function prediction only ; IPR010448 [Torsin] -- -- P55288 Cadherin-11 Cdh11 430.1 420.1 443.5 379.6 399.8 399.4 1.09747200542925 0.0157591804628477 0.134184139629885 Nonsignificant None 3 Molecular Function:calcium ion binding (GO:0005509),Biological Process:homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156),Cellular Component:membrane (GO:0016020) cadherin 11, type 2, OB-cadherin -- -- FOG: Cadherin repeats S Function unknown ; IPR000233 [Cadherin, cytoplasmic domain] ; IPR002126[Cadherin] -- -- Q8K320 Thromboxane A synthase 1, platelet Tbxas1 62.1 48 43.4 50.7 55 56.8 0.944615384615385 0.63840603729008 -0.0822010625456374 Nonsignificant None 3 Molecular Function:iron ion binding (GO:0005506),Molecular Function:heme binding (GO:0020037),Biological Process:oxidation-reduction process (GO:0055114) thromboxane-A synthase 5.3.99.5 ko00590 Arachidonic acid metabolism ko01100 Metabolic pathways ko04611 Platelet activation Cytochrome P450 CYP3/CYP5/CYP6/CYP9 subfamilies Q Secondary metabolites biosynthesis, transport and catabolism ; IPR001128 [Cytochrome P450] -- -- Q812A5 Proline-rich protein 5 Prr5 23.3 22.9 21.4 18.9 26.9 21.7 1.00148148148148 0.98964449536683 0.00213574434399099 Nonsignificant None -- -- proline-rich protein 5 -- ko04150 mTOR signaling pathway -- -- -- IPR013745 [TORC2 component Bit61/PRR5] -- -- P97313 DNA-dependent protein kinase catalytic subunit Prkdc 38.1 32.5 35.7 43.8 38.3 42.9 0.8504 0.0569728350449127 -0.233786498018344 Nonsignificant None 7 Molecular Function:DNA binding (GO:0003677),Molecular Function:DNA-dependent protein kinase activity (GO:0004677),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Cellular Component:nucleus (GO:0005634),Biological Process:double-strand break repair via nonhomologous end joining (GO:0006303),Molecular Function:kinase activity (GO:0016301) DNA-dependent protein kinase catalytic subunit 2.7.11.1 ko03450 Non-homologous end-joining ko04110 Cell cycle DNA-dependent protein kinase L Replication, recombination and repair ; IPR000403 [Phosphatidylinositol 3-/4-kinase, catalytic domain] ; IPR003151[PIK-related kinase, FAT] ; IPR003152[FATC domain] ; IPR012582[NUC194] -- -- Q8BI29 Specifically androgen-regulated gene protein Sarg 73.7 62.9 69 66.4 56.1 59.1 1.13215859030837 0.141369882752576 0.179076061902963 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q8R0L1 Signal-transducing adaptor protein 2 Stap2 56.2 53.2 55.8 59.8 54.3 65.9 0.917777777777778 0.229231553221884 -0.123783219797592 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q6P3Z3 Peroxynitrite isomerase THAP4 Thap4 186.1 143.4 136.6 184.2 184.4 162.2 0.87810851544838 0.277068187610226 -0.187528857831249 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR006612 [Zinc finger, C2CH-type] ; IPR014878[Domain of unknown function DUF1794] -- THAP Q8BTV1 Tumor suppressor candidate 3 Tusc3 216.8 238.8 242.1 186.8 179.4 189.9 1.2546304621471 0.00521218375850891 0.327262496499551 Nonsignificant None -- -- oligosaccharyltransferase complex subunit gamma -- ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways ko04141 Protein processing in endoplasmic reticulum Oligosaccharyltransferase, gamma subunit O Posttranslational modification, protein turnover, chaperones ; IPR021149 [Oligosaccharyl transferase complex, subunit OST3/OST6] -- -- Q9CZN8 Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial Qrsl1 60.8 54 73.9 67.8 65.1 77.6 0.896437054631829 0.355764789375872 -0.157725810353313 Nonsignificant None -- -- -- -- ko00970 Aminoacyl-tRNA biosynthesis ko01100 Metabolic pathways Amidases J Translation, ribosomal structure and biogenesis ; IPR023631 [Amidase signature domain] -- -- Q9DBW3 Protein NATD1 Natd1 74.9 65.9 72.3 83.9 88.9 82.5 0.834704269486878 0.0130963042986342 -0.260662944624416 Nonsignificant None -- -- uncharacterized protein -- -- -- -- -- IPR031165 [Yjdj-type Gcn5-related N-acetyltransferase] -- -- Q3TYE5 Limbic system-associated membrane protein Lsamp 132.1 135.5 205 193.8 196.3 174.8 0.836608249247654 0.280962492329602 -0.257375871361538 Nonsignificant None -- -- limbic system-associated membrane protein -- -- FOG: Immunoglobulin C-2 Type/fibronectin type III domains T Signal transduction mechanisms ; IPR013098 [Immunoglobulin I-set] -- -- Q5FWI3 Cell surface hyaluronidase Cemip2 97.6 93.6 87.4 80.8 96.4 85.1 1.06214258482653 0.380519536003145 0.0869774503362687 Nonsignificant None -- -- cell surface hyaluronidase 3.2.1.35 -- -- -- -- IPR019316 [G8 domain] -- -- Q8CB55 AAA domain-containing protein Nav1 36 30.8 20.6 30.9 32.4 39.2 0.852682926829268 0.387397515101957 -0.22991872489221 Nonsignificant None -- -- neuron navigator 1 -- -- -- -- -- -- -- -- H3BL08 Ceramide synthase 6 Cers6 279.4 314 551.7 463.6 441.2 416.7 0.866515323496027 0.56445908355837 -0.206702832592218 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Cellular Component:integral component of membrane (GO:0016021) ceramide synthetase 2.3.1.24 ko00600 Sphingolipid metabolism ko01100 Metabolic pathways ko04071 Sphingolipid signaling pathway Protein transporter of the TRAM (translocating chain-associating membrane) superfamily U Intracellular trafficking, secretion, and vesicular transport ; IPR001356 [Homeobox domain] ; IPR006634[TRAM/LAG1/CLN8 homology domain] -- Homeobox Q9Z0Z7 Krueppel-like factor 5 Klf5 155 128.3 114.8 126 140 134.7 0.993511355128525 0.94803781182574 -0.00939163833944844 Nonsignificant None -- -- krueppel-like factor 5 -- -- FOG: Zn-finger R General function prediction only ; -- -- zf-C2H2 Q8BJM7 S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 Tyw1 21.3 24.1 25.3 23.2 20.2 23.6 1.05522388059701 0.483455396675168 0.077549119464264 Nonsignificant None 3 Molecular Function:catalytic activity (GO:0003824),Molecular Function:FMN binding (GO:0010181),Molecular Function:iron-sulfur cluster binding (GO:0051536) tRNA wybutosine-synthesizing protein 1 4.1.3.44 -- Fe-S oxidoreductase C Energy production and conversion ; IPR007197 [Radical SAM] ; IPR008254[Flavodoxin/nitric oxide synthase] ; IPR013917[tRNA wybutosine-synthesis] -- -- Q8CHY3 Dymeclin Dym 233.4 215.9 237.1 373.3 373.9 364.7 0.61732170159187 0.0000387722054633662 -0.695905585514727 Significant down -- -- -- -- -- Proteins containing regions of low-complexity R General function prediction only ; -- -- -- Q9CQP0 39S ribosomal protein L33, mitochondrial Mrpl33 247.3 236.4 259.4 226.7 228.7 225.9 1.09070893879348 0.087912037205632 0.125266162539475 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L33 -- ko03010 Ribosome Mitochondrial/chloroplast ribosomal protein L33-like J Translation, ribosomal structure and biogenesis ; IPR001705 [Ribosomal protein L33] -- -- Q8BUP0 START domain-containing protein (Fragment) Stard7 10.5 10.9 6.6 7.7 7.2 13.1 1 1 0 Nonsignificant None 1 Molecular Function:lipid binding (GO:0008289) -- -- -- START domain-containing proteins involved in steroidogenesis/phosphatidylcholine transfer I Lipid transport and metabolism ; IPR002913 [START domain] -- -- H3BIW9 Kinase (Fragment) Ip6k1 35.3 38.6 39 55.6 49.5 53.9 0.710062893081761 0.00207313487156635 -0.493981279398717 Nonsignificant None 1 Molecular Function:inositol-1,4,5-trisphosphate 3-kinase activity (GO:0008440) inositol-hexakisphosphate 5-kinase 2.7.4.21 ko04070 Phosphatidylinositol signaling system Inositol polyphosphate multikinase, component of the ARGR transcription regulatory complex KIT Transcription ; Lipid transport and metabolism ; Signal transduction mechanisms ; IPR005522 [Inositol polyphosphate kinase] -- -- D3Z197 Histone-lysine N-methyltransferase NSD3 Nsd3 99.1 94.7 79.1 85.3 108.9 101.6 0.922582826233942 0.455416069000111 -0.116249657824927 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) histone-lysine N-methyltransferase NSD3 2.1.1.43 ko00310 Lysine degradation Transcription factor NSD1 and related SET domain proteins K Transcription ; IPR000313 [PWWP domain] ; IPR001214[SET domain] -- -- A0A2R3XZC4 Stimulator of interferon genes protein Sting1 710.5 833.4 397.6 230 250.4 290.5 2.51848488779349 0.0923989839221825 1.33255607410874 Nonsignificant None 2 Biological Process:activation of innate immune response (GO:0002218),Biological Process:positive regulation of type I interferon production (GO:0032481) transmembrane protein 173 -- ko04621 NOD-like receptor signaling pathway ko04622 RIG-I-like receptor signaling pathway ko04623 Cytosolic DNA-sensing pathway -- -- -- IPR029158 [Stimulator of interferon genes protein] -- -- Q8BGR8 GSK3B-interacting protein Gskip 101.2 101.6 100 116.8 138.2 105.7 0.839478791239257 0.180032999096208 -0.252434217801839 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR007967 [Protein of unknown function DUF727] -- -- Q9DCT5 Stromal cell-derived factor 2 Sdf2 346.4 240.1 114.3 124.1 145.2 150.4 1.66976411722659 0.296610799247761 0.739644311715264 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) -- -- -- Uncharacterized secreted protein SDF2 (Stromal cell-derived factor 2), contains MIR domains R General function prediction only ; IPR016093 [MIR motif] -- -- A0A1D5RLN6 RIKEN cDNA 2900026A02 gene 2900026A02Rik 54.6 38.9 48.1 46.2 40.7 51.5 1.02312138728324 0.856175110588168 0.0329773224462728 Nonsignificant None -- -- -- -- -- -- -- -- IPR032764 [Tankyrase 1-binding protein, C-terminal] -- -- Q9D4V0 Ethanolamine kinase 1 Etnk1 71.2 65.6 72.8 61.3 74 60.5 1.07048008171604 0.399884785942494 0.0982579519337552 Nonsignificant None -- -- ethanolamine kinase 2.7.1.82 ko00564 Glycerophospholipid metabolism ko01100 Metabolic pathways Ethanolamine kinase I Lipid transport and metabolism ; -- -- -- A0A0G2JDK3 Geranylgeranyl transferase type-2 subunit beta (Fragment) Rabggtb 115.8 130.7 122.5 118.2 127.7 141.3 0.952995867768595 0.488874342644872 -0.0694581363268361 Nonsignificant None 1 Molecular Function:catalytic activity (GO:0003824) geranylgeranyl transferase type-2 subunit beta 2.5.1.60 -- Protein geranylgeranyltransferase type II, beta subunit O Posttranslational modification, protein turnover, chaperones ; IPR001330 [PFTB repeat] -- -- Q91XX1 Protocadherin gamma C3 Pcdhgc3 15.8 16.3 18.4 12.2 14.2 15.6 1.20238095238095 0.0891621654783431 0.265894059973034 Nonsignificant None 3 Molecular Function:calcium ion binding (GO:0005509),Biological Process:homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156),Cellular Component:membrane (GO:0016020) protocadherin gamma subfamily C -- -- FOG: Cadherin repeats S Function unknown ; IPR002126 [Cadherin] ; IPR013164[Cadherin, N-terminal] ; IPR031904[Cadherin, C-terminal catenin-binding domain] ; IPR032455[Cadherin, cytoplasmic C-terminal domain] -- -- Q9EQ32 Phosphoinositide 3-kinase adapter protein 1 Pik3ap1 22.2 23.6 28.8 32.6 29.1 28.9 0.823399558498896 0.0848386951946995 -0.280335419790997 Nonsignificant None -- -- phosphoinositide 3-kinase adapter protein 1 -- ko04151 PI3K-Akt signaling pathway ko04662 B cell receptor signaling pathway -- -- -- IPR017893 [DBB domain] -- -- V9GXF1 RIKEN cDNA 1110065P20 gene 1110065P20Rik 34.2 38.1 53.9 48.4 42.7 37 0.985167837626854 0.930913490489112 -0.0215585653590976 Nonsignificant None -- -- -- -- -- -- -- -- IPR031714 [Protein of unknown function DUF4726] -- -- A0A0J9YUC8 Arachidonate 5-lipoxygenase-activating protein Alox5ap 60.9 82.2 36.8 28.1 25 26.9 2.24875 0.125689210676663 1.16912328147676 Nonsignificant None -- -- arachidonate 5-lipoxygenase-activating protein -- ko04664 Fc epsilon RI signaling pathway -- -- -- -- -- -- Q0VGT3 Pogo transposable element with ZNF domain Pogz 140 136.1 138.2 119.7 134.3 135.5 1.06367137355584 0.187233265258522 0.0890524920301754 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- FOG: Zn-finger R General function prediction only ; IPR004875 [DDE superfamily endonuclease domain] ; IPR006600[HTH CenpB-type DNA-binding domain] -- -- A2A7G9 F-box only protein 6 (Fragment) Fbxo6 74.8 79 75.8 58 66.8 94 1.04936014625229 0.772019670227559 0.069509903883131 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) F-box protein 6 -- ko04141 Protein processing in endoplasmic reticulum -- -- -- IPR001810 [F-box domain] ; IPR007397[F-box associated (FBA) domain] -- -- O08856 RNA polymerase II elongation factor ELL Ell 9.7 17.9 12.1 9.8 17.5 15.1 0.936320754716981 0.800411199757379 -0.0949252574202415 Nonsignificant None 2 Biological Process:transcription elongation from RNA polymerase II promoter (GO:0006368),Cellular Component:transcription elongation factor complex (GO:0008023) RNA polymerase II elongation factor ELL -- -- RNA polymerase II elongation factor K Transcription ; IPR010844 [Occludin homology domain] ; IPR019464[RNA polymerase II elongation factor ELL, N-terminal] -- -- S4R2B6 Anaphase-promoting complex subunit 16 Anapc16 39.5 35.6 28.8 33.4 34.4 36.6 0.995210727969349 0.961749463169984 -0.00692605766567261 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q9DCB1 High mobility group nucleosome-binding domain-containing protein 3 Hmgn3 259.7 262.8 225.8 222.1 241.8 238.8 1.06489255727907 0.318164899568148 0.0907078765542541 Nonsignificant None 3 Cellular Component:chromatin (GO:0000785),Cellular Component:nucleus (GO:0005634),Molecular Function:nucleosomal DNA binding (GO:0031492) high-mobility group nucleosome-binding domain-containing protein 3 -- -- -- -- -- IPR000079 [High mobility group protein HMGN] -- -- Q8R5M8 Cell adhesion molecule 1 Cadm1 170.8 91.2 74.7 81 89.4 90.7 1.28954423592493 0.485510086003305 0.366861263514804 Nonsignificant None -- -- cell adhesion molecule 1 -- ko04514 Cell adhesion molecules (CAMs) -- -- -- IPR013106 [Immunoglobulin V-set domain] ; IPR013162[CD80-like, immunoglobulin C2-set] -- -- Q3U1N6 Uncharacterized protein (Fragment) Txndc11 22.9 14.7 15.4 17.1 13.6 12.7 1.22119815668203 0.338706117972697 0.288297317006082 Nonsignificant None 1 Biological Process:cell redox homeostasis (GO:0045454) -- -- -- Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) O Posttranslational modification, protein turnover, chaperones ; IPR013766 [Thioredoxin domain] -- -- D3Z2C5 Dimethylaniline monooxygenase [N-oxide-forming] 4 (Fragment) Fmo4 93.9 89.6 82.2 108.5 103.2 110.3 0.825155279503106 0.00958685084048832 -0.277262460511473 Nonsignificant None 4 Molecular Function:N,N-dimethylaniline monooxygenase activity (GO:0004499),Molecular Function:flavin adenine dinucleotide binding (GO:0050660),Molecular Function:NADP binding (GO:0050661),Biological Process:oxidation-reduction process (GO:0055114) dimethylaniline monooxygenase (N-oxide forming) 1.14.13.8 ko00982 Drug metabolism - cytochrome P450 Flavin-containing monooxygenase Q Secondary metabolites biosynthesis, transport and catabolism ; IPR020946 [Flavin monooxygenase-like] -- -- Q9D924 Iron-sulfur cluster assembly 1 homolog, mitochondrial Isca1 192.4 201.3 187.9 208.8 192.1 201.6 0.965311203319502 0.326499574515537 -0.050933972085092 Nonsignificant None -- -- iron-sulfur cluster assembly 1 -- -- Fe-S cluster biosynthesis protein ISA1 (contains a HesB-like domain) P Inorganic ion transport and metabolism ; IPR000361 [FeS cluster biogenesis] -- -- A0A0R4J0B6 Broad substrate specificity ATP-binding cassette transporter ABCG2 Abcg2 191.2 191 234.1 213.1 212.5 208.5 0.971928717867844 0.719680451213926 -0.0410775857369676 Nonsignificant None 3 Molecular Function:ATP binding (GO:0005524),Cellular Component:membrane (GO:0016020),Molecular Function:ATPase activity (GO:0016887) ATP-binding cassette, subfamily G (WHITE), member 2 -- ko01523 Antifolate resistance ko02010 ABC transporters ko04976 Bile secretion Transporter, ABC superfamily (Breast cancer resistance protein) Q Secondary metabolites biosynthesis, transport and catabolism ; IPR003439 [ABC transporter-like] ; IPR013525[ABC-2 type transporter] -- -- P51576 P2X purinoceptor 1 P2rx1 77.7 64.3 53.9 44.8 51.9 58.3 1.26387096774194 0.160105612889265 0.337849182105987 Nonsignificant None 5 Molecular Function:purinergic nucleotide receptor activity (GO:0001614),Molecular Function:extracellular ATP-gated cation channel activity (GO:0004931),Cellular Component:integral component of plasma membrane (GO:0005887),Biological Process:response to ATP (GO:0033198),Biological Process:cation transmembrane transport (GO:0098655) P2X purinoceptor 1 -- ko04020 Calcium signaling pathway ko04080 Neuroactive ligand-receptor interaction ko04611 Platelet activation -- -- -- IPR001429 [P2X purinoreceptor] -- -- E9PXB0 Calcium-independent phospholipase A2-gamma Pnpla8 42.3 42.5 44 44 50.8 46.1 0.914123491838183 0.12458547376522 -0.12953901819502 Nonsignificant None 1 Biological Process:lipid metabolic process (GO:0006629) calcium-independent phospholipase A2-gamma -- -- Intracellular membrane-bound Ca2+-independent phospholipase A2 I Lipid transport and metabolism ; IPR002641 [Patatin/Phospholipase A2-related] -- -- E9Q7E2 AT-rich interactive domain-containing protein 2 Arid2 315.1 308.6 315.4 292.5 317.6 291.2 1.04193942083657 0.228633002444755 0.0592714006497368 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) AT-rich interactive domain-containing protein 2 -- ko05225 Hepatocellular carcinoma Predicted transcriptional regulator, contains ARID domain K Transcription ; IPR001606 [ARID DNA-binding domain] ; IPR003150[DNA-binding RFX-type winged-helix domain] -- ARID Q8R2N2 U3 small nucleolar RNA-associated protein 4 homolog Utp4 95.7 136.3 176.1 166.9 158.1 177.7 0.811816192560175 0.257357224352436 -0.300774978437267 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) U3 small nucleolar RNA-associated protein 4 -- ko03008 Ribosome biogenesis in eukaryotes WD40 repeat protein R General function prediction only ; IPR001680 [WD40 repeat] -- -- P70700 DNA-directed RNA polymerase I subunit RPA2 Polr1b 96.9 100.2 84.6 102.2 112.2 107.4 0.87538844002486 0.0738853982676088 -0.192004762348515 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Molecular Function:DNA-directed 5'-3' RNA polymerase activity (GO:0003899),Cellular Component:nucleus (GO:0005634) DNA-directed RNA polymerase I subunit RPA2 2.7.7.6 ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways ko03020 RNA polymerase RNA polymerase I, second largest subunit K Transcription ; IPR007120 [DNA-directed RNA polymerase, subunit 2, domain 6] ; IPR007641[RNA polymerase Rpb2, domain 7] ; IPR007642[RNA polymerase Rpb2, domain 2] ; IPR007644[RNA polymerase, beta subunit, protrusion] ; IPR007645[RNA polymerase Rpb2, domain 3] ; IPR009674[DNA-directed RNA polymerase I subunit RPA2, domain 4] -- -- Q8K1F0 Anti-VIPase light chain variable region (Fragment) 400.8 430.1 446.5 356.2 355.3 327.7 1.22921478060046 0.00823796951166432 0.297737019725569 Nonsignificant None -- -- pre-B lymphocyte gene -- -- -- -- -- IPR013106 [Immunoglobulin V-set domain] -- -- Q8R3W2 RIKEN cDNA 0610009B22 gene 0610009B22Rik 193.9 164.4 166 160 149.4 170.6 1.09229166666667 0.263704279872801 0.127358140020474 Nonsignificant None 2 Cellular Component:intracellular (GO:0005622),Biological Process:ER to Golgi vesicle-mediated transport (GO:0006888) trafficking protein particle complex subunit 2 -- -- TRAPP 20 K subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR006722 [Trafficking protein particle complex subunit 2] -- -- D3Z6T3 Cathepsin E Ctse 267 213.2 208.3 519.8 454.3 576 0.444164892587575 0.00197000052632211 -1.17083273012369 Significant down 2 Molecular Function:aspartic-type endopeptidase activity (GO:0004190),Biological Process:proteolysis (GO:0006508) cathepsin E 3.4.23.34 ko04142 Lysosome Aspartyl protease O Posttranslational modification, protein turnover, chaperones ; IPR012848 [Aspartic peptidase, N-terminal] ; IPR033121[Peptidase family A1 domain] -- -- Q7TNT6 Gas1 protein (Fragment) Gas1 80.5 78.9 93.1 88.5 94.2 101.4 0.888771559310102 0.145568221099349 -0.170115443663022 Nonsignificant None -- -- growth arrest-specific 1 -- ko04340 Hedgehog signaling pathway -- -- -- IPR016017 [GDNF/GAS1] -- -- O88597 Beclin-1 Becn1 45.3 40 36 46.6 35.5 33.3 1.05112651646447 0.709720632788583 0.0719363264750275 Nonsignificant None 1 Biological Process:autophagy (GO:0006914) beclin -- ko04136 Autophagy - other ko04137 Mitophagy - animal ko04140 Autophagy - animal ko04215 Apoptosis - multiple species ko04371 Apelin signaling pathway ko05167 Kaposi's sarcoma-associated herpesvirus infection Beclin-like protein T Signal transduction mechanisms ; IPR007243 [Atg6/Beclin] ; IPR029318[Beclin-1, BH3 domain] -- -- A2AP82 Transcription initiation factor TFIID subunit 9B Taf9b 12.7 11.8 12.4 9.2 10.7 11.1 1.19032258064516 0.0364877624054513 0.251352600786159 Nonsignificant None -- -- transcription initiation factor TFIID subunit 9B -- ko03022 Basal transcription factors ko05168 Herpes simplex infection Transcription initiation factor TFIID, subunit TAF9 (also component of histone acetyltransferase SAGA) K Transcription ; IPR003162 [Transcription initiation factor TAFII31] -- -- Q91XC9 Peroxisomal membrane protein PEX16 Pex16 298.6 245.9 239.6 188.1 215.1 214.2 1.27000323939099 0.0549398985188635 0.344832176877255 Nonsignificant None -- -- peroxin-16 -- ko04146 Peroxisome Peroxisomal biogenesis protein (peroxin 16) U Intracellular trafficking, secretion, and vesicular transport ; IPR013919 [Peroxisome membrane protein, Pex16] -- -- A2A8S2 Protein YIPF (Fragment) Yipf1 238.8 240.9 280 331.5 318.7 337.8 0.768927125506073 0.00634783293111558 -0.379081220566211 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR006977 [Yip1 domain] -- -- Q8CH02 SURP and G-patch domain-containing protein 1 Sugp1 71.7 67.8 62.1 64.1 70.1 67.4 1 1 0 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:RNA binding (GO:0003723),Biological Process:RNA processing (GO:0006396) splicing factor 4 -- -- Predicted RNA-binding protein, contains SWAP and G-patch domains R General function prediction only ; IPR000061 [SWAP/Surp] ; IPR000467[G-patch domain] -- -- Q3UDW8 Heparan-alpha-glucosaminide N-acetyltransferase Hgsnat 54.2 49.4 45.6 35.4 46.7 47.5 1.15123456790123 0.231209816006292 0.203181817370613 Nonsignificant None -- -- heparan-alpha-glucosaminide N-acetyltransferase 2.3.1.78 ko00531 Glycosaminoglycan degradation ko01100 Metabolic pathways ko04142 Lysosome Uncharacterized conserved protein S Function unknown ; IPR012429 [Domain of unknown function DUF1624] -- -- Q61362 Chitinase-3-like protein 1 Chi3l1 48.4 67.2 40.4 15.1 18.6 21 2.85191956124314 0.0141966641886251 1.51193329095705 Significant up 1 Biological Process:carbohydrate metabolic process (GO:0005975) chitinase-3-like protein 1/2 -- -- Chitinase G Carbohydrate transport and metabolism ; IPR001223 [Glycoside hydrolase family 18, catalytic domain] -- -- A0A0N4SW64 Inhibitor of growth protein 3 (Fragment) Ing3 22.3 22 17.6 19.9 22.1 18.4 1.02483443708609 0.801438864061908 0.0353908598891857 Nonsignificant None -- -- inhibitor of growth protein 3 -- -- Chromatin remodeling protein, contains PHD Zn-finger B Chromatin structure and dynamics ; IPR024610 [Inhibitor of growth protein, N-terminal histone-binding] -- -- Q7TMI3 E3 ubiquitin-protein ligase UHRF2 Uhrf2 144.6 127.1 104.4 112.5 94.2 114.8 1.16982892690513 0.244118639233388 0.226297568824997 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:histone binding (GO:0042393) E3 ubiquitin-protein ligase UHRF2 2.3.2.27 -- -- -- -- IPR000626 [Ubiquitin domain] ; IPR003105[SRA-YDG] ; IPR019787[Zinc finger, PHD-finger] ; IPR021991[UHRF1, tandem tudor domain] -- -- Q8K114 Integrator complex subunit 9 Ints9 58.9 55.4 52.2 44.2 43.8 44.7 1.25470987189148 0.0264672304350965 0.327353806588431 Nonsignificant None -- -- integrator complex subunit 9 -- -- Predicted cleavage and polyadenylation specificity factor (CPSF subunit) A RNA processing and modification ; IPR001279 [Metallo-beta-lactamase] ; IPR022712[Beta-Casp domain] -- -- Q8BIG4 F-box only protein 28 Fbxo28 107.2 90.2 106.3 107.1 124.2 123.2 0.856699576868829 0.0964012092913317 -0.223138718959419 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) F-box protein 28 -- -- -- -- -- IPR001810 [F-box domain] -- -- Q8BTU1 Cilia- and flagella-associated protein 20 Cfap20 317.2 282.3 250.3 208.2 223.9 235.3 1.27329937069224 0.0434419314197242 0.348571657130967 Nonsignificant None -- -- -- -- -- Transcription factor IIB K Transcription ; IPR007714 [Cilia/flagella-associated protein 20/WDR90/C3orf67] -- -- P62073 Mitochondrial import inner membrane translocase subunit Tim10 Timm10 165.3 180.7 136.6 196.6 205 189.6 0.816305818673884 0.0570633237821779 -0.2928183539304 Nonsignificant None -- -- mitochondrial import inner membrane translocase subunit TIM10 -- -- Mitochondrial import inner membrane translocase, subunits TIM10/TIM12 U Intracellular trafficking, secretion, and vesicular transport ; IPR004217 [Tim10/DDP family zinc finger] -- -- Q99L85 Elongator complex protein 5 Elp5 44.7 47.7 29.9 41.9 46.4 41 0.945862335653519 0.705655246674437 -0.0802978712828678 Nonsignificant None 1 Cellular Component:Elongator holoenzyme complex (GO:0033588) -- -- -- -- -- -- IPR019519 [Elongator complex protein 5] -- -- A0A1Y7VMD8 WD repeat-containing protein 41 Wdr41 38.4 38.2 30.2 50.1 54.1 53.3 0.678095238095238 0.00467783407089081 -0.560440181587087 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR001680 [WD40 repeat] -- -- F6QWW7 WAS/WASL-interacting protein family member 1 (Fragment) Wipf1 651.2 668.8 545.1 475.4 448.2 477.2 1.33145345516848 0.0176500993131762 0.413001995825044 Nonsignificant None 1 Molecular Function:actin binding (GO:0003779) WAS/WASL-interacting protein -- ko04144 Endocytosis WASP-interacting protein VRP1/WIP, contains WH2 domain Z Cytoskeleton ; IPR003124 [WH2 domain] -- -- Q3UN10 Wolframin Wfs1 60.1 57.1 72.3 80.4 68.1 59.8 0.909745559289486 0.454689271882821 -0.136464990982193 Nonsignificant None -- -- wolfamin -- ko04141 Protein processing in endoplasmic reticulum -- -- -- -- -- -- P97346 Nucleoredoxin Nxn 99.7 92.2 66.2 57.8 53.2 51.7 1.58635525507068 0.0368260596343861 0.665715890421442 Significant up -- -- nucleoredoxin 1.8.1.8 -- Thioredoxin, nucleoredoxin and related proteins R General function prediction only ; IPR012336 [Thioredoxin-like fold] -- -- E9Q565 Myocardial zonula adherens protein Myzap 133 106.8 133 142.3 130.3 144 0.894863178108497 0.208235541107075 -0.160260979386367 Nonsignificant None -- -- myocardial zonula adherens protein -- -- -- -- -- -- -- -- Q05BF9 Ppm2c protein Pdp1 22.1 13.4 12.4 16.1 12 15.8 1.09111617312073 0.711028121086559 0.125804716200822 Nonsignificant None 1 Molecular Function:catalytic activity (GO:0003824) pyruvate dehydrogenase phosphatase 3.1.3.43 -- Protein phosphatase 2C/pyruvate dehydrogenase (lipoamide) phosphatase T Signal transduction mechanisms ; IPR001932 [PPM-type phosphatase domain] -- -- Q5NCB7 RING-type E3 ubiquitin transferase Trim7 238.9 261.1 237.1 301.4 304.7 301.5 0.812141912736889 0.0164404296773772 -0.300196250589016 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Cellular Component:intracellular (GO:0005622),Molecular Function:zinc ion binding (GO:0008270) tripartite motif-containing protein 7 -- -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR000315 [B-box-type zinc finger] ; IPR003877[SPRY domain] ; IPR006574[SPRY-associated] -- -- Q8VE18 Nonsense-mediated mRNA decay factor SMG8 Smg8 158.9 156 99.2 100.5 117.8 119.7 1.22514792899408 0.281030012218383 0.292955956200332 Nonsignificant None -- -- protein SMG8 -- -- Uncharacterized conserved protein S Function unknown ; IPR019354 [Smg8/Smg9] -- -- A0A087WNX7 Snf2-related CREBBP activator protein Srcap 55.4 52.5 51.7 59.2 65.1 54.8 0.891122278056952 0.111125054696655 -0.166304685763615 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) helicase SRCAP 3.6.4.- -- SNF2 family DNA-dependent ATPase R General function prediction only ; IPR000330 [SNF2-related, N-terminal domain] ; IPR001650[Helicase, C-terminal] ; IPR014012[Helicase/SANT-associated domain] -- -- Q9JI19 Acidic fibroblast growth factor intracellular-binding protein Fibp 147.9 132.9 296.2 312 292.4 304.9 0.63455405256791 0.165973485263408 -0.65618503397264 Nonsignificant None 1 Molecular Function:fibroblast growth factor binding (GO:0017134) -- -- -- -- -- -- IPR008614 [Acidic fibroblast growth factor intracellular-binding protein] -- -- Q8VD00 Sigma intracellular receptor 2 Tmem97 110.8 102.1 78.6 124.4 126 130 0.766298633017876 0.0385475126349456 -0.384021362772705 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- B7ZMP1 Xaa-Pro aminopeptidase 3 Xpnpep3 142.8 135.1 123.1 132.1 133.6 131.5 1.00956696878147 0.846079637520179 0.0137366138139085 Nonsignificant None 2 Molecular Function:aminopeptidase activity (GO:0004177),Molecular Function:manganese ion binding (GO:0030145) Xaa-Pro aminopeptidase 3.4.11.9 -- Putative Xaa-Pro aminopeptidase E Amino acid transport and metabolism ; IPR000994 [Peptidase M24] ; IPR007865[Aminopeptidase P, N-terminal] -- -- O88693 Ceramide glucosyltransferase Ugcg 137.2 118.8 111.8 128.2 124.2 136.1 0.946718146718147 0.454669583196858 -0.0789931188831348 Nonsignificant None -- -- ceramide glucosyltransferase 2.4.1.80 ko00600 Sphingolipid metabolism ko01100 Metabolic pathways Ceramide glucosyltransferase IM Lipid transport and metabolism ; Cell wall/membrane/envelope biogenesis ; IPR025993 [Ceramide glucosyltransferase] -- -- P53690 Matrix metalloproteinase-14 Mmp14 194.8 173.5 147.8 179.9 186.2 188.7 0.930245133381399 0.403980653597602 -0.104317157039553 Nonsignificant None 4 Molecular Function:metalloendopeptidase activity (GO:0004222),Biological Process:proteolysis (GO:0006508),Molecular Function:zinc ion binding (GO:0008270),Cellular Component:extracellular matrix (GO:0031012) matrix metalloproteinase-14 (membrane-inserted) 3.4.24.80 ko04668 TNF signaling pathway ko04912 GnRH signaling pathway Gelatinase A and related matrix metalloproteases OW Posttranslational modification, protein turnover, chaperones ; Extracellular structures ; IPR001818 [Peptidase M10, metallopeptidase] ; IPR002477[Peptidoglycan binding-like] ; IPR018487[Hemopexin-like repeats] ; IPR021805[Peptidase M10A, matrix metallopeptidase, C-terminal] -- -- Q923D3 Prostate androgen-regulated mucin-like protein 1 homolog Parm1 36.8 39.5 87.6 94.4 83.2 96.2 0.598612125639153 0.0973814425550845 -0.740306592158441 Nonsignificant None -- -- -- -- -- -- -- -- IPR031431 [Prostate androgen-regulated mucin-like protein 1] -- -- Q9D1K7 UPF0687 protein C20orf27 homolog 265.6 265.8 436.6 379 396.9 403.2 0.820965142905606 0.341825440892697 -0.284607126507658 Nonsignificant None -- -- -- -- -- -- -- -- IPR026794 [Uncharacterised protein family UPF0687] -- -- Q8BFW6 Ectonucleoside triphosphate diphosphohydrolase 3 Entpd3 78.1 80.3 73.1 92.4 83.2 106.9 0.819469026548672 0.0781189483257335 -0.287238674042314 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) apyrase 3.6.1.5 ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko05169 Epstein-Barr virus infection Nucleoside phosphatase F Nucleotide transport and metabolism ; IPR000407 [Nucleoside phosphatase GDA1/CD39] -- -- D3YWD5 Major facilitator superfamily domain-containing protein 10 (Fragment) Mfsd10 162.4 164.9 171.2 149.8 128.4 130.4 1.22001957905042 0.0148563631763445 0.286904300552331 Nonsignificant None 2 Cellular Component:integral component of membrane (GO:0016021),Biological Process:transmembrane transport (GO:0055085) -- -- -- Permease of the major facilitator superfamily R General function prediction only ; IPR011701 [Major facilitator superfamily] -- -- Q545K0 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Ndufa1 107.1 95.3 118.4 123.7 112.8 127.8 0.880592917924787 0.145333271374299 -0.183452853287862 Nonsignificant None -- -- NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease -- -- -- IPR017384 [NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex subunit 1] -- -- P81122 Insulin receptor substrate 2 Irs2 65.9 77.9 75.3 73.7 60.7 70.8 1.067738791423 0.436685209963168 0.0945587533831683 Nonsignificant None 1 Molecular Function:insulin receptor binding (GO:0005158) insulin receptor substrate 2 -- ko04022 cGMP-PKG signaling pathway ko04068 FoxO signaling pathway ko04140 Autophagy - animal ko04152 AMPK signaling pathway ko04211 Longevity regulating pathway ko04213 Longevity regulating pathway - multiple species ko04910 Insulin signaling pathway ko04920 Adipocytokine signaling pathway ko04923 Regulation of lipolysis in adipocytes ko04930 Type II diabetes mellitus ko04931 Insulin resistance ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05206 MicroRNAs in cancer -- -- -- IPR001849 [Pleckstrin homology domain] ; IPR002404[IRS-type PTB domain] -- -- Q3UJF5 DNA topoisomerase Top3b 16.7 20.1 22.8 18.9 13.1 18.2 1.18725099601594 0.285011215844443 0.24762496651139 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Molecular Function:DNA topoisomerase activity (GO:0003916),Biological Process:DNA topological change (GO:0006265) DNA topoisomerase III 5.99.1.2 ko03440 Homologous recombination ko03460 Fanconi anemia pathway DNA topoisomerase III beta L Replication, recombination and repair ; IPR006171 [TOPRIM domain] ; IPR013497[DNA topoisomerase, type IA, central] -- -- A0A2R8VHI2 Intraflagellar transport protein 27 homolog Ift27 6.3 6 11 8.1 12 10.4 0.763934426229508 0.291198897081681 -0.388479287795968 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) intraflagellar transport protein 27 -- -- GTP-binding protein H-ray, small G protein superfamily R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- F6WPC3 E3 ubiquitin-protein ligase makorin-1 (Fragment) Mkrn1 22 20.4 13.7 19.9 15.6 16 1.08932038834951 0.623655202814892 0.123428338538212 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) E3 ubiquitin-protein ligase makorin 2.3.2.27 -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR000571 [Zinc finger, CCCH-type] -- -- I6L9D6 Dystrobrevin Dtna 108.8 94 95.6 99.3 97.9 110.7 0.969145826567067 0.636345947948121 -0.0452143317895796 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) -- -- -- Beta-dystrobrevin Z Cytoskeleton ; IPR000433 [Zinc finger, ZZ-type] ; IPR015153[EF-hand domain, type 1] ; IPR015154[EF-hand domain, type 2] -- -- F6S4B9 Histone acetyltransferase (Fragment) Kat7 128.2 202.5 243.7 202.1 196.9 191 0.973559322033898 0.892094713694164 -0.0386592053135145 Nonsignificant None -- -- histone acetyltransferase MYST2 2.3.1.48 -- Histone acetyltransferase (MYST family) B Chromatin structure and dynamics ; IPR002717 [Histone acetyltransferase domain, MYST-type] -- -- Q9R210 Transcription factor EB Tfeb 123.2 120.9 156.9 198.4 188.4 126.1 0.781828816533437 0.216415151882896 -0.355075334635035 Nonsignificant None 1 Molecular Function:protein dimerization activity (GO:0046983) transcription factor EB -- ko04137 Mitophagy - animal Helix loop helix transcription factor EB K Transcription ; IPR011598 [Myc-type, basic helix-loop-helix (bHLH) domain] ; IPR021802[MiT/TFE transcription factors, C-terminal] ; IPR031867[MiT/TFE transcription factors, N-terminal] -- bHLH Q9D0D4 Probable dimethyladenosine transferase Dimt1 83 90.7 117.3 87.1 115.2 88.5 1.00068775790922 0.996387289803374 0.000991883876051825 Nonsignificant None -- -- 18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase 2.1.1.183 -- Ribosomal RNA adenine dimethylase A RNA processing and modification ; IPR001737 [Ribosomal RNA adenine methyltransferase KsgA/Erm] -- -- Q9CQ86 Migration and invasion enhancer 1 Mien1 257.1 244.8 251.7 251.8 268.5 255.9 0.970883792836898 0.288322053896026 -0.0426294681726649 Nonsignificant None -- -- selenoprotein W-related protein -- -- -- -- -- IPR011893 [Selenoprotein, Rdx type] -- -- Q9D8M3 Heme transporter HRG1 Slc48a1 10.5 12.6 7.4 11.2 13.4 11.1 0.854341736694678 0.362155945358556 -0.227114831578851 Nonsignificant None 2 Molecular Function:heme transporter activity (GO:0015232),Biological Process:heme transport (GO:0015886) solute carrier family 48 (heme transporter), member 1 -- -- -- -- -- IPR026218 [Heme transporter HRG] -- -- A0A2I3BPN8 Ral GTPase-activating protein subunit alpha-2 Ralgapa2 71.1 70.3 79.4 87.9 106.5 85.9 0.787727434891188 0.0506302940870451 -0.344231572254325 Nonsignificant None 2 Molecular Function:GTPase activator activity (GO:0005096),Biological Process:regulation of small GTPase mediated signal transduction (GO:0051056) -- -- -- Rap1-GTPase-activating protein (Rap1GAP) T Signal transduction mechanisms ; IPR000331 [Rap GTPase activating protein domain] -- -- A0A1W2P7Q0 Transmembrane protein 19 (Fragment) Tmem19 184.4 194 235.7 209.6 225.2 223.8 0.932432432432432 0.419882617532187 -0.100928908850781 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) -- -- -- Predicted membrane protein S Function unknown ; IPR002794 [Protein of unknown function DUF92, TMEM19] -- -- Q8BMY1 G domain-containing protein Noa1 84.7 77.5 77.8 76.7 86.5 82.6 0.97640358014646 0.628356598875953 -0.0344505098767809 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) nitric oxide-associated protein 1 -- -- Predicted GTPases R General function prediction only ; IPR006073 [GTP binding domain] -- -- Q921I6 SH3 domain-binding protein 4 Sh3bp4 35.4 33.4 36 28.3 31.1 31.6 1.15164835164835 0.0236448774695645 0.203700266451392 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) SH3 domain-binding protein 4 -- -- -- -- -- IPR000906 [ZU5 domain] ; IPR001452[SH3 domain] ; IPR011511[Variant SH3 domain] -- -- Q8BPS4 Integral membrane protein GPR180 Gpr180 417.6 399.4 355.3 330.1 324.8 359.8 1.15531684241648 0.0706329424167172 0.208288560989479 Nonsignificant None 2 Biological Process:G-protein coupled receptor signaling pathway (GO:0007186),Biological Process:response to pheromone (GO:0019236) -- -- -- Predicted membrane protein S Function unknown ; IPR019336 [Intimal thickness related receptor, IRP] -- -- O55100 Synaptogyrin-1 Syngr1 42.7 38.7 44.8 77.3 52.6 63.4 0.652871184687015 0.0385889677273026 -0.615129727228687 Significant down 1 Cellular Component:membrane (GO:0016020) -- -- -- Synaptic vesicle protein Synaptogyrin involved in regulation of Ca2+-dependent exocytosis TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR008253 [Marvel domain] -- -- Q9D6K8 FUN14 domain-containing protein 2 Fundc2 520.1 434.1 395.9 397.3 367.3 399.7 1.15958086403848 0.180076765142755 0.213603430660461 Nonsignificant None -- -- -- -- -- Predicted membrane protein S Function unknown ; IPR007014 [FUN14] -- -- A2AGL8 E3 ubiquitin-protein ligase RNF128 Rnf128 185.2 181 158 106.2 113.7 120.9 1.5381455399061 0.00295240003752172 0.621192018102579 Significant up 2 Molecular Function:protein binding (GO:0005515),Molecular Function:zinc ion binding (GO:0008270) E3 ubiquitin-protein ligase RNF128 2.3.2.27 -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR001841 [Zinc finger, RING-type] ; IPR003137[PA domain] -- -- Q6ZPZ8 MKIAA1031 protein (Fragment) mKIAA1031 38.5 45.9 45.9 41.9 45.3 42.2 1.00695517774343 0.916741318986424 0.00999946657562684 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR019734 [Tetratricopeptide repeat] -- -- Q9CXV1 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial Sdhd 145.1 122 120.9 173.4 190.1 210.4 0.676075971423593 0.00957690891466795 -0.564742721992778 Nonsignificant None -- -- succinate dehydrogenase (ubiquinone) membrane anchor subunit -- ko00020 Citrate cycle (TCA cycle) ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko01200 Carbon metabolism ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Succinate dehydrogenase membrane anchor subunit and related proteins CU Energy production and conversion ; Intracellular trafficking, secretion, and vesicular transport ; -- -- -- Q9D3D0 Alpha-tocopherol transfer protein-like Ttpal 10.3 14.3 9.9 12.8 12.5 12.4 0.915119363395225 0.52729774492022 -0.127968161603133 Nonsignificant None -- -- -- -- -- Phosphatidylinositol transfer protein SEC14 and related proteins I Lipid transport and metabolism ; IPR001251 [CRAL-TRIO lipid binding domain] ; IPR011074[CRAL/TRIO, N-terminal domain] -- -- Q5Y5T1 Palmitoyltransferase ZDHHC20 Zdhhc20 147 146.6 160.7 155.3 168.7 150.7 0.957025489783021 0.393369534950553 -0.0633707443726894 Nonsignificant None -- -- palmitoyltransferase ZDHHC2/15/20 2.3.1.225 -- Predicted DHHC-type Zn-finger protein R General function prediction only ; IPR001594 [Palmitoyltransferase, DHHC domain] -- -- Q3TBW1 Inositol-polyphosphate 5-phosphatase Inpp5j 39.6 33.4 46.4 57.2 58.3 57.5 0.690173410404624 0.0405071380965902 -0.534969201259282 Nonsignificant None -- -- inositol-1,4,5-trisphosphate 5-phosphatase 3.1.3.56 ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system Inositol polyphosphate 5-phosphatase and related proteins U Intracellular trafficking, secretion, and vesicular transport ; -- -- -- Q99KK1 Receptor expression-enhancing protein 3 Reep3 95.2 141.6 183.8 165.7 157.5 165.7 0.8602986295766 0.46782176103196 -0.217090555276358 Nonsignificant None -- -- receptor expression-enhancing protein 1/2/3/4 -- -- HVA22/DP1 gene product-related proteins V Defense mechanisms ; IPR004345 [TB2/DP1/HVA22-related protein] -- -- E0CXR5 Cerebral cavernous malformations protein 2 homolog (Fragment) Ccm2 115.6 147.1 125.8 130.5 155.1 129.4 0.936144578313253 0.519068894282795 -0.0951967378265772 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- F6RXL0 Cyclin-L2 (Fragment) Ccnl2 273.5 264.7 229.7 201.5 209 224.6 1.20910092898756 0.0419852869180639 0.273934677732052 Nonsignificant None -- -- -- -- -- Cyclin L R General function prediction only ; -- -- -- F8VPR2 Formin-like protein 2 Fmnl2 97.3 140.7 156.3 135.3 131.2 141.3 0.966895537027955 0.813821593101842 -0.0485680649087801 Nonsignificant None 4 Molecular Function:actin binding (GO:0003779),Biological Process:cellular component organization (GO:0016043),Molecular Function:Rho GTPase binding (GO:0017048),Biological Process:actin cytoskeleton organization (GO:0030036) -- -- -- Rac1 GTPase effector FRL TZ Signal transduction mechanisms ; Cytoskeleton ; IPR010472 [Formin, FH3 domain] ; IPR010473[Formin, GTPase-binding domain] ; IPR015425[Formin, FH2 domain] -- -- Q9JJD0 THAP domain-containing protein 11 Thap11 68.5 51.1 45.3 53.1 43.6 56.2 1.07848266841073 0.640679587072731 0.109002992076663 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- -- -- -- IPR006612 [Zinc finger, C2CH-type] -- THAP Q8BGA5 KRR1 small subunit processome component homolog Krr1 269.3 247.9 306.6 280.5 274.7 282.8 0.983054892601432 0.809397640373057 -0.024656117718457 Nonsignificant None -- -- ribosomal RNA assembly protein -- -- rRNA processing protein JD Translation, ribosomal structure and biogenesis ; Cell cycle control, cell division, chromosome partitioning ; -- -- -- Q9CWX4 Pseudouridylate synthase RPUSD4, mitochondrial Rpusd4 115.7 109.9 119.2 123.7 119.4 134.2 0.913861648555526 0.103944339615784 -0.129952325721011 Nonsignificant None 4 Biological Process:pseudouridine synthesis (GO:0001522),Molecular Function:RNA binding (GO:0003723),Biological Process:RNA modification (GO:0009451),Molecular Function:pseudouridine synthase activity (GO:0009982) RNA pseudouridylate synthases A RNA processing and modification ; IPR006145 [Pseudouridine synthase, RsuA/RluB/C/D/E/F] -- -- D3Z132 THO complex subunit 6 homolog Thoc6 75 69.8 96.2 69.6 83.2 75.6 1.05516637478109 0.664406241458845 0.0774704957544811 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) THO complex subunit 6 -- ko03013 RNA transport WD40 repeat protein R General function prediction only ; IPR001680 [WD40 repeat] -- -- B1AYC9 Amyloid beta (A4) protein-binding, family B, member 1 interacting protein Apbb1ip 130 148.3 143.7 100.5 124.4 109.2 1.26309488177192 0.0300211374259487 0.336963016259577 Nonsignificant None 1 Biological Process:signal transduction (GO:0007165) amyloid beta A4 precursor protein-binding family B member 1-interacting protein -- ko04015 Rap1 signaling pathway ko04611 Platelet activation Growth factor receptor-bound proteins (GRB7, GRB10, GRB14) T Signal transduction mechanisms ; IPR000159 [Ras-associating (RA) domain] ; IPR001849[Pleckstrin homology domain] -- -- F2Z4B3 Cyclin-dependent kinase 2-associated protein 1 Cdk2ap1 108 135.7 126.4 147.4 160.1 138.1 0.83056552962298 0.0716598459654886 -0.267834097039811 Nonsignificant None -- -- -- -- -- Cyclin-dependent kinase 2-associated protein TD Signal transduction mechanisms ; Cell cycle control, cell division, chromosome partitioning ; IPR017266 [Cyclin-dependent kinase 2-associated protein 1/2] -- -- Q9D0Y8 39S ribosomal protein L52, mitochondrial Mrpl52 11.8 13.1 10.7 13.4 24.3 15.5 0.669172932330827 0.160480204600251 -0.579549004534792 Nonsignificant None -- -- large subunit ribosomal protein L52 -- -- -- -- -- -- -- -- Q32NZ6 Transmembrane channel-like protein 5 Tmc5 15.9 14.5 14.6 25.2 19.3 16.2 0.741350906095552 0.122355768661485 -0.431771515038645 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) transmembrane channel-like protein -- -- -- -- -- IPR012496 [TMC] -- -- A0A087WQV4 Maturin Mturn 49.9 47.8 55 62.9 52.1 69.9 0.825851811790157 0.127825872810693 -0.276045162607344 Nonsignificant None -- -- -- -- -- -- -- -- IPR027892 [Protein of unknown function DUF4581] -- -- P59110 Sentrin-specific protease 1 Senp1 63 49.4 64 58.2 60.5 72.8 0.921148825065274 0.484179948292471 -0.118493831254799 Nonsignificant None 2 Biological Process:proteolysis (GO:0006508),Molecular Function:cysteine-type peptidase activity (GO:0008234) sentrin-specific protease 1 3.4.22.68 -- Protease, Ulp1 family O Posttranslational modification, protein turnover, chaperones ; IPR003653 [Ulp1 protease family, C-terminal catalytic domain] -- -- Q8BSM7 Large neutral amino acids transporter small subunit 3 Slc43a1 104.2 100.1 82.4 106.2 92.2 101.9 0.954711954711955 0.595304940294489 -0.0668625703166263 Nonsignificant None 2 Cellular Component:integral component of membrane (GO:0016021),Biological Process:transmembrane transport (GO:0055085) MFS transporter, LAT3 family, solute carrier family 43, member 1 -- -- -- -- -- IPR011701 [Major facilitator superfamily] -- -- Q8K1G9 RNA helicase Dhx35 58.3 60.2 43.4 48.8 61.8 57.3 0.964264443120905 0.774929453851094 -0.052499244634464 Nonsignificant None 1 Molecular Function:helicase activity (GO:0004386) ATP-dependent RNA helicase DDX35 3.6.4.13 -- DEAH-box RNA helicase A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR007502[Helicase-associated domain] ; IPR011709[Domain of unknown function DUF1605] -- -- Q8BIR6 Sema domain-containing protein Sema4b 410.8 363.1 418.2 469.7 447.5 466 0.861842105263158 0.0265805058511955 -0.214504511906135 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:membrane (GO:0016020) semaphorin 4 -- ko04360 Axon guidance Semaphorins T Signal transduction mechanisms ; IPR001627 [Sema domain] ; IPR002165[Plexin repeat] -- -- P28481 Collagen alpha-1(II) chain Col2a1 182.9 184.2 229.4 198.8 226.7 216.5 0.929127725856698 0.430761791082967 -0.106051159427075 Nonsignificant None 2 Molecular Function:extracellular matrix structural constituent (GO:0005201),Molecular Function:protein binding (GO:0005515) collagen, type II, alpha -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04974 Protein digestion and absorption ko05165 Human papillomavirus infection Collagens (type IV and type XIII), and related proteins W Extracellular structures ; IPR000885 [Fibrillar collagen, C-terminal] ; IPR001007[VWFC domain] ; IPR008160[Collagen triple helix repeat] -- -- Q3U1T3 Breast cancer metastasis-suppressor 1-like protein Brms1l 40.2 40.7 29.4 44.8 42.5 47.2 0.820074349442379 0.109236515235169 -0.286173381852604 Nonsignificant None -- -- breast cancer metastasis-suppressor 1 and related proteins -- -- Component of histone deacetylase complex (breast carcinoma metastasis suppressor 1 protein in human) DK Cell cycle control, cell division, chromosome partitioning ; Transcription ; IPR013907 [Sds3-like] -- -- H3BIX7 Calcium-transporting ATPase Atp2c1 216.1 197.2 232.4 236.7 236.6 254 0.887804207342225 0.0807110915873708 -0.171686549214466 Nonsignificant None 2 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:metal ion binding (GO:0046872) Ca2+-transporting ATPase 3.6.3.8 -- Ca2+ transporting ATPase P Inorganic ion transport and metabolism ; IPR006068 [Cation-transporting P-type ATPase, C-terminal] ; IPR008250[P-type ATPase, A domain] -- -- I3PQW8 TIFA Tifa 93.1 102.7 91.5 41.1 48.6 56.7 1.96243169398907 0.00118522085059374 0.972642439248481 Significant up 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR000253 [Forkhead-associated (FHA) domain] -- -- Q8BQY8 Checkpoint protein HUS1 Hus1 19.1 15.6 21.7 22.4 25.4 18.8 0.846846846846847 0.261170882704603 -0.239827014672469 Nonsignificant None 2 Biological Process:DNA damage checkpoint (GO:0000077),Cellular Component:checkpoint clamp complex (GO:0030896) HUS1 checkpoint protein -- ko04218 Cellular senescence Checkpoint 9-1-1 complex, HUS1 component DL Cell cycle control, cell division, chromosome partitioning ; Replication, recombination and repair ; IPR007150 [Checkpoint protein Hus1/Mec3] -- -- B1AXZ5 ELAV-like protein Elavl2 97.1 81.6 209.4 217 186.4 174 0.672151021821961 0.209561986685784 -0.573142674450534 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) ELAV like protein 2/3/4 -- -- RNA-binding protein ELAV/HU (RRM superfamily) A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- O70562 Small proline-rich protein 2K Sprr2k 196.9 267.5 222.6 201.5 161.9 176.3 1.27292940522512 0.106535697394332 0.348152411732824 Nonsignificant None 1 Cellular Component:cornified envelope (GO:0001533) -- -- -- -- -- -- IPR029142 [Small proline-rich protein 2] -- -- Q8BXL7 ADP-ribosylation factor-related protein 1 Arfrp1 119 131.6 140.7 134.3 137.3 140.6 0.949296458030082 0.347394220981044 -0.0750693946384622 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) ADP-ribosylation factor related protein 1 -- -- GTP-binding ADP-ribosylation factor-like protein yARL3 U Intracellular trafficking, secretion, and vesicular transport ; IPR006689 [Small GTPase superfamily, ARF/SAR type] -- -- Q7TQE1 Mediator of RNA polymerase II transcription subunit 15 Med15 29.6 32.4 41.8 36.2 38.3 36.4 0.935978358881876 0.562214528555237 -0.0954529218038292 Nonsignificant None 3 Molecular Function:RNA polymerase II transcription cofactor activity (GO:0001104),Biological Process:regulation of transcription from RNA polymerase II promoter (GO:0006357),Cellular Component:mediator complex (GO:0016592) mediator of RNA polymerase II transcription subunit 15 -- -- Positive cofactor 2 (PC2), subunit of a multiprotein coactivator of RNA polymerase II K Transcription ; IPR019087 [Mediator of RNA polymerase II transcription subunit 15] -- -- O35684 Neuroserpin Serpini1 5.8 9.3 5.8 15.1 15.1 10.6 0.512254901960784 0.0251071061485754 -0.965066209890613 Significant down -- -- -- -- -- Serpin V Defense mechanisms ; IPR023796 [Serpin domain] -- -- Q3UH53 Protein sidekick-1 Sdk1 89.2 82 62.9 71.6 69.2 66.3 1.13037180106229 0.323268774902924 0.176797380891501 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) protein sidekick -- -- FOG: Immunoglobulin C-2 Type/fibronectin type III domains T Signal transduction mechanisms ; IPR003961 [Fibronectin type III] ; IPR013098[Immunoglobulin I-set] -- -- E9Q1R2 4-hydroxy-2-oxoglutarate aldolase, mitochondrial Hoga1 109.7 95.3 103 115.2 118.5 117.7 0.876494023904382 0.0277297361127637 -0.190183840426112 Nonsignificant None 2 Biological Process:metabolic process (GO:0008152),Molecular Function:lyase activity (GO:0016829) 4-hydroxy-2-oxoglutarate aldolase 4.1.3.16 ko00330 Arginine and proline metabolism ko00630 Glyoxylate and dicarboxylate metabolism ko01100 Metabolic pathways -- -- -- IPR002220 [DapA-like] -- -- H3BL03 AP-4 complex subunit epsilon-1 Ap4e1 69.6 73.6 80 84.9 76.2 79 0.929612661391087 0.228747282584131 -0.105298376401229 Nonsignificant None 3 Biological Process:intracellular protein transport (GO:0006886),Biological Process:vesicle-mediated transport (GO:0016192),Cellular Component:membrane coat (GO:0030117) AP-4 complex subunit epsilon-1 -- ko04142 Lysosome Vesicle coat complex AP-1, gamma subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR002553 [Clathrin/coatomer adaptor, adaptin-like, N-terminal] -- -- E9Q6A6 Collagen alpha-6(VI) chain Col6a6 52.8 58.3 48.9 54.8 67.5 61.8 0.86909288430201 0.153884947297918 -0.202417721575182 Nonsignificant None -- -- collagen, type VI, alpha -- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko04974 Protein digestion and absorption ko05165 Human papillomavirus infection Collagens (type IV and type XIII), and related proteins W Extracellular structures ; IPR002035 [von Willebrand factor, type A] ; IPR008160[Collagen triple helix repeat] -- -- G5E8L8 Mitogen-activated protein kinase kinase kinase 2 Map3k2 218.6 230.5 189.9 184.2 200 209.9 1.07557650227234 0.350886410155137 0.105110142635195 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein binding (GO:0005515),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) mitogen-activated protein kinase kinase kinase 2 2.7.11.25 ko04010 MAPK signaling pathway ko04540 Gap junction ko04912 GnRH signaling pathway MEKK and related serine/threonine protein kinases T Signal transduction mechanisms ; IPR000270 [PB1 domain] ; IPR000719[Protein kinase domain] -- -- Q3TMK4 Ecotropic viral integration site 5 protein (Fragment) Evi5 28.3 18.8 17.6 20.6 30.9 22.6 0.873144399460189 0.53532923324027 -0.195707830313326 Nonsignificant None -- -- ecotropic viral integration site 5 protein -- -- Predicted GTPase activator NB4S/EVI5 (contains TBC domain)/Calmodulin-binding protein Pollux (contains PTB and TBC domains) R General function prediction only ; IPR000195 [Rab-GTPase-TBC domain] -- -- Q9JHZ2 Progressive ankylosis protein Ankh 15.4 13 25.8 24.6 12 18 0.992673992673993 0.981326675603676 -0.0106080995659809 Nonsignificant None 3 Molecular Function:phosphate ion transmembrane transporter activity (GO:0015114),Cellular Component:integral component of membrane (GO:0016021),Biological Process:phosphate ion transmembrane transport (GO:0035435) -- -- -- -- -- -- IPR009887 [Progressive ankylosis] -- -- A0A0A6YWF7 Protein lin-9 homolog Lin9 23.4 20.9 14.3 18.9 23.9 24.6 0.869436201780415 0.418325469359406 -0.201847926759611 Nonsignificant None -- -- protein lin-9 -- ko04218 Cellular senescence Retinoblastoma pathway protein LIN-9/chromatin-associated protein Aly BDT Chromatin structure and dynamics ; Cell cycle control, cell division, chromosome partitioning ; Signal transduction mechanisms ; IPR033471 [DIRP domain] -- -- Q3TLS3 GDP-D-glucose phosphorylase 1 Gdpgp1 32.4 29.1 37.4 38.5 31.1 42.8 0.879893238434164 0.342561256222552 -0.184599609461815 Nonsignificant None -- -- GDP-D-glucose phosphorylase 2.7.7.78 -- Predicted hydrolase (HIT family) R General function prediction only ; -- -- -- Q8BZR9 Nuclear cap-binding protein subunit 3 Ncbp3 17.2 16.2 15.9 18.9 19.1 12.4 0.978174603174603 0.877673485311014 -0.031836087122005 Nonsignificant None 2 Molecular Function:RNA 7-methylguanosine cap binding (GO:0000340),Molecular Function:mRNA binding (GO:0003729) -- -- -- -- -- -- IPR019416 [Nuclear cap-binding protein subunit 3] -- -- Q62356 Follistatin-related protein 1 Fstl1 186.2 187.3 207.2 186.4 193.6 153.3 1.08888055503469 0.327045714965488 0.122845706019695 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR002350 [Kazal domain] ; IPR015369[Follistatin/Osteonectin EGF domain] -- -- Q5SXC4 Vascular endothelial zinc finger 1 Vezf1 256.8 182.7 184.9 173.6 194.7 232.5 1.0392809587217 0.804977192995291 0.0555857244636371 Nonsignificant None -- -- -- -- -- FOG: Zn-finger R General function prediction only ; -- -- zf-C2H2 Q06180 Tyrosine-protein phosphatase non-receptor type 2 Ptpn2 55.6 64.2 60.2 82 103.4 79.8 0.678733031674208 0.0231057748960768 -0.559083868895551 Nonsignificant None 2 Molecular Function:protein tyrosine phosphatase activity (GO:0004725),Biological Process:protein dephosphorylation (GO:0006470) tyrosine-protein phosphatase non-receptor type 2 3.1.3.48 ko04630 Jak-STAT signaling pathway Protein tyrosine phosphatase T Signal transduction mechanisms ; IPR000242 [PTP type protein phosphatase] -- -- G3X9L9 Myomegalin Pde4dip 131.1 152.8 153.9 121.3 129.2 184.1 1.00736309249885 0.962101748696381 0.0105837799996632 Nonsignificant None 1 Cellular Component:microtubule organizing center (GO:0005815) myomegalin -- -- -- -- -- IPR010630 [Neuroblastoma breakpoint family (NBPF) domain] ; IPR012943[Centrosomin, N-terminal motif 1] -- -- Q9DCN1 NAD-capped RNA hydrolase NUDT12 Nudt12 45 48 53.9 53.1 41.6 48.7 1.02440725244073 0.797261451952739 0.0347893718543752 Nonsignificant None 2 Molecular Function:hydrolase activity (GO:0016787),Molecular Function:metal ion binding (GO:0046872) NAD+ diphosphatase 3.6.1.22 ko00760 Nicotinate and nicotinamide metabolism ko01100 Metabolic pathways ko04146 Peroxisome FOG: Ankyrin repeat R General function prediction only ; IPR000086 [NUDIX hydrolase domain] ; IPR015375[NADH pyrophosphatase-like, N-terminal] ; IPR015376[Zinc ribbon, NADH pyrophosphatase] ; IPR020683[Ankyrin repeat-containing domain] -- -- Q9D975 Sulfiredoxin-1 Srxn1 208.9 217.8 168.1 167.7 167.1 166.4 1.18675179569034 0.178206941827809 0.247018232730558 Nonsignificant None -- -- sulfiredoxin 1.8.98.2 -- Predicted transcription regulator/nuclease, contains ParB domain L Replication, recombination and repair ; IPR003115 [ParB/Sulfiredoxin] -- -- Q8BNF7 Uncharacterized protein (Fragment) Herc1 4.5 5.2 0 3.7 4.2 2.6 1.38571428571429 0.134750646882544 0.470629825242161 Nonsignificant None -- -- E3 ubiquitin-protein ligase HERC1 2.3.2.26 ko04120 Ubiquitin mediated proteolysis FOG: RCC1 domain S Function unknown ; IPR000408 [Regulator of chromosome condensation, RCC1] -- -- F7BE84 Ankyrin repeat domain 50 (Fragment) Ankrd50 98.9 90.3 87.1 70.6 78.2 84 1.18685567010309 0.050500494169194 0.247144503904208 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) ankyrin repeat domain-containing protein 50 -- -- FOG: Ankyrin repeat R General function prediction only ; IPR002110 [Ankyrin repeat] ; IPR020683[Ankyrin repeat-containing domain] -- -- Q9EP71 Ankycorbin Rai14 115.9 103.5 102.8 101.4 105.8 106.9 1.02578796561605 0.586774515831901 0.0367325510546041 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR002110 [Ankyrin repeat] ; IPR020683[Ankyrin repeat-containing domain] -- -- Q9QXA1 Cysteine and histidine-rich protein 1 Cyhr1 243.6 215.3 225.3 205.8 217.3 217.9 1.06739469578783 0.19156648162828 0.0940937472617961 Nonsignificant None -- -- -- -- -- Zn finger protein R General function prediction only ; -- -- -- Q05909 Receptor-type tyrosine-protein phosphatase gamma Ptprg 62.1 62.6 79.4 67 80.4 67 0.951958955223881 0.659641238864455 -0.0710287234250534 Nonsignificant None 3 Molecular Function:protein tyrosine phosphatase activity (GO:0004725),Molecular Function:protein binding (GO:0005515),Biological Process:protein dephosphorylation (GO:0006470) receptor-type tyrosine-protein phosphatase gamma 3.1.3.48 -- Protein tyrosine phosphatase T Signal transduction mechanisms ; IPR000242 [PTP type protein phosphatase] ; IPR001148[Alpha carbonic anhydrase] ; IPR003961[Fibronectin type III] -- -- Q9CQJ2 PIH1 domain-containing protein 1 Pih1d1 268.8 294.6 342.6 287.2 313.7 274.1 1.03542857142857 0.695575399922783 0.0502280333265439 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR012981 [PIH1 family] -- -- A0A0R4J114 U3 small nucleolar RNA-associated protein 25 homolog Utp25 371.3 351.8 273.7 227.3 251.2 219.6 1.42787566251253 0.0335024976356185 0.513870356897497 Nonsignificant None 1 Cellular Component:nucleus (GO:0005634) U3 small nucleolar RNA-associated protein 25 -- -- Uncharacterized conserved protein S Function unknown ; IPR010678 [Digestive organ expansion factor, predicted] -- -- G8JL51 DNA-directed RNA polymerase I subunit RPA49 (Fragment) Polr1e 207.7 212.3 162.9 139 134.3 146.7 1.38785714285714 0.0283298393521282 0.472859073753016 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Molecular Function:DNA-directed 5'-3' RNA polymerase activity (GO:0003899),Cellular Component:nucleus (GO:0005634) DNA-directed RNA polymerase I subunit RPA49 -- ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways ko03020 RNA polymerase RNA polymerase I 49 kDa subunit K Transcription ; IPR009668 [RNA polymerase I associated factor, A49-like] -- -- Q6PAC3 DDB1- and CUL4-associated factor 13 Dcaf13 425.7 402 362.4 348.4 358.4 345.5 1.13095124964364 0.0716873796260849 0.177536742401833 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) WD repeat and SOF domain-containing protein 1 -- -- Sof1-like rRNA processing protein (contains WD40 repeats) A RNA processing and modification ; IPR001680 [WD40 repeat] ; IPR007287[Sof1-like protein] -- -- A2AGQ2 MAP kinase-activating death domain protein Madd 24.2 15.8 22 8.8 16.2 14.3 1.57760814249364 0.0870488246674698 0.657738903015631 Nonsignificant None -- -- -- -- -- MAPK-activating protein DENN T Signal transduction mechanisms ; IPR001194 [DENN domain] ; IPR005113[uDENN domain] -- -- Q9D517 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma Agpat3 54.2 45.2 60.7 66.6 71.8 72.9 0.75769048745859 0.0252146894290371 -0.400319459418684 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) -- -- ko00561 Glycerolipid metabolism ko00564 Glycerophospholipid metabolism ko01100 Metabolic pathways ko04072 Phospholipase D signaling pathway Lysophosphatidic acid acyltransferase LPAAT and related acyltransferases I Lipid transport and metabolism ; IPR002123 [Phospholipid/glycerol acyltransferase] ; IPR032098[Acyltransferase, C-terminal domain] -- -- Q9WUH7 Semaphorin-4G Sema4g 124.5 120.5 131.1 147.8 170.4 161.6 0.783868278449354 0.00892694270771258 -0.351316851253128 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:membrane (GO:0016020) semaphorin 4 -- ko04360 Axon guidance Semaphorins T Signal transduction mechanisms ; IPR001627 [Sema domain] ; IPR002165[Plexin repeat] -- -- Q3TR55 Uncharacterized protein Smyd3 43.1 43.9 42.9 53.3 50.4 56.8 0.809345794392523 0.00554598946150569 -0.305171866561785 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) SET and MYND domain-containing protein -- -- Predicted histone tail methylase containing SET domain B Chromatin structure and dynamics ; IPR001214 [SET domain] ; IPR002893[Zinc finger, MYND-type] -- -- Q924W7 DENN domain-containing protein 2B Dennd2b 56.5 48.1 51.4 60 55.9 63.8 0.868113522537563 0.0773761756379398 -0.204044379760331 Nonsignificant None -- -- DENN domain-containing protein 2 -- -- RAS signaling inhibitor ST5 T Signal transduction mechanisms ; IPR001194 [DENN domain] ; IPR005112[dDENN domain] ; IPR005113[uDENN domain] -- -- F6V3V2 Lysine-specific histone demethylase 1B (Fragment) Kdm1b 8 8.3 6.9 8.5 6.8 8.2 0.987234042553192 0.889385678134896 -0.0185359514374275 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) lysine-specific histone demethylase 1B 1.-.-.- -- Amine oxidase Q Secondary metabolites biosynthesis, transport and catabolism ; IPR002937 [Amine oxidase] ; IPR007526[SWIRM domain] -- -- Q5FWJ8 Enpp5 protein (Fragment) Enpp5 21.1 18.3 30.5 43.4 40.3 45.2 0.542280837858805 0.00765378660051184 -0.882887902986214 Significant down 1 Molecular Function:catalytic activity (GO:0003824) ectonucleotide pyrophosphatase/phosphodiesterase family member 5 3.1.-.- -- Type I phosphodiesterase/nucleotide pyrophosphatase R General function prediction only ; IPR002591 [Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase] -- -- Q8R2U7 Leucine-rich repeat-containing protein 42 Lrrc42 240.5 239.4 283 279.9 287.2 265.2 0.916616604589691 0.215677540372271 -0.125609674391997 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR001611 [Leucine-rich repeat] -- -- A0A494B958 Homeobox protein PKNOX1 Pknox1 72.8 119.4 138.5 115.2 120 102.8 0.978402366863905 0.909808184649507 -0.031500200978432 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) -- -- -- Transcription factor MEIS1 and related HOX domain proteins K Transcription ; IPR008422 [Homeobox KN domain] ; IPR032453[Homeobox protein PKNOX/Meis, N-terminal] -- Homeobox Q8BJH7 Uncharacterized protein Pex6 174.1 160.1 162.7 150.6 151.6 158.4 1.07881024750326 0.0708162461338539 0.109441130757264 Nonsignificant None -- -- peroxin-6 -- ko04146 Peroxisome Peroxisome assembly factor 2 containing the AAA+-type ATPase domain O Posttranslational modification, protein turnover, chaperones ; -- -- -- Q3UJY2 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase B3gat3 122.1 105 85.2 117.2 118.7 116.9 0.885204081632653 0.332865853879962 -0.175917991536947 Nonsignificant None 2 Molecular Function:galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity (GO:0015018),Cellular Component:membrane (GO:0016020) galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 2.4.1.135 ko00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin ko01100 Metabolic pathways Beta-1,3-glucuronyltransferase B3GAT1/SQV-8 O Posttranslational modification, protein turnover, chaperones ; IPR005027 [Glycosyl transferase, family 43] -- -- Q80ZW2 Protein THEM6 Them6 69.7 83.3 101.4 83.4 87 85.3 0.99491591709034 0.966763285713559 -0.00735348995729353 Nonsignificant None -- -- -- -- -- Predicted thioesterase R General function prediction only ; -- -- -- F7C1U0 Potassium channel tetramerisation domain-containing 17 (Fragment) Kctd17 49.7 55 50.6 38.7 32.2 29.5 1.54681274900398 0.00454075960032447 0.629298560436529 Significant up -- -- BTB/POZ domain-containing protein KCTD2/5/17 -- -- Uncharacterized conserved protein, contains BTB/POZ domain R General function prediction only ; -- -- -- O35984 Pre-B-cell leukemia transcription factor 2 Pbx2 56.9 58.6 46.2 42.3 44 69.8 1.03587443946188 0.856868597442999 0.050849141495753 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634) pre-B-cell leukemia transcription factor 2 -- -- Transcription factor PBX and related HOX domain proteins K Transcription ; IPR001356 [Homeobox domain] ; IPR005542[PBX] -- Homeobox Q3USC7 Ganglioside-induced differentiation-associated protein 1-like 1 Gdap1l1 173.5 163.1 202.8 221.2 224.1 207.7 0.826033690658499 0.0427290623511876 -0.275727470198189 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) ganglioside-induced differentiation-associated protein 1 -- -- Uncharacterized conserved protein (Ganglioside-induced differentiation associated protein 1, GDAP1) S Function unknown ; IPR004045 [Glutathione S-transferase, N-terminal] -- -- A0A0A6YX50 Protoporphyrinogen oxidase (Fragment) Ppox 122.3 119.7 122.5 136.6 123.8 143.6 0.902227722772277 0.14808630977764 -0.148436478424858 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) -- -- ko00860 Porphyrin and chlorophyll metabolism ko01100 Metabolic pathways Protoporphyrinogen oxidase H Coenzyme transport and metabolism ; IPR002937 [Amine oxidase] -- -- Q3UNW5 Transcription factor CP2-like protein 1 Tfcp2l1 25.9 21.5 28.3 52.1 45.6 52.6 0.503659347970725 0.0011682748651233 -0.989479803930633 Significant down -- -- transcription factor CP2 and related proteins -- -- Transcription factor K Transcription ; IPR007604 [CP2 transcription factor] -- CP2 Q9JM13 Rab5 GDP/GTP exchange factor Rabgef1 77.1 90.3 76.4 83.4 80 71.6 1.03744680851064 0.635200812363618 0.05303736916785 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Molecular Function:zinc ion binding (GO:0008270) Rab5 GDP/GTP exchange factor -- -- Vacuolar assembly/sorting protein VPS9 U Intracellular trafficking, secretion, and vesicular transport ; IPR002653 [Zinc finger, A20-type] ; IPR003123[VPS9 domain] -- -- Q9CQZ0 ORM1-like protein 2 Ormdl2 63.9 74.6 78.9 92 92.2 77.7 0.830087819778542 0.0863097178272634 -0.268664119323287 Nonsignificant None 2 Cellular Component:endoplasmic reticulum membrane (GO:0005789),Cellular Component:integral component of membrane (GO:0016021) -- -- -- Predicted membrane protein S Function unknown ; IPR007203 [ORMDL family] -- -- Q8C0D7 Inhibitor of growth protein 4 Ing4 103.3 101.2 115.4 82.4 86.7 86.7 1.25058639562158 0.0100794435556975 0.322604728234037 Nonsignificant None -- -- inhibitor of growth protein 4 -- -- Chromatin remodeling protein, contains PHD Zn-finger B Chromatin structure and dynamics ; IPR024610 [Inhibitor of growth protein, N-terminal histone-binding] -- -- Q5FWV9 Zbtb7b protein (Fragment) Zbtb7b 78 143.6 158.8 170.1 192.1 140.7 0.756412805726785 0.230803179240945 -0.402754307218221 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) zinc finger and BTB domain-containing protein 7 -- -- FOG: Zn-finger R General function prediction only ; IPR000210 [BTB/POZ domain] -- ZBTB Q9D173 Mitochondrial import receptor subunit TOM7 homolog Tomm7 52.4 38.6 43.4 47 45.8 52 0.92817679558011 0.481149580525506 -0.107528464304445 Nonsignificant None 2 Cellular Component:mitochondrial outer membrane translocase complex (GO:0005742),Biological Process:protein import into mitochondrial matrix (GO:0030150) mitochondrial import receptor subunit TOM7 -- ko04137 Mitophagy - animal Translocase of outer mitochondrial membrane complex, subunit TOM7 U Intracellular trafficking, secretion, and vesicular transport ; IPR012621 [Mitochondrial import receptor subunit TOM7] -- -- Q8CD91 SPARC-related modular calcium-binding protein 2 Smoc2 58.2 95 98.4 77.5 79.5 76 1.07982832618026 0.677950927266333 0.110801967337647 Nonsignificant None 4 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:protein binding (GO:0005515),Cellular Component:proteinaceous extracellular matrix (GO:0005578),Biological Process:signal transduction (GO:0007165) -- -- -- Uncharacterized conserved protein, contains KAZAL and TY domains R General function prediction only ; IPR000716 [Thyroglobulin type-1] ; IPR002350[Kazal domain] ; IPR019577[SPARC/Testican, calcium-binding domain] -- -- Q60992 Guanine nucleotide exchange factor VAV2 Vav2 24.4 30.5 33.8 21.8 25.4 27.8 1.18266666666667 0.23375608687642 0.242043508917821 Nonsignificant None 3 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Biological Process:regulation of Rho protein signal transduction (GO:0035023),Biological Process:intracellular signal transduction (GO:0035556) guanine nucleotide exchange factor VAV -- ko04024 cAMP signaling pathway ko04062 Chemokine signaling pathway ko04510 Focal adhesion ko04650 Natural killer cell mediated cytotoxicity ko04660 T cell receptor signaling pathway ko04662 B cell receptor signaling pathway ko04664 Fc epsilon RI signaling pathway ko04666 Fc gamma R-mediated phagocytosis ko04670 Leukocyte transendothelial migration ko04810 Regulation of actin cytoskeleton Rho guanine nucleotide exchange factor VAV3 T Signal transduction mechanisms ; IPR000219 [Dbl homology (DH) domain] ; IPR000980[SH2 domain] ; IPR001849[Pleckstrin homology domain] ; IPR002219[Protein kinase C-like, phorbol ester/diacylglycerol-binding domain] ; IPR011511[Variant SH3 domain] ; IPR022613[Calmodulin-regulated spectrin-associated protein, CH domain] -- -- Q5DU02 Ubiquitin carboxyl-terminal hydrolase 22 Usp22 360.7 347.3 438 382.6 389.9 378.3 0.995828988529718 0.960162804903604 -0.00603008209501994 Nonsignificant None 3 Molecular Function:zinc ion binding (GO:0008270),Biological Process:protein deubiquitination (GO:0016579),Molecular Function:thiol-dependent ubiquitinyl hydrolase activity (GO:0036459) ubiquitin carboxyl-terminal hydrolase 22/27/51 3.4.19.12 -- Ubiquitin-specific protease O Posttranslational modification, protein turnover, chaperones ; IPR001394 [Peptidase C19, ubiquitin carboxyl-terminal hydrolase] ; IPR001607[Zinc finger, UBP-type] -- -- Q3UPR7 Transmembrane protein 102 Tmem102 102.5 93.6 96.4 98.9 91.1 94.2 1.02920478536242 0.469981559519836 0.041530070115349 Nonsignificant None -- -- -- -- -- Mab-21-like cell fate specification proteins T Signal transduction mechanisms ; IPR024810 [Mab-21 domain] -- -- Q147V6 Stbd1 protein Stbd1 18.8 34.4 30.2 43.1 30 32.3 0.791271347248577 0.300132860536553 -0.337755578192551 Nonsignificant None 1 Molecular Function:starch binding (GO:2001070) starch-binding domain-containing protein 1 -- -- -- -- -- IPR002044 [Carbohydrate binding module family 20] -- -- D6RFQ2 Predicted gene 42957 Gm42957 201 183.8 183 181.7 189 193 1.00727337236119 0.849190124684155 0.01045528158318 Nonsignificant None 2 Cellular Component:integral component of peroxisomal membrane (GO:0005779),Biological Process:peroxisome fission (GO:0016559) peroxin-11B -- ko04146 Peroxisome Peroxisomal biogenesis protein (peroxin) U Intracellular trafficking, secretion, and vesicular transport ; IPR008733 [Peroxisomal biogenesis factor 11] -- -- Q9R1C0 Transcription initiation factor TFIID subunit 7 Taf7 27.4 25.4 35.4 30.5 30.4 29.5 0.975663716814159 0.833115274366065 -0.0355441168576671 Nonsignificant None 2 Cellular Component:transcription factor TFIID complex (GO:0005669),Biological Process:transcription initiation from RNA polymerase II promoter (GO:0006367) transcription initiation factor TFIID subunit 7 -- ko03022 Basal transcription factors Transcription initiation factor TFIID, subunit TAF7 K Transcription ; IPR006751 [TAFII55 protein, conserved region] -- -- Q9CQF8 Ribosomal protein 63, mitochondrial Mrpl57 137.3 135.6 153.3 184.4 182.9 169 0.794704456460936 0.00797472614104517 -0.331509660240896 Nonsignificant None 1 Cellular Component:mitochondrial ribosome (GO:0005761) -- -- -- -- -- -- IPR016576 [Ribosomal protein 63, mitochondrial] -- -- Q545R9 Cyclin-dependent kinases regulatory subunit Cks2 171 160.1 157.4 147.2 149.2 147.9 1.09948233175782 0.0684964745624718 0.136824420845744 Nonsignificant None 2 Biological Process:cell cycle (GO:0007049),Molecular Function:cyclin-dependent protein serine/threonine kinase regulator activity (GO:0016538) cyclin-dependent kinase regulatory subunit CKS1 -- ko05200 Pathways in cancer ko05222 Small cell lung cancer Cyclin-dependent protein kinase CDC28, regulatory subunit CKS1, and related proteins D Cell cycle control, cell division, chromosome partitioning ; IPR000789 [Cyclin-dependent kinase, regulatory subunit] -- -- Q3UFM5 Nucleolar MIF4G domain-containing protein 1 Nom1 31.1 32.1 26.4 27.3 21.2 25.7 1.20754716981132 0.112774276836502 0.272079545436801 Nonsignificant None 2 Molecular Function:RNA binding (GO:0003723),Molecular Function:protein binding (GO:0005515) nucleolar MIF4G domain-containing protein 1 -- -- Protein involved in high osmolarity signaling pathway T Signal transduction mechanisms ; IPR003890 [MIF4G-like, type 3] ; IPR003891[Initiation factor eIF-4 gamma, MA3] -- -- P12960 Contactin-1 Cntn1 65.9 57.5 64 83.6 65.7 72.9 0.843384338433843 0.115599534913056 -0.245737863729905 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) contactin 1 -- ko04514 Cell adhesion molecules (CAMs) Neural cell adhesion molecule L1 T Signal transduction mechanisms ; IPR003961 [Fibronectin type III] ; IPR013098[Immunoglobulin I-set] ; IPR013151[Immunoglobulin] -- -- P0DJF2 Protein PET117 homolog, mitochondrial Pet117 182.3 179.4 185.5 200.7 191.7 196.8 0.928716904276986 0.0112381200906422 -0.106689200149951 Nonsignificant None -- -- protein PET117 -- -- -- -- -- IPR031568 [Protein Pet117, mitochondrial] -- -- Q6DI81 Nuclear factor 1 Nfia 270.2 270.8 252.2 225.3 226.3 211 1.19710232417748 0.00517728894323876 0.259546474147833 Nonsignificant None 3 Cellular Component:intracellular (GO:0005622),Cellular Component:nucleus (GO:0005634),Biological Process:DNA replication (GO:0006260) nuclear factor I/A -- -- Nuclear factor I K Transcription ; IPR000647 [CTF transcription factor/nuclear factor 1] ; IPR003619[MAD homology 1, Dwarfin-type] ; IPR019548[CTF transcription factor/nuclear factor 1, N-terminal] -- CTF/NFI Q3UYR3 Uncharacterized protein (Fragment) Cbfb 52 66.9 54.7 54.7 51.3 67.9 0.998274870615296 0.98901834573604 -0.00249098486210795 Nonsignificant None 2 Molecular Function:transcription coactivator activity (GO:0003713),Cellular Component:nucleus (GO:0005634) -- -- -- Transcription factor CBF, beta subunit K Transcription ; IPR003417 [Core binding factor, beta subunit] -- CBF F7CWA0 GPN-loop GTPase 3 (Fragment) Gpn3 12.5 16 6.9 21.6 14.7 16.4 0.671726755218216 0.161847729331298 -0.574053601554217 Nonsignificant None -- -- uncharacterized protein -- -- Putative transcription factor FET5 K Transcription ; IPR004130 [GPN-loop GTPase] -- -- Q8K1C0 Protein angel homolog 2 Angel2 54.7 45.1 43.1 48 60.7 52.5 0.886476426799007 0.302716625478607 -0.173845827432151 Nonsignificant None -- -- protein angel -- -- Transcriptional effector CCR4-related protein K Transcription ; IPR005135 [Endonuclease/exonuclease/phosphatase] -- -- Q8VDP2 STING ER exit protein Steep1 34.8 25.6 23.1 20.6 28.5 25.9 1.11333333333333 0.541419506657604 0.154885601978171 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; -- -- -- Q9CWD8 Iron-sulfur protein NUBPL Nubpl 173 161.4 177.2 118.9 113.7 121.7 1.44397403330511 0.000574942358481908 0.530044798763323 Nonsignificant None -- -- ATP-binding protein involved in chromosome partitioning -- -- Predicted ATPase, nucleotide-binding D Cell cycle control, cell division, chromosome partitioning ; IPR033756 [Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35] -- -- Q8BHA0 INO80 complex subunit C Ino80c 145.9 146.7 183.3 129.4 113 120 1.31318984547461 0.0458333492530128 0.393075499114257 Nonsignificant None -- -- INO80 complex subunit C -- -- Uncharacterized conserved protein S Function unknown ; IPR013272 [Vps72/YL1, C-terminal] -- -- Q9JKF6 Nectin-1 Nectin1 54.8 53.6 55.2 55.4 52.6 55.2 1.00245098039216 0.902496228746354 0.00353169097025322 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) poliovirus receptor-related protein 1 -- ko04514 Cell adhesion molecules (CAMs) ko04520 Adherens junction ko05168 Herpes simplex infection -- -- -- IPR007110 [Immunoglobulin-like domain] ; IPR013106[Immunoglobulin V-set domain] ; IPR013162[CD80-like, immunoglobulin C2-set] -- -- F8WHJ1 FHF complex subunit HOOK-interacting protein 1B Fhip1b 63 53.9 53.3 52.7 49.1 58.3 1.0630855715178 0.460180009887717 0.0882577291697057 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019384 [Retinoic acid induced 16-like protein] -- -- Q6PFV2 Tex2 protein Tex2 21.7 15.1 12.9 12.2 17.7 16.8 1.06423982869379 0.766432941490656 0.0898233018526243 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein TEX2, contains PH domain R General function prediction only ; -- -- -- Q9CPR6 Keratin 88 Krt88 323 387.5 370.1 337.7 334.7 330.1 1.07790523690773 0.308647761595435 0.108230350397787 Nonsignificant None 2 Molecular Function:structural molecule activity (GO:0005198),Cellular Component:intermediate filament (GO:0005882) -- -- -- -- -- -- IPR001664 [Intermediate filament protein] -- -- Q61462 Cytochrome b-245 light chain Cyba 495 709.4 531.1 286.4 305.8 292.9 1.96079539035137 0.0495973558198482 0.971438997678757 Significant up 1 Molecular Function:heme binding (GO:0020037) cytochrome b-245, alpha polypeptide -- ko04145 Phagosome ko04380 Osteoclast differentiation ko04621 NOD-like receptor signaling pathway ko04670 Leukocyte transendothelial migration ko05140 Leishmaniasis ko05418 Fluid shear stress and atherosclerosis -- -- -- IPR007732 [Cytochrome b558 alpha-subunit] -- -- O35233 MAF4 (Fragment) Aff1 289.1 252.8 506.1 721.7 707.5 733.5 0.484579460859111 0.0413432792291147 -1.04519483814737 Significant down -- -- AF4/FMR2 family member 1 -- ko05202 Transcriptional misregulation in cancer -- -- -- IPR007797 [Transcription factor AF4/FMR2] -- -- Q9CZ69 CKLF-like MARVEL transmembrane domain-containing protein 6 Cmtm6 138.8 131.7 158.3 146.5 130.8 136.8 1.0354986718184 0.621550064306451 0.0503257030878941 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) -- -- -- Members of chemokine-like factor super family and related proteins V Defense mechanisms ; IPR008253 [Marvel domain] -- -- Q8C4D5 Uncharacterized protein (Fragment) Rftn1 33.9 26 37.6 35.2 31.8 35.2 0.954011741682974 0.686190754801398 -0.0679210723006485 Nonsignificant None -- -- -- -- -- -- -- -- IPR028169 [Raftlin family] -- -- Q8BIF7 CAF1C_H4-bd domain-containing protein Grwd1 281.1 255.5 264 274.8 267 255.1 1.00464299159242 0.902555909911899 0.00668291855566482 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) ribosome assembly protein RRB1 -- -- Ribosome Assembly protein R General function prediction only ; IPR001680 [WD40 repeat] ; IPR022052[Histone-binding protein RBBP4, N-terminal] -- -- H3BKF3 PAN2-PAN3 deadenylation complex subunit PAN3 Pan3 247 170.5 108.5 119.7 159.9 171.2 1.16681455190772 0.591172767459617 0.222575284007444 Nonsignificant None -- -- PAB-dependent poly(A)-specific ribonuclease subunit 3 -- ko03018 RNA degradation Poly(A) ribonuclease subunit A RNA processing and modification ; -- -- -- Q6DTY7 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 Pfkfb4 88.9 89.8 78.3 74.7 87.4 84.6 1.04175111471423 0.55499650571524 0.0590106437811173 Nonsignificant None 3 Molecular Function:6-phosphofructo-2-kinase activity (GO:0003873),Molecular Function:ATP binding (GO:0005524),Biological Process:fructose metabolic process (GO:0006000) -- -- ko00051 Fructose and mannose metabolism ko04152 AMPK signaling pathway Fructose-6-phosphate 2-kinase/fructose-2,6-biphosphatase G Carbohydrate transport and metabolism ; IPR013078 [Histidine phosphatase superfamily, clade-1] ; IPR013079[6-phosphofructo-2-kinase] -- -- E9PUY1 28S ribosomal protein S12, mitochondrial (Fragment) Mrps12 622.4 614.8 345.4 345.4 305.6 318.9 1.63171460975358 0.152120477102561 0.706388749038922 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) small subunit ribosomal protein S12 -- ko03010 Ribosome Mitochondrial/chloroplast ribosomal protein S12 J Translation, ribosomal structure and biogenesis ; IPR006032 [Ribosomal protein S12/S23] -- -- F8VQ45 Transmembrane channel-like protein Tmc4 49.1 54.8 44 45.4 49.9 51 1.01093643198906 0.888122701191064 0.0156922829605807 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) transmembrane channel-like protein -- -- -- -- -- IPR012496 [TMC] -- -- Q8BJU9 Peptide chain release factor 1-like, mitochondrial Mtrf1l 28.7 19.9 22.8 31.7 34.4 30 0.742976066597295 0.0463859144237858 -0.428612356744651 Nonsignificant None 3 Molecular Function:translation release factor activity (GO:0003747),Cellular Component:cytoplasm (GO:0005737),Biological Process:translational termination (GO:0006415) peptide chain release factor 1 -- -- Mitochondrial polypeptide chain release factor J Translation, ribosomal structure and biogenesis ; IPR000352 [Peptide chain release factor class I/class II] ; IPR005139[Peptide chain release factor] -- -- Q924W5 Structural maintenance of chromosomes protein 6 Smc6 38.9 48.6 45.9 55.6 52.1 54.8 0.820923076923077 0.0344758084872958 -0.284681051618594 Nonsignificant None -- -- -- -- -- DNA repair protein RAD18 (SMC family protein) L Replication, recombination and repair ; IPR003395 [RecF/RecN/SMC, N-terminal] -- -- Q8BLR5 PH and SEC7 domain-containing protein 4 Psd4 79.6 69 54.1 51.1 58.3 62.7 1.17780360255665 0.278036257364123 0.236098991426695 Nonsignificant None 2 Molecular Function:ARF guanyl-nucleotide exchange factor activity (GO:0005086),Biological Process:regulation of ARF protein signal transduction (GO:0032012) PH and SEC7 domain-containing protein -- ko04144 Endocytosis Guanine nucleotide exchange factor EFA6 U Intracellular trafficking, secretion, and vesicular transport ; IPR000904 [Sec7 domain] -- -- Q8CHH1 [Histone H3]-lysine(4) N-methyltransferase (Fragment) mKIAA0304 12.1 11.7 10.2 11 14.7 14 0.856423173803526 0.210035554067781 -0.223604261005256 Nonsignificant None 4 Molecular Function:DNA binding (GO:0003677),Molecular Function:protein binding (GO:0005515),Cellular Component:nucleus (GO:0005634),Molecular Function:zinc ion binding (GO:0008270) histone-lysine N-methyltransferase MLL4 2.1.1.43 ko00310 Lysine degradation Transcription factor TCF20 K Transcription ; IPR001214 [SET domain] ; IPR002857[Zinc finger, CXXC-type] ; IPR003888[FY-rich, N-terminal] ; IPR003889[FY-rich, C-terminal] ; IPR019787[Zinc finger, PHD-finger] -- -- Q8BGD8 Cytochrome c oxidase assembly factor 6 homolog Coa6 39.6 29.9 30.2 55 39.2 33.4 0.781347962382445 0.265892917320143 -0.355962919366673 Nonsignificant None 2 Molecular Function:cytochrome-c oxidase activity (GO:0004129),Cellular Component:mitochondrion (GO:0005739) cytochrome c oxidase assembly factor 6 -- -- Cytochrome c oxidase, subunit VIb/COX12 C Energy production and conversion ; IPR003213 [Cytochrome c oxidase, subunit VIb] -- -- Q9CS01 Uncharacterized protein (Fragment) Ifnar2 90.2 114.7 131.9 110.3 117 110.7 0.996449704142012 0.97559944999502 -0.00513110810315058 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) interferon receptor 2 -- ko04060 Cytokine-cytokine receptor interaction ko04151 PI3K-Akt signaling pathway ko04217 Necroptosis ko04380 Osteoclast differentiation ko04620 Toll-like receptor signaling pathway ko04621 NOD-like receptor signaling pathway ko04630 Jak-STAT signaling pathway ko04650 Natural killer cell mediated cytotoxicity ko05160 Hepatitis C ko05162 Measles ko05164 Influenza A ko05165 Human papillomavirus infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection ko05200 Pathways in cancer -- -- -- IPR003961 [Fibronectin type III] ; IPR015373[Interferon/interleukin receptor domain] -- -- Q9DAC7 Tetratricopeptide repeat protein 32 Ttc32 45 40.4 45.1 41.5 39.9 39.7 1.07762180016515 0.130667477387722 0.107850941762918 Nonsignificant None -- -- -- -- -- FOG: TPR repeat R General function prediction only ; IPR013105 [Tetratricopeptide repeat 2] -- -- Q9CVE7 COX assembly mitochondrial protein (Fragment) Cmc1 73.2 69.4 79.7 80.8 104.5 88.1 0.813094367227506 0.0892457047766284 -0.29850529457907 Nonsignificant None -- -- COX assembly mitochondrial protein 1 -- -- Uncharacterized conserved protein S Function unknown ; IPR013892 [Cytochrome c oxidase biogenesis protein Cmc1-like] -- -- A2AVQ6 Tetratricopeptide repeat domain 22 Ttc22 37.7 26.7 24.2 28.1 26.5 37.8 0.958874458874459 0.827495246341298 -0.0605861528610392 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR019734 [Tetratricopeptide repeat] -- -- Q00422 GA-binding protein alpha chain Gabpa 170.9 150.8 152.2 135.3 136 138.5 1.1564177647633 0.0778418902193811 0.209662676621354 Nonsignificant None 2 Cellular Component:nucleus (GO:0005634),Molecular Function:sequence-specific DNA binding (GO:0043565) GA-binding protein transcription factor, alpha -- -- Predicted transcription factor K Transcription ; IPR000418 [Ets domain] ; IPR003118[Pointed domain] ; IPR024668[GA-binding protein alpha subunit, N-terminal] -- ETS A2A559 Post-GPI attachment to proteins factor 3 Pgap3 33.6 29.4 36 34.2 46.7 40.5 0.815485996705107 0.142069341633994 -0.29426799128871 Nonsignificant None -- -- -- -- -- Predicted membrane protein S Function unknown ; IPR007217 [Per1-like] -- -- Q9QXG1 Mucin Muc4 (Fragment) Muc4 9.2 10.4 17.6 15.7 9.6 9.5 1.06896551724138 0.821910339003984 0.0962153152593033 Nonsignificant None 1 Biological Process:cell-matrix adhesion (GO:0007160) mucin-4 -- -- -- -- -- IPR001846 [von Willebrand factor, type D domain] ; IPR003886[NIDO domain] -- -- Q9R257 Heme-binding protein 1 Hebp1 464.6 472 455.3 297.8 315 323.8 1.48612000854153 0.000073620718521933 0.571550622428957 Nonsignificant None -- -- -- -- -- -- -- -- IPR006917 [SOUL haem-binding protein] -- -- S4R287 WASH complex subunit 3 Washc3 167.9 183.4 202.8 192.9 192.5 177 0.985241820768137 0.819751270174226 -0.0214502273689409 Nonsignificant None 1 Cellular Component:WASH complex (GO:0071203) WASH complex subunit CCDC53 -- ko04144 Endocytosis Predicted coiled-coil protein S Function unknown ; IPR019309 [WASH complex, subunit CCDC53] -- -- Q18PH8 CD48 Cd48 169 201.8 144.2 154.1 165.8 149 1.09831520580081 0.427201728611488 0.135292153237122 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) CD48 antigen -- ko04650 Natural killer cell mediated cytotoxicity -- -- -- IPR007110 [Immunoglobulin-like domain] ; IPR013106[Immunoglobulin V-set domain] -- -- Q3UYK2 Presenilin Psen1 66.3 65.3 54.1 61.9 72.7 70.6 0.904970760233918 0.273155933383404 -0.144056915671633 Nonsignificant None 3 Molecular Function:aspartic-type endopeptidase activity (GO:0004190),Cellular Component:integral component of membrane (GO:0016021),Biological Process:protein processing (GO:0016485) presenilin 1 3.4.23.- ko04310 Wnt signaling pathway ko04330 Notch signaling pathway ko04722 Neurotrophin signaling pathway ko05010 Alzheimer's disease ko05165 Human papillomavirus infection Presenilin T Signal transduction mechanisms ; IPR001108 [Peptidase A22A, presenilin] -- -- Q8BW00 Probable peptidyl-tRNA hydrolase Ptrh1 86.9 90.4 68.1 45.4 56.3 72.3 1.41034482758621 0.0847888851397837 0.496047942926814 Nonsignificant None 1 Molecular Function:aminoacyl-tRNA hydrolase activity (GO:0004045) peptidyl-tRNA hydrolase, PTH1 family 3.1.1.29 -- Peptidyl-tRNA hydrolase J Translation, ribosomal structure and biogenesis ; IPR001328 [Peptidyl-tRNA hydrolase] -- -- A0A1W2P7R0 Zinc transporter ZIP5 (Fragment) Slc39a5 26.3 34.3 69.5 46.2 46.2 47.1 0.932616487455197 0.835327621928388 -0.100644159998755 Nonsignificant None -- -- solute carrier family 39 (zinc transporter), member 5 -- -- Putative zinc transporter P Inorganic ion transport and metabolism ; -- -- -- P50427 Steryl-sulfatase Sts 13.5 11.2 8.2 11.4 12.7 11.6 0.92156862745098 0.58800223744792 -0.117836490293858 Nonsignificant None 2 Biological Process:metabolic process (GO:0008152),Molecular Function:sulfuric ester hydrolase activity (GO:0008484) steryl-sulfatase 3.1.6.2 ko00140 Steroid hormone biosynthesis Sulfatase R General function prediction only ; IPR000917 [Sulfatase, N-terminal] -- -- Q3UZP4 Small VCP/p97-interacting protein Svip 186.8 148.2 131.3 160.4 170.4 173.6 0.924464710547185 0.494134655711507 -0.113309845988325 Nonsignificant None -- -- small VCP/p97-interacting protein -- ko04141 Protein processing in endoplasmic reticulum -- -- -- IPR031632 [Small VCP/p97-interacting protein] -- -- Q8BHV6 Rhbdl2 protein Rhbdl2 143.4 125.1 153.9 196.6 171.7 195.3 0.749467707594038 0.0157124793755545 -0.416061776951183 Nonsignificant None -- -- rhomboid-related protein 1/2/3 3.4.21.105 -- Rhomboid family proteins T Signal transduction mechanisms ; -- -- -- Q8VDB2 Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase Alg12 44.6 36.6 34.1 25.4 23 30.7 1.45764854614412 0.0364039823908663 0.54364291317898 Nonsignificant None -- -- alpha-1,6-mannosyltransferase 2.4.1.260 ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways Protein involved in dolichol pathway for N-glycosylation (mannosyltransferase family) MU Cell wall/membrane/envelope biogenesis ; Intracellular trafficking, secretion, and vesicular transport ; IPR005599 [GPI mannosyltransferase] -- -- B9EKU4 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) Urb2 35.5 33.3 26.9 27.9 32.6 27.2 1.09122006841505 0.436360090574175 0.125942082041292 Nonsignificant None -- -- nucleolar pre-ribosomal-associated protein 2 -- -- -- -- -- IPR018849 [Nucleolar 27S pre-rRNA processing, Urb2/Npa2, C-terminal] -- -- Q3TXR4 Transcription factor JunB Junb 73.5 74.3 82.2 73.9 80.2 72 1.0172490048651 0.744456704240579 0.0246728690802086 Nonsignificant None 1 Molecular Function:sequence-specific DNA binding (GO:0043565) transcription factor jun-B -- ko04380 Osteoclast differentiation ko04668 TNF signaling pathway Transcriptional activator of the JUN family K Transcription ; IPR004827 [Basic-leucine zipper domain] ; IPR005643[Jun-like transcription factor] -- TF_bZIP Q8CCI9 Chloride channel protein Clcn7 136.1 176.8 229.1 273.7 246.6 225.8 0.726444176383863 0.087945261498042 -0.461076156696829 Nonsignificant None 4 Molecular Function:voltage-gated chloride channel activity (GO:0005247),Biological Process:chloride transport (GO:0006821),Cellular Component:membrane (GO:0016020),Biological Process:transmembrane transport (GO:0055085) chloride channel 7 -- -- Cl- channel CLC-7 and related proteins (CLC superfamily) P Inorganic ion transport and metabolism ; IPR000644 [CBS domain] ; IPR001807[Chloride channel, voltage gated] -- -- H3BLD0 ATP synthase mitochondrial F1 complex assembly factor 1 (Fragment) Atpaf1 67.1 65.9 79.4 93.4 92.2 77.1 0.808526836695851 0.0690244144416003 -0.306632434329478 Nonsignificant None -- -- ATP synthase mitochondrial F1 complex assembly factor 1 -- -- Mitochondrial F1-ATPase assembly protein O Posttranslational modification, protein turnover, chaperones ; -- -- -- Q5BL07 Peroxisome biogenesis factor 1 Pex1 27.6 20.5 21.2 21.8 23.4 19.8 1.06615384615385 0.595343305414233 0.092415634221397 Nonsignificant None 3 Molecular Function:ATP binding (GO:0005524),Cellular Component:peroxisome (GO:0005777),Biological Process:peroxisome organization (GO:0007031) peroxin-1 -- ko04146 Peroxisome AAA+-type ATPase O Posttranslational modification, protein turnover, chaperones ; IPR003959 [ATPase, AAA-type, core] ; IPR015342[Peroxisome biogenesis factor 1, N-terminal, psi beta-barrel fold] ; IPR015343[Peroxisome biogenesis factor 1, N-terminal, alpha/beta] -- -- E1U8D0 Protein SOGA1 Soga1 36 41.3 52.8 41.3 33.1 45.2 1.08779264214047 0.597279589928216 0.12140357251969 Nonsignificant None 2 Cellular Component:extracellular space (GO:0005615),Biological Process:regulation of autophagy (GO:0010506) -- -- -- -- -- -- IPR027881 [Protein SOGA] ; IPR027882[Domain of unknown function DUF4482] -- -- Q9CU65 Zinc finger MYM-type protein 2 Zmym2 31.3 25 29.1 51.1 44 58.9 0.554545454545455 0.00813811693444099 -0.850622375961773 Significant down 1 Molecular Function:zinc ion binding (GO:0008270) -- -- -- -- -- -- IPR010507 [Zinc finger, MYM-type] ; IPR021893[Protein of unknown function DUF3504] -- -- Q811L9 Dhps protein Dhps 7.8 6.1 0 7.7 10.5 6.1 0.858024691358025 0.563589495667921 -0.220908930161117 Nonsignificant None 1 Biological Process:peptidyl-lysine modification to peptidyl-hypusine (GO:0008612) deoxyhypusine synthase 2.5.1.46 -- Deoxyhypusine synthase O Posttranslational modification, protein turnover, chaperones ; IPR002773 [Deoxyhypusine synthase] -- -- B2RS43 DNA segment, Chr 17, human D6S53E D17H6S53E 234.2 245 329.2 290.8 301.8 277.8 0.928768382352941 0.539224283301764 -0.106609234870604 Nonsignificant None -- -- -- -- -- -- -- -- IPR029073 [Protein of unknown function DUF4661] -- -- F6TN13 RNA-binding region-containing protein 3 (Fragment) Rnpc3 37.6 27.9 28.6 22.6 32.9 31.6 1.08036739380023 0.63139632144134 0.111522004129672 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) U11/U12 small nuclear ribonucleoprotein 65 kDa protein -- -- Spliceosomal protein snRNP-U1A/U2B A RNA processing and modification ; IPR000504 [RNA recognition motif domain] -- -- Q6PEE2 CBP80/20-dependent translation initiation factor Ctif 39.6 35.3 38.7 49.9 42.7 54.2 0.773841961852861 0.0371833845898145 -0.369889133338531 Nonsignificant None 2 Molecular Function:RNA binding (GO:0003723),Molecular Function:protein binding (GO:0005515) -- -- -- MIF4G domain-containing protein J Translation, ribosomal structure and biogenesis ; IPR003890 [MIF4G-like, type 3] -- -- P07903 DNA excision repair protein ERCC-1 Ercc1 53.5 61.7 33.8 42.3 37.7 42.4 1.21732026143791 0.351870693436946 0.283708772656872 Nonsignificant None 4 Molecular Function:damaged DNA binding (GO:0003684),Molecular Function:endonuclease activity (GO:0004519),Cellular Component:nucleus (GO:0005634),Biological Process:DNA repair (GO:0006281) DNA excision repair protein ERCC-1 -- ko01524 Platinum drug resistance ko03420 Nucleotide excision repair ko03460 Fanconi anemia pathway Structure-specific endonuclease ERCC1-XPF, ERCC1 component L Replication, recombination and repair ; IPR004579 [ERCC1/RAD10/SWI10 family] -- -- Q9JLJ0 Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog Litaf 605.2 614.8 543.2 713.2 656.9 665.3 0.866267072811241 0.0333387365653247 -0.207116214024361 Nonsignificant None -- -- lipopolysaccharide-induced tumor necrosis factor-alpha factor -- ko04142 Lysosome -- -- -- IPR006629 [LPS-induced tumour necrosis factor alpha factor] -- zf-LITAF-like Q80Y84 Lysine-specific demethylase 5B Kdm5b 18.6 14.8 14.8 14 10.3 14.9 1.22959183673469 0.188296143918185 0.298179492114753 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Molecular Function:protein binding (GO:0005515),Biological Process:oxidation-reduction process (GO:0055114) histone demethylase JARID1 1.14.11.- -- DNA-binding protein jumonji/RBP2/SMCY, contains JmjC domain R General function prediction only ; IPR001606 [ARID DNA-binding domain] ; IPR003347[JmjC domain] ; IPR003349[JmjN domain] ; IPR004198[Zinc finger, C5HC2-type] ; IPR013637[Lysine-specific demethylase-like domain] ; IPR019787[Zinc finger, PHD-finger] -- ARID O35730 E3 ubiquitin-protein ligase RING1 Ring1 130.4 158.4 170.1 213.3 186.4 198.7 0.766878342245989 0.0300769015731807 -0.382930368475364 Nonsignificant None -- -- E3 ubiquitin-protein ligase RNF1/2 2.3.2.27 -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR032443 [RAWUL domain] -- -- Q08EE0 2310022M17Rik protein Bod1 33.5 45.1 45.1 62.3 58.9 45.6 0.741606714628297 0.0880304248128692 -0.431273788468294 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q8BVK9 Sp110 nuclear body protein Sp110 34.6 38.4 28 31.8 30.7 33 1.05759162303665 0.587217280083991 0.0807826547160459 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634) -- -- -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR000770 [SAND domain] ; IPR004865[HSR domain] -- SAND Q5HZH2 18S rRNA aminocarboxypropyltransferase Tsr3 19.9 13.5 12.1 15.7 19.3 16.1 0.890410958904109 0.521142562446978 -0.167456745851563 Nonsignificant None -- -- pre-rRNA-processing protein TSR3 -- -- Uncharacterized conserved protein S Function unknown ; IPR007177 [Ribosome biogenesis protein, C-terminal] ; IPR007209[RNase L inhibitor RLI, possible metal-binding domain] -- -- Q9JHH6 Carboxypeptidase B2 Cpb2 44.8 48.2 46.4 21.2 27.8 29 1.78717948717949 0.00144129239036436 0.837684532118812 Significant up 4 Molecular Function:carboxypeptidase activity (GO:0004180),Molecular Function:metallocarboxypeptidase activity (GO:0004181),Biological Process:proteolysis (GO:0006508),Molecular Function:zinc ion binding (GO:0008270) carboxypeptidase B2 3.4.17.20 ko04610 Complement and coagulation cascades ko04972 Pancreatic secretion ko04974 Protein digestion and absorption Zinc carboxypeptidase S Function unknown ; IPR000834 [Peptidase M14, carboxypeptidase A] ; IPR003146[Carboxypeptidase, activation peptide] -- -- Q62392 Pleckstrin homology-like domain family A member 1 Phlda1 132.3 130.8 165.1 159.8 130.3 146.1 0.981659789087575 0.858883843521162 -0.026704974255241 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q7TNE3 Sperm-associated antigen 7 Spag7 503.2 564.7 407.7 430.9 415.3 343.9 1.23989580707504 0.146685110969116 0.310218890828382 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- -- -- -- IPR001374 [R3H domain] -- -- A0A286YCZ4 Phenylalanine--tRNA ligase (Fragment) Fars2 106.5 121.3 146.2 159 157.7 163.7 0.778517901748543 0.0887311873311447 -0.361197880930635 Nonsignificant None 5 Molecular Function:tRNA binding (GO:0000049),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Cellular Component:cytoplasm (GO:0005737),Biological Process:tRNA aminoacylation (GO:0043039) phenylalanyl-tRNA synthetase alpha chain 6.1.1.20 ko00970 Aminoacyl-tRNA biosynthesis Phenylalanyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR002319 [Phenylalanyl-tRNA synthetase] -- -- Q8R3L8 Cyclin-dependent kinase 8 Cdk8 70.1 92.4 93.4 117.4 120.5 86.7 0.788354898336414 0.157754781838641 -0.343082852508525 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) -- -- -- Cyclin C-dependent kinase CDK8 K Transcription ; IPR000719 [Protein kinase domain] -- -- E9QLQ7 Ras-related protein Rab Rab29 43.4 33.9 46.4 31.7 30.9 32.9 1.29528795811518 0.126879441526868 0.373272862053259 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-related protein Rab-7L1 -- -- GTP-binding protein-like, RAS superfamily T Signal transduction mechanisms ; IPR001806 [Small GTPase superfamily] -- -- Q8K4Q8 Collectin-12 Colec12 127.2 149 236 228 242.3 196.9 0.767685851318945 0.222813386255529 -0.381412035847195 Nonsignificant None -- -- collectin sub-family member 12 -- ko04145 Phagosome -- -- -- IPR001304 [C-type lectin-like] ; IPR008160[Collagen triple helix repeat] -- -- Q80TN4 DnaJ homolog subfamily C member 16 Dnajc16 74.1 56.6 56 60.9 60.9 57.7 1.04011142061281 0.710993210822197 0.0567380835157881 Nonsignificant None 1 Biological Process:cell redox homeostasis (GO:0045454) DnaJ homolog subfamily C member 16 -- -- -- -- -- IPR001623 [DnaJ domain] ; IPR013766[Thioredoxin domain] -- -- Q4KML9 Tyrosine-protein phosphatase non-receptor type Ptpn21 92.8 105.2 26.9 214.5 264.2 111 0.381380362896388 0.076600806616305 -1.3906975330441 Nonsignificant None 2 Molecular Function:protein tyrosine phosphatase activity (GO:0004725),Biological Process:protein dephosphorylation (GO:0006470) tyrosine-protein phosphatase non-receptor type 14/21 3.1.3.48 -- Protein tyrosine phosphatase PTPMEG, contains FERM domain T Signal transduction mechanisms ; IPR000242 [PTP type protein phosphatase] ; IPR018979[FERM, N-terminal] ; IPR018980[FERM, C-terminal PH-like domain] ; IPR019748[FERM central domain] -- -- Q80WX3 Smurf2 protein (Fragment) Smurf2 6 7.1 0 5.9 12.3 5.9 0.815352697095436 0.631163496551983 -0.294503833971355 Nonsignificant None 1 Molecular Function:ubiquitin-protein transferase activity (GO:0004842) E3 ubiquitin ligase SMURF1/2 2.3.2.26 ko04120 Ubiquitin mediated proteolysis ko04144 Endocytosis ko04340 Hedgehog signaling pathway ko04350 TGF-beta signaling pathway Ubiquitin protein ligase RSP5/NEDD4 O Posttranslational modification, protein turnover, chaperones ; IPR000569 [HECT domain] -- -- E9Q748 Antileukoproteinase Slpi 600.8 559.7 413.2 543.6 506.2 436.8 1.05859007130365 0.678069170226168 0.0821440278666781 Nonsignificant None 2 Cellular Component:extracellular region (GO:0005576),Molecular Function:peptidase inhibitor activity (GO:0030414) -- -- -- -- -- -- IPR008197 [WAP-type 'four-disulfide core' domain] -- -- Q9DCU2 Plasmolipin Pllp 23.1 17 19 20.6 25.2 23 0.859011627906977 0.221247722760731 -0.219250434524566 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) -- -- -- Members of chemokine-like factor super family and related proteins V Defense mechanisms ; IPR008253 [Marvel domain] -- -- Q8BXE4 Leucine-rich repeat-containing protein 14 Lrrc14 29.3 24.7 24.2 29.7 22.1 26.6 0.997448979591837 0.981747538268908 -0.0036850468078559 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR001611 [Leucine-rich repeat] -- -- Q8VCG3 WD repeat-containing protein 74 Wdr74 101.9 106.3 132.2 110.5 100.5 123.7 1.01703017627726 0.877803544309498 0.0243624859994332 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) ribosome biogenesis protein NSA1 -- -- Uncharacterized conserved protein S Function unknown ; IPR001680 [WD40 repeat] -- -- P70260 Oct11 POU-box protein (119 AA) (Fragment) Pou2f3 43.2 40.6 46.4 42.9 47.3 42.5 0.981160512434062 0.732745710054439 -0.0274389222045579 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) POU domain transcription factor, class 2 -- -- Transcription factor OCT-1, contains POU and HOX domains K Transcription ; IPR000327 [POU-specific domain] ; IPR001356[Homeobox domain] -- Pou Q69ZV3 MKIAA0930 protein (Fragment) mKIAA0930 64.1 63.9 50.8 41.5 53.9 62.9 1.12950094756791 0.41974373300134 0.175685481046137 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019141 [Protein of unknown function DUF2045] -- -- Q3TBU7 Arf-GAP domain and FG repeat-containing protein 2 (Fragment) Agfg2 59.1 79.7 73.6 84.1 99.2 87.8 0.783474732571007 0.0619873499574903 -0.352041347033558 Nonsignificant None 1 Molecular Function:GTPase activator activity (GO:0005096) -- -- -- Predicted GTPase-activating protein T Signal transduction mechanisms ; IPR001164 [Arf GTPase activating protein] -- -- B2RY18 FERM and PDZ domain containing 1 Frmpd1 404.3 421 415.4 372.5 360.1 359.9 1.13565217391304 0.00155081633410514 0.183521035714693 Nonsignificant None -- -- -- -- -- FERM domain protein FRM-8 R General function prediction only ; IPR019748 [FERM central domain] -- -- Q8VCQ3 Nuclear receptor-binding factor 2 Nrbf2 52.4 59.8 49.2 71.4 58.7 61.7 0.841501564129301 0.110248971847236 -0.248962141740351 Nonsignificant None 1 Biological Process:autophagy (GO:0006914) nuclear receptor-binding factor 2 -- ko04140 Autophagy - animal -- -- -- IPR015056 [Nuclear receptor-binding factor 2] ; IPR033393[Nuclear receptor-binding factor 2, MIT domain] -- -- Q8VCS3 Glycosaminoglycan xylosylkinase Fam20b 63.8 77 56 71.4 68.3 66.8 0.953026634382567 0.633609734820627 -0.0694115609675679 Nonsignificant None -- -- glycosaminoglycan xylosylkinase 2.7.1.- -- Uncharacterized conserved protein S Function unknown ; IPR009581 [FAM20, C-terminal] -- -- Q80UY7 SCY1-like protein 2 (Fragment) Scyl2 42.6 40.3 42.6 53.9 46 50.9 0.832228116710875 0.0254623421887356 -0.26494906443053 Nonsignificant None -- -- SCY1-like protein 2 -- -- Protein kinase T Signal transduction mechanisms ; -- -- -- Q3UM18 Large subunit GTPase 1 homolog Lsg1 219.8 207.2 222 211.5 195.8 219.8 1.03492265986286 0.434512899710033 0.0495229586411718 Nonsignificant None 1 Molecular Function:GTP binding (GO:0005525) large subunit GTPase 1 3.6.1.- ko03008 Ribosome biogenesis in eukaryotes Predicted GTP-binding protein MMR1 R General function prediction only ; IPR006073 [GTP binding domain] -- -- Q8BGB2 Tetratricopeptide repeat protein 7A Ttc7a 47.7 48.8 46.4 55.6 63.5 65.9 0.772432432432432 0.0116714896238404 -0.372519354307858 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) tetratricopeptide repeat protein 7 -- -- Predicted calmodulin-binding protein T Signal transduction mechanisms ; IPR019734 [Tetratricopeptide repeat] -- -- Q3URN2 Alpha-1,3-glucosyltransferase Alg8 31.2 30.4 36 22.4 17.5 26.3 1.47432024169184 0.0275578163238505 0.560049930755669 Nonsignificant None 1 Cellular Component:endoplasmic reticulum membrane (GO:0005789) alpha-1,3-glucosyltransferase 2.4.1.265 ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways Glucosyltransferase - Alg8p K Transcription ; IPR004856 [Glycosyl transferase, ALG6/ALG8] -- -- Q9CPS8 Small membrane A-kinase anchor protein 74.2 73.1 78.9 86.5 100.5 99.5 0.789528795811518 0.0142995900432517 -0.340936209654447 Nonsignificant None 1 Molecular Function:protein kinase A regulatory subunit binding (GO:0034237) -- -- -- -- -- -- IPR027969 [Small membrane A-kinase anchor protein] -- -- Q3TXC6 Tetraspanin Tspan3 266 235.7 279.7 354.1 347.6 367.9 0.730553477935677 0.00256382653265053 -0.45293820990968 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) tetraspanin-3 -- -- Tetraspanin family integral membrane protein R General function prediction only ; IPR018499 [Tetraspanin/Peripherin] -- -- D6RH67 Transmembrane protein 62 Tmem62 110.9 124.1 133 113.4 111.5 126.6 1.04694167852063 0.528830895341602 0.0661810769844775 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) -- -- -- -- -- -- IPR004843 [Calcineurin-like phosphoesterase domain, ApaH type] -- -- Q9EQF6 Dihydropyrimidinase-related protein 5 Dpysl5 180.4 173.4 211.8 271.3 249.3 254.9 0.729335912314636 0.0066418530540297 -0.455344661114054 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) dihydropyrimidinase-like 5 -- ko04360 Axon guidance Dihydroorotase and related enzymes F Nucleotide transport and metabolism ; IPR006680 [Amidohydrolase-related] -- -- D3Z1F7 Putative monooxygenase p33MONOX 4833439L19Rik 37.6 37.1 32.1 33.8 42.1 37.2 0.944297082228117 0.520004709469982 -0.0826872823022665 Nonsignificant None -- -- -- -- -- -- -- -- IPR026759 [Putative monooxygenase p33MONOX] -- -- Q9CPR7 Suppressor of IKBKE 1 Sike1 154.1 154.6 155.8 164.9 165.2 173 0.923275690717551 0.00885793336120528 -0.115166593015487 Nonsignificant None -- -- suppressor of IKK-epsilon -- ko04622 RIG-I-like receptor signaling pathway -- -- -- IPR008555 [Suppressor of IKBKE 1] -- -- Q8BGY7 Protein FAM210A Fam210a 308.2 305.4 311 341.7 317.6 312.8 0.951136714329801 0.156371810676068 -0.0722753690384026 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR009688 [Domain of unknown function DUF1279] -- -- E9PXF8 Myotubularin-related protein 13 Sbf2 54.4 72.4 73.9 72.5 68.6 71 0.946251768033946 0.582767375621951 -0.0797040041679379 Nonsignificant None -- -- myotubularin-related protein 5/13 -- -- Predicted dual-specificity phosphatase R General function prediction only ; IPR001194 [DENN domain] ; IPR001849[Pleckstrin homology domain] ; IPR004182[GRAM domain] ; IPR005113[uDENN domain] ; IPR010569[Myotubularin-like phosphatase domain] ; IPR022096[SBF1/SBF2 domain] -- -- Q8C4C7 Uncharacterized protein Ophn1 12.9 16.8 15.9 17.7 18.8 20.7 0.797202797202797 0.0580469563773792 -0.326981322613648 Nonsignificant None 1 Biological Process:signal transduction (GO:0007165) oligophrenin-1 -- -- Oligophrenin-1 and related Rho GTPase-activating proteins T Signal transduction mechanisms ; IPR000198 [Rho GTPase-activating protein domain] ; IPR001849[Pleckstrin homology domain] -- -- Q8BH73 Glutaminyl-peptide cyclotransferase-like protein Qpctl 224.8 204.6 175.6 194 171.9 209 1.05235693164029 0.604794501565286 0.0736241116358155 Nonsignificant None -- -- glutaminyl-peptide cyclotransferase 2.3.2.5 -- Glutaminyl cyclase O Posttranslational modification, protein turnover, chaperones ; IPR007484 [Peptidase M28] -- -- D3Z553 Protein Churchill Churc1 47.6 49.4 42 47.2 50.8 45.4 0.96931659693166 0.620308550512546 -0.0449601410910348 Nonsignificant None 2 Biological Process:multicellular organism development (GO:0007275),Molecular Function:zinc ion binding (GO:0008270) -- -- -- -- -- -- IPR009508 [Transcription activator, Churchill] -- -- G3X9T2 Zinc finger protein 619 Zfp619 188.8 174.6 146.7 187.7 192.8 188 0.897273526824978 0.254856492955808 -0.156380248382668 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Cellular Component:intracellular (GO:0005622),Molecular Function:metal ion binding (GO:0046872) KRAB domain-containing zinc finger protein -- -- FOG: Zn-finger R General function prediction only ; IPR001909 [Krueppel-associated box] ; IPR007087[Zinc finger, C2H2] -- zf-C2H2 Q6ZQ01 MKIAA1017 protein (Fragment) mKIAA1017 24.4 23.1 24.7 22.4 22.8 32.2 0.9328165374677 0.644011149984579 -0.100334729257239 Nonsignificant None -- -- Hermansky-Pudlak syndrome 5 protein -- -- -- -- -- -- -- -- Q6PIJ4 Nuclear factor related to kappa-B-binding protein Nfrkb 65.2 74 86.3 113 118.5 106.8 0.666568134791605 0.0057725029349939 -0.585175743651245 Significant down -- -- nuclear factor related to kappa-B-binding protein -- -- R-kappa-B and related transcription factors K Transcription ; IPR025220 [NFRKB winged helix-like domain] -- -- Q9CR02 Translation machinery-associated protein 16 Tma16 51.2 63.2 59.1 60.6 77.5 72.2 0.825011887779363 0.115011045546076 -0.277513187266156 Nonsignificant None -- -- translation machinery-associated protein 16 -- -- -- -- -- IPR021346 [Translation machinery-associated protein 16] -- -- D9J2V6 Pre-B-cell leukemia transcription factor 1 Pbx1 57.7 61 62.6 73.1 67.7 52.5 0.937920331091567 0.561961432407298 -0.0924627124670778 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634) pre-B-cell leukemia transcription factor 1 -- ko05202 Transcriptional misregulation in cancer Transcription factor PBX and related HOX domain proteins K Transcription ; IPR001356 [Homeobox domain] ; IPR005542[PBX] -- Homeobox Q9JHU2 Palmdelphin Palmd 52.3 52.6 50 59.4 55.4 52.6 0.925328554360813 0.123019507571578 -0.111962383760775 Nonsignificant None 2 Biological Process:regulation of cell shape (GO:0008360),Cellular Component:membrane (GO:0016020) A-kinase anchor protein 2 -- -- -- -- -- IPR004965 [Paralemmin] -- -- Q9CPU2 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial Ndufb2 66.1 62.2 68.4 100.9 95.9 90.6 0.684411969380654 0.000967414064254253 -0.547063104178806 Nonsignificant None -- -- NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 2 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04723 Retrograde endocannabinoid signaling ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease -- -- -- -- -- -- Q811P8 Rho GTPase-activating protein 32 Arhgap32 79.9 84.4 92.9 98.1 109.7 102.7 0.828341384863124 0.0251006341798843 -0.271702625779896 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Biological Process:signal transduction (GO:0007165),Molecular Function:phosphatidylinositol binding (GO:0035091) Rho GTPase-activating protein 32 -- -- Predicted Rho GTPase-activating protein CdGAPr T Signal transduction mechanisms ; IPR000198 [Rho GTPase-activating protein domain] ; IPR001452[SH3 domain] ; IPR001683[Phox homologous domain] -- -- Q61790 Lymphocyte activation gene 3 protein Lag3 211.1 198.4 254.4 311.4 284.3 286.7 0.752379873073436 0.0186796642470035 -0.410466839069215 Nonsignificant None -- -- lymphocyte-activation gene 3 protein -- -- -- -- -- IPR013151 [Immunoglobulin] -- -- Q54AC6 Cox17p COX17 162.3 176.5 238.2 208.8 251.5 242.2 0.82135231316726 0.191711112213834 -0.283926906462806 Nonsignificant None 4 Molecular Function:copper ion binding (GO:0005507),Cellular Component:mitochondrial intermembrane space (GO:0005758),Biological Process:copper ion transport (GO:0006825),Molecular Function:copper chaperone activity (GO:0016531) cytochrome c oxidase assembly protein subunit 17 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways Cytochrome c oxidase assembly protein/Cu2+ chaperone COX17 O Posttranslational modification, protein turnover, chaperones ; IPR007745 [Cytochrome c oxidase copper chaperone] -- -- Q3UNT5 Uncharacterized protein (Fragment) 185.9 206.6 35.2 84.9 88.1 177.5 1.22025677603424 0.699200829382221 0.287184762978348 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- A6H6S8 BCL2-associated athanogene 4 Bag4 39.2 53.3 55 51.5 61.6 60.8 0.848188614146061 0.214173199448421 -0.237542978170021 Nonsignificant None 1 Molecular Function:chaperone binding (GO:0051087) BCL2-associated athanogene 4 -- ko04668 TNF signaling pathway BCL2-associated athanogene-like proteins and related BAG family chaperone regulators T Signal transduction mechanisms ; IPR003103 [BAG domain] -- -- A2AER4 UDP-galactose translocator Slc35a2 147.7 138.3 152.5 173.2 186.6 159 0.845219737856592 0.0408957825978892 -0.242601636919604 Nonsignificant None 4 Cellular Component:Golgi membrane (GO:0000139),Molecular Function:sugar:proton symporter activity (GO:0005351),Biological Process:carbohydrate transport (GO:0008643),Cellular Component:integral component of membrane (GO:0016021) solute carrier family 35 (UDP-sugar transporter), member A1/2/3 -- -- Predicted UDP-galactose transporter G Carbohydrate transport and metabolism ; IPR007271 [Nucleotide-sugar transporter] -- -- H3BJ38 Myomegalin Pde4dip 447.3 440 448.4 373.1 364.5 361.7 1.21504593832439 0.0000534099416124025 0.281010860119046 Nonsignificant None -- -- myomegalin -- -- -- -- -- -- -- -- Q03145 Ephrin type-A receptor 2 Epha2 64.9 77.5 32.1 32.6 37.9 34.1 1.66826003824092 0.226022864334235 0.738344184850073 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein binding (GO:0005515),Biological Process:protein phosphorylation (GO:0006468) Eph receptor A2 2.7.10.1 ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04151 PI3K-Akt signaling pathway ko04360 Axon guidance Tyrosine kinase, EPH (ephrin) receptor family T Signal transduction mechanisms ; IPR001090 [Ephrin receptor ligand binding domain] ; IPR001245[Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR001660[Sterile alpha motif domain] ; IPR003961[Fibronectin type III] ; IPR027936[Ephrin receptor, transmembrane domain] -- -- D3Z286 Transmembrane protein with metallophosphoesterase domain Tmppe 129.1 128.7 163.8 168.9 163.6 146.6 0.87998330202463 0.226944463168878 -0.184451946495174 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) -- -- -- -- -- -- IPR004843 [Calcineurin-like phosphoesterase domain, ApaH type] -- -- A0A087WQS9 Putative ATP-dependent RNA helicase TDRD12 (Fragment) Tdrd12 193.7 242.6 69 321.8 354.9 196.8 0.578477389811105 0.157260877874538 -0.789667523186169 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase TDRD12 3.6.4.13 -- -- -- -- IPR002999 [Tudor domain] ; IPR011545[DEAD/DEAH box helicase domain] -- -- A0A087WRN5 Predicted gene 13889 Gm13889 47.7 45.7 42.9 52.7 57.8 55.6 0.82059000602047 0.00807607859041909 -0.285266511157167 Nonsignificant None -- -- -- -- -- -- -- -- IPR031521 [Domain of unknown function DUF4695] -- -- Q8R1F0 Leydig cell tumor 10 kDa protein homolog D8Ertd738e 184.1 180.9 186.3 191.5 197.6 196.8 0.94094555384878 0.00957775812705492 -0.0878168485168365 Nonsignificant None -- -- -- -- -- -- -- -- IPR019034 [Uncharacterised protein family UPF0390] -- -- Q9EPX7 Leukemia associated gene protein Mllt1 59.1 52.4 36.3 61.7 47.5 56.4 0.892512077294686 0.496094370547802 -0.164056403353174 Nonsignificant None -- -- YEATS domain-containing protein 1/3 -- ko05202 Transcriptional misregulation in cancer Transcription initiation factor IIF, auxiliary subunit K Transcription ; IPR005033 [YEATS] -- -- Q9CWB7 Glutaredoxin-like protein C5orf63 homolog 16 9.3 18.4 10 9.2 11.1 1.44224422442244 0.183154476477331 0.528315486027647 Nonsignificant None -- -- -- -- -- -- -- -- IPR008554 [Glutaredoxin-like] -- -- Q9JL47 ATP-binding cassette protein (Fragment) Abcf1 20 23.4 33.5 32.2 34.8 31.8 0.77834008097166 0.154269576939576 -0.361527443622851 Nonsignificant None -- -- ATP-binding cassette, subfamily F, member 1 -- -- eIF2-interacting protein ABC50 (ABC superfamily) J Translation, ribosomal structure and biogenesis ; -- -- -- Q7TMX5 Protein SHQ1 homolog Shq1 47.1 48 34.1 32.2 38.3 36.8 1.20410065237651 0.206839110426242 0.267955993937403 Nonsignificant None -- -- protein SHQ1 -- -- Uncharacterized conserved protein S Function unknown ; IPR007009 [SHQ1 protein] -- -- Q8BGZ2 Protein FAM168A Fam168a 39.3 28.8 31.6 34.4 39.2 36.4 0.906363636363636 0.373981887052617 -0.141838114013826 Nonsignificant None -- -- -- -- -- -- -- -- IPR029247 [FAM168A/MANI] -- -- Q9CUG5 Ankyrin repeat domain-containing protein 53 (Fragment) Ankrd53 184.2 176 204.7 161.4 208.7 195.1 0.999469214437367 0.995439957060065 -0.000765964998555176 Nonsignificant None -- -- ankyrin repeat domain-containing protein 53 -- -- Ankyrin M Cell wall/membrane/envelope biogenesis ; IPR020683 [Ankyrin repeat-containing domain] -- -- Q91VY9 Cytoplasmic 60S subunit biogenesis factor ZNF622 Znf622 193 185.2 184.4 154.9 176.3 158.9 1.14792899408284 0.027407719992674 0.199033405904943 Nonsignificant None -- -- pre-60S factor REI1 -- -- C2H2-type Zn-finger protein R General function prediction only ; IPR015880 [Zinc finger, C2H2-like] -- -- Q8BPW8 Uncharacterized protein Gm14762 211.4 227.2 252.2 291.5 276.4 271.1 0.823361144219309 0.0208657717212077 -0.280402727798261 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q3U4G3 Xyloside xylosyltransferase 1 Xxylt1 144.9 136.8 130 154.5 146.3 180.2 0.855925155925156 0.105500858302715 -0.224443445336135 Nonsignificant None -- -- -- -- -- Predicted glycosyltransferase G Carbohydrate transport and metabolism ; IPR002495 [Glycosyl transferase, family 8] -- -- Q3TDX8 Cytochrome b5 reductase 4 Cyb5r4 136.7 134.5 106.1 102.6 115.2 105.5 1.1670275286112 0.16362625659522 0.222838592684024 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) cytochrome-b5 reductase 1.6.2.2 ko00520 Amino sugar and nucleotide sugar metabolism NADH-cytochrome b-5 reductase HC Coenzyme transport and metabolism ; Energy production and conversion ; IPR001199 [Cytochrome b5-like heme/steroid binding domain] ; IPR001433[Oxidoreductase FAD/NAD(P)-binding] ; IPR007052[CS domain] ; IPR008333[Oxidoreductase, FAD-binding domain] -- -- Q4VAH7 HEPACAM family member 2 Hepacam2 41.9 39 40.7 44.2 49.5 54.1 0.822733423545332 0.0428459045287852 -0.281503040702565 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- D3Z271 Methyltransferase-like 27 (Fragment) Mettl27 68.3 56 65.1 61.7 55.4 64.4 1.0435261707989 0.593625446978815 0.061466782585272 Nonsignificant None -- -- -- -- -- Predicted protein carboxyl methylase R General function prediction only ; -- -- -- Q91WE2 PSME3-interacting protein Psme3ip1 184.3 180.4 177.5 158.5 190.3 166.7 1.05179437439379 0.412250522578448 0.0728526855822411 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019331 [FAM192A/Fyv6, N-terminal] -- -- B0LAE3 Pleiotrophin (Fragment) Ptn 291.3 259.6 192.6 268.2 245.1 266.7 0.953205128205128 0.706146837692297 -0.0691413816971919 Nonsignificant None 1 Molecular Function:growth factor activity (GO:0008083) pleiotrophin -- -- -- -- -- IPR020090 [Pleiotrophin/Midkine, C-terminal domain] -- -- A0A1B0GT29 Chloride channel protein Clcn4 221.6 215.3 219.5 200.5 212.5 224.9 1.02900141087945 0.444858409740833 0.0412449603342993 Nonsignificant None 4 Molecular Function:voltage-gated chloride channel activity (GO:0005247),Biological Process:chloride transport (GO:0006821),Cellular Component:membrane (GO:0016020),Biological Process:transmembrane transport (GO:0055085) chloride channel 3/4/5 -- -- Cl- channel CLC-3 and related proteins (CLC superfamily) P Inorganic ion transport and metabolism ; IPR000644 [CBS domain] ; IPR001807[Chloride channel, voltage gated] -- -- Q9R0A5 Serine/threonine-protein kinase Nek3 Nek3 47.5 53 59.3 65.7 67.2 62.2 0.819067145053819 0.0339977548864189 -0.287946369681049 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) NIMA (never in mitosis gene a)-related kinase 3 2.7.11.1 -- Serine/threonine protein kinase R General function prediction only ; IPR000719 [Protein kinase domain] -- -- Q9JMA3 Transcription factor GATA-6 (Fragment) GATA-6 57 51.5 67.9 65.1 56.3 58.2 0.982182628062361 0.855957690161821 -0.0259367891836262 Nonsignificant None 4 Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634),Molecular Function:zinc ion binding (GO:0008270),Molecular Function:sequence-specific DNA binding (GO:0043565) GATA-binding protein 6 -- -- GATA-4/5/6 transcription factors K Transcription ; IPR000679 [Zinc finger, GATA-type] ; IPR008013[GATA-type transcription activator, N-terminal] -- zf-GATA Q8R2P1 Kelch-like protein 25 Klhl25 10.3 7.4 12.9 14 18.6 9.9 0.72 0.252998607373588 -0.473931188332412 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) kelch-like protein 25/37 (ectoderm-neural cortex protein) -- -- Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes TR Signal transduction mechanisms ; General function prediction only ; IPR000210 [BTB/POZ domain] ; IPR006652[Kelch repeat type 1] ; IPR011705[BTB/Kelch-associated] -- ZBTB O35969 Guanidinoacetate N-methyltransferase Gamt 107.5 93.6 94.5 91.2 107.8 90 1.02283737024221 0.777886523297588 0.03257677675811 Nonsignificant None -- -- guanidinoacetate N-methyltransferase 2.1.1.2 ko00260 Glycine, serine and threonine metabolism ko00330 Arginine and proline metabolism ko01100 Metabolic pathways Guanidinoacetate methyltransferase and related proteins E Amino acid transport and metabolism ; -- -- -- E9PYH6 Histone-lysine N-methyltransferase SETD1A Setd1a 37.3 36.6 27.5 26.3 36.6 31.3 1.07643312101911 0.609450897194144 0.106258687390557 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:protein binding (GO:0005515) histone-lysine N-methyltransferase SETD1 2.1.1.43 ko00310 Lysine degradation -- -- -- IPR000504 [RNA recognition motif domain] ; IPR001214[SET domain] ; IPR024657[COMPASS complex Set1 subunit, N-SET domain] -- -- A0A286T4B5 Cytochrome c oxidase subunit 1 COX1 336.1 301.8 272 253.2 227.1 309.2 1.15250158328056 0.258408896136852 0.204768732597728 Nonsignificant None 7 Molecular Function:cytochrome-c oxidase activity (GO:0004129),Molecular Function:iron ion binding (GO:0005506),Molecular Function:electron carrier activity (GO:0009055),Biological Process:aerobic respiration (GO:0009060),Cellular Component:integral component of membrane (GO:0016021),Molecular Function:heme binding (GO:0020037),Biological Process:oxidation-reduction process (GO:0055114) cytochrome c oxidase subunit 1 1.9.3.1 ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04260 Cardiac muscle contraction ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease Cytochrome c oxidase, subunit I C Energy production and conversion ; IPR000883 [Cytochrome c oxidase subunit I] -- -- Q99NG0 Helicase ARIP4 Rad54l2 231.6 284.8 116.8 335.4 393.6 224.5 0.664079706345045 0.20253751633999 -0.590571683062937 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) RAD54-like protein 2 3.6.4.12 -- Predicted DNA helicase, DEAD-box superfamily R General function prediction only ; IPR000330 [SNF2-related, N-terminal domain] ; IPR001650[Helicase, C-terminal] -- -- E0CZ42 Fer-1-like 6 (C. elegans) Fer1l6 52.1 50.1 55.8 60.6 69 50.5 0.87729039422543 0.258869410294182 -0.188873622841811 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:integral component of membrane (GO:0016021) fer-1-like protein 6 -- -- Membrane-associated protein FER-1 and related ferlins, contain multiple C2 domains M Cell wall/membrane/envelope biogenesis ; IPR000008 [C2 domain] ; IPR012561[Ferlin B-domain] ; IPR012968[FerIin domain] ; IPR032362[Ferlin, C-terminal domain] -- -- Q8CD14 ATP-dependent RNA helicase DDX54 Ddx54 18.2 17.7 12.9 13.8 18.8 21.1 0.908752327746741 0.582961520606548 -0.138040940422527 Nonsignificant None 5 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:RNA binding (GO:0003723),Molecular Function:ATP-dependent RNA helicase activity (GO:0004004),Molecular Function:ATP binding (GO:0005524),Cellular Component:nucleus (GO:0005634) ATP-dependent RNA helicase DDX54/DBP10 3.6.4.13 -- ATP-dependent RNA helicase A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR011545[DEAD/DEAH box helicase domain] ; IPR012541[DBP10, C-terminal] -- -- P63147 Ubiquitin-conjugating enzyme E2 B Ube2b 73.2 69.1 69.2 61.7 64.2 68.6 1.08740359897172 0.0798410428125228 0.120887508133758 Nonsignificant None -- -- ubiquitin-conjugating enzyme E2 B 2.3.2.23 ko04120 Ubiquitin mediated proteolysis Ubiquitin-protein ligase O Posttranslational modification, protein turnover, chaperones ; IPR000608 [Ubiquitin-conjugating enzyme E2] -- -- Q8CHT1 Ephexin-1 Ngef 20.4 24.8 30.8 33.8 34.6 34 0.7421875 0.0990948210592646 -0.430144391669052 Nonsignificant None 3 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Molecular Function:protein binding (GO:0005515),Biological Process:regulation of Rho protein signal transduction (GO:0035023) neuronal guanine nucleotide exchange factor -- ko04360 Axon guidance Putative guanine nucleotide exchange factor TIM T Signal transduction mechanisms ; IPR000219 [Dbl homology (DH) domain] ; IPR001452[SH3 domain] -- -- Q9D7B7 Probable glutathione peroxidase 8 Gpx8 257.5 264.7 288.8 264.2 260.7 253 1.04255045635686 0.332894676972068 0.0601172075301845 Nonsignificant None 3 Molecular Function:glutathione peroxidase activity (GO:0004602),Biological Process:response to oxidative stress (GO:0006979),Biological Process:oxidation-reduction process (GO:0055114) glutathione peroxidase 1.11.1.9 ko00480 Glutathione metabolism ko00590 Arachidonic acid metabolism ko04918 Thyroid hormone synthesis Glutathione peroxidase O Posttranslational modification, protein turnover, chaperones ; IPR000889 [Glutathione peroxidase] -- -- Q8BZQ9 Tryptophan--tRNA ligase Wars2 113.3 122.6 130.8 174 135.8 149.7 0.79804134929271 0.0650559514021878 -0.325464595464731 Nonsignificant None 4 Molecular Function:nucleotide binding (GO:0000166),Molecular Function:aminoacyl-tRNA ligase activity (GO:0004812),Molecular Function:ATP binding (GO:0005524),Biological Process:tRNA aminoacylation for protein translation (GO:0006418) tryptophanyl-tRNA synthetase 6.1.1.2 ko00970 Aminoacyl-tRNA biosynthesis Mitochondrial tryptophanyl-tRNA synthetase J Translation, ribosomal structure and biogenesis ; IPR002305 [Aminoacyl-tRNA synthetase, class Ic] -- -- F8WGD2 Ras and Rab interactor 2 Rin2 76 61.6 364.9 381.6 382.9 306.4 0.46923148753385 0.136713473921637 -1.09162826697549 Nonsignificant None 1 Biological Process:signal transduction (GO:0007165) -- -- -- RAS effector RIN1 (contains VPS domain) U Intracellular trafficking, secretion, and vesicular transport ; IPR000159 [Ras-associating (RA) domain] ; IPR003123[VPS9 domain] -- -- Q6RI63 Constitutive coactivator of peroxisome proliferator-activated receptor gamma Fam120b 16.8 17.2 14 18.5 19.9 16.1 0.880733944954128 0.221648342644743 -0.18322182405577 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q8VCM5 Mitochondrial ubiquitin ligase activator of NFKB 1 Mul1 33.3 29.9 29.1 39.5 41.8 42 0.748580697485807 0.00242722641045471 -0.417770246757065 Nonsignificant None 3 Molecular Function:ubiquitin-protein transferase activity (GO:0004842),Biological Process:organelle organization (GO:0006996),Biological Process:protein ubiquitination (GO:0016567) E3 ubiquitin-protein ligase MUL1 2.3.2.27 -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR022170 [E3 Ubiquitin ligase, GIDE-type] -- -- Q149L6 DnaJ homolog subfamily B member 14 Dnajb14 15.8 14.3 15.9 12.4 10.1 17.1 1.16161616161616 0.372005953814923 0.216133430864766 Nonsignificant None -- -- DnaJ homolog subfamily B member 14 -- -- Molecular chaperone (DnaJ superfamily) O Posttranslational modification, protein turnover, chaperones ; IPR001623 [DnaJ domain] ; IPR015399[Domain of unknown function DUF1977, DnaJ-like] -- -- Q6P7W5 tRNA-splicing endonuclease subunit Sen2 Tsen2 232.8 254.9 226.4 200.1 222.1 214.4 1.12174049638706 0.0745371379725153 0.165738961261109 Nonsignificant None 1 Molecular Function:tRNA-intron endonuclease activity (GO:0000213) tRNA-splicing endonuclease subunit Sen2 3.1.27.9 -- tRNA splicing endonuclease SEN2 J Translation, ribosomal structure and biogenesis ; IPR006677 [tRNA intron endonuclease, catalytic domain-like] ; IPR006678[tRNA intron endonuclease, N-terminal] -- -- Q8CBV1 Uncharacterized protein Etv6 326.3 357.6 501.7 361.3 393.2 354.5 1.06907123534716 0.668343861160962 0.0963579872567613 Nonsignificant None 2 Cellular Component:nucleus (GO:0005634),Molecular Function:sequence-specific DNA binding (GO:0043565) ETS translocation variant 6/7 -- ko05202 Transcriptional misregulation in cancer Transcription factor NERF and related proteins, contain ETS domain K Transcription ; IPR000418 [Ets domain] ; IPR003118[Pointed domain] -- ETS D3Z667 Dynein axonemal heavy chain 2 Dnah2 16.4 15.8 19 23 28.7 15.8 0.758518518518518 0.23194003741367 -0.398743691938193 Nonsignificant None 5 Molecular Function:microtubule motor activity (GO:0003777),Molecular Function:ATP binding (GO:0005524),Biological Process:microtubule-based movement (GO:0007018),Molecular Function:ATPase activity (GO:0016887),Cellular Component:dynein complex (GO:0030286) dynein heavy chain, axonemal -- ko05016 Huntington's disease Dyneins, heavy chain Z Cytoskeleton ; IPR004273 [Dynein heavy chain domain] ; IPR011704[ATPase, dynein-related, AAA domain] ; IPR013594[Dynein heavy chain, domain-1] ; IPR013602[Dynein heavy chain, domain-2] ; IPR024317[Dynein heavy chain, P-loop containing D4 domain] ; IPR024743[Dynein heavy chain, coiled coil stalk] -- -- E9Q8W9 Ubiquitin carboxyl-terminal hydrolase Usp3 143.5 135.4 133 156.3 148.3 142.8 0.920652659812249 0.0788938652449354 -0.119271130190862 Nonsignificant None 3 Molecular Function:zinc ion binding (GO:0008270),Biological Process:protein deubiquitination (GO:0016579),Molecular Function:thiol-dependent ubiquitinyl hydrolase activity (GO:0036459) ubiquitin carboxyl-terminal hydrolase 3 3.4.19.12 -- Ubiquitin-specific protease O Posttranslational modification, protein turnover, chaperones ; IPR001394 [Peptidase C19, ubiquitin carboxyl-terminal hydrolase] ; IPR001607[Zinc finger, UBP-type] -- -- Q9D061 Acyl-CoA-binding domain-containing protein 6 Acbd6 48.8 48.9 43.1 43.3 49.5 39.8 1.06184012066365 0.469308615553786 0.0865665585247095 Nonsignificant None 1 Molecular Function:fatty-acyl-CoA binding (GO:0000062) -- -- -- Acyl-CoA-binding protein I Lipid transport and metabolism ; IPR000582 [Acyl-CoA-binding protein, ACBP] ; IPR020683[Ankyrin repeat-containing domain] -- -- A0A2I3BRJ4 RIKEN cDNA 6030458C11 gene 6030458C11Rik 56.1 47.1 48.4 46.8 50.6 53.6 1.00397350993377 0.956288017485875 0.00572120395865035 Nonsignificant None -- -- -- -- -- -- -- -- IPR024131 [Uncharacterised protein family UPF0489] -- -- Q80VC8 PRKCA-binding protein Pick1 134.3 110.9 118.4 121.1 118.5 129 0.986435160065111 0.83687349342975 -0.0197038714366059 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:protein domain specific binding (GO:0019904) -- -- -- Protein kinase C, alpha binding protein T Signal transduction mechanisms ; IPR001478 [PDZ domain] ; IPR010504[Arfaptin homology (AH) domain] -- -- Q3TQY7 UMA domain-containing protein Ubap1 45.3 41.5 43.4 37.5 46.2 39.7 1.05510534846029 0.468441162210989 0.0773870540162176 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q8C4B4 Protein unc-119 homolog B Unc119b 165.3 175.1 131.1 142.1 137.6 131.7 1.14608653378707 0.216727526686754 0.196715977037525 Nonsignificant None -- -- -- -- -- Photoreceptor synaptic vesicle protein HRG4/UNC-119 UT Intracellular trafficking, secretion, and vesicular transport ; Signal transduction mechanisms ; IPR008015 [GMP phosphodiesterase, delta subunit] -- -- Q9D289 Trafficking protein particle complex subunit 6B Trappc6b 68.4 64.5 56.3 59.2 74.3 76.5 0.900952380952381 0.346364910011578 -0.15047723921409 Nonsignificant None -- -- trafficking protein particle complex subunit 6 -- -- Transport protein particle (TRAPP) complex subunit U Intracellular trafficking, secretion, and vesicular transport ; IPR007194 [Transport protein particle (TRAPP) component] -- -- Q7TQK1 Integrator complex subunit 7 Ints7 23.2 16.6 19.5 25.2 13.6 16.7 1.06846846846847 0.765005518383215 0.0955443333085353 Nonsignificant None -- -- integrator complex subunit 7 -- -- Uncharacterized conserved protein S Function unknown ; -- -- -- P15119 Mast cell protease 2 Mcpt2 268.4 270.1 221.2 257.9 258.7 238.6 1.00595868644068 0.935143874874662 0.00857105654398778 Nonsignificant None 2 Molecular Function:serine-type endopeptidase activity (GO:0004252),Biological Process:proteolysis (GO:0006508) mast cell peptidase 2 3.4.21.- -- Trypsin E Amino acid transport and metabolism ; IPR001254 [Serine proteases, trypsin domain] -- -- P60603 Reactive oxygen species modulator 1 Romo1 514.3 471 461.3 401.2 396.5 417.5 1.19042132982225 0.01160137748837 0.251472281821599 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR018450 [Romo1/Mgr2] -- -- Q922E6 FAST kinase domain-containing protein 2, mitochondrial Fastkd2 27.5 22.7 20.1 26.7 27.2 24.2 0.900128040973111 0.332017708918007 -0.151797859069444 Nonsignificant None 1 Molecular Function:protein kinase activity (GO:0004672) FAST kinase domain-containing protein 2 -- -- -- -- -- IPR010622 [FAST kinase leucine-rich] ; IPR013584[RAP domain] -- -- E9PUV9 Caspase recruitment domain-containing protein 10 Card10 19.1 20.3 19.2 27.1 15.1 21.6 0.918495297805643 0.667552423619779 -0.122655759342621 Nonsignificant None 1 Biological Process:regulation of apoptotic process (GO:0042981) caspase recruitment domain-containing protein 10 -- ko04064 NF-kappa B signaling pathway -- -- -- IPR001315 [CARD domain] -- -- A9C491 Cullin 7 Cul7 198.5 159.2 116.2 126.2 120 143.9 1.21481671366316 0.323383920416975 0.280738662608039 Nonsignificant None 2 Biological Process:ubiquitin-dependent protein catabolic process (GO:0006511),Molecular Function:ubiquitin protein ligase binding (GO:0031625) cullin 7 -- ko04120 Ubiquitin mediated proteolysis -- -- -- IPR001373 [Cullin, N-terminal] ; IPR004939[APC10/DOC domain] ; IPR021097[CPH domain] -- -- D3YVM8 Biogenesis of lysosome-related organelles complex 1 subunit 1 Bloc1s1 42.5 41.2 35.7 42.9 38.8 48 0.920585967617579 0.367180773783508 -0.119375642986894 Nonsignificant None 1 Cellular Component:BLOC-1 complex (GO:0031083) biogenesis of lysosome-related organelles complex 1 subunit 1 -- -- General control of amino-acid synthesis 5-like 1 K Transcription ; IPR009395 [Biogenesis of lysosome-related organelles complex 1 subunit 1] -- -- Q9CXD6 Mitochondrial calcium uniporter regulator 1 Mcur1 228.3 221.4 199.2 255.4 244.5 297.9 0.813361744798195 0.055105505145795 -0.298030957404028 Nonsignificant None -- -- mitochondrial calcium uniporter regulator 1 -- -- Uncharacterized membrane protein S Function unknown ; IPR024461 [Coiled-coil domain-containing protein 90-like] -- -- Q3UVK9 Fibronectin type-III domain-containing protein Ifngr2 5.3 5.9 11.5 6.5 7.2 8.7 1.01339285714286 0.963928364748703 0.0191935652333107 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) interferon gamma receptor 2 -- ko04060 Cytokine-cytokine receptor interaction ko04066 HIF-1 signaling pathway ko04217 Necroptosis ko04380 Osteoclast differentiation ko04630 Jak-STAT signaling pathway ko04650 Natural killer cell mediated cytotoxicity ko04658 Th1 and Th2 cell differentiation ko04659 Th17 cell differentiation ko05132 Salmonella infection ko05140 Leishmaniasis ko05142 Chagas disease (American trypanosomiasis) ko05145 Toxoplasmosis ko05152 Tuberculosis ko05162 Measles ko05164 Influenza A ko05168 Herpes simplex infection ko05200 Pathways in cancer ko05321 Inflammatory bowel disease (IBD) -- -- -- IPR003961 [Fibronectin type III] ; IPR015373[Interferon/interleukin receptor domain] -- -- Q8VIQ4 Podocalyxin Podxl 191 185.5 223.4 322.8 297.9 243.5 0.69416801666281 0.028337869113156 -0.52664319941963 Nonsignificant None -- -- podocalyxin-like -- -- -- -- -- IPR013836 [CD34/Podocalyxin] -- -- Q8CCC2 DUF4682 domain-containing protein (Fragment) D630039A03Rik 152.1 169.8 232.7 215.7 246.6 228.4 0.802953525409005 0.156540321332645 -0.316611607272159 Nonsignificant None -- -- -- -- -- -- -- -- IPR032738 [TBC1 domain family member 30, C-terminal] -- -- Q99KW9 T-cell immunomodulatory protein Itfg1 129.1 133.3 156.3 177.9 173 161.2 0.817613747314978 0.0336328052098547 -0.290508641008592 Nonsignificant None -- -- integrin alpha FG-GAP repeat containing protein 1 -- -- Predicted membrane protein S Function unknown ; -- -- -- A0A2R8W6G1 E3 ubiquitin-protein ligase RBX1 Rbx1 273.9 300 246.5 220 245.1 256.5 1.13691796008869 0.155304928606145 0.185128153224471 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) RING-box protein 1 -- ko03420 Nucleotide excision repair ko04066 HIF-1 signaling pathway ko04110 Cell cycle ko04114 Oocyte meiosis ko04120 Ubiquitin mediated proteolysis ko04141 Protein processing in endoplasmic reticulum ko04310 Wnt signaling pathway ko04350 TGF-beta signaling pathway ko04710 Circadian rhythm ko05200 Pathways in cancer ko05211 Renal cell carcinoma SCF ubiquitin ligase, Rbx1 component O Posttranslational modification, protein turnover, chaperones ; IPR024766 [Zinc finger, RING-H2-type] -- -- Q9DD06 Retinoic acid receptor responder protein 2 Rarres2 55.4 57.7 42 58.8 66.4 55.2 0.859756097560976 0.226389365735744 -0.21800065221929 Nonsignificant None -- -- retinoic acid receptor responder protein 2 -- -- -- -- -- -- -- -- Q80W37 Snurportin-1 Snupn 147 143.4 151.4 149 168.7 153.6 0.937407171652875 0.198325496200357 -0.0932522626600776 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) snurportin-1 -- ko03013 RNA transport m3G-cap-specific nuclear import receptor (Snurportin1) A RNA processing and modification ; IPR024721 [Snurportin-1, N-terminal] -- -- Q3UH06 Ras-responsive element-binding protein 1 Rreb1 24.8 23.7 23.6 25.2 30 30 0.846244131455399 0.056765134530709 -0.240854170985016 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) ras-responsive element-binding protein 1 -- FOG: Zn-finger R General function prediction only ; IPR007087 [Zinc finger, C2H2] -- zf-C2H2 Q9R207 Nibrin Nbn 35.7 60.6 50 48.8 70.8 54 0.842741935483871 0.405847371805705 -0.246837178305992 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) nibrin -- ko03440 Homologous recombination ko04218 Cellular senescence -- -- -- IPR000253 [Forkhead-associated (FHA) domain] ; IPR013908[DNA repair Nbs1, C-terminal] ; IPR032429[Nibrin, second BRCT domain] -- -- Q9CWS2 Uncharacterized protein Atf1 191.9 159.8 174.7 158.1 165.8 147.7 1.11620016963528 0.161594601284474 0.158595770755479 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:sequence-specific DNA binding (GO:0043565) activating transcription factor 1 -- ko04925 Aldosterone synthesis and secretion ko05166 HTLV-I infection ko05202 Transcriptional misregulation in cancer cAMP response element binding protein and related transcription factors K Transcription ; IPR003102 [Coactivator CBP, pKID] ; IPR004827[Basic-leucine zipper domain] -- TF_bZIP A2AE21 Zinc finger protein 300 Zfp300 881.9 719.7 289.6 197 269.4 191.5 2.87460100319197 0.142913045214325 1.52336172278278 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Cellular Component:intracellular (GO:0005622),Molecular Function:metal ion binding (GO:0046872) KRAB domain-containing zinc finger protein -- -- FOG: Zn-finger R General function prediction only ; IPR001909 [Krueppel-associated box] ; IPR007087[Zinc finger, C2H2] -- zf-C2H2 P70424 Receptor tyrosine-protein kinase erbB-2 Erbb2 26.1 30 55.8 51.3 57.6 60.1 0.662130177514793 0.120660379865658 -0.594813210193153 Nonsignificant None 6 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:transmembrane receptor protein tyrosine kinase activity (GO:0004714),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468),Biological Process:transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169),Cellular Component:membrane (GO:0016020) receptor tyrosine-protein kinase erbB-2 2.7.10.1 ko01521 EGFR tyrosine kinase inhibitor resistance ko01522 Endocrine resistance ko01524 Platinum drug resistance ko04012 ErbB signaling pathway ko04020 Calcium signaling pathway ko04066 HIF-1 signaling pathway ko04510 Focal adhesion ko04520 Adherens junction ko04530 Tight junction ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05206 MicroRNAs in cancer ko05212 Pancreatic cancer ko05213 Endometrial cancer ko05215 Prostate cancer ko05219 Bladder cancer ko05223 Non-small cell lung cancer ko05224 Breast cancer ko05226 Gastric cancer ko05230 Central carbon metabolism in cancer Epidermal growth factor receptor EGFR and related tyrosine kinases T Signal transduction mechanisms ; IPR000494 [Receptor L-domain] ; IPR001245[Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR006211[Furin-like cysteine-rich domain] ; IPR032778[Growth factor receptor domain 4] -- -- Q924Z5 Translocating chain-associated membrane protein 2 Tram2 290.5 307.2 306.1 297.6 315 252.3 1.0449762978379 0.54147411208033 0.0634702194549406 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) -- -- -- Protein transporter of the TRAM (translocating chain-associating membrane) superfamily U Intracellular trafficking, secretion, and vesicular transport ; IPR006634 [TRAM/LAG1/CLN8 homology domain] ; IPR013599[TRAM1-like protein] -- -- Q91VX2 Ubiquitin-associated protein 2 Ubap2 153.5 162.1 170.1 129.9 137.6 118.9 1.25698757763975 0.0102463217858222 0.329970392187949 Nonsignificant None -- -- -- -- -- -- -- -- IPR022166 [Protein of unknown function DUF3697, ubiquitin-associated protein 2] -- -- E9QN37 Macrophage-expressed gene 1 protein Mpeg1 50.3 41.9 54.1 47.2 49.3 47.4 1.01667824878388 0.837933619031329 0.023863177398189 Nonsignificant None -- -- -- -- -- -- -- -- IPR020864 [Membrane attack complex component/perforin (MACPF) domain] -- -- D3YYC3 Histone-lysine N-methyltransferase SETDB1 Setdb1 155.4 142.3 111.6 90.6 88.9 104.1 1.44322990126939 0.0388925301720923 0.529301134203569 Nonsignificant None 6 Molecular Function:DNA binding (GO:0003677),Molecular Function:protein binding (GO:0005515),Cellular Component:nucleus (GO:0005634),Molecular Function:zinc ion binding (GO:0008270),Molecular Function:histone-lysine N-methyltransferase activity (GO:0018024),Biological Process:histone lysine methylation (GO:0034968) histone-lysine N-methyltransferase SETDB1 2.1.1.43 ko00310 Lysine degradation ko04550 Signaling pathways regulating pluripotency of stem cells Predicted histone methyl transferase B Chromatin structure and dynamics ; IPR001214 [SET domain] ; IPR001739[Methyl-CpG DNA binding] ; IPR007728[Pre-SET domain] -- MBD Q9WU81 Glucose-6-phosphate exchanger SLC37A2 Slc37a2 47.8 39.9 33.8 57.8 74.3 66.2 0.612708018154312 0.0149342472655723 -0.706728363735704 Significant down 2 Cellular Component:integral component of membrane (GO:0016021),Biological Process:transmembrane transport (GO:0055085) MFS transporter, OPA family, solute carrier family 37 (glycerol-3-phosphate transporter), member 1/2 -- -- Permease of the major facilitator superfamily G Carbohydrate transport and metabolism ; IPR011701 [Major facilitator superfamily] -- -- D3Z7S8 Transcription initiation factor IIA gamma chain (Fragment) Gtf2a2 245.8 252.9 265.4 239.5 263.7 254.2 1.00884605228413 0.817743314302643 0.0127060391109314 Nonsignificant None 2 Cellular Component:transcription factor TFIIA complex (GO:0005672),Biological Process:transcription initiation from RNA polymerase II promoter (GO:0006367) transcription initiation factor TFIIA small subunit -- ko03022 Basal transcription factors ko05203 Viral carcinogenesis Transcription initiation factor IIA, gamma subunit K Transcription ; IPR015871 [Transcription initiation factor IIA, gamma subunit, C-terminal] ; IPR015872[Transcription initiation factor IIA, gamma subunit, N-terminal] -- -- Q8BGF6 ELMO domain-containing protein 2 Elmod2 33.3 33.7 38.2 30.5 27.2 33.8 1.14972677595628 0.138097269004304 0.201291056120898 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR006816 [ELMO domain] -- -- Q0P6I6 Coiled-coil domain containing 91 Ccdc91 91.7 78.1 82.7 72.3 79.7 86.6 1.058256496228 0.465135001723948 0.0816893448312916 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- P38585 Tubulin--tyrosine ligase Ttl 37.5 35.4 38.2 41.3 36.6 41.8 0.928153717627402 0.197674654855315 -0.10756433555441 Nonsignificant None 1 Biological Process:cellular protein modification process (GO:0006464) tubulin---tyrosine ligase 6.3.2.25 -- Predicted tubulin-tyrosine ligase O Posttranslational modification, protein turnover, chaperones ; IPR004344 [Tubulin-tyrosine ligase/Tubulin polyglutamylase] -- -- Q99PQ2 E3 ubiquitin-protein ligase TRIM11 Trim11 42.8 39.2 39.3 30.5 34.2 33 1.24155578300921 0.00810695894404753 0.312149083152125 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Cellular Component:intracellular (GO:0005622),Molecular Function:zinc ion binding (GO:0008270) tripartite motif-containing protein 11 2.3.2.27 -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR000315 [B-box-type zinc finger] ; IPR003877[SPRY domain] ; IPR006574[SPRY-associated] -- -- Z4YLX5 DnaJ homolog subfamily C member 25 (Fragment) Dnajc25 96.1 97.7 124.7 115.2 111.9 110.7 0.942865600947306 0.560948960973924 -0.0848759556577231 Nonsignificant None -- -- DnaJ homolog subfamily C member 25 -- -- Molecular chaperone (DnaJ superfamily) O Posttranslational modification, protein turnover, chaperones ; -- -- -- Q5U5M8 Biogenesis of lysosome-related organelles complex 1 subunit 3 Bloc1s3 190 174.1 187.9 174.4 178.5 189.6 1.01751152073733 0.663137081362172 0.0250451294463273 Nonsignificant None -- -- biogenesis of lysosome-related organelles complex 1 subunit 3 -- -- -- -- -- IPR017245 [BLOC-1 complex, subunit 3] -- -- Q543K2 Superoxide dismutase copper chaperone Ccs 289.9 284.7 323.1 294.1 286.5 289.1 1.03219500977349 0.48797880650952 0.045715560930833 Nonsignificant None 4 Biological Process:superoxide metabolic process (GO:0006801),Biological Process:metal ion transport (GO:0030001),Molecular Function:metal ion binding (GO:0046872),Biological Process:oxidation-reduction process (GO:0055114) copper chaperone for superoxide dismutase -- ko05014 Amyotrophic lateral sclerosis (ALS) Copper chaperone for superoxide dismutase P Inorganic ion transport and metabolism ; IPR001424 [Superoxide dismutase, copper/zinc binding domain] ; IPR006121[Heavy metal-associated domain, HMA] -- -- Q3T981 Uncharacterized protein Cox10 150.4 140.2 189.3 123.1 129.7 126.4 1.26555907172996 0.151954590044842 0.339774848817935 Nonsignificant None -- -- heme o synthase 2.5.1.141 ko00190 Oxidative phosphorylation ko00860 Porphyrin and chlorophyll metabolism ko01100 Metabolic pathways Heme A farnesyltransferase H Coenzyme transport and metabolism ; -- -- -- O88819 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 Fut9 21.8 17.4 22.8 22.8 28.7 27.2 0.787801778907243 0.0834360398692317 -0.344095420233249 Nonsignificant None 3 Biological Process:protein glycosylation (GO:0006486),Molecular Function:fucosyltransferase activity (GO:0008417),Cellular Component:membrane (GO:0016020) 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 2.4.1.152 ko00515 Mannose type O-glycan biosynthesis ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series ko00603 Glycosphingolipid biosynthesis - globo and isoglobo series ko01100 Metabolic pathways Fucosyltransferase GE Carbohydrate transport and metabolism ; Amino acid transport and metabolism ; IPR001503 [Glycosyl transferase family 10] ; IPR031481[Fucosyltransferase, N-terminal] -- -- Q62036 Centrosomal protein of 131 kDa Cep131 24.3 23.1 27.2 35.6 20.8 28.6 0.877647058823529 0.478957486460891 -0.188287210769826 Nonsignificant None -- -- 5-azacytidine-induced protein 1 -- -- -- -- -- -- -- -- A0A0R4J0B0 Prominin-1 Prom1 34.9 33.6 42.3 39.7 28 35.6 1.07260406582769 0.597808271079766 0.101117627184128 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) prominin 1 -- ko05202 Transcriptional misregulation in cancer Polytopic membrane protein Prominin R General function prediction only ; IPR008795 [Prominin] -- -- Q8R5G7 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 Arap3 18.6 19.7 30.5 21.2 19.3 24.1 1.06501547987616 0.746702469144429 0.0908744000081728 Nonsignificant None 3 Molecular Function:GTPase activator activity (GO:0005096),Molecular Function:protein binding (GO:0005515),Biological Process:signal transduction (GO:0007165) Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 -- ko04015 Rap1 signaling pathway ko04024 cAMP signaling pathway ko04144 Endocytosis Rho- and Arf-GTPase activating protein ARAP3 TZ Signal transduction mechanisms ; Cytoskeleton ; IPR000159 [Ras-associating (RA) domain] ; IPR000198[Rho GTPase-activating protein domain] ; IPR001164[Arf GTPase activating protein] ; IPR001660[Sterile alpha motif domain] ; IPR001849[Pleckstrin homology domain] -- -- A1A5B6 TBC1 domain family member 25 Tbc1d25 154.9 97.1 113.7 98.1 108.6 107.5 1.16390833863781 0.382201815751003 0.218977446047172 Nonsignificant None -- -- -- -- -- Ypt/Rab-specific GTPase-activating protein GYP7 and related proteins T Signal transduction mechanisms ; IPR000195 [Rab-GTPase-TBC domain] -- -- A0A286YDK4 Centrosomal protein 192 (Fragment) Cep192 51.5 46.2 62.6 52.9 50.4 54.2 1.01777777777778 0.859873026116723 0.025422596879907 Nonsignificant None -- -- centrosomal protein CEP192 -- -- -- -- -- -- -- -- B1ATD4 Phosphatidylinositol-3-phosphate phosphatase (Fragment) Mtmr3 74 85.3 74.5 92.8 86.5 88.5 0.873039581777446 0.0516216651605778 -0.195881030792654 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) -- -- ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system ko04140 Autophagy - animal Phosphatidylinositol 3-phosphate 3-phosphatase myotubularin MTM1 IU Lipid transport and metabolism ; Intracellular trafficking, secretion, and vesicular transport ; IPR000306 [FYVE zinc finger] ; IPR010569[Myotubularin-like phosphatase domain] -- -- Q9DB30 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform Phkg2 5.3 6.2 0 2.4 7.9 9.4 0.875634517766497 0.787163941295076 -0.191599267790845 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) phosphorylase kinase gamma subunit 2.7.11.19 ko04020 Calcium signaling pathway ko04910 Insulin signaling pathway ko04922 Glucagon signaling pathway Phosphorylase kinase gamma subunit G Carbohydrate transport and metabolism ; IPR000719 [Protein kinase domain] -- -- Q3UYI4 Cocaine- and amphetamine-regulated transcript protein Cartpt 41.1 25.3 43.7 21 24.1 24.3 1.5864553314121 0.0811331717000674 0.665806900986108 Nonsignificant None 7 Biological Process:activation of MAPKK activity (GO:0000186),Biological Process:cellular glucose homeostasis (GO:0001678),Cellular Component:extracellular space (GO:0005615),Biological Process:G-protein coupled receptor signaling pathway (GO:0007186),Biological Process:adult feeding behavior (GO:0008343),Biological Process:cellular response to starvation (GO:0009267),Biological Process:negative regulation of appetite (GO:0032099) -- -- -- -- -- -- IPR009106 [CART satiety factor] -- -- Q9ESW8 Pyroglutamyl-peptidase 1 Pgpep1 56 44.9 52.2 45.2 44.5 42.9 1.15460030165913 0.109230525830421 0.2073935073872 Nonsignificant None -- -- pyroglutamyl-peptidase 3.4.19.3 -- Predicted pyroglutamyl peptidase O Posttranslational modification, protein turnover, chaperones ; IPR016125 [Peptidase C15, pyroglutamyl peptidase I-like] -- -- Q62101 Serine/threonine-protein kinase D1 Prkd1 110.9 101.8 108 113.6 130.1 114.2 0.896060352053646 0.109011549448902 -0.158332189974737 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468),Biological Process:intracellular signal transduction (GO:0035556) protein kinase D 2.7.11.13 ko04015 Rap1 signaling pathway ko04925 Aldosterone synthesis and secretion Serine/threonine protein kinase PKC mu/PKD and related proteins T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR001849[Pleckstrin homology domain] ; IPR002219[Protein kinase C-like, phorbol ester/diacylglycerol-binding domain] -- -- Q3TMH2 Secernin-3 Scrn3 862.6 887.3 836.9 745.9 698.7 709 1.20115156017831 0.00211053527662147 0.26441820043756 Nonsignificant None 2 Biological Process:proteolysis (GO:0006508),Molecular Function:dipeptidase activity (GO:0016805) secernin -- -- -- -- -- IPR005322 [Peptidase C69, dipeptidase A] -- -- Q3U523 Ankyrin repeat domain-containing protein 49 Ankrd49 19.5 19.6 12.4 17.9 11.2 22.2 1.00389863547758 0.98747110965032 0.00561360646352685 Nonsignificant None -- -- ankyrin repeat domain-containing protein 49 -- -- Fetal globin-inducing factor (contains ankyrin repeats) K Transcription ; -- -- -- Q9JHI9 Solute carrier family 40 member 1 Slc40a1 18.2 10.4 13.5 14.7 15.3 16.5 0.905376344086022 0.562936275110123 -0.143410482928998 Nonsignificant None 3 Molecular Function:iron ion transmembrane transporter activity (GO:0005381),Cellular Component:integral component of membrane (GO:0016021),Biological Process:iron ion transmembrane transport (GO:0034755) solute carrier family 40 (iron-regulated transporter), member 1 -- ko04216 Ferroptosis ko04978 Mineral absorption Iron transporter P Inorganic ion transport and metabolism ; IPR009716 [Ferroporti-1] -- -- Q5DU09 Zinc finger protein 652 Znf652 135.6 144.3 136 177.9 178.3 163.3 0.800577478344562 0.00372615695605566 -0.320887064145218 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) -- -- -- FOG: Zn-finger R General function prediction only ; IPR007087 [Zinc finger, C2H2] -- zf-C2H2 Q80WG7 E3 ubiquitin-protein ligase Trim36 Trim36 37 31.1 31 36.6 36.1 43.5 0.852839931153184 0.140203773495588 -0.229653106218041 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Cellular Component:intracellular (GO:0005622),Molecular Function:zinc ion binding (GO:0008270) tripartite motif-containing protein 36 2.3.2.27 -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR000315 [B-box-type zinc finger] ; IPR003961[Fibronectin type III] ; IPR027370[RING-type zinc-finger, LisH dimerisation motif] -- -- A2AF58 Synaptotagmin-like 5 Sytl5 356.2 432.9 93.1 804.5 1003.2 458.5 0.389286029476657 0.0716455711219364 -1.36109752406911 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) synaptotagmin-like protein -- -- Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR000008 [C2 domain] ; IPR011011[Zinc finger, FYVE/PHD-type] -- -- Q9ES88 Solute carrier family 13 member 2 Slc13a2 132.7 107.3 126.1 130.7 123.5 136.9 0.936077729480951 0.38429098292052 -0.0952997624283998 Nonsignificant None 4 Molecular Function:transporter activity (GO:0005215),Biological Process:sodium ion transport (GO:0006814),Cellular Component:membrane (GO:0016020),Biological Process:transmembrane transport (GO:0055085) solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2/3/5 -- -- Na+/dicarboxylate, Na+/tricarboxylate and phosphate transporters P Inorganic ion transport and metabolism ; IPR001898 [Sodium/sulphate symporter] -- -- Q6A049 MKIAA0546 protein (Fragment) Zfc3h1 117.8 137.8 70.1 158.8 193.4 127.7 0.678683058970619 0.136331538039957 -0.55919009332029 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019607 [Putative zinc-finger domain] -- -- Q3TXN3 Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Mgat2 170.7 182.4 256.1 218.2 232 225.4 0.901716992303138 0.49568913487047 -0.149253386314094 Nonsignificant None 4 Cellular Component:Golgi stack (GO:0005795),Molecular Function:alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity (GO:0008455),Biological Process:oligosaccharide biosynthetic process (GO:0009312),Cellular Component:integral component of membrane (GO:0016021) alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 2.4.1.143 ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways N-acetylglucosaminyltransferase G Carbohydrate transport and metabolism ; IPR007754 [N-acetylglucosaminyltransferase II] -- -- Q80U30 Protein CLEC16A Clec16a 122.5 114.7 110.5 124.2 148.7 120.3 0.884282807731434 0.187756943962612 -0.177420254612953 Nonsignificant None -- -- protein CLEC16A -- -- Uncharacterized conserved protein S Function unknown ; IPR019155 [Uncharacterised protein family FPL] -- -- B2RPV4 C430048L16Rik protein Rbm12b2 85.3 60.6 60.7 70.4 64.8 72.3 0.99566265060241 0.973596881828001 -0.00627108225658991 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- RNA binding protein RBM12/SWAN R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- A0A140LIY9 Glutamine-rich protein 2 Qrich2 552.3 489.7 498.4 393 440.5 412 1.23677238057005 0.0148102685117107 0.306580006668787 Nonsignificant None -- -- -- -- -- -- -- -- IPR032013 [Protein of unknown function DUF4795] -- -- Q6PDZ2 TATA box-binding protein-associated factor RNA polymerase I subunit C Taf1c 55.6 62.4 56.9 37.9 62.2 46.4 1.1938566552901 0.270973185175526 0.255629624612042 Nonsignificant None -- -- TATA box-binding protein-associated factor RNA polymerase I subunit C -- -- -- -- -- -- -- -- Q9CRA9 FGFR1 oncogene partner 2 homolog Fgfr1op2 294.4 310.7 375 318.5 291.5 345.6 1.02563834240268 0.793192514696669 0.036522101702887 Nonsignificant None -- -- -- -- -- -- -- -- IPR008555 [Suppressor of IKBKE 1] -- -- Q6P4S6 Serine/threonine-protein kinase SIK3 Sik3 94 109 72.3 57.4 58.3 66.3 1.51263736263736 0.0477515028498514 0.597066159509503 Significant up 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) serine/threonine-protein kinase SIK3 2.7.11.1 -- -- -- -- IPR000719 [Protein kinase domain] -- -- A0A0A0MQ73 [Histone H3]-lysine(4) N-methyltransferase Kmt2d 35 34.8 39.8 41.7 41.6 38.6 0.89909762100082 0.100220299941362 -0.153450327659685 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:nucleus (GO:0005634) histone-lysine N-methyltransferase MLL2 2.1.1.43 ko00310 Lysine degradation Putative transcription factor HALR/MLL3, involved in embryonic development R General function prediction only ; IPR001214 [SET domain] ; IPR003888[FY-rich, N-terminal] ; IPR003889[FY-rich, C-terminal] ; IPR019787[Zinc finger, PHD-finger] -- -- Q91WL8 WW domain-containing oxidoreductase Wwox 148.8 138.4 137.4 148.6 142.4 138.9 0.98767155152361 0.721515512663371 -0.0178967390779243 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) WW domain-containing oxidoreductase -- -- Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Q Secondary metabolites biosynthesis, transport and catabolism ; IPR001202 [WW domain] ; IPR002347[Short-chain dehydrogenase/reductase SDR] -- -- Q3US38 Uncharacterized protein (Fragment) Rbm45 4.6 8 0 9 8.1 9.5 0.710526315789474 0.15835417341599 -0.493040011280117 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- -- -- -- IPR000504 [RNA recognition motif domain] -- -- O09130 NFATC2-interacting protein Nfatc2ip 40.9 34.5 39.3 30.1 42.5 33.1 1.08514664143803 0.514618905370744 0.117890014633142 Nonsignificant None -- -- -- -- -- Ubiquitin-like proteins O Posttranslational modification, protein turnover, chaperones ; IPR022617 [Rad60/SUMO-like domain] -- -- A0A141CM32 ATP synthase protein 8 ATP8 57.6 61.7 74.5 89.4 60.2 72.8 0.871402877697842 0.388761378406238 -0.198588217308427 Nonsignificant None 2 Molecular Function:hydrogen ion transmembrane transporter activity (GO:0015078),Biological Process:ATP synthesis coupled proton transport (GO:0015986) F-type H+-transporting ATPase subunit 8 -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease -- -- -- IPR001421 [ATP synthase protein 8, metazoa] -- -- Q6ZWS1 Multifunctional fusion protein Fgf1 12.8 10.4 19.2 15.5 19.5 14.7 0.853118712273642 0.465150291168316 -0.229181586999087 Nonsignificant None 1 Molecular Function:growth factor activity (GO:0008083) fibroblast growth factor 1 -- ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04151 PI3K-Akt signaling pathway ko04390 Hippo signaling pathway ko04810 Regulation of actin cytoskeleton ko05200 Pathways in cancer ko05218 Melanoma ko05224 Breast cancer ko05226 Gastric cancer Fibroblast growth factor T Signal transduction mechanisms ; IPR002209 [Fibroblast growth factor family] -- -- Q8VE38 Oxidoreductase NAD-binding domain-containing protein 1 Oxnad1 226.7 221.4 229.1 281.7 312.4 257.3 0.795395818651633 0.0650360244539218 -0.330255116886066 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) -- -- -- NADH-cytochrome b-5 reductase HC Coenzyme transport and metabolism ; Energy production and conversion ; IPR001433 [Oxidoreductase FAD/NAD(P)-binding] -- -- Q05DG8 Slc22a18 protein Slc22a18 457 352.2 347.6 356.8 351.1 404.5 1.03991370010787 0.727131629931761 0.0564638076044309 Nonsignificant None 2 Cellular Component:integral component of membrane (GO:0016021),Biological Process:transmembrane transport (GO:0055085) MFS transporter, OCT family, solute carrier family 22 (organic cation transporter), member 18 -- -- -- -- -- IPR011701 [Major facilitator superfamily] -- -- V9GXX7 DNA repair protein SWI5 homolog (Fragment) Swi5 289 247.6 245.4 244.2 271.8 269.5 0.995544239338001 0.947693753911051 -0.00644266798684386 Nonsignificant None -- -- -- -- -- -- -- -- IPR010760 [DNA repair protein, Swi5] -- -- Q3UPR9 Somatomedin-B and thrombospondin type-1 domain-containing protein Sbspon 372.6 403.9 518.7 486.8 427.8 516.7 0.904911618808077 0.428302367686651 -0.144151201402895 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- P28574 Protein max Max 262.1 284.7 408.8 485 473.4 467.6 0.670126227208976 0.0734029077320452 -0.577495222874918 Nonsignificant None 1 Molecular Function:protein dimerization activity (GO:0046983) Max protein -- ko04010 MAPK signaling pathway ko05200 Pathways in cancer ko05202 Transcriptional misregulation in cancer ko05222 Small cell lung cancer Upstream transcription factor 2/L-myc-2 protein K Transcription ; IPR011598 [Myc-type, basic helix-loop-helix (bHLH) domain] -- bHLH P70277 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 St6galnac2 162.2 163.3 169 141.9 129.7 152.1 1.16709936275667 0.0256796404753614 0.222927392282583 Nonsignificant None 2 Biological Process:protein glycosylation (GO:0006486),Molecular Function:sialyltransferase activity (GO:0008373) alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7B) 2.4.99.- -- Sialyltransferase G Carbohydrate transport and metabolism ; IPR001675 [Glycosyl transferase family 29] -- -- Q8R1Q9 Ribokinase Rbks 47.9 38.6 42.3 63.5 75.6 71.1 0.612749762131303 0.00365063681149763 -0.706630075847561 Significant down -- -- ribokinase 2.7.1.15 ko00030 Pentose phosphate pathway Ribokinase G Carbohydrate transport and metabolism ; IPR011611 [Carbohydrate kinase PfkB] -- -- O08641 SH3 domain-containing YSC84-like protein 1 Sh3yl1 162.2 199.2 159.1 159.2 189.7 163.9 1.01501560062402 0.880284481637837 0.0215019015680384 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) SH3 domain-containing YSC84-like protein 1 -- -- Uncharacterized conserved protein S Function unknown ; IPR001452 [SH3 domain] ; IPR007461[Ysc84 actin-binding domain] -- -- Q3USH5 Splicing factor, suppressor of white-apricot homolog Sfswap 103.3 96.2 102.2 93.6 90 108.4 1.03321917808219 0.621192987402583 0.0471463273793227 Nonsignificant None 2 Molecular Function:RNA binding (GO:0003723),Biological Process:RNA processing (GO:0006396) -- -- -- mRNA splicing factor A RNA processing and modification ; IPR000061 [SWAP/Surp] ; IPR019147[Suppressor of white apricot N-terminal domain] -- -- Q6PAQ4 RNA exonuclease 4 Rexo4 164.2 164.6 113.2 121.1 111.5 117 1.26430205949657 0.149483162915662 0.338341184778195 Nonsignificant None -- -- RNA exonuclease 4 3.1.-.- -- 3'-5' exonuclease L Replication, recombination and repair ; IPR013520 [Exonuclease, RNase T/DNA polymerase III] -- -- Q80Y83 Dixin Dixdc1 409.1 407.3 438 352.7 382.7 369.4 1.13540912382332 0.019477187666875 0.183212239857157 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR001158 [DIX domain] ; IPR001715[Calponin homology domain] -- -- Q8K2X8 General transcription factor IIH subunit 5 Gtf2h5 121.3 112.9 159.4 218.8 205.7 206.5 0.623771790808241 0.00607422506383995 -0.680909784530672 Significant down 2 Cellular Component:core TFIIH complex (GO:0000439),Biological Process:nucleotide-excision repair (GO:0006289) TFIIH basal transcription factor complex TTD-A subunit -- ko03022 Basal transcription factors ko03420 Nucleotide excision repair Uncharacterized conserved protein S Function unknown ; IPR009400 [TFIIH subunit TTDA/Tfb5] -- -- Q9DBL2 Ganglioside-induced differentiation-associated protein 2 Gdap2 90.5 82.9 86 70 77.8 87 1.10477001703578 0.202531102430598 0.143746071141647 Nonsignificant None -- -- -- -- -- Hismacro and SEC14 domain-containing proteins BK Chromatin structure and dynamics ; Transcription ; IPR001251 [CRAL-TRIO lipid binding domain] ; IPR002589[Macro domain] -- -- Q9WVK8 Cholesterol 24-hydroxylase Cyp46a1 261.3 259.4 250.6 271.7 252.3 253.2 0.992408646423057 0.796331230495377 -0.0109937900305322 Nonsignificant None 3 Molecular Function:iron ion binding (GO:0005506),Molecular Function:heme binding (GO:0020037),Biological Process:oxidation-reduction process (GO:0055114) cholesterol 24-hydroxylase 1.14.14.25 ko00120 Primary bile acid biosynthesis Cytochrome P450 CYP4/CYP19/CYP26 subfamilies QI Secondary metabolites biosynthesis, transport and catabolism ; Lipid transport and metabolism ; IPR001128 [Cytochrome P450] -- -- Q9CPR1 RWD domain-containing protein 4 Rwdd4 107.7 106.3 99.7 96.1 97.9 106.1 1.04531822725758 0.314438541725866 0.0639422102453144 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Uncharacterized conserved protein, contains RWD domain S Function unknown ; IPR006575 [RWD domain] -- -- Q9DB42 Zinc finger protein 593 Znf593 158 171.9 159.1 147.4 149.8 148.7 1.09665844359722 0.0810625830203811 0.133114265525692 Nonsignificant None -- -- bud site selection protein 20 -- -- U1-like Zn-finger-containing protein, probabl erole in RNA processing/splicing A RNA processing and modification ; IPR022755 [Zinc finger, double-stranded RNA binding] -- -- Q9CQK3 RAD52 motif-containing protein 1 Rdm1 90.6 103.7 130.8 132.1 133.4 118.6 0.846394168185369 0.197754763907451 -0.240598407840709 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) RAD52 motif-containing protein 1 -- -- -- -- -- IPR000504 [RNA recognition motif domain] -- -- E0CXB5 Pituitary tumor-transforming gene 1 protein-interacting protein (Fragment) Pttg1ip 141.7 198.1 248.1 233.2 233.9 200.7 0.880353399221324 0.460147182929706 -0.183845315504856 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- P70196 TNF receptor-associated factor 6 Traf6 205.5 246 195.6 184.8 186.6 177.8 1.17825928623452 0.105387248080398 0.23665705173451 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) TNF receptor-associated factor 6 2.3.2.27 ko04010 MAPK signaling pathway ko04064 NF-kappa B signaling pathway ko04120 Ubiquitin mediated proteolysis ko04140 Autophagy - animal ko04144 Endocytosis ko04380 Osteoclast differentiation ko04620 Toll-like receptor signaling pathway ko04621 NOD-like receptor signaling pathway ko04622 RIG-I-like receptor signaling pathway ko04657 IL-17 signaling pathway ko04722 Neurotrophin signaling pathway ko05133 Pertussis ko05140 Leishmaniasis ko05142 Chagas disease (American trypanosomiasis) ko05145 Toxoplasmosis ko05152 Tuberculosis ko05160 Hepatitis C ko05162 Measles ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05222 Small cell lung cancer TNF receptor-associated factor T Signal transduction mechanisms ; IPR001293 [Zinc finger, TRAF-type] -- -- P83877 Thioredoxin-like protein 4A Txnl4a 232.5 250 192.3 183.6 189.9 180.8 1.21739130434783 0.139865329614402 0.283792966000591 Nonsignificant None 1 Cellular Component:spliceosomal complex (GO:0005681) U5 snRNP protein, DIM1 family -- ko03040 Spliceosome Component of the U4/U6.U5 snRNP/mitosis protein DIM1 AD RNA processing and modification ; Cell cycle control, cell division, chromosome partitioning ; IPR004123 [Dim1 family] -- -- Q6NVG1 Lysophospholipid acyltransferase LPCAT4 Lpcat4 8.4 7.8 8.5 11.4 11.2 11.1 0.732937685459941 0.000219511419205988 -0.448237549597181 Nonsignificant None 1 Biological Process:metabolic process (GO:0008152) -- -- ko00564 Glycerophospholipid metabolism ko00565 Ether lipid metabolism ko01100 Metabolic pathways -- -- -- IPR002123 [Phospholipid/glycerol acyltransferase] -- -- Q8C359 Uncharacterized protein Gabpb2 13.1 17.1 15.1 15.5 19.9 15.5 0.889980353634578 0.373900966300059 -0.16815460602946 Nonsignificant None -- -- GA-binding protein transcription factor, beta -- -- -- -- -- -- -- -- Q8R5A6 TBC1 domain family member 22A Tbc1d22a 197.8 192 232.2 225.3 223 223.8 0.925457521202202 0.314484085392818 -0.111761323438062 Nonsignificant None -- -- TBC1 domain family member 2 -- -- Ypt/Rab-specific GTPase-activating protein GYP1 U Intracellular trafficking, secretion, and vesicular transport ; IPR000195 [Rab-GTPase-TBC domain] -- -- B1B1D3 Zinc finger protein 40 Zfp40 56.7 55.9 38.5 47.8 55.6 44 1.02510176390773 0.865858005018437 0.0357671360697593 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Cellular Component:intracellular (GO:0005622),Molecular Function:metal ion binding (GO:0046872) KRAB domain-containing zinc finger protein -- -- FOG: Zn-finger R General function prediction only ; IPR001909 [Krueppel-associated box] ; IPR007087[Zinc finger, C2H2] -- zf-C2H2 D3YY94 Syntaxin-2 (Fragment) Stx2 224.4 210.8 223.4 226.3 218.6 202.2 1.01777159635296 0.669866912448315 0.0254138347137375 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) syntaxin 1B/2/3 -- ko04130 SNARE interactions in vesicular transport ko04721 Synaptic vesicle cycle SNARE protein Syntaxin 1 and related proteins U Intracellular trafficking, secretion, and vesicular transport ; IPR006011 [Syntaxin, N-terminal domain] -- -- A0A1Y7VKS9 Mammalian ependymin-related protein 1 Epdr1 165.7 156.7 206.1 204.3 211.2 203.9 0.853245075879884 0.181589385322056 -0.228967911404618 Nonsignificant None 3 Molecular Function:calcium ion binding (GO:0005509),Cellular Component:extracellular region (GO:0005576),Biological Process:cell-matrix adhesion (GO:0007160) -- -- -- -- -- -- IPR001299 [Ependymin] -- -- Q69ZF3 Non-lysosomal glucosylceramidase Gba2 258.6 315.6 43.7 474 554.4 241.4 0.486612064892109 0.157498461237235 -1.03915600448312 Nonsignificant None -- -- non-lysosomal glucosylceramidase 3.2.1.45 ko00511 Other glycan degradation ko00600 Sphingolipid metabolism ko01100 Metabolic pathways Predicted bile acid beta-glucosidase G Carbohydrate transport and metabolism ; IPR006775 [Glycosyl-hydrolase family 116, catalytic region] ; IPR024462[Glycosyl-hydrolase family 116, N-terminal] -- -- Q9QWK4 CD5 antigen-like Cd5l 78.5 74 92 73.7 119.6 76.5 0.906226834692365 0.621989030383835 -0.142055883108672 Nonsignificant None 2 Molecular Function:scavenger receptor activity (GO:0005044),Cellular Component:membrane (GO:0016020) -- -- -- -- -- -- IPR001190 [SRCR domain] -- -- E9Q1I2 SOSS complex subunit B1 (Fragment) Nabp2 315.1 303.7 290.4 257.1 255.8 271.7 1.15880703543207 0.0090668577614542 0.212640348740752 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- Predicted nucleic acid binding protein R General function prediction only ; IPR004365 [OB-fold nucleic acid binding domain, AA-tRNA synthetase-type] -- -- Q8BQQ5 Uncharacterized protein Casp12 61.2 58.1 71.2 72.5 71.4 74.4 0.872652313330279 0.0839624055980318 -0.196521132610107 Nonsignificant None 1 Biological Process:regulation of apoptotic process (GO:0042981) caspase 12 3.4.22.- ko04141 Protein processing in endoplasmic reticulum ko04210 Apoptosis ko04621 NOD-like receptor signaling pathway ko05010 Alzheimer's disease ko05014 Amyotrophic lateral sclerosis (ALS) ko05020 Prion diseases ko05161 Hepatitis B Caspase, apoptotic cysteine protease D Cell cycle control, cell division, chromosome partitioning ; IPR001315 [CARD domain] -- -- A0A087WQU2 Retinoblastoma-binding protein 5 (Fragment) Rbbp5 331.9 311.1 319 319.1 330.1 306.6 1.0064867127014 0.831497147102818 0.00932812641093819 Nonsignificant None -- -- COMPASS component SWD1 -- -- WD40 repeat protein R General function prediction only ; -- -- -- Q3TT68 Pre-mRNA-splicing factor 18 Prpf18 14.5 11.8 18.1 22.8 15.3 19.6 0.76949740034662 0.193218287041196 -0.378011642295377 Nonsignificant None 2 Cellular Component:spliceosomal complex (GO:0005681),Biological Process:RNA splicing (GO:0008380) pre-mRNA-splicing factor 18 -- ko03040 Spliceosome U5 snRNP-associated RNA splicing factor A RNA processing and modification ; IPR004098 [Prp18] -- -- A0A0A6YXN6 Zinc finger CCCH domain-containing protein 11A (Fragment) Zc3h11a 176.1 159.2 152.2 198.4 199.8 190.7 0.827814569536424 0.0114600235762378 -0.272620454662992 Nonsignificant None -- -- Uncharacterized conserved protein S Function unknown ; -- -- -- P04444 Hemoglobin subunit beta-H1 Hbb-bh1 42 34 45.1 29.5 38.6 35.3 1.17117988394584 0.236800462885705 0.227962679379394 Nonsignificant None 2 Molecular Function:oxygen binding (GO:0019825),Molecular Function:heme binding (GO:0020037) hemoglobin subunit epsilon -- -- Globins and related hemoproteins C Energy production and conversion ; IPR000971 [Globin] -- -- Q6IM74 Reticulon Rtn2 62.1 53.3 51.1 73.1 64.8 70.8 0.797795879252516 0.0280222748986356 -0.32590842320121 Nonsignificant None -- -- reticulon-2 -- -- Reticulon U Intracellular trafficking, secretion, and vesicular transport ; IPR003388 [Reticulon] -- -- Q8R3L2 Transcription factor 25 Tcf25 55.1 89.5 108.8 98.9 110.2 94.5 0.834650856389987 0.364899509381567 -0.260755266274657 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR006994 [Transcription factor 25] -- -- Q8K394 Inactive phospholipase C-like protein 2 Plcl2 20 24.6 25.8 28.5 23.9 25.8 0.900255754475703 0.305559774667499 -0.151593178670055 Nonsignificant None 5 Molecular Function:phosphatidylinositol phospholipase C activity (GO:0004435),Molecular Function:protein binding (GO:0005515),Biological Process:lipid metabolic process (GO:0006629),Biological Process:signal transduction (GO:0007165),Biological Process:intracellular signal transduction (GO:0035556) inactive phospholipase C-like protein 2 -- -- Phosphoinositide-specific phospholipase C T Signal transduction mechanisms ; IPR000008 [C2 domain] ; IPR000909[Phosphatidylinositol-specific phospholipase C, X domain] ; IPR001711[Phospholipase C, phosphatidylinositol-specific, Y domain] ; IPR001849[Pleckstrin homology domain] ; IPR015359[Phosphoinositide-specific phospholipase C, EF-hand-like domain] -- -- Q8BWR4 Ubiquitin carboxyl-terminal hydrolase 40 Usp40 179.4 170.6 150 154.7 140.4 150.4 1.12233445566779 0.134001959123716 0.166502663140165 Nonsignificant None 2 Biological Process:protein deubiquitination (GO:0016579),Molecular Function:thiol-dependent ubiquitinyl hydrolase activity (GO:0036459) ubiquitin carboxyl-terminal hydrolase 40 3.4.19.12 -- Ubiquitin carboxyl-terminal hydrolase O Posttranslational modification, protein turnover, chaperones ; IPR001394 [Peptidase C19, ubiquitin carboxyl-terminal hydrolase] -- -- Q3USZ8 Divergent protein kinase domain 2A Dipk2a 41.2 42.7 46.2 38.5 43.8 41.9 1.0475040257649 0.410942684956161 0.066955788497314 Nonsignificant None -- -- -- -- -- -- -- -- IPR022049 [FAM69, protein-kinase domain] -- -- Q9D8C3 Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 Alg13 233.9 247.9 225.6 195.4 230.9 177.3 1.17196819085487 0.112059780401691 0.228933413174235 Nonsignificant None -- -- beta-1,4-N-acetylglucosaminyltransferase 2.4.1.141 ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways -- -- -- IPR003323 [OTU domain] ; IPR007235[Glycosyl transferase, family 28, C-terminal] -- -- Q8CIM3 D-2-hydroxyglutarate dehydrogenase, mitochondrial D2hgdh 152.3 136.4 157.2 105.8 115.4 106.7 1.35986581274779 0.00489188176119752 0.443464297920844 Nonsignificant None 4 Molecular Function:catalytic activity (GO:0003824),Molecular Function:oxidoreductase activity (GO:0016491),Molecular Function:flavin adenine dinucleotide binding (GO:0050660),Biological Process:oxidation-reduction process (GO:0055114) D-2-hydroxyglutarate dehydrogenase 1.1.99.39 -- Proteins containing the FAD binding domain C Energy production and conversion ; IPR004113 [FAD-linked oxidase, C-terminal] ; IPR006094[FAD linked oxidase, N-terminal] -- -- E9QNY8 Sacsin Sacs 498.4 299.4 215.7 250.7 351.8 303.6 1.11852996358018 0.707388270116512 0.161603904344746 Nonsignificant None -- -- sacsin -- -- -- -- -- IPR007842 [HEPN domain] -- -- Q9ESJ4 NCK-interacting protein with SH3 domain Nckipsd 37.6 40 35.4 39.7 37.7 43.8 0.932343234323432 0.288156661154563 -0.101066926170401 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Coeffector of mDia Rho GTPase, regulates actin polymerization and cell adhesion turnover TZ Signal transduction mechanisms ; Cytoskeleton ; IPR001452 [SH3 domain] ; IPR018556[Domain of unknown function DUF2013] -- -- B1ARV6 PRAME-like 15 Pramel15 303 302.3 273.7 207 203.3 210.9 1.41500321957502 0.000968923218216322 0.500805335643465 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q3USX4 Uncharacterized protein Them4 59.1 38.4 41.8 52.9 47.1 56.8 0.888392857142857 0.451591280435404 -0.170730301513955 Nonsignificant None -- -- thioesterase superfamily member 4 -- ko04151 PI3K-Akt signaling pathway Uncharacterized conserved protein S Function unknown ; -- -- -- Q3TQB2 FAD-dependent oxidoreductase domain-containing protein 1 Foxred1 214.1 204.1 184.9 149.6 162.3 169.9 1.25176421751764 0.0178064764570076 0.323962841621557 Nonsignificant None 2 Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) FAD-dependent oxidoreductase domain-containing protein 1 -- -- Possible oxidoreductase R General function prediction only ; IPR006076 [FAD dependent oxidoreductase] -- -- Q3TC68 Uncharacterized protein Alox5 159 182.3 152.8 108.1 100.1 112.8 1.5392523364486 0.0040303377947457 0.622229758437846 Significant up 3 Molecular Function:protein binding (GO:0005515),Molecular Function:metal ion binding (GO:0046872),Biological Process:oxidation-reduction process (GO:0055114) arachidonate 5-lipoxygenase 1.13.11.34 ko00590 Arachidonic acid metabolism ko01100 Metabolic pathways ko04664 Fc epsilon RI signaling pathway ko04726 Serotonergic synapse ko04913 Ovarian steroidogenesis ko05145 Toxoplasmosis -- -- -- IPR001024 [PLAT/LH2 domain] ; IPR013819[Lipoxygenase, C-terminal] -- -- Q3TQ22 Uncharacterized protein (Fragment) Fbxw8 52.5 51.8 61.5 84.9 88.3 58.9 0.714347264110297 0.0870747205988619 -0.485302515848732 Nonsignificant None -- -- F-box and WD-40 domain protein 8 -- ko04120 Ubiquitin mediated proteolysis -- -- -- -- -- -- Q9QUG9 RAS guanyl-releasing protein 2 Rasgrp2 62.1 60 67.9 69.6 78.2 74.4 0.855085508550855 0.0352437513914698 -0.225859398170782 Nonsignificant None 4 Molecular Function:guanyl-nucleotide exchange factor activity (GO:0005085),Molecular Function:calcium ion binding (GO:0005509),Biological Process:small GTPase mediated signal transduction (GO:0007264),Biological Process:intracellular signal transduction (GO:0035556) RAS guanyl-releasing protein 2 -- ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04062 Chemokine signaling pathway ko04611 Platelet activation ko05200 Pathways in cancer Ras1 guanine nucleotide exchange factor T Signal transduction mechanisms ; IPR000651 [Ras-like guanine nucleotide exchange factor, N-terminal] ; IPR001895[Ras guanine-nucleotide exchange factors catalytic domain] ; IPR002048[EF-hand domain] ; IPR002219[Protein kinase C-like, phorbol ester/diacylglycerol-binding domain] -- -- Q0VDQ9 Fez family zinc finger protein 1 Fezf1 67.3 61.6 55.2 51.9 64 52.3 1.09453032104637 0.372922267903698 0.130311921094762 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) -- -- -- FOG: Zn-finger R General function prediction only ; IPR007087 [Zinc finger, C2H2] -- zf-C2H2 P28231 Gap junction beta-3 protein Gjb3 39.2 45.7 47.5 51.1 53.2 52.3 0.845466155810983 0.0358456638196604 -0.242181090483823 Nonsignificant None -- -- gap junction beta-3 protein -- -- -- -- -- IPR013092 [Connexin, N-terminal] -- -- P51162 Gastrotropin Fabp6 119.2 104.1 112.4 141 143.9 112.1 0.8455919395466 0.138132630140409 -0.24196647033277 Nonsignificant None -- -- fatty acid-binding protein 6, ileal (gastrotropin) -- ko03320 PPAR signaling pathway Fatty acid-binding protein FABP I Lipid transport and metabolism ; -- -- -- A0A2K6EDL8 Collagen alpha-1(XX) chain Col20a1 85.8 108.4 41.2 63.9 75.8 77.8 1.08229885057471 0.782542793250928 0.114098919414991 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Collagens (type IV and type XIII), and related proteins W Extracellular structures ; IPR002035 [von Willebrand factor, type A] ; IPR003961[Fibronectin type III] ; IPR008160[Collagen triple helix repeat] -- -- A0A286YD43 Transcription factor AP-2-alpha Tfap2a 224.6 250.7 72.5 156.5 173.7 215.6 1.00366434591425 0.991419352145758 0.00527687143123754 Nonsignificant None -- -- transcription factor AP-2 alpha/beta -- -- Transcription factor AP-2 K Transcription ; IPR013854 [Transcription factor AP-2, C-terminal] -- AP-2 Q8CIV2 Membralin Tmem259 54.4 44.1 43.1 43.6 41.6 43.7 1.09852598913887 0.313600406968142 0.135569001721347 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019144 [Membralin] -- -- Q3TCX3 KH homology domain-containing protein 4 Khdc4 64.3 70.6 92.3 83.7 83 77.2 0.931529315293153 0.55825571108782 -0.102326923291502 Nonsignificant None -- -- -- -- -- Predicted RNA-binding protein, contains KH domains A RNA processing and modification ; -- -- -- D3Z774 Histone-lysine N-methyltransferase EZH2 Ezh2 280.5 275.1 286.6 233.7 237.7 238.6 1.18619718309859 0.000269141885242618 0.246343850889687 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:histone-lysine N-methyltransferase activity (GO:0018024) histone-lysine N-methyltransferase EZH2 2.1.1.43 ko00310 Lysine degradation ko05206 MicroRNAs in cancer Transcriptional repressor EZH1 K Transcription ; IPR001214 [SET domain] ; IPR021654[Histone-lysine N-methyltransferase EZH1/EZH2] -- -- Q5DU37 Zinc finger FYVE domain-containing protein 26 Zfyve26 43.3 47 45.1 55.4 53 48 0.865728900255754 0.0448434051508332 -0.208012773732356 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) zinc finger FYVE domain-containing protein 26 -- -- Predicted Zn2+-binding protein, contains FYVE domain R General function prediction only ; IPR000306 [FYVE zinc finger] -- -- Q80WF6 Sulfate anion transporter 1 Slc26a1 173.8 243.4 69.8 354.1 401.5 214 0.50226897689769 0.100392259095892 -0.993467926503246 Nonsignificant None 3 Biological Process:sulfate transport (GO:0008272),Molecular Function:sulfate transmembrane transporter activity (GO:0015116),Cellular Component:integral component of membrane (GO:0016021) solute carrier family 26 (sulfate anion transporter), member 1 -- -- Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) P Inorganic ion transport and metabolism ; IPR002645 [STAS domain] ; IPR011547[SLC26A/SulP transporter domain] -- -- Q7TPE5 Probable RNA polymerase II nuclear localization protein SLC7A6OS Slc7a6os 40 39.8 26.1 20.2 24.5 23.8 1.54598540145985 0.0598586988954852 0.628526696144447 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR013883 [Transcription factor Iwr1] -- -- Q811G4 Zfp532 protein Zfp532 69.5 70.8 63.2 69.6 66.2 65.4 1.01143141153082 0.788789223036628 0.0163984893480824 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) -- -- -- FOG: Zn-finger R General function prediction only ; IPR007087 [Zinc finger, C2H2] -- zf-C2H2 D3Z4G2 Homeobox protein OTX2 (Fragment) Otx2 161.1 162 136.6 157.9 191.4 138.3 0.942780968006563 0.625070967298517 -0.0850054598034084 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) homeobox protein OTX2 -- -- Homeobox transcription factor K Transcription ; IPR001356 [Homeobox domain] -- Homeobox A0A075B677 Immunoglobulin kappa variable 4-53 Igkv4-53 38.9 54.8 63.5 36.4 47.3 33.3 1.34358974358974 0.184234417336459 0.426092687787839 Nonsignificant None -- -- pre-B lymphocyte gene -- -- -- -- -- IPR013106 [Immunoglobulin V-set domain] -- -- P70314 Pituitary homeobox 1 Pitx1 194.6 268.9 124.5 506.8 564 296.2 0.430138990490124 0.0469350698734425 -1.2171251827697 Significant down 1 Molecular Function:DNA binding (GO:0003677) paired-like homeodomain transcription factor 1 -- -- Transcription factor PTX1, contains HOX domain K Transcription ; IPR001356 [Homeobox domain] ; IPR003654[OAR domain] -- Homeobox Q3U0Z3 Death domain-associated protein 6 Daxx 55.2 49.4 40.7 43.3 39.6 52.2 1.07549962990378 0.578703513008903 0.105007028307157 Nonsignificant None -- -- death-associated protein 6 -- ko04010 MAPK signaling pathway ko04210 Apoptosis ko05014 Amyotrophic lateral sclerosis (ALS) ko05168 Herpes simplex infection -- -- -- IPR031333 [Daxx, N-terminal Rassf1C-interacting domain] -- -- Q80U52 Sodium/hydrogen exchanger (Fragment) Slc9a6 30.2 26.5 25.3 29.9 22.1 31.8 0.978520286396181 0.865129550060834 -0.0313263341939056 Nonsignificant None 4 Biological Process:cation transport (GO:0006812),Molecular Function:solute:proton antiporter activity (GO:0015299),Cellular Component:integral component of membrane (GO:0016021),Biological Process:transmembrane transport (GO:0055085) solute carrier family 9 (sodium/hydrogen exchanger), member 6/7 -- -- Sodium/hydrogen exchanger protein P Inorganic ion transport and metabolism ; IPR006153 [Cation/H+ exchanger] -- -- Q9WU63 Heme-binding protein 2 Hebp2 79.7 82.1 287.1 378.8 365.1 358 0.407387240221436 0.0857794539460461 -1.29552730053727 Nonsignificant None -- -- -- -- -- -- -- -- IPR006917 [SOUL haem-binding protein] -- -- Q3URY2 Geminin coiled-coil domain-containing protein 1 Gmnc 162.6 142.3 161.3 159 154.2 182.7 0.94010889292196 0.418394774567119 -0.0891002208846035 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- P61600 N-alpha-acetyltransferase 20 Naa20 349.8 328.2 324.2 338.9 315.2 354.8 0.993359103974626 0.88086320755119 -0.00961274181816157 Nonsignificant None 1 Molecular Function:N-acetyltransferase activity (GO:0008080) N-terminal acetyltransferase B complex catalytic subunit 2.3.1.254 -- Acetyltransferase, (GNAT) family R General function prediction only ; IPR000182 [GNAT domain] -- -- Q9D6T3 Uncharacterized protein Ccdc115 48.7 45.7 47.5 40.5 40.7 34 1.23177083333333 0.019778010886664 0.300733872618239 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q91WW6 TATA-binding protein associated factor TAFII135 (Fragment) Taf4 43.6 37.2 33.8 54.1 49.7 44.4 0.773279352226721 0.0493197453017847 -0.370938403548929 Nonsignificant None 1 Cellular Component:transcription factor TFIID complex (GO:0005669) transcription initiation factor TFIID subunit 4 -- ko03022 Basal transcription factors ko05016 Huntington's disease ko05168 Herpes simplex infection TATA box binding protein (TBP)-associated factor, RNA polymerase II K Transcription ; IPR003894 [TAFH/NHR1] ; IPR007900[Transcription initiation factor TFIID component TAF4] -- -- F6SX81 G-protein-signaling modulator 1 (Fragment) Gpsm1 68.3 46.9 97 36.4 48 42.8 1.66823899371069 0.129933903071618 0.738325985630409 Nonsignificant None 1 Molecular Function:GTPase regulator activity (GO:0030695) G-protein signaling modulator 1 -- ko05030 Cocaine addiction Predicted G-alpha GTPase interaction protein, contains GoLoco domain T Signal transduction mechanisms ; IPR003109 [GoLoco motif] -- -- Q0VAV3 4921505C17Rik protein Rictor 183.1 172 211.8 176.9 170.4 190.6 1.0539133667968 0.506641137300751 0.0757562802298954 Nonsignificant None -- -- rapamycin-insensitive companion of mTOR -- ko04150 mTOR signaling pathway Protein required for meiosis D Cell cycle control, cell division, chromosome partitioning ; IPR028267 [Rapamycin-insensitive companion of mTOR, N-terminal domain] ; IPR029259[Rapamycin-insensitive companion of mTOR, phosphorylation-site] ; IPR029451[Rapamycin-insensitive companion of mTOR, middle domain] ; IPR029452[Rapamycin-insensitive companion of mTOR, domain 5] ; IPR029453[Rapamycin-insensitive companion of mTOR, domain 4] -- -- A0PJ58 Gpatch8 protein (Fragment) Gpatch8 39.6 37 43.1 50.9 48 52.2 0.792190602250165 0.00836192913942664 -0.336080508221327 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q6NZL1 DEAH (Asp-Glu-Ala-His) box polypeptide 37 Dhx37 172.3 174.1 156.9 149.6 171.1 136 1.10203634771185 0.251030693324198 0.140171808118548 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:helicase activity (GO:0004386),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase DHX37/DHR1 3.6.4.13 -- DEAH-box RNA helicase AJ RNA processing and modification ; Translation, ribosomal structure and biogenesis ; IPR001650 [Helicase, C-terminal] ; IPR007502[Helicase-associated domain] ; IPR011545[DEAD/DEAH box helicase domain] ; IPR011709[Domain of unknown function DUF1605] -- -- A0A494B9D2 DNA polymerase alpha subunit B (Fragment) Pola2 138.7 131.9 129.4 106 110.2 104.2 1.24843945068664 0.0012967489770391 0.320125852253377 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Molecular Function:DNA-directed DNA polymerase activity (GO:0003887),Biological Process:DNA replication (GO:0006260) DNA polymerase alpha subunit B -- ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways ko03030 DNA replication DNA polymerase alpha-primase complex, polymerase-associated subunit B L Replication, recombination and repair ; IPR007185 [DNA polymerase alpha/epsilon, subunit B] ; IPR013627[DNA polymerase alpha, subunit B N-terminal] -- -- A0A286YDL1 Receptor-type tyrosine-protein phosphatase mu Ptprm 101.7 97.3 112.9 102.8 121.6 118.9 0.908534809204777 0.234489014965043 -0.138386304583105 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:membrane (GO:0016020) receptor-type tyrosine-protein phosphatase mu 3.1.3.48 ko04514 Cell adhesion molecules (CAMs) ko04520 Adherens junction Protein tyrosine phosphatase T Signal transduction mechanisms ; IPR000998 [MAM domain] ; IPR003961[Fibronectin type III] ; IPR013151[Immunoglobulin] -- -- Q7TSG1 Centrosomal protein of 120 kDa Cep120 34.7 26.9 35.7 32.8 27.2 28.5 1.09943502824859 0.418571053104171 0.136762349810752 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) centrosomal protein CEP120 -- -- -- -- -- IPR000008 [C2 domain] ; IPR022136[Domain of unknown function DUF3668] -- -- A0A1L1SUI3 Solute carrier family 37 (glucose-6-phosphate transporter), member 4 Slc37a4 158.9 190.5 273.1 220.8 219.7 203.8 0.966164830048114 0.843405771676104 -0.0496587575786256 Nonsignificant None 2 Cellular Component:integral component of membrane (GO:0016021),Biological Process:transmembrane transport (GO:0055085) MFS transporter, OPA family, solute carrier family 37 (glycerol-6-phosphate transporter), member 4 -- ko04973 Carbohydrate digestion and absorption Permease of the major facilitator superfamily G Carbohydrate transport and metabolism ; IPR011701 [Major facilitator superfamily] -- -- Q8CIG5 Vps8 protein Vps8 13 11.4 8.5 11.8 8.3 13 0.993957703927492 0.974090391991868 -0.00874363307197614 Nonsignificant None -- -- vacuolar protein sorting-associated protein 8 -- Vacuolar assembly/sorting protein VPS8 U Intracellular trafficking, secretion, and vesicular transport ; IPR025941 [Vacuolar protein sorting-associated protein 8, central domain] -- -- B7ZCT1 Regulator of G-protein-signaling 19 Rgs19 113 121.6 95.6 98.1 112.4 104.2 1.04925325707023 0.584454943540575 0.0693629416148341 Nonsignificant None -- -- regulator of G-protein signaling -- -- G protein signaling regulators T Signal transduction mechanisms ; IPR016137 [RGS domain] -- -- E9Q3I3 Spermatogenesis-associated protein 13 Spata13 171.9 178.1 190.4 191.7 200.6 198.3 0.915001693193363 0.0506759607296 -0.12815368180827 Nonsignificant None 3 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Molecular Function:protein binding (GO:0005515),Biological Process:regulation of Rho protein signal transduction (GO:0035023) Rho guanine nucleotide exchange factor 4/29 -- ko04810 Regulation of actin cytoskeleton Invasion-inducing protein TIAM1/CDC24 and related RhoGEF GTPases T Signal transduction mechanisms ; IPR000219 [Dbl homology (DH) domain] ; IPR001452[SH3 domain] ; IPR001849[Pleckstrin homology domain] -- -- Q3URK3 Methylcytosine dioxygenase TET1 Tet1 71.1 80.2 24.2 79.2 121.1 80.1 0.625891583452211 0.190055082140951 -0.6760153188187 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Molecular Function:zinc ion binding (GO:0008270) methylcytosine dioxygenase 1.14.11.- -- -- -- -- IPR002857 [Zinc finger, CXXC-type] ; IPR024779[2OGFeDO, oxygenase domain] -- -- Q91ZB0 Alpha-protein kinase 2 Alpk2 73.3 90.6 127.2 121.1 117.8 103.7 0.849678925861062 0.363625146441168 -0.235010311961233 Nonsignificant None 3 Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) alpha-kinase -- -- -- -- -- IPR004166 [MHCK/EF2 kinase] ; IPR013098[Immunoglobulin I-set] -- -- A3KMF2 Mkl2 protein (Fragment) Mrtfb 286.8 269.2 259.4 231 268.1 248.1 1.09127408993576 0.164686847192739 0.126013501778886 Nonsignificant None -- -- -- -- -- IPR003034 [SAP domain] ; IPR004018[RPEL repeat] -- -- Q9DC77 Small muscular protein Smpx 10.3 14.1 20.9 28.3 15.3 21.6 0.69478527607362 0.244700206606311 -0.525360914184843 Nonsignificant None -- -- -- -- -- -- -- -- IPR029268 [Small muscular protein Chisel] -- -- A0A5F8MPX7 RNA-binding motif, single-stranded-interacting protein 2 Rbms2 238.2 244.2 215.1 189.7 216.6 209.5 1.13267294576161 0.0853852845261435 0.179731349559095 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) -- -- -- FOG: RRM domain R General function prediction only ; IPR000504 [RNA recognition motif domain] -- -- A0A0J9YV20 Protein SDA1 Sdad1 15.3 11 9.6 14.9 15.3 16.5 0.768736616702355 0.113335833429462 -0.37943870588661 Nonsignificant None -- -- protein SDA1 -- -- Protein required for actin cytoskeleton organization and cell cycle progression DZ Cell cycle control, cell division, chromosome partitioning ; Cytoskeleton ; IPR007949 [SDA1 domain] ; IPR012977[Uncharacterised domain NUC130/133, N-terminal] -- -- Q3TXT3 SOSS complex subunit C Inip 20.2 18.6 23.9 24.6 35.3 33.4 0.672025723472669 0.0491069475335854 -0.57341163804972 Nonsignificant None 4 Cellular Component:nucleus (GO:0005634),Biological Process:DNA repair (GO:0006281),Biological Process:cellular response to DNA damage stimulus (GO:0006974),Cellular Component:SOSS complex (GO:0070876) -- -- -- -- -- -- IPR031821 [SOSS complex subunit C] -- -- Q3UMG6 Nucleoside diphosphate kinase 7 Nme7 179 193.7 178.3 186.8 172.4 187.3 1.00823421774931 0.84092513756109 0.0118308228992529 Nonsignificant None 5 Molecular Function:nucleoside diphosphate kinase activity (GO:0004550),Biological Process:nucleoside diphosphate phosphorylation (GO:0006165),Biological Process:GTP biosynthetic process (GO:0006183),Biological Process:UTP biosynthetic process (GO:0006228),Biological Process:CTP biosynthetic process (GO:0006241) nucleoside-diphosphate kinase 2.7.4.6 ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways Nucleoside diphosphate kinase F Nucleotide transport and metabolism ; IPR001564 [Nucleoside diphosphate kinase] ; IPR010554[Domain of unknown function DUF1126] -- -- Q5SPL2 PHD finger protein 12 Phf12 36.9 33.1 33.2 26 33.7 30.6 1.14285714285714 0.168647123389828 0.192645077942396 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- PHD Zn-finger protein R General function prediction only ; IPR019787 [Zinc finger, PHD-finger] ; IPR031966[PHD finger protein 12, MRG binding domain] -- -- Q8VHB5 Carbonic anhydrase 9 Ca9 265.1 273.7 237.1 260.9 285.2 271.5 0.948997064579256 0.348412522847991 -0.075524470152568 Nonsignificant None -- -- carbonic anhydrase 4.2.1.1 ko00910 Nitrogen metabolism Carbonic anhydrase R General function prediction only ; IPR001148 [Alpha carbonic anhydrase] -- -- P42581 Homeobox protein HMX3 Hmx3 225.3 188.3 173.6 148.6 452.3 176.5 0.755338307177772 0.581674742155414 -0.404805139495984 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) homeobox protein Nkx-5 -- -- Transcription factor NKX-5.1/HMX1, contains HOX domain K Transcription ; IPR001356 [Homeobox domain] -- Homeobox Q8BQS9 TGF-beta receptor type-2 Tgfbr2 352.4 337 335.2 320.1 274.5 298.5 1.1472399507334 0.037120907052188 0.198167169495371 Nonsignificant None 5 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468),Cellular Component:membrane (GO:0016020),Molecular Function:metal ion binding (GO:0046872) TGF-beta receptor type-2 2.7.11.30 ko04010 MAPK signaling pathway ko04060 Cytokine-cytokine receptor interaction ko04068 FoxO signaling pathway ko04144 Endocytosis ko04218 Cellular senescence ko04350 TGF-beta signaling pathway ko04380 Osteoclast differentiation ko04390 Hippo signaling pathway ko04520 Adherens junction ko04659 Th17 cell differentiation ko04926 Relaxin signaling pathway ko04933 AGE-RAGE signaling pathway in diabetic complications ko05142 Chagas disease (American trypanosomiasis) ko05166 HTLV-I infection ko05200 Pathways in cancer ko05202 Transcriptional misregulation in cancer ko05210 Colorectal cancer ko05212 Pancreatic cancer ko05220 Chronic myeloid leukemia ko05225 Hepatocellular carcinoma ko05226 Gastric cancer Transforming growth factor beta/activin receptor subfamily of serine/threonine kinases T Signal transduction mechanisms ; IPR001245 [Serine-threonine/tyrosine-protein kinase catalytic domain] ; IPR015013[Transforming growth factor beta receptor 2 ectodomain] -- -- A0A087WPM0 Selenoprotein H Selenoh 78.4 78.4 64 75.1 78.2 89.1 0.910891089108911 0.324061460179659 -0.134649526694782 Nonsignificant None -- -- -- -- -- -- -- -- IPR011893 [Selenoprotein, Rdx type] -- -- E9Q2B0 General transcription factor 3C polypeptide 4 Gtf3c4 24.1 17 14.6 13.4 13.8 14.8 1.32619047619048 0.248968343493524 0.407287999673909 Nonsignificant None -- -- general transcription factor 3C polypeptide 4 2.3.1.48 -- -- -- -- IPR024761 [Transcription factor IIIC, 90kDa subunit, N-terminal] ; IPR024764[Transcription factor IIIC, putative zinc-finger] -- -- Q7TN89 GTPase ERas Eras 35 30.7 80.5 80.2 80.8 75.7 0.617659484579637 0.197718227377201 -0.695116394782177 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) GTPase Eras -- -- Ras-related GTPase R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- A0A0G2JFB2 Tudor and KH domain-containing protein Tdrkh 24.6 16.7 15.1 20.6 25.6 26.2 0.779005524861878 0.195087277969245 -0.360294534684412 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) tudor domain-containing protein 2 -- -- Kinase anchor protein AKAP149, contains KH and Tudor RNA-binding domains T Signal transduction mechanisms ; IPR002999 [Tudor domain] ; IPR004088[K Homology domain, type 1] -- -- S4R1R1 G1/S-specific cyclin-D3 (Fragment) Ccnd3 1069.5 973 1229 565.2 705.5 560.2 1.78682615107324 0.00560396344970216 0.837399274454722 Significant up -- -- G1/S-specific cyclin-D3 -- ko04110 Cell cycle ko04115 p53 signaling pathway ko04151 PI3K-Akt signaling pathway ko04218 Cellular senescence ko04310 Wnt signaling pathway ko04390 Hippo signaling pathway ko04510 Focal adhesion ko04630 Jak-STAT signaling pathway ko05162 Measles ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis G1/S-specific cyclin D D Cell cycle control, cell division, chromosome partitioning ; IPR006671 [Cyclin, N-terminal] -- -- Q99N90 39S ribosomal protein L36, mitochondrial Mrpl36 130.7 126.8 120.3 141.9 130.6 148.8 0.896748160455732 0.0765839419742952 -0.157225214173885 Nonsignificant None 4 Molecular Function:structural constituent of ribosome (GO:0003735),Cellular Component:intracellular (GO:0005622),Cellular Component:ribosome (GO:0005840),Biological Process:translation (GO:0006412) large subunit ribosomal protein L36 -- ko03010 Ribosome Mitochondrial/chloroplast ribosomal protein L36 J Translation, ribosomal structure and biogenesis ; IPR000473 [Ribosomal protein L36] -- -- E9PU96 Nucleolar pre-ribosomal-associated protein 1 Urb1 30.7 26.4 28.6 26.9 20.6 23.5 1.20704225352113 0.0902400894571804 0.271476179720455 Nonsignificant None -- -- nucleolar pre-ribosomal-associated protein 1 -- -- Uncharacterized conserved protein S Function unknown ; IPR021714 [Nucleolar pre-ribosomal-associated protein 1, N-terminal] ; IPR032436[Nucleolar pre-ribosomal-associated protein 1, C-terminal domain] -- -- Q9D0L3 Cyclin-dependent kinases regulatory subunit Cks1b 142.4 160.5 123.6 145.9 159.7 118.9 1.00471142520612 0.968824580324085 0.00678118776525173 Nonsignificant None 2 Biological Process:cell cycle (GO:0007049),Molecular Function:cyclin-dependent protein serine/threonine kinase regulator activity (GO:0016538) cyclin-dependent kinase regulatory subunit CKS1 -- ko05200 Pathways in cancer ko05222 Small cell lung cancer Cyclin-dependent protein kinase CDC28, regulatory subunit CKS1, and related proteins D Cell cycle control, cell division, chromosome partitioning ; IPR000789 [Cyclin-dependent kinase, regulatory subunit] -- -- O70421 Frizzled-1 Fzd1 353.1 309.6 316.5 252.2 279.1 290 1.19225617922805 0.040050164322192 0.253694259954805 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Biological Process:cell surface receptor signaling pathway (GO:0007166),Cellular Component:membrane (GO:0016020) frizzled 1/7 -- ko04150 mTOR signaling pathway ko04310 Wnt signaling pathway ko04390 Hippo signaling pathway ko04550 Signaling pathways regulating pluripotency of stem cells ko04916 Melanogenesis ko05165 Human papillomavirus infection ko05166 HTLV-I infection ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05217 Basal cell carcinoma ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer Smoothened and related G-protein-coupled receptors T Signal transduction mechanisms ; IPR000539 [Frizzled protein] ; IPR020067[Frizzled domain] -- -- Q9WV35 C->U-editing enzyme APOBEC-2 Apobec2 156.4 167.7 154.4 168.1 228.9 225.8 0.768304431599229 0.0758831054059753 -0.380250019705649 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) C->U-editing enzyme APOBEC2 3.5.4.- -- -- -- -- IPR013158 [APOBEC-like, N-terminal] -- -- Q3U3C7 TFIID_NTD2 domain-containing protein (Fragment) Taf5l 31.5 19.2 17.6 18.3 17.3 21.1 1.20458553791887 0.441993986462193 0.268536843347861 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) transcription initiation factor TFIID subunit 5 -- ko03022 Basal transcription factors ko05168 Herpes simplex infection Transcription initiation factor TFIID, subunit TAF5 (also component of histone acetyltransferase SAGA) K Transcription ; IPR001680 [WD40 repeat] ; IPR007582[TFIID subunit TAF5, NTD2 domain] -- -- E9Q2Y9 Desumoylating isopeptidase 1 Desi1 83.8 62.5 64.8 50.7 65.9 62.4 1.17932960893855 0.260241971588889 0.237966991195537 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; -- -- -- Q91WU4 Transmembrane and coiled-coil domain-containing protein 4 Tmco4 52 56.7 61.5 62.9 63.5 61.1 0.907733333333333 0.111753238735228 -0.139659558584643 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR007941 [Protein of unknown function DUF726] -- -- Q3V3E1 Ubiquitin-associated and SH3 domain-containing protein A Ubash3a 80.1 82.5 84.6 85.3 78 92.9 0.964871194379391 0.540931210029718 -0.0515917324372722 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) ubiquitin-associated and SH3 domain-containing protein 3.1.3.48 -- Predicted phosphoglycerate mutase G Carbohydrate transport and metabolism ; IPR001452 [SH3 domain] ; IPR013078[Histidine phosphatase superfamily, clade-1] ; IPR015940[Ubiquitin-associated domain] -- -- M0QW72 Family with sequence similarity 71, member E2 Garin5b 298 265.3 309.6 357.2 360.5 372.7 0.800531914893617 0.00674131181584343 -0.320969174917935 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- E9QA62 Leiomodin-3 Lmod3 247.2 251.9 272 246.3 268.5 238 1.02430924548353 0.63421151939915 0.0346513399193836 Nonsignificant None 2 Molecular Function:tropomyosin binding (GO:0005523),Biological Process:pointed-end actin filament capping (GO:0051694) leiomodin -- -- Tropomodulin and leiomodulin Z Cytoskeleton ; IPR004934 [Tropomodulin] -- -- A0A1B0GQV2 Kelch-like protein 2 Klhl2 32.3 31 31 36.6 28.9 35.8 0.930898321816387 0.40045849424708 -0.103304498126042 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) kelch-like protein 2/3 -- -- Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes TR Signal transduction mechanisms ; General function prediction only ; IPR000210 [BTB/POZ domain] ; IPR006652[Kelch repeat type 1] ; IPR011705[BTB/Kelch-associated] -- ZBTB Q6GXA5 Matrix metalloproteinase 2 (Fragment) Mmp2 26.6 25.7 29.4 28.7 21.9 21 1.14106145251397 0.276442646777736 0.190376490881427 Nonsignificant None -- -- matrix metalloproteinase-2 (gelatinase A) 3.4.24.24 ko01522 Endocrine resistance ko04670 Leukocyte transendothelial migration ko04912 GnRH signaling pathway ko04915 Estrogen signaling pathway ko04926 Relaxin signaling pathway ko04933 AGE-RAGE signaling pathway in diabetic complications ko05200 Pathways in cancer ko05205 Proteoglycans in cancer ko05219 Bladder cancer ko05418 Fluid shear stress and atherosclerosis Gelatinase A and related matrix metalloproteases OW Posttranslational modification, protein turnover, chaperones ; Extracellular structures ; IPR018487 [Hemopexin-like repeats] -- -- P52793 Ephrin-A1 Efna1 19.3 19 18.4 30.5 19.3 25.3 0.754993342210386 0.197793033940084 -0.405464172572043 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) ephrin-A -- ko04010 MAPK signaling pathway ko04014 Ras signaling pathway ko04015 Rap1 signaling pathway ko04151 PI3K-Akt signaling pathway ko04360 Axon guidance Ephrin, ligand for Eph receptor tyrosine kinase T Signal transduction mechanisms ; IPR001799 [Ephrin receptor-binding domain] -- -- Q9D8X5 CCR4-NOT transcription complex subunit 8 Cnot8 139.5 150.3 153.9 124.2 133.4 128.3 1.14977973568282 0.0192184779301373 0.20135750927897 Nonsignificant None 2 Biological Process:nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289),Molecular Function:poly(A)-specific ribonuclease activity (GO:0004535) CCR4-NOT transcription complex subunit 7/8 -- ko03018 RNA degradation mRNA deadenylase subunit A RNA processing and modification ; IPR006941 [Ribonuclease CAF1] -- -- I7HPX9 UBX domain-containing protein 11 (Fragment) Ubxn11 152.9 150.4 195.6 214.9 225.2 213 0.76389526871842 0.0274575469016383 -0.388553238900937 Nonsignificant None -- -- -- -- -- Protein tyrosine phosphatase SHP1/Cofactor for p97 ATPase-mediated vesicle membrane fusion Y Nuclear structure ; -- -- -- A0A0J9YU82 StAR-related lipid transfer protein 13 Stard13 128.1 119.2 133 143.3 148.9 136.1 0.887929021713752 0.0432739268881311 -0.171483738260451 Nonsignificant None 2 Biological Process:signal transduction (GO:0007165),Molecular Function:lipid binding (GO:0008289) deleted in liver cancer protein -- -- Tumour suppressor protein p122-RhoGAP/DLC1 T Signal transduction mechanisms ; IPR000198 [Rho GTPase-activating protein domain] ; IPR002913[START domain] -- -- Q9ESG6 P2Y purinoceptor 14 P2ry14 824.6 858.1 634.1 351.1 425.4 383.1 1.99793032080028 0.00615339418263059 0.998506269021808 Significant up 3 Molecular Function:G-protein coupled receptor activity (GO:0004930),Biological Process:G-protein coupled receptor signaling pathway (GO:0007186),Cellular Component:integral component of membrane (GO:0016021) purinergic receptor P2Y, G protein-coupled, 14 -- ko04080 Neuroactive ligand-receptor interaction -- -- -- IPR000276 [G protein-coupled receptor, rhodopsin-like] -- -- Q3V340 Uncharacterized protein Adap2 8.5 11.9 11.3 10.6 9 5.6 1.25793650793651 0.297059460967305 0.331059106639491 Nonsignificant None 1 Molecular Function:GTPase activator activity (GO:0005096) -- -- -- Predicted GTPase-activating protein T Signal transduction mechanisms ; IPR001164 [Arf GTPase activating protein] ; IPR001849[Pleckstrin homology domain] -- -- Q8C5P3 Nitric oxide synthase Nos3 111.1 124.5 118.1 109.3 105.1 123.2 1.04768957345972 0.468002172354728 0.0672113149937336 Nonsignificant None 5 Molecular Function:nitric-oxide synthase activity (GO:0004517),Biological Process:nitric oxide biosynthetic process (GO:0006809),Molecular Function:FMN binding (GO:0010181),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) nitric-oxide synthase, endothelial 1.14.13.39 ko00220 Arginine biosynthesis ko00330 Arginine and proline metabolism ko01100 Metabolic pathways ko04020 Calcium signaling pathway ko04022 cGMP-PKG signaling pathway ko04066 HIF-1 signaling pathway ko04071 Sphingolipid signaling pathway ko04151 PI3K-Akt signaling pathway ko04370 VEGF signaling pathway ko04371 Apelin signaling pathway ko04611 Platelet activation ko04915 Estrogen signaling pathway ko04921 Oxytocin signaling pathway ko04926 Relaxin signaling pathway ko04931 Insulin resistance ko04933 AGE-RAGE signaling pathway in diabetic complications ko05418 Fluid shear stress and atherosclerosis NADP/FAD dependent oxidoreductase C Energy production and conversion ; IPR001433 [Oxidoreductase FAD/NAD(P)-binding] ; IPR003097[FAD-binding, type 1] ; IPR004030[Nitric oxide synthase, N-terminal] ; IPR008254[Flavodoxin/nitric oxide synthase] -- -- P47239 Paired box protein Pax-7 Pax7 155.6 167.1 36 235.1 250.1 153.4 0.561697463200752 0.144696067354937 -0.832134807612569 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) paired box protein 3/7 -- -- Transcription factor PRD and related proteins, contain PAX and HOX domains K Transcription ; IPR001356 [Homeobox domain] ; IPR001523[Paired domain] ; IPR022106[Paired box protein 7, C-terminal] -- PAX Q924W4 DNA-directed DNA/RNA polymerase mu DNAPOLmu 5.6 4.1 0 4.3 8.1 5.2 0.826704545454545 0.566230807664368 -0.274556275729013 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634),Molecular Function:DNA polymerase activity (GO:0034061) DNA polymerase mu 2.7.7.7 ko03450 Non-homologous end-joining DNA polymerase IV (family X) L Replication, recombination and repair ; IPR010996 [DNA polymerase beta-like, N-terminal domain] ; IPR018944[DNA polymerase lambda, fingers domain] ; IPR028207[DNA polymerase beta, palm domain] ; IPR029398[DNA polymerase beta, thumb domain] -- -- A2AQV0 Enhancer of polycomb homolog 2 (Fragment) Epc2 15.1 13.5 9.3 16.7 9.9 19.4 0.823913043478261 0.460884740772909 -0.279436012773284 Nonsignificant None -- -- enhancer of polycomb-like protein -- -- Polycomb enhancer protein, EPC K Transcription ; -- -- -- Q544C9 U6 snRNA-associated Sm-like protein LSm1 Lsm1 71.8 54.1 44.2 69 65.9 65.1 0.8505 0.341941369676156 -0.233616858998702 Nonsignificant None -- -- U6 snRNA-associated Sm-like protein LSm1 -- ko03018 RNA degradation Small Nuclear ribonucleoprotein splicing factor A RNA processing and modification ; IPR001163 [LSM domain, eukaryotic/archaea-type] -- -- A0A0G2JDH4 Krueppel-like factor 3 (Fragment) Klf3 72.5 72.5 84.9 91.8 70.3 75.6 0.967185527976441 0.75182508943955 -0.0481354372242546 Nonsignificant None -- -- krueppel-like factor 3 -- ko05202 Transcriptional misregulation in cancer FOG: Zn-finger R General function prediction only ; -- -- -- Q8BK45 FAM83 domain-containing protein Fam83g 74.8 65.4 62.9 68.8 66.4 86.5 0.916102841677943 0.44356198310453 -0.126418530571154 Nonsignificant None -- -- -- -- -- -- -- -- IPR012461 [Protein of unknown function DUF1669] -- -- G5E817 BTB/POZ domain-containing protein 6 Btbd6 64.3 51.4 49.7 63.9 63.5 67.1 0.850385604113111 0.110581996788161 -0.233810920702279 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) BTB/POZ domain-containing protein 3/6 -- -- Topoisomerase TOP1-interacting protein BTBD1 S Function unknown ; IPR000210 [BTB/POZ domain] ; IPR011705[BTB/Kelch-associated] ; IPR012983[PHR] -- ZBTB P70191 TNF receptor-associated factor 5 Traf5 31.7 26.6 15.7 17.7 22.8 27.7 1.08504398826979 0.74434791248632 0.11775353149214 Nonsignificant None 2 Molecular Function:zinc ion binding (GO:0008270),Molecular Function:metal ion binding (GO:0046872) TNF receptor-associated factor 5 -- ko04064 NF-kappa B signaling pathway ko04217 Necroptosis ko04621 NOD-like receptor signaling pathway ko04657 IL-17 signaling pathway ko04668 TNF signaling pathway ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05222 Small cell lung cancer TNF receptor-associated factor T Signal transduction mechanisms ; IPR001293 [Zinc finger, TRAF-type] ; IPR018957[Zinc finger, C3HC4 RING-type] -- -- Q8K2J7 RELT-like protein 1 Rell1 227.5 310.9 272.8 313 318.1 294.9 0.876025917926566 0.202225756441574 -0.190954541144259 Nonsignificant None -- -- -- -- -- -- -- -- IPR022248 [TNF receptor family, RELT] -- -- Q921Y2 U3 small nucleolar ribonucleoprotein protein IMP3 Imp3 166.8 182.4 164 182.4 176.1 139.8 1.02990166566326 0.748478613942793 0.0425065964061503 Nonsignificant None 3 Molecular Function:RNA binding (GO:0003723),Cellular Component:intracellular (GO:0005622),Molecular Function:rRNA binding (GO:0019843) U3 small nucleolar ribonucleoprotein protein IMP3 -- ko03008 Ribosome biogenesis in eukaryotes U3 small nucleolar ribonucleoprotein (snoRNP) component A RNA processing and modification ; IPR001912 [Ribosomal protein S4/S9, N-terminal] ; IPR002942[RNA-binding S4 domain] -- -- F6SDA4 Pecanex-like protein (Fragment) Pcnx3 85.8 92.1 109.6 91.8 105.6 109.5 0.936787227109808 0.508490466033074 -0.0942066897473849 Nonsignificant None -- -- -- -- -- Pecanex S Function unknown ; -- -- -- Q9CZ57 5-methylcytosine rRNA methyltransferase NSUN4 Nsun4 601.8 701.5 265.1 243 251 242.4 2.12982074959261 0.170419675101847 1.09073201516668 Nonsignificant None 1 Molecular Function:methyltransferase activity (GO:0008168) 5-methylcytosine rRNA methyltransferase NSUN4 2.1.1.- -- tRNA cytosine-5-methylases and related enzymes of the NOL1/NOP2/sun superfamily J Translation, ribosomal structure and biogenesis ; IPR001678 [SAM-dependent methyltransferase RsmB/NOP2-type] -- -- Q9DBV3 Probable ATP-dependent RNA helicase DHX34 Dhx34 226.3 275.6 76.1 122.5 154.6 237.7 1.12276612276612 0.775732475565585 0.16705743916734 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:helicase activity (GO:0004386),Molecular Function:ATP binding (GO:0005524) ATP-dependent RNA helicase DHX34 3.6.4.13 -- DEAH-box RNA helicase A RNA processing and modification ; IPR001650 [Helicase, C-terminal] ; IPR007502[Helicase-associated domain] ; IPR011545[DEAD/DEAH box helicase domain] ; IPR011709[Domain of unknown function DUF1605] -- -- Q3TAJ6 Gamma-tubulin complex component Tubgcp3 59.9 67.3 62.4 54.3 65.1 76.9 0.965868568517575 0.761693419353563 -0.0501012085679122 Nonsignificant None 5 Biological Process:microtubule cytoskeleton organization (GO:0000226),Cellular Component:spindle pole (GO:0000922),Cellular Component:microtubule organizing center (GO:0005815),Biological Process:microtubule nucleation (GO:0007020),Molecular Function:gamma-tubulin binding (GO:0043015) gamma-tubulin complex component 3 -- -- Gamma-tubulin complex, DGRIP91/SPC98 component Z Cytoskeleton ; IPR007259 [Gamma-tubulin complex component protein] -- -- Q9CQV4 Reticulophagy regulator 3 Retreg3 30.7 27.8 28.6 34.4 29.6 34.7 0.882472137791287 0.106816435717663 -0.180377365857533 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- A0A1W2P6E1 Actin-related protein 6 Actr6 13.1 14.4 14.6 16.5 18.2 17.6 0.804971319311663 0.00767719792029405 -0.312990713180545 Nonsignificant None -- -- actin-related protein 6 -- -- Actin-related protein - Arp6p Z Cytoskeleton ; IPR004000 [Actin family] -- -- A2AFS9 Testis-expressed 13A Tex13a 110.1 147.9 65.7 167.7 170.4 149.1 0.664408866995074 0.0918046355622328 -0.589856767697159 Nonsignificant None -- -- -- -- -- -- -- -- IPR028193 [Testis-expressed sequence 13 protein family] -- -- Q0VBM2 Protein FAM83B Fam83b 235.3 198.9 176.4 179.1 188.6 183.8 1.10716228467815 0.369650757866603 0.146866703728035 Nonsignificant None -- -- -- -- -- -- -- -- IPR012461 [Protein of unknown function DUF1669] -- -- Q9D8W4 Ig-like domain-containing protein Iglv1 234.5 207.3 259.6 226.3 271.8 221.1 0.975250278086763 0.801407629713796 -0.0361555902616349 Nonsignificant None -- -- immunoglobulin lambda-like polypeptide 1 -- -- -- -- -- IPR003597 [Immunoglobulin C1-set] -- -- Q62431 AT-rich interactive domain-containing protein 3A Arid3a 242 226.4 207.2 223.7 249.1 228.8 0.962941847206385 0.532653487214931 -0.0544794196433474 Nonsignificant None 1 Molecular Function:DNA binding (GO:0003677) -- -- -- DNA-binding proteins Bright/BRCAA1/RBP1 and related proteins containing BRIGHT domain K Transcription ; IPR001606 [ARID DNA-binding domain] -- ARID A0A0N4SVN7 FXYD domain-containing ion transport regulator Fxyd4 22.1 20.4 23.4 37.5 29.8 39.3 0.618198874296435 0.0111382252731602 -0.693857067751124 Significant down 3 Molecular Function:ion channel activity (GO:0005216),Biological Process:ion transport (GO:0006811),Cellular Component:membrane (GO:0016020) FXYD domain containing ion transport regulator 4 -- ko04960 Aldosterone-regulated sodium reabsorption -- -- -- IPR000272 [Ion-transport regulator, FXYD motif] -- -- Q566J8 Atypical kinase COQ8B, mitochondrial Coq8b 51.1 55.8 62.6 65.9 61.3 66.8 0.873711340206185 0.0948316833262886 -0.194771379050784 Nonsignificant None -- -- aarF domain-containing kinase -- -- ABC (ATP binding cassette) 1 protein R General function prediction only ; IPR004147 [UbiB domain] -- -- Q8VDZ4 Palmitoyltransferase ZDHHC5 Zdhhc5 282.2 325.9 237.4 210.4 180.7 177.1 1.48803238296374 0.0287284154588771 0.573405923107804 Nonsignificant None -- -- palmitoyltransferase ZDHHC5/8 2.3.1.225 -- DHHC-type Zn-finger proteins R General function prediction only ; IPR001594 [Palmitoyltransferase, DHHC domain] -- -- B1AWP8 Espin Espn 151.9 153.3 259.9 210.9 232 205.2 0.871933343619812 0.492723851055879 -0.197710244867714 Nonsignificant None 1 Molecular Function:actin binding (GO:0003779) -- -- -- FOG: Ankyrin repeat R General function prediction only ; IPR003124 [WH2 domain] -- -- Q9CQV3 Serpin B11 Serpinb11 589.5 638.8 696.8 610.4 636.8 668.2 1.00506421635168 0.931273021969066 0.00728768215284299 Nonsignificant None -- -- serpin B11/12 -- -- Serpin V Defense mechanisms ; IPR023796 [Serpin domain] -- -- G8JL54 COMM domain-containing protein 1 (Fragment) Commd1 192.2 161.3 133.8 159.2 179.8 175.2 0.947685725398678 0.644279774316209 -0.0775193876413404 Nonsignificant None -- -- -- -- -- -- -- -- IPR033776 [COMMD1 N-terminal domain] -- -- A0A0B4J1N3 Protein GPR15L Gpr15l 50.3 40.6 31 24.6 33.1 30.5 1.38208616780045 0.13996806742977 0.466847565062691 Nonsignificant None -- -- -- -- -- -- -- -- IPR031713 [Protein of unknown function DUF4725] -- -- E9Q1B2 TLC domain-containing protein 3A Tlcd3a 333.5 376.5 435.2 318.1 318.5 315.5 1.20281483037496 0.160502528870095 0.26641456116598 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) -- -- -- Uncharacterized conserved protein, contains TBC domain TR Signal transduction mechanisms ; General function prediction only ; IPR006634 [TRAM/LAG1/CLN8 homology domain] -- -- A2AIV2 Protein virilizer homolog Virma 42.7 42.2 42.9 42.1 48.4 44.9 0.943870014771049 0.298396075349773 -0.0833399026280022 Nonsignificant None -- -- -- -- -- Predicted nuclear membrane protein involved in mRNA transport and sex determination via splicing modulation AT RNA processing and modification ; Signal transduction mechanisms ; IPR031801 [Virilizer, N-terminal] -- -- A0A1B0GSS6 Predicted gene 3854 Gm3854 53.4 118.8 143.7 161.6 132.1 119.9 0.763781431334623 0.333514026334685 -0.388768248568062 Nonsignificant None 3 Molecular Function:nucleic acid binding (GO:0003676),Cellular Component:intracellular (GO:0005622),Molecular Function:metal ion binding (GO:0046872) KRAB domain-containing zinc finger protein -- -- FOG: Zn-finger R General function prediction only ; IPR001909 [Krueppel-associated box] ; IPR007087[Zinc finger, C2H2] -- zf-C2H2 Q5SSE9 ATP-binding cassette sub-family A member 13 Abca13 97.8 93.5 295.1 236.1 245.8 212.3 0.700662633246903 0.407208546160417 -0.513208136385061 Nonsignificant None 2 Molecular Function:ATP binding (GO:0005524),Molecular Function:ATPase activity (GO:0016887) ATP binding cassette, subfamily A (ABC1), member 13 -- ko02010 ABC transporters Lipid exporter ABCA1 and related proteins, ABC superfamily IR Lipid transport and metabolism ; General function prediction only ; IPR003439 [ABC transporter-like] -- -- Q9D8Z1 Activating signal cointegrator 1 complex subunit 1 Ascc1 24.4 17 25.3 26 26.9 25.9 0.846446700507614 0.263842659211098 -0.240508868271791 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) activating signal cointegrator complex subunit 1 -- -- Transcription coactivator complex, P50 component (LigT RNA ligase/phosphodiesterase family) K Transcription ; IPR004088 [K Homology domain, type 1] ; IPR019510[Protein kinase A anchor protein, nuclear localisation signal domain] -- -- Q3URN5 Uncharacterized protein Aatf 90.1 84.6 108.5 95.3 94 94.1 0.999294283697953 0.993482875807445 -0.00101849283502116 Nonsignificant None 1 Cellular Component:nucleus (GO:0005634) protein AATF/BFR2 -- -- Apoptosis antagonizing transcription factor/protein transport protein KU Transcription ; Intracellular trafficking, secretion, and vesicular transport ; IPR012617 [Apoptosis-antagonizing transcription factor, C-terminal] ; IPR025160[AATF leucine zipper-containing domain] -- -- Q8C7U1 NEDD4-binding protein 3 N4bp3 22.2 25.1 35.4 32.2 22.3 26.3 1.02351485148515 0.903988776834514 0.0335320364194798 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- A2A930 Histone-lysine N-methyltransferase PRDM16 Prdm16 773.9 720.3 747.6 625.4 657.3 699.3 1.13107971745711 0.0305200953246415 0.177700612729261 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) FOG: Zn-finger R General function prediction only ; IPR007087 [Zinc finger, C2H2] -- zf-C2H2 Q8C197 Glyco_transf_64 domain-containing protein Extl2 67 66.2 70.9 63.9 68.6 75.8 0.979836773883821 0.72802366746321 -0.0293866570079278 Nonsignificant None 3 Biological Process:glycosaminoglycan biosynthetic process (GO:0006024),Biological Process:heparan sulfate proteoglycan biosynthetic process (GO:0015012),Cellular Component:integral component of membrane (GO:0016021) alpha-1,4-N-acetylglucosaminyltransferase EXTL2 2.4.1.223 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin ko01100 Metabolic pathways Acetylglucosaminyltransferase EXT2/exostosin 2 GMW Carbohydrate transport and metabolism ; Cell wall/membrane/envelope biogenesis ; Extracellular structures ; IPR015338 [Exostosin , C-terminal] -- -- Q5M8N3 Sorting nexin 7 Snx7 294.6 268.6 354.7 295.5 281.9 284.6 1.06484918793504 0.510634717923547 0.090649119441839 Nonsignificant None 1 Molecular Function:phosphatidylinositol binding (GO:0035091) sorting nexin-7/30 -- -- Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins U Intracellular trafficking, secretion, and vesicular transport ; IPR001683 [Phox homologous domain] -- -- P97326 Cadherin-6 Cdh6 14.4 13.2 9.1 7.3 17.5 20.2 0.815555555555555 0.549951941034446 -0.294144938373824 Nonsignificant None 3 Molecular Function:calcium ion binding (GO:0005509),Biological Process:homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156),Cellular Component:membrane (GO:0016020) cadherin 6, type 2, K-cadherin -- -- FOG: Cadherin repeats S Function unknown ; IPR000233 [Cadherin, cytoplasmic domain] ; IPR002126[Cadherin] -- -- A0A0G2JH06 Histone-lysine N-methyltransferase SETD2 (Fragment) Setd2 73.8 69 62.6 66.1 74.7 61.4 1.01582591493571 0.843596277562939 0.0226531844151804 Nonsignificant None -- -- histone-lysine N-methyltransferase SETD2 2.1.1.43 ko00310 Lysine degradation Clathrin coat binding protein/Huntingtin interacting protein HIP1, involved in regulation of endocytosis U Intracellular trafficking, secretion, and vesicular transport ; -- -- -- Q9DAZ9 Abscission/NoCut checkpoint regulator Zfyve19 169.1 236.1 209.9 250.3 230.7 213.2 0.886055891673869 0.301504359877161 -0.174530389225036 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) -- -- -- Membrane trafficking and cell signaling protein HRS, contains VHS and FYVE domains TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR000306 [FYVE zinc finger] -- -- H3BLI8 WD repeat domain 17 Wdr17 567.8 519.9 620.7 520.8 539.7 516.1 1.08359761512115 0.216807615557195 0.115829123443373 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- -- -- -- IPR001680 [WD40 repeat] -- -- A0A0G2JEY4 RIKEN cDNA 3110082I17 gene 3110082I17Rik 225.9 256.8 281.9 217.8 227.6 213.4 1.16059502125076 0.102717926361053 0.214864645108294 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019327 [Protein of unknown function DUF2373] -- -- F7CFT1 AN1-type zinc finger protein 1 (Fragment) Zfand1 103.5 100.8 87.6 99.7 97.9 109.7 0.949886104783599 0.449613686026031 -0.0741735560906947 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) -- -- -- Predicted Zn-finger protein R General function prediction only ; IPR000058 [Zinc finger, AN1-type] -- -- Q810J8 Zinc finger FYVE domain-containing protein 1 Zfyve1 79.7 83.4 91.5 101.2 86.5 86.7 0.927842565597668 0.332068791333675 -0.108048062271454 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) zinc finger FYVE domain-containing protein 1 -- ko04140 Autophagy - animal Membrane trafficking and cell signaling protein HRS, contains VHS and FYVE domains TU Signal transduction mechanisms ; Intracellular trafficking, secretion, and vesicular transport ; IPR000306 [FYVE zinc finger] -- -- B2RS24 Occludin Ocln 181.2 182.5 222.3 282.1 324.2 279.9 0.661250282103363 0.00713544336651329 -0.596731662176335 Significant down 1 Cellular Component:membrane (GO:0016020) occludin -- ko04514 Cell adhesion molecules (CAMs) ko04530 Tight junction ko04670 Leukocyte transendothelial migration ko05160 Hepatitis C -- -- -- IPR008253 [Marvel domain] ; IPR010844[Occludin homology domain] -- -- Q9CZP7 Hsp90 co-chaperone Cdc37-like 1 Cdc37l1 117.5 131.2 165.4 151.8 161.7 144.6 0.903951102379393 0.385866226299784 -0.145683360148129 Nonsignificant None -- -- -- -- -- Cell division cycle 37 protein, CDC37 D Cell cycle control, cell division, chromosome partitioning ; IPR013874 [Cdc37, Hsp90 binding] -- -- Q921Y4 Molybdate-anion transporter Mfsd5 59.8 53.9 55.2 70 54.1 74.5 0.850453172205438 0.1991293869562 -0.233696294726988 Nonsignificant None 3 Molecular Function:molybdate ion transmembrane transporter activity (GO:0015098),Biological Process:molybdate ion transport (GO:0015689),Cellular Component:integral component of membrane (GO:0016021) -- -- -- Predicted sugar transporter G Carbohydrate transport and metabolism ; IPR008509 [Molybdate-anion transporter] -- -- V9H0W7 Pro-Pol-dUTPase polyprotein (Fragment) pro-pol-dUTPase 112.6 88.3 548.4 471.6 524.4 500.2 0.500802031813929 0.236854454401731 -0.997687679418084 Nonsignificant None 5 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:RNA-DNA hybrid ribonuclease activity (GO:0004523),Biological Process:DNA integration (GO:0015074),Molecular Function:hydrolase activity (GO:0016787),Biological Process:dUTP metabolic process (GO:0046080) -- -- -- dUTPase F Nucleotide transport and metabolism ; IPR000477 [Reverse transcriptase domain] ; IPR001584[Integrase, catalytic core] ; IPR002156[Ribonuclease H domain] ; IPR008180[Deoxyuridine triphosphate nucleotidohydrolase/Deoxycytidine triphosphate deaminase] -- -- Q3UX43 Ankyrin repeat domain-containing protein 13C Ankrd13c 31.8 28.7 26.7 29.3 30.9 28.4 0.984198645598194 0.791823475317964 -0.0229785637780919 Nonsignificant None -- -- ankyrin repeat domain-containing protein 13 -- -- Ankyrin repeat protein R General function prediction only ; IPR020683 [Ankyrin repeat-containing domain] ; IPR021832[Ankyrin repeat domain-containing protein 13] -- -- D3Z0H9 Translation initiation factor IF-3, mitochondrial (Fragment) Mtif3 225.7 205.6 222.3 254.4 236.8 241.3 0.892286689419795 0.0320863676843185 -0.164420776051289 Nonsignificant None 2 Molecular Function:translation initiation factor activity (GO:0003743),Biological Process:translational initiation (GO:0006413) translation initiation factor IF-3 -- -- -- -- -- IPR019814 [Translation initiation factor 3, N-terminal] -- -- Q9CR64 Protein kish-A Tmem167a 34.8 39.3 23.1 35.6 36.1 38.1 0.885245901639344 0.477011785761039 -0.175849835399418 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR009653 [Protein kish] -- -- J3QNN4 Ankyrin repeat domain 66 Ankrd66 158.8 140.3 149.5 160.6 148.5 151.3 0.974370112945265 0.576208291374128 -0.0374582130459581 Nonsignificant None -- -- -- -- -- FOG: Ankyrin repeat R General function prediction only ; IPR020683 [Ankyrin repeat-containing domain] -- -- P86044 Anoctamin-9 Ano9 244.4 218.2 213.5 224.1 222.1 234.2 0.993680188124633 0.8962153838544 -0.00914649385135328 Nonsignificant None -- -- anoctamin-9 -- -- Uncharacterized conserved protein S Function unknown ; IPR007632 [Anoctamin] -- -- A2AKY4 Zinc finger protein 804A Znf804a 239.9 226.6 106.1 344.2 466.8 242.8 0.543366862782312 0.107241198233414 -0.880001509374124 Nonsignificant None -- -- -- -- -- -- -- -- IPR022755 [Zinc finger, double-stranded RNA binding] -- -- A6PWX1 Calcium channel flower homolog Cacfd1 114.6 89.3 111 111.7 117.6 107.7 0.934421364985163 0.430455645872517 -0.0978548339338109 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019365 [TVP18/Calcium channel flower] -- -- Q5XFZ0 UPF0711 protein C18orf21 homolog 16.9 16.5 21.2 18.3 19.1 19.5 0.959578207381371 0.645816670252374 -0.0595277013867297 Nonsignificant None -- -- -- -- -- -- -- -- IPR029779 [Protein of unknown function DUF4674] -- -- Q9Z0I4 Schlafen4 (Fragment) Slfn4 406.4 406.8 495.4 459.8 434.8 451.4 0.97221396731055 0.703646213279533 -0.0406542341357727 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) -- -- -- -- -- -- IPR007421 [Schlafen, AAA domain] -- -- E9PZM7 SR-related CTD-associated factor 11 Scaf11 111.8 115.7 84.1 69.8 80.8 80.1 1.35067186822713 0.0631194467947329 0.433677229378687 Nonsignificant None -- -- -- -- -- PHD Zn-finger protein R General function prediction only ; -- -- -- A0A0R4J0I4 Chromosome transmission fidelity protein 18 homolog Chtf18 102.8 99.5 195.6 81.6 88.5 92.9 1.51292775665399 0.288996978639053 0.597343099514073 Nonsignificant None 1 Molecular Function:ATP binding (GO:0005524) chromosome transmission fidelity protein 18 -- -- DNA replication checkpoint protein CHL12/CTF18 DL Cell cycle control, cell division, chromosome partitioning ; Replication, recombination and repair ; IPR003959 [ATPase, AAA-type, core] -- -- B2RUK8 Kelch domain containing 9 Klhdc9 129.2 174.2 109.1 84.3 88.7 96.1 1.53288740245262 0.0708346742693536 0.616251728380123 Nonsignificant None -- -- -- -- -- Kelch repeat-containing proteins R General function prediction only ; -- -- -- A6P3E3 Nuclear receptor coactivator Ncoa2 8.5 7.8 11.5 11.6 10.7 7.3 0.939189189189189 0.746578666272252 -0.0905122929054426 Nonsignificant None 3 Molecular Function:transcription coactivator activity (GO:0003713),Cellular Component:nucleus (GO:0005634),Molecular Function:nuclear hormone receptor binding (GO:0035257) nuclear receptor coactivator 2 -- ko04919 Thyroid hormone signaling pathway Aryl-hydrocarbon receptor nuclear translocator K Transcription ; IPR010011 [Domain of unknown function DUF1518] ; IPR013767[PAS fold] ; IPR014920[Nuclear receptor coactivator, Ncoa-type, interlocking] ; IPR014935[Nuclear receptor coactivator, receptor-binding domain] ; IPR032565[Domain of unknown function DUF4927] -- -- E9PWU7 Kinesin-like protein Kifc3 8.3 4.5 12.1 9.8 7.7 8.7 0.950381679389313 0.858286435024194 -0.0734210694693694 Nonsignificant None 4 Molecular Function:microtubule motor activity (GO:0003777),Molecular Function:ATP binding (GO:0005524),Biological Process:microtubule-based movement (GO:0007018),Molecular Function:microtubule binding (GO:0008017) kinesin family member C2/C3 -- -- Kinesin (KAR3 subfamily) Z Cytoskeleton ; IPR001752 [Kinesin motor domain] -- -- Q8BKT3 Intron Large complex component GCFC2 Gcfc2 78.3 90.8 96.2 85.1 91.3 91.3 0.991034740381024 0.894977629053746 -0.0129924634120819 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Cellular Component:nucleus (GO:0005634) GC-rich sequence DNA-binding factor -- -- Transcriptional regulators binding to the GC-rich sequences K Transcription ; IPR022783 [GC-rich sequence DNA-binding factor domain] -- -- A2APY7 Arginine-hydroxylase NDUFAF5, mitochondrial Ndufaf5 149.5 139.7 159.4 210 176.5 189 0.779496090356212 0.0201080717821667 -0.359386307933321 Nonsignificant None 2 Biological Process:metabolic process (GO:0008152),Molecular Function:methyltransferase activity (GO:0008168) NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 2.1.1.- -- Predicted methyltransferase R General function prediction only ; IPR013216 [Methyltransferase type 11] -- -- Q8CC21 Tetratricopeptide repeat protein 19, mitochondrial Ttc19 125.2 131.6 136 169.1 174.8 182 0.746910058946568 0.000808149263801266 -0.420993567166001 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) tetratricopeptide repeat protein 19, mitochondrial -- -- Kinesin light chain Z Cytoskeleton ; IPR011990 [Tetratricopeptide-like helical domain] -- -- Q3UUD2 Protein sprouty homolog 3 Spry3 177.1 208 140.4 366.8 397.3 256.6 0.514842754972078 0.0246066630650921 -0.957796228149025 Significant down 3 Biological Process:multicellular organism development (GO:0007275),Biological Process:regulation of signal transduction (GO:0009966),Cellular Component:membrane (GO:0016020) protein sprouty homolog 3 -- -- -- -- -- IPR007875 [Sprouty] -- -- Q60738 Zinc transporter 1 Slc30a1 77.8 71.3 90.1 78.4 84.6 78 0.99253112033195 0.924047035223175 -0.0108157569192189 Nonsignificant None 4 Biological Process:cation transport (GO:0006812),Molecular Function:cation transmembrane transporter activity (GO:0008324),Cellular Component:integral component of membrane (GO:0016021),Biological Process:transmembrane transport (GO:0055085) solute carrier family 30 (zinc transporter), member 1 -- ko04978 Mineral absorption Zn2+ transporter ZNT1 and related Cd2+/Zn2+ transporters (cation diffusion facilitator superfamily) P Inorganic ion transport and metabolism ; IPR002524 [Cation efflux protein] -- -- Q80XK2 Bromodomain and PHD finger containing, 1 Brpf1 151.7 244.1 224.5 447.4 422.3 313.4 0.52430056630885 0.019673091874317 -0.931533990744848 Significant down 1 Molecular Function:protein binding (GO:0005515) bromodomain and PHD finger-containing protein 1 -- -- PHD finger protein BR140/LIN-49 R General function prediction only ; IPR000313 [PWWP domain] ; IPR001487[Bromodomain] ; IPR019542[Enhancer of polycomb-like, N-terminal] -- -- Q69ZU8 Ankyrin repeat domain-containing protein 6 Ankrd6 109.6 108.4 107.7 154.7 136.5 174.6 0.699227136109918 0.0509384075881747 -0.516166919814963 Nonsignificant None -- -- ankyrin repeat domain-containing protein 6 -- -- FOG: Ankyrin repeat R General function prediction only ; IPR020683 [Ankyrin repeat-containing domain] -- -- Q3UGM4 Anion exchange protein (Fragment) Slc4a2 16 13.9 16.8 14.2 12.9 16.1 1.08101851851852 0.410031170160288 0.112391237546193 Nonsignificant None 3 Biological Process:anion transport (GO:0006820),Molecular Function:anion transmembrane transporter activity (GO:0008509),Cellular Component:integral component of membrane (GO:0016021) solute carrier family 4 (anion exchanger), member 2 -- ko04970 Salivary secretion ko04971 Gastric acid secretion ko04972 Pancreatic secretion ko04976 Bile secretion Na+-independent Cl/HCO3 exchanger AE1 and related transporters (SLC4 family) P Inorganic ion transport and metabolism ; IPR011531 [Bicarbonate transporter, C-terminal] ; IPR013769[Band 3 cytoplasmic domain] -- -- Q5RJH2 Multiple C2 and transmembrane domain-containing protein 2 Mctp2 83.2 74 73.1 73.5 83.5 83.9 0.955998339559983 0.493062999583796 -0.0649199824456251 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Predicted Ca2+-dependent phospholipid-binding protein R General function prediction only ; IPR000008 [C2 domain] ; IPR013583[Phosphoribosyltransferase C-terminal] -- -- Q3TAC0 BCAS3 domain-containing protein (Fragment) Bcas3 82.6 67.7 80.2 86.1 85.9 88.1 0.886197616301422 0.163440587118466 -0.174299648626291 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR022175 [Breast carcinoma amplified sequence 3] -- -- Q9JJN6 Beta-catenin-interacting protein 1 Ctnnbip1 147.7 107.5 100 159.4 159.2 192.3 0.6952436876101 0.0481512367808385 -0.524409354049593 Nonsignificant None 1 Molecular Function:beta-catenin binding (GO:0008013) Beta-catenin-interacting protein 1 (Inhibitor of beta-catenin and Tcf-4) -- ko04310 Wnt signaling pathway -- -- -- IPR009428 [Beta-catenin-interacting ICAT] -- -- Q8C050 Ribosomal protein S6 kinase alpha-5 Rps6ka5 240.1 249.2 292.6 385.3 365.4 320.7 0.729792794474519 0.018253080415088 -0.454441188178721 Nonsignificant None 4 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:protein serine/threonine kinase activity (GO:0004674),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) ribosomal protein S6 kinase alpha-5 2.7.11.1 ko04010 MAPK signaling pathway ko04261 Adrenergic signaling in cardiomyocytes ko04668 TNF signaling pathway ko04713 Circadian entrainment ko04722 Neurotrophin signaling pathway ko05200 Pathways in cancer ko05206 MicroRNAs in cancer ko05219 Bladder cancer Ribosomal protein S6 kinase T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] ; IPR017892[Protein kinase, C-terminal] -- -- A0A1W2P6W7 Serine/threonine-protein kinase TBK1 Tbk1 103.5 90.4 90.9 85.1 84.6 91.4 1.09076981999234 0.175992077593368 0.125346688653556 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) TANK-binding kinase 1 2.7.11.10 ko04014 Ras signaling pathway ko04137 Mitophagy - animal ko04620 Toll-like receptor signaling pathway ko04621 NOD-like receptor signaling pathway ko04622 RIG-I-like receptor signaling pathway ko04623 Cytosolic DNA-sensing pathway ko04657 IL-17 signaling pathway ko05160 Hepatitis C ko05161 Hepatitis B ko05162 Measles ko05164 Influenza A ko05165 Human papillomavirus infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection TANK binding protein kinase TBK1 T Signal transduction mechanisms ; IPR000719 [Protein kinase domain] -- -- O88822 Lathosterol oxidase Sc5d 109.1 104.3 129.7 150 166.9 188.2 0.679271431399723 0.0162168624308605 -0.557939915873548 Nonsignificant None 4 Molecular Function:iron ion binding (GO:0005506),Biological Process:fatty acid biosynthetic process (GO:0006633),Molecular Function:oxidoreductase activity (GO:0016491),Biological Process:oxidation-reduction process (GO:0055114) Delta7-sterol 5-desaturase 1.14.19.20 ko00100 Steroid biosynthesis ko01100 Metabolic pathways Sterol C5 desaturase I Lipid transport and metabolism ; IPR006694 [Fatty acid hydroxylase] -- -- Q9CY62 E3 ubiquitin-protein ligase RNF181 Rnf181 92.1 103.2 97 101.8 96.4 98.5 0.985170205594877 0.702682167046206 -0.0215550976742143 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:zinc ion binding (GO:0008270) FOG: Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR001841 [Zinc finger, RING-type] -- -- D3Z3C6 AN1-type zinc finger protein 4 Zfand4 234.7 209.1 321.7 370.4 431.1 349.2 0.665247240809942 0.0377506713437018 -0.588037473372402 Significant down 2 Molecular Function:protein binding (GO:0005515),Molecular Function:zinc ion binding (GO:0008270) AN1-type zinc finger and ubiquitin domain-containing protein 1 -- -- Ubiquitin and ubiquitin-like proteins OR Posttranslational modification, protein turnover, chaperones ; General function prediction only ; IPR000058 [Zinc finger, AN1-type] ; IPR000626[Ubiquitin domain] -- -- A0A0R4J0T1 Poly [ADP-ribose] polymerase Parp6 295.5 308.5 286.6 368 290.5 353.7 0.879865639201739 0.175379887794273 -0.184644862565818 Nonsignificant None 1 Molecular Function:NAD+ ADP-ribosyltransferase activity (GO:0003950) poly [ADP-ribose] polymerase 6/8 2.4.2.30 -- -- -- -- IPR012317 [Poly(ADP-ribose) polymerase, catalytic domain] -- -- Q99LX3 Cyp27a1 protein Cyp27a1 75.3 111.1 107.2 167.3 145 141.6 0.646838510685173 0.018446895915886 -0.628522520094681 Significant down 3 Molecular Function:iron ion binding (GO:0005506),Molecular Function:heme binding (GO:0020037),Biological Process:oxidation-reduction process (GO:0055114) cholestanetriol 26-monooxygenase 1.14.15.15 ko00120 Primary bile acid biosynthesis ko01100 Metabolic pathways ko03320 PPAR signaling pathway ko04979 Cholesterol metabolism Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Q Secondary metabolites biosynthesis, transport and catabolism ; IPR001128 [Cytochrome P450] -- -- Q3U0J7 Vitamin D3 receptor Vdr 271 256.6 341.5 275.8 285.4 262.1 1.05562978258229 0.603135137853311 0.0781039592418165 Nonsignificant None 4 Cellular Component:nucleus (GO:0005634),Molecular Function:zinc ion binding (GO:0008270),Biological Process:steroid hormone mediated signaling pathway (GO:0043401),Molecular Function:sequence-specific DNA binding (GO:0043565) vitamin D3 receptor -- ko04961 Endocrine and other factor-regulated calcium reabsorption ko04978 Mineral absorption ko05152 Tuberculosis FOG: Hormone receptors T Signal transduction mechanisms ; IPR000536 [Nuclear hormone receptor, ligand-binding domain] ; IPR001628[Zinc finger, nuclear hormone receptor-type] -- THR-like Q8C4Q6 Axin interactor, dorsalization-associated protein Aida 40.1 42.5 45.6 51.7 52.4 48.2 0.841759684832567 0.0174006465137009 -0.248519679868551 Nonsignificant None -- -- -- -- -- -- -- -- IPR023421 [Axin interactor, dorsalization-associated protein, N-terminal] ; IPR025939[Axin interactor dorsalization-associated protein, C-terminal domain] -- -- Q9ER97 Neuroglobin Ngb 37.2 32.8 31.3 36.4 40.1 42 0.854852320675105 0.0765768848895049 -0.226252884984483 Nonsignificant None 2 Molecular Function:oxygen binding (GO:0019825),Molecular Function:heme binding (GO:0020037) neuroglobin -- -- Globins and related hemoproteins C Energy production and conversion ; IPR000971 [Globin] -- -- Q9D8B7 Junctional adhesion molecule C Jam3 55.4 53.9 58.8 69.4 64 64.3 0.850278199291856 0.0122636482947201 -0.233993146493041 Nonsignificant None -- -- junctional adhesion molecule 3 -- ko04514 Cell adhesion molecules (CAMs) ko04530 Tight junction ko04670 Leukocyte transendothelial migration -- -- -- IPR013106 [Immunoglobulin V-set domain] -- -- Q8VF06 Olfactory receptor Olfr677 203.3 214.1 154.1 156.1 131.2 139.9 1.3377808988764 0.072554165183409 0.419841851414287 Nonsignificant None -- -- olfactory receptor -- ko04740 Olfactory transduction -- -- -- -- -- -- Q6NS45 Coiled-coil domain-containing protein 66 Ccdc66 103.8 120 52.8 140.2 181.6 111.4 0.638504155124654 0.143321560112303 -0.647232086457833 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q3UDU6 Rab-GAP TBC domain-containing protein Tbc1d17 109.1 112.7 129.7 111.7 125.5 108.5 1.01677755279144 0.825588622187214 0.0240040856974989 Nonsignificant None -- -- TBC1 domain family member 17 -- ko04137 Mitophagy - animal Ypt/Rab-specific GTPase-activating protein GYP7 and related proteins T Signal transduction mechanisms ; IPR000195 [Rab-GTPase-TBC domain] ; IPR021935[Domain of unknown function DUF3548] -- -- Q9DCS1 Transmembrane protein 176A Tmem176a 7.3 5.7 0 6.3 7.4 2.8 1.18181818181818 0.632883850489188 0.241008099503795 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) -- -- -- -- -- -- IPR007237 [CD20-like family] -- -- Q8K119 PMS1 homolog 1, mismatch repair system component Pms1 134.7 72.7 132.4 152.6 201.3 109.1 0.733909287257019 0.287254386004006 -0.446326340963378 Nonsignificant None 3 Molecular Function:ATP binding (GO:0005524),Biological Process:mismatch repair (GO:0006298),Molecular Function:mismatched DNA binding (GO:0030983) DNA mismatch repair protein PMS1 -- -- DNA mismatch repair protein - MLH2/PMS1/Pms2 family L Replication, recombination and repair ; IPR009071 [High mobility group box domain] ; IPR013507[DNA mismatch repair protein, C-terminal] -- HMG Q148S3 RNA-binding protein NOB1 Nob1 292.7 300.7 334.1 376.7 332.7 323 0.898392096086788 0.168460551069826 -0.154582859698442 Nonsignificant None -- -- RNA-binding protein NOB1 -- ko03008 Ribosome biogenesis in eukaryotes Predicted RNA-binding protein Nob1p involved in 26S proteasome assembly O Posttranslational modification, protein turnover, chaperones ; IPR014881 [Nin one binding (NOB1) Zn-ribbon-like] ; IPR033411[Ribonuclease, PIN domain] ; IPR033461[Putative WW-binding domain and destruction box] -- -- Q9ES83 Blood vessel epicardial substance Bves 33.5 37.2 41.8 48.4 35.9 41.3 0.895700636942675 0.371599591508984 -0.158911462787228 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) blood vessel epicardial substance -- ko04530 Tight junction -- -- -- IPR006916 [Popeye protein] -- -- Q3UJD1 Uncharacterized protein Mrtfb 243 238.3 246.2 118.9 124.9 109.7 2.05799151343706 0.0000151177089560406 1.04123703298625 Significant up -- -- -- -- -- -- -- -- -- -- -- Q3UHM2 TNF receptor-associated factor Traf3 83.5 81.8 18.4 20.2 16.6 25.9 2.92982456140351 0.198789909557545 1.55081427830931 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) TNF receptor-associated factor 3 -- ko04064 NF-kappa B signaling pathway ko04620 Toll-like receptor signaling pathway ko04621 NOD-like receptor signaling pathway ko04622 RIG-I-like receptor signaling pathway ko04657 IL-17 signaling pathway ko04668 TNF signaling pathway ko05160 Hepatitis C ko05165 Human papillomavirus infection ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05168 Herpes simplex infection ko05169 Epstein-Barr virus infection ko05200 Pathways in cancer ko05203 Viral carcinogenesis ko05222 Small cell lung cancer TNF receptor-associated factor T Signal transduction mechanisms ; IPR001293 [Zinc finger, TRAF-type] -- -- A0A1B0GSJ7 Fibronectin type 3 and ankyrin repeat domains 1 protein Fank1 284.4 260.1 309.4 333.4 349.2 367.1 0.813470515385348 0.0193499281131337 -0.297838039190203 Nonsignificant None -- -- -- -- -- FOG: Ankyrin repeat R General function prediction only ; IPR020683 [Ankyrin repeat-containing domain] -- -- Q76M80 MNTK1 Kcnk12 95.2 100.7 79.1 97.1 116.5 110.7 0.847980265186556 0.13071005797565 -0.237897405156422 Nonsignificant None -- -- potassium channel subfamily K member 12 -- -- Tandem pore domain K+ channel TASK3/THIK-1 P Inorganic ion transport and metabolism ; IPR013099 [Potassium channel domain] -- -- A0A0A0MQ89 Actin-related protein 5 Actr5 39.1 30.1 29.4 25 28.7 31.9 1.1518691588785 0.307132080502183 0.203976849976765 Nonsignificant None -- -- actin-related protein 5 -- -- Actin-related protein - Arp5p Z Cytoskeleton ; IPR004000 [Actin family] -- -- Q8BNW9 Kelch repeat and BTB domain-containing protein 11 Kbtbd11 77.9 74 63.7 93.6 91.8 76.6 0.822900763358779 0.0870888181734074 -0.281209633672307 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) kelch repeat and BTB domain-containing protein 11 -- -- FOG: Kelch repeat R General function prediction only ; IPR000210 [BTB/POZ domain] ; IPR006652[Kelch repeat type 1] -- ZBTB Q7TT34 Amyloid beta (A4)-like protein 2 Aplp2 56.7 85.4 104.7 125 115.7 79.8 0.770046801872075 0.278431202043439 -0.376981962356686 Nonsignificant None 2 Molecular Function:heparin binding (GO:0008201),Molecular Function:transition metal ion binding (GO:0046914) amyloid-like protein 2 -- -- Beta amyloid precursor protein R General function prediction only ; IPR011178 [Amyloidogenic glycoprotein, copper-binding] ; IPR015849[Amyloidogenic glycoprotein, heparin-binding] ; IPR019543[Beta-amyloid precursor protein C-terminal] ; IPR024329[Amyloidogenic glycoprotein, E2 domain] -- -- Q4V9Z5 Seizure 6-like protein 2 Sez6l2 58.3 51 52.2 51.5 54.8 50.8 1.02800763844685 0.599379707864685 0.0398509842870911 Nonsignificant None -- -- -- -- -- -- -- -- IPR000436 [Sushi/SCR/CCP domain] ; IPR000859[CUB domain] -- -- Q4FJM4 Inhibin beta A chain Inhba 46.7 62.1 10.2 128 124.6 77 0.361043689320388 0.03569619739853 -1.46975466898791 Significant down 2 Molecular Function:growth factor activity (GO:0008083),Biological Process:growth (GO:0040007) inhibin, beta -- ko04350 TGF-beta signaling pathway ko04550 Signaling pathways regulating pluripotency of stem cells Transforming growth factor beta, bone morphogenetic protein and related proteins T Signal transduction mechanisms ; IPR001111 [Transforming growth factor-beta, N-terminal] ; IPR001839[Transforming growth factor-beta, C-terminal] -- -- Q9EPN8 Olfactory receptor Olfr631 335.7 324.6 276.1 231.6 232.4 234.7 1.3402032345785 0.0490851219115192 0.42245179417999 Nonsignificant None -- -- olfactory receptor -- ko04740 Olfactory transduction -- -- -- -- -- -- Q9CS74 Protein ecdysoneless homolog Ecd 260.6 263.8 256.6 215.5 219.3 214.3 1.20320443691265 0.0000685613976993743 0.266881792191413 Nonsignificant None -- -- -- -- -- MADS box transcription factor K Transcription ; IPR010770 [Ecd family] -- -- B9EKH3 Uncharacterized protein 354.5 363.3 338.2 387.3 366.5 374.8 0.935672514619883 0.0638214491635704 -0.0959244199985354 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- E0CYA6 Mediator of RNA polymerase II transcription subunit 6 Med6 83.9 79.3 68.7 61.9 73.8 77.2 1.08924377642085 0.382587801138453 0.123326870193709 Nonsignificant None 3 Molecular Function:RNA polymerase II transcription cofactor activity (GO:0001104),Biological Process:regulation of transcription from RNA polymerase II promoter (GO:0006357),Cellular Component:mediator complex (GO:0016592) mediator of RNA polymerase II transcription subunit 6 -- -- RNA polymerase II transcriptional regulation mediator K Transcription ; IPR007018 [Mediator complex, subunit Med6] -- -- A0A2R8VHR3 Mannan-binding lectin serine protease 1 Masp1 127 127.5 131.3 162.8 133.4 149.4 0.865798922800718 0.140364924130863 -0.207896089290928 Nonsignificant None -- -- mannan-binding lectin serine protease 1 3.4.21.- ko04610 Complement and coagulation cascades ko05150 Staphylococcus aureus infection Trypsin E Amino acid transport and metabolism ; IPR000436 [Sushi/SCR/CCP domain] ; IPR000859[CUB domain] -- -- Q5FW98 Cytochrome c oxidase subunit VIIb Cox7b 358.5 192.1 339.9 400.5 421.7 390.5 0.734311866083945 0.114828183406607 -0.445535181551997 Nonsignificant None 2 Molecular Function:cytochrome-c oxidase activity (GO:0004129),Cellular Component:mitochondrial respiratory chain (GO:0005746) cytochrome c oxidase subunit 7b -- ko00190 Oxidative phosphorylation ko01100 Metabolic pathways ko04260 Cardiac muscle contraction ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05010 Alzheimer's disease ko05012 Parkinson's disease ko05016 Huntington's disease -- -- -- IPR008433 [Cytochrome C oxidase, subunit VIIB] -- -- A0A1D5RLV3 Protein unc-80 homolog Unc80 71 239 300.6 314.4 565.8 239.7 0.545227252433253 0.230549248116179 -0.875070419817446 Nonsignificant None -- -- -- -- -- -- -- -- IPR031542 [Cation channel complex component UNC80, N-terminal] -- -- Q8VC90 Palmitoyltransferase ZDHHC12 Zdhhc12 109.9 109 117.9 110.9 101.4 112.8 1.03598892648416 0.43694514895145 0.0510085823760401 Nonsignificant None -- -- palmitoyltransferase 2.3.1.225 -- DHHC-type Zn-finger proteins R General function prediction only ; IPR001594 [Palmitoyltransferase, DHHC domain] -- -- Q3UN31 Phospholipase A(2) Pla2g6 5.1 3.7 0 4.9 5.5 3.1 0.977777777777778 0.931251565684245 -0.0324214776923773 Nonsignificant None 1 Biological Process:lipid metabolic process (GO:0006629) calcium-independent phospholipase A2 3.1.1.4 ko00564 Glycerophospholipid metabolism ko00565 Ether lipid metabolism ko00590 Arachidonic acid metabolism ko00591 Linoleic acid metabolism ko00592 alpha-Linolenic acid metabolism ko01100 Metabolic pathways ko04014 Ras signaling pathway ko04270 Vascular smooth muscle contraction ko04750 Inflammatory mediator regulation of TRP channels Ca2+-independent phospholipase A2 I Lipid transport and metabolism ; IPR002641 [Patatin/Phospholipase A2-related] ; IPR020683[Ankyrin repeat-containing domain] -- -- P14231 Sodium/potassium-transporting ATPase subunit beta-2 Atp1b2 258.5 263.5 282.7 306.5 329.7 322.5 0.839365807864817 0.0069945359827194 -0.252628399627054 Nonsignificant None 3 Cellular Component:sodium:potassium-exchanging ATPase complex (GO:0005890),Biological Process:potassium ion transport (GO:0006813),Biological Process:sodium ion transport (GO:0006814) sodium/potassium-transporting ATPase subunit beta -- ko04022 cGMP-PKG signaling pathway ko04024 cAMP signaling pathway ko04260 Cardiac muscle contraction ko04261 Adrenergic signaling in cardiomyocytes ko04911 Insulin secretion ko04918 Thyroid hormone synthesis ko04919 Thyroid hormone signaling pathway ko04925 Aldosterone synthesis and secretion ko04960 Aldosterone-regulated sodium reabsorption ko04961 Endocrine and other factor-regulated calcium reabsorption ko04964 Proximal tubule bicarbonate reclamation ko04970 Salivary secretion ko04971 Gastric acid secretion ko04972 Pancreatic secretion ko04973 Carbohydrate digestion and absorption ko04974 Protein digestion and absorption ko04976 Bile secretion ko04978 Mineral absorption Na+/K+ ATPase, beta subunit P Inorganic ion transport and metabolism ; IPR000402 [Sodium/potassium-transporting ATPase subunit beta] -- -- Q91WD1 DNA-directed RNA polymerase III subunit RPC4 Polr3d 75.6 69.5 90.4 93.2 94.8 94.5 0.833628318584071 0.126663355188711 -0.262523807689767 Nonsignificant None 4 Molecular Function:DNA binding (GO:0003677),Molecular Function:DNA-directed 5'-3' RNA polymerase activity (GO:0003899),Cellular Component:DNA-directed RNA polymerase III complex (GO:0005666),Biological Process:transcription from RNA polymerase III promoter (GO:0006383) DNA-directed RNA polymerase III subunit RPC4 -- ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways ko03020 RNA polymerase ko04623 Cytosolic DNA-sensing pathway ko05169 Epstein-Barr virus infection DNA-directed RNA polymerase III subunit K Transcription ; IPR007811 [DNA-directed RNA polymerase III subunit RPC4] -- -- Q91XX7 Protocadherin gamma B2 Pcdhgb2 28.2 83.1 23.6 64.3 112.8 52.5 0.587543554006969 0.300459643274801 -0.76723229372742 Nonsignificant None 3 Molecular Function:calcium ion binding (GO:0005509),Biological Process:homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156),Cellular Component:membrane (GO:0016020) protocadherin gamma subfamily B -- -- FOG: Cadherin repeats S Function unknown ; IPR002126 [Cadherin] ; IPR013164[Cadherin, N-terminal] ; IPR031904[Cadherin, C-terminal catenin-binding domain] ; IPR032455[Cadherin, cytoplasmic C-terminal domain] -- -- E9PYQ0 Radial spoke head 10 homolog B Rsph10b 148.6 154.9 26.1 170.6 170 170.1 0.645388682200901 0.286545388394084 -0.631759816529197 Nonsignificant None -- -- amyotrophic lateral sclerosis 2 protein -- ko05014 Amyotrophic lateral sclerosis (ALS) Junctional membrane complex protein Junctophilin and related MORN repeat proteins R General function prediction only ; IPR003409 [MORN motif] -- -- D3YUY3 Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha Pip5k1a 92.1 90 78.6 94.8 84.8 87.3 0.976770325964781 0.709205907057022 -0.0339087226064102 Nonsignificant None 2 Molecular Function:phosphatidylinositol phosphate kinase activity (GO:0016307),Biological Process:phosphatidylinositol metabolic process (GO:0046488) 1-phosphatidylinositol-4-phosphate 5-kinase 2.7.1.68 ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system ko04072 Phospholipase D signaling pathway ko04144 Endocytosis ko04666 Fc gamma R-mediated phagocytosis ko04810 Regulation of actin cytoskeleton ko05231 Choline metabolism in cancer Phosphatidylinositol-4-phosphate 5-kinase T Signal transduction mechanisms ; IPR002498 [Phosphatidylinositol-4-phosphate 5-kinase, core] -- -- Q8BMD7 MORC family CW-type zinc finger protein 4 Morc4 61.2 52.9 35.2 83.7 114.1 64.9 0.568328892272554 0.0806622464092928 -0.815202034999091 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) -- -- -- -- -- -- IPR011124 [Zinc finger, CW-type] -- -- A0A1D5RLL6 Dynamin-binding protein Dnmbp 115.7 122.3 122.3 118.3 136.2 140.8 0.911459650898052 0.180803721710177 -0.133749303392823 Nonsignificant None 4 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Molecular Function:protein binding (GO:0005515),Cellular Component:cytoplasm (GO:0005737),Biological Process:regulation of Rho protein signal transduction (GO:0035023) dynamin-binding protein -- -- Invasion-inducing protein TIAM1/CDC24 and related RhoGEF GTPases T Signal transduction mechanisms ; IPR000219 [Dbl homology (DH) domain] ; IPR001452[SH3 domain] ; IPR004148[BAR domain] -- -- P59997 Lysine-specific demethylase 2A Kdm2a 81.8 87.1 73.1 55.6 55.6 63.8 1.38285714285714 0.0104422188240449 0.467652125442265 Nonsignificant None 3 Molecular Function:DNA binding (GO:0003677),Molecular Function:protein binding (GO:0005515),Molecular Function:zinc ion binding (GO:0008270) F-box and leucine-rich repeat protein 10/11 1.14.11.27 -- F-box protein JEMMA and related proteins with JmjC, PHD, F-box and LRR domains B Chromatin structure and dynamics ; IPR001810 [F-box domain] ; IPR002857[Zinc finger, CXXC-type] ; IPR003347[JmjC domain] ; IPR019787[Zinc finger, PHD-finger] -- -- Q4VA02 Rp1 protein (Fragment) Rp1 109.8 126.4 146.4 137 151.1 142.1 0.889353788935379 0.234848752755154 -0.169170651076949 Nonsignificant None 1 Biological Process:intracellular signal transduction (GO:0035556) retinitis pigmentosa 1 -- -- FOG: Low-complexity S Function unknown ; IPR003533 [Doublecortin domain] -- -- Q80XQ1 Ccdc88c protein Ccdc88c 14.3 11.2 14.3 7.5 5.5 14.3 1.45787545787546 0.218449904505785 0.543867479623797 Nonsignificant None -- -- -- -- -- Uncharacterized coiled-coil protein S Function unknown ; IPR008636 [Hook-related protein family] -- -- P23589 Carbonic anhydrase 5A, mitochondrial Ca5a 435.8 392.1 143.4 159.2 181.6 153.6 1.96460355987055 0.222158203018672 0.974238218381389 Nonsignificant None -- -- carbonic anhydrase 4.2.1.1 ko00910 Nitrogen metabolism Carbonic anhydrase R General function prediction only ; IPR001148 [Alpha carbonic anhydrase] -- -- A0A494BAL8 Farnesylated proteins-converting enzyme 2 Rce1 157.3 148.6 147.5 164.7 176.1 167.9 0.891291527422843 0.0159981984379581 -0.166030703121843 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) prenyl protein peptidase 3.4.22.- ko00900 Terpenoid backbone biosynthesis Prenyl protein protease O Posttranslational modification, protein turnover, chaperones ; IPR003675 [CAAX amino terminal protease] -- -- Q3URU2 Paternally-expressed gene 3 protein Peg3 125.3 137.8 20.9 198.6 265.5 119.7 0.486467968482357 0.149532085946301 -1.03958328111022 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) SCAN domain-containing zinc finger protein -- -- FOG: Zn-finger R General function prediction only ; IPR007087 [Zinc finger, C2H2] -- zf-C2H2 Q3TCV3 Gamma-secretase-activating protein Gsap 86.5 78.3 83 73.5 72.3 82.6 1.08493870402802 0.183595988459437 0.117613536777759 Nonsignificant None -- -- -- -- -- -- -- -- IPR028010 [Gamma-secretase-activating protein, C-terminal domain] -- -- Q8CJH3 Plexin-B1 Plxnb1 150.5 140.8 131.1 136 129.5 151.3 1.01343570057582 0.83787983566644 0.0192545570799454 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:membrane (GO:0016020) plexin B -- ko04360 Axon guidance Plexins (functional semaphorin receptors) T Signal transduction mechanisms ; IPR001627 [Sema domain] ; IPR002165[Plexin repeat] ; IPR002909[IPT domain] ; IPR013548[Plexin, cytoplasmic RasGAP domain] -- -- F7B2J7 Mucolipin-2 (Fragment) Mcoln2 72 83.5 17 37.7 63.7 57.1 1.08832807570978 0.842057218916856 0.122113521526124 Nonsignificant None -- -- mucolipin 2 -- -- Mucolipidin and related proteins (TRML subfamily of transient receptor potential proteins) P Inorganic ion transport and metabolism ; -- -- -- Q9D4J7 PHD finger protein 6 Phf6 63.5 115.3 77.2 153.9 88.5 77.6 0.8 0.494634515637027 -0.321928094887363 Nonsignificant None -- -- -- -- -- Transcription factor TCF20 K Transcription ; -- -- -- D3YZ08 Telomeric repeat-binding factor Terf2 82.5 63.3 65.4 65.7 66.2 88.2 0.959563834620627 0.772535096302151 -0.0595493105331038 Nonsignificant None 2 Molecular Function:telomeric DNA binding (GO:0042162),Molecular Function:protein homodimerization activity (GO:0042803) telomeric repeat-binding factor 2 -- -- -- -- -- IPR001005 [SANT/Myb domain] ; IPR013867[Telomere repeat-binding factor, dimerisation domain] ; IPR031902[Telomeric repeat-binding factor 2, Rap1-binding domain] -- MYB Q9QZ25 Vascular non-inflammatory molecule 3 Vnn3 143 151.2 146.7 184.6 189.3 184.6 0.789435989256938 0.000160061632087214 -0.34110580375493 Nonsignificant None 1 Biological Process:nitrogen compound metabolic process (GO:0006807) pantetheine hydrolase 3.5.1.92 ko00770 Pantothenate and CoA biosynthesis Carbon-nitrogen hydrolase E Amino acid transport and metabolism ; IPR003010 [Carbon-nitrogen hydrolase] -- -- Q3V4D3 CIDE-N domain-containing protein Cideb 76.2 70.6 72.8 75.7 81.5 71.3 0.961050328227571 0.428790752928807 -0.0573161109402335 Nonsignificant None 2 Cellular Component:intracellular (GO:0005622),Biological Process:apoptotic process (GO:0006915) -- -- -- -- -- -- IPR003508 [CIDE-N domain] -- -- Q9JJM6 Sialyltransferase (Fragment) St6gal1 170.6 176.1 182.4 242.4 250.6 248.8 0.713265031005662 0.0000735888869833046 -0.487489850095671 Nonsignificant None 2 Biological Process:protein glycosylation (GO:0006486),Molecular Function:sialyltransferase activity (GO:0008373) beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 1) 2.4.99.1 ko00510 N-Glycan biosynthesis ko00514 Other types of O-glycan biosynthesis ko01100 Metabolic pathways Sialyltransferase G Carbohydrate transport and metabolism ; IPR001675 [Glycosyl transferase family 29] -- -- F6UTM6 Group XIIB secretory phospholipase A2-like protein (Fragment) Pla2g12b 177.7 186.7 227.8 187.2 194.5 155.7 1.10197245999256 0.401504147845496 0.140088169164388 Nonsignificant None 4 Molecular Function:phospholipase A2 activity (GO:0004623),Molecular Function:calcium ion binding (GO:0005509),Cellular Component:extracellular region (GO:0005576),Biological Process:lipid catabolic process (GO:0016042) secretory phospholipase A2 3.1.1.4 ko00564 Glycerophospholipid metabolism ko00565 Ether lipid metabolism ko00590 Arachidonic acid metabolism ko00591 Linoleic acid metabolism ko00592 alpha-Linolenic acid metabolism ko01100 Metabolic pathways ko04014 Ras signaling pathway ko04270 Vascular smooth muscle contraction ko04972 Pancreatic secretion ko04975 Fat digestion and absorption -- -- -- IPR010711 [Group XII secretory phospholipase A2 precursor] -- -- B7ZC91 F-box/WD repeat-containing protein 10 Fbxw10 90.9 88.8 88.5 98.5 91.8 103.6 0.912555290915277 0.0705839161044531 -0.132016121746859 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) F-box and WD-40 domain protein 10 -- -- Cdc4 and related F-box and WD-40 proteins R General function prediction only ; IPR001680 [WD40 repeat] -- -- Q8CBZ9 Protein FAM149A (Fragment) Fam149a 107.1 103.3 123.1 143.1 141.7 139.6 0.785815268614515 0.00789674931916538 -0.347737894842818 Nonsignificant None -- -- -- -- -- -- -- -- IPR022194 [Protein of unknown function DUF3719] -- -- Q1MXF8 Sodium channel beta2 subunit Scn2b 43.6 45 24.7 59.4 68.8 42 0.665687426556992 0.13710235840576 -0.587083175865447 Nonsignificant None -- -- voltage-gated sodium channel type II beta -- -- -- -- -- IPR013106 [Immunoglobulin V-set domain] -- -- Q91XL2 Ligand of Numb protein X 2 Lnx2 150.5 147.7 141.8 127.2 127.5 133.9 1.1322696860525 0.00705175787085776 0.179217622826677 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) ligand of Numb protein X 1/2 2.3.2.27 -- FOG: PDZ domain S Function unknown ; IPR001478 [PDZ domain] -- -- Q3TL84 Uncharacterized protein (Fragment) Irag2 25.7 29.6 29.4 41.7 37.2 31.8 0.76513098464318 0.0503939961089883 -0.386221347449354 Nonsignificant None -- -- -- -- -- -- -- -- IPR008677 [MRVI1] -- -- Q5DU39 MKIAA0279 protein (Fragment) Celsr2 83.7 82.8 64 145.7 143.7 105.8 0.583248987854251 0.0192508106675539 -0.777816196267977 Significant down 5 Molecular Function:G-protein coupled receptor activity (GO:0004930),Molecular Function:protein binding (GO:0005515),Biological Process:G-protein coupled receptor signaling pathway (GO:0007186),Cellular Component:membrane (GO:0016020),Cellular Component:integral component of membrane (GO:0016021) cadherin EGF LAG seven-pass G-type receptor 2 -- -- Cadherin EGF LAG seven-pass G-type receptor T Signal transduction mechanisms ; IPR000203 [GPS motif] ; IPR000742[EGF-like domain] ; IPR000832[GPCR, family 2, secretin-like] ; IPR001791[Laminin G domain] ; IPR002049[Laminin EGF domain] ; IPR032471[GAIN domain, N-terminal] -- -- Q4G0C1 Signal transducer and activator of transcription Stat4 278 289.3 246.2 269.7 253.9 284.8 1.00630875804057 0.918916427312986 0.00907302418015467 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Biological Process:signal transduction (GO:0007165) signal transducer and activator of transcription 4 -- ko04217 Necroptosis ko04630 Jak-STAT signaling pathway ko04658 Th1 and Th2 cell differentiation ko05161 Hepatitis B ko05200 Pathways in cancer ko05321 Inflammatory bowel disease (IBD) STAT protein KT Transcription ; Signal transduction mechanisms ; IPR000980 [SH2 domain] ; IPR013799[STAT transcription factor, protein interaction] ; IPR013800[STAT transcription factor, all-alpha domain] ; IPR013801[STAT transcription factor, DNA-binding] -- STAT Q6RUT8 Coiled-coil domain-containing protein 154 Ccdc154 546.1 622.4 558.8 573.9 556.2 576.6 1.01207007675631 0.792796495427048 0.0173091871553674 Nonsignificant None -- -- -- -- -- -- -- -- IPR029512 [Coiled-coil domain-containing protein 154] -- -- A2AIW0 Endosome-associated-trafficking regulator 1 Entr1 294.8 302.5 493.2 451.2 551.3 395.8 0.779875563183866 0.265136935016626 -0.358684148731987 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- A0A0R4J057 E3 ubiquitin-protein ligase pellino homolog Peli3 42.9 33 27.2 35.4 39 29.6 0.991346153846154 0.957885442520367 -0.0125391956603461 Nonsignificant None 1 Biological Process:Toll signaling pathway (GO:0008063) pellino 2.3.2.27 -- Adaptor protein Pellino T Signal transduction mechanisms ; IPR006800 [Pellino family] -- -- Q8VHX1 Zinc finger protein 352 Zfp352 22.2 17.9 15.7 20.8 13.8 18.4 1.05283018867925 0.755936831222338 0.0742727623786257 Nonsignificant None -- -- -- -- -- FOG: Zn-finger R General function prediction only ; -- -- zf-C2H2 E9QQ35 Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma (Fragment) Pik3c2g 212.3 260.9 120.6 360.7 414.6 230.9 0.590141125024846 0.114425325282278 -0.760868096298847 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Molecular Function:kinase activity (GO:0016301),Molecular Function:phosphatidylinositol binding (GO:0035091) phosphatidylinositol-4-phosphate 3-kinase 2.7.1.154 ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system Phosphoinositide 3-kinase T Signal transduction mechanisms ; IPR000008 [C2 domain] ; IPR000403[Phosphatidylinositol 3-/4-kinase, catalytic domain] ; IPR001263[Phosphoinositide 3-kinase, accessory (PIK) domain] ; IPR001683[Phox homologous domain] ; IPR002420[Phosphatidylinositol 3-kinase, C2 domain] -- -- Q80U19 Disheveled-associated activator of morphogenesis 2 Daam2 44.5 45.2 44.5 39.7 35.5 35.2 1.21557971014493 0.00572108434767915 0.281644499422014 Nonsignificant None 4 Molecular Function:actin binding (GO:0003779),Biological Process:cellular component organization (GO:0016043),Molecular Function:Rho GTPase binding (GO:0017048),Biological Process:actin cytoskeleton organization (GO:0030036) dishevelled associated activator of morphogenesis -- ko04310 Wnt signaling pathway Rho GTPase effector BNI1 and related formins TZ Signal transduction mechanisms ; Cytoskeleton ; IPR010472 [Formin, FH3 domain] ; IPR010473[Formin, GTPase-binding domain] ; IPR015425[Formin, FH2 domain] -- -- P43081 Guanylyl cyclase-activating protein 1 Guca1a 24.4 20.7 21.2 21 19.1 29.8 0.948497854077253 0.748542018479936 -0.0762835852628489 Nonsignificant None 1 Molecular Function:calcium ion binding (GO:0005509) guanylate cyclase activator 1 -- ko04744 Phototransduction Ca2+ sensor (EF-Hand superfamily) T Signal transduction mechanisms ; IPR002048 [EF-hand domain] -- -- A2ACJ2 Fanconi anemia core complex-associated protein 100 Faap100 75.7 74.2 80 87.7 101.9 87.9 0.828468468468469 0.0339847738055371 -0.27148130540665 Nonsignificant None 2 Biological Process:DNA repair (GO:0006281),Cellular Component:Fanconi anaemia nuclear complex (GO:0043240) fanconi anemia core complex 100 kDa subunit -- ko03460 Fanconi anemia pathway -- -- -- IPR029251 [Fanconi anemia-associated protein of 100kDa] -- -- Q8VBX6 Multiple PDZ domain protein Mpdz 163.7 173.2 165.1 159 184.9 171.9 0.973245443970531 0.597921536244411 -0.03912440895108 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) multiple PDZ domain protein -- ko04530 Tight junction FOG: PDZ domain S Function unknown ; IPR001478 [PDZ domain] ; IPR015132[L27-2] ; IPR032078[Multiple PDZ domain protein] -- -- O35625 Axin-1 Axin1 651.8 592.8 524 292.9 295.9 368.9 1.84671609063381 0.00371465267492236 0.884962087155185 Significant up -- -- axin 1 -- ko04310 Wnt signaling pathway ko04390 Hippo signaling pathway ko04550 Signaling pathways regulating pluripotency of stem cells ko05165 Human papillomavirus infection ko05200 Pathways in cancer ko05210 Colorectal cancer ko05213 Endometrial cancer ko05217 Basal cell carcinoma ko05224 Breast cancer ko05225 Hepatocellular carcinoma ko05226 Gastric cancer G protein signaling regulators T Signal transduction mechanisms ; IPR001158 [DIX domain] ; IPR014936[Axin beta-catenin binding] ; IPR016137[RGS domain] ; IPR032101[Axin-1/2, tankyrase-binding domain] -- -- Q3TWF6 WD repeat-containing protein 70 Wdr70 236.4 205.7 198.9 183.2 193.9 195 1.12043349064849 0.131316704983623 0.164057012472191 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Uncharacterized conserved protein, contains WD40 repeat S Function unknown ; IPR001680 [WD40 repeat] -- -- P28651 Carbonic anhydrase-related protein Ca8 169.1 166.2 284.9 198.6 182 168.4 1.12969034608379 0.585382820597792 0.175927376720061 Nonsignificant None -- -- carbonic anhydrase 4.2.1.1 ko00910 Nitrogen metabolism Carbonic anhydrase R General function prediction only ; IPR001148 [Alpha carbonic anhydrase] -- -- Q9QXX5 Sodium-glucose cotransporter 1 Slc5a1 174.7 205.8 253.9 252.6 243.1 218.4 0.88839098165523 0.351107568457946 -0.170733347193052 Nonsignificant None 4 Molecular Function:transporter activity (GO:0005215),Biological Process:transport (GO:0006810),Cellular Component:membrane (GO:0016020),Biological Process:transmembrane transport (GO:0055085) solute carrier family 5 (sodium/glucose cotransporter), member 1 -- ko04973 Carbohydrate digestion and absorption ko04976 Bile secretion ko04978 Mineral absorption Na+:iodide/myo-inositol/multivitamin symporters P Inorganic ion transport and metabolism ; IPR001734 [Sodium/solute symporter] -- -- O09053 Bifunctional 3-5 exonuclease/ATP-dependent helicase WRN Wrn 85.7 86.1 86 64.1 72.9 79.2 1.19241443108233 0.0868045426127141 0.253885740627001 Nonsignificant None 8 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524),Cellular Component:intracellular (GO:0005622),Biological Process:nucleobase-containing compound metabolic process (GO:0006139),Biological Process:DNA replication (GO:0006260),Biological Process:DNA repair (GO:0006281),Molecular Function:3'-5' exonuclease activity (GO:0008408),Molecular Function:ATP-dependent 3'-5' DNA helicase activity (GO:0043140) werner syndrome ATP-dependent helicase 3.6.4.12 -- ATP-dependent DNA helicase L Replication, recombination and repair ; IPR001650 [Helicase, C-terminal] ; IPR002121[HRDC domain] ; IPR002562[3'-5' exonuclease domain] ; IPR011545[DEAD/DEAH box helicase domain] ; IPR018982[RQC domain] ; IPR029491[Helicase Helix-turn-helix domain] ; IPR032284[ATP-dependent DNA helicase RecQ, zinc-binding domain] -- -- P27664 Rod cGMP-specific 3,5-cyclic phosphodiesterase subunit alpha Pde6a 214.2 240.4 300 285.3 332.7 294.8 0.826687116564417 0.145491692723573 -0.274586691478572 Nonsignificant None 3 Molecular Function:3',5'-cyclic-nucleotide phosphodiesterase activity (GO:0004114),Molecular Function:protein binding (GO:0005515),Biological Process:signal transduction (GO:0007165) rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha 3.1.4.35 ko00230 Purine metabolism ko04744 Phototransduction Cyclic nucleotide phosphodiesterase T Signal transduction mechanisms ; IPR002073 [3'5'-cyclic nucleotide phosphodiesterase, catalytic domain] ; IPR003018[GAF domain] -- -- Q8BGB5 LIM domain-containing protein 2 Limd2 291.6 308.5 228.3 212.3 251.5 227.2 1.19884225759768 0.164465122141696 0.261641842944891 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) -- -- -- Regulatory protein MLP and related LIM proteins TZ Signal transduction mechanisms ; Cytoskeleton ; IPR001781 [Zinc finger, LIM-type] -- -- Q3V036 Coiled-coil domain-containing protein 27 Ccdc27 179.3 182.2 83 257.7 310.8 182.6 0.591798695246971 0.10763387046146 -0.756821579096994 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q9DAA6 Exosome complex component CSL4 Exosc1 60.1 65.2 64.3 57 51 52.8 1.17910447761194 0.0155279388131449 0.237691557719331 Nonsignificant None 2 Cellular Component:exosome (RNase complex) (GO:0000178),Molecular Function:RNA binding (GO:0003723) exosome complex component CSL4 -- ko03018 RNA degradation Exosomal 3'-5' exoribonuclease complex, subunit ski4 (Csl4) J Translation, ribosomal structure and biogenesis ; IPR019495 [Exosome complex component CSL4] ; IPR025721[Exosome complex component, N-terminal domain] -- -- A0EQY3 Condensin-2 complex subunit D3 Ncapd3 193.3 178.8 149.5 117.6 142.2 132 1.33129147524247 0.0424744021281865 0.412826471963491 Nonsignificant None -- -- condensin-2 complex subunit D3 -- -- Uncharacterized conserved protein related to condensin complex subunit 1 S Function unknown ; IPR032682 [Condensin complex subunit 1, C-terminal] -- -- A0A0D2X7Z2 EEF1A lysine methyltransferase 1 Eef1akmt1 46.3 54.1 57.4 56.4 59.1 54.1 0.930424528301887 0.335268364377116 -0.104038964549741 Nonsignificant None 1 Molecular Function:methyltransferase activity (GO:0008168) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019369 [Protein-lysine N-methyltransferase Efm5] -- -- Q9JJ89 Coiled-coil domain-containing protein 86 Ccdc86 333.3 354.8 333.3 301 319.4 295.2 1.11555264307558 0.0260861410796237 0.157758596156729 Nonsignificant None -- -- rRNA-processing protein CGR1 -- -- Predicted coiled-coil protein R General function prediction only ; IPR005579 [Cgr1-like] -- -- Q3URS8 Uncharacterized protein Mlf2 21.7 19.8 17.3 26.1 20.6 23.7 0.835227272727273 0.130796604870779 -0.259759273800933 Nonsignificant None -- -- -- -- -- Proliferation-related protein MLF S Function unknown ; IPR019376 [Myeloid leukemia factor] -- -- F6M2J9 Nuclear receptor coactivator-6 beta Ncoa6 458.1 479.4 544.6 421.9 500.7 477.2 1.05879411344478 0.476560549121479 0.0824220790471633 Nonsignificant None -- -- nuclear receptor coactivator 6 -- -- -- -- -- IPR032715 [Nuclear receptor coactivator 6, putative nucleic acid-binding region] -- -- Q3TFQ1 SPRY domain-containing protein 7 Spryd7 173.5 161.8 195.3 202.7 189 189.4 0.913095852693168 0.194051231694331 -0.131161779095714 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- Uncharacterized conserved protein, contains SPRY domain S Function unknown ; IPR003877 [SPRY domain] -- -- O70557 Small proline-rich protein 2F Sprr2f 53.4 42.8 16.2 21.2 34.4 29.5 1.32079905992949 0.480709157626283 0.401410998534964 Nonsignificant None 1 Cellular Component:cornified envelope (GO:0001533) -- -- -- -- -- -- IPR029142 [Small proline-rich protein 2] -- -- Q8BLS7 Ankyrin repeat domain-containing protein SOWAHA Sowaha 124.8 135.4 228.9 231.6 244.9 155.4 0.774014875771483 0.332953904288701 -0.36956680113329 Nonsignificant None -- -- -- -- -- -- -- -- IPR020683 [Ankyrin repeat-containing domain] -- -- Q61152 Tyrosine-protein phosphatase non-receptor type 18 Ptpn18 18.7 16.1 16.2 15.1 15.1 17.8 1.0625 0.464620924015451 0.0874628412503394 Nonsignificant None 2 Molecular Function:protein tyrosine phosphatase activity (GO:0004725),Biological Process:protein dephosphorylation (GO:0006470) tyrosine-protein phosphatase non-receptor type 12/18/22 3.1.3.48 -- Protein tyrosine phosphatase T Signal transduction mechanisms ; IPR000242 [PTP type protein phosphatase] -- -- Q9D3F7 DNA damage-inducible transcript 4 protein Ddit4 190.1 195.2 275 229.8 201.1 240.9 0.982881810062519 0.904294479552849 -0.0249101496217852 Nonsignificant None 2 Cellular Component:cytoplasm (GO:0005737),Biological Process:negative regulation of signal transduction (GO:0009968) DNA-damage-inducible transcript 4 -- ko04140 Autophagy - animal ko04150 mTOR signaling pathway ko04151 PI3K-Akt signaling pathway ko05206 MicroRNAs in cancer -- -- -- IPR012918 [RTP801-like] -- -- A0A1W2P872 RNA-binding protein Nova-2 Nova2 120.9 100.1 161 183.8 190.8 189.4 0.677304964539007 0.0748998087669667 -0.562122524363045 Nonsignificant None 1 Molecular Function:RNA binding (GO:0003723) RNA-binding protein Nova -- -- RNA-binding protein NOVA1/PASILLA and related KH domain proteins AR RNA processing and modification ; General function prediction only ; IPR004088 [K Homology domain, type 1] -- -- Q91X58 AN1-type zinc finger protein 2B Zfand2b 124 120.1 125.8 105.2 99.4 100.2 1.21358267716535 0.000932279324980005 0.279272397630673 Nonsignificant None 1 Molecular Function:zinc ion binding (GO:0008270) -- -- -- Predicted Zn-finger protein R General function prediction only ; IPR000058 [Zinc finger, AN1-type] -- -- Q6PHZ5 Putative RNA-binding protein 15B Rbm15b 56.4 93.2 87.1 89.4 91.1 84.4 0.893544733861835 0.461874818706521 -0.162388137635007 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) RNA-binding protein 15 -- -- Large RNA-binding protein (RRM superfamily) R General function prediction only ; IPR000504 [RNA recognition motif domain] ; IPR012921[Spen paralogue and orthologue SPOC, C-terminal] -- -- Q99PG4 Regulator of G-protein signaling 18 Rgs18 202.6 196.8 258 245.3 219.3 298.4 0.861598951507208 0.310900990352331 -0.214911600641583 Nonsignificant None -- -- regulator of G-protein signaling -- -- G protein signaling regulators T Signal transduction mechanisms ; IPR016137 [RGS domain] -- -- Q3U8D5 Uncharacterized protein (Fragment) Ext2 96.1 110.7 124.5 123.9 113.5 120.3 0.926195135588482 0.371360428829457 -0.110611914914211 Nonsignificant None 3 Biological Process:glycosaminoglycan biosynthetic process (GO:0006024),Biological Process:heparan sulfate proteoglycan biosynthetic process (GO:0015012),Cellular Component:integral component of membrane (GO:0016021) -- -- ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin ko01100 Metabolic pathways Acetylglucosaminyltransferase EXT2/exostosin 2 GMW Carbohydrate transport and metabolism ; Cell wall/membrane/envelope biogenesis ; Extracellular structures ; IPR004263 [Exostosin-like] ; IPR015338[Exostosin , C-terminal] -- -- Q3UXZ6 Protein FAM81A Fam81a 823.7 704.3 127.5 138.2 128.8 148.1 3.98819561551433 0.194238923926689 1.99573617368075 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q91WT4 DnaJ homolog subfamily C member 17 Dnajc17 161.8 163.5 146.4 163.8 220.1 201.2 0.806186976585199 0.0957315043789292 -0.310813617289672 Nonsignificant None 1 Molecular Function:nucleic acid binding (GO:0003676) DnaJ homolog subfamily C member 17 -- -- Molecular chaperone (DnaJ superfamily) O Posttranslational modification, protein turnover, chaperones ; IPR000504 [RNA recognition motif domain] ; IPR001623[DnaJ domain] -- -- Q8BU25 Inactive serine protease PAMR1 Pamr1 90.5 154.3 89 75.3 78.6 56.9 1.58349146110057 0.143246549141197 0.663109087725384 Nonsignificant None 3 Molecular Function:serine-type endopeptidase activity (GO:0004252),Molecular Function:protein binding (GO:0005515),Biological Process:proteolysis (GO:0006508) -- -- -- Trypsin E Amino acid transport and metabolism ; IPR000436 [Sushi/SCR/CCP domain] ; IPR000742[EGF-like domain] ; IPR000859[CUB domain] ; IPR001254[Serine proteases, trypsin domain] -- -- Q3U6G8 Mortality factor 4-like protein 2 Morf4l2 371 370.3 318.4 296.7 300.7 283.4 1.20311080835604 0.0305262932736937 0.266769523065713 Nonsignificant None -- -- mortality factor 4-like protein 2 -- -- Dosage compensation regulatory complex/histone acetyltransferase complex, subunit MSL-3/MRG15/EAF3, and related CHROMO domain-containing proteins BK Chromatin structure and dynamics ; Transcription ; IPR026541 [MRG domain] -- -- Q8K214 Polycomb protein SCMH1 Scmh1 135.9 108.4 145.9 145.5 149.8 134.6 0.907652942544778 0.335178581037774 -0.139787332374276 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:nucleus (GO:0005634) polycomb protein SCMH1 -- -- Polycomb group protein SCM/L(3)MBT (tumor-supressor in Drosophila and humans) K Transcription ; IPR001660 [Sterile alpha motif domain] ; IPR004092[Mbt repeat] ; IPR021987[SLED domain] ; IPR033763[Polycomb group protein, RNA binding region] -- -- Q8R0R3 Sclt1 protein (Fragment) Sclt1 232.7 198.1 201.7 181.1 202.8 210.4 1.06427730102642 0.416341060461326 0.089874098858392 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q3TSB2 Uncharacterized protein Zbed3 41.4 35 39.6 40.7 42.3 46.9 0.892994611239415 0.156697504497072 -0.163276625432947 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q60841 Reelin Reln 24 24 23.4 21.6 30.4 18.9 1.00705218617772 0.966106389201413 0.0101384467895836 Nonsignificant None -- -- reelin 3.4.21.- ko04151 PI3K-Akt signaling pathway ko04510 Focal adhesion ko04512 ECM-receptor interaction ko05165 Human papillomavirus infection -- -- -- IPR002861 [Reeler domain] -- -- A4FUR8 Synaptophysin (Fragment) Syp 254.9 275.5 338.8 311.4 320.9 327.3 0.905794080867028 0.305450561724407 -0.142744983112152 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) -- -- -- -- -- -- IPR008253 [Marvel domain] -- -- O89029 Matrilin-4 Matn4 60.1 61.8 44.8 60.2 84.1 59.1 0.819567354965585 0.279365807517939 -0.287065574871083 Nonsignificant None -- -- -- -- -- Fibrillins and related proteins containing Ca2+-binding EGF-like domains T Signal transduction mechanisms ; IPR002035 [von Willebrand factor, type A] ; IPR019466[Matrilin, coiled-coil trimerisation domain] -- -- Q52KI9 Zfp592 protein Zfp592 24.8 21.9 26.1 27.5 27.6 23.5 0.926208651399491 0.351329297705358 -0.11059086205991 Nonsignificant None 1 Molecular Function:metal ion binding (GO:0046872) zinc finger protein 592 -- -- FOG: Zn-finger R General function prediction only ; IPR007087 [Zinc finger, C2H2] -- zf-C2H2 A0A217FL49 Uridine diphosphate glucose pyrophosphatase NUDT14 Nudt14 63.1 88.8 109.6 144.5 116.8 103 0.717814987647543 0.1321993306288 -0.478316048608479 Nonsignificant None 1 Molecular Function:hydrolase activity (GO:0016787) UDP-sugar diphosphatase 3.6.1.45 -- Uncharacterized NUDIX family hydrolase R General function prediction only ; IPR000086 [NUDIX hydrolase domain] -- -- A6H5Y1 M-phase phosphoprotein 9 Mphosph9 402.4 504.4 137.9 414 521.3 392.3 0.786908707442001 0.462817889990953 -0.345731822509566 Nonsignificant None -- -- M-phase phosphoprotein 9 -- -- -- -- -- -- -- -- Q9R118 Serine protease HTRA1 Htra1 53.6 57.8 81.6 75.5 76.9 74.2 0.851721094439541 0.327349560367723 -0.231547013665073 Nonsignificant None 4 Biological Process:regulation of cell growth (GO:0001558),Molecular Function:protein binding (GO:0005515),Molecular Function:insulin-like growth factor binding (GO:0005520),Cellular Component:extracellular region (GO:0005576) HtrA serine peptidase 1 3.4.21.- -- Serine protease O Posttranslational modification, protein turnover, chaperones ; IPR000867 [Insulin-like growth factor-binding protein, IGFBP] ; IPR001478[PDZ domain] ; IPR002350[Kazal domain] -- -- Q8C9E7 Uncharacterized protein Gm9888 60.3 65.2 63.7 74.7 66.6 63 0.926089084679393 0.250764805059522 -0.110777115393832 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q8BG15 CTD small phosphatase-like protein 2 Ctdspl2 27.3 15.7 23.6 26.1 26.7 25.2 0.853846153846154 0.382299477634958 -0.227951946678349 Nonsignificant None -- -- CTD small phosphatase-like protein 2 3.1.3.- -- TFIIF-interacting CTD phosphatase, including NLI-interacting factor (involved in RNA polymerase II regulation) K Transcription ; IPR004274 [FCP1 homology domain] -- -- Q5IXF8 Glucagon-like peptide 2 receptor Glp2r 88.9 95.6 41.8 68.8 95.5 74.4 0.948051948051948 0.83656068168832 -0.076961981814884 Nonsignificant None 4 Molecular Function:G-protein coupled receptor activity (GO:0004930),Biological Process:G-protein coupled receptor signaling pathway (GO:0007186),Cellular Component:membrane (GO:0016020),Cellular Component:integral component of membrane (GO:0016021) glucagon-like peptide 2 receptor -- ko04080 Neuroactive ligand-receptor interaction Adenylate cyclase-coupled calcitonin receptor T Signal transduction mechanisms ; IPR000832 [GPCR, family 2, secretin-like] ; IPR001879[GPCR, family 2, extracellular hormone receptor domain] -- -- Q6H1V1 Bestrophin-3 Best3 109.8 99.2 84.3 74.7 71 64.8 1.39334916864608 0.0254418289968825 0.478556837803197 Nonsignificant None -- -- bestrophin-3 -- -- Bestrophin (Best vitelliform macular dystrophy-associated protein) R General function prediction only ; IPR021134 [Bestrophin/UPF0187] -- -- Q3UW54 Transposase_22 domain-containing protein 63.8 98.2 179.4 177.3 184.9 98.2 0.741529105125977 0.419043183002936 -0.431424775104492 Nonsignificant None -- -- -- -- -- -- -- -- IPR004244 [Transposase, L1] -- -- Q8BW94 Dynein axonemal heavy chain 3 Dnah3 26.8 37.4 21.7 30.9 44.5 33.1 0.791705069124424 0.29494494612261 -0.336965006193378 Nonsignificant None 3 Molecular Function:microtubule motor activity (GO:0003777),Biological Process:microtubule-based movement (GO:0007018),Cellular Component:dynein complex (GO:0030286) dynein heavy chain, axonemal -- ko05016 Huntington's disease Dyneins, heavy chain Z Cytoskeleton ; IPR004273 [Dynein heavy chain domain] ; IPR013602[Dynein heavy chain, domain-2] ; IPR024317[Dynein heavy chain, P-loop containing D4 domain] ; IPR024743[Dynein heavy chain, coiled coil stalk] -- -- A2ASR8 Polycomb complex protein BMI-1 (Fragment) Bmi1 84.9 86.2 103 98.9 91.6 77.8 1.02161759224748 0.831224451408406 0.030855273565254 Nonsignificant None -- -- polycomb group RING finger protein 4 -- ko04550 Signaling pathways regulating pluripotency of stem cells ko05202 Transcriptional misregulation in cancer ko05206 MicroRNAs in cancer Locus-specific chromosome binding proteins S Function unknown ; IPR032443 [RAWUL domain] -- -- A0A3B2WAS6 Kinetochore protein NDC80 Ndc80 268.5 346.9 184.9 276.4 381.4 220.7 0.910984632896984 0.714607818312231 -0.13450137700746 Nonsignificant None -- -- kinetochore protein NDC80 -- -- Centromere-associated protein HEC1 D Cell cycle control, cell division, chromosome partitioning ; IPR005550 [Kinetochore protein Ndc80] -- -- F6TAL7 Rho guanine nucleotide exchange factor (GEF) 26 (Fragment) Arhgef26 177.3 155 145.3 131.5 153.1 154 1.08891928864569 0.339349379737301 0.122897024591212 Nonsignificant None 2 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Biological Process:regulation of Rho protein signal transduction (GO:0035023) Rho guanine nucleotide exchange factor 26 -- ko05100 Bacterial invasion of epithelial cells Putative guanine nucleotide exchange factor TIM T Signal transduction mechanisms ; IPR000219 [Dbl homology (DH) domain] ; IPR001849[Pleckstrin homology domain] -- -- Q80ZD9 Amphoterin-induced protein 2 Amigo2 150.4 171.3 131.6 150.2 133.8 135.4 1.08082975679542 0.420451222158573 0.112139299789393 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- IPR001611 [Leucine-rich repeat] ; IPR013151[Immunoglobulin] -- -- B1B1A0 Lethal(3)malignant brain tumor-like protein 4 L3mbtl4 29.1 30.1 31.6 26 38.6 32.2 0.93801652892562 0.618369293000108 -0.0923147499836794 Nonsignificant None 3 Molecular Function:protein binding (GO:0005515),Cellular Component:nucleus (GO:0005634),Molecular Function:zinc ion binding (GO:0008270) -- -- -- Polycomb group protein SCM/L(3)MBT (tumor-supressor in Drosophila and humans) K Transcription ; IPR001660 [Sterile alpha motif domain] ; IPR002515[Zinc finger, C2HC-type] ; IPR004092[Mbt repeat] -- zf-C2HC A0A286YD39 Regulator of microtubule dynamics protein 2 (Fragment) Rmdn2 234.7 220.2 229.1 217.8 251.5 237.4 0.967878873638036 0.516427369478042 -0.0471015838914383 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- A2AKF0 N-terminal EF-hand calcium-binding protein 3 (Fragment) Necab3 34.1 26.6 22.8 21.2 17.5 24.5 1.32120253164557 0.15668438445337 0.401851639184312 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- A0A494BA65 Guanine nucleotide-binding protein G(olf) subunit alpha Gnal 47.6 28.4 30.8 101 91.3 164 0.299747403873141 0.0242835188497676 -1.73818083644575 Significant down -- -- -- -- -- -- -- -- -- -- -- O09126 Semaphorin-4D Sema4d 29.6 32.3 26.4 31.7 27.8 29.2 0.995490417136415 0.951299394820717 -0.00652066665259778 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Cellular Component:membrane (GO:0016020) semaphorin 4 -- ko04360 Axon guidance Semaphorins T Signal transduction mechanisms ; IPR001627 [Sema domain] ; IPR002165[Plexin repeat] ; IPR013151[Immunoglobulin] -- -- A0A3B2W3I1 Vomeronasal 2, receptor 3 Vmn2r3 108.5 93.6 84.3 98.3 87.4 115.7 0.950232249502323 0.668690045958326 -0.0736479243335675 Nonsignificant None -- -- -- -- -- Glutamate-gated metabotropic ion channel receptor subunit GRM2 and related subunits, G-protein coupled receptor superfamily PT Inorganic ion transport and metabolism ; Signal transduction mechanisms ; IPR001828 [Receptor, ligand binding region] -- -- A0A494B905 Collagen and calcium-binding EGF domain-containing protein 1 Ccbe1 116 90 103.6 79.8 81 87.2 1.24838709677419 0.0590759558277958 0.320065350870173 Nonsignificant None -- -- collagen and calcium-binding EGF domain-containing protein 1 -- -- Proteins containing Ca2+-binding EGF-like domains T Signal transduction mechanisms ; -- -- -- B7ZP57 Core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (Human) Cbfa2t3 46.6 59.5 39 37.4 37.7 36.1 1.30485611510791 0.198829645890018 0.383890731343237 Nonsignificant None -- -- -- -- -- -- -- -- IPR002893 [Zinc finger, MYND-type] ; IPR003894[TAFH/NHR1] ; IPR014896[NHR2-like] -- -- E9PUQ9 Piezo-type mechanosensitive ion channel component Piezo1 16.8 20.7 16.8 28.7 27.2 16.4 0.75103734439834 0.215959158774076 -0.413043449146756 Nonsignificant None -- -- piezo-type mechanosensitive ion channel component 1/2 -- -- Uncharacterized conserved protein S Function unknown ; IPR031334 [Piezo non-specific cation channel, R-Ras-binding domain] ; IPR031805[Piezo domain] -- -- Q3TXP5 BZIP domain-containing protein Atf6b 20 18.1 19 22.6 29.8 32.3 0.674144037780401 0.0359003529390018 -0.568871223969356 Nonsignificant None 1 Molecular Function:sequence-specific DNA binding (GO:0043565) cyclic AMP-dependent transcription factor ATF-6 beta -- ko04022 cGMP-PKG signaling pathway ko04141 Protein processing in endoplasmic reticulum ko04151 PI3K-Akt signaling pathway ko04211 Longevity regulating pathway ko04261 Adrenergic signaling in cardiomyocytes ko04668 TNF signaling pathway ko04728 Dopaminergic synapse ko04911 Insulin secretion ko04915 Estrogen signaling pathway ko04918 Thyroid hormone synthesis ko04925 Aldosterone synthesis and secretion ko04926 Relaxin signaling pathway ko05030 Cocaine addiction ko05031 Amphetamine addiction ko05034 Alcoholism ko05161 Hepatitis B ko05203 Viral carcinogenesis bZIP transcription factor ATF6 K Transcription ; IPR004827 [Basic-leucine zipper domain] -- TF_bZIP Q8CGY7 Scavenger receptor cysteine-rich type 1 protein CD163c-alpha Scart1 11.2 10.3 14.8 8.7 9 8.8 1.36981132075472 0.140118541726877 0.453977188545189 Nonsignificant None 2 Molecular Function:scavenger receptor activity (GO:0005044),Cellular Component:membrane (GO:0016020) -- -- -- -- -- -- IPR001190 [SRCR domain] -- -- Q3UV99 Uncharacterized protein Vps37a 236.3 221.8 163.5 184.8 188.8 184.5 1.11377889267156 0.441886823682597 0.155462857357364 Nonsignificant None -- -- ESCRT-I complex subunit VPS37 -- ko04144 Endocytosis Uncharacterized conserved protein S Function unknown ; IPR009851 [Modifier of rudimentary, Modr] -- -- D3YVY9 Sister chromatid cohesion protein DCC1 Dscc1 61.4 54.5 60.2 60.6 62.9 52.3 1.00170648464164 0.980568578864391 0.00245983868780419 Nonsignificant None -- -- sister chromatid cohesion protein DCC1 -- -- Uncharacterized conserved protein D Cell cycle control, cell division, chromosome partitioning ; IPR019128 [Sister chromatid cohesion protein Dcc1] -- -- Q3UHN9 Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 Ndst1 22.4 22.6 24.7 34.6 33.1 29.2 0.719298245614035 0.00686763632061155 -0.475338009546658 Nonsignificant None 3 Molecular Function:sulfotransferase activity (GO:0008146),Molecular Function:[heparan sulfate]-glucosamine N-sulfotransferase activity (GO:0015016),Molecular Function:hydrolase activity (GO:0016787) -- -- ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin ko01100 Metabolic pathways Heparan sulfate N-deacetylase/N-sulfotransferase O Posttranslational modification, protein turnover, chaperones ; IPR000863 [Sulfotransferase domain] ; IPR021930[Heparan sulphate-N-deacetylase] -- -- Q922H9 Zinc finger protein 330 Znf330 208.2 198.6 158.5 163.2 161.7 173.7 1.13377456879262 0.229240752026623 0.181133814163916 Nonsignificant None 2 Cellular Component:nucleus (GO:0005634),Molecular Function:zinc ion binding (GO:0008270) -- -- -- -- -- -- IPR010531 [Zinc finger protein NOA36] -- -- Q08AU7 Myeloid-associated differentiation marker-like protein 2 Myadml2 80.8 73.2 82.4 67.6 59.4 65.2 1.22996878251821 0.0169487108485538 0.298621699403782 Nonsignificant None 1 Cellular Component:membrane (GO:0016020) -- -- -- Members of chemokine-like factor super family and related proteins V Defense mechanisms ; IPR008253 [Marvel domain] -- -- Q2TJI5 Protocadherin 7 isoform 3 (Fragment) Pcdh7 212.9 237.3 220.9 218.6 233.5 204.5 1.02208346024977 0.683884081403515 0.0315130072072946 Nonsignificant None -- -- protocadherin delta 1 -- -- -- -- -- IPR013585 [Protocadherin] -- -- D3YWA2 Kinase Ipmk 10.6 13.1 17.6 22.2 16 16.2 0.759191176470588 0.20488835614662 -0.397464869830894 Nonsignificant None 1 Molecular Function:inositol-1,4,5-trisphosphate 3-kinase activity (GO:0008440) -- -- ko00562 Inositol phosphate metabolism ko01100 Metabolic pathways ko04070 Phosphatidylinositol signaling system Inositol polyphosphate multikinase, component of the ARGR transcription regulatory complex KIT Transcription ; Lipid transport and metabolism ; Signal transduction mechanisms ; IPR005522 [Inositol polyphosphate kinase] -- -- Q3UTQ8 Cyclin-dependent kinase-like 5 Cdkl5 104.7 112.2 113.5 100.7 105.8 110.5 1.04227129337539 0.320342971780514 0.0597308463926758 Nonsignificant None 3 Molecular Function:protein kinase activity (GO:0004672),Molecular Function:ATP binding (GO:0005524),Biological Process:protein phosphorylation (GO:0006468) cyclin-dependent kinase-like 2.7.11.22 -- Predicted protein kinase KKIAMRE R General function prediction only ; IPR000719 [Protein kinase domain] -- -- Q8CGF6 WD repeat-containing protein 47 Wdr47 237.9 236.9 198.1 161.8 179.6 173 1.30812597200622 0.019977766890682 0.387501478479481 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) -- -- -- WD40 repeat protein R General function prediction only ; IPR001680 [WD40 repeat] ; IPR024977[Anaphase-promoting complex subunit 4, WD40 domain] -- -- O88413 Tubby-related protein 3 Tulp3 48.4 48.4 37.9 40.3 53.9 45.1 0.966977745872218 0.786786303020504 -0.0484454071389497 Nonsignificant None -- -- -- -- -- Tub family proteins R General function prediction only ; IPR000007 [Tubby, C-terminal] ; IPR005398[Tubby, N-terminal] -- Tub A0A0B4J1I2 Immunoglobulin kappa variable 4-92 (Fragment) Igkv4-92 151.7 140.1 179.7 140.2 177 135.8 1.04083885209713 0.743334758307002 0.0577467206288613 Nonsignificant None -- -- pre-B lymphocyte gene -- -- -- -- -- IPR013106 [Immunoglobulin V-set domain] -- -- Q9D506 Predicted gene 3404 Gm3404 213.4 237 226.1 258.7 264.6 215.3 0.915922014622258 0.289632314513 -0.126703328341714 Nonsignificant None -- -- -- -- -- Guanine-nucleotide releasing factor T Signal transduction mechanisms ; IPR000651 [Ras-like guanine nucleotide exchange factor, N-terminal] -- -- Q3UJ81 Nuclear envelope phosphatase-regulatory subunit 1 Cnep1r1 92.6 90 88.7 72.5 65.9 74.9 1.27191748710736 0.00271511678821475 0.347005081941294 Nonsignificant None 2 Biological Process:positive regulation of protein dephosphorylation (GO:0035307),Cellular Component:Nem1-Spo7 phosphatase complex (GO:0071595) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019168 [Nuclear envelope phosphatase-regulatory subunit 1] -- -- Q8CGI1 Protein FAM193A Fam193a 22.8 38.7 22.5 31.1 22.1 28.6 1.02689486552567 0.908395255472614 0.0382884847243736 Nonsignificant None -- -- -- -- -- -- -- -- IPR031802 [FAM193, C-terminal] -- -- A2ARJ3 Transmembrane protein 236 Tmem236 194.4 169.9 164.3 214.5 244.7 231.5 0.765310554509918 0.0131841582655851 -0.385882798670067 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q7TQS8 Olfactory receptor Olfr1396 51.2 42.5 34.6 33.6 35.7 44 1.1323918799647 0.433604295167837 0.179373309269167 Nonsignificant None -- -- olfactory receptor -- ko04740 Olfactory transduction -- -- -- -- -- -- P62818 Protein S100-A3 S100a3 41.4 41.1 49.5 51.5 50.2 45.5 0.896739130434783 0.199512067888274 -0.157239741811197 Nonsignificant None -- -- -- -- -- -- -- -- IPR013787 [S100/CaBP-9k-type, calcium binding, subdomain] -- -- Q6NVH0 Golgi apparatus membrane protein TVP23 homolog Tvp23a 157.3 138 128.6 133.7 142.8 160.8 0.969357420535102 0.719993709429905 -0.0448993820261121 Nonsignificant None 1 Cellular Component:integral component of membrane (GO:0016021) -- -- -- Uncharacterized membrane protein NPD008/CGI-148 R General function prediction only ; IPR008564 [Protein of unknown function DUF846, eukaryotic] -- -- P43680 Transcription factor SOX-18 Sox18 93.7 111.8 44.2 153.3 151.6 110 0.601831766690769 0.089409262034507 -0.732567835943438 Nonsignificant None -- -- transcription factor SOX7/8/10/18 (SOX group E/F) -- -- HMG-box transcription factor K Transcription ; IPR009071 [High mobility group box domain] ; IPR033392[Sox 7/17/18, central domain] -- HMG Q0VF76 Tetratricopeptide repeat domain 39D Ttc39d 28.2 25.4 33.5 29.1 32 27.5 0.983069977426636 0.862885485007628 -0.0246339799561538 Nonsignificant None -- -- -- -- -- Uncharacterized conserved protein S Function unknown ; IPR019412 [Outer membrane protein Iml2/Tetratricopeptide repeat protein 39] -- -- Q8VDU1 Rho-related GTP-binding protein RhoV Rhov 28.2 30.5 31 43.6 35.7 34 0.791703442188879 0.0630723590963854 -0.336967970901254 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras homolog gene family, member V -- -- Ras-related small GTPase, Rho type R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- Q80XQ2 TBC1 domain family member 5 Tbc1d5 48 44.5 61.3 64.9 57.6 67.9 0.807773109243697 0.11014145033815 -0.307977975346117 Nonsignificant None -- -- TBC1 domain family member 5 -- -- Ypt/Rab-specific GTPase-activating protein GYP6 U Intracellular trafficking, secretion, and vesicular transport ; IPR000195 [Rab-GTPase-TBC domain] -- -- A0A3Q4EI60 Forkhead box protein P3 (Fragment) Foxp3 181.8 224.8 114.6 221.2 292.2 175.7 0.756348860832971 0.296559288474926 -0.402876273530945 Nonsignificant None -- -- forkhead box P3 -- ko04659 Th17 cell differentiation ko05321 Inflammatory bowel disease (IBD) Predicted forkhead transcription factor K Transcription ; -- -- -- B2RXP7 Nat12 protein Naa30 102.4 102.6 128 83.2 105.6 108.5 1.12008072653885 0.365471908250546 0.16360271405098 Nonsignificant None 1 Molecular Function:N-acetyltransferase activity (GO:0008080) N-alpha-acetyltransferase 30 2.3.1.256 -- N-acetyltransferase R General function prediction only ; IPR000182 [GNAT domain] -- -- Q99LB0 Deoxynucleotidyltransferase terminal-interacting protein 1 Dnttip1 41.6 35.3 37.9 48.4 63.7 52 0.699573430834857 0.029696055050909 -0.515452596838025 Nonsignificant None -- -- deoxynucleotidyltransferase terminal-interacting protein 1 -- -- Member of the steroid/thyroid receptor superfamily T Signal transduction mechanisms ; -- -- -- E9QM92 Hyaluronan-binding protein 2 Habp2 97.9 87.9 69.8 149.6 88.3 93.2 0.771972213832679 0.303183218593007 -0.373379174450005 Nonsignificant None 3 Molecular Function:serine-type endopeptidase activity (GO:0004252),Molecular Function:protein binding (GO:0005515),Biological Process:proteolysis (GO:0006508) hyaluronan binding protein 2 3.4.21.- -- Fibrillins and related proteins containing Ca2+-binding EGF-like domains T Signal transduction mechanisms ; IPR000001 [Kringle] ; IPR000742[EGF-like domain] ; IPR001254[Serine proteases, trypsin domain] -- -- D3Z7Q3 Guanine nucleotide-binding protein subunit gamma Gng5 137.9 124.9 120.3 137.2 141.5 133 0.930531940733544 0.17636567384202 -0.103872422897389 Nonsignificant None 3 Molecular Function:signal transducer activity (GO:0004871),Cellular Component:heterotrimeric G-protein complex (GO:0005834),Biological Process:G-protein coupled receptor signaling pathway (GO:0007186) guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 -- ko04014 Ras signaling pathway ko04062 Chemokine signaling pathway ko04151 PI3K-Akt signaling pathway ko04371 Apelin signaling pathway ko04713 Circadian entrainment ko04723 Retrograde endocannabinoid signaling ko04724 Glutamatergic synapse ko04725 Cholinergic synapse ko04726 Serotonergic synapse ko04727 GABAergic synapse ko04728 Dopaminergic synapse ko04926 Relaxin signaling pathway ko05032 Morphine addiction ko05034 Alcoholism ko05167 Kaposi's sarcoma-associated herpesvirus infection ko05200 Pathways in cancer G protein gamma subunit T Signal transduction mechanisms ; IPR015898 [G-protein gamma-like domain] -- -- A0A1W2P6H1 Non-specific serine/threonine protein kinase Obscn 131.8 171.3 79.4 172.6 187.9 112.8 0.808155503908726 0.437396547987302 -0.307295174270987 Nonsignificant None 3 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Molecular Function:protein binding (GO:0005515),Biological Process:regulation of Rho protein signal transduction (GO:0035023) obscurin-RhoGEF 2.7.11.1 -- -- -- -- IPR000048 [IQ motif, EF-hand binding site] ; IPR000219[Dbl homology (DH) domain] ; IPR003961[Fibronectin type III] ; IPR013098[Immunoglobulin I-set] -- -- D6RI62 Putative Polycomb group protein ASXL2 (Fragment) Asxl2 39.9 43.3 57.1 43.3 43.6 48.6 1.03542435424354 0.78681037940949 0.0502221573786652 Nonsignificant None -- -- additional sex combs-like protein -- -- -- -- -- IPR007759 [HB1/Asxl, restriction endonuclease HTH domain] ; IPR028020[ASX homology domain] -- -- Q3UPG3 Uncharacterized protein Gpsm2 12.1 10.2 11.8 11.4 11.2 10.4 1.03333333333333 0.610290995412077 0.0473057147783568 Nonsignificant None 2 Molecular Function:protein binding (GO:0005515),Molecular Function:GTPase regulator activity (GO:0030695) G-protein signaling modulator 2 -- -- Predicted G-alpha GTPase interaction protein, contains GoLoco domain T Signal transduction mechanisms ; IPR003109 [GoLoco motif] ; IPR019734[Tetratricopeptide repeat] -- -- A2RSH1 Phosphodiesterase Pde4d 31.6 38.8 37.1 43.6 53.9 44.9 0.754915730337079 0.0406175618489526 -0.405612486489575 Nonsignificant None 2 Molecular Function:3',5'-cyclic-nucleotide phosphodiesterase activity (GO:0004114),Biological Process:signal transduction (GO:0007165) cAMP-specific phosphodiesterase 4 3.1.4.53 ko00230 Purine metabolism ko04024 cAMP signaling pathway ko05032 Morphine addiction Cyclic nucleotide phosphodiesterase T Signal transduction mechanisms ; IPR002073 [3'5'-cyclic nucleotide phosphodiesterase, catalytic domain] -- -- Q9Z0M3 Cadherin-20 Cdh20 143.8 189.7 62.9 124.2 172.4 110.2 0.974434611602753 0.937558129559356 -0.037362716671012 Nonsignificant None 3 Molecular Function:calcium ion binding (GO:0005509),Biological Process:homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156),Cellular Component:membrane (GO:0016020) cadherin 20, type 2 -- -- FOG: Cadherin repeats S Function unknown ; IPR000233 [Cadherin, cytoplasmic domain] ; IPR002126[Cadherin] -- -- Q05421 Cytochrome P450 2E1 Cyp2e1 51.4 174.9 169 190.7 197.6 136.9 0.752665651180503 0.386229087489176 -0.409918961073273 Nonsignificant None 3 Molecular Function:iron ion binding (GO:0005506),Molecular Function:heme binding (GO:0020037),Biological Process:oxidation-reduction process (GO:0055114) cytochrome P450 family 2 subfamily E polypeptide 1 1.14.13.- ko00140 Steroid hormone biosynthesis ko00590 Arachidonic acid metabolism ko00591 Linoleic acid metabolism ko00980 Metabolism of xenobiotics by cytochrome P450 ko00982 Drug metabolism - cytochrome P450 ko01100 Metabolic pathways ko04932 Non-alcoholic fatty liver disease (NAFLD) ko05204 Chemical carcinogenesis Cytochrome P450 CYP2 subfamily Q Secondary metabolites biosynthesis, transport and catabolism ; IPR001128 [Cytochrome P450] -- -- O08601 Microsomal triglyceride transfer protein large subunit Mttp 9 7.4 6 7.5 7.2 7.3 1.01818181818182 0.892148487760834 0.0259952085329447 Nonsignificant None 2 Molecular Function:lipid transporter activity (GO:0005319),Biological Process:lipid transport (GO:0006869) microsomal triglyceride transfer protein large subunit -- ko04975 Fat digestion and absorption Microsomal triglyceride transfer protein IU Lipid transport and metabolism ; Intracellular trafficking, secretion, and vesicular transport ; IPR001747 [Lipid transport protein, N-terminal] -- -- Q3UPS8 Uncharacterized protein (Fragment) Pdzrn3 104.7 127.2 125.3 122.5 121.6 119.9 0.981318681318681 0.783406836998022 -0.0272063699648358 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) ligand of Numb protein X 3/4 2.3.2.27 -- Uncharacterized conserved protein S Function unknown ; IPR001478 [PDZ domain] -- -- Q9CPW5 Translocon-associated protein subunit beta Ssr2 598.7 560.2 584.1 527.1 528.8 499.8 1.12039596323199 0.0129939753237944 0.164008690528193 Nonsignificant None -- -- translocon-associated protein subunit beta -- ko04141 Protein processing in endoplasmic reticulum Translocon-associated complex TRAP, beta subunit U Intracellular trafficking, secretion, and vesicular transport ; -- -- -- P97347 Repetin Rptn 107.2 118.8 87.9 91.2 87.6 101.3 1.12067118886112 0.318680224034744 0.164363045507609 Nonsignificant None -- -- -- -- -- -- -- -- IPR013787 [S100/CaBP-9k-type, calcium binding, subdomain] -- -- A0A0R5RP28 Sodium channel protein Scn2a 58.2 76.7 83.3 87.7 85.4 68.1 0.904643449419569 0.474854268824634 -0.144578805576478 Nonsignificant None 7 Cellular Component:voltage-gated sodium channel complex (GO:0001518),Molecular Function:ion channel activity (GO:0005216),Molecular Function:voltage-gated sodium channel activity (GO:0005248),Biological Process:ion transport (GO:0006811),Biological Process:sodium ion transport (GO:0006814),Cellular Component:membrane (GO:0016020),Biological Process:transmembrane transport (GO:0055085) voltage-gated sodium channel type II alpha -- ko04742 Taste transduction Voltage-gated Ca2+ channels, alpha1 subunits PT Inorganic ion transport and metabolism ; Signal transduction mechanisms ; IPR005821 [Ion transport domain] ; IPR010526[Sodium ion transport-associated] ; IPR024583[Voltage-gated Na+ ion channel, cytoplasmic domain] -- -- B2RX77 DNA-directed RNA polymerase III subunit RPC3 Polr3c 180.4 180.8 193.4 181.8 188.6 191.4 0.987184051263795 0.664401484469746 -0.0186090080869197 Nonsignificant None 2 Molecular Function:DNA binding (GO:0003677),Molecular Function:DNA-directed 5'-3' RNA polymerase activity (GO:0003899) DNA-directed RNA polymerase III subunit RPC3 -- ko00230 Purine metabolism ko00240 Pyrimidine metabolism ko01100 Metabolic pathways ko03020 RNA polymerase ko04623 Cytosolic DNA-sensing pathway ko05169 Epstein-Barr virus infection RNA polymerase III (C) subunit K Transcription ; IPR008806 [RNA polymerase III Rpc82, C -terminal] ; IPR013197[RNA polymerase III subunit RPC82-related, helix-turn-helix] -- -- Q9D4Z8 Uncharacterized protein 4930533O14Rik 36.4 45.3 128.6 132.5 118.7 112.1 0.578860445912469 0.164042540205471 -0.788712515683706 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q8R1T7 Aqp9 protein Aqp9 281.8 299.1 349.2 298.4 297 333.6 1.00118406889128 0.988293825527303 0.00170723977211713 Nonsignificant None 3 Molecular Function:transporter activity (GO:0005215),Biological Process:transport (GO:0006810),Cellular Component:membrane (GO:0016020) aquaporin-9 -- ko04976 Bile secretion Aquaporin (major intrinsic protein family) G Carbohydrate transport and metabolism ; IPR000425 [Major intrinsic protein] -- -- B7ZWH2 Hfm1 protein (Fragment) Hfm1 103.9 106 107.2 99.5 124.9 112.7 0.940670424206467 0.459841358672385 -0.0882387498803712 Nonsignificant None 2 Molecular Function:nucleic acid binding (GO:0003676),Molecular Function:ATP binding (GO:0005524) ATP-dependent DNA helicase HFM1/MER3 3.6.4.12 -- DNA/RNA helicase MER3/SLH1, DEAD-box superfamily A RNA processing and modification ; IPR011545 [DEAD/DEAH box helicase domain] -- -- F2Z432 GTP-binding protein Rit2 Rit2 64.7 57.1 52.8 64.3 78.4 73.2 0.808707735062529 0.0630270860585014 -0.306309684393065 Nonsignificant None 2 Molecular Function:GTP binding (GO:0005525),Biological Process:small GTPase mediated signal transduction (GO:0007264) Ras-like without CAAX 2 -- -- Ras-related GTPase R General function prediction only ; IPR001806 [Small GTPase superfamily] -- -- A2AG50 MAP7 domain-containing protein 2 Map7d2 39.5 75.1 39.8 71.8 103.8 67.2 0.635914332784184 0.14859530383471 -0.653095668987602 Nonsignificant None 2 Biological Process:microtubule cytoskeleton organization (GO:0000226),Cellular Component:microtubule cytoskeleton (GO:0015630) -- -- -- -- -- -- IPR008604 [Microtubule-associated protein 7 family] -- -- Q9DBB9 Carboxypeptidase N subunit 2 Cpn2 288.2 280.7 319.3 254.4 274 249.5 1.14179200411364 0.0582785530809714 0.191299864392662 Nonsignificant None 1 Molecular Function:protein binding (GO:0005515) carboxypeptidase N regulatory subunit -- -- FOG: Leucine rich repeat R General function prediction only ; IPR001611 [Leucine-rich repeat] -- -- Q3T9Q0 Rab-GAP TBC domain-containing protein (Fragment) Tbc1d20 7.1 5.8 0 6.3 7 7.3 0.939320388349514 0.548032036305248 -0.0903107710388082 Nonsignificant None -- -- TBC1 domain family member 20 -- -- Predicted GTPase activator protein T Signal transduction mechanisms ; IPR000195 [Rab-GTPase-TBC domain] -- -- Q3TR66 Vitamin K-dependent protein S Pros1 52.9 54.5 37.1 27.1 30.9 37 1.52105263157895 0.057749401953511 0.605070074169731 Nonsignificant None 3 Molecular Function:calcium ion binding (GO:0005509),Molecular Function:protein binding (GO:0005515),Cellular Component:extracellular region (GO:0005576) protein S -- ko04610 Complement and coagulation cascades -- -- -- IPR000294 [Gamma-carboxyglutamic acid-rich (GLA) domain] ; IPR000742[EGF-like domain] ; IPR001791[Laminin G domain] ; IPR001881[EGF-like calcium-binding domain] -- -- Q8BH05 Zinc finger protein 750 Znf750 47.4 62.3 36.5 49.7 79.1 51 0.813125695216908 0.409189086305342 -0.29844970956201 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q925H9 Keratin-associated protein 16.2 (Fragment) Krtap19-1 49.1 36.7 38.7 41.1 34.8 43.2 1.04534005037783 0.715416899146731 0.0639723290913291 Nonsignificant None -- -- -- -- -- -- -- -- IPR021743 [Keratin-associated protein, type6/8/16/19/20/21] -- -- B2RWX5 Centrosomal protein 250 Cep250 82.4 81.3 87.6 129.9 111.7 130 0.676264800861141 0.0032842360655227 -0.564339830501998 Nonsignificant None -- -- centrosomal protein CEP250 -- -- -- -- -- -- -- -- E0CXQ5 UNC5C-like protein Unc5cl 228 265.1 67.3 366.1 424.5 193.4 0.569512195121951 0.200359500287141 -0.812201359795784 Nonsignificant None -- -- -- -- -- Netrin transmembrane receptor unc-5 T Signal transduction mechanisms ; -- -- -- P42867 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase Dpagt1 70.2 71.4 92.6 78.2 94.6 78.2 0.933067729083665 0.571585982941737 -0.0999462883369195 Nonsignificant None 2 Molecular Function:phospho-N-acetylmuramoyl-pentapeptide-transferase activity (GO:0008963),Cellular Component:integral component of membrane (GO:0016021) UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 2.7.8.15 ko00510 N-Glycan biosynthesis ko01100 Metabolic pathways Glycosyltransferase G Carbohydrate transport and metabolism ; IPR000715 [Glycosyl transferase, family 4] -- -- D6RHR5 WD repeat-containing protein 44 Wdr44 17 14.8 16.5 19.9 22.1 21.1 0.765451664025357 0.0058543164946412 -0.385616816146776 Nonsignificant None -- -- WD repeat-containing protein 44 -- -- WD40 repeat-containing protein S Function unknown ; -- -- -- Q3U022 Uncharacterized protein 180 182.5 156.9 153.9 143 166.6 1.12060409924488 0.154362584633819 0.164276675165514 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- A0A0A6YXB0 RBR-type E3 ubiquitin transferase Arih2 57.3 52.4 38.5 44.8 37.9 51 1.10845175766642 0.515512565911583 0.148545982212481 Nonsignificant None -- -- ariadne-2 2.3.2.27 -- Predicted E3 ubiquitin ligase O Posttranslational modification, protein turnover, chaperones ; IPR002867 [IBR domain] -- -- A0A1D5RLB2 Ankyrin-2 (Fragment) Ank2 199 180.9 234.9 247.7 212 230.8 0.890369297610427 0.253262176663672 -0.167524249454642 Nonsignificant None -- -- ankyrin -- ko05205 Proteoglycans in cancer Ankyrin M Cell wall/membrane/envelope biogenesis ; IPR000906 [ZU5 domain] -- -- Q8C4G0 Uncharacterized protein Eml5 331.1 338.4 406.6 451.2 440.7 415.8 0.822895159440239 0.0422743263942462 -0.281219458396473 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q3TNG2 Uncharacterized protein Nsmf 4.7 7.7 12.9 7.1 12.7 10.3 0.840531561461794 0.609664836829182 -0.250626102065392 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q3TMA0 MFS domain-containing protein Slc16a3 185 206 153 114 126.4 117.7 1.51912873499023 0.0173692701189915 0.603244132817177 Significant up 2 Cellular Component:integral component of membrane (GO:0016021),Biological Process:transmembrane transport (GO:0055085) MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 3 -- ko05230 Central carbon metabolism in cancer Monocarboxylate transporter G Carbohydrate transport and metabolism ; IPR011701 [Major facilitator superfamily] -- -- A2AJL4 FGGY carbohydrate kinase domain-containing protein Fggy 33.8 27.4 21.4 26.3 38.8 32.6 0.845445240532242 0.378133093516095 -0.24221678054894 Nonsignificant None 1 Biological Process:carbohydrate metabolic process (GO:0005975) -- -- -- Ribulose kinase and related carbohydrate kinases G Carbohydrate transport and metabolism ; IPR018484 [Carbohydrate kinase, FGGY, N-terminal] ; IPR018485[Carbohydrate kinase, FGGY, C-terminal] -- -- Q9JI38 tRNA pseudouridine(38/39) synthase Pus3 23.8 23.4 27.2 19.7 39.4 30.9 0.826666666666667 0.42288156147511 -0.274622380109006 Nonsignificant None 4 Biological Process:pseudouridine synthesis (GO:0001522),Molecular Function:RNA binding (GO:0003723),Biological Process:RNA modification (GO:0009451),Molecular Function:pseudouridine synthase activity (GO:0009982) tRNA pseudouridine38/39 synthase 5.4.99.45 -- Pseudouridylate synthase J Translation, ribosomal structure and biogenesis ; IPR020097 [Pseudouridine synthase I, TruA, alpha/beta domain] -- -- E9PXF0 Protocadherin 17 Pcdh17 66 68.2 84.3 78.8 88.3 73.6 0.907769007062734 0.36195627011484 -0.139602862086536 Nonsignificant None 3 Molecular Function:calcium ion binding (GO:0005509),Biological Process:homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156),Cellular Component:membrane (GO:0016020) protocadherin delta 2 -- -- FOG: Cadherin repeats S Function unknown ; IPR002126 [Cadherin] ; IPR013164[Cadherin, N-terminal] -- -- S4R189 Rho guanine nucleotide exchange factor 40 Arhgef40 69.5 90.6 63.2 107.3 80.4 98.1 0.781315605318404 0.142789878825944 -0.356022665273343 Nonsignificant None 2 Molecular Function:Rho guanyl-nucleotide exchange factor activity (GO:0005089),Biological Process:regulation of Rho protein signal transduction (GO:0035023) -- -- -- Guanine nucleotide exchange factor for Rho and Rac GTPases T Signal transduction mechanisms ; IPR000219 [Dbl homology (DH) domain] -- -- Q8N9S3 Activator of 90 kDa heat shock protein ATPase homolog 2 Ahsa2 75.7 67.6 68.7 55.4 63.3 60.8 1.18105849582173 0.0346957734220887 0.240080420740148 Nonsignificant None 3 Molecular Function:ATPase activator activity (GO:0001671),Biological Process:response to stress (GO:0006950),Molecular Function:chaperone binding (GO:0051087) -- -- -- Uncharacterized conserved protein S Function unknown ; IPR013538 [Activator of Hsp90 ATPase homologue 1-like] ; IPR015310[Activator of Hsp90 ATPase, N-terminal] -- -- A0A1B0GT27 PNMA family member 8C Pnma8c 68 50 67 56.2 70.5 64.3 0.968586387434555 0.793813844532105 -0.0460473675194366 Nonsignificant None -- -- -- -- -- -- -- -- IPR026523 [Paraneoplastic antigen Ma] -- -- E0CYX9 Coiled-coil domain-containing protein 127 (Fragment) Ccdc127 586.4 691.3 308.3 773.6 891.1 609.3 0.697449428320141 0.177921596758288 -0.51983948318827 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- A0A0A6YXY1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 (Fragment) Ntmt1 46.2 37 35.7 34.2 21.5 33.6 1.33146696528555 0.135858078863325 0.413016634624433 Nonsignificant None 2 Biological Process:N-terminal protein amino acid methylation (GO:0006480),Molecular Function:methyltransferase activity (GO:0008168) protein N-terminal methyltransferase 2.1.1.244 -- Hydroxyindole-O-methyltransferase and related SAM-dependent methyltransferases R General function prediction only ; IPR008576 [Alpha-N-methyltransferase NTM1] -- -- B7ZWB7 SH2 domain-containing protein Sh2d1b1 41.2 40.4 46.4 48.2 46.2 39.1 0.958801498127341 0.612357773387143 -0.0606959316875541 Nonsignificant None -- -- EWS/FLI1 activated transcript 2 -- ko04650 Natural killer cell mediated cytotoxicity Inositol polyphosphate 5-phosphatase and related proteins U Intracellular trafficking, secretion, and vesicular transport ; IPR000980 [SH2 domain] -- -- Q8BY68 Purinergic receptor P2Y, G-protein-coupled 10B P2ry10b 105.8 114.9 142.6 135.6 150.9 138.5 0.854823529411765 0.162240612401597 -0.226301475496941 Nonsignificant None 3 Molecular Function:G-protein coupled receptor activity (GO:0004930),Biological Process:G-protein coupled receptor signaling pathway (GO:0007186),Cellular Component:integral component of membrane (GO:0016021) purinergic receptor P2Y, G protein-coupled, 10 -- ko04080 Neuroactive ligand-receptor interaction -- -- -- IPR000276 [G protein-coupled receptor, rhodopsin-like] -- -- Q922Z1 Lipid droplet assembly factor 1 Ldaf1 171.1 160.3 160.7 143.3 151.6 171 1.05623524361451 0.383772937217796 0.0789311860216819 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q9D7I8 Protein FAM83D Fam83d 90.3 103.9 74.2 138.4 137.6 105.8 0.702985856469356 0.0513749565286172 -0.508432431203754 Nonsignificant None -- -- protein FAM83D -- -- -- -- -- IPR012461 [Protein of unknown function DUF1669] -- -- E9PWJ7 ATP-binding cassette, sub-family A (ABC1), member 16 Abca16 31.2 35.5 37.9 40.9 46.4 37.9 0.835463258785943 0.0960699367831395 -0.259351710685677 Nonsignificant None 2 Molecular Function:ATP binding (GO:0005524),Molecular Function:ATPase activity (GO:0016887) -- -- -- Lipid exporter ABCA1 and related proteins, ABC superfamily IR Lipid transport and metabolism ; General function prediction only ; IPR003439 [ABC transporter-like] -- -- Q9D4J3 Discoidin, CUB and LCCL domain-containing protein 1 Dcbld1 79.4 49.1 40.7 33.2 129 47.9 0.805330794859591 0.69219869357905 -0.312346593553096 Nonsignificant None -- -- -- -- -- -- -- -- IPR000859 [CUB domain] ; IPR004043[LCCL domain] -- -- Q8C8Z0 Uncharacterized protein (Fragment) Gm9997 203.3 178.9 127.8 220.8 248.6 181.5 0.783530496235981 0.187272418277699 -0.351938667142675 Nonsignificant None -- -- -- -- -- -- -- -- -- -- -- Q7TPN9 Proline-rich protein 14 Prr14 65 86.5 83.8 86.1 101.6 85.4 0.861589161479312 0.21603181379391 -0.214927993540989 Nonsignificant None -- -- -- -- -- -- -- -- IPR028149 [Tantalus-like] -- -- Q8CGY6 Protein unc-45 homolog B Unc45b 93.1 90.7 235.5 260.5 265 249.5 0.541032258064516 0.130319314136252 -0.886213480202572 Nonsignificant None -- -- protein unc-45 -- -- Myosin assembly protein/sexual cycle protein and related proteins ODR Posttranslational modification, protein turnover, chaperones ; Cell cycle control, cell division, chromosome partitioning ; General function prediction only ; IPR024660 [UNC-45/Cro1/She4, central domain] -- -- Q8R1N0 Zinc finger protein 830 Znf830 164.2 169.2 146.2 156.7 175.2 165.1 0.964989939637827 0.545697425224682 -0.051414193035425 Nonsignificant None -- -- zinc finger protein 830 -- -- Uncharacterized conserved protein S Function unknown ; -- -- --